Optic Neuritis: Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).Neuritis: A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.Neuritis, Autoimmune, Experimental: An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)Optic Nerve: The 2nd cranial nerve which conveys visual information from the RETINA to the brain. The nerve carries the axons of the RETINAL GANGLION CELLS which sort at the OPTIC CHIASM and continue via the OPTIC TRACTS to the brain. The largest projection is to the lateral geniculate nuclei; other targets include the SUPERIOR COLLICULI and the SUPRACHIASMATIC NUCLEI. Though known as the second cranial nerve, it is considered part of the CENTRAL NERVOUS SYSTEM.Neuromyelitis Optica: A syndrome characterized by acute OPTIC NEURITIS; MYELITIS, TRANSVERSE; demyelinating and/or necrotizing lesions in the OPTIC NERVES and SPINAL CORD; and presence of specific autoantibodies to AQUAPORIN 4.Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)Optic Disk: The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve.Evoked Potentials, Visual: The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.Visual Acuity: Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.Vestibular Neuronitis: Idiopathic inflammation of the VESTIBULAR NERVE, characterized clinically by the acute or subacute onset of VERTIGO; NAUSEA; and imbalance. The COCHLEAR NERVE is typically spared and HEARING LOSS and TINNITUS do not usually occur. Symptoms usually resolve over a period of days to weeks. (Adams et al., Principles of Neurology, 6th ed, p304)Optic Atrophy: Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibers which arise in the RETINA and converge to form the OPTIC DISK; OPTIC NERVE; OPTIC CHIASM; and optic tracts. GLAUCOMA; ISCHEMIA; inflammation, a chronic elevation of intracranial pressure, toxins, optic nerve compression, and inherited conditions (see OPTIC ATROPHIES, HEREDITARY) are relatively common causes of this condition.Retinal Ganglion Cells: Neurons of the innermost layer of the retina, the internal plexiform layer. They are of variable sizes and shapes, and their axons project via the OPTIC NERVE to the brain. A small subset of these cells act as photoreceptors with projections to the SUPRACHIASMATIC NUCLEUS, the center for regulating CIRCADIAN RHYTHM.Scotoma: A localized defect in the visual field bordered by an area of normal vision. This occurs with a variety of EYE DISEASES (e.g., RETINAL DISEASES and GLAUCOMA); OPTIC NERVE DISEASES, and other conditions.Aquaporin 4: Aquaporin 4 is the major water-selective channel in the CENTRAL NERVOUS SYSTEM of mammals.Vision Disorders: Visual impairments limiting one or more of the basic functions of the eye: visual acuity, dark adaptation, color vision, or peripheral vision. These may result from EYE DISEASES; OPTIC NERVE DISEASES; VISUAL PATHWAY diseases; OCCIPITAL LOBE diseases; OCULAR MOTILITY DISORDERS; and other conditions (From Newell, Ophthalmology: Principles and Concepts, 7th ed, p132).Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Optic Chiasm: The X-shaped structure formed by the meeting of the two optic nerves. At the optic chiasm the fibers from the medial part of each retina cross to project to the other side of the brain while the lateral retinal fibers continue on the same side. As a result each half of the brain receives information about the contralateral visual field from both eyes.Optic Neuropathy, Ischemic: Ischemic injury to the OPTIC NERVE which usually affects the OPTIC DISK (optic neuropathy, anterior ischemic) and less frequently the retrobulbar portion of the nerve (optic neuropathy, posterior ischemic). The injury results from occlusion of arterial blood supply which may result from TEMPORAL ARTERITIS; ATHEROSCLEROSIS; COLLAGEN DISEASES; EMBOLISM; DIABETES MELLITUS; and other conditions. The disease primarily occurs in the sixth decade or later and presents with the sudden onset of painless and usually severe monocular visual loss. Anterior ischemic optic neuropathy also features optic disk edema with microhemorrhages. The optic disk appears normal in posterior ischemic optic neuropathy. (Glaser, Neuro-Ophthalmology, 2nd ed, p135)Color Perception Tests: Type of vision test used to determine COLOR VISION DEFECTS.Papilledema: Swelling of the OPTIC DISK, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause OPTIC ATROPHY and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)Visual Fields: The total area or space visible in a person's peripheral vision with the eye looking straightforward.Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.Brachial Plexus Neuritis: A syndrome associated with inflammation of the BRACHIAL PLEXUS. Clinical features include severe pain in the shoulder region which may be accompanied by MUSCLE WEAKNESS and loss of sensation in the upper extremity. This condition may be associated with VIRUS DISEASES; IMMUNIZATION; SURGERY; heroin use (see HEROIN DEPENDENCE); and other conditions. The term brachial neuralgia generally refers to pain associated with brachial plexus injury. (From Adams et al., Principles of Neurology, 6th ed, pp1355-6)Color Vision Defects: Defects of color vision are mainly hereditary traits but can be secondary to acquired or developmental abnormalities in the CONES (RETINA). Severity of hereditary defects of color vision depends on the degree of mutation of the ROD OPSINS genes (on X CHROMOSOME and CHROMOSOME 3) that code the photopigments for red, green and blue.Myelitis, Transverse: Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)Optic Nerve Injuries: Injuries to the optic nerve induced by a trauma to the face or head. These may occur with closed or penetrating injuries. Relatively minor compression of the superior aspect of orbit may also result in trauma to the optic nerve. Clinical manifestations may include visual loss, PAPILLEDEMA, and an afferent pupillary defect.Nerve Fibers: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM.Tomography, Optical Coherence: An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.Reflex, Pupillary: Constriction of the pupil in response to light stimulation of the retina. It refers also to any reflex involving the iris, with resultant alteration of the diameter of the pupil. (Cline et al., Dictionary of Visual Science, 4th ed)Encephalomyelitis, Autoimmune, Experimental: An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Visual Field Tests: Method of measuring and mapping the scope of vision, from central to peripheral of each eye.Ophthalmology: A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.Acute Disease: Disease having a short and relatively severe course.Myelin-Oligodendrocyte Glycoprotein: A transmembrane protein present in the MYELIN SHEATH of the CENTRAL NERVOUS SYSTEM. It is one of the main autoantigens implicated in the pathogenesis of MULTIPLE SCLEROSIS.Myelin Proteins: MYELIN-specific proteins that play a structural or regulatory role in the genesis and maintenance of the lamellar MYELIN SHEATH structure.Ophthalmoscopy: Examination of the interior of the eye with an ophthalmoscope.Myelitis: Inflammation of the spinal cord. Relatively common etiologies include infections; AUTOIMMUNE DISEASES; SPINAL CORD; and ischemia (see also SPINAL CORD VASCULAR DISEASES). Clinical features generally include weakness, sensory loss, localized pain, incontinence, and other signs of autonomic dysfunction.Color Perception: Mental processing of chromatic signals (COLOR VISION) from the eye by the VISUAL CORTEX where they are converted into symbolic representations. Color perception involves numerous neurons, and is influenced not only by the distribution of wavelengths from the viewed object, but also by its background color and brightness contrast at its boundary.Visual Pathways: Set of cell bodies and nerve fibers conducting impulses from the eyes to the cerebral cortex. It includes the RETINA; OPTIC NERVE; optic tract; and geniculocalcarine tract.Retinal Neurons: Nerve cells of the RETINA in the pathway of transmitting light signals to the CENTRAL NERVOUS SYSTEM. They include the outer layer of PHOTORECEPTOR CELLS, the intermediate layer of RETINAL BIPOLAR CELLS and AMACRINE CELLS, and the internal layer of RETINAL GANGLION CELLS.Optic Lobe, Nonmammalian: In invertebrate zoology, a lateral lobe of the FOREBRAIN in certain ARTHROPODS. In vertebrate zoology, either of the corpora bigemina of non-mammalian VERTEBRATES. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1329)Stilbamidines: STILBENES with AMIDINES attached.Color Vision: Function of the human eye that is used in bright illumination or in daylight (at photopic intensities). Photopic vision is performed by the three types of RETINAL CONE PHOTORECEPTORS with varied peak absorption wavelengths in the color spectrum (from violet to red, 400 - 700 nm).Vision Tests: A series of tests used to assess various functions of the eyes.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Optic Flow: The continuous visual field seen by a subject through space and time.Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Diagnostic Techniques, Ophthalmological: Methods and procedures for the diagnosis of diseases of the eye or of vision disorders.Myelin Sheath: The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.

*  DMOZ - Health: Conditions and Diseases: Eye Disorders: Optic Nerve: Optic Neuritis

Lists the types of optic nerve disorders and the use of the VER pattern test to diagnose optic neuritis. ... Optic Neuritis Provides general information and details of the main symptoms. Includes a visual interpretation of how the ...

*  Babinski's reflex and Optic neuritis - Symptom Checker - check medical symptoms at RightDiagnosis

List of 57 causes for Babinski's reflex and Optic neuritis, alternative diagnoses, rare causes, misdiagnoses, patient stories, ... Optic neuritis:*Causes: Optic neuritis *Introduction: Optic neuritis *Optic neuritis: Add a 3rd symptom *Optic neuritis: Remove ... Babinski's reflex and Optic neuritis. *Babinski's reflex AND Optic neuritis - Causes of All Symptoms *Babinski's reflex OR ... Babinski's reflex and Optic neuritis and Fatigue (4 causes). *Babinski's reflex and Optic neuritis and Head symptoms (4 causes) ...

*  Optic neuritis | SpringerLink

Patients with signs and symptoms consistent with acute monosymptomatic optic neuritis should undergo evaluation with gadolinium ... Optic Neuritis Study Group: The clinical profile of acute optic neuritis: experience of the Optic Neuritis Treatment Trial. ... Optic Neuritis Study Group: The five-year risk of multiple sclerosis after optic neuritis: experience of the Optic Neuritis ... The Optic Neuritis Study Group: Visual function 5 years after optic neuritis: experience of the Optic Neuritis Treatment Trial ...

*  Optic Neuritis - AAPOS

Optic Neuritis. En Español Read in Chinese What is optic neuritis?. Optic neuritis is inflammation of the optic nerve [See ... What causes optic neuritis?. Optic neuritis is thought to be an autoimmune disorder, in which the immune system mistakenly ... What are the symptoms of optic neuritis?. The first symptom of optic neuritis in a child is most commonly a rapid, often ... What is the prognosis and treatment for optic neuritis?. Fortunately, most children with optic neuritis recover much of their ...

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*  Old cases of optic neuritis? - Multiple Sclerosis - MedHelp

Can old incidences of optic neuritis be detected on exam if you are no longer feeling any symptoms? I assume the damage can be ... Retrobulbar neuritis is actually Retrobulbar Optic Neuritis. The words Optic Neuritis refer to any inflammation on the optic ... Retrobulbar neuritis is actually Retrobulbar Optic Neuritis. The words Optic Neuritis refer to any inflammation on the optic ... Old cases of optic neuritis?. Hey guys, Can old incidences of optic neuritis be detected on exam if you are no longer feeling ...

*  Optic neuritis - Symptoms, Treatments and Resources for Optic neuritis

Treatments and Tools for Optic neuritis. Find Optic neuritis information, treatments for Optic neuritis and Optic neuritis ... MedHelp's Optic neuritis Center for Information, Symptoms, Resources, ... Is it possible to have optic neuritis that DOESN'T leave behind visibly damages optic nerve... ... Just interested to know if anyone else who has had optic neuritis has this effect in their ... ...

*  HELP--optic neuritis pain, but negative on exam.... - Multiple Sclerosis - MedHelp

64% of people with confirmed optic neuritis have a normal exam! Other tests that can confirm the presence of optic neuritis if ... 64% of people with confirmed optic neuritis have a normal exam! Other tests that can confirm the presence of optic neuritis if ... In many cases of optic neuritis - inflammation from an attack on the myelin of the otpic nerve - the optic disc becomes pale. ... In many cases of optic neuritis - inflammation from an attack on the myelin of the otpic nerve - the optic disc becomes pale. ...

*  Optic Neuritis | Reston Hospital Center

Learn more about Optic Neuritis at Reston Hospital Center DefinitionCausesRisk ... In some people, optic neuritis may not cause any visual problems. In those that have them, optic neuritis may cause:. * ... The optic nerve allows you to see by carrying images from your eye to your brain. Optic neuritis involves inflammation of the ... Optic neuritis. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T114935/Optic-neuritis. Updated ...

*  Optic Neuritis Recovery After Oral or IV Corticosteroids - Full Text View - ClinicalTrials.gov

Neuritis. Optic Neuritis. Peripheral Nervous System Diseases. Neuromuscular Diseases. Nervous System Diseases. Optic Nerve ... Recovery of Demyelinating Optic Neuritis After Treatment With Equivalent High Doses of Oral vs. Intravenous Corticosteroids: a ... Optic Neuritis Recovery After Oral or IV Corticosteroids. This study has been completed. ... Patients aged 18-65 with acute demyelinating optic neuritis where treatment with high dose corticosteroids are already been ...

*  Image: Optic neuritis in granulomatous meningoencephalitis, dog - Merck Veterinary Manual

In optic neuritis, the optic nerve head is raised, with blurred margins, variable areas of hemorrhages, and often with adjacent ...

*  Adventures in Autism: H1N1 Vaccine, Optic Neuritis and Disseminated Encephalomyelitis

ADVERSE NEUROLOGIC REACTIONS AFTER BOTH DOSES OF PANDEMIC H1N1 INFLUENZA VACCINE WITH OPTIC NEURITIS AND DEMYELINATION.. ... culminating in bilateral optic neuritis and disseminated encephalomyelitis. A causal association is more likely with repeated ...

*  ICD-9-CM Diagnosis Code 377.3 : Optic neuritis

What: optic neuritis. Optic neuritis: the inflammation, degeneration, or demyelination of the optic nerve. Why: optic neuritis ... neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis) ... patients with optic neuritis present with sudden loss of central vision and pain on moving the eye. Opthalmoscopically there ... Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as multiple sclerosis, ...

*  Vaccine Awakening: Pencil Pushers Deny Vaccine/Optic Neuritis Link

Optic neuritis is a demyelinating inflammation of the optic nerve. Many times development of optic neuritis precedes ... percent of people with optic neuritis could develop MS. I was Dx with optic neuritis on January, thankfully I am know fully ... I developed optic neuritis three days after receiving the flu vaccine. I refuse to believe this is purely coincidental. I have ... After an MRI and Spinal Tap, I was diagnosed with Optic Neuritis and went through hell!! High doses of IV steroids x 3 days-- ...

*  Optic neuritis - Wikipedia

Optic neuritis is a demyelinating inflammation of the optic nerve. It is also known as optic papillitis (when the head of the ... However, for optic neuritis that is not MS-associated (or atypical optic neuritis) the evidence is less clear and therefore the ... Up to 50% of patients with MS will develop an episode of optic neuritis, and 20-30% of the time optic neuritis is the ... frequently there is no abnormal appearance of the nerve head in optic neuritis (in cases of retrobulbar optic neuritis), though ...

*  Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis - Full Text View - ClinicalTrials.gov

Neuritis. Optic Neuritis. Pathologic Processes. Demyelinating Autoimmune Diseases, CNS. Autoimmune Diseases of the Nervous ... Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis (MS-ON). The safety and scientific ... optic neuritis. visual defect. visual loss. relapsing remitting multiple sclerosis (RRMS). primary progressive multiple ... Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: a Pivotal Randomized Double Masked ...

*  A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple...

4. Optic Neuritis Study Group. The clinical profile of optic neuritis. Experience of the optic neuritis treatment trial. Arch ... 7. Hood DC, Odel JG, Zhang X. Tracking the recovery of local optic nerve function after optic neuritis: a multifocal VEP study ... Optic Neuritis (ON), the inflammation and demyelinization of the optic nerve, typically presents with unilateral periorbital ... 2. Halliday AM, McDonald EI, Mushin J. Delayed visual evoked response in optic neuritis. Lancet. 1972;1:661-664. [PubMed] ...

*  Optic Neuritis

download lucky patcher apk Finding an affordable life insurance policy with Optic Neuritis can be quite the challenge. Luckily ... Optic Neuritis. Life Insurance Approval with Optic Neuritis. in Head and Brain ...

*  Optic Neuritis

Inflammation of the optic nerve, can have various causes, and can have a dramatic effect on the quality of vision in the ... Optic Neuritis. The most common cause of a loss of vision in a single eye in a person under age 50 is optic neuritis, an ... Optic Neuritis is the most common initial presentation of Multiple Sclerosis. Should the neuritis recur, or should the patient ... If Optic Neuritis recurrs, then there is again a sudden drop off in vision, with a gradual recovery to near normal vision, but ...

*  Optic Neuritis

... Well, the fun never stops. The past few weeks I've been a hard one to get ahold of, so I thought I'd fill people ... Were you ok flying with optic neuritis? I want to get a flight from the uk to Vegas but worrying the pain will be unbearable. ... But ultimately they got me figured out and I have something called optic neuritis. Basically my immune system got all pissy at ... my optic nerve and decided to tear the myelin covering off of it. The good news: 92% of people who get this recover full vision ...

*  Optic Neuritis - Eye Clinic & Laser Institute

Optic Neuritis. Overview. Optic neuritis refers to swelling or inflammation of the optic nerve. It is often associated with ... In fact, optic neuritis is often the initial sign of MS.. Most patients with optic neuritis experience a sudden onset of ... is the disease most often associated with optic neuritis. It is not uncommon to have an episode of optic neuritis prior to ... Optic neuritis usually affects only one eye and may be a recurring problem with certain diseases such as MS. ...

*  Optic Neuritis / Retinitis Singapore - 65 Doctor Singapore

Colour retinal and optic disc photography. - Colour vision assessment. - Exophthalmometry. - Fundus autofluorescence imaging. ...

*  Optic Neuritis Louisville | Dilated Eye Exam Jeffersonville

Optic Neuritis can cause severe painful eye movements and vision loss. Learn more at Bennett & Bloom Eye Care Centers serving ... Optic Neuritis. What is optic neuritis?. The optic nerve represents the cable connecting the eye to the brain, carrying all of ... How is optic neuritis treated?. Optic neuritis is typically managed with a team of specialists including your eye doctor and a ... During an acute episode of optic neuritis, a person's own immune system attacks this myelin insulation. Optic neuritis is more ...

*  Hyperlipid: 12/01/2012 - 01/01/2013

Multiple Sclerosis and Optic Neuritis (1) * Musing about linoleic acid (1) * NAFLD model based on fish oil (1) ...

*  Oviedo Vision Center - Optometry In Oviedo, FL USA :: Home

Optic Neuritis. *Ocular Rosacea. *Pinguecula and Pterygium (Surfer's Eye). *Presbyopia. *Sjogren's Syndrome ...

Optic neuritisHouse DividedOptic nerve tumor: An optic nerve melanocytoma is a tumor made up of melanocytes and melanin. These tumors are typically a benign; they can grow, but rarely transform into a malignancy.Neuromyelitis opticaList of multiple sclerosis organizations: List of Multiple Sclerosis Organizations in different countries around the worldOptic disc: The optic disc or optic nerve head is the point of exit for ganglion cell axons leaving the eye. BecauseLogMAR chart: A LogMAR chart comprises rows of letters and is used by ophthalmologists and vision scientists to estimate visual acuity. This chart was developed at the National Vision Research Institute of Australia in 1976, and is designed to enable a more accurate estimate of acuity as compared to other charts (e.Berk–Tabatznik syndrome: Berk–Tabatznik syndrome is a condition with an unknown cause that shows symptoms of short stature, congenital optic atrophy and brachytelephalangy. This condition is extremely rare with only two cases being found.ScotomaOperation Eyesight Universal: Operation Eyesight Universal is a Canada-based international development organisation, founded in 1963. It works to prevent avoidable blindness and to cure blindness that is treatable.MethylprednisoloneSensory decussation: The sensory decussation or decussation of the lemniscus is a decussation or crossover of axons from the gracile nucleus and cuneate nucleus, which are responsible for fine touch, proprioception and two-point discrimination of the body. The fibres of this decussation are called the internal arcuate fibres and are found at the superior aspect of the closed medulla superior to the motor decussation.Optic neuropathyFarnsworth Lantern Test: The Farnsworth Lantern Test, or FALANT, is a test of color vision originally developed specifically to screen sailors for shipboard tasks requiring color vision, such as identifying signal lights at night. It screens for red-green deficiencies, but not the much rarer blue color deficiency.PapilledemaMeridian (perimetry, visual field): Meridian (plural: "meridians") is used in perimetry and in specifying visual fields. According to IPS Perimetry Standards 1978 (2002): "Perimetry is the measurement of [an observer's] visual functions ...Demyelinating disease: -, |Monomelic amyotrophy: Monomelic amyotrophy (MMA), also known as Hirayama disease, Sobue disease, juvenile non-progressive amyotrophy and juvenile asymmetric segmental spinal muscular atrophy (JASSMA) — is an untreatable, focal motor neuron disease that primarily affects young (15- to 25-year-old) males in India and Japan. MMA is marked by insidious onset of muscular atrophy, which stabilizes at a plateau after two to five years from which it neither improves nor worsens.Gene therapy for color blindness: Gene therapy for color blindness is an experimental gene therapy aiming to convert congenitally colorblind individuals to trichromats by introducing a photopigment gene that they lack. Though partial color blindness is considered only a mild disability and is controversial whether it is even a disorder, it is a condition that affects many people, particularly males.MyelitisNerve fiber layer: The retinal nerve fiber layer (nerve fiber layer, stratum opticum, RNFL) is formed by the expansion of the fibers of the optic nerve; it is thickest near the porus opticus, gradually diminishing toward the ora serrata.Coherence theory: In physics, coherence theory is the study of optical effects arising from partially coherent light and radio sources. Partially coherent sources are sources where the coherence time or coherence length are limited by bandwidth, by thermal noise, or by other effect.Task-invoked pupillary responseCCL20: Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.HyperintensityRetinal regeneration: Retinal regeneration deals with restoring retinal function to vertebrates so impaired.Plaque-forming unit: In virology, a plaque-forming unit (PFU) is a measure of the number of particles capable of forming plaques per unit volume, such as virus particles. It is a functional measurement rather than a measurement of the absolute quantity of particles: viral particles that are defective or which fail to infect their target cell will not produce a plaque and thus will not be counted.Pediatric ophthalmology: Pediatric ophthalmology is a sub-speciality of ophthalmology concerned with eye diseases, visual development, and vision care in children.Myelin oligodendrocyte glycoprotein: Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system (CNS). In humans this protein is encoded by the MOG gene.Reticulon: Reticulons (RTNs in vertebrates and reticulon-like proteins or RNTls in other eukaryotes) are a group of evolutionary conservative proteins residing predominantly in endoplasmic reticulum, primarily playing a role in promoting membrane curvature. In addition reticulons may play a role in nuclear pore complex formation, vesicle formation, and other processes yet to be defined.Scanning laser ophthalmoscopyHydroxystilbamidineLandolt CAxon guidance: Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach the correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is being researched.Reflected-wave switching: Reflected-wave switching is a signalling technique used in backplane computer buses such as PCI.UCL Institute of NeurologyRemyelination: Remyelination is the process of propagating oligodendrocyte precursor cells to form oligodendrocytes to create new myelin sheaths on demyelinated axons in the CNS. This is a process naturally regulated in the body and tends to be very efficient in a healthy CNS.

(1/359) mtDNA haplogroup J: a contributing factor of optic neuritis.

Optic neuritis frequently occurs in multiple sclerosis (MS), and shares several similarities with the optic neuritis of Leber's hereditary optic neuropathy (LHON), which is mainly due to maternally transmitted mitochondrial DNA (mtDNA) mutations. Our report shows for the first time that a mitochondrial DNA background could influence the clinical expression of MS. One European mtDNA haplogroup was found only in MS patients with optic neuritis but not in MS patients without visual symptoms. Therefore, we hypothesize that mtDNA haplogroup J might constitute a risk factor for optic neuritis occurrence when it is coincidentally associated with MS, but not be a risk factor for developing MS per se as suggested previously.  (+info)

(2/359) Correlation between morphological and functional retinal impairment in multiple sclerosis patients.

PURPOSE: To assess whether a correlation exists between optic nerve fiber layer (NFL) thickness and the retinal or visual pathway function in multiple sclerosis (MS) patients previously affected by optic neuritis. METHODS: Fourteen patients with a diagnosis of definite MS were examined. All had been affected by optic neuritis (MSON) with complete recovery of visual acuity (14 eyes included in study). These were compared with 14 eyes from 14 age-matched control subjects. NFL thickness was measured by optical coherence tomography (OCT). Three different measurements in each quadrant (superior, inferior, nasal, and temporal) were taken and averaged. The data in all quadrants (12 values averaged) were identified as NFL Overall, whereas the data obtained in the temporal quadrant only (3 values averaged) were identified as NFL Temporal. Retinal and visual pathway function was assessed by simultaneously recording pattern electroretinograms (PERGs) and visual evoked potentials (VEPs) using high-contrast (80%) checkerboard stimuli subtending 15 minutes and 60 minutes of the visual arc (min arc) and reversed at the rate of two reversals per second. RESULTS: In MSON eyes there was a significant (P < 0.01) reduction in NFL thickness in both NFL Overall and NFL Temporal evaluations compared with the values observed in control eyes. PERG, (15-min arc checks) and VEP (15-min arc and 60-min arc checks), showed a significant (P < 0.01) delay in latency and reduction in amplitude. NFL Overall and NFL Temporal values were significantly correlated (P < 0.01) to the PERG P50 latency and P50 to N95 amplitude recorded with 15-min arc checks. No correlations (P > 0.01) between NFL values and the other electrophysiological data (PERG recorded with 60-min arc checks and VEP recorded with 15-min arc and 60-min arc checks) were found. CONCLUSIONS: There is a correlation between PERG changes and NFL thickness in MS patients previously affected by optic neuritis, but there is no correlation between VEP changes and NFL thickness.  (+info)

(3/359) Lack of restriction of T cell receptor beta variable gene usage in cerebrospinal fluid lymphocytes in acute optic neuritis.

OBJECTIVES: There have been many studies reporting restricted patterns of T cell receptor usage in established multiple sclerosis and these have led to clinical trials of immunomodulation directed at deleting clonal T cell populations. The present study aims to test the hypothesis that highly restricted T cell populations are also present in the CSF in the earliest clinical stages of acute demyelinating disease of the CNS. METHODS: T cell receptor Vbeta (TCRBV) gene expression was studied in CSF and blood in nine patients with acute optic neuritis within 7 days of onset of symptoms, six patients with an acute relapse of multiple sclerosis, and 13 control subjects. RNA was extracted and cDNA synthesised from unstimulated CSF and blood lymphocytes, and TCRBV gene segments were amplified from the cDNA by polymerase chain reaction (PCR) using 21 family specific primers. PCR products were separated by polyacrylamide gel electrophoresis and detected via a labelled oligonucleotide probe. A semiquantitative analysis of band intensity was performed by laser densitometry. RESULTS: TCRBV mRNA was detected in the CSF of eight of nine patients with optic neuritis, six of six patients with multiple sclerosis, and five of 13 controls, and was closely correlated with the presence of oligoclonal IgG. Usage of a single TCRBV family was demonstrated in two of nine patients with optic neuritis and two of six patients with multiple sclerosis. The number of TCRBV families expressed in the other patients ranged between 5 and 15 (optic neuritis) and 4 and 17 (multiple sclerosis). CONCLUSIONS: There is a relative lack of restriction of TCRBV usage by CSF lymphocytes in the very earliest stages (<7 days) of acute optic neuritis. This may imply either that multiple sclerosis is not a monoclonal disease even at onset, or that the autoimmune response has widened before the disease becomes clinically evident. This may have important consequences for the design of immune therapies in multiple sclerosis. Further studies are required to determine whether the CSF T cell repertoire at presentation has prognostic importance. Longitudinal studies are required to follow the CSF T cell repertoire from the time of presentation and to determine whether it may have prognostic significance.  (+info)

(4/359) Demonstration of Bartonella grahamii DNA in ocular fluids of a patient with neuroretinitis.

We describe the clinical and laboratory features of a 55-year-old human immunodeficiency virus-negative female patient who presented with bilateral intraocular inflammatory disease (neuroretinitis type) and behavioral changes caused by a Bartonella grahamii infection. Diagnosis was based on the PCR analysis of DNA extracted from the intraocular fluids. DNA analysis of the PCR product revealed a 100% identity with the 16S rRNA gene sequence of B. grahamii. The patient was successfully treated with doxycycline (200 mg/day) and rifampin (600 mg/day) for 4 weeks. This is the first report that demonstrates the presence of a Bartonella species in the intraocular fluids of a nonimmunocompromised patient and that indicates that B. grahamii is pathogenic for humans.  (+info)

(5/359) Combined fat- and water-suppressed MR imaging of orbital tumors.

BACKGROUND AND PURPOSE: The use of a high-resolution T2-weighted MR sequence, which suppresses signal from both fat and water, has been shown to be highly effective for depicting areas of inflammatory damage within the optic nerve. The ability of this sequence to show neoplastic and inflammatory orbital lesions, which may mimic neuritis, is unknown. This study was designed to examine the characteristics of such a sequence for the investigation of orbital mass lesions. METHODS: Twenty-eight patients with known or suspected mass lesions of the orbit and six healthy volunteers were recruited for study. Imaging was performed with a 1.5-T MR unit. Participants were examined by selective partial inversion recovery (SPIR) sequences with T2-weighted fast spin-echo acquisition, selective partial inversion recovery/fluid attenuated inversion recovery (SPIR/FLAIR) sequences with fast spin-echo acquisition, short tau inversion recovery (STIR) sequences with fast spin-echo acquisition, and SPIR sequences with contrast-enhanced T1-weighted fast spin-echo acquisition. Two neuroradiologists, using a randomised, blinded method, scored images for lesion presence and extent. Lesion extent was defined as the number of images with visible abnormality, and was compared with the standard of reference established at a later date by consensus review of all imaging sequences. The ability of the sequences to show the presence and extent of pathologic lesions was compared. RESULTS: The SPIR/FLAIR sequence showed both the presence and extent of orbital masses significantly better than did either STIR or T2-weighted SPIR sequences (P<.01 and P<.001, respectively). Contrast-enhanced T1-weighted SPIR images ranked better than SPIR/FLAIR images, although the difference failed to reach statistical significance. In the orbital apex, the SPIR/FLAIR technique was superior to all other techniques used. This reflected its ability to distinguish enhancing, pathologic lesions from enhancing, normal anatomy. CONCLUSION: SPIR/FLAIR is an appropriate screening technique for orbital masses and offers significant advantages over currently used fat-suppressed sequences for the investigation of orbital disease.  (+info)

(6/359) Multiple sclerosis: the disease and its manifestations.

Multiple sclerosis is an immune-mediated inflammatory demyelinating disease of the central nervous system clinically characterized by relapses and remissions of neurological disturbance. A typical relapse, exemplified by optic neuritis, increases in severity over a week or two and after approximately one month begins to remit. Resolution takes place over the course of two to three months. In the early stages, clinical recovery is virtually complete, though persistent abnormalities of conduction can usually be detected by evoked potential techniques and persistent structural abnormalities can be detected by magnetic resonance imaging (MRI). These techniques, together with cerebrospinal fluid examination for oligoclonal IgG, provide supporting evidence for the diagnosis which, in the absence of a specific test, nevertheless remains primarily clinical. The course of the disease is very variable, but after a number of years neurological deficit begins to accumulate after each relapse. In most patients, the relapsing and remitting phase of the disease is followed by a phase of continuous progression of disability. Cognitive disturbances can be detected in many patients even quite early in the course of the illness. Deficits in attention, memory and executive skills may be prominent and tend to become increasingly prominent as neurological deficit increases, although this is not always the case. There is some correlation between the extent of MRI abnormalities in the cerebral white matter and the severity of cognitive deficit. Depression and anxiety are commonly experienced but are poorly correlated to the lesion load seen on MRI. In contrast, the much rarer psychotic symptoms, euphoria and emotional lability are closely linked to the severity of white matter disease.  (+info)

(7/359) Response variability in the visual field: comparison of optic neuritis, glaucoma, ocular hypertension, and normal eyes.

PURPOSE: To compare the relationship between sensitivity and response variability in the visual field of normal eyes and eyes with optic neuritis (ON), glaucoma (POAG), and ocular hypertension (OHT). METHODS: Frequency-of-seeing (FOS) data were collected from four visual field locations in one eye of 71 subjects (12 ON, 25 POAG, 11 OHT, and 23 normal), using a constant stimulus method on an Henson 4000 perimeter (Tinsley Instruments, Croydon, UK). At each location, at least 20 stimuli (subtending 0.5 degrees) were presented for 200 ms at six or more intensities above and below the estimated threshold. The mean and SD of the probit fitted cumulative Normal function were used to estimate sensitivity and response variability. Cluster regression analysis was carried out to determine whether there were differences in the sensitivity-log (variability) relationship between the four groups. RESULTS: Variability was found to increase with decreased sensitivity for all four groups. The combined data from the four groups was well represented (R2 = 0.57) by the function log(e)(SD) = A.sensitivity (dB) + B, where the constants A and B were -0.081 (SE, +/-0.005) and 3.27 (SE, +/-0.15), respectively. Including other statistically significant covariates (false-negative errors, P = 0.004) and factors (diagnosis, P = 0.005) into the model increased the proportion of explained variance to 62% (R2 = 0.62). Stimulus eccentricity (P = 0.34), patient age (P = 0.33), fixation loss rate (P = 0.10), and false-positive rate (P = 0.66) did not reach statistical significance as additional predictors of response variability. CONCLUSIONS: The relationship between response variability and sensitivity is similar for ON, POAG, OHT, and normal eyes. These results provide supporting evidence for the hypothesis that response variability is dependent on functional ganglion cell density.  (+info)

(8/359) Recovery from optic neuritis is associated with a change in the distribution of cerebral response to visual stimulation: a functional magnetic resonance imaging study.

OBJECTIVES: Recovery to normal or near normal visual acuity is usual after acute demyelinating optic neuritis, despite the frequent persistence of conduction abnormalities as evidenced by the visual evoked potential (VEP). This raises the possibility that cortical adaptation to a persistently abnormal input contributes to the recovery process. The objective of this study was to investigate the pattern of cerebral response to a simple visual stimulus in recovered patients in comparison to normal subjects. METHODS: Functional magnetic resonance imaging (fMRI) was used to study the brain activation pattern induced by a periodic monocular 8Hz photic stimulus in seven patients who had recovered from a single episode of acute unilateral optic neuritis, and in seven normal controls. VEPs and structural optic nerve MRI were performed on patients. RESULTS: Stimulation of either eye in controls activated only the occipital visual cortex. However, in patients, stimulation of the recovered eye also induced extensive activation in other areas including the insula-claustrum, lateral temporal and posterior parietal cortices, and thalamus; stimulation of the clinically unaffected eye activated visual cortex and right insula-claustrum only. The volume of extraoccipital activation in patients was strongly correlated with VEP latency (r = 0.71, p = 0.005). CONCLUSIONS: The extraoccipital areas that were activated in patients all have extensive visual connections, and some have been proposed as sites of multimodal sensory integration. The results indicate a functional reorganisation of the cerebral response to simple visual stimuli after optic neuritis that may represent an adaptive response to a persistently abnormal input. Whether this is a necessary part of the recovery process remains to be determined.  (+info)



cases of optic neuritis

  • Old cases of optic neuritis? (medhelp.org)
  • In many cases of optic neuritis - inflammation from an attack on the myelin of the otpic nerve - the optic disc becomes pale. (medhelp.org)
  • Specifically, this term has been suggested for cases of optic neuritis with serological evidence of vasculitis by positive ANA, despite the lack of meeting criteria for SLE. (wikipedia.org)

episode of optic neuritis

  • Up to 50% of patients with MS will develop an episode of optic neuritis, and 20-30% of the time optic neuritis is the presenting sign of MS. The presence of demyelinating white matter lesions on brain MRI at the time of presentation of optic neuritis is the strongest predictor for developing clinically definite MS. Almost half of the patients with optic neuritis have white matter lesions consistent with multiple sclerosis. (wikipedia.org)
  • In the past, a single episode of optic neuritis would not in itself necessarily have been as thoroughly investigated as it would now- the most common cause of optic neuritis is demyelinating disease- Multiple Sclerosis, and doctors were hesitant to give such a serious diagnosis on a one off episode. (mcleishoptometrists.com)
  • It is not uncommon to have an episode of optic neuritis prior to being diagnosed with MS. In fact, optic neuritis is often the initial sign of MS. (youreyeclinic.com)

inflammation

  • Optic neuritis is inflammation of the optic nerve [See figure (aapos.org)
  • This inflammation can cause loss of vision because the optic nerve is crucial for vision. (aapos.org)
  • The attack of the immune system causes inflammation, swelling and impaired function of the optic nerve. (aapos.org)
  • Optic neuritis involves inflammation of the optic nerve. (restonhospital.com)
  • A disorder characterized by inflammation of the optic nerve. (icd9data.com)
  • Inflammation of the optic nerve. (icd9data.com)
  • Optic neuritis: the inflammation, degeneration, or demyelination of the optic nerve. (icd9data.com)
  • Optic neuritis is a demyelinating inflammation of the optic nerve. (blogspot.com)
  • Many times development of optic neuritis precedes development of multiple sclerosis (MS), which is inflammation of the myelin sheath of the brain. (blogspot.com)
  • Inflammation of the optic nerve causes loss of vision, usually because of the swelling and destruction of the myelin sheath covering the optic nerve. (wikipedia.org)
  • Optic Neuritis (ON), the inflammation and demyelinization of the optic nerve, typically presents with unilateral periorbital pain exacerbated by movement, decreased visual acuity, and reduced light and color sensitivity. (pubmedcentralcanada.ca)
  • The most common cause of a loss of vision in a single eye in a person under age 50 is optic neuritis, an inflammation of the optic nerve. (mcleishoptometrists.com)
  • Optic neuritis refers to swelling or inflammation of the optic nerve. (youreyeclinic.com)
  • Inflammation resulting from auto-antibodies, immune complexes, T-cells and complement, probably damages the components of the optic nerve, as well as the blood vessels (vasculitis). (wikipedia.org)
  • Neuromyelitis optica (NMO), also known as Devic's disease or Devic's syndrome, is a heterogeneous condition consisting of the simultaneous inflammation and demyelination of the optic nerve (optic neuritis) and the spinal cord (myelitis). (wikipedia.org)
  • Optic neuritis is inflammation of the optic nerve, which is associated with swelling and destruction of the myelin sheath covering the optic nerve. (wikipedia.org)
  • Optic neuritis-Inflammation of the optic nerve from infection or multiple sclerosis. (wikipedia.org)
  • Stroke or transient ischemic attack Brain tumor Toxocara-A parasitic roundworm that can cause blurred vision Bleeding into the eye Temporal arteritis-Inflammation of an artery in the brain that supplies blood to the optic nerve. (wikipedia.org)

develop optic neuritis

  • Both adults and children have an increased risk of multiple sclerosis if they develop optic neuritis, but children have much less risk. (aapos.org)
  • More than 75 percent of all females who develop optic neuritis go on to develop MS. Multiple sclerosis, which affects more than 1 million people worldwide, is a dreaded chronic disease because it can cause severe deterioration of the brain and block nerve signals that control muscle coordination, strength, sensation and vision. (blogspot.com)
  • Patients with defined SLE that go on to develop optic neuritis should be better identified as lupus optic neuritis. (wikipedia.org)

acute optic

  • Interferon beta 1-a, which has been demonstrated to significantly reduce the 3-year probability of the development of CDMS and the development of clinically silent MRI lesions in high-risk patients with acute optic neuritis, should be considered following IV methylprednisolone treatment (30 mg intramuscularly [IM] weekly). (springer.com)
  • Management of acute optic neuritis. (restonhospital.com)
  • The most common acute optic neuropathy in patients over 50 years of age, NAION has an annual incidence of 2.3-10.2/100,000. (wikipedia.org)

symptoms

  • Patients with signs and symptoms consistent with acute monosymptomatic optic neuritis should undergo evaluation with gadolinium-enhanced MRI of the brain and orbits to determine whether or not they are at high risk for the development of clinically definite multiple sclerosis (CDMS). (springer.com)
  • What are the symptoms of optic neuritis? (aapos.org)
  • Hey guys, Can old incidences of optic neuritis be detected on exam if you are no longer feeling any symptoms? (medhelp.org)
  • Should the neuritis recur, or should the patient have other MS symptoms- such as double vision, limb numbness or weakness, tingling, poor balance or unexplained pain, then more investigations would have been ordered. (mcleishoptometrists.com)
  • The problem may not always be readily apparent by examining the optic nerve, so special attention is paid to the patient's symptoms and other tests. (youreyeclinic.com)
  • Symptoms of optic neuritis in the affected eye include pain on eye movement, sudden loss of vision, and decrease in color vision (especially reds). (wikipedia.org)

DEMYELINATION

  • Optic Neuritis can be caused by demyelination- loss of the insulating support cells surrounding the neurones which form the optic nerve. (mcleishoptometrists.com)
  • It is often associated with diseases causing demyelination (a loss of the protective myelin layer of the the nerve) of the optic nerve, but sometimes the cause is unknown. (youreyeclinic.com)

autoimmune

  • Optic neuritis is thought to be an autoimmune disorder, in which the immune system mistakenly attacks the body's own optic nerve tissue. (aapos.org)
  • Autoimmune optic neuropathy (AON), sometimes called autoimmune optic neuritis, may be a forme fruste of systemic lupus erythematosus (SLE) associated optic neuropathy. (wikipedia.org)
  • AON is more than the presence of any optic neuritis in a patient with an autoimmune process, as it describes a relatively specific clinical syndrome. (wikipedia.org)
  • AQP4+ NMO is currently considered an autoimmune disease (autoimmune astrocytopathy, or autoimmune astrocytic channelopathy) in which a person's own immune system attacks the astrocytes of the optic nerves and spinal cord. (wikipedia.org)

inflammatory optic neuropathy

  • even though in the general case of pathologically confirmed MS there is no correlation isolated optic neuritis or transverse myelitis CRION (Chronic relapsing inflammatory optic neuropathy). (wikipedia.org)
  • It can be classified in: Single isolated optic neuritis (SION) relapsing isolated optic neuritis (RION) chronic relapsing inflammatory optic neuropathy (CRION) the neuromyelitis optica (NMO) spectrum disorder multiple sclerosis associated optic neuritis (MSON) unclassified optic neuritis (UCON) forms. (wikipedia.org)

retinal

  • Opthalmoscopically there may be hyperemia of the optic disc and distention of the large retinal veins. (icd9data.com)
  • These patients have MS-like brain lesions, multifocal spine lesions and retinal and optic nerves atrophy. (wikipedia.org)
  • The process can include bilateral granulomatous anterior uveitis, variable degree of vitritis, thickening of the posterior choroid with elevation of the peripapillary retinal choroidal layer, optic nerve hyperemia and papillitis, and multiple exudative bullous serous retinal detachments. (wikipedia.org)
  • In short, optic atrophy is the end result of any disease that damages nerve cells anywhere between the retinal ganglion cells and the lateral geniculate body (anterior visual system). (wikipedia.org)
  • There are 1.2 million optic nerve fibers that derive from the retinal ganglion cells of the inner retina. (wikipedia.org)

recurrent

  • In all cases of typical acute monosymptomatic demyelinating optic neuritis, oral prednisone alone at a dose of 1 mg/kg per day, without prior treatment with IV methylprednisolone (1 g per day for 3 days), may increase the risk for recurrent optic neuritis, and should be avoided. (springer.com)
  • Recurrent optic neuritis. (wikipedia.org)
  • The main features that differentiate AON from the more common typical demyelinating optic neuritis is the poor recovery of vision and the chronic or recurrent or bilateral course of AON. (wikipedia.org)

ischemic

  • The most common cause is multiple sclerosis or ischemic optic neuropathy (Blood Clot). (wikipedia.org)
  • Under these circumstances, acute ON/MS can be confused with non-arteritic ischemic optic neuropathy (NA-ION). (pubmedcentralcanada.ca)
  • Anterior or retrobulbar ischemic optic neuropathy not associated with pain. (wikipedia.org)
  • In ischemic optic neuropathies, there is insufficient blood flow (ischemia) to the optic nerve. (wikipedia.org)
  • Ischemic optic neuropathies are classified based on the location of the damage and the cause of reduced blood flow, if known. (wikipedia.org)
  • Anterior ischemic optic neuropathy (AION) includes diseases that affect the optic nerve head and cause swelling of the optic disc. (wikipedia.org)
  • Posterior ischemic optic neuropathy is a syndrome of sudden visual loss with optic neuropathy without initial disc swelling with subsequent development of optic atrophy. (wikipedia.org)

retrobulbar neuritis

  • It is also known as optic papillitis (when the head of the optic nerve is involved) and retrobulbar neuritis (when the posterior part of the nerve is involved). (wikipedia.org)
  • Retrobulbar neuritis, an inflamed optic nerve, but with a normal-appearing nerve head, is associated with pain and the other findings of papillitis. (wikipedia.org)

unilateral

  • Other remarkable differences between the presentation of adult optic neuritis as compared to pediatric cases include more often unilateral optic neuritis in adults, while children much predominantly present with bilateral involvement. (wikipedia.org)
  • The clinical features of AON can be variable and present in several unilateral or bilateral forms: Acute anterior or retrobulbar optic neuritis sometimes associated with pain. (wikipedia.org)

neuropathy

  • Approximately 1-2% of patients with defined SLE develop an optic neuropathy during the course of their disease. (wikipedia.org)
  • It may be reasonable to consider that AON pathogenesis represents an incomplete expression of the SLE-associated optic neuropathy disease process. (wikipedia.org)
  • Optic neuropathy refers to damage to the optic nerve due to any cause. (wikipedia.org)
  • Damage and death of these nerve cells, or neurons, leads to characteristic features of optic neuropathy. (wikipedia.org)
  • A pale disc is characteristic of long-standing optic neuropathy. (wikipedia.org)
  • Optic neuropathy is often called optic atrophy, to describe the loss of some or most of the fibers of the optic nerve. (wikipedia.org)
  • In medicine, "atrophy" usually means "shrunken but capable of regrowth", so some argue that "optic atrophy" as a pathological term is somewhat misleading, and the term "optic neuropathy" should be used instead. (wikipedia.org)
  • Radiation optic neuropathy (RON) is also thought to be due to ischemia of the optic nerve that occurs 3 months to 8 or more years after radiation therapy to the brain and orbit. (wikipedia.org)
  • There is also some evidence that interferon treatment (pegylated interferon with ribavirin) for hepatitis C virus can cause optic neuropathy. (wikipedia.org)

lesions

  • Optic neuritis, when combined with the presence of multiple demyelinating white matter brain lesions on MRI, is suspicious for multiple sclerosis. (wikipedia.org)

posterior

  • The anterior optic nerve is supplied by the short posterior ciliary artery and choroidal circulation, while the retrobulbar optic nerve is supplied intraorbitally by a pial plexus, which arises from the ophthalmic artery, internal carotid artery, anterior cerebral artery, and anterior communicating arteries. (wikipedia.org)

damage to the optic nerve

  • 6 , 7 ] recorded mfVEPs from patients with ON/MS and argued that the multifocal visual evoked potential (mfVEP) should be superior to the cVEP in detecting local damage to the optic nerve and retina. (pubmedcentralcanada.ca)

inflammed optic nerve

  • An inflammed optic nerve usually causes a quite dramatic drop in vision in the affected eye, which can come on fairly quickly- over a few hours, and can be accompanied with pain, particularly on eye movements, as the nerve gets tugged around as the eye moves. (mcleishoptometrists.com)

occur

  • Finally Optic Neuritis can occur idiopathically- in many patients who have a single episode, the cause is never established. (mcleishoptometrists.com)
  • Nonneurologic complications of WNV infection that may rarely occur include fulminant hepatitis, pancreatitis, myocarditis, rhabdomyolysis, orchitis, nephritis, optic neuritis and cardiac dysrhythmias and hemorrhagic fever with coagulopathy. (wikipedia.org)
  • Optic neuritis may manifest as visual impairment with decreased visual acuity, although visual field defects, or loss of color vision may occur in isolation or prior to formal loss of acuity. (wikipedia.org)

retina

  • The optic disc is the circle seen and is where the optic nerve enters the back of the eye to spread out around the retina. (medhelp.org)
  • The optic nerve comprises axons that emerge from the retina of the eye and carry visual information to the primary visual nuclei, most of which is relayed to the occipital cortex of the brain to be processed into vision. (wikipedia.org)
  • The optic nerve contains axons of nerve cells that emerge from the retina, leave the eye at the optic disc, and go to the visual cortex where input from the eye is processed into vision. (wikipedia.org)

bilateral

  • We report an unusual case in which neurologic signs occurred in a previously healthy child after both doses of H1N1 2009 influenza vaccine, culminating in bilateral optic neuritis and disseminated encephalomyelitis. (blogspot.com)

sudden

  • How: clinically, patients with optic neuritis present with sudden loss of central vision and pain on moving the eye. (icd9data.com)
  • If Optic Neuritis recurrs, then there is again a sudden drop off in vision, with a gradual recovery to near normal vision, but each recurrence means that the vision is poorer after the attack than before, and over repeated episodes, vision can be permanently reduced. (mcleishoptometrists.com)
  • Most patients with optic neuritis experience a sudden onset of decreased vision along with pain and soreness when moving the eye. (youreyeclinic.com)

symptom

  • The first symptom of optic neuritis in a child is most commonly a rapid, often profound decrease in vision (visual acuity less than 20/400). (aapos.org)
  • Pain with eye movement is a hallmark symptom of optic neuritis. (youreyeclinic.com)

influenza vaccine

  • I hope you see this comment - I found your blog after searching the web for information linking the influenza vaccine to the incidence of optic neuritis. (blogspot.com)

papillitis

  • however, frequently there is no abnormal appearance of the nerve head in optic neuritis (in cases of retrobulbar optic neuritis), though it may be swollen in some patients (anterior papillitis or more extensive optic neuritis). (wikipedia.org)
  • Optic papillitis is a specific type of optic neuritis. (wikipedia.org)

improves

  • In most MS-associated optic neuritis, visual function spontaneously improves over 2-3 months, and there is evidence that corticosteroid treatment does not affect the long term outcome. (wikipedia.org)
  • Optic neuritis characteristically improves over a period of days to weeks. (youreyeclinic.com)

uveitis

  • Optic neuritis associated with adalimumab in the treatment of uveitis. (restonhospital.com)

atypical

  • However, for optic neuritis that is not MS-associated (or atypical optic neuritis) the evidence is less clear and therefore the threshold for treatment with intravenous corticosteroids is lower. (wikipedia.org)
  • Optic neuritis or neuroretinitis is one of the atypical presentations. (wikipedia.org)

Diagnosis

  • Agostoni E, Frigerio R, Protti A. Controversies in optic neuritis pain diagnosis. (restonhospital.com)
  • Bianchi Marzoli S, Martinelli V. Optic neuritis: differential diagnosis. (restonhospital.com)

adults

  • What are the differences between optic neuritis in children and adults? (aapos.org)
  • Children with optic neuritis usually have a history of recent illness or immunization and adults do not. (aapos.org)
  • Optic neuritis in adults and children. (restonhospital.com)

ophthalmologist

  • Can you have optic neuritis NOT VISIBLE to even an ophthalmologist? (medhelp.org)

corticosteroids

  • Practice parameter: the role of corticosteroids in the management of acute monosymptomatic optic neuritis. (springer.com)
  • This Practice Parameter presents a review and classification of literature regarding the use of corticosteroids for the treatment of acute monosymptomatic optic neuritis. (springer.com)
  • Patients aged 18-65 with acute demyelinating optic neuritis where treatment with high dose corticosteroids are already been chosen by the patient and the diagnosing physician will be contacted for screening and enrollment. (clinicaltrials.gov)

patients

  • Why: optic neuritis may be present in patients with sarcoidosis or reiter's syndrome (rarely). (icd9data.com)
  • Many patients with optic neuritis may lose some of their color vision in the affected eye (especially red), with colors appearing subtly washed out compared to the other eye. (wikipedia.org)
  • To compare conventional visual evoked potential (cVEP) and multifocal visual evoked potential (mfVEP) methods in patients with optic neuritis/multiple sclerosis (ON/MS). (pubmedcentralcanada.ca)
  • Since the Optic Neuritis Treatment Trial (ONTT), doctors have discovered that treating patients with intravenous steroid medication (but not oral steroids) reduces the risk of developing MS later on. (youreyeclinic.com)
  • Aim of the study was to investigate the perimetric results in patients with Multiple Sclerosis without optic neuritis. (arvojournals.org)
  • 26 patients with Multiple Sclerosis without optic neuritis (m : f=11 : 15, average age 43.8 ± 9.4 years) were included into the study and compared with age-corresponding controls (n=26, m:f=6:20, average age 40.0 ± 10.3years). (arvojournals.org)
  • In patients with Multiple Sclerosis without optic neuritis we found an in-fluence of the perimetric results. (arvojournals.org)

clinical

  • Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (marcus-gunn pupil), and in some instances optic disc hyperemia and swelling. (icd9data.com)
  • Several causes and clinical courses are possible for the optic neuritis. (wikipedia.org)

uncommon

  • Cranial nerve palsies and optic neuritis are uncommon. (wikipedia.org)

immune system

  • Basically my immune system got all pissy at my optic nerve and decided to tear the myelin covering off of it. (blogspot.com)

treatment

  • What is the prognosis and treatment for optic neuritis? (aapos.org)
  • Optic nerve function assessments will be compared at baseline, prior to treatment, one and six months post corticosteroid treatment. (clinicaltrials.gov)
  • This finding is very significant since approximately 50% of those who experience an initial occurrence of optic neuritis will develop MS. While this treatment has little if any impact on vision, it is important for overall health. (youreyeclinic.com)

prognosis

  • Unlike typical optic neuritis, there is no association with multiple sclerosis, but the visual prognosis for AON is worse than typical optic neuritis. (wikipedia.org)

brain

  • The optic nerve allows you to see by carrying images from your eye to your brain. (restonhospital.com)
  • The optic nerve may also become inflammed if there is an adjacent infection in the meniges (the tissues covering of the brain and central nervous system), orbit (the eye socket) or sinuses- there is an air filled sinus above, between and below the orbit. (mcleishoptometrists.com)

causes

visual

  • Other tests that can confirm the presence of optic neuritis if the optic disc looks normal are an MRI focused on the optic nerve, a VEP, visual field testing and OCT (optic coherence tomography). (medhelp.org)
  • In some people, optic neuritis may not cause any visual problems. (restonhospital.com)
  • It presents with visual loss and signs of optic nerve dysfunction, such as loss of color vision, afferent pupil defect, and sometimes abnormalities of the optic disc. (wikipedia.org)

multiple

  • Risk of developing multiple sclerosis after uncomplicated optic neuritis. (springer.com)
  • The trigger for this immune reaction may be a viral illness, infection around the optic nerve, multiple sclerosis, or other neurological problems. (aapos.org)
  • Optic neuritis in multiple sclerosis. (restonhospital.com)
  • Optic Neuritis is the most common initial presentation of Multiple Sclerosis. (mcleishoptometrists.com)
  • Multiple sclerosis (MS) is the disease most often associated with optic neuritis. (youreyeclinic.com)

nerve function

  • The Eye MD checks vision (which is usually markedly decreased) and evaluates optic nerve function including the pupil reactions, color vision, and peripheral vision. (aapos.org)

onset

  • Many children with optic neuritis have a history of a fever, flu-like illness, or immunizations 1-2 weeks prior to the onset of the decreased vision. (aapos.org)

swollen

  • As the photo demonstrates, the optic nerve becomes swollen and the blood vessels become larger. (aapos.org)

diagnose

  • Optic neuritis may be difficult to diagnose. (restonhospital.com)
  • Lists the types of optic nerve disorders and the use of the VER pattern test to diagnose optic neuritis. (dmoztools.net)