*  Structure and function of human 17beta-hydroxysteroid dehydrogenases. - The Arthritis Research UK Centre for Osteoarthritis...
... dependent oxidoreduction at C17 oxo/beta-hydroxyl groups of androgen and estrogen hormones. This reversible reaction ... At present, 14 mammalian 17beta-HSDs are described, of which at least 11 exist within the human genome, encoded by different ... 17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyze the NAD(P)(H) ... 17Beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyze the NAD(P)(H) dependent oxidoreduction at C17 oxo/beta-hydroxyl ...
  https://oacentre.kennedy.ox.ac.uk/publications/108329
*  Cortisol metabolism after weight loss : associations with 11 beta-HSD type 1 and markers of obesity in women
Cortisol metabolism after weight loss: associations with 11 beta-HSD type 1 and markers of obesity in women. Rask, E ... Measurements 11-HSD type 1 expression and activity, urinary glucocorticoid metabolite excretion, body composition including ... Cortisol metabolites correlated with 11-HSD type 1 activity in abdominal subcutaneous adipose tissue. The ratio of cortisol to ... Objective Increased glucocorticoid metabolite excretion and enhanced expression and activity of 11-hydroxysteroid dehydrogenase ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:629538
*  What does 11-beta-hydroxysteroid dehydrogenases stand for?
Beta' is one option -- get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resource. ... Looking for the definition of 11-beta-hydroxysteroid dehydrogenases? Find out what is the full meaning of 11-beta- ... Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. ... What does 11-beta-hydroxysteroid dehydrogenases mean? This page is about the various possible meanings of the acronym, ...
  http://www.abbreviations.com/serp.php?st=11-beta-hydroxysteroid%20dehydrogenases&qtype=3
*  On-column ligand exchange for structure-based drug design: a case study with human 11[beta]-hydroxysteroid dehydrogenase type 1...
2013-11-15. OSTI Identifier:. 1090101. Resource Type:. Journal Article. Resource Relation:. Journal Name: Acta Crystallogr. F; ... Journal Article: On-column ligand exchange for structure-based drug design: a case study with human 11[beta]-hydroxysteroid ... Title: On-column ligand exchange for structure-based drug design: a case study with human 11[beta]-hydroxysteroid dehydrogenase ...
  https://www.osti.gov/scitech/biblio/1090101-column-ligand-exchange-structure-based-drug-design-case-study-human-beta-hydroxysteroid-dehydrogenase-type
*  11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess | 11β-Hydroxysteroid dehydrogenase...
Their findings showed that the D-bifunctional protein plays an essential role in the peroxisomal beta-oxidation pathway that ... Biochemical analysis showed that the 3-hydroxyacyl-CoA dehydrogenase activity of the D-bifunctional protein was completely ... 11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Media:. ... 11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. In 2 unrelated patients, Ulick et ...
  http://oiu.steroids-australia.net/11-beta-hydroxysteroid-dehydrogenase-and-the-syndrome-of-apparent-mineralocorticoid-excess.html
*  5 alpha-reductase and 11 beta-hydroxysteroid dehydrogenase activity in prepubertal Hispanic girls with premature adrenarche. -...
We studied C19 and C21 urinary steroid metabolites, 5 alpha/5 beta and 11 oxo/11 hydroxy metabolite pairs as well as the ratios ... of the total 5 alpha/total 5 beta and total 11 oxo/total 11 hydroxy metabolites in 24-h urine samples from 17 prepubertal ... We found no differences in the 5 alpha-reductase or 11 beta-hydroxysteroid dehydrogenase activities in the prepubertal girls ... Therefore, in this group of young girls, alterations in 5 alpha-reductase or 11 beta-hydroxysteroid dehydrogenase activities do ...
  https://www.semanticscholar.org/paper/5-alpha-reductase-and-11-beta-hydroxysteroid-dehyd-Silfen-Shackleton/018ab3c0f96b12a4e7dcaa84e3ff157db6899159
*  KEE316Hu | ELISA kit for Homo sapiens (Human) 11-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD11b3) | Homo sapiens (Human) |...
Short chain dehydrogenase/reductase family 26C member 2 , Products for research use only! ... Short chain dehydrogenase/reductase family 26C member 2. * 96T (KEE316Hu) US$ 770 ... Elisa Kits › ELISA kit for Homo sapiens (Human) 11-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD11b3) ELISA kit for Homo ... The concentration of 11-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD11b3) in the samples is then determined by comparing the O ...
  http://sinoprot.com/products/KEE316Hu
*  Tissue-specific dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 and pathogenesis of the metabolic syndrome |...
Elevenbeta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1), a key intracellular enzyme which catalyses the conversion of ... If confirmed, these results would prompt the development of selective and tissue-specific 11beta-HSD-1 inhibitors to decrease ... 11β-hydroxysteroid dehydrogenase type 1; Cortisol; Cortisone; Metabolic syndrome. Settore Scientifico Disciplinare: Settore MED ... studies are less convincing with several case control and cross-sectional studies showing an association between with 11beta- ...
  https://air.unimi.it/handle/2434/200905
*  Associations between a polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene, neuroticism and postpartum depression
Authority records BETA Iliadis, Stavros I.Comasco, ErikaHellgren, CharlotteSundström Poromaa, IngerSkalkidou, Alkistis Search ... BACKGROUND: This study examined the association between a single nucleotide polymorphism in the hydroxysteroid (11-beta) ... dehydrogenase 1 gene and neuroticism, as well as the possible mediatory role of neuroticism in the association between the ... Available from: 2016-12-02 Created: 2016-12-02 Last updated: 2017-11-29Bibliographically approved ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:1051512
*  11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.
Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone ... 11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.. ... 11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. 2009, 58 (11 ... 11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. ...
  https://www.lenus.ie/handle/10147/254113
*  11beta hydroxysteroid dehydrogenase type 2 | A non-isotopic method for estimating 11 beta.
... has both dehydrogenase (11 beta DH) and reductase (11 beta R) activities, which catalyse the interconversion of cortisol and ... 11beta hydroxysteroid dehydrogenase type 2. 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) has both dehydrogenase (11 beta ... Using radiolabelled cortisol 11 beta HSD activity has been shown to be lower in some cases of essential hypertension. This ... This approach was evaluated by inducing partial deficiency of 11 beta HSD in the volunteers who took liquorice (to inhibit 11 ...
  http://amc.stoynev.us/11beta-hydroxysteroid-dehydrogenase-type-2.html
*  11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. - Radcliffe...
Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone ... A1 (selective 11beta-HSD1 inhibitor) abolished enzyme activity and blocked the increase in pSer(307) IRS1 and reduction in ... Selective 11beta-HSD1 inhibition decreases pSer(307) IRS1, increases pThr(308) Akt/PKB, and decreases lipogenic and lipolytic ... In C57Bl6/J mice, the selective 11beta-HSD1 inhibitor, A2, decreased fasting blood glucose levels and improved insulin ...
  https://www.rdm.ox.ac.uk/publications/482083
*  High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.
Heterologous production of 11beta-HSD1, devoid of its N-terminal transmembrane segment, is possible but yields only small ... Here we show that the soluble portion of recombinant 11beta-HSD1 produced in E. coli is found mainly as multimeric aggregates ... Moreover, active site titration of human 11beta-HSD1 revealed that at least 75% of the protein in a typical preparation ... By co-overexpressing GroEL/ES and adding an 11beta-HSD1 inhibitor during protein synthesis, we have increased the accumulation ...
  https://oacentre.kennedy.ox.ac.uk/publications/108418
*  Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?
The latter effect is accomplished by two different 11beta-hydroxysteroid dehydrogenase isozymes, constituting a shuttle system ... Importantly, 11beta-HSD1 activity appears to be intrinsically linked to all features of the metabolic syndrome, which could at ... Whereas the type 1 enzyme (11beta-HSD1) is in vitro a NADP(H)- dependent bidirectional enzyme, it reduces in most instances in ... The recent development of specific 11beta-HSD1 inhibitors coupled with advances on structural knowledge and regulation of the ...
  https://oacentre.kennedy.ox.ac.uk/publications/108459
*  Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. - Department of Pharmacology
The benzothiazole derivatives 1 and 2 showed greater than 80% inhibition for 11beta-HSD1 at 10 microM and exhibited IC50 values ... Docking studies with the benzothiazole derivative 1 into the crystal structure of human 11beta-HSD1 revealed how the molecule ... 11beta-HSD1) have considerable potential as treatments for metabolic diseases, such as diabetes mellitus type 2 or obesity. ... the discovery and synthesis of a series of novel benzothiazole derivatives and their inhibitory activities against 11beta-HSD1 ...
  https://pharm.ox.ac.uk/publications/640377
*  Characterisation of 11beta-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and...
The pre-receptor regulation of GCs by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) that activates cortisol from ... Primary cultures of OF preadipocytes demonstrated predominant 11beta-HSD1 oxo-reductase activity with minimal dehydrogenase ... Orbital adipocytes are smaller, less differentiated, and express low levels of 11beta-HSD1 but abundant GRalpha compared with ... 11beta-HSD1 mRNA together with the markers of late adipocyte differentiation (FABP4 and G3PDH) were significantly lower in OF. ...
  https://www.rdm.ox.ac.uk/publications/482097
*  Effects of peroxisome proliferator-activated receptor-alpha and -gamma agonists on 11beta-hydroxysteroid dehydrogenase type 1...
Reduced adipose 11beta-HSD1 expression and increased plasma cortisol during longer therapy with rosiglitazone probably reflect ... In 12 healthy men, 4-5 wk of rosiglitazone increased insulin sensitivity during insulin infusion but did not change 11beta-HSD1 ... OBJECTIVE: Our objective was to test whether PPAR agonists alter cortisol secretion and peripheral regeneration by 11beta-HSD1 ... CONCLUSIONS: Neither PPARalpha nor PPARgamma agonists down-regulate 11beta-HSD1 or cortisol secretion acutely in humans. The ...
  https://www.rdm.ox.ac.uk/publications/17985
*  Compound Report Card
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens 0.997 CHEMBL1293237 Bloom syndrome protein Homo sapiens 0.981 ... 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus 0.965 CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens ... 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens 1.000 CHEMBL4931 ...
  https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL1473
*  11β-Hydroxysteroid dehydrogenase type 1 - Wikipedia
Pácha J, Lisá V, Miksík I (February 2002). "Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity ... Wake DJ, Walker BR (February 2006). "Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity". Endocrine. 29 (1): ... Agarwal AK (November 2003). "Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I ... "11beta-Hydroxysteroid dehydrogenase types 1 and 2 are up- and downregulated in cortisol-secreting adrenal adenomas". Journal of ...
  https://en.wikipedia.org/wiki/11%CE%B2-Hydroxysteroid_dehydrogenase_type_1
*  Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet...
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-110pmid:12502499. ... Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol ... 11Beta-hydroxysteroid dehydrogenase type 1 and obesity. Front Horm Res 2008;36:146-164pmid:18230901. ... 11Beta-hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets. Diabetologia 2008;51: ...
  http://diabetes.diabetesjournals.org/content/61/3/642
*  Compound Report Card
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens 0.974 CHEMBL3056 Androgen Receptor Mus musculus 0.960 ... 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens 0.826 CHEMBL2391 11-beta-hydroxysteroid dehydrogenase 1 Rattus norvegicus ...
  https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL384467
*  DHRS7B - Wikipedia
Dehydrogenase/reductase (SDR family) member 7B is an enzyme encoded by the DHRS7B gene in humans, found on chromosome 17p11.2. ... DHRS7B is a member of the short chain dehydrogenase/reductase (SDR) superfamily and possesses characteristic features of an SDR ... Dehydrogenase/reductase (SDR family) member 7B". "Genecards: DHRS7B Gene protein-coding GIFtS 47". Tannin GM, Agarwal AK, ... Downstream of DHSRS7B on the negative strand of chromosome 17p11.2 is the gene Transmembrane protein 11 (TMEM11), and on the ...
  https://en.wikipedia.org/wiki/DHRS7B
*  Patent US5686104 - Stable oral CI-981 formulation and process of preparing same - Google Patents
Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta, gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1 ... Crystalline Forms Of [R-(R*,R*)-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methyl- Ethyl)-3-phenyl-4-[(phenylamino)carbonyl]- ... Novel Forms of [R-(R*,R*)]-2-(4-Fluorophenyl)-Beta,Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbonyl]-1H- ... Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h- ...
  http://www.google.co.uk/patents/US5686104
*  Regulation of 11β-Hydroxysteroid Dehydrogenase Type 2 by MicroRNANovelty and Significance | Hypertension
Reduced 11beta-hydroxysteroid dehydrogenase activity in patients with the nephrotic syndrome. J Clin Endocrinol Metab. 1999;84: ... Structural analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene in end-stage renal disease. Kidney Int. 2000;58:1413 ... Reduced 11beta-hydroxysteroid dehydrogenase activity in the remaining kidney following nephrectomy. Endocrinology. 1998;139: ... Molecular basis of human salt sensitivity: the role of the 11beta-hydroxysteroid dehydrogenase type 2. J Clin Endocrinol Metab ...
  http://hyper.ahajournals.org/content/64/4/860
*  Hsd11b1 - Corticosteroid 11-beta-dehydrogenase isozyme 1 - Mus musculus (Mouse) - Hsd11b1 gene & protein
Legend: HelixTurnBeta strandPDB Structure known for this area. Show more detailsHide details. Feature key. Position(s). ... p>This subsection of the 'Structure' section is used to indicate the positions of experimentally determined beta strands within ... p>This subsection of the 'Structure' section is used to indicate the positions of experimentally determined beta strands within ... p>This subsection of the 'Structure' section is used to indicate the positions of experimentally determined beta strands within ...
  http://www.uniprot.org/uniprot/P50172