*  Ala(1,3,11,15)- endothelin 1 Summary Report | CureHunter
15)- endothelin 1: alanyl residues substituted for cysteinyl in endothelin-1; RN given refers to (all-L)-isomer; has been used ... Amino Acids, Peptides, and Proteins*Proteins: 90489*Intercellular Signaling Peptides and Proteins: 12097*Endothelins: 3957*Ala( ... epoxymethano)prosta-5,13-dienoic Acid CureHunter Inc. provides medical information and specifically does NOT provide medical ... Ala(1,3,11,15)- endothelin 1. Subscribe to New Research on Ala(1,3,11,15)- endothelin 1 ...
  http://www.curehunter.com/public/keywordSummaryC061779-Ala-1-3-11-15---endothelin-1.do
*  List of MeSH codes (D23) - Wikipedia
... epoxymethano)prosta-5,13-dienoic acid MeSH D23.469.050.175.725.740 --- prostaglandins a MeSH D23.469.050.175.725.750 --- ... large neutral amino acid-transporter 1 MeSH D23.050.301.264.035.246 --- antigens, cd146 MeSH D23.050.301.264.035.247 --- ... transforming growth factor alpha MeSH D23.348.479.992.720 --- transforming growth factor beta MeSH D23.348.479.996 --- wnt ... epoxymethano)prosta-5,13-dienoic acid MeSH D23.469.700.645 --- prostaglandins a, synthetic MeSH D23.469.700.660 --- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D23)
*  NAVER Academic > Search...
... epoxymethano)prosta-5,13-dienoic Acid, Aging, physiology, Animals, Arginine, pharmacology, Coronary Circulation, drug effects, ... Animals, Anions, metabolism, Atropine, pharmacology, Butyrates, Butyric Acid, Dose-Response Relationship, Drug, Fatty Acids, ... Effects of the spin trap-alpha-phenyl-N-tert-butyl nitrone (PBN) in transient forebrain ischaemia in the rat.. 1996 K Pahlmark ... Neuronally mediated anion secretion induced by short-chain fatty acids in the rat distal small intestine.. 1996 M Diener et al. ...
  https://academic.naver.com/search.naver?field=3&query=Acta+physiologica+Scandinavica+157%EA%B6%8C+1%ED%98%B8
*  Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated...
... but not the alpha(1)-adrenoceptor agonist phenylephrine (PE). 3. The ability of U46619 to abolish EDHF-evoked smooth muscle ... 5. During smooth muscle contraction and depolarization to either PE or U46619, ACh evoked concentration-dependent ... 2. Acetylcholine (30 nm-3 microm ACh) or cyclopiazonic acid (10 microm CPA, SERCA inhibitor) were used to stimulate EDHF-evoked ... epoxymethano)prosta-5,13-dienoic Acid, Animals, Biological Factors, Dose-Response Relationship, Drug, Male, Mesenteric Arteries ...
  https://www.neuroscience.ox.ac.uk/publications/106515
*  List of MeSH codes (D10) - Wikipedia
... undecylenic acids MeSH D10.251.355.337 --- fatty acids, omega-3 MeSH D10.251.355.337.100 --- alpha-linolenic acid MeSH D10.251. ... epoxymethano)prosta-5,13-dienoic acid MeSH D10.251.355.255.100.637.100 --- prostaglandins a MeSH D10.251.355.255.100.637.150 ... arachidonic acid MeSH D10.251.355.096.450 --- Hydroxyeicosatetraenoic acids MeSH D10.251.355.096.450.425 --- 12-hydroxy-5,8,10, ... linoleic acid MeSH D10.251.355.310.640 --- linolenic acids MeSH D10.251.355.310.640.400 --- alpha-linolenic acid MeSH D10.251. ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D10)
*  NAVER Academic | Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension.
... epoxymethano)prosta-5,13-dienoic Acid, Animals, Arginine Vasopressin, pharmacology, Blood Pressure, Chronic Disease, ...
  https://academic.naver.com/article.naver?doc_id=139544983
*  Welcome to LibAge, the ageing reference resource
... epoxymethano)prosta-5,13-dienoic Acid/pharmacology *Acetylcholine/pharmacology *Aging/physiology ... gamma-Aminobutyric Acid/metabolism * 3357: Dawson et al. (2003) "Hyposulfatemia, growth retardation, reduced fertility, and ...
  http://libage.ageing-map.org/entries/tags/503/
*  PTGES3 Gene - GeneCards | TEBP Protein | TEBP Antibody
15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid. *(5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2, ... 160 amino acids. Molecular mass:. 18697 Da. Quaternary structure:. *Binds to the progesterone receptor (PubMed:8114727). ... Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 ... 15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate. *( ... 5. Cellular response to heat stress. Cellular response to heat ...
  http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=10728
*  PTGIS Gene - GeneCards | PTGIS Protein | PTGIS Antibody
15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoic acid. *(5Z)-7-{(1R,4S,5R,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2, ... Synthesis of bile acids and bile salts. Bile acid and bile salt metabolism ... alpha proteobacteria (Wolbachia pipientis). *amoeba (Dictyostelium discoideum). *Archea (Pyrococcus horikoshii). *baker's yeast ... 15S)Hydroxy-9alpha,11alpha-(epoxymethano)prosta-5,13-dienoate. *( ... fatty acid metabolic process. IEA. --. GO:0006633. fatty acid ...
  http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=5740
*  Homologous desensitization of human platelet thromboxane A2/prostaglandin H2 receptors. - Semantic Scholar
... epoxymethano)prosta-5Z,13E-dienoic acid (U46619) (1 microM). Iloprost, a stable prostacyclin analog, was included in the ... The TXA2 mimetic, [1S-1 alpha,2 beta(5Z), 3 alpha(1E,3S*), 4 alpha)]-7-[3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicyclo ... Equilibrium binding studies at pH 7.4 revealed a decrease in the number of binding sites for the receptor antagonist 9,11- ... 5-heptenoic acid (I-BOP), was used to induce platelet aggregation, shape change and increases in intracellular free calcium. ...
  https://www.semanticscholar.org/paper/Homologous-desensitization-of-human-platelet-H2-Okwu-Ullian/1f5253b5d61df9ae76a03da1a5f3e6efa7628c4c
*  Detection of prostaglandin H synthase (cyclooxygenase) -1 and -2 expression in single cancer cells by confocal Raman...
Prostaglandin H synthase (PGHS), commonly known as cyclooxygenase (COX), is the enzyme involved in the synthesis of biologically active prostanoids from arachidonic acid. There are two PGHS isozymes with identical functions, similar sizes and similar structures. PGHS-1 is constitutively expressed in most mammalian cells where as PGHS-2 is induced by various agents. PGHS-2 expression was increased with inflammation, mitogenesis, and some types of cancer. We have developed a method to simultaneously detect PGHS-1 and PGHS-2 in single cancer cells by using specific antibodies, surface-enhanced Raman scattering, and confocal Raman microspectroscopy. Cells were plated, cultured, incubated for immunocomplexation, and detected directly in the wells of a multiwell plate. The expression and localization of PGHS-1 and -2 in single malignant human hepatocytes was detected and compared to normal cells. Furthermore, the correlation between the expression of PGHS and the ...
  http://spie.org/Publications/Proceedings/Paper/10.1117/12.345410
*  CCCC 1997, Volume 62, Issue 6, Abstracts pp. 971-980 | Collection of Czechoslovak Chemical Communications
The in vitro enzymatic metabolism of carcinogenic N,N-dimethyl-4-aminoazobenzene, N-nitroso-N-methylaniline and N-nitroso-N,N-dimethylamine was investigated using ram seminal vesicle microsomal prostaglandin H synthase. Both N-nitrosamines are not converted by the studied enzyme. Formaldehyde is produced by the prostaglandin H synthase catalyzed reaction from N,N-dimethyl-4-aminoazobenzene. Arachidonic acid and hydrogen peroxide serve as cofactors for the oxidation of N,N-dimethyl-4-aminoazobenzene. The apparent Michaelis constant and the maximal velocity values for N,N-dimethyl-4-aminoazobenzene as a substrate are 64 μmol/l and 51.2 nmol HCHO/min/mg protein, respectively. In addition to formaldehyde, N-methyl-4-aminoazobenzene and 4-aminoazobenzene, two unknown substances are the products of the N,N-dimethyl-4-aminoazobenzene oxidation. The oxidation of N,N-dimethyl-4-aminoazobenzene catalyzed by prostaglandin H synthase is inhibited by ...
  http://cccc.uochb.cas.cz/62/6/0971/
*  Chapter 34. Acetaminophen | Goldfrank's Toxicologic Emergencies, 9e | AccessEmergency Medicine | McGraw-Hill Medical
prostaglandin H2 synthase (PGH2) and prevent arachidonic acid from physically entering the site and being converted to prostaglandin H2. APAP also inhibits prostaglandin H2 production but does so indirectly by reducing a heme on the peroxidase (POX) portion of the PGH2,177 and indirectly inhibiting COX activation.9,138,173 In this way, APAP function is highly dependent on cellular location and intracellular conditions.8,102,211 APAP strongly inhibits prostaglandin synthesis where concentrations of POX and arachidonic acid ("peroxide tone") are low, such as the brain.92 In conditions of high peroxide tone, such as inflammatory cells (macrophages) and platelets, prostaglandin synthesis is less affected by APAP.9,34,102,110,173,203,211 This explains APAP's strong central antipyretic and analgesic effect but weak peripheral antiinflammatory and antiplatelet effects. Functionally, APAP ...
  http://accessemergencymedicine.mhmedical.com/content.aspx?bookid=454§ionid=40199408
*  Prostanoid - Wikipedia
Prostanoids are a subclass of eicosanoids consisting of the prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the resolution phase of inflammation.) Prostaglandin H2 PGD synthase PGD2 PGJ2 PGE synthase PGE2 PGA2 PGB2 Prostacyclin synthase PGI2 6-keto-PGFα PGE 9- ketoreductase PGF2 Thromboxane-A synthase TXA2 Cyclooxygenase (COX) catalyzes the conversion of the free essential fatty acids to prostanoids by a two-step process. In the first step, two molecules of O2 are added as two peroxide linkages and a 5-member carbon ring is forged near the middle of the fatty acid chain. This forms the short-lived, unstable intermediate Prostaglandin G (PGG). One of the peroxide linkages sheds a single oxygen, forming PGH. (See diagrams and more detail at ...
  https://en.wikipedia.org/wiki/Prostanoid
*  AID 212949 - In vitro binding affinity was determined for platelet thromboxane receptor in presence of [3H]-SQ 29548 - PubChem
BioAssay record AID 212949 submitted by ChEMBL: In vitro binding affinity was determined for platelet thromboxane receptor in presence of [3H]-SQ 29548.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/212949
*  Dipetalodipin and triplatin are antithrombotic in vivo. | Open-i
Dipetalodipin and triplatin are antithrombotic in vivo.Thrombosis was induced in the carotid artery of mice via local application with 7.5% FeCl3. Blood flow wa
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4482233_pntd.0003869.g003&req=4
*  Thromboxane A2/Prostaglandin H2 Receptor Activation Mediates Angiotensin II-Induced Postischemic Neovascularization |...
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  http://atvb.ahajournals.org/content/early/2005/12/29/01.ATV.0000201969.93348.74
*  Monoclonal Antibody to Prostaglandin Endoperoxide Synthase 2 (PTGS2) | MAA699Hu22 | Homo sapiens (Human) CLOUD-CLONE CORP.(CCC)
MAA699Hu22, PGG/HS; PGHS2; PHS2; HCox2; COX2; Cyclooxygenase 2; Prostaglandin G/H Synthase And Cyclooxygenase; Prostaglandin H2 synthase 2 | Products for research use only!
  http://www.cloud-clone.com/products/MAA699Hu22.html
*  RCSB PDB - 1PGG: PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID ...
1PGG: Synthesis and use of iodinated nonsteroidal antiinflammatory drug analogs as crystallographic probes of the prostaglandin H2 synthase cyclooxygenase active site.
  http://www.rcsb.org/pdb/explore.do?structureId=1pgg
*  Structural Analysis of NSAID Binding by Prostaglandin H 2 Synthase: Time-Dependent and Time-Independent Inhibitors...
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  https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_bi010045s
*  AID 212957 - Human microsomal Thromboxane synthase inhibition was determined by inhibiting TXB2 formation from [14C]- labelled...
BioAssay record AID 212957 submitted by ChEMBL: Human microsomal Thromboxane synthase inhibition was determined by inhibiting TXB2 formation from [14C]- labelled arachidonic acid.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/212957
*  COX-2 inhibitors and gastroduodenal toxicity: Major clinical trials
The primary effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is to inhibit cyclo-oxygenase (prostaglandin H synthase, or PGHS), thereby impairing the ultimate transformation of arachidonic acid to prostaglandins, prostacyclin, and thromboxanes
  http://www.uptodate.com/contents/pulse-oximetry-in-adults/abstract/10
*  Plus it
Biosynthesis of TxA2 and the PG involves the sequential metabolism of AA in three stages. The first rate-limiting step is the stimulus-induced mobilization of AA from cell membrane phosphoglycerides by the enzymes phospholipase (PL) A2 (acting on phosphatidylcholine) and diacylglycerol (DAG) lipase (acting on phosphatidylinositol). The second is the oxidation of AA to the PG endoperoxides by the enzyme PG endoperoxide synthase, also known as cyclooxygenase (COX). This involves two sequential actions by the enzyme: first, the conversion of AA to endoperoxide PGG2 (COX activity), and, subsequently, the conversion of PGG2 to endoperoxide PGH2 (peroxidase activity). In the third and final stage, PGH2 is isomerized into the biologically active prostanoid end products by specific PG synthase enzymes (9, 59, 71). For TxA2 biosynthesis, this involves the action of TxA2 synthase (TxS) on PGH2 to produce TxA2. The profile of prostanoid end products produced within each tissue varies ...
  http://ajpheart.physiology.org/content/294/5/H1978
*  ChEMBL</PC-DBTracking...
RecName: Full=Prostaglandin G/H synthase 1; AltName: Full=Cyclooxygenase-1; Short=COX-1; AltName: Full=Prostaglandin H2 synthase 1; Short=PGH synthase 1; Short=PGHS-1; Short=PHS 1; AltName: Full=Prostaglandin-endoperoxide synthase 1; Flags: ...
  https://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=625243&version=4.1&q=expdesc_xmldisplay
*  RCSB PDB - 1EQG: THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN Macromolecule Annotations Page
1EQG: Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.
  http://www.rcsb.org/pdb/explore/derivedData.do?structureId=1EQG
*  Thromboxane synthase Antibody (1C3) (NBP2-02731): Novus Biologicals
Mouse Monoclonal Anti-Thromboxane synthase Antibody (1C3). Validated: WB, Flow, ICC/IF, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
  https://www.novusbio.com/products/thromboxane-synthase-antibody-1c3_nbp2-02731
*  Change in thromboxane synthase may lead to HB in women w/ PE - Welcome to the Preeclampsia Foundation
The Preeclampsia Foundation does not necessarily endorse any research or news found in this forum, we just want to share what is out there. Please use your own discretion to evaluate any information you find here ...
  http://www.preeclampsia.org/forum/viewtopic.php?p=348614