Molecules | Free Full-Text | The Power of LC-MS Based Multiomics: Exploring Adipogenic Differentiation of Human Mesenchymal...
In this work, we used human MSCs, received from surgery waste, and differentiated them into fat adipocytes. The combination of ... Comparing MSCs and adipocytes, we observed significant regulation of different metabolites and lipids such as triglycerides, ... Mesenchymal stem/stromal cells (MSC) are the ideal source to study fat formation as they are the progenitors of adipocytes. ... 2.4.3. Trigylcerides Upregulation in Lipid Droplets of Adipocytes. A major increase of TGs in adipocytes was observed in the ...
Toxins | Free Full-Text | Indoxyl Sulfate Contributes to Adipose Tissue Inflammation through the Activation of NADPH Oxidase
Co-culturing 3T3L-1 adipocytes and mouse macrophage cells showed incubating adipocytes with IS increased macrophage ... production in the differentiated 3T3L-1 adipocyte. An organic anion transporter (OAT) inhibitor, an NADPH oxidase inhibitor or ... Differentiated 3T3-L1 adipocytes and RAW264.7 macrophages were co-cultured in Transwell® plates (differentiated adipocytes were ... Differentiated 3T3-L1 adipocytes and RAW264.7 macrophages were co-cultured in Transwell® plates (differentiated adipocytes were ...
IJMS | Free Full-Text | The Epigenetic Overlap between Obesity and Mood Disorders: A Systematic Review
Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression. Adipocyte 2017, 6, 124- ...
Biomolecules | Free Full-Text | The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention
Reduced proliferation of 3T3-L1 adipocytes. Inhibited proliferation of pre-adipocytes through transcription factors and ... 39] claim that EO polyphenols reduce the accumulation of lipids in adipocyte cells by a reduction of the genetic expression of ... Reduced intracellular lipids accumulation during adipocyte differentiation in a dose-dependent manner and decrease in the ... adipocyte fatty acid-binding protein 2, lipoprotein lipase, fatty acid transport proteins, fatty acid synthase, leptin, total ...
IJMS | Free Full-Text | Curcumin and Weight Loss: Does It Work?
It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte ... White adipocytes (white adipose tissue-WAT) and brown adipocytes (brown adipose tissue-BAT) are the main mature adipocytes [1 ... Rabbit subcutaneous adipocytes treated with curcumin (0-20 μg/mL). ↑Cholesterol efflux from adipocytes. ↑PPARγ, LXRα, ABCA1. 24 ... Wnt signaling in mature adipocytes. ↓Inflammatory in. adipocytes. 28 weeks. [113]. Animal study. European obese cats (6.5 years ...
Cells | Free Full-Text | Processing and Ex Vivo Expansion of Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells for the...
Representative images of AT-MSCs differentiated into osteoblasts, chondroblasts, and adipocytes. AT-MSCs were cultured using a ... Representative images of AT-MSCs differentiated into osteoblasts, chondroblasts, and adipocytes. AT-MSCs were cultured using a ... and adipocytes [5]. It has been shown that BM-derived MSCs (BM-MSCs) differentiating into chondrocytes also secrete ... whereas AT-MSCs were differentiated into adipocytes for 11 days in tissue-specific differentiation media. We found that AT-MSCs ...
IJMS | October 2011 - Browse Articles
In our laboratory we used 3T3-L1 preadipocytes, which are able to differentiate into mature adipocytes and accumulate lipids, ... N-Acetylcysteine Reduces Markers of Differentiation in 3T3-L1 Adipocytes by Pablo Calzadilla ...
IJMS | August-2 2020 - Browse Articles
3) Results: We noted a large number of adipocyte genes were altered in experimental renal failure. Adipocyte specific NaKtide ... In the murine adipocytes, both IS and oxLDL induced similar pathway changes as were noted in vivo, and pNaKtide appeared to ... Oxidant-Induced Alterations in the Adipocyte Transcriptome: Role of the Na,K-ATPase Oxidant Amplification Loop by Komal Sodhi ... In mice, a high-fat diet increases adipocyte ATX production. ATX production in obesity is also increased because of low-level ...
IJMS | June 2018 - Browse Articles
Thermogenic adipocytes are capable of burning fat to dissipate chemical energy into heat, thereby enhancing energy expenditure ... Co-Expression Network Analysis of AMPK and Autophagy Gene Products during Adipocyte Differentiation by Mahmoud Ahmed ... It is essential for the pre-adipocytes to respond to the differentiation stimuli and may contribute to reorganizing the ... It is essential for the pre-adipocytes to respond to the differentiation stimuli and may contribute to reorganizing the ...
Nutrients | Free Full-Text | Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition...
Enlarged adipocyte size was observed in women with PCOS. The same study described lower serum adiponectin in patients with PCOS ... Ek and co-authors reported a marked increase in catecholamine-induced adipocyte lipolysis in PCOS women and a significant ... The lipotoxicity theory implies that lipids stored in adipocytes in the form of triglyceride are biologically inert, and that ... Furthermore, an inverse correlation was noted between the size of visceral adipocytes and the amount of adiponectin released. ...
JCM | Free Full-Text | Human Wharton's Jelly-Cellular Specificity, Stemness Potency, Animal Models, and Current Application in...
The latter, however, are more successful in adipocyte formation [66].. The potential of these cells to transform into cardiac ... adipocytes, and chondroblasts [46]. MSCs were isolated for the first time from the bone marrow by Friedenstein et al. [3] and, ... adipocytes and chondroblasts is required for WJ-derived cells to be considered mesenchymal stem cells [46], such ... adipocytes, cardiomyocytes, skeletal muscle cells, or endothelial cells. Transformation of WJ-MSCs into neurons, which are of ...
Molecules | Free Full-Text | The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease
Increased input or synthesis of TGs includes increased dietary intake, increased lipolysis from adipocytes, and increased de ... Study showed that BBR acutely activated AMPK in both L6 myotubes and 3T3-L1 adipocytes [32]. Both central and peripheral ... Activation of ampk by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes. Febs Lett. 2011, 585, 1735-1740. [ ... translocation to the cell membrane in myotubes and decreasing lipid mass in adipocytes [32]. In addition, insulin signaling ...
Cells | Free Full-Text | Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia
Promotion of adipocyte and musclefibre catabolism.Reduction of lipid accumulation. Exosomes from human breast cancer cells (4T1 ... Sun, D.; Ding, Z.; Shen, L.; Yang, F.; Han, J.; Wu, G. miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in ... Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer. ... demonstrated that breast cancer cell-secreted miR-155 promotes catabolism in resident adipocytes by downregulating the PPAR-γ ...
IJMS | Free Full-Text | Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders
Wernstedt, A.I.; Tao, C.; Morley, T.S.; Wang, Q.A.; Delgado-Lopez, F.; Wang, Z.V.; Scherer, P.E. Adipocyte inflammation is ...
Surgeries | Free Full-Text | Ionizing Radiation Mediates Dose Dependent Effects Affecting the Healing Kinetics of Wounds...
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Cell Stem Cell 2020, 26, 880- ... The latter may be related to the transdifferentiation of adipocytes into myofibroblasts, a process described in the fibrotic ... and the adipocytes of the dermal white adipose tissue (dWAT) appears as blank spaces (Figure 3). Measurements of the thickness ... Impact of tissue-engineered biological dressings featuring human differentiated adipocytes. Acta Biomater. 2015, 22, 39-49. [ ...
Processes | Free Full-Text | A Newly Designed EGFP-2A Peptide Monocistronic Baculoviral Vector for Concatenating the Expression...
Trujillo, M.E.; Scherer, P.E. Adiponectin--journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. ...
Genes | Special Issue : miRNA Regulation
We examined NEAT1 RNA levels and its function in 3T3-L1 cells during differentiation to adipocytes. Levels of NEAT1 transcript ... differentiation occurs The appearance of PPARγ2 coordinates with the PPARγ1 variant to drive differentiation of adipocytes. ...
Nutrients | Free Full-Text | Daily Vinegar Ingestion Improves Depression Scores and Alters the Metabolome in Healthy Adults: A...
Research has linked increased flux through the hexosamine biosynthetic pathway to insulin resistance in cultured adipocytes [35 ... and the development of insulin resistance in adipocytes. Mol. Cell. Endocrinol. 2010, 318, 44-53. [Google Scholar] [CrossRef][ ...
Toxics | Free Full-Text | Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to...
Watkins, A.M.; Wood, C.R.; Lin, M.T.; Abbott, B.D. The effects of perfluorinated chemicals on adipocyte differentiation in ... acid binds to peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation in 3T3-L1 adipocytes. Biosci ...
Nutrients | Free Full-Text | Plant Sterols as Anticancer Nutrients: Evidence for Their Role in Breast Cancer
Localization of the insulin receptor in caveolae of adipocyte plasma membrane. FASEB J. 1999, 13, 1961-1971. [Google Scholar] ...
Bioengineering | Free Full-Text | Application of Metal Nanoparticle-Hydrogel Composites in Tissue Regeneration
Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes. Int. J. ...
Nutrients | Free Full-Text | Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and...
The plant hormone abscisic acid increases in human plasma after hyperglycemia and stimulates glucose consumption by adipocytes ...
Nutrients | Free Full-Text | Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the...
Bonet, M.; Canas, J.A.; Ribot, J.; Palou, A. Carotenoids and their conversion products in the control of adipocyte function, ...
Life | Free Full-Text | Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective
Hexane Extract of Chloranthus japonicus Increases Adipocyte Differentiation by Acting on Wnt/β-Catenin Signaling Pathway ...
Molecules | Free Full-Text | The Lactoferrin Phenomenon—A Miracle Molecule
... probable downregulation of adipogenic genes and upregulation of fatty acid synthase and acetyl CoA carboxylase in adipocytes) [ ... Lactoferrin increases 172ThrAMPK phosphorylation and insulin-induced p473SerAKT while impairing adipocyte differentiation. Int ... glucose metabolism in patients with type 2 diabetes mellitus via improvement of the insulin-signaling response in adipocytes ( ...
Pharmaceuticals | October 2022 - Browse Articles
Regarding the mature adipocytes markers, GbE enhanced the levels of both FABP4 at D5, and perilipin at D3 and D5. In summary, ... Smaller adipocytes are related to the reversal of metabolic disorders, suggesting that molecules that can act in the ... Smaller adipocytes are related to the reversal of metabolic disorders, suggesting that molecules that can act in the ... 3T3-L1 preadipocytes were differentiated for 7 days into adipocytes without (control group) and with GbE at 1.0 mg/mL. Lipid ...
IJMS | October-1 2022 - Browse Articles
... dependent of and independent of adipocyte-differentiation processes. In the mature white adipocytes after differentiation, LD ... Hypertrophy of white adipocytes is attributed to the excessive storage of the energy form of triglycerides in lipid droplets ( ... Hypertrophy of white adipocytes is attributed to the excessive storage of the energy form of triglycerides in lipid droplets ( ... Hypertrophy and hyperplasia of white adipocytes induce obesity, leading to diseases such as type 2 diabetes and hypertension, ...
IJERPH | Free Full-Text | Mindfulness and Shinrin-Yoku: Potential for Physiological and Psychological Interventions during...
Additionally, serum adiponectin, an adipocyte secreted protein that decreases inflammation in the cardiovascular system, was ...
JCM | Free Full-Text | The Impact of Hormesis, Neuronal Stress Response, and Reproduction, upon Clinical Aging: A Narrative...
Isolation and Culture of Pig Spermatogonial Stem Cells and Their in Vitro Differentiation into Neuron-Like Cells and Adipocytes ...
Molecules | Free Full-Text | Methods for Studying Endocytotic Pathways of Herpesvirus Encoded G Protein-Coupled Receptors
They are enriched in certain cell types such as fibroblasts, smooth muscle cells, endothelial cells, and adipocytes and are ... Shigematsu, S.; Watson, R.T.; Khan, A.H.; Pessin, J.E. The adipocyte plasma membrane caveolin functional/structural ...