Prominent hippocampal CA3 gene expression profile in neurocognitive aging. (1/57)

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White matter hyperintensities and cognition: testing the reserve hypothesis. (2/57)

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IQ trajectory, cognitive reserve, and clinical outcome following a first episode of psychosis: a 3-year longitudinal study. (3/57)

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Cognitive reserve and brain volumes in pediatric acute lymphoblastic leukemia. (4/57)

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Delaying the onset of Alzheimer disease: bilingualism as a form of cognitive reserve. (5/57)

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Intracranial volume and dementia: some evidence in support of the cerebral reserve hypothesis. (6/57)

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Cognitive reserve in aging. (7/57)

Cognitive reserve explains why those with higher IQ, education, occupational attainment, or participation in leisure activities evidence less severe clinical or cognitive changes in the presence of age-related or Alzheimer's disease pathology. Specifically, the cognitive reserve hypothesis is that individual differences in how tasks are processed provide reserve against brain pathology. Cognitive reserve may allow for more flexible strategy usage, an ability thought to be captured by executive functions tasks. Additionally, cognitive reserve allows individuals greater neural efficiency, greater neural capacity, and the ability for compensation via the recruitment of additional brain regions. Taking cognitive reserve into account may allow for earlier detection and better characterization of age-related cognitive changes and Alzheimer's disease. Importantly, cognitive reserve is not fixed but continues to evolve across the lifespan. Thus, even late-stage interventions hold promise to boost cognitive reserve and thus reduce the prevalence of Alzheimer's disease and other age-related problems.  (+info)

Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline. (8/57)

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