*  What are the key factor's in knowing whether or not I have raynaud's disease? - Answered by top doctors on HealthTap
What organ system (s) are impacted by raynaud's disease? * I've heard lots of different names for raynaud's - disease, ... What organ system (s) are impacted by raynaud's disease? * I've heard lots of different names for raynaud's - disease, ... "raynaud's disease". If an underlying condition is found, then the disorder is called "raynaud's syndrome". ... What are the key factor's in knowing whether or not I have raynaud's disease? ...
  https://www.healthtap.com/user_questions/32285-what-are-the-key-factor-s-in-knowing-whether-or-not-i-have-raynaud-s-disease
*  Scleroderma Treatment & Management: Approach Considerations, Pruritus, Raynaud Phenomenon
... and it is used to describe a disease characterized by progressive skin hardening and induration. Hippocrates first described ... Raynaud Phenomenon. Raynaud phenomenon can be treated with the following agents [45, 46, 163] :. * Calcium channel blockers ( ... Raynaud phenomenon and the vascular disease in scleroderma. Curr Opin Rheumatol. 2004 Nov. 16(6):718-22. [Medline]. ... Current concepts in disease-modifying therapy for systemic sclerosis-associated interstitial lung disease: lessons from ...
  https://emedicine.medscape.com/article/331864-treatment
*  Raynaud may be more common in women of childbearing age
Raynaud's phenomenon has several warning signs, which may be present at the onset of disease. These include:. *Fingers, toes, ... While there is no known cure for Raynaud's phenomenon, people with the disease are usually able to manage their symptoms with ... About Raynaud's phenomenon. Raynaud's phenomenon is a condition in which there is an exaggerated blood vessel tightening in ... Some people with Raynaud's phenomenon even find it helpful to wear cotton gloves or oven mitts reach into freezers, to protect ...
  http://arthritisbroadcastnetwork.org/2017/03/raynauds-may-common-women-childbearing-age/
*  Primary Raynaud's phenomenon in monozygotic twins | Annals of the Rheumatic Diseases
Familial aggregation of primary Raynaud's disease. Arthritis Rheum1996;39:1189-91. ... mixed connective tissue disease, systemic lupus erythematosus, occlusive vascular disease, drug effects, haematological ... The genetic contribution to Raynaud's phenomenon: a population-based twin study [abstract]. Arthritis Rheum1999;42(suppl):S233. ... Raynaud's phenomenon: a proposal for classification. Clin Exp Rheumatol1992;10:485-8. ...
  http://ard.bmj.com/content/63/2/219
*  Raynaud's disease testing Buffalo Niagaraa Raynaud's phenomenon testing Buffalo Niagara
Testing fo Raynaud's disease and Raynaud's phenomenon at an ACR Accredited Vascular Lab in Buffalo Niagara at the Vein ... To schedule a test to diagnose Raynaud's disease or Raynaud's phenomenon, call to schedule an appointment at 716-839-3638. ... Karamanoukian has written a book about Raynaud's disease which is available for free to read on an ebook reader. ... Vascular Lab and performs the entire gamet of vascular diagnostic testing including Doppler for Raynaud's disease and Raynaud's ...
  http://peacebridgehealthcare.com/blog/44/accredited-vascular-lab-for-raynauds-testing-in-williamsville-ny-and-clarence-ny.aspx
*  Dose Response Study of a Topical Formulation of Nitroglycerin for the Treatment of Raynaud's Phenomenon - Full Text View -...
Raynaud's Disease. Raynaud's disease secondary to scleroderma. Raynaud's phenomenon secondary to autoimmune disease. ... Raynaud Disease. Peripheral Vascular Diseases. Vascular Diseases. Cardiovascular Diseases. Nitroglycerin. Vasodilator Agents. ... Patients may have moderate to severe primary Raynaud's phenomenon or Raynaud's phenomenon secondary to autoimmune diseases such ... Dose Response Study of a Topical Formulation of Nitroglycerin for the Treatment of Raynaud's Phenomenon. This study has been ...
  https://clinicaltrials.gov/ct2/show/NCT00480753?term=Raynaud
*  HealthDay - Raynaud's Disease News
People who have Raynaud's may have normal blood flow some of the time, but occasional episodes where the blood vessels narrow ... Raynaud's is a rare disorder that affects blood flow in the arteries. ... When the cause of Raynaud's isn't known, it is often referred to as primary Raynaud's or Raynaud's disease. Raynaud's can also ... Raynaud's Disease News. Raynaud's is a rare disorder that affects blood flow in the arteries. People who have Raynaud's may ...
  https://consumer.healthday.com/cardiovascular-and-health-information-20/raynaud-s-disease-news-573/
*  Pins and Needles and Raynaud's Disease
Raynaud's phenomenon is a relatively rare medical condition which causes a reduction of blood circulation to the fingers or ... Primary Raynaud's phenomenon is also called Raynaud's disease. It may be very mild, never requiring a medical consultation. It ... Types of Raynaud's phenomenon. Raynaud's phenomenon may be primary, which means it sets in without any other medical condition ... Raynaud's phenomenon is a relatively rare medical condition which causes a reduction of blood circulation to the fingers or ...
  https://www.news-medical.net/health/Pins-and-Needles-and-Raynaude28099s-Disease.aspx
*  Raynaud's disease - Harvard Health
Raynaud's disease is a condition in which fingers, toes, or other body parts turn blue or white in response to cold. For some ... Raynaud's disease. Published: December, 2014. Raynaud's disease is a condition in which fingers, toes, or other body parts turn ... Treating Raynaud's disease. Prevention is the best medicine for Raynaud's: stay out of the cold if possible, bundle up when it ... Diagnosing Raynaud's disease. Raynaud's is usually diagnosed by the description you give your doctor. Tests usually aren't ...
  https://www.health.harvard.edu/pain/raynauds-disease-overview
*  Can you tell me about Raynaud's disease?
... These fluctuations in blood flow are most noticeable in the skin. We flush pink when ... Raynaud's disease is a condition in which the blood flow to the fingers is restricted by excessive, inappropriate ... They are usually diseases in which the immune system is faulty and prone to attack its own tissues (autoimmune disease), such ... What is graft versus host disease?. Graft versus host disease is a very rare complication of giving blood transfusions to ...
  http://www.netdoctor.co.uk/ask-the-expert/heart-and-blood/a1050/can-you-tell-me-about-raynauds-disease/
*  Niacin and Raynaud's Disease | LIVESTRONG.COM
A close-up of the hands of a man with Raynaud's disease on a cold day outside. Photo Credit: Jaim924/iStock/Getty Images ... If you have Raynaud's disease, this natural response might be exaggerated. A brief exposure to cold, contact with a freezer or ... Raynaud's disease might be an early sign of a more serious underlying circulatory condition. Consult your health care provider ... Niacin and Raynaud's Disease by ANNE TOURNEY Last Updated: Oct 03, 2017. ...
  https://www.livestrong.com/article/355669-niacin-and-raynauds-disease/
*  Raynaud's disease - Southern Cross NZ
Raynaud's disease affects the blood circulation in fingers and toes when exposed to cold, temperature change or stress. ... Secondary Raynaud's disease can develop at any age.. Signs and symptoms. Raynaud's disease occurs in "episodes", where symptoms ... Raynaud's disease (also referred to as Raynaud's syndrome or Raynaud's phenomenon) is estimated to affect up to 10% of New ... Secondary Raynaud's disease is so called because it occurs secondary to another condition or factor, such as: *Diseases that ...
  https://www.southerncross.co.nz/group/medical-library/raynauds-disease
*  Raynaud Disease (Aftercare Instructions) - What You Need to Know
Care guide for Raynaud Disease (Aftercare Instructions). Includes: possible causes, signs and symptoms, standard treatment ... Learn more about Raynaud Disease (Aftercare Instructions). Associated drugs. *Peripheral Arterial Disease ... Prevent a Raynaud disease attack:. *Avoid cold temperatures when possible: Wear gloves, scarves, or other winter garments ... Raynaud disease can be primary or secondary. Primary means it has no clear cause. Secondary means it has a cause and may be ...
  https://www.drugs.com/cg/raynaud-disease-aftercare-instructions.html
*  Nutrition's Effect on Raynaud's Disease
Nutrtional Tips for Raynaud's, Raynaud's Disease, Raynaud's Phenomenon, Raynaud's Sufferers, Raynaud's Syndrome, Raynuad's and ... Nutrition's Effect on Raynaud's Disease. October 3, 2010. by Frostie Leave a Comment ... The occurrence and severity of symptoms for those who battle Raynaud's disease is something that can be approached and, ... Filed Under: In The News Tagged With: Nutrition and Raynaud's, Nutritional Advice for Raynaud's Sufferers, ...
  http://www.raynauds.org/2010/10/03/nutitions-effect-on-raynauds-disease/
*  Raynaud's disease legal definition of Raynaud's disease
What is Raynaud's disease? Meaning of Raynaud's disease as a legal term. What does Raynaud's disease mean in law? ... Definition of Raynaud's disease in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Raynaud's disease legal definition of Raynaud's disease https://legal-dictionary.thefreedictionary.com/Raynaud%27s+disease ... disease. (redirected from Raynaud's disease). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia. disease. ...
  https://legal-dictionary.thefreedictionary.com/Raynaud
*  RAYNAUD'S DISEASE AND FILING FOR DISABILITY
4. Working with tools that vibrate can lead to developing Raynaud's disease. 5. Raynaud's disease symptoms occur in attacks ... Facts about Raynaud's Disease and Filing for Disability. These selected pages answer some of the most basic, but also some of ... 8. Raynaud's disease is typically mild and more of an annoyance to the affected individual than a health concern. 9. In the ... 1. Raynaud's disease restricts blood flow to the skin, causing the fingers, toes, nose and ears to become cold, numb and change ...
  http://www.ssdrc.com/ssd-raynauds.html
*  What is the link between Raynaud's disease and aspartame? | Reference.com
... none of them prove that aspartame causes any disease or negative health repercussions, as of 2015, according to Healthline. The ... Risk factors for Raynaud's disease include sex, age and family history. Although severe Raynaud's disease is very rare, it can ... There are two types of Raynaud's disease: primary and secondary. Some causes of secondary Raynaud's disease are connective ... In a person suffering from Raynaud's disease, narrowing arteries cause a decrease in blood flow. Symptoms of this disease are ...
  https://www.reference.com/health/between-raynaud-s-disease-aspartame-5a4dcc8102d5545e
*  DermIS - Raynaud's Disease (information on the diagnosis)
Disease, Raynaud, Disease, Raynaud's, Raynaud Disease, RAYNAUDS DISEASE, Raynaud's Disease, Raynaud's disease /phenomenon, ... Raynaud's disease is a term used to describe those cases where no other disease is found. It is much more common in women. ... Raynaud's Disease. definition. Paroxysmal pallor and coldness of the extremities, usually precipitated by cold, and followed by ... Cryoglobulinaemia (0)Raynaud's Syndrome (0)Acrocyanosis (0)Panarteritis Nodosa Kussmaul-Maier (0)Progressive Systemic ...
  http://www.dermis.net/dermisroot/en/25151/diagnosep.htm
*  Core77.com • View topic - Raynaud's Disease - hand & foot-warmers
I am starting a project that aims to help those with Raynaud's Disease and am having trouble deciding on a target market. I ... 15% of women between 15 and 40 in colder climates are the most common to have Raynaud's Disease, while about 3-5% of the world ... 15% of women between 15 and 40 in colder climates are the most common to have Raynaud's Disease, while about 3-5% of the world ... Re: Raynaud's Disease - hand & foot-warmers. by Robbie_roy » October 26th, 2012, 8:46 pm ...
  http://boards.core77.com/viewtopic.php?f=20&t=27717
*  Medical Marijuana and Raynaud's Disease - Marijuana Doctors
In severe cases of Raynaud's disease, the loss of blood flow can cause sores or death of tissues. ... Raynaud's disease is a rare disorder of the blood vessels, which usually develops in the fingers and toes. This condition ... Medical Marijuana and Raynaud's Disease. A primary case of Raynaud's disease occurs on its own. The cause of this specific ... Those who are located in colder climates are more likely to develop Raynaud's disease. This condition is also more common in ...
  https://www.marijuanadoctors.com/conditions/raynauds-disease/
*  Raynaud's disease/phenomenon | definition of Raynaud's disease/phenomenon by Medical dictionary
What is Raynaud's disease/phenomenon? Meaning of Raynaud's disease/phenomenon medical term. What does Raynaud's disease/ ... Looking for online definition of Raynaud's disease/phenomenon in the Medical Dictionary? Raynaud's disease/phenomenon ... Raynaud's disease. (redirected from Raynaud's disease/phenomenon). Also found in: Dictionary, Encyclopedia. Raynaud's Disease. ... A.G. Maurice Raynaud, 1834-81, French physician).. Raynaud's disease severe Raynaud's phenomenon; Raynaud's phenomenon of ,2 ...
  https://medical-dictionary.thefreedictionary.com/Raynaud
*  Raynaud's Disease Stock Image Search Results
Raynaud's Disease,Medical Illustration database of the best portfolios and stock images now features General and Commercial ... Addiction can be a disease of many forms; shown are: Alcohol abuse, addiction to pain medications, illicit drug abuse (cannab ... Editorial representation of the heart and panacreas and the effects of diabetes on coronary artery disease. The inset shows p ... Normal active kids in bubbles immunized against a background of bacteria and virus or various diseases.. ...
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*  Raynaud'S Disease: Symptoms, Causes, Treatment, and Diagnosis | FindATopDoc
Learn more about Raynaud'S Disease causes, sign and symptoms, treatment and diagnosis at FindaTopdoc. Read more information on ... The two main types of Raynaud's disease are:. Primary Raynaud's. Also known as Raynaud's disease is the result of an underlying ... 1 What is Raynaud's Disease?. Raynaud's disease causes some areas of your body especially your toes and fingers will feel cold ... There is no single test for Raynaud's disease diagnosis.. Consult your doctor if you have the symptoms of Raynaud's disease. He ...
  https://www.findatopdoc.com/Medical-Library/Diseases-and-Conditions/Raynaud-S-Disease
*  About Raynaud's - Heart Disease - MedHelp
I have some questions about Raynaud's. I'm not sure if this is the right forum to ask about it but if not, please refer me to ... About Raynaud's character28 Hi, I have some questions about Raynaud's. I'm not sure if this is the right forum to ask about it ... About Raynaud's. Hi, I have some questions about Raynaud's. I'm not sure if this is the right forum to ask about it but if not ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ...
  https://www.medhelp.org/posts/Heart-Disease/About-Raynauds/show/1796047
*  Frontiers | Role of sympathetic nerve activity in the process of fainting | Physiology
... and postoperative symptoms of lumbar sympathectomy for the treatment of Buerger's disease or Raynaud's syndrome all have an ... Structural brain abnormalities are associated with depression in the elderly, suggesting a link between vascular diseases to ... Addison's disease, and administration of diuretics. Hypovolemia results in a fluid shift to the lower body, causing ... Parkinson's disease with autonomic failure, and acute pandysautonomia. In addition to the primary autonomic failures, secondary ...
  https://www.frontiersin.org/articles/10.3389/fphys.2014.00343/full


(1/492) Traumatic vasospastic disease in chain-saw operators.

Raynaud's phenomenon is commonly induced in chain-saw operators by vibration; the hand guiding the tool is the more severely affected. The condition tends to persist after use of the chain-saw is stopped but compensation is rarely sought. Among 17 cases of Raynaud's phenomenon in lumberjacks the condition was found to be related to use of the chain-saw in 14, 10 of whom had to give up their work in colder weather because the disease was so disabling. Two criteria essential to establish the condition as vibration-induced Raynaud's phenomenon are the presence of symptoms for at least 2 years and a history of at least 1 year's constant use of the chain-saw. Careful physical examination and simple tests of vascular function will provide objective evidence of permanent damage by which the patients may be classified and compensated.  (+info)

(2/492) Different factors influencing the expression of Raynaud's phenomenon in men and women.

OBJECTIVE: To determine whether the risk profile for Raynaud's phenomenon (RP) is different between men and women. METHODS: In this cross-sectional study of 800 women and 725 men participating in the Framingham Offspring Study, the association of age, marital status, smoking, alcohol use, diabetes, hypertension, and hypercholesterolemia with prevalent RP was examined in men and women separately, after adjusting for relevant confounders. RESULTS: The prevalence of RP was 9.6% (n = 77) in women and 5.8% (n = 42) in men. In women, marital status and alcohol use were each associated with prevalent RP (for marital status adjusted odds ratio [OR] 2.3, 95% confidence interval [95% CI] 1.4-3.9; for alcohol use OR 2.2, 95% CI 1.0-5.2), whereas these factors were not associated with RP in men (marital status OR 1.4, 95% CI 0.6-3.5; alcohol use OR 1.0, 95% CI 0.2-4.4). In men, older age (OR 2.3, 95% CI 1.0-5.2) and smoking (OR 2.6, 95% CI 1.1-6.3) were associated with prevalent RP; these factors were not associated with RP in women (older age OR 0.8, 95% CI 0.4-1.6; smoking OR 0.7, 95% CI 0.4-1.1). Diabetes, hypertension, and hypercholesterolemia were not associated with RP in either sex. CONCLUSION: The results indicate that risk factors for RP differ between men and women. Age and smoking were associated with RP in men only, while the associations of marital status and alcohol use with RP were observed in women only. These findings suggest that different mechanisms influence the expression of RP in men and women.  (+info)

(3/492) Increased interferon-gamma (IFN-gamma) levels produced in vitro by alloactivated T lymphocytes in systemic sclerosis and Raynaud's phenomenon.

The aim of the present study was to analyse the in vitro proliferation and cytokine production by alloantigen-stimulated peripheral blood mononuclear cells (PBMC) obtained from patients affected by systemic sclerosis (SSc) and patients with Raynaud's phenomenon (RP). In SSc patients the proliferation of PBMC stimulated in vitro with alloantigens was significantly increased compared with healthy subjects, while no differences were observed for RP patients. Lymphocytes from SSc patients also produced larger amounts of IFN-gamma compared with healthy controls. However, patients with clinically active disease had lower IFN-gamma levels than those found in clinically stable patients. Patients affected by RP showed significantly higher levels of IFN-gamma than healthy subjects. Analysis at the clonal level of the lymphocyte subsets involved in alloantigen stimulation in one patient affected by active SSc, and one subject with RP confirmed the results obtained using PBMC. In particular, in the RP patient but not in the SSc patient, we observed a population of CD4+ T cells which proliferated to alloantigens in vitro and produced high levels of IFN-gamma. We suggest that T lymphocytes producing high levels of IFN-gamma might play a protective role in RP patients and in established scleroderma.  (+info)

(4/492) Activation of microvascular pericytes in autoimmune Raynaud's phenomenon and systemic sclerosis.

OBJECTIVE: To determine the temporal and spatial relationship between platelet-derived growth factor beta (PDGFbeta) receptors, PDGF-AB/BB, and activated pericytes across the Raynaud's phenomenon (RP) and systemic sclerosis (SSc; scleroderma) disease spectrum. METHODS: Monoclonal antibodies against PDGFbeta receptors, PDGF-AB/BB, and high molecular weight-melanoma-associated antigen (HMW-MAA), a marker for activated pericytes, were used to immunohistochemically analyze serial sections of skin biopsy tissue from patients with RP and from scleroderma patients. To delineate cell-specific PDGFbeta receptor expression, double immunofluorescence-stained sections were analyzed using computer-aided image analysis and confocal microscopy. RESULTS: PDGFbeta receptor-expressing cells and HMW-MAA-expressing pericytes were found in biopsy samples from autoimmune RP patients and in both early fibrotic and early nonfibrotic scleroderma skin, but not in normal or primary RP or late-stage scleroderma skin. PDGF-AB/BB was expressed within the epidermis, at the epidermal/dermal junction, and by dermal macrophages. Analysis of juxtaposed serial sections revealed an increased frequency of receptor expression in microvessels from autoimmune RP and early scleroderma skin (P < 0.01). Double-labeling studies using confocal microscopy showed that, in vivo, PDGFbeta receptors were predominantly expressed by microvascular pericytes from both autoimmune RP and early scleroderma skin. CONCLUSION: PDGFbeta receptors are expressed by activated microvascular pericytes in patients with autoimmune RP and in early SSc patients, but not in those with primary RP or late-stage scleroderma. These findings suggest that features of autoimmune RP are distinct from those of primary RP, and that microvascular pericytes may be an important link between chronic microvascular damage and fibrosis.  (+info)

(5/492) Cardiovascular responses evoked by mild cool stimuli in primary Raynaud's disease: the role of endothelin.

In control subjects and in subjects with primary Raynaud's disease, sudden sound evokes the pattern of the alerting response, which includes cutaneous vasoconstriction and vasodilatation in forearm muscle. However, whereas this pattern of response habituates on repetition of the sound stimulus in control subjects, both cutaneous vasoconstriction and muscle dilatation persist in subjects with primary Raynaud's disease. The aim of the present study was to test whether a similar disparity exists between control subjects and those with primary Raynaud's disease for the response to mild cool stimuli, and whether the cutaneous response is accompanied by the release of endothelin-1 (ET-1). In nine subjects with primary Raynaud's disease and in nine matched controls, the left hand was placed in cool water at 16 degrees C for 2 min five times on each of three experimental sessions on days 1, 3 and 5, with blood being taken from the venous drainage of the cooled hand before and at the end of the second session. In response to the first cool stimulus in Session 1, the subjects with primary Raynaud's disease showed a decrease in digital cutaneous vascular conductance (DCVC) in both the right and left hands, as indicated by a laser Doppler recording of erythrocyte (red cell) flux divided by arterial pressure, and six of the nine subjects showed an increase in forearm vascular conductance (FVC), as indicated by forearm blood flow measured by plethysmography divided by arterial pressure. On repetition of the stimulus in Session 1, there was no change in the magnitude of the increase in FVC, but the evoked decreases in DCVC became more prolonged in both the right and the left hand. Similar responses occurred in Sessions 2 and 3; in Session 2, the ET-1 concentration increased from a baseline value of 2.15+/-0.26 fM to 2.72+/-0.37 fM after five stimuli. There was no habituation of the increase in FVC over Sessions 1, 2 and 3, judging from the mean changes in each session. Control subjects also showed a decrease in DCVC in both hands, and in eight out of nine subjects there was an increase in FVC in response to the first cool stimulus in Session 1. However, on repetition of the stimulus in Session 1, the increase in FVC habituated, while there was no prolongation of the decrease in DCVC; in addition, the ET-1 concentration did not change in Session 2 in response to the stimulus (2.07+/-0.28 compared with 2.29+/-0.30 fM). Further, the increase in FVC habituated over the three sessions, such that there was a mean decrease in FVC in Session 3. These results indicate that, in subjects with primary Raynaud's disease, there is impairment of the ability of the central nervous system to allow habituation of the cardiovascular components of the alerting response evoked by mild cooling, as with the response to sound. We propose that persistence of the cutaneous vasoconstriction of the alerting response, coupled with increased release of ET-1 secondary to vasoconstriction, prolongs such vasoconstriction and eventually leads to vasospasm.  (+info)

(6/492) Impaired cholinergic dilator response of resistance arteries isolated from patients with Raynaud's disease.

AIMS: We examined the effect of cooling on the response to the endothelium-dependent and -independent dilators, acetylcholine (ACh) and sodium nitroprusside (SNP), respectively, in human microvessels in vitro, and compared the responses between Raynaud's disease (RD) patients and controls, in order to assess the pathogenic role of the endothelium in RD. METHODS: Subcutaneous resistance arteries were dissected from gluteal fat biopsies taken from patients with RD (n=18) and from age-and sex-matched control subjects (n=17). Vessels were cannulated in a small vessel arteriograph, in which a pressure of 50 mmHg was maintained across the vessel wall. Cumulative concentration-response curves for ACh (10-10-10-4 m ) and SNP (10-10-10-3 m ) were generated in vessels at either 37 degrees C or 24 degrees C, with endothelium intact for ACh and removed for SNP (n=6 per group). RESULTS: Neither dilator showed significant differences in sensitivity when comparing responses between vessels from RD patients and controls, at either temperature, but the maximal relaxation to ACh was depressed in vessels from RD patients compared with controls at 37 degrees C (Emax=45+/-13 in RD vs 89+/-4 in controls; P=0.004). CONCLUSIONS: These results support the hypothesis that impaired endothelium-dependent vasodilatation is involved in the pathophysiology of RD.  (+info)

(7/492) Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon.

OBJECTIVE: Reactive oxygen species have been implicated in the pathogenesis of inflammatory and vascular disease. We have undertaken a controlled trial to evaluate probucol, a synthetic antioxidant, as a potential therapy for Raynaud's phenomenon. METHODS: The study cohort included patients with systemic sclerosis (SSc; n = 20), primary Raynaud's phenomenon (n = 15) or 'autoimmune Raynaud's' (n = 5). Patients were allocated to receive either probucol (500 mg daily) or nifedipine (20 mg daily) for 12 weeks. Clinical and biochemical variables at baseline were compared with those at completion of treatment. Evaluation included assessment of Raynaud's attack frequency and severity by visual analogue scale, measurement of low-density lipoprotein (LDL) oxidation lag time, and plasma concentrations of cholesterol, triglyceride, vitamin E and vitamin C. RESULTS: There was a significant reduction of both the frequency and severity of Raynaud's attacks in the patients who received probucol, but not in the control group. LDL oxidation lag time, reflecting in vitro susceptibility to oxidation, was also increased by probucol therapy and serum cholesterol levels were significantly reduced. Similar changes were observed in both SSc- and non-SSc-associated Raynaud's cases. CONCLUSION: These data suggest that probucol may be useful for the symptomatic treatment of Raynaud's phenomenon and also reduces LDL oxidation susceptibility. Since oxidized lipoproteins may mediate vascular damage in SSc, the use of probucol could have additional disease-modifying benefits. Based upon the results of this pilot study, further evaluation of this novel form of therapy is warranted.  (+info)

(8/492) Raynaud's syndrome in workers who use vibrating pneumatic air knives.

PURPOSE: The use of vibrating tools has been shown to cause Raynaud's syndrome (RS) in a variety of workers, including those who use chain saws, chippers, and grinders. The diagnosis of RS in workers who use vibrating tools is difficult to document objectively. We studied a patient cohort with RS caused by the use of a vibrating pneumatic air knife (PAK) for removal of automobile windshields and determined our ability to document RS in these workers by means of digital hypothermic challenge testing (DHCT), a vascular laboratory study that evaluates digital blood pressure response to cooling. METHODS: Sixteen male autoglass workers (mean age, 36 years) with RS were examined by means of history, physical examination, arm blood pressures, digital photoplethysmography, screening serologic studies for underlying connective tissue disorder, and DHCT. RESULTS: No patient had RS before they used a PAK. The mean onset of RS (color changes, 100%; pain, 93%; parathesias, 75%) with cold exposure was 3 years (range, 1.5 to 5 years) after initial PAK use (mean estimated PAK use, 2450 hours). Fifty-six percent of workers smoked cigarettes. The findings of the physical examination, arm blood pressures, digital photoplethysmography, and serologic testing were normal in all patients. At 10 degrees C cooling with digital cuff and patient cooling blanket, a significant decrease in digital blood pressure was shown by means of DHCT in 100% of test fingers versus normothermic control fingers (mean decrease, 75%; range, 25% to 100%; normal response, less than 17%; P <.001). The mean follow-up period was 18 months (range, 1 to 47 months). No patient continued to use the PAK, but symptoms of RS were unchanged in 69% and worse in 31%. CONCLUSION: PAK use is a possible cause of vibration-induced RS. The presence of RS in workers who use the PAK was objectively confirmed by means of DHCT. Cessation of PAK use in the short term did not result in symptomatic improvement.  (+info)



  • congestive heart f
  • Clinical investigation topics include congestive heart failure, Raynaud's disease and mitral valve disease. (wikipedia.org)
  • Although alpha blockers can only treat a small range of diseases, some of them have clinical uses, such as having the ability to treat hypertension, Raynaud's disease, Congestive Heart Failure, erectile dysfunction, etc. (wikipedia.org)
  • While there are limited clinical α-blocker uses, in which most α-blockers are used for hypertension or benign prostatic hyperplasia , α-blockers can be used to treat a few other diseases, such as Raynaud's Disease, Congestive Heart Failure, Pheochromocytoma, and Erectile Dysfunction. (wikipedia.org)
  • arteries
  • This disease will limit your blood circulation to affected areas (vasospasm) because of the smaller arteries that supply blood to your skin narrow. (findatopdoc.com)
  • Vascular disease is a class of diseases of the blood vessels - the arteries and veins of the circulatory system of the body. (wikipedia.org)
  • citation needed] Peripheral artery disease - happens when atheromatous plaques build up in the arteries that supply blood to the arms and legs, plaque causes the arteries to narrow or become blocked. (wikipedia.org)
  • citation needed] Vascular disease is a pathological state of large and medium muscular arteries and is triggered by endothelial cell dysfunction. (wikipedia.org)
  • Raynaud syndrome, also known as Raynaud's phenomenon, is a medical condition in which spasm of arteries cause episodes of reduced blood flow. (wikipedia.org)
  • Syndrome
  • Raynaud's disease (also referred to as Raynaud's syndrome or Raynaud's phenomenon) is estimated to affect up to 10% of New Zealanders. (southerncross.co.nz)
  • Familial cold urticaria (also properly known as familial cold autoinflammatory syndrome, FCAS) is an autosomal dominant condition characterized by rash, conjunctivitis, fever/chills and arthralgias elicited by exposure to cold - sometimes temperatures below 22 °C (72 °F). It has been mapped to CIAS1 and is a slightly milder member of the disease family including Muckle-Wells syndrome and NOMID. (wikipedia.org)
  • There are reports of ETS being used to achieve cerebral revascularization for people with moyamoya disease, and to treat headaches, hyperactive bronchial tubes, long QT syndrome, social phobia, anxiety, and other conditions. (wikipedia.org)
  • peripheral
  • In the case of a peripheral vascular disease the physical exam consists in checking the blood flow in the legs. (wikipedia.org)
  • How Is Peripheral Arterial Disease Treated? (wikipedia.org)
  • From 1968, at Bellevue Hospital Center Bartenieff's work involved cases of the control/restoration of movement patterns governed by the central nervous system rather than the treatment of peripheral problems in the affected muscles of polio patients (polio is a peripheral motor neuron disease). (wikipedia.org)
  • He was a clinical and research fellow in peripheral vascular disease at the Evans Memorial Foundation for Clinical Research in Boston (1977-1978) and a fellow in cardiology at Boston City Hospital (1978-1980). (wikipedia.org)
  • Acute and chronic peripheral metabolic-vascular disorders (organic and functional arteriopathies of the limbs), Raynaud's disease and other syndromes caused by altered peripheral irrigation. (wikipedia.org)
  • Avoid
  • A survey of patients in the United States in 2008 found, "To cope with their underlying disease and to try to avoid symptomatic, painful, flares patients reported limiting their work, school, family, and social activities. (wikipedia.org)
  • person's
  • Medical experts observe a link between creases in a person's earlobe and the risk of heart disease, explains Healthline. (reference.com)
  • tissues
  • It is also possible to cure diseases of the extraarticular tissues of the musculoskeletal system, nonspecific arthritis of infectious genesis and post-traumatic osteoporosis. (wikipedia.org)
  • causes
  • Although there have been many studies on aspartame, none of them prove that aspartame causes any disease or negative health repercussions, as of 2015, according to Healthline. (reference.com)
  • Treatment
  • Men are prescribed naftalan for the fight against prostatitis, and children from 5 years old - for the treatment of diathesis and other allergies, as well as inflammatory skin diseases with pustular formations. (wikipedia.org)
  • Cyclandelate is a vasodilator used in the treatment of claudication, arteriosclerosis and Raynaud's disease. (wikipedia.org)
  • Surgical elimination of the stellate ganglion (sympathectomy) is a treatment of last resort for Raynaud's disease. (wikipedia.org)
  • Adson undertook innovative neurosurgery for the treatment of glossopharyngeal neuralgia, Raynaud's Disease, Hirschsprung's disease and for essential hypertension. (wikipedia.org)
  • condition
  • Pilonidal sinus disease is a condition where small abscesses or cysts containing debris, dirt and hair form at the top of the buttocks in the cleft, as sta. (reference.com)
  • It is named after the French physician Maurice Raynaud, who described the condition in 1862. (wikipedia.org)