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*  Acetoacetyl-CoA thiolase | definition of acetoacetyl-CoA thiolase by Medical dictionary
Looking for online definition of acetoacetyl-CoA thiolase in the Medical Dictionary? acetoacetyl-CoA thiolase explanation free. What is acetoacetyl-CoA thiolase? Meaning of acetoacetyl-CoA thiolase medical term. What does acetoacetyl-CoA thiolase mean?
  https://medical-dictionary.thefreedictionary.com/acetoacetyl-CoA+thiolase
*  3-ketoacyl-CoA thiolase | definition of 3-ketoacyl-CoA thiolase by Medical dictionary
Looking for online definition of 3-ketoacyl-CoA thiolase in the Medical Dictionary? 3-ketoacyl-CoA thiolase explanation free. What is 3-ketoacyl-CoA thiolase? Meaning of 3-ketoacyl-CoA thiolase medical term. What does 3-ketoacyl-CoA thiolase mean?
  http://medical-dictionary.thefreedictionary.com/3-ketoacyl-CoA+thiolase
*  Beta ketothiolase deficiency
... or 2M3HBA is a rare genetic condition. 2M3HBA results from a mutation (error) in a person's DNA. 2M3HBA is considered an organic acid condition because it leads to a buildup of harmful amounts of organic acids in the body. Protein in the food we eat is broken down into amino acids, or "building blocks". We typically eat more protein than needed; therefore we often have more amino acids than we need. Enzymes (special proteins) breakdown the extra amino acids into organic acids and ammonia, and then harmless products our body can get rid of. If one of the enzymes needed is missing or not working correctly, the amino acid is not broken all the way down and builds up in our system as organic acids. Although organic acids are only mild acids, both organic acids and ammonia can damage our bodies if too much builds up. In this case the enzyme, 2-methyl-3-hydroxybutyryl, is unable to break down the amino acid, isoleucine.. Signs of 2M3HBA typically begin to show during ...
  http://diseaseinfosearch.org/Beta+ketothiolase+deficiency/812
*  Partial purification and characterization of 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase from rat...
The enzyme 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine: acetyl-CoA acetyltransferase (EC 2.3.1.67) was purified from rat spleen approx. 1500-fold in 1.6% yield. The specific activity of the purified enzyme was 0.317 +/- 0.089 mumol/min per mg of protein (mean +/- S.D., n = 6). The Km for the substrate acetyl-CoA was 137 +/- 13 microM and the pH optimum was about 8. Incubation of the purified enzyme was 1-O-[3H]octadecyl-2-lyso-sn-glycero-3-phosphocholine followed by electrophoresis resulted in the incorporation of radioactivity into a protein of Mr 29,000. The enzyme was most active towards 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine as substrate, 1-palmitoyl-2-lyso-glycero-3-phosphocholine being a poor substrate. In addition, the enzyme preferred acetyl-CoA to palmitoyl-CoA or oleoyl-CoA as substrate.. ...
  http://www.biochemj.org/content/237/2/439
*  2ib7 - Proteopedia, life in 3D
Thiolases are CoA-dependent enzymes which catalyze the formation of a carbon-carbon bond in a Claisen condensation step and its reverse reaction via a thiolytic degradation mechanism. Mitochondrial acetoacetyl-coenzyme A (CoA) thiolase (T2) is important in the pathways for the synthesis and degradation of ketone bodies as well as for the degradation of 2-methylacetoacetyl-CoA. Human T2 deficiency has been identified in more than 60 patients. A unique property of T2 is its activation by potassium ions. High-resolution human T2 crystal structures are reported for the apo form and the CoA complex, with and without a bound potassium ion. The potassium ion is bound near the CoA binding site and the catalytic site. Binding of the potassium ion at this low-affinity binding site causes the rigidification of a CoA binding loop and an active site loop. Unexpectedly, a high-affinity ...
  http://proteopedia.org/wiki/index.php/2ib7
*  phaA - Acetyl-CoA acetyltransferase - Zoogloea ramigera - phaA gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
  http://www.uniprot.org/uniprot/P07097
*  Lirias: Isolation and subunit composition of native sterol carrier protein 2/3-oxoacyl-coenzyme a thiolase from normal rat...
In the present report we describe a method for the complete purification of native sterol carrier protein 2/3-oxoacyl-CoA thiolase (SCP-2/thiolase) from normal rat liver peroxisomes. The isolation procedure is based on the alteration in chromatographic properties of the enzyme in the presence of low concentrations of CoA. The purified preparation of SCP-2/thiolase consisted of 58- and 46-kDa polypeptides. Peroxisomes prepared freshly from normal rat liver contained three SCP-2/thiolase isoforms, separable by conventional chromatography. Immunochemical, molecular sieving, and chemical cross-linking experiments indicated that these isoforms represent thiolytically active homo- and heterodimeric combinations of the 46- and 58-kDa subunits (2 x 58, 58-46, and 2 x 46-kDa proteins). (C) 2000 Academic Press ...
  https://lirias.kuleuven.be/handle/123456789/207492
*  acetoacetyl coenzyme A thiolase | definition of -acetoacetyl coenzyme A thiolase by Medical dictionary
Looking for online definition of -acetoacetyl coenzyme A thiolase in the Medical Dictionary? -acetoacetyl coenzyme A thiolase explanation free. What is -acetoacetyl coenzyme A thiolase? Meaning of -acetoacetyl coenzyme A thiolase medical term. What does -acetoacetyl coenzyme A thiolase mean?
  http://medical-dictionary.thefreedictionary.com/-acetoacetyl+coenzyme+A+thiolase
*  Formate C-acetyltransferase - Wikipedia
In enzymology, formate C-acetyltransferase (pyruvate formate lyase, PFL) (EC 2.3.1.54) is an enzyme. Pyruvate formate lyase is found in Escherichia coli and other organisms. It helps regulate anaerobic glucose metabolism. Using radical non-redox chemistry, it catalyzes the reversible conversion of pyruvate and coenzyme-A into formate and acetyl-CoA. The reaction occurs as follows: This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:formate C-acetyltransferase. Other names in common use include pyruvate formate-lyase, pyruvic formate-lyase, and formate acetyltransferase. This enzyme participates in 3 metabolic pathways: pyruvate metabolism, propanoate metabolism, and butanoate metabolism. As of late 2007, 8 structures have been solved for this class of ...
  https://en.wikipedia.org/wiki/Formate_C-acetyltransferase
*  RCSB PDB - 1M1O: Crystal structure of biosynthetic thiolase, C89A mutant, complexed with acetoacetyl-CoA Literature...
1M1O: The catalytic cycle of biosynthetic thiolase: A conformational journey of an acetyl group through four binding modes and two oxyanion holes
  http://www.rcsb.org/pdb/explore/litView.do?structureId=1M1O
*  Sterol carrier protein 2 Proteins: Novus Biologicals
Sterol carrier protein 2 Proteins available through Novus Biologicals. Browse our Sterol carrier protein 2 Protein catalog backed by our Guarantee+.
  https://www.novusbio.com/proteins/sterol-carrier-protein-2?related_pathways=Intracellular%20Transport
*  UniProtKB/SwissProt variant VAR 007499
3-ketothiolase deficiency (3KTD) [MIM:203750]: An inborn error of isoleucine catabolism characterized by intermittent ketoacidotic attacks associated with unconsciousness. Some patients die during an attack or are mentally retarded. Urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, triglylglycine, butanone is increased. It seems likely that the severity of this disease correlates better with the environmental or acquired factors than with the ACAT1 genotype. {ECO:0000269,PubMed:1346617, ECO:0000269,PubMed:1715688, ECO:0000269,PubMed:7728148, ECO:0000269,PubMed:9744475}. Note=The disease is caused by mutations affecting the gene represented in this entry ...
  http://web.expasy.org/variant_pages/VAR_007499.html
*  PEX7 - Peroxisomal targeting signal 2 receptor - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - PEX7...
Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import essential for import of 3-oxoacyl-CoA thiolase (a PTS2-containing protein) into peroxisomes. May direct thiolase to peroxisomes by shuttling between the cytosol and peroxisomal membranes.
  http://www.uniprot.org/uniprot/P39108
*  ACAT1 Gene - GeneCards | THIL Protein | THIL Antibody
Complete information for ACAT1 gene (Protein Coding), Acetyl-CoA Acetyltransferase 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACAT1
*  fadI - 3-ketoacyl-CoA thiolase - Escherichia coli O139:H28 (strain E24377A / ETEC) - fadI gene & protein
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
  http://www.uniprot.org/uniprot/A7ZPF9
*  fadA - 3-ketoacyl-CoA thiolase - Escherichia coli O9:H4 (strain HS) - fadA gene & protein
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
  http://www.uniprot.org/uniprot/A8A6V0
*  AACS - Acetoacetyl-CoA synthetase - Gallus gallus (Chicken) - AACS gene & protein
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).
  http://www.uniprot.org/uniprot/Q5ZLG0
*  Aacs - Acetoacetyl-CoA synthetase - Mus musculus (Mouse) - Aacs gene & protein
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).
  http://www.uniprot.org/uniprot/Q9D2R0
*  Das aktive Zentrum der Thiolase blockieren | EurekAlert! Science News
Wissenschaftler der finnischen Universität Oulu und des Helmholtz-Zentrum Berlin haben neue Wege zur Medikamentenentwicklung gegen die afrikanische Schlafkrankheit und andere von Parasiten übertragene, tropische Erkrankungen aufgezeigt. Grundlage dafür sind Strukturuntersuchungen an einem als Thiolase bezeichneten Enzym. Thiolase spielt eine wichtige Rolle im Lipid-Stoffwechsel krankheitsübertragender Parasiten. Die Struktur des Biomoleküls haben die Forscher an der MX-Beamline des Elektronenspeicherrings BESSY II des HZB untersucht.
  https://www.eurekalert.org/pub_releases_ml/2013-11/aaft-daz110713.php
*  Role of the Sterol Carrier Protein-2 N-Terminal Membrane Binding Domain in Sterol Transfer †
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  https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi0260536
*  WikiGenes - SCP2 - sterol carrier protein 2
The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
  https://www.wikigenes.org/e/gene/e/6342.html
*  acetoacetyl-CoA (CHEBI:15345)
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds.
  https://www.ebi.ac.uk/chebi/searchId.do?chebiId=15345
*  Human Metabolome Database: Showing metabocard for Acetoacetyl-CoA (HMDB0001484)
InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t14-,18-,19-,20?,24-/m1/ ...
  http://www.hmdb.ca/metabolites/HMDB0001484
*  SCP2 Gene - GeneCards | NLTP Protein | NLTP Antibody
Complete information for SCP2 gene (Protein Coding), Sterol Carrier Protein 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SCP2
*  Yagyu Hiroaki | TRIOS
マクロファージのアシルC0A:コレステロールアシルトランスフェラーゼ1 (ACAT1)欠損マウスの皮膚黄色腫、動脈硬化病変形成におけるインフラマソームの役割についての検討 ...
  http://trios.tsukuba.ac.jp/en/researcher/0000003427