KEGG PATHWAY: FoxO signaling pathway - Homo sapiens (human)
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events ... In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), ... in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO ... upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated ...http://www.kegg.jp/kegg-bin/show_pathway?hsa04068+5170
The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons | Development
Lo, L. C., Tiveron, M. C. and Anderson, D. J. (1998). MASH1 activates expression of the paired homeodomain transcription factor ... One of the most interesting properties of the Phox2 transcription factors is their ability to directly activate the ... The bHLH transcription factor Hand2 belongs to the network of regulatory factors implicated in the specification and ... The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a ...http://dev.biologists.org/content/133/20/4015
Biomedicines | Free Full-Text | Decoding the Pluripotency Network: The Emergence of New Transcription Factors | HTML
In this review, we would like to summarize the recent advancements in the accumulating findings of new transcription factors ... Beside the core Oct4-Sox2-Nanog circuitry, accumulating regulators, including transcription factors, epigenetic modifiers, ... These core transcription factors work in combination to further activate other pluripotency-related genes through feed-forward ... 4. Kruppel-Like (Klf) Transcription Factors. The Klf family is a set of zinc finger transcription factors, which consist of 17 ...http://www.mdpi.com/2227-9059/1/1/49/htm
Neurogenin-3 - Wikipedia
transcription factor activity, sequence-specific DNA binding. • transcription coactivator activity. • transcriptional activator ... positive regulation of sequence-specific DNA binding transcription factor activity. • negative regulation of transcription from ... transcription from RNA polymerase II promoter. • transcription, DNA-templated. • nervous system development. • regulation of ... Sommer L, Ma Q, Anderson DJ (1996). "neurogenins, a novel family of atonal-related bHLH transcription factors, are putative ...https://en.wikipedia.org/wiki/NEUROG3
The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development
... onset of myogenic progression in the cephalic mesoderm and mesodermal core of first BA and activates the transcription factors ... The function of the homeobox transcription factor Pitx2 during mammalian skeletal muscle development Public Deposited ... Homeodomain transcription factors control developmental processes. They pattern body formation, specify cell lineages and ... Pitx2, a bicoid-related homeodomain transcription factor, is asymmetrically expressed in the left lateral plate mesoderm and ...https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/b5644w68k
The Expression of the Regulatory T Cell-Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in...
Detection of Treg is hampered by the problem that these cells share a set of markers with either memory or activated T cells. ... Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299: ... The Expression of the Regulatory T Cell-Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in ... The Expression of the Regulatory T Cell-Specific Forkhead Box Transcription Factor FoxP3 Is Associated with Poor Prognosis in ...http://clincancerres.aacrjournals.org/content/11/23/8326
FOXL2 elisa kit | Canine Forkhead box protein L2 (FOXL2) ELISA Kit-NP 075555.1
Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Defects in FOXL2 are a cause ... transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; positive regulation of ... This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ... Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 3q23. Cellular Component: nucleus. ...https://www.mybiosource.com/prods/ELISA-Kit/Canine/Forkhead-box-protein-L2-FOXL2/FOXL2/datasheet.php?products_id=7200093
FOXO4 - Wikipedia
Tang TT, Dowbenko D, Jackson A, Toney L, Lewin DA, Dent AL, Lasky LA (2002). "The forkhead transcription factor AFX activates ... FOXO transcription factors have been shown to be the down downstream effector molecules of insulin-like growth factor (IGF) ... Tang TT, Lasky LA (2003). "The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 ... transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1". J. Leukoc ...https://en.wikipedia.org/wiki/FOXO4
ATF3 Activating Transcription Factor 3 | Springer for Research & Development
A cellular protein, activating transcription factor, activates transcription of multiple E1a-inducible adenovirus early ... Negative regulation of TLR-signaling pathways by activating transcription factor-3. J Immunol. 2007;179:3622-30.PubMedCrossRef ... Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages. Mol Immunol. 2007;44:1598-605. ... The induction of STAT1 gene by activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its ...https://rd.springer.com/referenceworkentry/10.1007%2F978-3-319-67199-4_612
Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response | Cancer Research
Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response. Chunhong Yan, Tsonwin Hai and Douglas Boyd ... Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response Message Subject (Your Name) has forwarded a page ... As a consequence, target genes including p21, PIG3 or PUMA are transcriptionally activated, leading to cell growth arrest or ... ATF3-stabilized p53 was functional as evidenced by its ability to trans-activate p53 downstream targets including MDM2, p21, ...http://cancerres.aacrjournals.org/content/65/9_Supplement/862.3
THE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCER
... ... ATF3, a member of the ATF/CREB transcription factor family, plays an important role on regulation of apoptosis and is regarded ... related transcription factors. However, mammosphere forming assay indicated that ATF3 overexpressed colon cancer cells form ...https://drum.lib.umd.edu/handle/1903/17382
"Contribution of Activating Transcription Factor 3 to development of ac" by Jelena Toma
Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to ... The highest risk factor for PDAC is recurrent pancreatitis. While the link between PDAC and pancreatitis is unknown, de- ... Contribution of Activating Transcription Factor 3 to development of acinar-to-ductal cell metaplasia ... Our lab has shown that Activating Transcription Factor 3 (ATF3), a factor upregulated during pancreatic injury, contributes to ...https://ir.lib.uwo.ca/etd/4719/
Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene...
A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early ... Immunoblot assays of activating transcription factor (ATF) 3 immunoprecipitates with tyrosine specific antibodies revealed that ... Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene ... Interleukin-10 Induced Activating Transcription Factor 3 Transcriptional Suppression of Matrix Metalloproteinase-2 Gene ...http://mcr.aacrjournals.org/content/2/7/403
A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription...
Activating transcription factor-(ATF-) 3, a stress-inducible transcription factor, is rapidly upregulated under various stress ... Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in ... Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in ... Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in ...http://www.propolisscience.org/propolis-and-cancer/a-taiwanese-propolis-derivative-induces-apoptosis-through-inducing-endoplasmic-reticular-stress-and-activating-transcription-factor-3-in-human-hepatoma-cells/
The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID...
... transcription factors can be recruited to multiple complexes, where they function with diverse co-factors to activate or ... can be activated by multiple lineage-specific transcription factors, instead of by a shared factor in multiple lineages. In ... By interacting with conserved COE binding sites, COE family transcription factors activate or repress the expression of target ... This leads to reduced accessibility to transcription factors and to the downregulation of target transcription in neuronal ...http://dev.biologists.org/content/142/8/1447
Frontiers | Role of Transcription Factors in Peripheral Nerve Regeneration | Frontiers in Molecular Neuroscience
Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... Transcription factors form a vital link in the chain of regeneration, converting injury-induced stress signals into downstream ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ... In this review, we have investigated the functional role of a number of different transcription factors - c-jun, ATF3, CREB, ...https://www.frontiersin.org/articles/10.3389/fnmol.2012.00008/full
The C. elegans COE transcription factor UNC-3 activates lineag...
... elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID lineage.: ... The COE (Collier/Olf/EBF) transcription factors have been implicated in the development of many cell types, including neurons. ... The C. elegans COE transcription factor UNC-3 activates lineage-specific apoptosis and affects neurite growth in the RID ... Unc-3 License. Unknown Abstract. Mechanisms that regulate apoptosis in a temporal and lineage-specific manner remain poorly ...https://www.mysciencework.com/publication/show/c-elegans-coe-transcription-factor-unc-3-activates-lineage-specific-apoptosis-affects-neurite-growth-rid-lineage-28417f78
Dr. Tsonwin Hai - Cancer Researcher at OSUCCC - James
Activating transcription factor 3 regulates canonical TGFß signalling in systemic sclerosis.. Mallano T, Palumbo-Zerr K, Zerr P ... Activating transcription factor 3 regulates chemokine expression in contracting C2C12 myotubes and in mouse skeletal muscle ... Activating transcription factor 3 attenuates chemokine and cytokine expression in mouse skeletal muscle after exercise and ...https://cancer.osu.edu/research-and-education/find-a-researcher/search-researcher-directory/tsonwin-hai
Endoplasmic reticulum stress-induced apoptosis in the development of diabetes: is there a role for adipose tissue and liver? |...
1). ER stress sensors [IRE1 (inositol requiring 1), ATF6 (activated transcription factor 6) and PERK (ER-resident PKR-like eIF2 ... Role for activating transcription factor 3 in stress-induced β-cell apoptosis. Mol Cell Biol 24:5721-5732. doi: 10.1128/mcb. ... The cleaved N-terminal fragment migrates to the nucleus, acts as an active transcription factor, and increases the expression ... Spliced Xbp-1 mRNA encodes a transcription activator that drives transcription of genes such as ER chaperones, whose products ...https://link.springer.com/article/10.1007%2Fs10495-009-0400-4
TLR4 Mediates Pneumolysin-Induced ATF3 Expression through the JNK/p38 Pathway in Streptococcus pneumoniae-Infected RAW 264.7...
Furthermore, ATF3 induction is mediated by p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK). Thus ... The expression of ATF3 was induced by pneumolysin (PLY), a potent pneumococcal virulence factor, via the TLR4 pathway. ... A recent study reported that ATF3 provides protection from Streptococcus pneumoniae infection by activating cytokines. However ... Activating transcription factor-3 (ATF3) acts as a negative regulator of cytokine production during Gram-negative bacterial ...https://www.semanticscholar.org/paper/TLR4-Mediates-Pneumolysin-Induced-ATF3-Expression-Nguyen-Kim/f516d43bcce54b8f1326ac6ee88d681fff4536a3
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional...
Expression of ATF3 (activating transcription factor 3) is induced by a variety of environmental stress conditions, including ... activating transcription factor; bZIP, basic region/leucine zipper; C/EBP, CCAAT/enhancer-binding protein; ChIP, chromatin ... A comparison of the recruitment patterns between ATF and C/EBP transcription factors and RNA polymerase II at the AARE of ... through a highly co-ordinated amino acid-responsive programme of transcription factor synthesis and action. Studies using ...http://www.biochemj.org/content/401/1/299
Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark | BMC Complementary and Alternative Medicine |...
MRBE treatment to SW480 cells activated ATF3 expression and down-regulated cyclin D1 level. We also observed that MRBE-induced ... Activating transcription factor 3 (ATF3) is a member of the ATF/CREB subfamily of the basic-region leucine zipper (bZIP) family ... Wang H, Mo P, Ren S, Yan C: Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to ... Yan C, Lu D, Hai T, Boyd DD: Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. ...https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-200
ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes.
Activating transcription factor 4 (ATF4), a member of the ATF/CREB transcription factor family, is an important factor that ... Activating Transcription Factor 4 / genetics, immunology*, metabolism. Active Transport, Cell Nucleus / drug effects, genetics ... We observed that ATF4 is activated and translocates to the nucleus following lipopolysaccharide (LPS) stimulation via the TLR4- ... 24113138 - Fms-like tyrosine kinase 3 ligand-dependent dendritic cells in autoimmune inflammation.. 24969828 - Knockdown of ...http://www.biomedsearch.com/nih/ATF4-directly-recruited-by-TLR4/23241898.html
Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...
Activating transcription factor 3. ATF3. 287_at. nc. *. a Examined M1 genes are based on the transcriptional profiling work of ... Interferon regulatory factor 7. IRF7. 36412_s_at. 2.1. Signal transducer and activator of transcription 2, 113 kDa. STAT2. ... Vascular endothelial growth factor. VEGF. 36101_s_at. −2.5. Transforming growth factor, beta-induced, 68 kDa. TGFBI. 1385_at. − ... XIAP associated factor-1. HSXIAPAF1. 35583_at. 3.4. Tumor necrosis factor receptor superfamily, member 6. TNFRSF6. 1440_s_at. ...http://www.jimmunol.org/content/181/1/698/tab-figures-data
Is an anticancer drug helping cancer to spread?
Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock ... Role of activating transcription factor 3 on TAp73 stability and apoptosis in paclitaxel-treated cervical cancer cells. Mol ... The activating transcription factor 3 protein suppresses the oncogenic function of mutant p53 proteins. J Biol Chem 2014; 289: ... 2) the stress response mediator (SRM) activating transcription factor 3 (ATF3) when active in non-malignant host cells is in ...https://www.medicalnewstoday.com/articles/318846.php?sr