2-Alkynyl derivatives of Adenosine-5'-N-ethyluronamide (NECA): selective A2 adenosine receptor agonists with potent inhibitory...
2-Alkynyl derivatives of Adenosine-5'-N-ethyluronamide (NECA): selective A2 adenosine receptor agonists with potent inhibitory ... 2-Alkynyl derivatives of Adenosine-5'-N-ethyluronamide (NECA): selective A2 adenosine receptor agonists with potent inhibitory ... The presence of an a-hydroxyl group in the alkynyl chain of NECA derivatives accounts for the A2 agonist potency, leading to ... The presence of an a-hydroxyl group in the alkynyl chain of NECA derivatives accounts for the A2 agonist potency, leading to ...https://pubblicazioni.unicam.it/handle/11581/241448
A Study to Assess Regadenoson Administration Following an Inadequate Exercise Stress Test as Compared to Regadenoson Alone for...
Adenosine A2 Receptor Agonists. Purinergic P1 Receptor Agonists. Purinergic Agonists. Purinergic Agents. Neurotransmitter ...https://clinicaltrials.gov/ct2/show/study/NCT01618669?term=%22Coronary+Artery+Disease%22&lup_s=09%2F19%2F2013&lup_d=14&show_rss=Y&sel_rss=mod14&show_locs=Y
ADVANCE MPI 1: Study of Regadenoson Versus Adenoscan® in Patients Undergoing Myocardial Perfusion Imaging (MPI) - Full Text...
The investigational drug, regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist, the receptor responsible for ... Purinergic Agonists. Purinergic Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Adenosine A2 ... Adenosine. Regadenoson. Analgesics. Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. ... Adenoscan® (adenosine) is an approved pharmacological stress agent indicated as an adjunct to thallium-201 myocardial perfusion ...https://clinicaltrials.gov/ct2/show/NCT00208299
Comparison of Dobutamine and Regadenoson Stress Cardiac Magnetic Resonance (MR) - Full Text View - ClinicalTrials.gov
Adenosine A2 Receptor Agonists. Purinergic P1 Receptor Agonists. Purinergic Agonists. Purinergic Agents. ... Adrenergic beta-1 Receptor Agonists. Adrenergic beta-Agonists. Adrenergic Agonists. Adrenergic Agents. Neurotransmitter Agents ... Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma ... an adenosine A2A-receptor agonist, in healthy male volunteers. Clin Pharmacokinet. 2006;45(12):1201-12. ...https://clinicaltrials.gov/ct2/show/NCT00763035
A Study of the Safety and Tolerance of Regadenoson in Subjects With Asthma or Chronic Obstructive Pulmonary Disease - Full Text...
Adenosine A2 Receptor Agonists. Purinergic P1 Receptor Agonists. Purinergic Agonists. Purinergic Agents. Neurotransmitter ... Subject started on a course of corticosteroids, steroid combination with long-acting Beta2-agonist (LABA) (oral or inhaled) or ...https://clinicaltrials.gov/ct2/show/NCT00862641?term=Lung+Diseases%2C+Obstructive&rank=10
A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Adenosine A2A Receptor Agonists (0) see Adenosine A2 Receptor Agonists. Adenosine A2A Receptor Antagonists (0) see Adenosine A2 ... Adenosine A2B Receptor Agonists (0) see Adenosine A2 Receptor Agonists. Adenosine A2B Receptor Antagonists (0) see Adenosine A2 ... Adenosine A2 Receptor Agonists (4) • Compounds that selectively bind to and activate ADENOSINE A2 RECEPTORS. MeSH ... Adenosine A2 Receptor Antagonists (8) • Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS. ...https://druginfo.nlm.nih.gov/drugportal/drug/categories
Alcohol in Moderation, Cardioprotection and Neuroprotection: Epidemiological Considerations and Mechanistic Studies
... administration of adenosine A2 receptor agonists, cell-permeant cyclic AMP analogs, or adenylyl cyclase activators (e.g., ... Adenosine A1 receptor blockade abolished the protection, suggesting a role of adenosine A1 receptor in cardioprotection. In ... Sensors include glutamate receptors (notably the NMDA receptor channel), adenosine receptors, and perhaps others coupled to Gi ... Pharmacologic inhibitor studies support this concept and indicated that adenosine A2 receptor occupancy is required for this ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2908373/
Regulation of striatal cyclic-3',5'-adenosine monophosphate accumulation and GABA release by glutamate metabotropic and...
In the absence of adenosine A2 receptor blockade, the mGluR agonist, 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) ... with the latter effect being dependent on the activation of adenosine A2 receptors. A potential physiological role for the ... adenosine monophosphate accumulation and GABA release by glutamate metabotropic and dopamine D1 receptors.. J Wang and K M ... adenosine monophosphate accumulation and GABA release by glutamate metabotropic and dopamine D1 receptors.. J Wang and K M ...http://jpet.aspetjournals.org/content/275/2/877
CGS 21680 | Abcam
... selective A2A agonist. Join researchers using high quality CGS 21680 from Abcam and achieve your mission, faster. ... CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.. J Pharmacol Exp Ther 251:47-55 ... Adenosine receptors and their ligands.. Naunyn Schmiedebergs Arch Pharmacol 362:382-91 (2000). Read more (PubMed: 11111832) » ... Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By research area. Cancer. Cardiovascular. ...http://www.abcam.com/cgs-21680-ab120453.html
The A2b adenosine receptor protects against vascular injury | PNAS
... an in vivo model of smooth muscle cell proliferation revealed that an A2 receptor agonist, 2-octynyladenosine, inhibited ... Although adenosine activates multiple receptor subtypes (A1, A2a, A2b, and A3 receptors), the adenylyl cyclase stimulatory A2a ... adenosine receptors (A2aARs) are regarded mainly as cardioprotective receptors (1). In general, the A2-type receptors have been ... Adenosine A2A Receptor Is Involved in Cell Surface Expression of A2B Receptor ...http://www.pnas.org/content/105/2/792
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Renal actions of a new adenosine agonist, CGS 21680A selective for the A2 receptor. Ka ufen incidence of deep ve- nous ...http://toshan.ru/buy-meds-online-no-prescription/kamagra-in-indien-kaufen.html
Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury | Lung Cellular and Molecular...
Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung. Eur ... Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. ... The adenosine 2A receptor agonist GW328267C improves lung function after acute lung injury in rats. Am J Physiol Lung Cell Mol ... Adenosine protected against pulmonary edema through transporter- and receptor A2-mediated endothelial barrier enhancement. Am J ...http://ajplung.physiology.org/content/306/6/L497
Adenosine and its receptor agonists potentiate nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7...
Enhancement caused by adenosine or its agonists was dose-dependent but the effect was neither A1 nor A2 receptor specific. ... Adenosine and its receptor agonists potentiate nitric oxide synthase expression induced by lipopolysaccharide in RAW 264.7 ... Hon, W.-M., Moochhala, S., Khoo, H.-E. (1997-03-14). Adenosine and its receptor agonists potentiate nitric oxide synthase ... The effect of adenosine and its agonists on nitric oxide synthase (NOS) activity and the production of nitrite induced by ...http://scholarbank.nus.edu.sg/handle/10635/107789
Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration | JACC:...
1992) The effects of intravenous infusions of selective adenosine A1-receptor and A2-receptor agonists on myocardial ... Lower local concentrations of adenosine have been noted to promote neutrophil recruitment (via the A1 and A3 adenosine receptor ... Adenosine bolus did not attenuate neutrophil influx into the no-reflow area, whereas adenosine infusion demonstrated a trend (p ... Whether maximal adenosine dosages were achieved in clinical studies using intravenous adenosine is also unclear. The AMISTAD ( ...http://interventions.onlinejacc.org/content/8/15/1990
Adenosine A2 a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without...
Streptozotocin-induced diabetic rats and corresponding controls were chronically treated with the adenosine A2a AR agonist ... Adenosine A2 a receptor stimulation prevents proteinuria in diabetic rats by promoting an anti-inflammatory phenotype without ... This study investigates whether chronic stimulation of the adenosine A2a receptor (A2a AR) protects kidney function in ...https://www.sigmaaldrich.com/catalog/papers/25891445
Diminished Adenosine A1 Receptor Expression in Pancreatic α-Cells May Contribute to the Pathology of Type 1 Diabetes | Diabetes
Agonist activity of 2- and 5′-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine ... Evidence for an A2-subtype adenosine receptor on pancreatic glucagon secreting cells. Br J Pharmacol 1985;86:565-569pmid: ... The Adora1 receptor is activated by adenosine. In mouse islets, adenosine is released by exocytosis (28) and can act on Adora1 ... The adenosine A1 receptor (Adora1) is a G-protein coupled receptor (GPCR) that is involved in maintaining glucose homeostasis ...http://diabetes.diabetesjournals.org/content/62/12/4208
Epidermal Growth factor potentiates the Transmitter-Induced Stimulation of C-AMP and Inositol Phosphates in Human Pigment...
... carboxamido adenosine), an adenosine A2-receptor agonist. EGF, isoproterenol and NECA have no effect on basal levels of ... receptors in RPE cells. We could find no evidence of an interaction between receptors associated with C-AMP and InsPs/ ... cells by activation of β2-type receptors. Epidermal growth factor (EGF) in contrast does not alter basal levels of C-AMP but ... cell proliferation while isoproterenol is ineffective.The data presented here suggest that after stimulation of EGF receptors, ...http://uir.ulster.ac.uk/15631/
Agonist regulation of cellular Gs α-subunit levels in neuroblastoma × glioma hybrid NG108-15 cells transfected to express...
... equivalent treatments of the cells with agonists at either the A2 adenosine receptor or the secretin receptor have no ... Sustained exposure of the cells to agonists at the IP prostanoid receptor results in a substantial decrease in cellular levels ... 300 fmol/mg of membrane protein of the receptor. Exposure of beta N22 cells to the beta-adrenergic agonist isoprenaline ... 1 nM agonist. Equivalent exposure of beta N17 cells to isoprenaline did not significantly modify levels of any of the G-protein ...http://www.biochemj.org/content/300/3/709
Optical imaging of Ca2+-evoked fluid secretion by murine nasal submucosal gland serous acinar cells - Lee - 2007 - The Journal...
... which could activate adenylyl cyclase via purinergic A2 receptors), 200 μm isoproterenol (a β-adrenergic agonist), and 5 μm ... including the physiological agonists VIP and adenosine) failed to show functional evidence of CFTR activity. One caveat to ... 7B). While the peak [Ca2+]i increase with both agonists was somewhat less than that observed with 100 μm CCh, both agonists ... CFTR is not required for the agonist-stimulated Cl− loss Simultaneous determinations of cell volume and [Ca2+]i (A) or SPQ ...http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2007.131995/full
Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers - Full Text View - ClinicalTrials.gov
Purinergic Agonists. Purinergic Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Adenosine A2 ... An Open-Label, Positron Emission Tomography Study to Assess Adenosine A2A Brain Receptor Occupancy of BIIB014 at Multiple Dose ... occupies the brain's A2A receptors. Receptor occupancy will be assessed by PET scanning using a radiolabelled tracer. ... Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers. The safety and scientific validity of ...https://clinicaltrials.gov/ct2/show/NCT00531193
Adenosine receptor interactions alter cardiac contractility in rat heart
The effect of the adenosine A2 receptor (AdoA2R) agonist N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)-ethyl]adenosine (DPMA) ... on adenosine A1 receptor (AdoA1R)-mediated negative inotropic responses was investigated in rat heart. 2. Hearts from male ... The receptor involved appears to be the AdoA2AR and its action involves stimulation of adenylyl cyclase activity. ... After 30 min equilibration, (R)-N6-phenylisopropyl adenosine (R-PIA) concentration-response curves were constructed in the ...https://research-repository.griffith.edu.au/handle/10072/35828
Molecular probes for adenosine receptors - Patent # 5248770 - PatentGenius
These probes bind to A.sub.2 and A.sub.3 adenosine receptors and aid in quantifying and characterizing the receptors. The ... This application discloses probes for adenosine receptors which are functionalized congeners of the following compound: ##STR1# ... which are agonists for A-1 and A-2 adenosine receptors and the sensitivity for quantitativeanalysis of xanthine amine congeners ... Both adenosine and xanthine derivatives bind competitively to A-1 and A-2 adenosine receptors.. UTILITY STATEMENT. The present ...http://www.patentgenius.com/patent/5248770.html
Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information
Info Adenosine A2 Receptor Agonists. * Info Neurotransmitter Agents. * Info Purinergic Agents. * Info Purinergic P1 Receptor ...https://druginfo.nlm.nih.gov/drugportal/rn/910487-58-0
Regadenoson - DrugBank
Regadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial perfusion imagining ... Adenosine A2 Receptor Agonists. *Cardiac Therapy. *Cardiovascular System. *Neurotransmitter Agents. *Purinergic Agents ... It is a very weak agonist of the A1 adenosine receptor (Ki , 16.5 µM). Furthermore, it has negligible affinity to A2B and A3 ... Regadenoson is an selective low-affinity (Ki= 1.3 µM) A2A receptor agonist that mimics the effects of adenosine in causing ...https://www.drugbank.ca/drugs/DB06213
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