Thyroxine-Binding Proteins: Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.Thyroxine-Binding Globulin: A thyroid hormone transport protein found in serum. It binds about 75% of circulating THYROXINE and 70% of circulating TRIIODOTHYRONINE.Serum Globulins: All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.Norethandrolone: A synthetic hormone with anabolic and androgenic properties and moderate progestational activity.Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.Thyroid Function Tests: Blood tests used to evaluate the functioning of the thyroid gland.Blood Protein DisordersHypoproteinemia: A condition in which total serum protein level is below the normal range. Hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, EDEMA, or PROTEINURIA.Iodine Isotopes: Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.Blood Protein Electrophoresis: Electrophoresis applied to BLOOD PROTEINS.Alpha-Globulins: Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.Hyperthyroidism: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.Thyronines: A group of metabolites derived from THYROXINE and TRIIODOTHYRONINE via the peripheral enzymatic removal of iodines from the thyroxine nucleus. Thyronine is the thyroxine nucleus devoid of its four iodine atoms.Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.Prealbumin: A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease.Triiodothyronine, Reverse: A metabolite of THYROXINE, formed by the peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus.Thyrotropin: A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.Transcortin: A serpin family member that binds to and transports GLUCOCORTICOIDS in the BLOOD.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.GlobulinsThyroid Hormones: Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Dialysis: A process of selective diffusion through a membrane. It is usually used to separate low-molecular-weight solutes which diffuse through the membrane from the colloidal and high-molecular-weight solutes which do not. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Thyroid Diseases: Pathological processes involving the THYROID GLAND.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Immunodiffusion: Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.Sex Hormone-Binding Globulin: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Deficiency Diseases: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)gamma-Globulins: Serum globulins that migrate to the gamma region (most positively charged) upon ELECTROPHORESIS. At one time, gamma-globulins came to be used as a synonym for immunoglobulins since most immunoglobulins are gamma globulins and conversely most gamma globulins are immunoglobulins. But since some immunoglobulins exhibit an alpha or beta electrophoretic mobility, that usage is in decline.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Kinetics: The rate dynamics in chemical or physical systems.

*  Thyroxine-binding Globulin Medical Definition | Merriam-Webster Medical Dictionary
... a blood serum glycoprotein that is synthesized in the liver and that binds tightly to thyroxine and… ... medical Definition of thyroxine-binding globulin. : a blood serum glycoprotein that is synthesized in the liver and that binds ... What made you want to look up thyroxine-binding globulin? Please tell us where you read or heard it (including the quote, if ... tightly to thyroxine and less firmly to triiodothyronine preventing their removal from the blood by the kidneys and releasing ...
  https://www.merriam-webster.com/medical/thyroxine-binding%20globulin
*  Partial Purification of Rat Serum Thyroxine-Binding Globulin | SpringerLink
... but their serum-binding proteins for thyroid hormones (TH) remain unclear compared with those of human beings.... ... 2) reported the presence of rat serum thyroxine-binding globulin (R-TBG) using polyacrylamide gel slab electrophoresis, but ... 1986) Partial Purification of Rat Serum Thyroxine-Binding Globulin. In: Medeiros-Neto G., Gaitan E. (eds) Frontiers in ... Binding Characteristic High Carbohydrate Diet Relative Affinity Maximal Binding Capacity Charcoal Adsorption These keywords ...
  https://link.springer.com/chapter/10.1007/978-1-4684-5260-0_85
*  Thyroxine-Binding Globulin: Specificity for the Hormonally Active Conformation of Triiodothyronine | Science
The lower binding affinity of thyroxine-binding globulin for triiodothyronine as compared to thyroxine may be explained by ... The conformational requirements for binding of triiodothyronine to thyroxine-binding globulin were investigated with ... iodine is more effective in displacing triiodothyronine and thyroxine from thyroxine-binding globulin. ... Thyroxine-Binding Globulin: Specificity for the Hormonally Active Conformation of Triiodothyronine Message Subject. (Your Name ...
  http://science.sciencemag.org/content/178/4057/172
*  Health Article - Serum Thyroxine-Binding Globulin (TBG) Level Test - AARP
Most of the protein-bound T3 and T4 in your body bind to thyroxine-binding globulin (TBG). The serum TBG level test measures ... Most of the T3 and T4 in your body binds with proteins produced by your body. The small amounts of T3 and T4 that don't bind ...
  http://healthtools.aarp.org/health/serum-tbg-level
*  Thyroxine Binding Globulin and Thyroid Function Tests in Patients with Hepatocellular Carcinoma - Kalk - 1982 - Hepatology -...
Impaired binding properties of thyroxine-binding globulin in hepatocellular carcinoma and chronic liver disease, Hepatology, ... Differential hormone-binding characteristics of thyroxine-binding globulin in hepatocellular carcinoma and cirrhosis, Journal ... Thyroxine Binding Globulin and Thyroid Function Tests in Patients with Hepatocellular Carcinoma. Authors. *. W. John Kalk,. * ... Luigi Bartalena, Studies on thyroxine-binding globulin, Journal of Endocrinological Investigation, 1993, 16, 5, 353. CrossRef ...
  http://onlinelibrary.wiley.com/doi/10.1002/hep.1840020112/abstract
*  Thyroxine-binding globulin - Wikipedia
Thyroxine-binding globulin (TBG) is a globulin that binds thyroid hormones in circulation. It is one of three transport ... "Complete deficiency of thyroxine-binding globulin (TBG-CD Buffalo) caused by a new nonsense mutation in the thyroxine-binding ... Thyroxine-binding globulin tests are sometimes used to find the cause of raised or lowered levels of thyroid hormone. This is ... 1991). "Complete thyroxine-binding globulin (TBG) deficiency caused by a single nucleotide deletion in the TBG gene". Metab. ...
  https://en.wikipedia.org/wiki/Thyroxine-binding_globulin
*  Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis | Biochemical...
Thyroxine-binding globulin (TBG) and corticosteroid-binding globulin are unique among non-inhibitory members of the superfamily ... corticosteroid-binding globulin; HLE, human leucocyte elastase; Ka, affinity constant [thyroxine (T4)-binding]; α1-PI, α1- ... Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis. Helmut ... Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis ...
  http://www.biochemj.org/content/365/1/311
*  Thyroxine-binding globulin | Article about Thyroxine-binding globulin by The Free Dictionary
Find out information about Thyroxine-binding globulin. any of a large family of proteins protein, any of the group of highly ... complex organic compounds found in all living cells and comprising the most abundant... Explanation of Thyroxine-binding ... globulin. (redirected from Thyroxine-binding globulin). Also found in: Dictionary, Thesaurus, Medical, Wikipedia. globulin,. ... Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs.. ...
  https://encyclopedia2.thefreedictionary.com/Thyroxine-binding+globulin
*  Thyroxine-binding globulin
Explanation for the high heat stability of thyroxine binding globulin-Chicago.. 19838169. 2009. Enrichment of glycopeptides for ... The allosteric modulation of thyroxine-binding globulin affinity is entropy driven.. 23376485. 2013. Proteomic analysis of ... Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern ... Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.. 20429632. Freshly isolated TBG- ...
  https://pharos.nih.gov/idg/targets/P05543
*  The International Standard for Thyroxine Binding Globulin
The International Standard for Thyroxine Binding Globulin Bristow, A. F. 관련메뉴. ; Gaines-Das, R. E. 관련메뉴. ; Buttress, N. 관련메뉴. ...
  http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART00106818
*  AndroGel 1.62 (Testosterone Gel): Side Effects, Interactions, Warning, Dosage & Uses
Decreased Thyroxine-binding Globulin. Androgens, including AndroGel 1.62%, may decrease concentrations of thyroxin-binding ... Circulating testosterone is primarily bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Approximately 40% ... of testosterone in plasma is bound to SHBG, 2% remains unbound (free) and the rest is loosely bound to albumin and other ... globulins, resulting in decreased total T4 serum concentrations and increased resin uptake of T3 and T4. Free thyroid hormone ...
  https://www.rxlist.com/androgel-162-drug.htm
*  Testim - FDA prescribing information, side effects and uses
Decreased Thyroxine-binding Globulin. Androgens, including Testim, may decrease concentrations of thyroxine-binding globulins, ... Circulating testosterone is primarily bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Approximately 40% ... of testosterone in plasma is bound to SHBG, 2% remains unbound (free) and the rest is loosely bound to albumin and other ...
  https://www.drugs.com/pro/testim.html
*  Fortesta Gel - FDA prescribing information, side effects and uses
5.15 Decreased Thyroxine-binding globulin. Androgens, including FORTESTA, may decrease concentrations of thyroxin-binding ... Circulating testosterone is primarily bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Approximately 40% ... Additionally, there were no clinically significant changes from baseline for sex hormone binding globulin (SHBG) (slight ... of testosterone in plasma is bound to SHBG, 2% remains unbound (free) and the rest is loosely bound to albumin and other ...
  https://www.drugs.com/pro/fortesta-gel.html
*  Patent US20060249381 - Cellulosic-based resistance domain for an analyte sensor - Google Patents
... thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I ... Binding acceleration techniques for the detection of analytes. US20050031689 *. May 10, 2004. Feb 10, 2005. Dexcom, Inc.. ... Binding acceleration techniques for the detection of analytes. US6343225 *. Sep 14, 1999. Jan 29, 2002. Implanted Biosystems, ... While not wishing to be bound by theory, it is believed that a fast dip rate as described above advantageously provides the ...
  http://www.google.com/patents/US20060249381?dq=6,304,975
*  Patent US4540573 - Undenatured virus-free biologically active protein derivatives - Google Patents
... thyroxine binding globulin, serum esterase, alkaline phosphates, alpha1 -acid glycoprotein, factor II, factor VII, factor VIII ... alpha-globulins, beta-globulins, gamma-globulins (immune serum globulins), the coagulation proteins (antithrombin III, ... thyroxine binding globulin; serum esterase; alpha.sub.1 -lipoprotein; albumin; alkaline phosphataseV albumin; alpha-globulinVI ... alpha-globulins, beta-globulins, gamma-globulins, factor III, the complement components, fibronectin, antithrombin III, ...
  http://www.google.ca/patents/US4540573
*  Patent US20060020189 - Transcutaneous analyte sensor - Google Patents
... thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I ... While not wishing to be bound by theory, it is believed that by providing an exit port for the sensor 32 located away from the ... While not wishing to be bound by theory, it is believed that ventilation to the exit-site (or to the sensor 32) can reduce or ... While not wishing to be bound by theory, it is believed that a slight friction fit of the sensor within the needle minimizes ...
  http://www.google.com/patents/US20060020189?dq=5311516
*  Patent US20100185073 - System and methods for processing analyte sensor data - Google Patents
... thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I ... free thyroxine (FT4); free tri-iodothyronine (FT3); fumarylacetoacetase; galactose/gal-1-phosphate; galactose-1-phosphate ...
  http://www.google.com/patents/US20100185073?dq=6,957,233
*  Patente US20050031689 - Biointerface membranes incorporating bioactive agents - Google Patentes
... thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I ... While not wishing to be bound by any particular theory, it is believed that this loss of function is due to the lack of direct ... While not wishing to be bound by theory, it is believed that Dexamethasone released over time can modify a tissue response to ... While not wishing to be bound by theory, it is believed that formation of high tissue granulation induces blood vessels, which ...
  http://www.google.es/patents/US20050031689
*  Patent US20050143635 - Calibration techniques for a continuous analyte sensor - Google Patents
... thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I ... While not wishing to be bound by theory, it is believed that by determining a stability of the analyte sensor based on a co- ... While not wishing to be bound by theory, it is believed that shifts in baseline may also correlate and/or be related to changes ... While not wishing to be bound by theory, it is believed that in some embodiments, the sensitivity m of the calibration of the ...
  http://www.google.com.au/patents/US20050143635
*  Quantitative proteomic study of the plasma reveals acute phase response and LXR/RXR and FXR/RXR activation in the chronic...
Thyroxine-binding globulin. 12. 1.61. 4.15E-03. Q60590. ORM1. α-1-acid glycoprotein 1. 6. 1.62. 1.81E-03. ... Brănescu C, Şerban D, Şavlovschi C, Dascălu AM and Kraft A: Lipopolysaccharide binding protein (L.B.P.)-an inflammatory marker ... Ding PH and Jin LJ: The role of lipopolysaccharide-binding protein in innate immunity: A revisit and its relevance to oral/ ... Ren L, Jiang ZQ, Fu Y, Leung WK and Jin L: The interplay of lipopolysaccharide-binding protein and cytokines in periodontal ...
  https://www.spandidos-publications.com/mmr/17/1/93
*  Liothyronine - DrugBank
L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the ... Thyroxine-binding globulin. Molecular Weight. 46324.12 Da. References. *Palha JA: Transthyretin as a thyroid hormone carrier: ... Identical protein binding. Specific Function. Thyroid hormone-binding protein. Probably transports thyroxine from the ... iodothyronine, iodophenol, 2-halophenol (CHEBI:18258) / thyroxine, Other amino acids (C02465) Targets. Binding Properties. ×. ...
  https://www.drugbank.ca/drugs/DB00279
*  Application # 2005/0056552. Increasing bias for oxygen production in an electrode system - Patents.com
... thyroxine (T4); thyroxine-binding globulin; trace elements; transferrin; UDP-galactose-4-epimerase; urea; uroporphyrinogen I ... free thyroxine (FT4); free tri-iodothyronine (FT3); fumarylacetoacetase; galactose/gal-1-phosphate; galactose-1-phosphate ...
  http://patents.com/us-20050056552.html
*  Duavee (combination) Monograph for Professionals - Drugs.com
Estrogen therapy increases thyroxine-binding globulin (TBG) concentrations.1 Bazedoxifene/conjugated estrogens in fixed ... corticosteroid-binding globulin [CBG], sex hormone binding globulin [SHBG]) leading to increased total circulating ... Plasma Protein Binding. Highly bound (98-99%);1 does not bind to SHBG.1 ... Binds to estrogen receptor (ER) α and ERβ;1 11 25 slightly stronger binding occurs at ERα receptor.20 24 ...
  https://www.drugs.com/monograph/duavee-combination.html
*  anti-serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 7 Primary Antibodies
... thyroxine-binding globulin , thyroxin-binding globulin , serine (or cysteine) peptidase inhibitor, clade A (alpha-1 ... Two novel variants in the thyroxine-binding globulin gene behind the diagnosis of TBG deficiency. homozygous. One involved ... polymorphism in exon 2 in thyroxine-binding globulin is a candidate for the causative variation affecting testis size in boars ... Human Monoclonal SERPINA7 Primary Antibody for ICC, FACS - ABIN1724894 : Yan, Yan, Ou: Human thyroxine binding globulin (TBG) ...
  https://www.antibodies-online.com/hormone-transport-pathway-38/serpina7-antibody-17502/

Squash at the Pan American Games: Mar del PlataReverse triiodothyronineDeracoxibSerum protein electrophoresisInter-alpha-trypsin inhibitor: Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1, ITIH2, ITIH3, ITIH4 and one light chain selected from the group AMBP or SPINT2. They function as protease inhibitors.HyperthyroidismRO5166017: RO-5166017 is a drug developed by Hoffmann-La Roche which acts as a potent and selective agonist for the trace amine-associated receptor 1, with no significant activity at other targets. This is important for the study of the TAAR1 receptor, as while numerous other compounds are known which act as TAAR1 agonists, such as methamphetamine, MDMA and 3-iodothyronamine, all previously known TAAR1 agonists are either weak and rapidly metabolized (endogenous ligands), or have strong pharmacological activity at other targets (amphetamines, thyronamines), making it very difficult to assess which effects are due to TAAR1 activation.HypothyroidismTransthyretin: Transthyretin (TTR) is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol-binding protein bound to retinol. This is how transthyretin gained its name, transports thyroxine and retinol.Thyrotropic cellTranscortin: Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-globulin.Globulin: The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but soluble in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune system.Thyroid hormone: The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. T3 and T4 are partially composed of iodine (see molecular model).Bisalbuminemia: Bisalbuminemia is the, sometimes inherited, condition of having two types of serum albumin that differ in mobility during electrophoresis. It can be seen in densitometry as a bifid mountain where albumin has 2 heads.Dialysis (biochemistry): In biochemistry, dialysis is the process of separating molecules in solution by the difference in their rates of diffusion through a semipermeable membrane, such as dialysis tubing.Follicular cellRadial immunodiffusion: Radial immunodiffusion (RID) or Mancini method, Mancini immunodiffusion or single radial immunodiffusion assay, is an immunodiffusion technique used in immunology to determine the quantity or concentration of an antigen in a sample. Antibody is incorporated into a medium such as an agar gel.Pedigree chart: A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next,pedigree chart Genealogy Glossary - About.com, a part of The New York Times Company.Proximity ligation assay: Proximity ligation assay (in situ PLA) is a technology that extends the capabilities of traditional immunoassays to include direct detection of proteins, protein interactions and modifications with high specificity and sensitivity. Protein targets can be readily detected and localized with single molecule resolution and objectively quantified in unmodified cells and tissues.Symmetry element: A symmetry element is a point of reference about which symmetry operations can take place. In particular, symmetry elements can be centers of inversion, axes of rotation and mirror planes.Burst kinetics: Burst kinetics is a form of enzyme kinetics that refers to an initial high velocity of enzymatic turnover when adding enzyme to substrate. This initial period of high velocity product formation is referred to as the "Burst Phase".

(1/15) Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma.

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(2/15) Inverse log-linear relationship between thyroid-stimulating hormone and free thyroxine measured by direct analog immunoassay and tandem mass spectrometry.

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(3/15) Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.

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(4/15) Thyroid dysfunction as a mediator of organochlorine neurotoxicity in preschool children.

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(5/15) Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.

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(6/15) Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17beta-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function.

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(7/15) Thyroid function during controlled ovarian hyperstimulation as part of in vitro fertilization.

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(8/15) Thyroid hormone metabolism and environmental chemical exposure.

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  • hypothyroid
  • We report that R-TBG was partially purified using Sephadex G-200 gel filtration from hypothyroid rat serum and its binding characteristics determined by charcoal-binding method. (springer.com)
  • So, for instance, if the patient is truly hypothyroid, and TBG levels are normal, then there are many sites open for binding on the TBG, since the total thyroid hormone level is low. (wikipedia.org)
  • concentrations
  • To determine the prevalence of elevated serum concentrations of thyroxine binding globulin (TBG) in patients with hepatocellular carcinoma (HCC) and the influence of the associated cirrhosis, TBG was measured in 39 patients with HCC, 22 with and 17 without cirrhosis, in 20 patients with cryptogenic macronodular cirrhosis but without HCC, and in 40 matched controls. (wiley.com)
  • inhibitor
  • To define the mechanism that leads to disruption of hormone binding of TBG after proteolytic cleavage, the effect of partial loop deletions and replacements by the α 1 -proteinase inhibitor homologues of TBG were evaluated. (biochemj.org)
  • Thus
  • Thus, R-TBG has not yet been purified, and its binding characteristics have not been determined. (springer.com)
  • It is found in the mucosa and binds iron, thus creating an environment low in free iron that impedes bacterial survival in a process called iron withholding. (wikipedia.org)
  • liver
  • The mechanism of activating the promoter for SHBG in the liver involves hepatocyte nuclear factor 4 alpha (HNF4A) binding to a DR1 like cis element which then stimulate production. (wikipedia.org)
  • pregnancy
  • Fetal thyroxine is wholly obtained from maternal sources in early pregnancy since the fetal thyroid gland only becomes functional in the second trimester of gestation. (wikipedia.org)
  • total
  • The total T4 is less accurate due to the large amount of T4 that is bound. (wikipedia.org)
  • The total T3 is measured in clinical practice since the T3 has decreased amount that is bound as compared to T4. (wikipedia.org)
  • increase
  • Such drastic increase in mRNA will increase the proportion of Tau containing four microtubule-binding repeats, which is consistent with the neuropathology described in several families with FTDP-17, a type inherited dementia. (wikipedia.org)
  • mechanism
  • This contrasts with the more common competitive mechanism for protease inhibitors that bind to and block access to the protease active site. (wikipedia.org)
  • site
  • The N- and C- terminal sequences are represented by globular lobes and between the two lobes is an iron-binding site. (wikipedia.org)
  • activity
  • Proteolytic cleavage of this variant revealed an intact S→R transition and reduced its binding activity to that of cleaved TBG. (biochemj.org)