*  p-[125I]iodoclonidine is a partial agonist at the alpha 2-adrenergic receptor.
0/Adrenergic alpha-Agonists; 0/Iodine Radioisotopes; 0/Receptors, Adrenergic, alpha; 108294-53-7/4-iodoclonidine; 146-48-5/ ... Adrenergic alpha-Agonists / pharmacokinetics*. Blood Platelets / metabolism*. Cell Membrane / metabolism. Chromatography, Thin ... 8267204 - Methylprednisolone increases sensitivity to beta-adrenergic agonists within 48 hours in.... 6147954 - Adrenergic ... Thus, PIC behaves as a partial agonist in a human platelet aggregation assay. [125I]PIC binds to the alpha 2B-AR in NG-10815 ...
  http://www.biomedsearch.com/nih/p-125Iiodoclonidine-partial-agonist-at/1974694.html
*  EP 2329849 A1 - Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or...
Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or Preventing An ...
  https://www.lens.org/lens/patent/EP_2329849_A1/family
*  Mivazerol, a new alpha 2-adrenergic agonist, blunts cardiovascular effects following surgical stress in pentobarbital...
... a new alpha 2-adrenergic agonist, blunts cardiovascular effects following surgical stress in pentobarbital-anesthetized rats ... Mivazerol is a new and selective alpha 2-adrenoceptor agonist, devoid of hypotensive effects, which has been designed to ... Mivazerol, a new alpha 2-adrenergic agonist, blunts cardiovascular effects following surgical stress in pentobarbital- ... Pretreatment with the alpha 2-adrenoceptor antagonist rauwolscine (0.5 mg/kg, i.v.) blocked the bradycardia induced by ...
  http://www.curehunter.com/public/pubmed9241327.do
*  Access to Extended Release Guanfacine HCl for Subjects Who Participated in Studies SPD503-315 or SPD503-316 in Europe - Full...
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Subjects will be dosed orally once-daily in the AM at 1, 2, 3, 4, 5, 6, or 7 mg according to subjects weight and age ... This is an extension study that will allow participants access to Extended-release Guanfacine Hydrochloride (HCl) for up to 2 ... Final Assessment is the last valid assessment obtained after Baseline (Visit 2/Day 0) whilst on investigational product and ...
  https://clinicaltrials.gov/show/NCT01500694
*  Clonidine to Treat Iatrogenic-induced Opioid Dependence in Infants - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... central alpha 2 agonist) to tapering doses of opioids was efficacious and safe in treating opioid dependence in infants who had ... Specific Aim 2. To determine the pharmacokinetics and pharmacodynamics of clonidine in this critically ill infant population. ... The hypothesis will be tested by addressing 2 specific aims that will determine: 1) the efficacy and safety of clonidine in ...
  https://clinicaltrials.gov/ct2/show/NCT01360450?term=infant+care&recr=Open&fund=0&rank=9
*  The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability - Full Text View - ClinicalTrials.gov
Other Name: Continuous infusion of remifentanil at 0.05 ~ 2 mcg/kg/min with sevoflurane concentration of 1 MAC ... Continuous infusion of remifentanil at 0.05 ~ 2 mcg/kg/min with sevoflurane concentration of 1 MAC ...
  https://clinicaltrials.gov/ct2/show/NCT01634594?recr=Open&cond=%22Jaw%22&rank=13
*  Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients - Full Text View -...
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Up to 2 grams per day of acetaminophen is allowed at the discretion of the principal investigator or his designee. ... Lofexidine HCl 0.2 mg tablets titrated in ascending doses of 0.2 mg (1 tablet) QID starting at 0.4 mg (2 tablets) QID [e.g. Day ... Lofexidine Area Under the Curve (AUC) [ Time Frame: plateau days pre-dose, 0.5, 1 , 2, 3, 4, and 5 hours post dose ]. AUC will ...
  https://clinicaltrials.gov/ct2/show/NCT01650649?recr=Open&intr=methadone&rank=20
*  Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft ...
Adrenergic alpha-2 Receptor Agonists. Adrenergic alpha-Agonists. Adrenergic Agonists. To Top ... Dexmedetomidine is an alpha-2 agonist and reduces the sympathetic tone and neuroendocrine stress response. Dexmedetomidine was ... a bolus dose of Lidocaine 1.5 mg/kg after anesthetic induction with following infusion with 2 mg/kg/hr during the surgery and ... a bolus dose of Lidocaine 1.5 mg/kg after anesthetic induction with following infusion with 2 mg/kg/hr during the surgery and ...
  https://clinicaltrials.gov/ct2/show/NCT01688648?recr=Open&cond=%22Coronary+Artery+Bypass%22&rank=7
*  PeriOperative ISchemic Evaluation-2 Trial - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... or currently taking an alpha-2 agonist, alpha methyldopa, monoamine oxidase inhibitors or reserpine; ... Pre-op (goal 2-4 hours): 2 x 100mg oral tablets. Post-op: patients ingest one tablet a day (100 mg ASA) for 7 days if patient ... Pre-op (goal 2-4 hours): 2 x 100mg oral tablets. Post-op: patients ingest one tablet a day (100 mg ASA) for 7 days if patient ...
  https://clinicaltrials.gov/ct2/show/study/NCT01082874?term=CARDIOVASCULAR+POISE&rank=2&show_locs=Y
*  Cognitive Protection - Dexmedetomidine and Cognitive Reserve - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Contraindication to the use of an 2A-agonist. *Presence of a major psychiatric condition such as bipolar disorder, major ... elective major hip replacement or peripheral vascular (major surgery is defined by a planned 2 day hospitalization) ...
  https://clinicaltrials.gov/ct2/show/NCT00455143
*  Safety, Efficacy and Pharmacokinetic Study of Dexmedetomidine in Pediatrics Ages ≥28 Weeks to ≤44 Weeks Gestational Age - Full...
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... 2014 Feb;164(2):276-82.e1-3. doi: 10.1016/j.jpeds.2013.10.002. Epub 2013 Nov 14. ... Subjects who have a known allergy or contraindication to fentanyl, morphine, Midazolam, DEX, or other α-2 agonists. ...
  https://clinicaltrials.gov/ct2/show/NCT01159262
*  Dexmedetomidine Versus Midazolam for Continuous Sedation in the Intensive Care Unit (ICU) - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Use of centrally acting α2 agonists or antagonists at the time of randomisation, notably clonidine (see section 5.7 for prior ... RASS score will be assessed approximately 2 hourly during the treatment period and during the 48-hour follow-up period ]. * ...
  https://clinicaltrials.gov/ct2/show/NCT00481312
*  Reducing Delirium After Cardiac Surgery: A Multifaceted Approach Of Perioperative Care - Full Text View - ClinicalTrials.gov
... with a new alpha2-adrenergic receptor agonist (dexmedetomidine) possessing sedative, analgesic, and antinociceptive properties ... Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Upon arrival to ICU patients will receive a propofol 2-6mg/kg infusion until tracheal extubation ... Upon arrival to ICU patients will receive a propofol 2-6mg/kg infusion until tracheal extubation ...
  https://clinicaltrials.gov/ct2/show/NCT01378741?recr=Open&cond=%22Delirium%22&rank=17
*  PeriOperative ISchemic Evaluation-2 Trial - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... or currently taking an alpha-2 agonist, alpha methyldopa, monoamine oxidase inhibitors or reserpine; ... PeriOperative ISchemic Evaluation-2 Trial (POISE-2). The safety and scientific validity of this study is the responsibility of ... Pre-op (goal 2-4 hours): 2 x 100mg oral tablets. Post-op: patients ingest one tablet a day (100 mg ASA) for 7 days if patient ...
  https://clinicaltrials.gov/ct2/show/NCT01082874
*  The Effects of Intravenous Dexmedetomidine on Spinal Anesthesia Using Low Dose Diluted Bupivacaine for Transurethral Resection...
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... It has been known that intrathecal addition of alpha-2 adrenergic agents result in prolongation of the duration of the sensory ... Dexmedetomidine is a new selective and potent alpha-2 agonist. It has centrally acting anesthetic properties. ... 0.5% bupivacaine 1.2 mL + normal saline 0.8 mL = total 2 mL. Drug: Dexmedetomidine Dexamedetomidine intravenous injection (1 ㎏/ ...
  https://clinicaltrials.gov/ct2/show/NCT01224470
*  Clonidine for Relapse Prevention in Buprenorphine-Maintenance Patients - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Sildenafil citrate (Viagra). Sildenafil citrate doses , 25mg should not be taken within 4 hours of taking an alpha blocker or ... stress-induced relapse to heroin and cocaine seeking is blocked by the alpha-2 adrenergic agonist clonidine. In this study, ... 4 hrs from when an alpha blocker could be taken after Viagra ingestion. ...
  https://clinicaltrials.gov/ct2/show/NCT00295308?term=%22High+Blood+Pressure%22&lup_s=01%2F26%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14
*  Guanfacine in Children With Tic Disorders - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Prior failed treatment with an adequate trial of guanfacine in last 2 years. ...
  https://clinicaltrials.gov/show/NCT01547000
*  Assessment of the Effect of Clonidine for Cataract Surgery - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Clonidine, an agonist for alfa2 pre-synaptic, has been shown to be an effective adjuvant therapy for acute postoperative pain ... To detect difference in pain intensity of 3 between the groups by NRS, with 95% of power (estimated SD= 2.0), when the alpha ... Group 2, patients will receive a single dose of 4mcg.kg-1 of clonidin2, 20 minutes before the surgical incision; group 1, ...
  https://clinicaltrials.gov/ct2/show/NCT01677351?recr=Open&cond=%22Arrhythmias%2C+Cardiac%22&rank=19
*  Safety and Efficacy of Brimonidine Intravitreal Implant in Patients With Geographic Atrophy Due to Age-related Macular...
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Stage 2 will begin after 1 month of safety has been evaluated for Stage 1. Stage 2 is a randomized, double-masked, dose- ... Stage 2: 400 µg brimonidine tartrate implant in the study eye and sham in the fellow eye on Day 1 and Month 6. ... Stage 2: 200 µg brimonidine tartrate implant in the study eye and sham in the fellow eye on Day 1 and Month 6. ...
  https://clinicaltrials.gov/ct2/show/NCT00658619
*  Dexmedetomidine in Patients After Intracranial Surgery - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Dexmedetomidine is a highly selective a2-adrenoreceptor agonist that produces dose-dependent sedation and analgesia without ... The study is designed primarily to compare the percentage of patients with agitation and requiring midazolam infusion in the 2 ...
  https://clinicaltrials.gov/ct2/show/NCT01445639?recr=Open&cond=%22Nervous+System+Diseases%22&rank=17
*  Lofexidine for Inpatient Opiate Detox - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Lofexidine is an alpha2-adrenergic-agonist with mild to moderate antihypertensive actions. It is mainly used in the alleviation ... Have a score greater than or equal to 2 on the Objective Opiate Withdrawal Scale-Handelsman (OOWS) immediately prior to ... 2 above), anticonvulsants, antihypertensives, antiarrhythmics, antiretroviral, and cholesterol lowering medications. Nicotine ...
  https://clinicaltrials.gov/ct2/show/NCT00235729
*  Effect of Clonidine on Responses to Imagery Scripts - Full Text View - ClinicalTrials.gov
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... and drug abusers and society may benefit from the eventual use of clonidine or other alpha agonists for prevention of relapse ... Alpha-2 adrenergic agonists, such as clonidine, have been shown to block stress-induced relapse, but not cue-induced relapse, ... Endocrine responses (salivary cortisol and salivary alpha-amylase) [ Time Frame: 1 hr ]. ...
  https://clinicaltrials.gov/ct2/show/NCT00318760?recr=Open&cond=%22Heroin+Dependence%22&rank=20
*  Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care...
Adrenergic alpha-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents. Molecular Mechanisms of ... Alpha-2 Agonists: Xylazine*, Clonidine (Catapres, Dixarit), Guanfacine (Tenex), Guanabenz (Wytensin), Mivazerol, Guanadrel ( ... Alpha-2 Antagonists: Corynanthine, Phenoxybenzamine (Dibenzyline), Phentolamine (Regitine, Rogitine), Tolazoline (Priscoline), ... Subjects who will require alpha-2 agonists/antagonists listed below within 48 hrs prior to baseline. ...
  https://clinicaltrials.gov/ct2/show/NCT00875550