Delay or probability discounting in a model of impulsive behavior: effect of alcohol. (1/1353)

Little is known about the acute effects of drugs of abuse on impulsivity and self-control. In this study, impulsivity was assessed in humans using a computer task that measured delay and probability discounting. Discounting describes how much the value of a reward (or punisher) is decreased when its occurrence is either delayed or uncertain. Twenty-four healthy adult volunteers ingested a moderate dose of ethanol (0.5 or 0.8 g/kg ethanol: n = 12 at each dose) or placebo before completing the discounting task. In the task the participants were given a series of choices between a small, immediate, certain amount of money and $10 that was either delayed (0, 2, 30, 180, or 365 days) or probabilistic (i.e., certainty of receipt was 1.0, .9, .75, .5, or .25). The point at which each individual was indifferent between the smaller immediate or certain reward and the $10 delayed or probabilistic reward was identified using an adjusting-amount procedure. The results indicated that (a) delay and probability discounting were well described by a hyperbolic function; (b) delay and probability discounting were positively correlated within subjects; (c) delay and probability discounting were moderately correlated with personality measures of impulsivity; and (d) alcohol had no effect on discounting.  (+info)

Base rates versus sample accuracy: competition for control in human matching to sample. (2/1353)

People often place undue weight on specific sources of information (case cues) and insufficient weight on more global sources (base rates) even when the latter are highly predictive, a phenomenon termed base-rate neglect. This phenomenon was first demonstrated with paper-and-pencil tasks, and also occurs in a matching-to-sample procedure in which subjects directly experience case sample (cue) accuracy and base rates, and in which discrete, nonverbal choices are made. In two nonverbal experiments, subjects were exposed to hundreds of trials in which they chose between two response options that were both probabilistically reinforced. In Experiment 1, following one of two possible samples (the unpredictive sample), either response was reinforced with a .5 probability. The other sample (predictive) provided reinforcement for matching on 80% of the trials in one condition but in only 20% of the trials in another condition. Subjects' choices following the unpredictive sample were determined primarily by the contingencies in effect for the predictive sample: If matching was reinforced following the predictive sample, subjects tended to match the unpredictive sample as well; if countermatching the predictive sample was generally reinforced, subjects tended to countermatch the unpredictive sample. These results demonstrate only weak control by base rates. In Experiment 2, base rates and sample accuracy were simultaneously varied in opposite directions to keep one set of conditional probabilities constant. Subjects' choices were determined primarily by the overall accuracy of the sample, again demonstrating only weak control by base rates. The same pattern of choice occurred whether this pattern increased or decreased rate of reinforcement. Together, the results of the two experiments provide a clear empirical demonstration of base-rate neglect.  (+info)

Implementing evidence based medicine in general practice: audit and qualitative study of antithrombotic treatment for atrial fibrillation. (3/1353)

OBJECTIVE: To determine the extent to which implementation of an evidence based treatment, antithrombotic treatment in atrial fibrillation, is possible in general practice. DESIGN: Audit and qualitative study of patients with atrial fibrillation and an educational intervention for patients judged eligible for antithrombotic treatment. SETTING: South east England. SUBJECTS: 56 patients with a history of atrial fibrillation. INTERVENTIONS: Assessment and interview to ascertain patients' views on antithrombotic treatment. MAIN OUTCOME MEASURES: Number of patients receiving antithrombotic treatment. RESULTS: Out of 13 239 patients, 132 had a history of atrial fibrillation of which 100 were at risk of thromboembolism. After the study, 52 patients were taking warfarin. Of the remaining 48 patients (of whom 41 were taking aspirin), eight were too ill to participate, 16 were unable to consent, four refused the interview, and 20 declined warfarin. Patients declining warfarin were inclined to seek a higher level of benefit than those taking it, as measured by the minimal clinically important difference. Qualitative data obtained during the interviews suggested that patients' health beliefs were important factors in determining their choice of treatment. CONCLUSION: Patients' unwillingness to take warfarin seemed to be a major factor in limiting the number who would eventually take it.  (+info)

Perceived distance, shape and size. (4/1353)

If distance, shape and size are judged independently from the retinal and extra-retinal information at hand, different kinds of information can be expected to dominate each judgement, so that errors in one judgement need not be consistent with errors in other judgements. In order to evaluate how independent these three judgments are, we examined how adding information that improves one judgement influences the others. Subjects adjusted the size and the global shape of a computer-simulated ellipsoid to match a tennis ball. They then indicated manually where they judged the simulated ball to be. Adding information about distance improved the three judgements in a consistent manner, demonstrating that a considerable part of the errors in all three judgements were due to misestimating the distance. Adding information about shape that is independent of distance improved subjects' judgements of shape, but did not influence the set size or the manually indicated distance. Thus, subjects ignored conflicts between the cues when judging the shape, rather than using the conflicts to improve their estimate of the ellipsoid's distance. We conclude that the judgements are quite independent, in the sense that no attempt is made to attain consistency, but that they do rely on some common measures, such as that of distance.  (+info)

An orientation anisotropy in the effects of scaling vertical disparities. (5/1353)

Garding et al. (Vis Res 1995;35:703-722) proposed a two-stage theory of stereopsis. The first uses horizontal disparities for relief computations after they have been subjected to a process called disparity correction that utilises vertical disparities. The second stage, termed disparity normalisation, is concerned with computing metric representations from the output of stage one. It uses vertical disparities to a much lesser extent, if at all, for small field stimuli. We report two psychophysical experiments that tested whether human vision implements this two-stage theory. They tested the prediction that scaling vertical disparities to simulate different viewing distances to the fixation point should affect the perceived amplitudes of vertically but not horizontally oriented ridges. The first used elliptical half-cylinders and the 'apparently circular cylinder' judgement task of Johnston (Vis Res 1991;31:1351-1360). The second experiment used parabolic ridges and the amplitude judgement task of Buckley and Frisby (Vis Res 1993;33:919-934). Both studies broadly confirmed the anisotropy prediction by finding that large scalings of vertical disparities simulating near distances had a strong effect on the perceived amplitudes of the vertically oriented stimuli but little effect on the horizontal ones. When distances > 25 cm were simulated there were no significant differential effects and various methodological reasons are offered for this departure from expectations.  (+info)

Human heading judgments and object-based motion information. (6/1353)

In four experiments, we explored observers' ability to make heading judgments from simulated linear and circular translations through sparse forests and with pursuit fixation on one tree. We assessed observers' performance and information use in both regression and factorial designs. In all experiments we found that observers used three sources of object-based information to make their judgments--the displacement direction of the nearest object seen (a heuristic), inward displacement towards the fovea (an invariant) and outward deceleration (a second invariant). We found no support for the idea that observers use motion information pooled over regions of the visual field.  (+info)

One-shot viewpoint invariance in matching novel objects. (7/1353)

Humans often evidence little difficulty at recognizing objects from arbitrary orientations in depth. According to one class of theories, this competence is based on generalization from templates specified by metric properties (MPs), that were learned for the various orientations. An alternative class of theories assumes that non-accidental properties (NAPs) might be exploited so that even novel objects can be recognized under depth rotation. After scaling MP and NAP differences so that they were equally detectable when the objects were at the same orientation in depth, the present investigation assessed the effects of rotation on same-different judgments for matching novel objects. Judgments of a sequential pair of images of novel objects, when rendered from different viewpoints, revealed relatively low costs when the objects differed in a NAP of a single part, i.e. a geon. However, rotation dramatically reduced the detectability of MP differences to a level well below that expected by chance. NAPs offer a striking advantage over MPs for object classification and are therefore more likely to play a central role in the representation of objects.  (+info)

Perceptual motion standstill in rapidly moving chromatic displays. (8/1353)

In motion standstill, a quickly moving object appears to stand still, and its details are clearly visible. It is proposed that motion standstill can occur when the spatiotemporal resolution of the shape and color systems exceeds that of the motion systems. For moving red-green gratings, the first- and second-order motion systems fail when the grating is isoluminant. The third-order motion system fails when the green/red saturation ratio produces isosalience (equal distinctiveness of red and green). When a variety of high-contrast red-green gratings, with different spatial frequencies and speeds, were made isoluminant and isosalient, the perception of motion standstill was so complete that motion direction judgments were at chance levels. Speed ratings also indicated that, within a narrow range of luminance contrasts and green/red saturation ratios, moving stimuli were perceived as absolutely motionless. The results provide further evidence that isoluminant color motion is perceived only by the third-order motion system, and they have profound implications for the nature of shape and color perception.  (+info)