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*  CYCLIC AMP PHOSPHODIESTERASE 4D7 ISOFORMS AND METHODS OF USE - Memory Pharmaceuticals Corporation
... rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are ... "Cloning and Expression of cDNA for a human low KM rolipram sensitive cyclic AMP phosphodiesterase," Molecular and Cellular Biol ... Heterologous Expression and Purification of Recombinant Rolipram-Sensitive Cyclic AMP-Specific Phosphodiesterases, in Methods: ... Agents that inhibit such synthesis and/or activity (antagonists) may, e.g., result in an increased cyclic AMP level within the ...
  http://www.freepatentsonline.com/y2005/0289660.html
*  Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase...
This action can be detected by attenuating the degradation of cyclic AMP by using inhibitors of cyclic AMP phosphodiesterase. ... adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP ... adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP ... adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP ...
  http://www.biochemj.org/content/249/2/543
*  4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone (ZK 62711): a Potent Inhibitor of Adenosine Cyclic 3',5'-Monophosphate...
... inhibits soluble and particulate cyclic AMP phosphodiesterases but is less potent with respect to cyclic GMP phosphodiesterases ... increases basal levels of cyclic AMP in both cortical and cerebellar slices. Increases in intracellular levels of cyclic AMP in ... with respect to the calcium-dependent cyclic AMP phosphodiesterase, and in brain slices it is similarly 100 times more potent ... since both basal and norepinephrine-elicited accumulations of cyclic AMP are increased by ZK 62711 in the presence of exogenous ...
  http://molpharm.aspetjournals.org/content/12/6/900
*  Frontiers | The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock...
Difrancesco, D., and Tortora, P. (1991). Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature ... 2008). Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing ... Positive chronotropic responses of rabbit sino-atrial node cells to flash photolysis of caged isoproterenol and cyclic AMP. ... 3. .. 3931. ·. [. P. L. B. p. ]. 4. .. 0695. 0. .. 2805. 4. .. 0695. +. [. P. L. B. p. ]. 4. .. 0695. -. 0. .. 0952. .. (. 13. ...
  https://www.frontiersin.org/articles/10.3389/fphys.2016.00419/full
*  Antiplatelet treatment with cilostazol after stent implantation | Heart
Cilostazol inhibits the action of cyclic AMP phosphodiesterase in platelets and the production of platelet derived growth ... 10 It suppresses platelet aggregation and release reaction by increasing the concentration of cyclic AMP in platelets. It ... Objectives To evaluate the efficacy of cilostazol, a new synthetic inhibitor of phosphodiesterase, in preventing stent ... a novel potent inhibitor of phosphodiesterase, has an antiplatelet effect similar to that of ticlopidine and a lower rate of ...
  http://heart.bmj.com/content/80/4/393
*  Ryanodine receptors | Skeletal Muscle | Full Text
Ziolo MT: The fork in the nitric oxide road: cyclic GMP or nitrosylation? Nitric Oxide 2008, 18: 153-156. 10.1016/j.niox. ... Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR: Phosphodiesterase 4D ... Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J 1999, 77: 1936-1944. ... the cAMP-specific phosphodiesterase (PDE)4D3 and Ca2+/calmodulin-dependent protein kinase (CaMK)II [37, 48], emphasizing the ...
  https://skeletalmusclejournal.biomedcentral.com/articles/10.1186/2044-5040-1-18
*  Frontiers | PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis | Pharmacology
Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and ... Using phosphodiesterase type 5 (PDE5) inhibitors, we and others have provided evidence of rescued F508del-CFTR trafficking and ... Cyclic AMP-dependent Cl secretion is regulated by multiple phosphodiesterase subtypes in human colonic epithelial cells. J. ... Hamet, P., and Coquil, J. F. (1978). Cyclic GMP binding and cyclic GMP phosphodiesterase in rat platelets. J. Cyclic Nucleotide ...
  https://www.frontiersin.org/articles/10.3389/fphar.2012.00167/full
*  Gentaur Molecular :Bioassays \ pNPP Phosphatase Assay Kit \ POPN-500
... cyclic AMP phosphodiesterase) (cAMP phosphodiesterase) (EC 3.1.4.53). [EPM2A] Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48 ... cyclic phosphate phosphodiesterase (H2N-cP phosphodiesterase) (H2Neo-cP phosphodiesterase) (EC 3.1.4.56) (7,8-dihydro-D- ... cyclic phosphate phosphodiesterase). [aphA napA] Class B acid phosphatase (CBAP) (EC 3.1.3.2) (Minor phosphate-irrepressible ... cyclic-nucleotide 2'-phosphodiesterase) (EC 3.1.4.16) (Calcineurin-like phosphoesterase) (Phosphoenolpyruvate phosphatase) (EC ...
  http://www.antibody-antibodies.com/product_det.php?id=355209&supplier=search&name=pNPP%20Phosphatase%20Assay%20Kit
*  Coleus forskohlii | Wesley Medical Center
... forskolin increases the levels of a fundamental natural compound known as cyclic AMP. 1,2 Cyclic AMP plays a major role in many ... Schlepper M, Thormann J, Mitrovic V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res ... because that disease appears to be at least partly related to low levels of cyclic AMP in skin cells. ... 3 , as well as by relaxing smooth muscle tissue. 4,5 Based on these apparent effects, Coleus forskohlii has been suggested as a ...
  https://wesleymc.com/hl/?/21689/Coleus-Forskohlii
*  Caffeine Mitigates Lung Inflammation Induced by Ischemia-Reperfusion of Lower Limbs in Rats
M. Conti and J. Beavo, "Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic ... S. Gerlo, R. Kooijman, I. M. Beck, K. Kolmus, A. Spooren, and G. Haegeman, "Cyclic AMP: a selective modulator of NF-κB action ... Wei-Chi Chou,1,2 Ming-Chang Kao,1,2 Chung-Tai Yue,3 Pei-Shan Tsai,4 and Chun-Jen Huang1,2 ... 5, pp. 351-359, 1997. View at Publisher · View at Google Scholar · View at Scopus ...
  https://www.hindawi.com/journals/mi/2015/361638/ref/
*  Plus it
Type I adenylyl cyclase functions as a coincidence detector for control of cyclic AMP response element-mediated transcription: ... Barad M, Bourtchouladze R, Winder DG, Golan H, and Kandel E. Rolipram, a type IV-specific phosphodiesterase inhibitor, ... Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP. Science 265: 1878-1882, 1994. ... For example, rolipram, an older type IV phosphodiesterase inhibitor that leads to increases in cAMP, can promote memory ...
  http://physiologyonline.physiology.org/content/19/5/271
*  Plus it
1993) Calcium entry via L-type calcium channels acts as a negative regulator of adenylyl cyclase activity and cyclic AMP levels ... phosphodiesterase. EGTA. ethylene glycol bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid. HEPES. 4-(2-hydroxyethyl)-1- ... IP3. inositol triphosphate. PTX. pertussis toxin. CCK-8. cholecystokinin octapeptide. PLC. phospholipase C. [Ca2+]i. ... 1991) IP3-dependent Ca2+ mobilization in circular but not longitudinal muscle cells of intestine. Am J Physiol 261:G937-G944. ...
  http://molpharm.aspetjournals.org/content/54/1/122
*  Items where year is 1987 - Strathprints
Price, B and Pyne, N J and Houslay, M D (1987) Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be ... high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity. ... and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat. Biochemical ... 3-6. ISSN 2046-5378 Ashcroft, Brian and Love, Jim and Boyle, Stephen and Draper, Paul and Harrigan, Frank and Jenkins, Iain and ...
  https://strathprints.strath.ac.uk/view/year/1987.type.html
*  Development - Beta-adrenergic receptors regulation of ERK Pathway Map - PrimePCR | Life Science | Bio-Rad
A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nature cell biology 2001 Nov;3(11): ... beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proceedings ... A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nature cell biology 2001 Nov;3(11): ... Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/pathway/development-beta-adrenergic-receptors-regulation-erk
*  ASMscience | Introduction to Second M
Today, the mammalian cyclic AMP (cAMP) signal transduction network is known to include a dizzying array of G-protein-coupled ... cyclic diguanylic acid (also known as cyclic di-GMP [c-di-GMP]) to proteins that contained either the GGDEF domain, the EAL ... and a variety of cyclic nucleotide-gated ion channels. The parallels between the mammalian cAMP network and the bacterial ... Mehats, C.,, C. B. Andersen,, M. Filopanti,, S.-L. C. Jin, and, M. Conti. 2002. Cyclic nucleotide phosphodiesterases and their ...
  http://www.asmscience.org/content/book/10.1128/9781555816667.ch01
*  3,3- - What does 3,3- stand for? The Free Dictionary
Looking for online definition of 3,3- or what 3,3- stands for? 3,3- is listed in the World's largest and most authoritative ... cyclic nucleotide phosphodiesterase. *3',5' cyclic nucleotide phosphodiesterase 8B, hsPDE8B. *3',5'-AMP ... cyclic AMP synthetase. *3',5'-cyclic AMP synthetase. *3',5'-GMP ... 3,3- - What does 3,3- stand for? The Free Dictionary https:// ... 3,3-(2 Carboxypiperazine-4-yl)-Propyl-1-Phosphonate (NMDA receptor antagonist). ...
  https://acronyms.thefreedictionary.com/3%2C3-
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Two phosphodiesterase genes, PDEL and PDEH, regulate development and pathogenicity by modulating intracellular cyclic AMP ... Cyclic AMP (cAMP) signaling plays an important role in regulating multiple cellular responses, such as growth, morphogenesis, ... and hydrolysis by cAMP phosphodiesterases (PDEases). The rice blast fungus Magnaporthe oryzae contains a high-affinity (PdeH/ ... JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library. ...
  https://www.jove.com/visualize?author=Xiaobo%20Zheng%20
*  Table of Contents - December 01, 1985, 13 (6) | Biochemical Society Transactions
Multifunctional cyclic nucleotide phosphodiesterase activity in lettuce cotyledons D. CHIATANTE, R. P. NEWTON, E. G. BROWN ... A role for protein kinase C in cyclic AMP metabolism LAWRENCE A. QUILLIAM, PAULINE R. M. DOBSON, BARRY L. BROWN ... Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian tissues RUSSELL P. NEWTON, SA'AD G. SALIH, NABIL A. ... Partial purification of a phosphatidylinositol phosphodiesterase isolated from lymphocytes HELEN R. CARTER, ANTHONY D. SMITH ...
  http://www.biochemsoctrans.org/content/13/6
*  The Migraine-Stroke Connection
Dipyridamole, a phosphodiesterase 5 inhibitor, has been reported to induce migraine in patients with migraine without aura [121 ... Guo S, Olesen J, Ashina M. Phosphodiesterase 3 inhibitor cilostazol induces migraine-like attacks via cyclic AMP increase. ... Cilostazol, an antiplatelet drug that inhibits phosphodiesterase 3, has also vasodilatory activity. In CSPS-2 trial, 313 of ... Triptan (Selective 5-HT1B/1D agonist agent). Triptans may present with stroke-like events but there is no convincing evidence. ...
  http://j-stroke.org/journal/view.php?viewtype=pubreader&number=133
*  NAVER Academic > Search...
Cyclic-AMP Phosphodiesterases, blood, Animals, Calcium-Binding Proteins, Calmodulin, Cyclic AMP, Cytoplasm, enzymology, Enzyme ... The regulation of cyclic AMP metabolism in the rat erythrocyte has been investigated during chronic exposure to the β agonist ... Regulation of cyclic AMP metabolism in the rat erythrocyte during chronic beta-adrenergic stimulation. Evidence for calmodulin- ... Regulation of cyclic AMP metabolism in the rat erythrocyte during chronicβ-adrenergic stimulation. Evidence for calmodulin- ...
  http://academic.naver.com/search.naver?field=3&query=Journal+of+Membrane+Biology+58%EA%B6%8C+3%ED%98%B8
*  Plus it
HEPES buffer and then incubated in 500 μl/well serum-free DMEM containing the cyclic AMP phosphodiesterase inhibitor rolipram ( ... cyclic AMP were determined by liquid scintillation counting.. RT-PCR. Total RNA was extracted from cardiomyocytes treated or ... cyclic AMP-independent relaxations of guinea-pig gastrointestinal smooth muscles. Arch Pharmacol 367: 193-203. ... Cyclic AMP was isolated by sequential Dowex-alumina chromatography as described previously (Dickenson and Hill, 1998). After ...
  http://jpet.aspetjournals.org/content/316/1/392
*  Phosphodiesterase 4D, cAMP-specific | definition of phosphodiesterase 4D, cAMP-specific by Medical dictionary
... phosphodiesterase 4D, cAMP-specific explanation free. What is phosphodiesterase 4D, cAMP-specific? Meaning of phosphodiesterase ... Looking for online definition of phosphodiesterase 4D, cAMP-specific in the Medical Dictionary? ... cyclic-AMP phosphodiesterase activity and hydrolyses the second messenger cAMP to AMP, thereby playing a role in regulating ... redirected from phosphodiesterase 4D, cAMP-specific) PDE4D. A gene on chromosome 5q12 that encodes a counterpart of the fruit ...
  https://medical-dictionary.thefreedictionary.com/phosphodiesterase+4D%2C+cAMP-specific
*  Healthy Life Lessons: Fat Chance
1. increase in cyclic AMP formation through activation of proteins G. 2. maintenance of the cAMP pool by inhibition of ... UNISLIM™ also stimulates lipolysis (+170%) by inhibiting phosphodiesterase. This action is mediated by more conventional active ... 3. activation and transport of fatty acids towards the mitochondria for combustion generating ATP.. The in vitro studies have ... 3. biotechnological coenzyme A (CoA). and acts via 3 different pathways on lipolysis:. ...
  http://talesofa30somethingnothing2010.blogspot.com/2013/07/fat-chance.html
*  Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase.
We have analyzed the brain distribution of the rat cAMP-specific phosphodiesterases (rPDEIV) which are closely related to the ... Cyclic-AMP Phosphodiesterases, Animals, Base Sequence, Brain Chemistry, Cyclic AMP, Hippocampus, In Situ Hybridization, Long- ... We have analyzed the brain distribution of the rat cAMP-specific phosphodiesterases (rPDEIV) which are closely related to the ... Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase. ...
  https://oacentre.kennedy.ox.ac.uk/publications/107518
*  Plus it
In this regard, it is noteworthy that medications that increase NO signaling medications, such as the phosphodiesterase-5 (PDE5 ... AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated ... which in turn activates cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) by increasing cytoplasmic cGMP ... A: BMDMs from WT and Vasp−/− mice were stimulated with LPS (5 ng/mL) and IFN-γ (12 ng/mL) for 1 h. M1 markers, as measured by ...
  http://diabetes.diabetesjournals.org/content/64/8/2836