• Britain, Special report series 272, HMSO 1950 demonstrated that many of the diphtheria patients had high levels of circulating antibodies, whereas many of the contacts who remained perfectly well had low antibody. (vaccin.me)
  • Ben will give an overview of the project, and describe the progress so far, focusing on vaccine lessons from our animal immunizations and on high throughput strategies for monoclonal antibody discovery. (ki.se)
  • Whenever we read vaccine papers the MD researchers always assume that if there are high antibody levels after vaccination, then there is immunity (immunogencity). (vaccin.me)
  • Efficient inhibition of the virion-mediated fusion event was consistently observed for the human AD-2-specific antibody as determined by a reporter gene activation assay based on permissive astrocytoma cells. (lu.se)
  • Our experiments in mice that lack antibodies but possess B cells and normal lymphoid tissues confirm that both B cells and antibodies are critical to survive a systemic infection after i.v. bolus administration of VSV. (vaccin.me)
  • However, only B cells are essential when VSV is encountered via the more "natural" s.c. [subcutaneous] route, whereas antibodies are neither needed nor sufficient for protection. (vaccin.me)
  • In this study we investigated the extent to which different vaccines, attenuated live Towne vaccine with or without priming with a canarypox virus coding for gB, or a recombinant gB vaccine adjuvanted with MF59, induced antibodies to this epitope. (lu.se)
  • Virus attachment via heparan sulfate was unaffected by the antibodies under the conditions used. (lu.se)
  • Virus receptor binding as examined by heparin treatment of adsorbed virus was significantly reduced only if the virus had been coated with the AD-2-specific antibody. (lu.se)
  • Neutralization of virus infectivity by the AD-2-specific antibody thus seems most likely to result from interference with a receptor-binding event during initial virus-host cell interaction. (lu.se)
  • Three mumps vaccines-Rubini, Jeryl-Lynn and Urabe (the one withdrawn because it caused encephalitis) all produced excellent antibody levels but those vaccinated with the Rubini strain had the same attack rate as those not vaccinated at all, there were some who said that it actually caused outbreaks. (vaccin.me)
  • The results presented here contradict the current view that B cell-derived neutralizing antibodies are absolutely required to survive a primary cytopathic viral infection, such as that caused by VSV. (vaccin.me)
  • Yet Dr March says antibody response is generally a poor measure of protection and no indicator at all of safety. (vaccin.me)
  • Particularly for viral diseases, the 'cellular' immune response is all important, and antibody levels and protection are totally unconnected . (vaccin.me)