The A-kinase anchoring proteins or A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have ... Marin, Wenwen (January 2020). "A-kinase anchoring protein 1 (AKAP1) and its role in some cardiovascular diseases". Journal of ... Articles with short description, Short description matches Wikidata, A-kinase-anchoring proteins). ... AKAPs act as scaffold proteins wherein they bind PKA and other signaling proteins and physically tether these multi-protein ...

... a member of the A Kinase Anchor Protein (AKAP) family of polypeptides that bind the regulatory (RII) subunit of protein kinase ... a member of the A Kinase Anchor Protein (AKAP) family of polypeptides that bind the regulatory (RII) subunit of protein kinase ... a member of the A Kinase Anchor Protein (AKAP) family of polypeptides that bind the regulatory (RII) subunit of protein kinase ... a member of the A Kinase Anchor Protein (AKAP) family of polypeptides that bind the regulatory (RII) subunit of protein kinase ...

Knockout of A-kinase anchoring protein GSKIP in mice causes perinatal lethality. Title: Knockout of A-kinase anchoring protein ... A-kinase anchoring proteins (AKAPs) control the localization of cAMP-dependent protein kinase A (PKA) and tether PKA to ... Knockout of A-kinase anchoring protein GSKIP in mice causes perinatal lethality. *Login ... AKAPs engage in protein-protein interactions with PKA substrates and other signalling proteins and form multi-protein complexes ...

located_in anchoring junction IEA Inferred from Electronic Annotation. more info. located_in axon ISO Inferred from Sequence ... MAP kinase 1. MAP kinase 2. MAPK 1. MAPK 2. extracellular signal-regulated kinase 2. mitogen-activated protein kinase 2. p42- ... enables mitogen-activated protein kinase kinase kinase binding ISO Inferred from Sequence Orthology. more info ... Mapk1 mitogen-activated protein kinase 1 [Mus musculus] Mapk1 mitogen-activated protein kinase 1 [Mus musculus]. Gene ID:26413 ...

Efficient phosphorylation requires that PKA be anchored close to its targets by A-kinase anchoring proteins (AKAPs). Cardiac ... As MMGL has previously been shown to interact with phosphodiesterase 4D, we speculated that it may be a PKA-anchoring protein ( ... the ability of MMGL isoform 4 to interact with PKA regulatory subunits R1A and R2A using Y2H-based direct protein-protein ... causing sarcomeric proteins which regulate contractility in response to PKA phosphorylation. During a yeast 2-hybrid (Y2H) ...

1998) The A kinase anchoring protein is required for mediating the effect of protein kinase A on ROMK1 channels. Proc Natl Acad ... 1999) The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels ... 1997a) D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci USA 94:11184-11189. ... 1997b) Identification of a novel protein kinase A anchoring protein that binds both type I, type II regulatory subunits. J Biol ...

... protein kinase C epsilon phosphorylation sites in P; CK II, casein kinase phosphorylation sites in P; SIG, signal peptide; ... Furin, furin cleavage site; TM, transmembrane anchor of G; A - D, conserved RNA-dependent RNA polymerase motifs. Conserved ... N, nucleoprotein; P, phosphoprotein; X, X protein; M, matrix protein; G, glycoprotein; L, L-polymerase protein. Genome regions ... Conservation of genome organization, regulatory sequences, and protein domains of Borna disease virus (BDV) in novel strains ...

The A-kinase anchoring protein 79/150 (AKAP79/150) signaling scaffold regulates AMPAR phosphorylation, channel activity, and ... Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. ...

A-kinase anchoring protein 95 (AKAP95). ENSAMEP00000000344. PF07535. 0.00033. zf-DBF. DBF zinc finger. ... Protein. Program. Term. IPRS. Start. End. Score. Description. ENSAMEP00000000344. ProSitePatterns. PS00028. IPR007087. 159. 181 ...

... which are often spatially compartmentalized by anchoring proteins to increase signalling specificity1. These scaffold proteins ... stimulation of β-adrenergic receptors increases cyclic AMP levels and activates protein kinase A (PKA)5, which stimulates ... measured this using an improved fluorescent reporter and by phosphorylation of endogenous cAMP-response-element binding protein ... Hormones mobilize intracellular second messengers and initiate signalling cascades involving protein kinases and phosphatases, ...

A-kinase anchor protein 12 (AKAP12; also known as Gravin) functions as a tumor suppressor in several human primary cancers. ... protein binding - protein deacetylase activity - protein deacetylation - regulation of mitotic cell cycle - regulation of ... Finally, a protein-protein interaction (PPI) network was constructed, as well as functional annotation and pathway enrichment ... C-terminal binding protein (CtBP) interacting protein (CtIP). These SFN analogs also altered HAT/HDAC activities and histone ...

A-kinase anchoring protein 9. ISO. RGD. PMID:18772391. RGD:2313147. NCBI chr 7:83,942,590...84,108,648 Ensembl chr 7:97,540,356 ... A-kinase anchoring protein 5. ISO. RGD. PMID:20410303. RGD:7242424. NCBI chr14:45,045,476...45,050,946 Ensembl chr14:63,302,200 ... A-kinase anchoring protein 6. ISO. RGD. PMID:19574217. RGD:6902943. NCBI chr14:12,978,221...13,602,732 Ensembl chr14:31,395,026 ... A-kinase anchoring protein 5. ISO. RGD. PMID:20410303. RGD:7242424. NCBI chr14:45,045,476...45,050,946 Ensembl chr14:63,302,200 ...

Name: A kinase anchor protein 13. Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik ...

... protein was found downregulated across the grades. AKAP12 knockdown in benign meningioma cells SF4433 increases proliferation, ... In the discovery set of fresh-frozen tissue specimens (14), the A-kinase anchor protein 12 (AKAP12) ... In the discovery set of fresh-frozen tissue specimens (14), the A-kinase anchor protein 12 (AKAP12) protein was found ... Down-Regulation of Tumor Suppressor A Kinase Anchor Protein 12 in Human Hepatocarcinogenesis by Epigenetic Mechanisms. ...

Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Mol Endocrinol ... Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J Biol Chem. 1997 Feb 21;272(8):4747-52.[PubMed] ... protein 14-3-3 and a protein kinase, glycogen synthase kinase 3 (GSK-3). ... Subcellular localization of the regulatory subunits of cyclic adenosine 3,5-monophosphate-dependent protein kinase in bovine ...

Gpr161 is an A-kinase anchoring protein and the cAMP-sensing Gpr161:PKA complex acts as cilium-compartmentalized signalosome ... General protein information Go to the top of the page Help Preferred Names. G-protein coupled receptor 161. Names. G-protein ... The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in ... mRNA and Protein(s) * NM_001267609.1 → NP_001254538.1 G-protein coupled receptor 161 isoform 1 ...

... nuclear proteins, chaperones, Alzheimer disease-related proteins, oxidative stress proteins, kinases, and neuronal proteins. [ ... Myotilin protein binds to α-actinin, filamin C, and actin, and it is likely important in stabilizing and anchoring thin ... Telethonin protein (titin-cap protein) is a sarcomeric protein present in the Z disk that binds to titin and several other Z- ... Dysferlin protein is a large membrane protein with sequence analogy to the nematode protein fer-1, and is a member of the ...

AKAP, A-kinase anchoring proteins; ATF, activating transcription factor; BAPTA, bis(2-aminophenoxy)ethane-N,N,N′,N′- ... Lester LB, Langeberg LK, Scott JD: Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc Natl Acad ... Thorens B, Deriaz N, Bosco D, DeVos A, Pipeleers D, Schuit F, Meda P, Porret A: Protein kinase A-dependent phosphorylation of ... The response to GLP-1 was mimicked by forskolin and largely inhibited by the protein kinase A (PKA) inhibitors, H89 and ...

A kinase (PRKA) anchor protein 7. ALDH8A1. 64577. 6q23.2. 135238528. 135271260. 32732. REVIEWED. aldehyde dehydrogenase 8 ... mitogen-activated protein kinase kinase kinase 5. MAP7. 9053. 6q23.3. 136663872. 136871792. 207920. REVIEWED. microtubule- ... ribosomal protein L15 pseudogene 9. RPL17P23. 100271152. 6q22.33. 127756759. 127757360. 601. INFERRED. ribosomal protein L17 ... ribosomal protein L21 pseudogene 64. RPL21P66. 100271179. 6q23. 132839950. 132840470. 520. INFERRED. ribosomal protein L21 ...

Jones, R.G.; Plas, D.R.; Kubek, S.; Buzzai, M.; Mu, J.; Xu, Y.; Birnbaum, M.J.; Thompson, C.B. AMP-activated protein kinase ... Li, S.; Couet, J.; Lisanti, M.P. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding ... Such prenylation has important roles in the generation of lipidated protein domains that enable protein-protein interactions ... Hardie, D.G. The AMP-activated protein kinase pathway-New players upstream and downstream. J. Cell Sci. 2004, 117, 5479-5487. [ ...

Protein-Protein Interactions as New Drug Targets - Author: Klussmann, Enno - Price: 339,90€ ... 1. A-Kinase Anchoring Proteins as the Basis for cAMP Signaling. K. L. Dodge-Kafka, A. Bauman, M. S. Kapiloff. 2. Arrestins as ... Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept. 16. Domains Mediate Protein-Protein ... 8. Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug ...

... and discuss how this molecule infl uences the retention and clustering of diverse synaptic proteins to regulate synaptic ... and discuss how this molecule influences the retention and clustering of diverse synaptic proteins to regulate synaptic ... Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins: ... localization regulated by NMDA receptor activation through translocation of an A-kinase anchoring protein scaffold protein. J. ...

Mechanisms of protein kinase A anchoring. References Authors * Skroblin P Show Other ...

A Kinase Anchor Proteins:physiology, Animals, Humans, Signal Transduction:physiology,. Citation OBJECTIVE: Kinase Anchoring ... Proteins (AKAPs) have evolved to regulate the spatial and temporal organization of cellular signal transductio..... ...

A Kinase Anchor Proteins:physiology, Animals, Humans, Signal Transduction:physiology,. Citation OBJECTIVE: Kinase Anchoring ... Protein Processing, Post-Translational:physiology, RNA, Messenger:genetics, RNA, Small Interfering:genetics,. Citation ... Proteins (AKAPs) have evolved to regulate the spatial and temporal organization of cellular signal transductio..... ...

... binds the glycosylphosphatidylinositol-anchored protein GFRα3 and the receptor tyrosine kinase Ret. Expression of the GFRα3 ... Artemin activates src-family kinase-dependent cell-signaling pathways after binding to its GFRα3 and Ret kinase receptor ... activate the Ret receptor tyrosine kinase through binding of glycosylphosphatidylinositol-anchored GDNF family receptor α ... The TRPA1 channel protein is a marker for GFRα3 neurons and is modulated by artemin level. In addition to TRPV1, increased skin ...

Calcium-dependent protein kinases (CDPKs) have been shown to play important roles in various physiological processes, including ... These 40 maize CDPKs have been grouped based on their phylogenetic relationships and are anchored to specific chromosomes. The ... Calcium signaling through protein kinases The Arabidopsis calcium-dependent protein kinase gene family. Plant Physiol. 2002, ... The CDPK are one of the well-known Ca2+-sensor protein kinases involved in environmental stress resistance, and these kinases ...

... and regulation of ryanodine receptors and A-kinase anchoring proteins. We initially identified vertebrate Clic4 as a candidate ... CLIC proteins might have several biochemical functions including intracellular chloride channel activity, modulation of ...

Poppinga WJ, Munoz-Llancao P, Gonzalez-Billault C, Schmidt M: A-kinase anchoring proteins: cAMP compartmentalization in ... AKAP7 encodes protein family binding to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA); sElevation of cAMP ... For instance, ATF7IP can form a protein-complex by binding to MBD1 (methyl CpG binding protein 1) and Aire (autoimmune ... ATF7IP can interact with methyl CpG binding protein 1 (MBD1) and the autoimmune regulator (Aire) protein to maintain immune ...