BrazilPopulation Density: Number of individuals in a population relative to space.Rivers: Large natural streams of FRESH WATER formed by converging tributaries and which empty into a body of water (lake or ocean).Seasons: Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Psychodidae: Small, hairy, moth-like flies which are of considerable public health importance as vectors of certain pathogenic organisms. Important disease-related genera are PHLEBOTOMUS, Lutzomyia, and Sergentomyia.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Insect Vectors: Insects that transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.Trees: Woody, usually tall, perennial higher plants (Angiosperms, Gymnosperms, and some Pterophyta) having usually a main stem and numerous branches.Indians, South American: Individual members of South American ethnic groups with historic ancestral origins in Asia.Socioeconomic Factors: Social and economic factors that characterize the individual or group within the social structure.Endemic Diseases: The constant presence of diseases or infectious agents within a given geographic area or population group. It may also refer to the usual prevalence of a given disease with such area or group. It includes holoendemic and hyperendemic diseases. A holoendemic disease is one for which a high prevalent level of infection begins early in life and affects most of the child population, leading to a state of equilibrium such that the adult population shows evidence of the disease much less commonly than do children (malaria in many communities is a holoendemic disease). A hyperendemic disease is one that is constantly present at a high incidence and/or prevalence rate and affects all groups equally. (Last, A Dictionary of Epidemiology, 3d ed, p53, 78, 80)Bertholletia: A plant genus of the family Lecythidaceae which is the source of edible Brazil nuts.Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Urban Population: The inhabitants of a city or town, including metropolitan areas and suburban areas.Epidemiologic Methods: Research techniques that focus on study designs and data gathering methods in human and animal populations.Simuliidae: Several species of the genus Simulium (family Simuliidae) that act as intermediate hosts (vectors) for the parasitic disease ONCHOCERCIASIS.

*  Maternal health in Brazil: priorities and challenges
Brazil is a signatory to the Millennium Declaration, and the most recent Brazilian National Progress Report on the Millennium ... To achieve the goal of improved women's health, Brazil must reach a maternal mortality ratio of no more than 35 deaths per 100 ... According to data from the National Demographic and Health Survey (PNDS) for 2006, 89% of pregnant women in Brazil attended at ... Improved maternal health based on reducing the MMR is a current priority and challenge for Brazil. In addition to guaranteeing ...
  http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X2011000700001&lng=en&nrm=iso&tlng=en
*  B Cell Lymphoma: January 2013
In Brazil, it is the fifth cause of cancer, with more than 55,000 cases and 26,000 deaths per year. At Hospital das Clínicas da ... Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo - USP, São Paulo, SP, Brazil. ...
  http://bcellllymphoma.blogspot.com/2013/01/
*  BELLON BRAZIL
... ... BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BRAZIL ... BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL ... BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL BELLON BRAZIL ...
  http://www.network54.com/Forum/418558/message/1369756835/add+no+facebook
*  Oswaldo Cruz Foundation - Wikipedia
Today the institution has a broad range of responsibilities related to the health and wellbeing of the Brazilian population. ... Brazil, it is considered one of the world's main public health research institutions. It was founded by Dr. Oswaldo Cruz, a ... the Brazilian public health system), its proposals on public health policy-making, its research activities, its scientific ...
  https://en.m.wikipedia.org/wiki/Oswaldo_Cruz_Foundation
*  Video laparoscopic intervention for an interstitial Intervenção videolaparoscópica na gestação intersticial
24 Itaim Bibi - São Paulo (SP) - Brasil CEP 04530001 Tel. (+55 11) 3078-5011 E-mail: [email protected] Sao Paulo Med J. 2012; ... Gynecological Clinic, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil. II MD, ... Head of Fetal Medicine, Mother and Child Department, Hospital Israelita Albert Einstein (HIAE), São Paulo, Brazil. IV KEY WORDS ... Obstetrician and Gynecologist, Mother and Child Department, Hospital Israelita Albert Einstein (HIAE), São Paulo, Brazil. III ...
  http://spotidoc.com/doc/11266/video-laparoscopic-intervention-for-an-interstitial-inter..
*  Abstract
rd 23 Congress of the International Union for Biochemistry and Molecular Biology th 44 Annual Meeting of the Brazilian Society ... Brazil; Grupo de Genômica e Biologia Computacional, Centro de Excelência em Bioinformática - CEBio, Centro de Pesquisas René ... Brazil. Introduction: Schistosomiasis is a disease caused by trematodes of Schistosoma genus. These parasites exhibit a complex ... for Biochemistry and Molecular Biology th th Foz do Iguaçu, PR, Brazil, August 24 to 28 , 2015 FUNCTIONAL CHARACTERIZATION OF ...
  http://livrozilla.com/doc/884689/abstract
*  Repositório Institucional - Universidade Federal de Uberlândia: Avaliação de genótipos de soja (Glycine max (L.) Merril) quanto...
Brasil. Publisher: Universidade Federal de Uberlândia. metadata.dc.publisher.program: Programa de Pós-graduação em Agronomia. ...
  https://repositorio.ufu.br/handle/123456789/18945
*  Coadjuvant Proceeding - Hyperbaric Oxygentherapy
Almeida (1882-1952), MD, brazilian, is considered pioneering world-wide of the use of the hyperbaric hyperoxia, having carried ...
  http://www.feridologo.com.br/1oxigenoterapia.htm
*  Association of a PARK2 Germline Variant and Epithelial Ovarian Cancer in a Southern Brazilian Population Ovarian Cancer...
Ovarian cancer (OC) is the eighth most common cancer among women in Brazil and seventh in the world population. OC has a high ... Association of a PARK2 Germline Variant and Epithelial Ovarian Cancer in a Southern Brazilian Population ...
  https://ovariancancerandus.blogspot.com/2016/06/association-of-park2-germline-variant.html
*  AASV News archive - USDA Changes Disease Status of the Brazilian State of Santa Catarina with Regard to Certain Ruminant and...
USDA Changes Disease Status of the Brazilian State of Santa Catarina with Regard to Certain Ruminant and Swine Diseases. ... Currently, FSIS does not allow the importation of meat processed in Brazil. ... is amending its regulations governing the importation of certain animals and animal products by adding the Brazilian State of ...
  https://www.aasv.org/news/story.php?id=4545
*  Aspectos Bioéticos da Judicialização da Saúde por Medicamentos em 13 Municípios no Meio-Oeste de Santa Catarina, Brasil
Health´s judicialization is a recent phenomenon in Brazil, with serious repercussions for the Brazilian public health system. ... The aim of this work was to study its occurrence in thirteen small towns in the Midwest of Santa Catarina, southern Brazil, in ... Brazil. Acta bioeth. [online]. 2016, vol.22, n.2, pp.293-302. ISSN 1726-569X. http://dx.doi.org/10.4067/S1726-569X2016000200016 ...
  http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S1726-569X2016000200016&lng=pt&nrm=iso&tlng=en
*  Richness of ground-dwelling ants in the praia da Pedreira, Parque Estadual de Itapua, Viamao, RS, Brazil Riqueza de formigas de...
Brazil Riqueza de formigas de solo na praia da Pedreira, Parque Estadual de Itapua, Viamao, RS, Brasil ... Brazil Riqueza de formigas de solo na praia da Pedreira, Parque Estadual de Itapua, Viamao, RS, Brasil. Revista Brasileira de ... Richness of ground-dwelling ants in the praia da Pedreira, Parque Estadual de Itapua, Viamao, RS, Brazil Riqueza de formigas de ... Richness of ground-dwelling ants in the Praia da Pedreira, Parque Estadual de Itapua, Viamao, RS, Brazil, Aiming to improve the ...
  https://eurekamag.com/research/038/622/038622847.php
*  Vulnerability and factors associated with HIV and syphilis among men who have sex with men , Belo Horizonte , MG - Semantic...
Divinópolis, MG - Brazil. 5 Nurse. Doctoral Student in Public Health, UFMG. Belo Horizonte, MG - Brazil. 6 Infectologist. PhD ... Belo Horizonte, MG - Brazil. 7 Physician. PhD in Public Health. Full Professor with the Department of Social Pharmacy, UFMG. ... Belo Horizonte, MG - Brazil. 4 Infectologist. Doctoral student in Public Health, UFMG. Professor at Universidade Federal de São ... Belo Horizonte, MG - Brazil. 3 Dental Surgeon. Doctoral Student in Public Health, UFMG. Epidemiologist, Municipal Health Office ...
  https://www.semanticscholar.org/paper/Vulnerability-and-factors-associated-with-HIV-and-Guimar%C3%A3es-Ceccato/d34fc300bbcbe2b4673ac3ed153b4c855fb20f99
*  DISTINGUISHED PHYSICIANS OF BAHIA: 124- FERNANDO VISCO DIDIER
Reports Rodrigues Thomaz Cruz, Sergipe renowned, former director of medical studies primate of Brazil, during his tenure, ... SALVADOR, BAHIA (BRAZIL). http://www.google.com/images?hl=en&biw=1362&bih=595&gbv=2&tbs=isch%3A1&sa=1&q=SALVADOR&btnG=Search&aq ...
  http://distinguishedphysiciansofbahia.blogspot.com/2011/03/124-fernando-visco-didier.html
*  Brazil
... is the eighth-largest economy in the world, but is recovering from a recession in 2015 and 2016 that ranks as the worst ... Brazil and its Mercosur partners have pledged to open the bloc to more trade and investment, but changes require approval of ... Brazil is a member of the Common Market of the South (Mercosur), a trade bloc including Argentina, Paraguay, Uruguay, and ... Policies to strengthen Brazil's workforce and industrial sector, such as local content requirements, may have boosted ...
  https://www.forbes.com/places/brazil/
*  Brazil
Brazilian forced labor victims have been identified abroad.. The Government of Brazil does not fully comply with the minimum ... Some Brazilian men, and to lesser extent children, are subjected to trabalho escravo in rural areas, often on cattle ranches, ... Brazil is a destination for men, women, and children from Bolivia, Paraguay, Peru, and China in situations of trabalho escravo ... Under Brazilian law, the term trabalho escravo, or slave labor, is defined as forced labor or labor performed during exhausting ...
  https://www.state.gov/j/tip/rls/tiprpt/countries/2013/215408.htm
*  Food - Brazil
Bem-vindo ao Brasil‎ , ‎ Food In Brazil a lot of people like to eat meat because of the animals. Chicken,BBQ chiken,beef and ...
  https://sites.google.com/a/stjosephsderby.co.uk/brazil/home/food
*  Collection: Brazil
Flickr is almost certainly the best online photo management and sharing application in the world. Show off your favorite photos and videos to the world, securely and privately show content to your friends and family, or blog the photos and videos you take with a cameraphone.
  https://www.flickr.com/photos/columbiawatercenter/collections/72157623340307523/
*  Brazil
... , one of the world's largest and most populous countries. It is the largest country in South America, occupying almost ... Brazil's large size and diverse population provide great variety in the natural environment, culture, and economy. ... of the Brazilian Highlands to the south. The climate is generally tropical, but areas located at higher elevations or farther ...
  http://www.umich.edu/~isn/fest/part-brazil.html
*  Brazil
Springer - Our business is publishing. Throughout the world, we provide scientific and professional communities with superior specialist information;
  http://www.springer.com/br/
*  Brazil Blazes | WIRED
The rains came early to the Roraima region of Brazil, and what a godsend after fires raging for up to two months had burned ... Brazil Blazes. The rains came early to the Roraima region of Brazil, and what a godsend after fires raging for up to two months ...
  https://www.wired.com/1998/04/brazil-blazes/
*  IEA - Brazil
The goal of the Brazil Inova Energia Program is to boost cooperation and knowledge sharing between companies and technology ... Program is financed by National Development Bank - Banco Nacional de Desenvolvimento Economico e Social (BNDES); Brazilian ... National Development Bank - Banco Nacional de Desenvolvimento Economico e Social (BNDES); Brazilian Innovation Agency - ...
  http://www.iea.org/policiesandmeasures/pams/brazil/name-146111-en.php?s=dHlwZT1yZSZzdGF0dXM9T2s,&return=PG5hdiBpZD0iYnJlYWRjcnVtYiI-PGEgaHJlZj0iLyI-SG9tZTwvYT4gJnJhcXVvOyA8YSBocmVmPSIvcG9saWNpZXNhbmRtZWFzdXJlcy8iPlBvbGljaWVzIGFuZCBNZWFzdXJlczwvYT4gJnJhcXVvOyA8YSBocmVmPSIvcG9saWNpZXNhbmRtZWFzdXJlcy9yZW5ld2FibGVlbmVyZ3kvIj5SZW5ld2FibGUgRW5lcmd5PC9hPjwvbmF2Pg,,
*  Brazil - LA Times
From June 12 through July 13, FIFA World Cup soccer takes over the country. Unless you're crazy for it, don't go then. But before or after, you may find an exhilarating country made slightly tidier and safer (www.visitbrasil.com), from the jaw-dropping geography of Rio de Janeiro to colonial Ouro...
  http://www.latimes.com/travel/lat-places2014-wre0013191251-20131209-photo.html
*  GOE (Brazil) - Wikipedia
This article is about the Brazilian police unit. For Portuguese police unit with the same name, see Grupo de Operações ... They recently distinguished themselves by imprisoning Lebanese Citizen Rana Koleilat, who was a fugitive in Brazil. She was ... Many have worked in other tactical units and some even have served for years the Brazilian Armed Forces. ... the São Paulo GOE has established itself as one of the largest and best police special forces units in Brazil. ...
  https://en.wikipedia.org/wiki/GOE_
*  IEA - Brazil
PROCEL GEM - Municipal Energy Management collaborates with the municipal administrator, the management and efficient use of power consuming units connected to the city. Its goal is to improve the management of electricity (purchasing, maintenance, and tariff review), identify opportunities for saving energy, reducing waste, using more efficient equipment shown, and greater awareness of the efficient use of energy by users.. PROCEL GEM aims to contribute to the strengthening of municipal competence in the management of electrical energy, and energy conservation at the local level.. The actions are based on the following guidelines:. ...
  http://www.iea.org/policiesandmeasures/pams/brazil/name-30821-en.php?s=dHlwZT1jYyZzdGF0dXM9T2s,&return=PG5hdiBpZD0iYnJlYWRjcnVtYiI-PGEgaHJlZj0iLyI-SG9tZTwvYT4gJnJhcXVvOyA8YSBocmVmPSIvcG9saWNpZXNhbmRtZWFzdXJlcy8iPlBvbGljaWVzIGFuZCBNZWFzdXJlczwvYT4gJnJhcXVvOyA8YSBocmVmPSIvcG9saWNpZXNhbmRtZWFzdXJlcy9jbGltYXRlY2hhbmdlLyI-Q2xpbWF0ZSBDaGFuZ2U8L2E-PC9uYXY-

University of CampinasThreshold host density: Threshold host density (NT), in the context of wildlife disease ecology, refers to the concentration of a population of a particular organism as it relates to disease. Specifically, the threshold host density (NT) of a species refers to the minimum concentration of individuals necessary to sustain a given disease within a population.List of rivers of Brazil: This is a list of rivers in Brazil.Four Seasons Baltimore and Residences: Four Seasons Hotel Baltimore is currently a 22 story highrise hotel complex building which opened on November 14, 2011. The building's construction began back in 2007 and went through several changes.Adolfo Lutz: Adolfo Lutz (6 October 1855 – 18 December 1940) was a Brazilian physician, father of tropical medicine and medical zoology in Brazil, and a pioneer epidemiologist and researcher in infectious diseases.Peat swamp forest: Peat swamp forests are tropical moist forests where waterlogged soil prevents dead leaves and wood from fully decomposing. Over time, this creates a thick layer of acidic peat.Lampreado: thumb | 250px | right | LampreadoTheodor Bilharz Research Institute: The Theodor Bilharz Research Institute is located in Giza, Egypt.Epidemiological method: The science of epidemiology has matured significantly from the times of Hippocrates and John Snow. The techniques for gathering and analyzing epidemiological data vary depending on the type of disease being monitored but each study will have overarching similarities.

(1/13421) Use of wood stoves and risk of cancers of the upper aero-digestive tract: a case-control study.

BACKGROUND: Incidence rates for cancers of the upper aero-digestive tract in Southern Brazil are among the highest in the world. A case-control study was designed to identify the main risk factors for carcinomas of mouth, pharynx, and larynx in the region. We tested the hypothesis of whether use of wood stoves is associated with these cancers. METHODS: Information on known and potential risk factors was obtained from interviews with 784 cases and 1568 non-cancer controls. We estimated the effect of use of wood stove by conditional logistic regression, with adjustment for smoking, alcohol consumption and for other sociodemographic and dietary variables chosen as empirical confounders based on a change-in-estimate criterion. RESULTS: After extensive adjustment for all the empirical confounders the odds ratio (OR) for all upper aero-digestive tract cancers was 2.68 (95% confidence interval [CI] : 2.2-3.3). Increased risks were also seen in site-specific analyses for mouth (OR = 2.73; 95% CI: 1.8-4.2), pharyngeal (OR = 3.82; 95% CI: 2.0-7.4), and laryngeal carcinomas (OR = 2.34; 95% CI: 1.2-4.7). Significant risk elevations remained for each of the three anatomic sites and for all sites combined even after we purposefully biased the analyses towards the null hypothesis by adjusting the effect of wood stove use only for positive empirical confounders. CONCLUSIONS: The association of use of wood stoves with cancers of the upper aero-digestive tract is genuine and unlikely to result from insufficient control of confounding. Due to its high prevalence, use of wood stoves may be linked to as many as 30% of all cancers occurring in the region.  (+info)

(2/13421) A method for calculating age-weighted death proportions for comparison purposes.

OBJECTIVE: To introduce a method for calculating age-weighted death proportions (wDP) for comparison purposes. MATERIALS AND METHODS: A methodological study using secondary data from the municipality of Sao Paulo, Brazil (1980-1994) was carried out. First, deaths are weighted in terms of years of potential life lost before the age of 100 years. Then, in order to eliminate distortion of comparisons among proportions of years of potential life lost before the age of 100 years (pYPLL-100), the denominator is set to that of a standard age distribution of deaths for all causes. Conventional death proportions (DP), pYPLL-100, and wDP were calculated. RESULTS: Populations in which deaths from a particular cause occur at older ages exhibit lower wDP than those in which deaths occur at younger ages. The sum of all cause-specific wDP equals one only when the test population has exactly the same age distribution of deaths for all causes as that of the standard population. CONCLUSION: Age-weighted death proportions improve the information given by conventional DP, and are strongly recommended for comparison purposes.  (+info)

(3/13421) Chagas' disease diagnosis: comparative analysis of parasitologic, molecular, and serologic methods.

During the course of chronic chagasic infection, low parasitemia levels prevent parasite detection by current techniques such as hemoculture and xenodiagnosis. Since serologic tests have sensitivity but lack specificity, molecular assays based on the polymerase chain reaction (PCR) have been proposed as alternative tools for parasite detection in individuals with chronic Chagas' disease. A variable degree of PCR efficiency has been reported in the literature and illustrates the need for further evaluation of large numbers of chagasic patients. In this study, we compared an optimized PCR technique with hemoculture and complement-mediated lysis (CoML) in 113 individuals from or living in endemic areas of Brazil who had conventional serologic results that were either positive, negative, or inconclusive. The PCR amplification yielded positive results in 83.5% (66 of 79) of individuals with positive serology, 47.6% (10 of 21) with negative serology, and 46.2% (6 of 13) with inconclusive serology. Of 10 patients with negative serology and positive PCR result, eight (80%) had positive CoML, indicating that they could have been chagasic but were not mounting immune responses. The PCR results were also positive for all individuals who had positive hemoculture, for 37 individuals with negative hemoculture and positive serology, and for two of six individuals with inconclusive serology and negative hemoculture. Thirteen individuals living in nonendemic areas who had negative serology were used as a negative control group: 100% had negative PCR results. Our results show that the optimized PCR protocol used here was very sensitive in detecting the presence of Trypanosoma cruzi in chronic chagasic patients. The PCR and CoML results were well correlated in all of the groups studied, which suggests that our PCR protocol may be effective in the evaluation of cure in patients who receive anti-parasite treatment.  (+info)

(4/13421) Extensive cross-contamination of specimens with Mycobacterium tuberculosis in a reference laboratory.

A striking increase in the numbers of cultures positive for Mycobacterium tuberculosis was noticed in a mycobacterial reference laboratory in Campinas, Sao Paulo State, Brazil, in May 1995. A contaminated bronchoscope was the suspected cause of the increase. All 91 M. tuberculosis isolates grown from samples from patients between 8 May and 18 July 1995 were characterized by spoligotyping and IS6110 fingerprinting. Sixty-one of the 91 isolates had identical spoligotype patterns, and the pattern was arbitrarily designated S36. The 61 specimens containing these isolates had been processed and cultured in a 21-day period ending on 1 June 1995, but only 1 sample was smear positive for acid-fast bacilli. The patient from whom this sample was obtained was considered to be the index case patient and had a 4+ smear-positive lymph node aspirate that had been sent to the laboratory on 10 May. Virtually all organisms with spoligotype S36 had the same IS6110 fingerprint pattern. Extensive review of the patients' charts and investigation of laboratory procedures revealed that cross-contamination of specimens had occurred. Because the same strain was grown from all types of specimens, the bronchoscope was ruled out as the outbreak source. The most likely source of contamination was a multiple-use reagent used for specimen processing. The organism was cultured from two of the solutions 3 weeks after mock contamination. This investigation strongly supports the idea that M. tuberculosis grown from smear-negative specimens should be analyzed by rapid and reliable strain differentiation techniques, such as spoligotyping, to help rule out laboratory contamination.  (+info)

(5/13421) Dual and recombinant infections: an integral part of the HIV-1 epidemic in Brazil.

We systematically evaluated multiple and recombinant infections in an HIV-infected population selected for vaccine trials. Seventy-nine HIV-1 infected persons in a clinical cohort study in Rio de Janeiro, Brazil, were evaluated for 1 year. A combination of molecular screening assays and DNA sequencing showed 3 dual infections (3.8%), 6 recombinant infections (7.6%), and 70 (88.6%) infections involving single viral subtypes. In the three dual infections, we identified HIV-1 subtypes F and B, F and D, and B and D; in contrast, the single and recombinant infections involved only HIV-1 subtypes B and F. The recombinants had five distinct B/F mosaic patterns: Bgag-p17/Bgag-p24/Fpol/Benv, Fgag-p17/Bgag-p24/Fpol/Fenv, Bgag-p17/B-Fgag-p24/Fpol/Fenv, Bgag-p17/B-Fgag-p24/Fpol/Benv, and Fgag-p17/B-Fgag-p24/Fpol/Fenv. No association was found between dual or recombinant infections and demographic or clinical variables. These findings indicate that dual and recombinant infections are emerging as an integral part of the HIV/AIDS epidemic in Brazil and emphasize the heterogenous character of epidemics emerging in countries where multiple viral subtypes coexist.  (+info)

(6/13421) Integrating homoeopathy in health systems.

Homoeopathy is a therapy which involves many components and three main agents: the patient, with his or her condition and personal characteristics; the medication used, with its composition and manufacturing procedure; and the physician, with his or her approach to treatment and concepts of health. The development of research and evaluation structures, combined with a critical education in the discipline, would help to improve practices and define homoeopathy's potential role in relation to the other therapies, both conventional and unconventional, used in Western health systems.  (+info)

(7/13421) Full results of the genome-wide scan which localises a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33.

Three hundred million individuals are at risk of infection by schistosomes, and thousands die each year of severe hepatic disease. Previous studies have shown that the intensity of infection by Schistosoma mansoni in a Brazilian population is controlled by a major gene, denoted as SM1. We report here the full results of a genome-wide search that was performed on this population to localise SM1. Two hundred and forty-six microsatellites were used for the primary map, and only one region in 5q31-q33 provided significant evidence of linkage. SM1 was subsequently mapped to this region, which contains several genes encoding cytokines or cytokine receptors which are involved in protection against schistosomes. Three additional regions, 1p22.2, 7q36 and 21q22-22-qter, yielded promising, although not significant, lod-score values. These regions contain candidate genes encoding cytokines or molecules relevant to anti-schistosome immunity.  (+info)

(8/13421) Familial clustering of diabetic nephropathy in Brazilian type 2 diabetic patients.

There is evidence for genetic predisposition to diabetic nephropathy in type 1 diabetic patients. However, there are few studies on type 2 diabetic patients, and most of those have been conducted on ethnic minorities or Caucasian individuals. The aim of this study was to ascertain the presence of an inherited predisposition to diabetic nephropathy in a sample of Brazilian type 2 diabetic patients. Families with two or more type 2 diabetic siblings were identified. Subjects with the longest duration of known diabetes were considered probands. Some 90 probands and their 107 diabetic siblings were studied. Urinary albumin excretion rate was measured in a sterile 24-h urine sample on at least three different occasions. Probands and siblings were classified according to urinary albumin excretion rate as normo- (<20 microg/min), micro- (20-200 microg/min), or macroalbuminuric (>200 microg/min). Patients with end-stage renal disease were included in the macroalbuminuric group. Macroalbuminuria was identified in 5.2% of the siblings of normoalbuminuric probands and in 24.1% of the siblings of macroalbuminuric probands (P = 0.024). In multiple logistic regression, the presence of diabetic nephropathy in probands (micro- or macroalbuminuria and end-stage renal disease) was significantly associated with the presence of sibling diabetic nephropathy (odds ratio = 3.75, 95% CI = 1.36-10.40, P = 0.011) adjusted for proband fasting plasma glucose and diabetes duration. Interpretation of these results should take into account the possibility that the families including siblings with diabetic nephropathy may have been overcounted and, on the other hand, that the siblings without diabetic nephropathy may have been undercounted. In conclusion, there is a familial aggregation of diabetic nephropathy in this sample of type 2 diabetic patients.  (+info)