Parotitis: INFLAMMATION of the PAROTID GLAND.Sialography: Radiography of the SALIVARY GLANDS or ducts following injection of contrast medium.Suppuration: A pathologic process consisting in the formation of pus.Mumps: An acute infectious disease caused by RUBULAVIRUS, spread by direct contact, airborne droplet nuclei, fomites contaminated by infectious saliva, and perhaps urine, and usually seen in children under the age of 15, although adults may also be affected. (From Dorland, 28th ed)Mumps virus: The type species of RUBULAVIRUS that causes an acute infectious disease in humans, affecting mainly children. Transmission occurs by droplet infection.Sialadenitis: INFLAMMATION of salivary tissue (SALIVARY GLANDS), usually due to INFECTION or injuries.Sotos Syndrome: Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.
ParotitisRe-sublimityMUMPS users: The United States Veterans Administration was one of the earliest organizations to adopt MUMPS as the programming language for a major project. Their early projects, and contributions to the library of free MUMPS code, are still being used today.Mumps virus: Mumps virus is the causative agent of mumps, a well-known common childhood disease characterised by swelling of the parotid glands, salivary glands and other epithelial tissues, causing high morbidity and in some cases more serious complications such as deafness. Natural infection is currently restricted to humans and the virus is transmitted by direct contact, droplet spread, or contaminated objects.
(1/55) Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections.
We report our experience with linezolid in an investigation of its use against resistant gram-positive bacterial infections. Fifteen patients who had renal failure (n=6), recent liver transplantation (n=5) or surgery (n=6), cancer (n=3), endocarditis (n=2), or human immunodeficiency virus infection (n=1), along with infections due to vancomycin-resistant enterococcus (VRE), and 2 patients with infections due to methicillin-resistant Staphylococcus species who had adverse reactions to vancomycin were treated with linezolid (600 mg every 12 h for 5-42 days (mean+/-SD, 20.5+/-3.5 days). Abscess drainage or prosthetic device removal was undertaken. Microbiological cure occurred in all 10 patients who completed therapy, and all 7 patients alive at follow-up were free of infection. No deaths were attributable to the index infection. Adverse events associated with linezolid use were mild leukopenia in 1 patient and nausea in another. It appears that administration of linezolid, in conjunction with surgical intervention or device removal, is an effective treatment option for serious resistant gram-positive bacterial infections. (+info)
(2/55) Parotid salivary gland dysfunction in chronic graft-versus-host disease (cGVHD): a longitudinal study in a mouse model.
Chronic graft-versus-host disease (cGVHD) is an autoimmune-like phenomenon resulting in morbidity and mortality following allogeneic bone marrow transplantation (BMT). Major salivary gland dysfunction and hyposalivation is one of the prevalent manifestations of cGVHD. We have used the B10.D2 to Balb/C cGVHD mice model in order to assess major salivary gland function in cGVHD, evaluating sialometric, sialochemical and histopathological parameters for almost 3 months. As cGVHD is a chronic debilitating disease it is of vast importance to evaluate these parameters on a prolonged longitudinal basis. We observed significant reduction in parotid salivary flow rate and disturbance in the salivary dynamic function in cGVHD mice in comparison to the normal and syngeneic transplanted controls. On days 18, 25, 46, 56 and 88 the mean flow rates of the cGVHD group were 37.4 +/- 4.4 microl/30 min, 40.5 +/- 4.6 microl/30 min, 32.5 +/- 2.3 microl/30 min, 22.2 +/- 3.2 microl/30 min and 14.8 +/- 3.8 microl/30 min, respectively, values which were lower than those of the syngeneic transplanted controls group by 42% (P < 0.04), 32% (P < 0.03), 44% (P < 0.01), 49% (P < 0.01) and 64% (P < 0.01), respectively. These changes in flow rates were paralleled by changes in the biochemical composition of the saliva. Moreover, the reduction in flow rates correlated with the degree of salivary gland destruction observed in the pathological slides. An inverse correlation was observed between the mean parotid salivary flow rate and the degree of fibrosis observed in the histopathological evaluation of the cGVHD mice (P < 0.01). Maximal flow rate 34.8 +/- 4.6 microl/30 min was observed when no fibrosis was observed while in mice with maximal fibrosis flow rates were minimal. This may point to the pathological mechanism leading to the major salivary gland dysfunction and hyposalivation observed in cGVHD. Thus, it may broaden our knowledge and provide the scientific background for designing better therapeutic strategies for this complication. Bone Marrow Transplantation (2000). (+info)
(3/55) Acute parotitis due to dengue virus.
Acute bilateral parotitis is a common clinical feature of various infectious and autoimmune, metabolic, and drug-related conditions. We describe a unique case of bilateral inflammatory enlargement of the parotid glands in an immunocompetent patient with dengue fever. Evidence of dengue virus in the saliva is also provided for the first time. (+info)
(4/55) Burkholderia pseudomallei--abscess in an unusual site.
Meloidosis in a unusual site has been reported in a child. Complete identification of the organism has been presented. (+info)
(5/55) Outbreak of enteroviral infection in a pediatric hematology-oncology unit.
We review the clinical courses and outcomes of an outbreak of enteroviral infection that occurred in 5 children with acute lymphoblastic leukemia during a 2-month period in a hematology-oncology unit. Three patients presented with encephalitis and 2 with parotitis. Three of the 5 patients recovered uneventfully and 2 died, 1 of chronic encephalitis and 1 of acute brain stem encephalitis. (+info)
(6/55) Recurrent parotitis.
Recurrent parotitis in children is a well described but rare condition of unknown cause. The clinical features of 11 children with recurrent parotitis are described. (+info)
(7/55) SIALADENITIS AND MAJOR SALIVARY GLAND TUMORS IN CHILDREN: EXPERIENCE AT LOS ANGELES CHILDRENS HOSPITAL AND A REVIEW OF THE LITERATURE.
Except for mumps, the benign lesions most frequently seen in the salivary glands of a child are parotitis, hemangioendotheliomas and mixed tumors. Carcinoma and sarcoma are uncommon. Rapid growth and pain are features of malignant change. Chronic parotitis usually subsides under conservative treatment. If operation is necessary, total parotidectomy is advisable. Scout x-ray films and sialangiographic examination are useful in differentiating an inflammatory lesion from a neoplastic growth.The treatment of choice for a non-inflammatory tumor is surgical excision, for most parotid tumors are radioresistant. Small masses should be completely excised for pathological evaluation. Since operation entails risk of damage to the seventh nerve, incisional biopsy may occasionally be indicated in the case of a large diffuse lesion for it is very likely to be benign and operation unnecessary. The risks of seventh nerve damage are magnified in a child as the anatomic structures are smaller and the nerve lies in a more superficial position. (+info)
(8/55) Localization of antigen in tissue cells; antigens of rickettsiae and mumps virus.
Rickettsiae of epidemic typhus fever and Rocky Mountain spotted fever have been microscopically localized and identified in smears of exudates and tissue sections from infected cotton rats by means of homologous antibody labelled with fluorescein. Epidemic typhus has also been identified in smears from single infected human body lice. Mumps virus antigen has been microscopically localized in the parotid of the experimentally infected monkey by the same method. The antigenic material, probably active virus, was found in the cytoplasm of the acinar cells. Such infected acini were scattered irregularly throughout the gland. Some antigen could be seen in the lumens of the parotid ducts and small amounts were present in the cytoplasm of the epithelial cells lining the ducts. (+info)