Patterns, causes, and consequences of marine larval dispersal | PNAS
2002) Age-based studies. Coral Reef Fishes: Dynamics and Diversity in a Complex Ecosystem, ed Sale PF (Academic, San Diego), pp ... 2D). This result should be treated with some caution because size is a coarse proxy for postsettlement age in fishes (see ... 2B). However, there was no evidence for any effect of direction, settler standard length (a proxy for age), or pelagic larval ... Using Size as a Proxy for Age.. To test whether postsettlement processes influenced the shape of the observed kernel, we used ...
Aging and the encoding of changes in events: The role of neural activity pattern reinstatement | PNAS
Differential effects of age on item and associative measures of memory: A meta-analysis. Psychol. Aging 23, 104-118 (2008).. ... Aging and autobiographical memory: Dissociating episodic from semantic retrieval. Psychol. Aging 17, 677-689 (2002).. ... Similar models with age group added as a fixed effect revealed no age differences [PMC, χ2(1) = 0.07, P = 0.79; MTL, χ2(1) = ... Aging and the encoding of changes in events: The role of neural activity pattern reinstatement. David Stawarczyk, View ORCID ...
Edaravone alleviates Alzheimer's disease-type pathologies and cognitive deficits | PNAS
APP/PS1 mice aged 9 mo were treated with Edaravone (12-mo Tg EDA, n = 9) or saline (12-mo Tg Ctrl, n = 7) for 3 mo. (A-C) MAP2 ... S9A), we fed APP/PS1 mice with Edaravone at 33.2 mg/kg/d between the ages of 3 and 12 mo. The Morris water maze test by 12 mo ... By 12 mo of age, although the escaping latency in the treatment group was longer than that in WT mice (Fig. 2H), it was similar ... S3H). In male APP/PS1 mice, Edaravone treatment from 9 to 12 mo of age also improved behavioral performances (Fig. S4 A-C). ...
Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease | PNAS
Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to ...
The role of worldviews in the governance of sustainable mobility | PNAS
The dataset that supports our findings is the BSA 2016 (15). It is designed to yield a representative sample of adults aged 18 ... The survey is designed to produce a representative sample of adults aged 18 or over. As an important barometer of public ... Estimated configuration of worldview adherents in Great Britain (adults aged 18 or over). ...
Disintermediating your friends: How online dating in the United States displaces other ways of meeting | PNAS
Cyberintimacy: A Scoping Review of Technology-Mediated Romance in the Digital Age ...
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity | PNAS
All mouse dietary and high-fat feeding experiments were performed with age matched littermate controls. At age 8 wk, mice were ... Mice were male C57BL/6J (age 12 wk; Jackson Laboratories) and were housed in a temperature-controlled (23 °C) room on a 12-h ...
A genomic and historical synthesis of plague in 18th century Eurasia | PNAS
As 2015 is the age of the most recent isolate, the age of CHE1 is estimated to be between 1613 and 1836 with a mean age of 1729 ... Blekinge, Sweden) (16, 17). The skeleton was identified as a male between the age of 20 and 25 y at the time of death (SI ... The Stone Age plague and its persistence in Eurasia. Curr. Biol. 27, 3683-3691.e8 (2017).. ... Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague. Nat. Commun. 9, 2234 (2018).. ...
Ancient Maya wetland fields revealed under tropical forest canopy from laser scanning and multiproxy evidence | PNAS
... and the AMS laboratories calibrated ages using INTACAL13 and corrected all ages for fractionation. Here we report all ages ... most AMS ages become younger in the aggrading floodplain over the last millennium, whereas below the Ab, most radiocarbon ages ... and The University of Arizonas AMS Lab provided ages for 11 more samples. Conventional ages are in years BP (BP = Before ... AMS ages date to the Late to Terminal Classic within three separate ash layers (1309-1083 BP), sandwiched by three Terminal to ...
A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome | PNAS
Carbohydrates are intricate information-carrying biopolymers of rising interest in the postgenomic age. Dynamic changes in ...
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model | PNAS
The cumulative data revealed that all male mice with the genotype of FoxP3-GFPcreKI/Y PD-1 KO died within 3 mo of age (Fig. 1A ... Littermate or the appropriate age/sex-matched mice were used as control. All mice were housed in a specific pathogen-free ...
Profile of Charles M. Rice | PNAS
Rice developed a fondness for animals at a young age. "I had dogs as brothers and sisters, so I was naturally attached to ...
Climate change and the selective signature of the Late Ordovician mass extinction | PNAS
2008) The Red Queen revisited: reevaluating the age selectivity of Phanerozoic marine genus extinctions. Paleobiology 34:318- ... In addition to these three variables, regressions controlled for genus age, occupancy, substrate preference, and Laurentian and ... we quantified genus age (time since first appearance), global geographic range (great circle distance), Laurentian and global ... genus age, and substrate preference, suggests that thermal tolerance range played an important role in determining extinction ...
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD...
RNA-seq was performed on striatal RNA isolated from a cohort of 12 sheep aged 5 y (six OVT73, six controls) to facilitate ... 1993) Trinucleotide repeat length instability and age of onset in Huntingtons disease. Nat Genet 4:387-392. ... There is an inverse correlation between expanded CAG repeat size and age at onset of symptoms (4⇓-6). Although the mutation is ... tissue was dissected from frozen tissue blocks previously isolated from 30 HD cases and 18 age-matched non-HD controls. Case ...
Carbonaceous meteorites contain a wide range of extraterrestrial nucleobases | PNAS
Resolving the age of the Haughton impact structure using coupled 40Ar/39Ar and U-Pb geochronology ...
Declining greenness in Arctic-boreal lakes | PNAS
Estimating the volume and age of water stored in global lakes using a geo-statistical approach. Nat. Commun. 7, 13603 (2016).. ...
Farming and public goods production in Caenorhabditis elegans populations | PNAS
S5-S6, and Movies S3 and S4). A further simplified version of this model that ignores the age structure of the worm population ... Worms were age-synchronized by bleaching and individual larval stage 4 (L4) worms were placed onto dishes of the appropriate ... Brood size was quantified by counting the number of embryos laid in 24-h intervals by age-synchronized worms on standard NGM ... The worm population is age-structured into four stages: eggs, sexually immature, mature, and infertile worms. Eggs hatch at a ...
Social supports and serotonin transporter gene moderate depression in maltreated children | PNAS
Children ranged in age from 5 to 15 years, with a mean age of 10.0 ± 2.3 years. Twenty-one percent of the children were ... Age, sex, and ancestral proportion scores were entered in all of the models as covariates and were retained in the models ... The ASSIS (34) is an interview that was originally developed for adults and was revised for use with school-aged children (5). ... Predicting Depression Symptoms. In the first GEE analysis, none of the covariates (e.g., age, sex, ancestral proportion scores ...
Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage | PNAS
2012) A mutation in APP protects against Alzheimers disease and age-related cognitive decline. Nature 488(7409):96-99. ... This research was supported by the National Institutes of Health, National Institute of Aging Grant AG047781 (to P.G.), the US ... which was recently discovered in the Icelandic population and has been shown to protect against the development of AD and age- ... that protects against the development of AD and age-related cognitive decline was identified in the Icelandic population (7, 8 ...
Worldwide data sets constrain the water vapor uptake coefficient in cloud formation | PNAS
2011) Size-resolved CCN distributions and activation kinetics of aged continental and marine aerosol. Atmos Chem Phys 11(16): ... We also include two previous studies on the activation kinetics of aged marine air in the eastern Mediterranean (15, 16) and ... fresh and aged biomass burning plumes, and continental air with anthropogenic and biogenic influences. ...
A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength | PNAS
2007) Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res 22:1197-1207. ... recent demonstration that inducible osteoblast-specific Bmpr1a ablation increases bone mass in mice of 3 wk and 22 wk of age ( ...
caspase | PNAS
DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration Younghee Kim, Valeria ...
Modeling the role of voyaging in the coastal spread of the Early Neolithic in the West Mediterranean | PNAS
1B the median of each sites 2σ calibrated age range (given by error bars) arranged in terms of space and time. Because we are ... A) Archaeological sites (circles) are colored according to the median of the calibrated age range of their earliest date. The ... it occurs in small numbers at the sites of this age in southern France (16), and it has yet to be documented in the case of the ...
Reply to Rogeberg and Daly: No evidence that socioeconomic status or personality differences confound the association between...
Third, we compared each participants cognitive scores at age 38 y to their former scores on the same tests taken up to age 13 ... Change in full-scale IQ (in SD units) from childhood to adulthood as a function of the number of study waves between ages 18-38 ... Finally, we attempted to rule out rival causal explanations, i.e., factors occurring after age 13 y that might account for the ... His cannabis-exposure variable does not ascertain the essential features of exposure in our study, young age of onset or ...
Twentieth century surge of excess adult male mortality | PNAS
We show that excess adult male mortality is clearly rooted in specific age groups, 50-70, and that the sex asymmetry emerged in ... We further show that smoking-attributable deaths account for about 30% of excess male mortality at ages 50-70 for cohorts born ... Smoking behavior accounts for about 30% of male excess mortality at ages 50-70 for those born in 1900-1935. The remaining ... However, after accounting for smoking, substantial excess male mortality at ages 50-70 remained, particularly from ...
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1 | PNAS
We used Epac1−/− mice (17, 48) and their WT control littermates in a C57BL/6 background at an age of 12-14 wk. All procedures ... and their WT control littermates in a C57BL/6 background at an age of 12-14 wk. All procedures were in accordance with National ...
Group size in social-ecological systems | PNAS
In Trentino, the most valuable tree (red fir) reaches its maximum productivity between 60 and 90 y of age (35). Our results ...
Bayesian learning of visual chunks by human observers | PNAS
Undergraduates from the University of Rochester or Brandeis University, ranging in age from 18 to 25 years, served as the ...
Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis | PNAS
4B). In our study, among 32 TM-injected CGRPCreER/+;p53f/f;Rbf/f adult mice at 5-6 mo of age, 4 developed PNEC hyperplasias and ... We injected CGRPCreER/+;ROSA26mTmG/+ mice with TM at 1-2 mo of age and analyzed cell types labeled by eGFP at 0, 2, 4, 6, 8, ... K-O) Immunostaining of lung sections from adult CGRPCreER/+;ROSA26mTmG/+ mice injected with tamoxifen at 1 mo of age and ... We injected CGRPCreER/+;ROSA26mTmG/+ mice at 1-2 mo of age with TM to label PNECs, and this was followed by naphthalene ...
Prescriptive scientific narratives for communicating usable science | PNAS
... age, disability status, medical condition, and so forth). Interactivity can provide individuals with the content that is ...