• It activates transcription of several B-cell-specific genes, including the {lambda}5 gene, which encodes a protein necessary for signaling by the pre-B-cell receptor. (lu.se)
  • Differential activation of mitogen-activated protein kinases and brain-derived neurotrophic factor after temporary or permanent damage to a sensory system. (ki.se)
  • Cannabinoid receptor 1, ofta förkortat CB1, är ett sjudomänt transmembrant protein kopplat till G-proteiner som hittas i centrala och perifera nervsystemet , men även i levern , sköldkörteln , lungor, mag- och tarmkanalen , njurarna, spermier, immunceller och reproduktiva vävnader. (wikipedia.org)
  • However, given that the development of regulatory T cell responses could be dependent on optimal antigen presentation, autoimmune disease may be due to ineffective APC function. (lu.se)
  • Our data reveal an intriguing inhibitory property of EBF-a property shared only by E1A, Twist, Pu.1, and the Hox family of homeodomain proteins-and suggest that E47 and EBF play distinct roles during {lambda}5 promoter activation. (lu.se)
  • In analogy, we found that Linomide treatment of SJL/J mice results in the upregulation of MHC class II, CD11a, CD54 and CD80 on Mphi, indicating an improved T cell stimulatory capacity. (lu.se)
  • Estrogen receptor beta protects against acoustic trauma in mice. (ki.se)
  • We have shown that DC and Mphi that infiltrate the islets of Langerhans produce tumour necrosis factor-a (TNF-a), a cytokine known to contribute to the pathogenesis in the early stages of diabetes development. (lu.se)
  • TNF-a is produced from the early stages of insulitis development and occurs independently of T cells. (lu.se)
  • This gives rise to a reduced T cell activation as well as an impaired upregulation of the negative T cell regulator CTLA-4, suggesting that APC defects contribute to disease development. (lu.se)
  • In addition, the ability of several Linomide analogues to inhibit experimental autoimmune encephalomyelitis correlates with their ability to upregulate MHC class II on Mphi, suggesting that APC activation may indeed inhibit autoimmune disease. (lu.se)
  • Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain. (gu.se)