KEGG PATHWAY: FoxO signaling pathway - Homo sapiens (human)
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events ... In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), ... in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO ... upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated ...http://www.kegg.jp/kegg-bin/show_pathway?hsa04068+5170
The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Lo, L. C., Tiveron, M. C. and Anderson, D. J. (1998). MASH1 activates expression of the paired homeodomain transcription factor ... One of the most interesting properties of the Phox2 transcription factors is their ability to directly activate the ... The bHLH transcription factor Hand2 belongs to the network of regulatory factors implicated in the specification and ... The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ...http://dev.biologists.org/content/133/20/4015
Biomedicines | Free Full-Text | Decoding the Pluripotency Network: The Emergence of New Transcription Factors | HTML
In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors ... Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, ... These core transcription factors work in combination to further activate other pluripotency-related genes through feed-forward ... 4. Kruppel-Like (Klf) Transcription Factors. The Klf family is a set of zinc finger transcription factors, which consist of 17 ...http://www.mdpi.com/2227-9059/1/1/49/htm
Neurogenin-3 - Wikipedia
transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ... positive regulation of sequence-specific DNA binding transcription factor activity. • negative regulation of transcription from ... transcription from RNA polymerase II promoter. • transcription, DNA-templated. • nervous system development. • regulation of ... Sommer L, Ma Q, Anderson DJ (1996). "neurogenins, a novel family of atonal-related bHLH transcription factors, are putative ...https://en.wikipedia.org/wiki/NEUROG3
The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development
... onset of myogenic progression in the cephalic mesoderm and mesodermal core of first BA and activates the transcription factors ... The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development Public Deposited ... Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and ... Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and ...https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/b5644w68k
The Expression of the Regulatory T Cell-Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in...
Detection of Treg is hampered by the problem that these cells share a set of markers with either memory or activated T cells. ... Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299: ... The Expression of the Regulatory T Cell-Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in ... The Expression of the Regulatory T Cell-Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in ...http://clincancerres.aacrjournals.org/content/11/23/8326
FOXL2 elisa kit | Canine Forkhead box protein L2 (FOXL2) ELISA Kit-NP 075555.1
Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Defects in FOXL2 are a cause ... transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; positive regulation of ... This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ... Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 3q23. Cellular Component: nucleus. ...https://www.mybiosource.com/prods/ELISA-Kit/Canine/Forkhead-box-protein-L2-FOXL2/FOXL2/datasheet.php?products_id=7200093
FOXO4 - Wikipedia
Tang TT, Dowbenko D, Jackson A, Toney L, Lewin DA, Dent AL, Lasky LA (2002). "The forkhead transcription factor AFX activates ... FOXO transcription factors have been shown to be the down downstream effector molecules of insulin-like growth factor (IGF) ... Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 ... transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1". J. Leukoc ...https://en.wikipedia.org/wiki/FOXO4
Activating Transcription Factors - Medical Dictionary online-medical-dictionary.org
Activating Transcription Factors. Activating Transcription Factors were originally identified as DNA-Binding Proteins that ... They are a Family of Basic Leucine Zipper Transcription Factors that bind to the Consensus site TGACGTCA of the Cyclic AMP ...http://www.online-medical-dictionary.org/definitions-a/activating-transcription-factors.html
A Basal Transcription Factor That Activates or Represses Transcription | Science
A Basal Transcription Factor That Activates or Represses Transcription Message Subject. (Your Name) has forwarded a page to you ... A Basal Transcription Factor That Activates or Represses Transcription. By Patricia J. Willy, Ryuji Kobayashi, James T. ... A Basal Transcription Factor That Activates or Represses Transcription. By Patricia J. Willy, Ryuji Kobayashi, James T. ... is a bifunctional basal transcription factor that differentially regulates gene transcription through DPE or TATA box motifs. ...http://science.sciencemag.org/content/290/5493/982
ATF3 Activating Transcription Factor 3 | Springer for Research & Development
A cellular protein, activating transcription factor, activates transcription of multiple E1a-inducible adenovirus early ... Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol. 2007;179:3622-30.PubMedCrossRef ... Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages. Mol Immunol. 2007;44:1598-605. ... The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its ...https://rd.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_612
Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response | Cancer Research
Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response. Chunhong Yan, Tsonwin Hai and Douglas Boyd ... Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response Message Subject (Your Name) has forwarded a page ... As a consequence, target genes including p21, PIG3 or PUMA are transcriptionally activated, leading to cell growth arrest or ... ATF3-stabilized p53 was functional as evidenced by its ability to trans-activate p53 downstream targets including MDM2, p21, ...http://cancerres.aacrjournals.org/content/65/9_Supplement/862.3
Activating transcription factor - Wikipedia
Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a ... "Classification of Human Transcription Factors (TFClass)". Activating Transcription Factors at the US National Library of ... Karin M1, Smeal T (1992). "Control of transcription factors by signal transduction pathways: the beginning of the end". Trends ... whereas it turned out later that some of them might be more similar to AP-1-like factors such as c-Jun or c-Fos. Genes include ...https://en.wikipedia.org/wiki/Activating_transcription_factor
Activating transcription factor 2 - Wikipedia
Activating transcription factor 2, also known as ATF2, is a protein that, in humans, is encoded by the ATF2 gene. This gene ... Activating transcription factor 2 has been shown to interact with C-jun, Casein kinase 2, alpha 1, CREB binding protein, ... "Phosphorylation of two eukaryotic transcription factors, Jun dimerization protein 2 and activation transcription factor 2, in ... Activating transcription factor GRCh38: Ensembl release 89: ENSG00000115966 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...https://en.wikipedia.org/wiki/Activating_transcription_factor_2
iHOP - ISGF3 gamma p48, a specificity switch for interferon activated transcription factors.
iHOP - Information Hyperlinked over Proteins. iHOP provides the network of genes and proteins as a natural way of accessing the millions of abstracts in PubMed. By employing genes and proteins as hyperlinks between sentences and abstracts, the information in PubMed becomes bound together into one navigable resource. A Gene Network for Navigating the Literature, Nature Genetics 36, 664 (2004). www.ihop-net.org/UniPub/iHOP/http://www.ihop-net.org/UniPub/iHOP/pm/794535.html?nr=3&pmid=8864350
CiNii 論文 - Decreased immediate inflammatory gene induction in activating transcription factor...
Decreased immediate inflammatory gene induction in activating transcription factor-2 mutant mice * * REIMOLD Andreas M. ... Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes BEIER F. ... Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9 Implication of the ... A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein LIU ...http://ci.nii.ac.jp/naid/10008033160
NIOSHTIC-2 Publications Search - 20035352 - Induction of metallothionein I by arsenic via metal-activated transcription factor...
Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. ... Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. ... Induction of metallothionein I by arsenic via metal-activated transcription factor 1. Critical role of c-terminal cysteine ... The findings demonstrate a critical role of the C-terminal cysteine cluster of MTF1 in arsenic sensing and gene transcription ...https://www.cdc.gov/niosh/nioshtic-2/20035352.html
NIOSHTIC-2 Publications Search - 20029921 - Chromium (VI) induces antioxidant gene HO-1 by activating the CNC BZIP...
Chromium (VI) induces antioxidant gene HO-1 by activating the CNC BZIP transcription factor NRF2.. ... Expression of a dominant negative form of Nrf2, a cap 'n' collar basic leucine zipper transcription factor, in the cells blocks ... implicating Nrf2 as the key transcription factor in the induction. Mechanistic analysis reveals that Cr (VI) increases the ... These results provide the first evidence that Cr (VI) induces antioxidant gene HO-1 important in ROS defense by activating Nrf2 ...https://www.cdc.gov/niosh/nioshtic-2/20029921.html
High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5. - PubMed - NCBI
High-yield expression in E. coli and refolding of the bZIP domain of activating transcription factor 5.. Ciaccio NA1, Moreno ML ... Activating transcription factor 5 (ATF5) recently has been demonstrated to play a critical role in promoting the survival of ... High-Yield Expression in E. coli and Refolding of the bZIP Domain of Activating Transcription Factor 5 ... High-Yield Expression in E. coli and Refolding of the bZIP Domain of Activating Transcription Factor 5 ...https://www.ncbi.nlm.nih.gov/pubmed?term=18718539
THE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCER
... ... ATF3, a member of the ATF/CREB transcription factor family, plays an important role on regulation of apoptosis and is regarded ... related transcription factors. However, mammosphere forming assay indicated that ATF3 overexpressed colon cancer cells form ...https://drum.lib.umd.edu/handle/1903/17382
atf7ip2, activating transcription factor 7 interacting protein 2 - Creative Biogene
ATF7IP2; activating transcription factor 7 interacting protein 2; activating transcription factor 7-interacting protein 2; ... FLJ12668; ATF7-interacting protein 2; MBD1-containing chromatin associated factor 2; MBD1-containing chromatin-associated ...https://www.creative-biogene.com/symbolsearch_atf7ip2.html
Failure to Activate Transcription Factor NF-κB in Corneal Stromal Cells (Keratocytes) | IOVS | ARVO Journals
IL-1 activates transcription of the gene for IL-1α via a pathway requiring ROS and transcription factor NF-κB, while activation ... Failure to Activate DNA Binding of Transcription Factor NF-κB: Role in Determining the Incompetent Phenotype ... Jeffery R. Cook, Mehernosh K. Mody, M. Elizabeth Fini; Failure to Activate Transcription Factor NF-κB in Corneal Stromal Cells ... Failure to Activate Transcription Factor NF-κB in Corneal Stromal Cells (Keratocytes) ...https://iovs.arvojournals.org/article.aspx?articleid=2123275
"Contribution of Activating Transcription Factor 3 to development of ac" by Jelena Toma
Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to ... The highest risk factor for PDAC is recurrent pancreatitis. While the link between PDAC and pancreatitis is unknown, de- ... Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to ... Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia ...https://ir.lib.uwo.ca/etd/4719/
IJMS | Free Full-Text | p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression...
... and diminished MMP-2 transcription and protein levels in hypoxic conditions as compared to control. Taken together, hYSK1 ... Lee, M.-H.; Kundu, J.K.; Choi, B.Y. p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 ... p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions. ... p21WAF1/Cip1 Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions. ...https://www.mdpi.com/1422-0067/20/2/310
Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN...
activating transcription factor. eIF2α. eukaryotic initiation factor 2α. ER. endoplasmic reticulum. HA. hemagglutinin. ID. ... biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors ... Mitosin/CENP-F as a negative regulator of activating transcription factor-4. J. Biol. Chem. 280: 13973-13977. ... Activating transcription factor 4. Int. J. Biochem. Cell Biol. 40: 14-21. ...http://www.jimmunol.org/content/186/2/1001