Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function ...

Loeys-Dietz syndrom är en genetisk sjukdom som orsakas av en mutation (genförändring) i antingen TGFBR1 eller TGFBR2 generna (transforming growth factor beta receptor 1 eller 2), i SMAD3 genen (mothers against decapentaplegic homolog 3), i TGFB2 genen (tgfbeta 2 eller transforming growth factor beta 2 ligand) eller i TGFB3 genen (tgfbeta 3 eller transforming growth…

2019-09-17T14:00:00.000+02:00 2019-09-17T14:00:00.000+02:00 A Needs-Based Approach towards Fostering Long-term Engagement with Energy Feedback among Local Residents (Licentiatseminarier) A Needs-Based Approach towards Fostering Long-term Engagement with Energy Feedback among Local Residents (Licentiatseminarier) ...

2019-09-17T14:00:00.000+02:00 2019-09-17T14:00:00.000+02:00 A Needs-Based Approach towards Fostering Long-term Engagement with Energy Feedback among Local Residents (Licentiatseminarier) A Needs-Based Approach towards Fostering Long-term Engagement with Energy Feedback among Local Residents (Licentiatseminarier) ...

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