Suprasellar malignant teratoma with 11-year survival--case report.
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Long-term survival of malignant teratoma is rare. A 16-year-old female with a suprasellar malignant teratoma survived for 11 years before succumbing to embryonal carcinoma. A suprasellar immature teratoma with increased serum alpha-fetoprotein level was verified histologically. Radiation therapy and combined chemotherapy were given after partial removal. Eleven years later, the primary lesion recurred as embryonal carcinoma. (+info)
Ossifying fibroma of the sella turcica.
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Ossifying fibroma of the sellar turcica is extremely rare. There are only sporadic case reports in the literature. One such case simulating pituitary adenoma is presented in an 18-year-old girl. (+info)
Suprasellar ectopic pituitary adenoma presenting as cranial diabetes insipidus.
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We describe the occurrence of a supracellar ectopic pituitary adenoma in a 34 year old woman who presented with cranial diabetes insipidus and subsequently developed galactorrhoea-amenorrhoea. The tumour was demonstrated by both contrast computed tomography scan and magnetic resonance imaging with gadolinium enhancement and was confirmed at operation. Histological examination showed that the suprasellar lesion consisted of a pituitary adenoma while the pituitary biopsy revealed an unrelated pituitary microadenoma embedded in normal pituitary tissues. A review is made of the reported cases of ectopic pituitary adenomas. (+info)
Tanycytomas: a newly characterized hypothalamic-suprasellar and ventricular tumor.
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We report five cases of tumors occurring in three children and in two adults. The tumors had unusual histomorphology and a mixture of ependymal and piloid-like astrocytic features and a myxoid stroma similar to myxopapillary ependymomas. MR imaging in three of the cases showed aggressive, intensely enhancing partially cystic hypothalamic-suprasellar masses near midline and near the floor of the third ventricle. In the three pediatric cases, the tumor encased the circle of Willis. This newly characterized tumor, the tanycytoma, has neoplastic cells with histomorphologic and ultrastructural characteristics similar to those of the tanycyte. (+info)
Measurement of Ki-67 antigen in 159 pituitary adenomas using the MIB-1 monoclonal antibody.
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Pituitary adenomas sometimes show rapid growth and recurrence, and about one third invade the structures surrounding the sella turcica. In an attempt to determine aggressive behavior at an early stage, we used the MIB-1 antibody to identify the Ki-67 antigen. The present study was designed to evaluate pituitary adenomatous tissue in terms of secretion and proliferation and to correlate the Ki-67 index with hormone phenotype and invasive behavior. Material from 159 patients submitted to one or more resections of pituitary adenomas was evaluated. Forty-two non-secretory adenomas and 43 adenomas immunoreactive for growth hormone, 19 for prolactin, 18 for growth hormone and prolactin, 16 for adrenocorticotropic hormone (ACTH), and 21 cases of plurihormonal/gonadotropin adenomas were detected by immunohistochemistry. The MIB-1 antibody was positive in 139 samples and the Ki-67 index ranged from 0.16 to 15.48% (mean = 1.22 +/- 2.09%), with no significant difference between genders, age groups, or secretory and non-secretory status. The Ki-67 index was higher in ACTH-secreting adenomas. Invasive pituitary adenomas had a significantly higher Ki-67 index (2.01 +/- 3.15%) than macroadenomas with or without supra-sellar extension (1.12 +/- 1.87%; P = 0.02). The index was not significantly different in the subgroup of adenomas with invasion of the cavernous sinus compared to groups with other types of invasion. We conclude that tumoral proliferative activity evaluated by the detection of the Ki-67 antigen is significantly higher in invasive than noninvasive adenomas, information which can be useful in therapeutic postoperative management since index cut-off values associated with aggressive behavior can be established. (+info)
The effect of a modified reverse headgear force applied with a facebow on the dentofacial structures.
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The purpose of this study was to evaluate the effects of a modified reverse headgear force applied with a facebow on the dentofacial structures of patients with skeletal Class III malocclusions characterized by maxillary retrognathism. Thirty individuals before the pubertal peak and in the mixed dentition were selected. Fifteen subjects (seven males, eight females, mean age 9.2 years) who formed the treatment group were compared with a control group comprising seven males and eight females (mean age 8.6 years). Maxillary deficiency and negative overjet were noted in all individuals included in the treatment and control groups. The combination of a full coverage maxillary removable appliance and an embedded facebow was used for treatment. The outer arms of the facebow were bent to deliver the force through the approximate centre of resistance of the maxilla. Extra-oral elastics extended from the reverse headgear to the outer arms of the facebow. Statistical analysis indicated significant changes in angles SNA, NV-A, SV-ANS, SV-PNS and PP measurements, suggesting that the maxilla moved anteriorly. There was, however, no statistically significant difference in SN-MP, SN-PP and MP-PP measurements between the treatment and control groups. These results suggest that there was no maxillary or mandibular rotation, but that the molars moved mesially in the protraction group. The U6-PP(V) dimension did not display significant differences between the pre- and post-treatment measurements in the treated group. Anterior movement of the maxilla was obtained without rotation of the jaws and upper and lower maxillary heights were unaffected. (+info)
The post-haemorrhagic vasopressin release into the blood.
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The aim of the present study was to compare the influence of the renin-angiotensin and sympathetic system in the process of post-haemorrhagic vasopressin release. A dialysis of the venous blood from the sella turcica region was performed in male rats under anaesthesia. The animals were divided into eight experimental groups: 1). control; 2). bleeding; 3). 20 days after superior cervical ganglionectomy; 4). 20 days after superior cervical ganglionectomy and bleeding; 5). injection of captopril; 6). injection of captopril and bleeding; 7). 20 days after superior cervical ganglionectomy and injection of captopril; 8). 20 days after superior cervical ganglionectomy, injection of captopril and bleeding. The content of vasopressin in dialysates was determined by radioimmunoassay. In control rats the release of vasopressin into dialysates was constant during 180 min of the experiment. Bleeding, as well as, superior cervical ganglionectomy caused an increase in vasopressin release. Captopril did not change vasopressin release in comparison to control group. Furthermore, vasopressin release after both, bleeding and sympathetic denervation performed simultaneously was significantly abolished. We conclude that renin-angiotensin, as well as, sympathetic nervous system are involved in the increased post-haemorrhagic vasopressin release. (+info)
Investigation of natural head posture in different head types.
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The aim of this study was to investigate natural head posture (NHP) in different head types. Lateral cephalograms of 99 adults (Mean age, 21.8 years +/- SD, 2.2 yrs, range between 19 and 29 yrs) were examined. Head types were determined as Hyperbrachycephal, Brachycephal, Mesocephal or Dolichocephal according to the cephalic index. Analysis of variance and the Duncan's test were performed to assess inter-group differences for the parameters. The findings revealed that, NHP was statistically not different between the head type groups. Thus, it was suggested that environmental factors during growth may alter NHP, as well as craniofacial morphology but in a different manner (i.e. degree and direction) in each head type. (+info)