A Comparison of the Antagonist Affinities for the Gi- and Gs-Coupled States of the Human Adenosine A1-Receptor | Journal of...
... conformations of the adenosine A1-receptor in Chinese hamster ovary cells stably expressing the human adenosine A1-receptor and ... A Comparison of the Antagonist Affinities for the Gi- and Gs-Coupled States of the Human Adenosine A1-Receptor. Jillian G. ... A Comparison of the Antagonist Affinities for the Gi- and Gs-Coupled States of the Human Adenosine A1-Receptor. Jillian G. ... A Comparison of the Antagonist Affinities for the Gi- and Gs-Coupled States of the Human Adenosine A1-Receptor. Jillian G. ...http://jpet.aspetjournals.org/content/320/1/218
A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Adenosine A1 Receptor Antagonists (3) • Compounds that bind to and block the stimulation of ADENOSINE A1 RECEPTORS. MeSH ... Adenosine A2A Receptor Antagonists (0) see Adenosine A2 Receptor Antagonists. Adenosine A2B Receptor Agonists (0) see Adenosine ... Adenosine A2 Receptor Antagonists (8) • Compounds that selectively bind to and block the activation of ADENOSINE A2 RECEPTORS. ... Adenosine A3 Receptor Antagonists (1). Adenosine Deaminase Inhibitors (8) • Drugs that inhibit ADENOSINE DEAMINASE activity. ...https://druginfo.nlm.nih.gov/drugportal/drug/categories
Frontiers | Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage | Frontiers in Aging Neuroscience
Dennissen, F. J., Anglada-Huguet, M., Sydow, A., Mandelkow, E., and Mandelkow, E. M. (2016). Adenosine A1 receptor antagonist ... blocking M1 and M3 receptors via receptor antagonists can prevent cytotoxic effects (Gómez-Ramos et al., 2008). ... Tau can interact with muscarinic receptors; more specifically, M1 and M3 receptors have approximately a 10-fold higher affinity ... Receptor-Mediated Endocytosis. Tau may be endocytosed, promoting an increase in intracellular calcium that results in neuronal ...https://www.frontiersin.org/articles/10.3389/fnagi.2017.00083/full
Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for...
VT recurred with the addition of aminophylline, a competitive adenosine A1-receptor antagonist. Edrophonium (10 mg i.v.), a ... The antiarrhythmic effects of exogenous adenosine and Valsalva on this form of VT may be due to receptor-mediated inhibition of ... It can be identified by termination of the tachycardia in response to activation of the adenosine A1 or muscarinic cholinergic ... Group 3 (n = 4): Adenosine and vagal maneuvers had no effect on catecholamine-mediated VT caused by automaticity in three of ...http://circ.ahajournals.org/content/87/2/382
Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other...
Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. J Am Soc Nephrol. 1999;10(4):714-20. ... a family of nonspecific adenosine receptor antagonists with several physiological properties, including diuresis and ... Nomenclature and classification of adenosine receptors. Pharmacol Rev. 2001;53(4):527-52.PubMedGoogle Scholar. ... provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels. Mol Pharmacol. 2008;74(4): ...https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0144-4
JC1011 | Percutaneous Coronary Intervention | Cholesterol
Rolofylline is an adenosine A1-receptor antagonist that relieved dyspnea and reduced renal dysfunction in previous studies. In ... Rolofylline, an adenosine A1- receptor antagonist, in acute heart failure. N Engl J Med 2010 Oct 7; 363:1419. ... Celiprolol, a β1-adrenoceptor antagonist with partial β2-adrenoceptor agonist action, has been used for hypertension in various ... Despite the mechanistic appeal of targeting the adenosine pathway and the promising preliminary study results, rolofylline ...https://www.scribd.com/document/96538149/JC1011
The AMEDEO Literature Guide
Nanoconjugate-bound adenosine A1 receptor antagonist enhances recovery of breathing following acute cervical spinal cord injury ... The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection ... The toll-like receptor 2 agonist Pam3CSK4 is neuroprotective after spinal cord injury.. Exp Neurol. 2017 Apr 23. pii: S0014- ... Influence of Urothelial or Suburothelial Cholinergic Receptors on Bladder Reflexes in Chronic Spinal Cord Injured Cats.. Exp ...http://amedeo.com/medicine/nsu/expneuro.htm
Piracetam and Piracetam-Like Drugs | SpringerLink
Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high ... receptor function via protein kinase C activation and reduces magnesium block of NMDA receptor. Mol Pharmacol 2007 Feb;71(2): ... Glutamate receptor dynamics in dendritic microdomains. Neuron 2008 May 22; 58(4): 472-97PubMedCrossRefGoogle Scholar ... Neugebauer V. Glutamate receptor ligands. Handb Exp Pharmacol 2007; 177: 217-49PubMedCrossRefGoogle Scholar ...https://link.springer.com/article/10.2165%2F11319230-000000000-00000
1990 - 1999 : chronologisch : Publikationen : Pharmazie : Universität Hamburg
5'-Deoxy congeners of 9-(3-amido-3-deoxy-β-D-xylofuranosyl)-N6-cyclopentyladenine: New adenosine A1 receptor antagonists. Serge ... noradrenaline and nondegradable adenosine analogs is counteracted by adenosine and ATP in cultured rat hepatocytes. Elke Oetjen ... Opiate und Opiatantagonisten 1. Theoretische Grundlagen der Opioidwirkung (Opiates and opiate antagonists. Part 1. Basic ... Patent: EP 393911 (A1) 1990-10-24 1. Preparation of fungicidal oxazolidinones. Detlef Geffken, Dennis Raymond Rayner. Patent: ...https://www.chemie.uni-hamburg.de/pha/publikationen/1990.html
US6221338B1 - Method of producing particles for use in dry powder inhalers - Google Patents
A1 adenosine receptor antagonists US9522916B2 (en) 2007-12-21. 2016-12-20. Constance Neely Wilson. A1 adenosine receptor ... A1 adenosine receptor antagonists CN100574751C (en) 2002-11-28. 2009-12-30. 贝林格尔英格海姆法玛两合公司. Tiotropium containing powder ... A1 adenosine receptor antagonist for preventing and treating tissue injury and sepsis associated with yersinia pestis infection ... A1 adenosine receptor antagonist for preventing and treating tissue injury and sepsis associated with yersinia pestis infection ...https://patents.google.com/patent/US6221338B1/en
Rolofylline metabolite M1-trans | A1 antagonist | Compound 3 | CAS [160943-06-6] | Axon 1851 | Axon Ligand™ with |99% purity...
A1 antagonist , Compound 3 , CAS [160943-06-6] , Axon 1851 , Axon Ligand™ with >99% purity available from supplier Axon Medchem ... Adenosine A3 receptor antagonist €120.00 2283 SCH 442416, Desmethyl Radioligand precursor of the adenosine A2A antagonist SCH ... Active metabolite of Rolofylline (Axon 1603), a potent and selective adenosine A1 receptor antagonist ... Adenosine A1 antagonist Chemical name. 8-(Hexahydro-7-hydroxy-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-1H-Purine ...https://www.axonmedchem.com/product/1851
Adenosine A1 receptor - Wikipedia
... an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal ... The adenosine A1 receptor is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as ... The adenosine A1 receptor has been found to be ubiquitous throughout the entire body. Activation of the adenosine A1 receptor ... "Adenosine Receptors: A1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology ...https://en.wikipedia.org/wiki/Adenosine_A1_receptor
Dipropylcyclopentylxanthine - Wikipedia
... is a drug which acts as a potent and selective antagonist for the adenosine A1 receptor. It has high selectivity for A1 over ... "Potent adenosine receptor antagonists that are selective for the A1 receptor subtype". Molecular Pharmacology. 31 (3): 247-52. ... Chwalczuk K, Rubaj A, Swiader M, Czuczwar SJ (2008). "[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 , ... a selective high affinity antagonist radioligand for A1 adenosine receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. ...https://en.wikipedia.org/wiki/Dipropylcyclopentylxanthine
Rolofylline - Wikipedia
Rolofylline (KW-3902) is an experimental diuretic which acts as a selective adenosine A1 receptor antagonist. It was discovered ... an adenosine A1-receptor antagonist, on diuresis and renal function in patients with acute decompensated heart failure and ... dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal ...https://en.wikipedia.org/wiki/Rolofylline
GP 4012 - AdisInsight
Adenosine A1 agonists have potent neuroprotective properties. However, their therapeutic potential is limited by cardiovascular ... Mechanism of Action Adenosine A1 receptor agonists; Adenosine A1 receptor antagonists * Orphan Drug Status Orphan designation ...http://adisinsight.springer.com/drugs/800010634?error=cookies_not_supported&code=6eac34a8-30d0-4ff7-b0d5-edaddfa89e42
medication | AudioMedica.com
The adenosine A1-receptor antagonist rolofylline appears to prevent renal impairment and improve acute heart failure symptoms. ... with advanced non-small cell lung cancer treated with a monoclonal antibody targeted to the epidermal growth factor receptor: ...http://www.audiomedica.com/tag/medication/
Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep...
Adenosine A1 receptor antagonist mitigates deleterious effects of sleep deprivation on adult neurogenesis and spatial reference ... of interleukins and tumor necrosis factor for each group was done by employing RT2 Profiler inflammatory cytokines and receptor ... cell proliferation in the hippocampus of adult mice is eliminated by corticosterone clamp combined with interleukin-1 receptor ...https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0998-z
Sevoflurane Preconditioning against Focal Cerebral Ischemia:Inhibition of Apoptosis in the Face of Transient Improvement of...
Isoflurane tolerance against focal cerebral ischemia is attenuated by adenosine A1 receptor antagonists. Can J Anaesth 2006; 53 ... For example, activation of adenosine A1 receptors31 and adenosine triphosphate-sensitive potassium channels,32 through reactive ... Kersten JR, Orth KG, Pagel PS, Mei DA, Gross GJ, Warltier DC: Role of adenosine in isoflurane-induced cardioprotection. ... Activation of Adenosine Triphosphate-regulated Potassium Channels during Reperfusion Restores Isoflurane Postconditioning- ...http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1940748
Bamifylline - Wikipedia
Bamifylline is a drug of the xanthine chemical class which acts as a selective adenosine A1 receptor antagonist. Theophylline ... "Effects of A1 adenosine receptor blockade by bamiphylline on ischaemic preconditioning during coronary angioplasty" (PDF). ...https://en.wikipedia.org/wiki/Bamifylline
Cardiac Literature, including Myocardial Infarction, arrthymias, tachycardia, and angina sub-cluster 40
Comparison of three different A1 adenosine receptor antagonists on infarct size and ... ... A(1) adenosine receptor (AR) antagonists are effective diuretic agents that may be useful for treating fluid retention ... STUDY OBJECTIVE: To investigate the effects of the angiotensin II subtype 1 receptor (AT1R) antagonist losartan on functional ... Effects of the angiotensin II subtype 1 receptor antagonist losartan on functional ... ...http://www.biomedsearch.com/cluster/1/Cardiac-Literature-including-Myocardial-Infarction-arrthymias-tachycardia-and-angina/sub-40-p10.html
SF 349 - AdisInsight
Mechanism of Action Adenosine A1 receptor antagonists * Orphan Drug Status Orphan designation is assigned by a regulatory body ...http://adisinsight.springer.com/drugs/800011036?error=cookies_not_supported&code=f46bf7be-41c8-4076-8c5d-14aea21cd64b
Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus.
Receptor, Adenosine A1 / antagonists & inhibitors. Sleep / physiology. Synapses / drug effects, physiology*. Wakefulness / ... LTP in VLPO-lesioned animals was partially restored by adenosine antagonists, suggesting that adenosine accumulation in VLPO- ... rats is associated with greater ligand accumulation rather than a change in adenosine receptor sensitivity or adenosine- ... hippocampal slices from VLPO-lesioned rats showed a greater response to adenosine antagonists and greater paired-pulse ...http://www.biomedsearch.com/nih/Long-term-synaptic-plasticity-impaired/20128848.html
KAKEN - Research Projects | Mechanisms of development of ischemic neuronal cell death and protection against ischemic neuronal...
Moreover, CHA, an adenosine A1 receptor antagonist and CGS-21680, an adenosine A2 receptor antagonist, were also effective in ... adenosine / dementia / gerbil / ischemia / neuroprotection / primary culture / adenosine / AMP / ATP / A1 receptor / cortex / ... This selective damage was attenuated by MK-801, a NMDA receptor antagonist and L-NAME, a nitric oxide synthase inhibitor. ... This cell death was attenuated by treatment of MK-801, L-NAME, adenosine, CHA and CGS-21680. CHA reduced hypoxia/hypoglycemia- ...https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14572088/
Acute congestive heart failure legal definition of acute congestive heart failure
NovaCardia's lead product candidate KW-3902, an adenosine A1 receptor antagonist, is being studied in Phase 3 clinical trials ...http://legal-dictionary.thefreedictionary.com/acute+congestive+heart+failure
Experts and Doctors on aged in Durham, United States
The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist ... purinergic p2y receptor antagonists*extramammary pagets disease*outcome assessment health care*coronary artery disease*hospital ... androgen receptor products*BRCA2 products*LOXL1 products*S100B products*Smad4 products*P-selectin products*VEGF products*IGFBP- ... Trinucleotide repeat polymorphisms in the androgen receptor gene and risk of ovarian cancer. Cancer Epidemiol Biomarkers Prev. ...http://www.labome.org/locale/united/north/experts-and-doctors-on-aged-in-durham--united-states-4968.html