Peganum: A plant genus of the family ZYGOPHYLLACEAE. Harmala and other ALKALOIDS, phenylpropanoids, and TRITERPENES have been found in plants of this genus.Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.Zygophyllaceae: A plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida which is a small family of small trees and shrubs growing in arid and warm regions.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.
(1/7) Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test.
PURPOSE: To evaluate the effect of Peganum harmala (Syrian rue) a wild-growing flowering plant belonging to the family Zygophylaceae and found abundantly in Iran on formalin-induced pain response in mice. METHODS: Total alkaloid extract was prepared from dry seeds of Peganum harmala. All doses of extract were dissolved in normal saline and administered intraperitoneally 30 minutes before formalin injection to the mouse paw. Nociception was recorded 0-5 (early phase, A) and 15-40 (late phase, B) minutes after formalin injection. The alkaloid extract was subjected to silica gel column chromatography using a linear gradient with a CHCl3-MeOH system and different fractions collected. The effective fraction in formalin test were further purified and isolated by preparative thin layer chromatography (TLC) and identified on the basis of nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. RESULTS: Alkaloid extract in doses (mg/kg) used induced significant reduction in pain response when compared to control as follow: 16 (28.63%), 20 (59.15%), 24 (80.75%), 28 (90.14%) and 30 (100%) in the early phase and 20 (24.67%), 24 (59.93%), 28 (78.52%) and 30 (100%) in late phase. Observed responses in both phases of A and B were dose-dependent with r2 of 0.93 and 0.99 respectively. ED50 for phases of A and B were 27.87 and 24.63 mg/kg respectively (p<0.001 for all groups). CONCLUSION: Harmaline, the last step of extraction is the main effective antinociceptive agent of the Peganum harmala alkaloid extract. (+info)
(2/7) Treatment of natural tropical theileriosis with the extract of the plant Peganum harmala.
Theileria annulata, a protozoan parasite of cattle and domestic buffaloes, is transmitted by ticks of the genus Hyalomma, and causes a disease named Mediterranean or tropical theileriosis. In this research 50 cattle naturally infected with Theileria annulata were treated with the extract of the plant Peganum harmala. The treatment was continued for 5 days, the dose of the extract being 5 mg/kg per day. After the treatment, 39 cattle responded to the treatment and recovered, but 11 did not respond to the treatment and died. The recovery rate of animals treated with the extract of the plant Peganum harmala was 78%. (+info)
(3/7) Protective effects of estrogens and caloric restriction during aging on various rat testis parameters.
(4/7) Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression.
(5/7) Cytotoxic and insecticidal activities of derivatives of harmine, a natural insecticidal component isolated from Peganum harmala.
(6/7) Recent advances in the studies on luotonins.
(7/7) Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops.