Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Eclampsia: Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).Hypertension, Pregnancy-Induced: A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.HELLP Syndrome: A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.Uterine Artery: A branch arising from the internal iliac artery in females, that supplies blood to the uterus.Pregnancy Trimester, Second: The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.Placental Circulation: The circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA.Fetal Growth Retardation: The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.Pregnancy Complications, Cardiovascular: The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Pregnancy Trimester, First: The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.Abruptio Placentae: Premature separation of the normally implanted PLACENTA from the UTERUS. Signs of varying degree of severity include UTERINE BLEEDING, uterine MUSCLE HYPERTONIA, and FETAL DISTRESS or FETAL DEATH.Uterus: The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus (the body) which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES.Ultrasonography, Doppler, Pulsed: Ultrasonography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return.Pulsatile Flow: Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Ultrasonography, Prenatal: The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.Pregnancy Trimester, Third: The last third of a human PREGNANCY, from the beginning of the 29th through the 42nd completed week (197 to 294 days) of gestation.Magnesium Sulfate: A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)Pregnancy Complications: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.Pregnancy Proteins: Proteins produced by organs of the mother or the PLACENTA during PREGNANCY. These proteins may be pregnancy-specific (present only during pregnancy) or pregnancy-associated (present during pregnancy or under other conditions such as hormone therapy or certain malignancies.)Placentation: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Arteries: The vessels carrying blood away from the heart.Pregnancy-Associated Plasma Protein-A: A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.Ultrasonography, Doppler, Color: Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.Infant, Small for Gestational Age: An infant having a birth weight lower than expected for its gestational age.Paternity: Establishing the father relationship of a man and a child.Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Ultrasonography, Doppler: Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)Galectins: A class of animal lectins that bind specifically to beta-galactoside in a calcium-independent manner. Members of this class are distiguished from other lectins by the presence of a conserved carbohydrate recognition domain. The majority of proteins in this class bind to sugar molecules in a sulfhydryl-dependent manner and are often referred to as S-type lectins, however this property is not required for membership in this class.Gravidity: The number of pregnancies, complete or incomplete, experienced by a female. It is different from PARITY, which is the number of offspring borne. (From Stedman, 26th ed)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Infant, Newborn: An infant during the first month after birth.Parity: The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.Neuroprostanes: Prostaglandin-like compounds produced by free radical-induced peroxidation of DOCOSAHEXAENOIC ACIDS, which are highly enriched in the brain. Formation is analogous to ISOPROSTANES formation from ARACHIDONIC ACID.Maternal Age: The age of the mother in PREGNANCY.Cesarean Section: Extraction of the FETUS by means of abdominal HYSTEROTOMY.Placental Function Tests: Methods used for the assessment of placental function.Obstetric Labor, Premature: Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE).Pregnancy, High-Risk: Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.Maternal Mortality: Maternal deaths resulting from complications of pregnancy and childbirth in a given population.Stillbirth: The event that a FETUS is born dead or stillborn.Puerperal Disorders: Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.Inhibin-beta Subunits: They are glycopeptides and subunits in INHIBINS and ACTIVINS. Inhibins and activins belong to the transforming growth factor beta superfamily.Umbilical Arteries: Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.Crown-Rump Length: In utero measurement corresponding to the sitting height (crown to rump) of the fetus. Length is considered a more accurate criterion of the age of the fetus than is the weight. The average crown-rump length of the fetus at term is 36 cm. (From Williams Obstetrics, 18th ed, p91)Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Fathers: Male parents, human or animal.HLA-G Antigens: Class I human histocompatibility (HLA) surface antigens encoded by alleles on locus B of the HLA complex. The HLA-G antigens are considered non-classical class I antigens due to their distinct tissue distribution which differs from HLA-A; HLA-B; and HLA-C antigens. Note that several isoforms of HLA-G antigens result from alternative splicing of messenger RNAs produced from the HLA-G*01 allele.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Cardiotocography: Monitoring of FETAL HEART frequency before birth in order to assess impending prematurity in relation to the pattern or intensity of antepartum UTERINE CONTRACTION.Maternal-Fetal Exchange: Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.NorwayInhibins: Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectivelyDelivery, Obstetric: Delivery of the FETUS and PLACENTA under the care of an obstetrician or a health worker. Obstetric deliveries may involve physical, psychological, medical, or surgical interventions.Pregnancy, Multiple: The condition of carrying two or more FETUSES simultaneously.Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Pregnancy Trimesters: The three approximately equal periods of a normal human PREGNANCY. Each trimester is about three months or 13 to 14 weeks in duration depending on the designation of the first day of gestation.Vascular Endothelial Growth Factor Receptor-1: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.Placental Insufficiency: Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.Birth Order: The sequence in which children are born into the family.Perinatal Mortality: Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.Placenta Diseases: Pathological processes or abnormal functions of the PLACENTA.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Prenatal Care: Care provided the pregnant woman in order to prevent complications, and decrease the incidence of maternal and prenatal mortality.Birth Intervals: The lengths of intervals between births to women in the population.Apgar Score: A method, developed by Dr. Virginia Apgar, to evaluate a newborn's adjustment to extrauterine life. Five items - heart rate, respiratory effort, muscle tone, reflex irritability, and color - are evaluated 60 seconds after birth and again five minutes later on a scale from 0-2, 0 being the lowest, 2 being normal. The five numbers are added for the Apgar score. A score of 0-3 represents severe distress, 4-7 indicates moderate distress, and a score of 7-10 predicts an absence of difficulty in adjusting to extrauterine life.Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Decidua: The hormone-responsive glandular layer of ENDOMETRIUM that sloughs off at each menstrual flow (decidua menstrualis) or at the termination of pregnancy. During pregnancy, the thickest part of the decidua forms the maternal portion of the PLACENTA, thus named decidua placentalis. The thin portion of the decidua covering the rest of the embryo is the decidua capsularis.Birth Weight: The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.

*  ACOG's Continuing Commitment to Preeclampsia Progress - ACOG

Committee Opinion #514: "Emergent Therapy for Acute-Onset, Severe Hypertension With Preeclampsia or Eclampsia" (December 2011) ... Severe Hypertension With Preeclampsia or Eclampsia"), which focuses on the management of sudden severe hypertension due to ... The Task Force made headway in this quest by providing physicians and patients with a better understanding of preeclampsia and ... An ultimate goal is to eliminate fetal, perinatal, and maternal morbidity and mortality caused by preeclampsia and the other ...

*  Preeclampsia & Eclampsia: The Warning Signs You Need to Know | CafeMom

This is by no means complete information on preeclampsia and eclampsia. To learn more, check out the Preeclampsia Foundation's ... And then pretty much five seconds after my son was born, I forgot all about what preeclampsia and eclampsia are. So just to ... Here's what I learned about preeclampsia and eclampsia from WebMD and the U.S. National Library of Medicine. ... Eclampsia is one of the reasons your doctor or midwife wants to see you and take your blood pressure all the time. Because THIS ...

*  Vancouver walkathon - Welcome to the Preeclampsia Foundation

My wife, Laura Magee (obstetric internist), and I share the leadership of the local pre-eclampsia research group and are very ... As Fiona knows, I'm a pre-eclampsia researcher (obstetrician-scientist)based at BC Women's. ... I'm very glad to have discovered this website and forum, as I was recently diagnosed with eclampsia. I delivered twins on April ...

*  About this Forum - Welcome to the Preeclampsia Foundation

Is pre-eclampsia considered a pre-existing condition ?? Last post by yachna1425 « Mon Nov 06, 2017 12:50 am ... Announcements and Preeclampsia in the News The Preeclampsia Foundation does not necessarily endorse any research or news found ... Preeclampsia FAQ Pamphlets' Last post by yachna1425 « Mon Nov 06, 2017 12:42 am ... Would you like to share your appreciation for the Preeclampsia Foundation? Please post your comments here... Topics: 13 ...

*  Pregnant with Twins - Welcome to the Preeclampsia Foundation

I had HELLP with my 1st baby which ended in a loss at 21 weeks, I had mild pre-eclampsia with my 2nd pregnant but she is a ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Pregnant Again? ... Doc gave me a mild preeclampsia diagnosis anyway and said I'm likely to be a chronic hypertensive later in life. ... Are you pregnant again after having preeclampsia once already in a previous pregnancy? Post your thoughts/concerns here - there ...

*  Remembering our Angels... - Welcome to the Preeclampsia Foundation

Born at 28 weeks due to severe pre-eclampsia. Died at 28 days old of pneumonia. 610 grams at birth. 950 grams at death. My ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Grief and Loss ... Ainsley 11/26/02-36 Weeks Preeclampsia. http://www.babiesonline.com/babies/a/ainsleyk/. ...

*  Saving Grace 2011? - Welcome to the Preeclampsia Foundation

Tyler (3/9/1995 ~ 3/23/1995) 26 weeks 3 days, 15 ounces, Eclampsia, HELLP, IUGR ... Welcome to the Preeclampsia Foundation Board index About this Forum Announcements and Preeclampsia in the News ... Nicole.Purnell@preeclampsia.org. Promise Walk for Preeclampsia Regional Coach. DFW Promise Walk Chair. ^i^ Cooper - 12-28-05 ... The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times). Looking for recent ...

*  BioNews - High blood pressure and pre-eclampsia risk raised in egg-donation pregnancies

The risk of pre-eclampsia after IVF with donated eggs was 11 percent, increased from three percent in other patients. ... Women who have conceived through IVF may be more likely to develop pre-eclampsia during pregnancy than pregnant women who have ... High blood pressure and pre-eclampsia risk raised in egg-donation pregnancies. 07 July 2014 ... women who used donor eggs in their treatment were four times more likely than women using their own eggs to get pre-eclampsia, ...

*  Serum Markers for the Prediction of Preeclampsia | OMICS International

Preeclampsia is one of the major causes of perinatal morbidity and mortality. There is urgent need for a first trimester marker ... Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomized placebo- ... Wald NJ1, Morris JK, Ibison J, Wu T, George LM (2006) Screening in early pregnancy for pre-eclampsia using Down syndrome ... Onwudiwe N, Yu CK, Poon LC, Spiliopoulos I, Nicolaides KH (2008) Prediction of pre-eclampsia by a combination of maternal ...

*  UMMC clinicians, researchers tackle preeclampsia - University of Mississippi Medical Center

It usually starts after 20 weeks gestation, and in the worst cases, it can lead to eclampsia which is seizures.' Preeclampsia ... Nationwide about 15 percent of all premature births are due to preeclampsia. 'The only cure for preeclampsia is delivery, and ... If we can optimize a woman's health and prevent a few cases of preeclampsia or even delay the onset of preeclampsia a little ... It was her first pregnancy and the new mother-to-be had no idea she was at risk of preeclampsia.On the night she passed out at ...

*  Pathophysiology of Hypertension During Preeclampsia Linking Placental Ischemia With Endothelial Dysfunction | Hypertension

Conrad KP, Animal models of pre-eclampsia: do they exist? Fetal Med Rev. . 1990; 2: 67-88. ... Many markers of endothelial dysfunction have been reported in women who develop preeclampsia, suggesting that preeclampsia is ... Placental Ischemia Is an Important Initiating Event in Preeclampsia. Although the pathophysiology of preeclampsia remains ... and other features of preeclampsia is unknown. Consistent with a potential role of cytokine activation in preeclampsia is a ...

*  Another Baby lost to PE - Welcome to the Preeclampsia Foundation

Born at 28 weeks due to severe pre-eclampsia. Died at 28 days old of pneumonia. 610 grams at birth. 950 grams at death. My ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Grief and Loss ... Ds Nicky - 3/24/00 (28 wks - eclampsia). Ds Kalen - 7/10/03 (36 weeks - preeclampsia). ... Mom to Finn, Lucy (preeclampsia and HELLP) and Chloe.. Moderator HELLP Syndrome Survivors ...

*  Julie--How are you doing? - Welcome to the Preeclampsia Foundation

Ds Nicky - 3/24/00 (28 wks - eclampsia). Ds Kalen - 7/10/03 (36 weeks - preeclampsia). ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Grief and Loss ...

*  What to do about.......advice - Welcome to the Preeclampsia Foundation

I lost my baby girl at 24 weeks due to severe pre-eclampsia.. We had only bought a few items and these were second hand. A few ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Grief and Loss ... 2010- Lil' Bro, Pre-E at 29 weeks... Induced at 36w6d, Born 37w. 2012- Lil' Sis, Super-imposed pre-e at 25 weeks, PTL & GD at ... 2010- Lil' Bro, Pre-E at 29 weeks... Induced at 36w6d, Born 37w. 2012- Lil' Sis, Super-imposed pre-e at 25 weeks, PTL & GD at ...

*  What do you say about preeclampsia? - Welcome to the Preeclampsia Foundation

Ds Nicky - 3/24/00 (28 wks - eclampsia). Ds Kalen - 7/10/03 (36 weeks - preeclampsia) ... Welcome to the Preeclampsia Foundation Board index About this Forum News from PF Headquarters ... I know how hard it is to decide whether or not to bring up the Pre-e with other women....I always feel like that is the center ... I figure it's better to scare someone a little than to risk having another pre-e mom as uninformed as I was up until I had my ...

*  HELP! Labour stopped, 1cm dilated. Been 4 days. Poss pre-eclampsia. | Mumsnet Discussion

they checked me over and said showing signs of pre-eclampsia. bp is up and liver levels in blood up. baby put on monitor and ... ive got to go into hosp tomorrow for them to check me over again and i have to keep an eye on warning signs for preeclampsia. ... I had preeclampsia and they induced me at 38+4. It's possible they're hoping for it to happen naturally? NICE guidelines ... suggest getting baby out ASAP post 37 weeks if preeclampsia is suspected. ...

*  Recent survivor of HELLP in Mont Co. - Welcome to the Preeclampsia Foundation

I was induced at 38w3d with mild pre-eclampsia (protein in urine and swelling only). Within 24 hours of delivering my son ... Preeclampsia Foundation Volunteer. Lehigh Valley Promise Walk. [i]Postpartum HELLP Syndrome Survivor 2011. Son born healthy at ... for more information, please visit www.preeclampsia.org. La Directora de las Relaciones con la Comunidad. *no ofrece consejo ... Director of Community Relations for the Preeclampsia Foundation. *does not provide any medical advice*. ...

*  First time mom with baby in NICU - Welcome to the Preeclampsia Foundation

Tyler (3/9/1995 ~ 3/23/1995) 26 weeks 3 days, 15 ounces, Eclampsia, HELLP, IUGR ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Parents of Preemies ... My son was 27+5, and I had HELLP and pre-e as well. We got so used to the routine at the NICU for 92 days that we felt strange ... Daniel born Feb 09 at 27w5d, 1 lb 1 oz/12 inches (severe IUGR) due to Severe Pre-E & HELLP. Now tall for age and no ...

*  The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community | The BMJ

The pre-eclampsia.... *The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in ... Superimposed pre-eclampsia. Development of features of pre-eclampsia in context of pre-existing hypertension or pre-existing ... The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community BMJ 2005; ... The pre-eclampsia community guideline (PRECOG): how to screen for and detect onset of pre-eclampsia in the community. BMJ 2005 ...

*  Terrified of pre E in my next pregnancy!! - Welcome to the Preeclampsia Foundation

I consider myself fortunate as we have a healthy baby girl and I recovered without developing Eclampsia after her birth. My ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Trying Again after Preeclampsia ... Terrified of pre E in my next pregnancy!!. Are you considering having another child after preeclampsia? Trying again after ... I developed Pre E later in pregnancy and delivered at 38+5 and although the thought of getting Preeclampsia again makes me feel ...

*  returning to your OB/GYN for routine stuff - Welcome to the Preeclampsia Foundation

... the situation by finally readmitting me when I developed post-partum pre-eclampsia.. With the next pregnancy, the care was not ... Welcome to the Preeclampsia Foundation Board index Preeclampsia Information HELLP Syndrome Survivors and Underlying Disorders ... Mason born 10.11.10 @ 30+3 wks due to Severe Pre-E. Only lived 2.5 days. Noah born 2.1.12 @ 38 weeks thanks to lots of doctors ... The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times). Looking for recent ...

*  When does baby usually get to come home? - Welcome to the Preeclampsia Foundation

Induction turned emergency c-section due to eclampsia. big healthy toddlers today!. Asa - 10.23.11 at 39 weeks. NO hypertensive ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia After your baby is born ..... ... No HELLP or pre-e! Took LDA starting at week 12 and went off of it at week 38!. http://findingtherainbowconnection.blogspot.com ...

*  doença renal e pré-eclâmpsia Kidney disease and preeclampsia - Welcome to the Preeclampsia Foundation

... is directly related to a poor maternal and perinatal outcomes and increased risk of developing complications such as eclampsia ... Welcome to the Preeclampsia Foundation Board index Preeclampsia Information Saiba mais - Portuguese ... doença renal e pré-eclâmpsia Kidney disease and preeclampsia. * Report this post ... The renal involvement in preeclampsia is associated with podocitopatia. The podocytes are cells in the kidneys that participate ...

*  When to TTC after severe pe and a stillbirth - Welcome to the Preeclampsia Foundation

I lost my baby girl at 24 weeks on 31st May 2012 due to developing severe pre-eclampsia.. When I was discharged from hospital ... Welcome to the Preeclampsia Foundation Board index Life Stages and Preeclampsia Trying Again after Preeclampsia ... Elsie Lily Munday stillborn at 24 weeks 31st May 2012 due to severe pre-eclampsia. Always loved never forgotten. ... Are you considering having another child after preeclampsia? Trying again after preeclampsia can be an emotional challenge. You ...

*  pre-eclampsia

Tagged as: birth, birth story, HELLP, Miscarriage, pre-eclampsia, Pregnancy, secondary infertility, traumatic birth ...

Prenatal nutrition: Nutrition and weight management before and during :pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life.EclampsiaGestational hypertensionAcute fatty liver of pregnancyPlacenta: The placenta (also known as afterbirth) is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, waste elimination, and gas exchange via the mother's blood supply, fight against internal infection and produce hormones to support pregnancy. The placenta provides oxygen and nutrients to growing babies and removes waste products from the baby's blood.Placental abruptionUterus transplantation: The uterine transplant is the surgical procedure whereby a healthy uterus is transplanted into a female organism of which the uterus is absent or diseased. As part of normal mammalian sexual reproduction, a diseased or absent uterus does not allow normal embryonic implantation, effectively rendering the female infertile.Magnesium sulfiteGestational age: Gestational age (or menstrual age) is a measure of the age of a pregnancy where the origin is the woman's last normal menstrual period (LMP), or the corresponding age as estimated by other methods. Such methods include adding 14 days to a known duration since fertilization (as is possible in in vitro fertilization), or by obstetric ultrasonography.Distributing artery: A distributing artery (or muscular artery) is a medium-sized artery that draw blood from an elastic artery and branch into "resistance vessels" including small arteries and arterioles. In contrast to the mechanism elastic arteries use to store energy generated by the heart's contraction, distributing arteries contain layers of smooth muscle.Misattributed paternity: Misattributed paternity is the situation when a child’s putative father is not the child's biological father. Overall, the incidence of misattributed paternity ranges from about 1% to 2%, though it may be considerably higher in certain populations.Trophoblast: Trophoblasts (from Greek trephein: to feed, and blastos: germinator) are cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg.Galectin: Galectins are a family of proteins defined by their binding specificity for β-galactoside sugars, such as N-acetyllactosamine (Galβ1-3GlcNAc or Galβ1-4GlcNAc), which can be bound to proteins by either N-linked or O-linked glycosylation. They are also termed S-type lectins due to their dependency on disulphide bonds for stability and carbohydrate binding.Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Isofuran: Isofurans are nonclassic eicosanoids formed nonenzymatically by free radical mediated peroxidation of arachidonic acid. The isofurans are similar to the isoprostanes and are formed under similar conditions, but contain a substituted tetrahydrofuran ring.Lower segment Caesarean section: A lower (uterine) segment Caesarean section (LSCS) is the most commonly used type of Caesarean section used today. It includes a transverse cut just above the edge of the bladder and results in less blood loss and is easier to repair than other types of Caesarean sections.Sisterhood method: The Sisterhood Method is a household survey to estimate maternal deaths, which includes a series of four questions. The Sisterhood Method is one method recommended by the WHO.Global Alliance to Prevent Prematurity and StillbirthPuerperal disorderQRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Biomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.CardiotocographyTransplacental carcinogenesis: Transplacental carcinogenesis is a series of genotypic and/or phenotypic changes in the cells of a fetus due to in utero exposure to carcinogens. Specifically, these changes are identified as malignant by virtue of their metastatic potential.Hospital of Southern Norway: [[Sørlandet Hospital Arendal, seen from the north.|thumb|200px]]Activin and inhibin: Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified in 1986, activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle.Soluble fms-like tyrosine kinase-1Placental insufficiencyVillitis of unknown etiology: Villitis of unknown etiology, abbreviated VUE, is an inflammatory process that involves the chorionic villi (villitis) whose cause (etiology) is not known. VUE is associated with recurrent miscarriage and intrauterine growth restriction, and recurs in subsequent pregnancies.Superficial velocity: Superficial velocity (or superficial flow velocity), in engineering of multiphase flows and flows in porous media, is a hypothetical (artificial) flow velocity calculated as if the given phase or fluid were the only one flowing or present in a given cross sectional area. Other phases, particles, the skeleton of the porous medium, etc.Decidual reaction: The decidual reaction is the changes in the endometrium of the uterus that prepare it for implantation of an embryo. These changes are observed in each menstrual cycle and enhanced after implantation.Birth weight: Birth weight is the body weight of a baby at its birth.Definitions from Georgia Department of Public Health.

(1/2035) Obstetric and neonatal outcome following chronic hypertension in pregnancy among different ethnic groups.

We retrospectively studied pre-eclampsia rate and obstetric outcome in a cohort of 436 pregnancies amongst 318 women of different ethnic backgrounds attending an antenatal hypertension clinic from 1980-1997, identifying 152 women (213 pregnancies) with chronic essential hypertension. The ethnic breakdown was: White, 64 (30.0%) pregnancies in 48 (31.5%) women; Black/Afro-Caribbean, 79 (37.1%) pregnancies in 56 (36.8%) women; and Indo-Asians, 70 (32.3%) pregnancies in 48 (31.6%) women. The prevalences of pre-eclampsia in White, Black and Indo-Asian women were 17.2%, 12.7% and 18.6%, respectively (p = 0.58). Pregnancies of Indo-Asian women were of shorter gestation, and babies in this group also had lower birth weight and ponderal index compared to those of White and Black women (all p < 0.05). The proportions of overall perinatal mortality were 1.6% for Whites (1/64), 3.8% for Blacks (3/79) and 10.0% for Indo-Asians (7/70), suggesting increased risk in the Indo-Asian group. Indo-Asian women with chronic essential hypertension need careful antenatal care and observation during pregnancy.  (+info)

(2/2035) Maternal second trimester serum tumor necrosis factor-alpha-soluble receptor p55 (sTNFp55) and subsequent risk of preeclampsia.

Preeclampsia is characterized by diffuse vascular endothelial dysfunction. Tumor necrosis factor-alpha (TNF-alpha), which plays a key role in the cytokine network responsible for immunoregulation, is also known to contribute to endothelial dysfunction and other metabolic disturbances noted in preeclampsia. Results from cross-sectional studies and one longitudinal study indicate that TNF-alpha (or its soluble receptor, sTNFp55) is increased in the peripheral circulation and amniotic fluid of women with preeclampsia as compared with normotensive women. Between December 1993 and August 1994, prediagnostic sTNFp55 concentrations (a marker of excessive TNF-alpha release) were measured in 35 women with preeclampsia and 222 normotensive women to determine whether elevations precede the clinical manifestation of the disorder. Logistic regression procedures were used to calculate maximum likelihood estimates of odds ratios and 95% confidence intervals. Mean second trimester (15-22 weeks' gestation) serum sTNFp55 concentrations, measured by enzyme-linked immunosorbent assay, were 14.4% higher in preeclamptic women than in normotensive controls (716.6 pg/ml (standard deviation 193.6) vs. 626.4 pg/ml (standard deviation 158.0); p = 0.003). The relative risk of preeclampsia increased across successively higher quintiles of sTNFp55 (odds ratios were 1.0, 1.3, 2.1, and 3.7, with the lowest quintile used as the referent; p for trend = 0.007). After adjustment for maternal age, adiposity, and parity, the relative risk between extreme quintiles was 3.3 (95% confidence interval 0.8-13.4). These findings indicate that the level of TNF-alpha in maternal circulation is increased prior to the clinical manifestation of the disorder, and they are consistent with the hypothesized role of cytokines in mediating endothelial dysfunction and the pathogenesis of preeclampsia. Further work is needed to identify modifiable risk factors for the excessive synthesis and release of TNF-alpha in pregnancy, and to assess whether lowering of TNF-alpha concentrations in pregnancy alters the incidence and severity of preeclampsia.  (+info)

(3/2035) Outcome of pregnancy in women with congenital shunt lesions.

OBJECTIVE: To evaluate the outcome of pregnancy in women with congenital shunt lesions. SETTING: Retrospective study in a tertiary care centre. METHODS: Pregnancy history was obtained by a standardised questionnaire and medical records were reviewed. PATIENTS: 175 women were identified, at a mean (SD) age of 42 (14) years. Pregnancies occurred in 126 women: 50 with an atrial septal defect, 22 with a ventricular septal defect, 22 with an atrioventricular septal defect, 19 with tetralogy of Fallot, and 13 with other complex shunt lesions. RESULTS: 309 pregnancies were reported by 126 woman (2.5 (1.6) pregnancies per woman). The shortening fraction of the systemic ventricle was 40 (8)%, and 98% were in New York Heart Association class I-II at last follow up. Spontaneous abortions occurred in 17% of pregnancies (abortion rate, 0.4 (0.9) per woman). Gestational age of the 241 newborn infants was 8.8 (0.8) months. There were no maternal deaths related to pregnancy. Pre-eclampsia and embolic events were observed in 1.3% and 0.6%, respectively of all pregnancies. Women with complex shunt lesions more often underwent caesarean section (70% v 15-30%, p = 0.005) and gave birth to smaller babies for equivalent gestation (2577 (671) g v 3016 (572) to 3207 (610) g, p < 0.05). The recurrence risk of congenital heart disease was 2.5%. CONCLUSIONS: The outcome of pregnancy is favourable in women with congenital shunt lesions if their functional class and their systolic ventricular function are good. Such patients can be reassured.  (+info)

(4/2035) Liver disease in pregnancy.

Acute viral hepatitis is the most common cause of jaundice in pregnancy. The course of acute hepatitis is unaffected by pregnancy, except in patients with hepatitis E and disseminated herpes simplex infections, in which maternal and fetal mortality rates are significantly increased. Chronic hepatitis B or C infections may be transmitted to neonates; however, hepatitis B virus transmission is effectively prevented with perinatal hepatitis B vaccination and prophylaxis with hepatitis B immune globulin. Cholelithiasis occurs in 6 percent of pregnancies; complications can safely be treated with surgery. Women with chronic liver disease or cirrhosis exhibit a higher risk of fetal loss during pregnancy. Preeclampsia is associated with HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome, acute fatty liver of pregnancy, and hepatic infarction and rupture. These rare diseases result in increased maternal and fetal mortality. Treatment involves prompt delivery, whereupon the liver disease quickly reverses. Therapy with penicillamine, trientine, prednisone or azathioprine can be safely continued during pregnancy.  (+info)

(5/2035) A strategy for reducing maternal mortality.

A confidential system of enquiry into maternal mortality was introduced in Malaysia in 1991. The methods used and the findings obtained up to 1994 are reported below and an outline is given of the resulting recommendations and actions.  (+info)

(6/2035) Expression of the erythropoietin receptor by trophoblast cellsin the human placenta.

Nonclassical sites of erythropoietin (EPO) and erythropoietin receptor (EPO-R) expression have been described that suggest new physiological roles for this hormone unrelated to erythropoiesis. The recent finding of EPO expression by trophoblast cells in the human placenta prompted us to consider whether these cells also express EPO-R. With use of immunocytochemistry, EPO-R was identified in villous and extravillous cytotrophoblast cells, as well as in the syncytiotrophoblast at all gestational ages. EPO-R was also expressed by cells within the villous core, including endothelial cells of fetoplacental blood vessels. Placental tissues and isolated and immunopurified trophoblast cells, as well as trophoblast-derived choriocarcinoma Jar cells, expressed immunoreactive EPO-R on Western blot. EPO-R mRNA was also detected in the same placental tissues and trophoblast cells by nested-primer reverse transcription-polymerase chain reaction. Finally, EPO-R was functional insofar as the receptor was phosphorylated on tyrosine residues in response to exogenous EPO treatment of cultured trophoblast or Jar cells. Thus, the present findings support the hypothesis that trophoblast cells of the human placenta express EPO-R. In view of these results, taken together with previous work demonstrating EPO expression by the same cells, an autocrine role for this hormone in the survival, proliferation, or differentiation of placental trophoblast cells is proposed.  (+info)

(7/2035) Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.

Immune mechanisms and the renin-angiotensin system are implicated in preeclampsia. We investigated 25 preeclamptic patients and compared them with 12 normotensive pregnant women and 10 pregnant patients with essential hypertension. Antibodies were detected by the chronotropic responses to AT1 receptor-mediated stimulation of cultured neonatal rat cardiomyocytes coupled with receptor-specific antagonists. Immunoglobulin from all preeclamptic patients stimulated the AT1 receptor, whereas immunoglobulin from controls had no effect. The increased autoimmune activity decreased after delivery. Affinity-column purification and anti-human IgG and IgM antibody exposure implicated an IgG antibody directed at the AT1 receptor. Peptides corresponding to sites on the AT1 receptor's second extracellular loop abolished the stimulatory effect. Western blotting with purified patient IgG and a commercially obtained AT1 receptor antibody produced bands of identical molecular weight. Furthermore, confocal microscopy of vascular smooth muscle cells showed colocalization of purified patient IgG and AT1 receptor antibody. The protein kinase C (PKC) inhibitor calphostin C prevented the stimulatory effect. Our results suggest that preeclamptic patients develop stimulatory autoantibodies against the second extracellular AT1 receptor loop. The effect appears to be PKC-mediated. These novel autoantibodies may participate in the angiotensin II-induced vascular lesions in these patients.  (+info)

(8/2035) Color Doppler waveforms of maternal cervical internal carotid arteries in normotensive and preeclamptic gravidas.

The objective of this study was to investigate and determine fitted percentiles of blood flow resistance of cervical internal carotid arteries in normal pregnancies from gestational weeks 20 to 42 and to compare the resistance indices and mean velocities of the these arteries in normotensive and preeclamptic gravidas. A duplex color apparatus with pulsed Doppler ultrasound scanner (7.5 MHz) was used to determine the resistance index and mean velocity values of maternal cervical internal carotid arteries in 310 healthy singleton gravidas (group 1) and 74 singleton preeclamptic gravidas (group 2). The resistance index and mean velocity values of the maternal cervical internal carotid arteries decrease as the gestational age increases in normal gravidas, whereas in preeclamptic pregnancies these values are no different from those in normal gravidas during the second half of the gestational period.  (+info)



severe

  • George said some patients develop preeclampsia later during pregnancy, a condition that's typically less severe since the fetus is more developed. (umc.edu)
  • I lost my baby girl at 24 weeks due to severe pre-eclampsia. (preeclampsia.org)
  • Elsie Lily Munday stillborn at 24 weeks 31st May 2012 due to severe pre-eclampsia. (preeclampsia.org)

pregnant

  • a certain very pregnant character dies from eclampsia . (cafemom.com)
  • Are you pregnant again after having preeclampsia once already in a previous pregnancy? (preeclampsia.org)
  • I had HELLP with my 1st baby which ended in a loss at 21 weeks, I had mild pre-eclampsia with my 2nd pregnant but she is a healthy 2.5 year old now. (preeclampsia.org)
  • Women who have conceived through IVF may be more likely to develop pre-eclampsia during pregnancy than pregnant women who have not, according to a recent study in the US. (bionews.org.uk)
  • Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality worldwide affecting 3% to 5% of pregnant women [ 1 ] and it is associated with the development of cardiovascular disease, obesity, renal damage and diabetes in adults [ 2 - 4 ]. (omicsonline.org)
  • Preeclampsia is more likely to occur in a patient who is pregnant for the first time and happens somewhere between 5-8 percent of all pregnancies, she added. (umc.edu)
  • In some cases we can try to manage the mother conservatively and keep her pregnant, but usually the result of preeclampsia is the need for delivery. (umc.edu)

pregnancy

  • I fervently hope that the future will hold advances that allow us to intervene in a pregnancy identified at risk of preeclampsia and prevent its further development or progression. (acog.org)
  • An ultimate goal is to eliminate fetal, perinatal, and maternal morbidity and mortality caused by preeclampsia and the other hypertensive disorders of pregnancy. (acog.org)
  • I remember during my pregnancy hearing a lot of talk about watching for the signs of preeclampsia. (cafemom.com)
  • A small study has recently suggested that women who use donated eggs in IVF could be at a higher risk of developing pre-eclampsia, a common but potentially dangerous pregnancy complication. (bionews.org.uk)
  • A high number of pre-pregnancy and pregnancy related factors have been associated with PE. (omicsonline.org)
  • Preeclampsia is a disease that occurs in pregnancy and only in pregnancy," said Dr. Sarah Novotny, a maternal-fetal medicine specialist and assistant professor of obstetrics and gynecology at the University of Mississippi Medical Center. (umc.edu)
  • It was her first pregnancy and the new mother-to-be had no idea she was at risk of preeclampsia. (umc.edu)
  • Hypertension associated with preeclampsia develops during pregnancy and remits after delivery, implicating the placenta as a central culprit in the disease. (ahajournals.org)
  • Just remember this: "scaring" a woman will not give her preeclampsia or any other life-threatening condition of pregnancy. (preeclampsia.org)

hypertension

  • The research showed that women who used donor eggs in their treatment were four times more likely than women using their own eggs to get pre-eclampsia , a mostly benign but occasionally serious condition characterised by high blood pressure (hypertension) and protein in the urine. (bionews.org.uk)

weeks

  • It usually starts after 20 weeks gestation, and in the worst cases, it can lead to eclampsia which is seizures. (umc.edu)
  • 2010- Lil' Bro, Pre-E at 29 weeks. (preeclampsia.org)
  • NICE guidelines suggest getting baby out ASAP post 37 weeks if preeclampsia is suspected. (mumsnet.com)

risk

  • The risk of pre-eclampsia after IVF with donated eggs was 11 percent, increased from three percent in other patients. (bionews.org.uk)
  • Also, obesity increases the risk of preeclampsia. (umc.edu)
  • As you can see, we have a lot of risk factors here in Mississippi," said Novotny, adding the condition causes a significant portion of the state's pre-term birth rate. (umc.edu)

Baby

  • 2- Lucas Oliver (rainbow baby)- April 2011, 36+2 wks, HELLP and pre-e free! (preeclampsia.org)
  • The problem with the early onset preeclampsia is it becomes dangerous about the time the baby isn't quite developed enough to deliver," he said. (umc.edu)

percent

  • Nationwide about 15 percent of all premature births are due to preeclampsia. (umc.edu)

likely

  • Doc gave me a mild preeclampsia diagnosis anyway and said I'm likely to be a chronic hypertensive later in life. (preeclampsia.org)

condition

  • But a possible treatment for one of the contributors to these statistics - preeclampsia - could come from the very state impacted the hardest by the condition. (umc.edu)

women

  • Results from ongoing basic and clinical studies, however, should provide new and important information regarding the physiological mechanisms responsible for the elevation in arterial pressure in women with preeclampsia. (ahajournals.org)
  • The mean external diameters of the uterine spiral arteries in women with preeclampsia are less than one half of the diameters of similar vessels from uncomplicated pregnancies. (ahajournals.org)
  • 3 In addition, placentas from women with preeclampsia display an increased frequency of placental infarcts 1,4 and altered morphology evidenced by abnormal cytotrophoblast proliferation and increased formation of syncytial knots. (ahajournals.org)
  • I figure that by her late 30s every woman probably has at least one friend or close relative who's had preeclampsia, but it's surprising how little some women know about it. (preeclampsia.org)
  • I know how hard it is to decide whether or not to bring up the Pre-e with other women. (preeclampsia.org)