Thyrotropin Alfa: A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.Ablation Techniques: Removal of tissue by vaporization, abrasion, or destruction. Methods used include heating tissue by hot liquids or microwave thermal heating, freezing (CRYOABLATION), chemical ablation, and photoablation with LASERS.Thyrotropin: A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.Receptors, Thyrotropin: Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).Thyroid Gland: A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.Thyrotropin-Releasing Hormone: A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.

*  DMOZ - Health: Pharmacy: Drugs and Medications: T: Thyrotropin
Thyrogen - (thyrotropin alfa) - Genzyme Official pharmaceutical website (thyrotropin alfa for injection) is used in combination ...
  http://dmoztools.net/Health/Pharmacy/Drugs_and_Medications/T/Thyrotropin/
*  Thyrogen 0,9 mg prašak za otopinu za injekciju - Mediately Baza Lijekova
thyrotropin alfa, Prašak za otopinu za injekciju, ATC H01AB01, SmPC (Sažetak opisa svojstava lijeka) Terapijske indikacije: ...
  https://mediately.co/hr/drugs/2XNnAtbiIzc1kxcf6dKLdCPXxjb/thyrogen-0-9-mg-prasak-za-otopinu-za-injekciju
*  Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer - Full Text View - ClinicalTrials.gov
... thyrotropin alfa for injection) will be more sensitive for the detection of disease sites than PET-CT scanning without rTSH. ... Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer. The recruitment status of this study is unknown. The ... Chin BB, Patel P, Cohade C, Ewertz M, Wahl R, Ladenson P. Recombinant human thyrotropin stimulation of fluoro-D-glucose ... Utility of Recombinant Human Thyrotropin (rTSH) PET-CT Fusion Scanning to Identify Residual Well-Differentiated Epithelial ...
  https://clinicaltrials.gov/ct2/show/NCT00181168
*  Thyrogen Dosage Guide - Drugs.com
... thyrotropin alfa). Includes dose adjustments, warnings and precautions. ... Withdraw 1 mL of the reconstituted THYROGEN solution (0.9 mg of thyrotropin alfa) and inject intramuscularly in the buttocks. ... Generic name: THYROTROPIN ALFA 0.9mg in 1mL. Dosage form: injection, powder, for solution ... The reconstituted THYROGEN solution has a concentration of 0.9 mg of thyrotropin alfa per mL. ...
  https://www.drugs.com/dosage/thyrogen.html
*  RefEx - thyroid stimulating hormone, beta
TSHB, TSH-BETA, TSH-beta, Thyrotropin subunit beta precursor, Thyroid-stimulating hormone subunit beta, Thyrotropin alfa, ...
  http://refex.dbcls.jp/gene_info.php?lang=en&db=human&geneID=7252&refseq=NM_000549&unigene=Hs.406687&probe=214529_at
*  Thyrotropin Alfa Coupon 2018 & 80% off Thyrogen Discount Card · RX24 Drugs
... on your medication with Thyrotropin Alfa Coupon from RX24 Drugs. Print a free savings card , present it to your pharmacy , ... Thyrotropin Alfa mechanism of action. Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells ... What is Thyrotropin Alfa. Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain ... We offer free Thyrotropin Alfa coupons and discounts that may help you save up to 80% off the retail price in your local ...
  https://rx24drugs.com/coupon/thyrotropin-alfa-prescription/
*  A-Z Drug Index for Prescription and OTC Medications - Alphabet T
Thyrotropin Alfa Thyrotropin Alfa is a recombinant human thyroid-stimulating hormone (TSH), used as an adjunctive diagnostic ... Taliglucerase Alfa Taliglucerase Alfa is an enzyme, prescribed for Type 1 Gaucher disease. ...
  http://www.medindia.net/doctors/drug_information/home.asp?alpha=T
*  Glucagon-like peptide-2 - Wikipedia
Agonists: Thyrotropin alfa. *TSH (thyrotropin). Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55- ...
  https://en.wikipedia.org/wiki/Glucagon-like_peptide_2
*  Telcagepant - Wikipedia
Agonists: Thyrotropin alfa. *TSH (thyrotropin). Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55- ...
  https://en.wikipedia.org/wiki/Telcagepant
*  Galanin receptor 1 - Wikipedia
Agonists: Thyrotropin alfa. *TSH (thyrotropin). Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55- ...
  https://en.wikipedia.org/wiki/Galanin_receptor_1
*  Cholecystokinin B receptor - Wikipedia
Agonists: Thyrotropin alfa. *TSH (thyrotropin). Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55- ...
  https://en.wikipedia.org/wiki/Cholecystokinin_B_receptor
*  Gonadotropin preparations - Wikipedia
Follitropin alfa. Generic Follitropin alfa injection. Brands. Gonal-f. Cinnal-f. Fertilex. Ovaleap. Bemfola. Follitropin beta. ... choriogonadotropin alfa for injection (recombinant human Chorionic Gonadotropin, r-hCG).. Brands Ovidrel. References[edit]. *^ ... lutropin alfa for injection. Brands Luveris. hCG (human Chorionic Gonadotropin) preparations[edit]. Used to induce final ... Corifollitropin alfa. Merck received approval on February 15, 2010 from the European Commission for ELONVA (corifollitropin ...
  https://en.wikipedia.org/wiki/Gonadotropin_Preparations
*  Parathyroid hormone-related protein - Wikipedia
Agonists: Thyrotropin alfa. *TSH (thyrotropin). Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55- ...
  https://en.wikipedia.org/wiki/Parathyroid_hormone-related_protein
*  Should You Take Brand Name or Generic Thyroid Drugs? | HealthCentral
Thyrotropin alfa: The drug thyrotropin alfa, used as part of monitoring tests in thyroid cancer patients, is currently under ...
  https://www.healthcentral.com/article/brand-name-vs-generic-thyroid-medications
*  Genzyme Delivers Strong Fourth Quarter to Conclude Outsta... ( Reaffirms Outlook ...)
thyrotropin alfa for injection). -- Reported highly encouraging clinical trial results for two key late ... reflects the U.S. introduction of Myozyme(R) (alglucosidase alfa),. which has been constrained by limited product supply, as ...
  http://www.bio-medicine.org/medicine-news-1/Genzyme-Delivers-Strong-Fourth-Quarter-to-Conclude-Outstanding-Year-11775-1/
*  Drugs beginning with the letter T - MedBroadcast.com
thyrotropin alfa (Thyrogen) * Tiamol (fluocinonide topical) * tiaprofenic acid (Apo-Tiaprofenic, Dom-Tiaprofenic, Nu- ...
  https://medbroadcast.com/drug/getalphalist/t
*  Chemical Structure Classification - DrugBank
Thyrotropin Alfa. Organic Compounds. Organic Acids. Carboxylic Acids and Derivatives. Amino Acids, Peptides, and Analogues. ... Dornase alfa. Organic Compounds. Organic Acids. Carboxylic Acids and Derivatives. Amino Acids, Peptides, and Analogues. Details ... Interferon alfa-n1. Organic Compounds. Organic Acids. Carboxylic Acids and Derivatives. Amino Acids, Peptides, and Analogues. ... Interferon alfa-n3. Organic Compounds. Organic Acids. Carboxylic Acids and Derivatives. Amino Acids, Peptides, and Analogues. ...
  https://www.drugbank.ca/classyfication
*  THYROGEN Prescription Assistance Programs | PharmacyChecker.com
Thyrogen injection (thyrotropin alfa). Eligibility Requirements Insurance Status Must have no prescription coverage or been ...
  https://www.pharmacychecker.com/patient-assistance-programs/thyrogen
*  Outpatient Infusion Suite - Appalachian Regional Healthcare System
Epoetin Alfa. Fingolimod Ferric Carboxymaltose. Ferumoxytol. Furosemide lnfliximab IVIG Immune Globulin. Iron Sucrose. ...
  https://www.apprhs.org/services/outpatient-infusion-suite
*  Study of BMS-650032 With Peginterferon Alfa-2a Plus Ribavirin
Thyrotropin Alfa. A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant ... The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. ... Interferon Alfa-2c. A recombinant alfa interferon consisting of 165 amino acids with arginine at positions 23 and 34. It is ... Interferon Alfa-2a. A recombinant alfa interferon consisting of 165 amino acids with lysine at position 23 and histidine at ...
  https://www.bioportfolio.com/resources/trial/69925/Study-of-BMS-650032-With-Peginterferon-Alfa-2a-Plus-Ribavirin.html
*  Thyrogen Side Effects
THYROTROPIN ALFA. Strength(s). 0.9. Unit(s). mg/mL. Pharma Class. Thyroid Stimulating Hormone [EPC],Thyrotropin [Chemical/ ...
  http://www.patientsville.com/medication/thyrogen_side_effects.htm
*  Dictionary of Cancer Terms
thyrotropin alfa (THY-roh-TROH-pin AL-fuh) listen A form of thyroid-stimulating hormone (TSH) that is made in the laboratory. ...
  https://www.cancer.gov/Common/PopUps/popDefinition.aspx?id=CDR0000386234&version=Patient&language=English
*  Clofarabine | definition of clofarabine by Medical dictionary
Medications: Clofarabine, Thyrotropin Alfa, Anti-Immunoglobulin timocitica, Plerixafor, Imigluceras.. Supply of Pharmaceutical ...
  https://medical-dictionary.thefreedictionary.com/clofarabine
*  C57BL/6 Origin Harlan Laboratories
Levy RP, McGuire WL, Shaw RK, Bartsch GE (1965) Effect of species differences of mice on the bioassay of thyrotropin. ... Specht CG, Schoepfer R (2001) Deletion of the alfa-synuclein locus in a subpopulation of C57BL/6J mice. BioMed Central ... Low sensitivity to thyrotropin (Levy et al, 1965). High brain sulphatide (Sampugna et al, 1975). High hepatic benz (alpha) ...
  http://spotidoc.com/doc/20606/c57bl-6-origin-harlan-laboratories

(1/6) TSH-induced gene expression involves regulation of self-renewal and differentiation-related genes in human bone marrow-derived mesenchymal stem cells.

 (+info)

(2/6) Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer.

 (+info)

(3/6) Increasing the yield of recombinant thyroid-stimulating hormone-stimulated 2-(18-fluoride)-flu-2-deoxy-D-glucose positron emission tomography-CT in patients with differentiated thyroid carcinoma.

 (+info)

(4/6) Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.

 (+info)

(5/6) Unexpected symptoms after rhTSH administration due to occult thyroid carcinoma metastasis.

(1)(8)F-fluorodeoxyglucose positron emission tomography ((1)(8)FDG-PET) scintigraphy is a useful imaging technique in the evaluation of metastasised thyroid carcinoma. Administration of recombinant human thyrotropin (rhTSH, Thyrogen(R)) increases the diagnostic yield of this procedure. Here we present a 64-year-old male who was followed for Hurthle cell carcinoma of the thyroid with several intrapulmonary metastases. He developed sudden complaints of neck pain following rhTSH administration as part of the routine preparation for a diagnostic (1)(8)FDG-PET/CT procedure. This investigation subsequently revealed a previously undetected metastatic lesion in the first cervical vertebra, with no signs of spinal cord compression. Treatment with a nonsteroidal anti-inflammatory drug reduced the symptoms sufficiently, and a few weeks later the neurosurgeon performed a complete resection of the metastasis. It is likely that the symptoms were caused by oedema and/or increased blood flow to the lesion. Physicians should be aware that rhTSH administration to patients with disseminated thyroid carcinoma may lead to sudden onset of symptoms caused by previously occult metastases.  (+info)

(6/6) Recombinant human thyroid-stimulating hormone in radioiodine thyroid remnant ablation.

BACKGROUND: To prevent the unwarranted effects of post-thyroidectomy hypothyroidism prior to radiodine (RAI) ablation, patients with well-differentiated thyroid cancer can currently undergo this treatment while in a euthyroid state. This is achieved with the use of recombinant human thyroid-stimulating hormone (rhTSH) injections prior to the ablation. OBJECTIVES: To demonstrate the efficacy of rhTSH in radioiodine thyroid ablation in patients with differentiated thyroid cancer. METHODS: We conducted a retrospective study of patients who underwent total thyroidectomy for well-differentiated thyroid cancer with different levels of risk, treated with rhTSH prior to remnant ablation with radioiodine. RESULTS: Seventeen patients with thyroid cancer were studied and followed fora median of 25 months (range 8-49 months). Ablation (defined as stimulated thyroglobulin < 1 mg/ml and negative neck ultrasonography) was successful in 15 patients (88.2%). One of the patients was lost to follow-up. CONCLUSIONS: The use of rhTSH with postoperative radioiodine ablation may be an efficient tool for sufficient thyroid remnant ablation, avoiding hypothyroidal state in the management of thyroid cancer patients.  (+info)



  • Injection
  • Merck received approval on February 15, 2010 from the European Commission for ELONVA (corifollitropin alfa) a long lasting single injection fusion protein lacking LH activity. (wikipedia.org)
  • Form
  • However, a more recent study showed there may be a slight clinical difference, with the alfa form tending towards a higher pregnancy rate and the beta form tending towards a lower pregnancy rate, but with significantly higher estradiol (E2) levels. (wikipedia.org)
  • tests
  • The package insert for Gonal-F states that based on physio-chemical tests and bioassays that follitropin beta and follitropin alfa are indistinguishable. (wikipedia.org)