*  2002 - Review: Metformin does not increase fatal or nonfatal lactic acidosis or blood lactate levels in type 2...
... at higher-than-average risk for lactic acidosis. Salpeter and colleagues hoped to compare the incidence of lactic acidosis in ... 3. Brown JB, Pedula K, Barzilay J, Herson MK, Latare P. Lactic acidosis rates in type 2 diabetes. Diabetes Care. 1998;21:1659- ... Review: Metformin does not increase fatal or nonfatal lactic acidosis or blood lactate levels in type 2 diabetes mellitus PDF. ... Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 ...
  http://acpjc.org/Content/137/3/issue/ACPJC-2002-137-3-088.htm
*  Metformin (Oral Route) Before Using - Mayo Clinic
Under certain conditions, too much metformin can cause lactic acidosis. The symptoms of lactic acidosis are severe and quick to ... Symptoms of lactic acidosis include abdominal or stomach discomfort, decreased appetite; diarrhea; fast or shallow breathing; a ... Shock (low blood pressure, blood circulation is poor)-A rare condition called lactic acidosis can occur. Talk with your doctor ... If symptoms of lactic acidosis occur, you should get immediate emergency medical help. ...
  https://www.mayoclinic.org/drugs-supplements/metformin-oral-route/before-using/DRG-20067074?p=1
*  Antisense oligonucleotide corrects splice abnormality in hereditary myopathy with lactic acidosis. - Physiology, Anatomy and...
... lactic acidosis, dyspnoea, palpitations, and rhabdomyolysis which can be fatal. The disease is recessively inherited and caused ... Hereditary myopathy with lactic acidosis (HML) (OMIM #255125) presents in childhood with exercise intolerance and muscle pain ... Antisense oligonucleotide corrects splice abnormality in hereditary myopathy with lactic acidosis. Sanaker PS., Toompuu M., ... Hereditary myopathy with lactic acidosis (HML) (OMIM #255125) presents in childhood with exercise intolerance and muscle pain ...
  https://www.dpag.ox.ac.uk/publications/271632
*  Lactic Acidosis Secondary to Pernicious Anemia | Annals of Internal Medicine | American College of Physicians
The first reported case of lactic acidosis secondary to severe anemia with complete and immediate reversal of the acidosis ... Lactic Acidosis and Hepatic Steatosis Associated with Use of Stavudine: Report of Four Cases Annals of Internal Medicine; 133 ( ... Review: Metformin does not increase risk for lactic acidosis in type 2 diabetes Annals of Internal Medicine; 153 (2): JC1-9 ... Review: Metformin does not increase risk for lactic acidosis in type 2 diabetes Annals of Internal Medicine; 153 (2): JC1-9 ...
  http://annals.org/aim/article-abstract/682900/lactic-acidosis-secondary-pernicious-anemia
*  Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia | Diabetes Care
Lactic acidosis. We identified 14 patients with a recorded code for lactic acidosis. After manual review of the medical records ... "metformin-associated lactic acidosis" describes a temporal relationship of metformin use and the occurrence of lactic acidosis ... acute or chronic comorbidities predisposing to lactic acidosis. These data suggest that lactic acidosis may be coincidental ... which is associated with impaired clearance of lactic acid and thereby predisposes to lactic acidosis. One case subject was ...
  http://care.diabetesjournals.org/content/31/11/2086
*  Lactate Metabolism Study in HIV Infected Persons - Full Text View - ClinicalTrials.gov
Although acidosis is rare, hyperlactatemia is common and may have long term consequences yet to be recognized. Lactic acidosis ... Acidosis. Acidosis, Lactic. Lentivirus Infections. Retroviridae Infections. RNA Virus Infections. Virus Diseases. Sexually ... HIV Infections AIDS Lactic Acidosis Lipodystrophy Drug: cofactor supplementation (thiamine, riboflavin, L-carnitine) Phase 4 ... While more rare, lactic acidosis may present also, and is associated with mortality. The consequences of chronic ...
  https://clinicaltrials.gov/show/NCT00202228
*  NATAP - Report on Lactic Acidosis and other Mitochondrial Toxicity Issues
... a history of severe lactic acidosis or manifest lactic acidosis shortly following the study.. Several studies on the effect of ... Report on Lactic Acidosis and other Mitochondrial Toxicity Issues Written for NATAP by Cecilia Shikuma, MD, the University of ... The jury is still out on whether such individuals are at risk of developing fulminant lactic acidosis syndrome. The majority of ... Finally, the possible role of intercurrent illness in the pathogenesis of lactic acidosis clearly needs to be studied as such ...
  http://www.natap.org/lipod/day8.htm
*  Metformin and Lactic Acidosis
... lactic acidosis. This page describes some of the symptoms of lactic acidosis and lists some of the factors that can increase ... Metformin and Lactic Acidosis. There are some potential adverse side effects of metformin; lactic acidosis can be one of them. ... Lactic acidosis is a very dangerous condition and is fatal in about 50 percent of cases. Risk factors for lactic acidosis when ... Understanding Lactic Acidosis. Lactic acidosis is a life-threatening condition caused by too much lactate in the blood and low ...
  http://diabetes.emedtv.com/metformin/metformin-and-lactic-acidosis.html
*  Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia | BMC Medicine |...
... had severe lactic acidosis (≥5 mmol/L). Twenty percent of participants had sickle cell anemia (HbSS), an observation consistent ... had respiratory distress and/or severe lactic acidosis, respectively. Seven (4%) children died before 28 days following ...
  https://bmcmedicine.biomedcentral.com/articles/10.1186/1741-7015-12-67
*  How does lactic acidosis affect diabetes? | Reference.com
Lactic acidosis can cause potentially fatal symptoms of metabolic acidosis, a dangerous condition that diabetics with poorly ... Whether caused by low blood sugar levels or medication, lactic acidosis in diabetics is life-threatening. Both lactic acidosis ... This is called lactic acidosis.. Diabetics are especially prone to another subtype of metabolic acidosis, called diabetic ... Lactic acidosis can cause potentially fatal symptoms of metabolic acidosis, a dangerous condition that diabetics with poorly ...
  https://www.reference.com/health/lactic-acidosis-affect-diabetes-3ee92c2f9edb59fc
*  Saxagliptin And Metformin (Oral Route) Proper Use - Mayo Clinic
Under certain conditions, too much metformin can cause a condition called lactic acidosis. The symptoms of lactic acidosis are ... Symptoms of lactic acidosis include abdominal or stomach discomfort, decreased appetite, diarrhea, fast or shallow breathing, a ... If symptoms of lactic acidosis occur, you should get immediate emergency medical help. ...
  https://www.mayoclinic.org/drugs-supplements/saxagliptin-and-metformin-oral-route/proper-use/DRG-20074625?p=1
*  Pioglitazone And Metformin (Oral Route) Before Using - Mayo Clinic
The symptoms of lactic acidosis are severe and appear quickly. Lactic acidosis usually occurs when other serious health ... The symptoms of lactic acidosis include: abdominal or stomach discomfort; decreased appetite; diarrhea; fast or shallow ... Under certain conditions, too much metformin can cause a serious condition called lactic acidosis. ...
  https://www.mayoclinic.org/drugs-supplements/pioglitazone-and-metformin-oral-route/before-using/drg-20063126?p=1
*  Metformin and Fatal Lactic Acidosis
Lactic acidosis is an uncommon but potentially fatal adverse effect. The reported frequency of lactic acidosis is 0.06 per 1000 ... Biguanide-associated lactic acidosis. Arch Intern Med 1992;152:2333-6. *Gowardman JR, Havill J. Fatal metformin induced lactic ... Doctors should suspect lactic acidosis in patients presenting with acidosis, but without evidence of hypoperfusion or hypoxia. ... Post-surgical lactic acidosis caused the death of a 70-year-old man whose metformin was not withdrawn at the time of surgery. ...
  http://www.medsafe.govt.nz/profs/PUarticles/5.htm
*  Phenformin and lactic acidosis. | The BMJ
... which supported a multifactorial aetiology for lactic acidosis. Advanced age and cardiovascular and renal disease are absolute ... Phenformin and lactic acidosis.. Br Med J 1976; 1 doi: https://doi.org/10.1136/bmj.1.6001.70 (Published 10 January 1976) Cite ... patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen ...
  http://www.bmj.com/content/1/6001/70
*  Lactic acidosis - Wikipedia
In type B lactic acidosis produced by medication, withdrawal of the medication may be necessary to resolve the lactic acidosis ... "Phenformin-Induced Lactic Acidosis in an Older Diabetic Patient: A recurrent drama (phenformin and lactic acidosis)". Diabetes ... are naturally prone to lactic acidosis.[citation needed] Lactic acidosis is also a consequence of the processes causing rigor ... The excess hydrogen cations produced during lactic acidosis are widely believed to actually derive from production of lactic ...
  https://en.wikipedia.org/wiki/Lactic_acidosis
*  Congenital lactic acidosis - Wikipedia
Congenital lactic acidosis can be caused by mutations on the X chromosome or in mitochondrial DNA. Congenital lactic acidosis ... Congenital lactic acidosis (CLA) is a rare disease caused by mutations in mitochondrial DNA (mtDNA) that affect the ability of ... Though lactic acidosis can be a complication of other congenital diseases, when it occurs in isolation it is typically caused ... There is no proven treatment for congenital lactic acidosis. Treatments that are occasionally used or that are under ...
  https://en.wikipedia.org/wiki/Congenital_lactic_acidosis
*  Lactic acidosis, prostaglandin E1, and colchicine. | The BMJ
Lactic acidosis, prostaglandin E1, and colchicine. Br Med J 1978; 1 :651 ... Lactic acidosis, prostaglandin E1, and colchicine.. Br Med J 1978; 1 doi: https://doi.org/10.1136/bmj.1.6113.651-a (Published ...
  http://www.bmj.com/content/1/6113/651.2
*  Lactic acidosis - ONA
Rapidly clearing lactic acidosis may have been the result of a seizure or occult hypoglycemia. For persistent lactic acidosis ... Prognosis of lactic acidosis depends on the etiology, duration and resolution of lactic acidosis. The underlying health state ... Good review of pathophysiology of lactic acidosis.) Grunert, S, Schmidts, M, Kenzel, S. "D-lactic acidosis: 'right-left ... The clinical features of lactic acidosis are similar to other forms of metabolic acidoses. These may include respiratory ...
  http://www.oncologynurseadvisor.com/critical-care-medicine/lactic-acidosis/article/586232/
*  Incidence of lactic acidosis in metformin users. | Diabetes Care
It is similar to previously published rates based on passive reporting of cases, and it is well below the lactic acidosis rate ... In both cases, other factors besides metformin could have contributed to the lactic acidosis. No additional cases were found on ... OBJECTIVE: The purpose of this study was to determine the incidence of lactic acidosis in a geographically defined population ... CONCLUSIONS: From 1980 through 1995, the incidence rate of lactic acidosis was 9 per 100,000 person-years (95% CI 0-21) in ...
  http://care.diabetesjournals.org/content/22/6/925
*  Congenital Lactic Acidosis - NORD (National Organization for Rare Disorders)
Congenital lactic acidosis is a rare form of lactic acidosis. The word "congenital" means that the underlying condition that ... Congenital lactic acidosis affects males and females in equal numbers. The exact incidence of congenital lactic acidosis is ... increases risk of developing lactic acidosis is present at birth. In most cases, the cause of congenital lactic acidosis is due ... Lactic acidosis can have many different causes and is often present in severely ill patients hospitalized in intensive care ...
  https://rarediseases.org/rare-diseases/congenital-lactic-acidosis/
*  MALA: Metformin-Associated Lactic Acidosis | California Poison Control System | UCSF
Lactic acidosis is typically defined as a pH less than 7.35 and blood lactate = 5 mmol/L. Severe lactic acidosis is certainly ... Acidosis and lactic acid levels cleared over the next 24 hours and creatinine levels remained normal. She was discharged on ... MALA is extremely rare when prescribed to a low-risk groups less inclined to develop lactic acidosis and avoided in those with ... The role of metformin in the development of lactic acidosis had not been completely elucidated and is further complicated in ...
  https://calpoison.org/news/mala-metformin-associated-lactic-acidosis
*  Canary Database: Browse by Outcome: Acidosis, Lactic
Browse by Outcome: Acidosis, Lactic (1 article). % of records by year: 1965 2017 ...
  http://canarydatabase.org/browse/outcome/1125
*  adefovir | Cigna
Early symptoms of lactic acidosis may get worse over time and this condition can be fatal. Get emergency medical help if you ... Some people taking adefovir develop a serious condition called lactic acidosis. This may be more likely in women, in people who ... This medicine may cause a serious condition called lactic acidosis. Get emergency medical help if you have even mild symptoms ...
  https://www.cigna.com/healthwellness/hw/medications/adefovir-d04814a1
*  Videx EC Side Effects in Detail - Drugs.com
Hyperlactatemia appeared to be more common with this drug while lactic acidosis was an infrequent occurrence.. Lactic acidosis ... Lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) have been reported with the use of nucleoside ... Fatal lactic acidosis has been reported in pregnant women who received this drug plus stavudine with other antiretroviral ... "Risk factors for lactic acidosis and severe hyperlactataemia in HIV-1-infected adults exposed to antiretroviral therapy." AIDS ...
  https://www.drugs.com/sfx/videx-ec-side-effects.html
*  Patent US6122536 - Implantable sensor and system for measurement and control of blood ... - Google Patents
These individuals are ketosis prone and may develop a severe metabolic acidosis. Wide swings in blood glucose commonly occur ... alternative metabolic pathways will dominate causing lactic acid to accumulate. Anaerobic metabolism produces an insufficient ... Those with diabetes are also prone to ketosis, and develop dehydration, acidosis, and electrolyte imbalance under stress. In ... Hypoxemia and metabolic acidosis proceeds organ failure followed by death of the mammal. ...
  http://www.google.com.au/patents/US6122536