*  Distinct developmental programs require different levels of Bmp signaling during mouse retinal development | Development

Disruption of a Bmp type I receptor gene, Bmpr1a, leads to no detectable eye abnormality. Further reduction of Bmp receptor ... 5A). Gross morphological abnormalities are apparent by E12.5, when double mutant embryos show smaller eyes with a rough margin ... The double null mutant has an anophthalmic phenotype (bottom). (B) Side views of the eyes of E12.5 embryos. Reduced eye size ... heterozygotes show a spectrum of eye abnormalities in the adult (Chang et al., 2001). However, the precise genetic mechanisms ...

*  14 Eye Abnormalities That Signal About Real Issues

The surface of the eye may become gray, dull, or foggy looking. Cloudy eyes is on of the most common types of eye abnormalities ... Changes in Eye Color. The iris of the eye changing color can be a sign that the cells in the eye are being damaged. This may be ... Serious health problems can often be diagnosed by odd signs in the eyes. These 14 eye abnormalities may be a symptom of a real ... If you notice any of these eye abnormalities, they could be a warning sign of a severe issue. Talk to your doctor as soon as ...

*  Best Eye Movement Abnormality Doctor in Chennai, Eye Movement Abnormality Doctors | Credihealth

Get guidance from medical experts to select eye movement abnormality specialist in Chennai from trusted hospitals - credihealth ... Find the best eye movement abnormality doctors in Chennai. ... Best doctors for eye-movement-abnormality in Chennai List of ... List of best Eye Movement Abnormality Doctors from trusted hospitals in Chennai. Get detailed info on educational qualification ... Need help in choosing eye movement abnormality doctor in Chennai? The medical expert will guide you for all hospital needs ...

*  ICD-10 Diagnosis Code H21.562 Pupillary abnormality, left eye

Short Description: Pupillary abnormality, left eye Long Description: Pupillary abnormality, left eye This is the 2018 version ... Eye Diseases Some eye problems are minor and don't last long. But some can lead to a permanent loss of vision. ... 125 - OTHER DISORDERS OF THE EYE WITHOUT MCC. Convert to ICD-9 General Equivalence Map. The ICD-10 and ICD-9 GEMs are used to ... See an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes ...

*  View Lionel Jacques's content in group

Prolonged Space Travel Causes Brain and Eye Abnormalities in Astronauts , SpaceRef - Yo... - 1 views. www.spaceref.com/... ... of the eyes and brains of 27 astronauts who have spent prolonged periods of time in space revealed optical abnormalities ... of the eyes and brains of 27 astronauts who have spent prolonged periods of time in space revealed optical abnormalities ...

*  Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma - Full Text View - ClinicalTrials.gov

Eye Diseases. Eye Abnormalities. Glaucoma, Open-Angle. Congenital Abnormalities. Infant, Newborn, Diseases. ... For failure criterion is assumed: IOP ≤ 5 mmHg or , 21 mm Hg, even with the use of eye drops, need for further surgery, and / ...

*  Assessment of the Prevalence of Genes AHI1, NPHP1 and CEP290 in Joubert Syndrome - Full Text View - ClinicalTrials.gov

Abnormalities, Multiple. Eye Abnormalities. Kidney Diseases, Cystic. Cerebellar Diseases. Coloboma. Polycystic Kidney Diseases ... Congenital Abnormalities. Eye Diseases. Kidney Diseases. Urologic Diseases. Brain Diseases. Central Nervous System Diseases. ... eyes : Leber Congenital Amaurosis, retinopathy, colobomas); liver : hepatic fibrosis; others: polydactyly, tongue hamartomas, ...

*  Long-term Postoperative Outcomes After Bilateral Congenital Cataract Surgery in Eyes With Microphthalmos - Full Text View -...

Long-term Postoperative Outcomes After Bilateral Congenital Cataract Surgery in Eyes With Microphthalmos. The safety and ... Microphthalmos was defined as an eye with an axial length (AL) that is more than 2 SD smaller than the normal for that age ... 72 eyes of 36 patients with microphthalmos who underwent bilateral congenital cataract surgery between January 2003 and June ... Since only a few studies have reported outcomes, and that too only short term of cataract surgery on microphthalmic eyes, in ...

*  Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma - Full Text View -...

Eye Diseases. Eye Abnormalities. Glaucoma, Open-Angle. Congenital Abnormalities. Infant, Newborn, Diseases. ... Any case diagnosed as primary or secondary congenital glaucoma to ocular or systemic abnormalities. ...

*  Lenz Microphthalmia Syndrome - NORD (National Organization for Rare Disorders)

... portions of the eyes (anophthalmia). Such eye abnormalities may result in varying degrees of visual impairment or, in some ... in certain areas of the eye; other eye abnormalities; malformations of the ears, mouth, and/or teeth; digital anomalies; ... Oculo-dento-digital dysplasia is a rare disorder characterized by abnormalities of the facial area, eyes, teeth, and/or fingers ... The degree of visual impairment depends upon the severity and/or combination of eye abnormalities present. ...

*  Soriatane - FDA prescribing information, side effects and uses

... corneal epithelial abnormality, cortical cataract, decreased night vision, diplopia, itchy eyes or eyelids, nuclear cataract, ... Dry eyes. Soriatane may dry your eyes. Wearing contact lenses may be uncomfortable during and after treatment with Soriatane ... The eyes and vision of 329 subjects treated with Soriatane were examined by ophthalmologists. The findings included dry eyes ( ... yellowing of your skin or the whites of your eyes. •. nausea and vomiting. •. loss of appetite. •. dark urine. What are the ...

*  Evaluating the Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2...

Clinically significant eye abnormalities. *A score lower than 28 on the Mini Mental Status Exam (MMSE) ...

*  Common Side Effects of Requip (Ropinirole Hcl) Drug Center - RxList

Eye abnormality. 3. 1. Abnormal vision. 6. 3. Xerophthalmia. 2. 0. a Patients may have reported multiple adverse reactions ...

*  Mycophenolate mofetil, mycophenolic acid: new pregnancy-prevention advice for women and men - GOV.UK

eye abnormalities. *finger malformations. *tracheo-oesophageal malformations. *nervous system malformations, such as spina ...

*  Verazinc - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Eye Abnormalities. *Skin Ulcer. *Wounds And Injuries. How long have you been taking it?. Choose one ...

*  â Mais-Nadim-Nasser Triadâ , A Useful Marker for Leukodystrophies Diagnosis | OMICS International

 % of Eye abnormality. % of Abnormal BERA test.   % of other characteristics. ... No eye contact. Hyper-reflexia was prominent. An ophthalmologist revealed "unlimited range of eye movements", with normal eye ... Inability to make eye contact, with chaotic eye movements (nystagmus) appeared simultaneously with the head droppings. ... The hearing function is also gradually lost, affecting social reactivity of the patient (Tables 1 and 2). The eye movements ...

*  The differential diagnosis of Huntington's disease-like syndromes: 'red flags' for the clinician | Journal of Neurology,...

Eye movement abnormalities. A detailed examination of ocular movements can be very informative. HD patients manifest early ... Finally, it is very important to point out that an early manifestation of 'cerebellar' eye movement abnormalities, for example ... eye movement abnormalities and MRI changes highly similar to HD. Overall, HDL2 should be suspected in every patient of South ... with eye contraversion, after which their eyes follow to the same side in several slow saccades with head thrusts to the point ...

*  prednisolone - UNM Comprehensive Cancer Center

Changes in vision, eye abnormalities. • Swelling, redness or pain in only one extremity. • Rashes or discoloration of skin, ... Abnormalities in wound healing. • Increase in blood sugar levels. What are the less common (occur in 10% to 29% of patients) ...

*  3q deletion Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com

Eye abnormalities *Deformed ears *Delay in growth and development *Blepharophimosis-ptosis-epicanthus inversus syndrome *more ... of chromosome 3 is deleted resulting in various abnormalities which are determined by the size of the deleted portion. More ...

*  2017-07-21 | Ophthalmology Magazine

Among the infants, 24 (21.4%) had eye abnormalities. Ten (41.7%) of the infants with abnormal eye findings did not have ... Two (8.3%) infants with eye abnormalities were born to women infected in the third trimester. Current guidelines recommend eye ... Eye abnormalities may be the initial finding of congenital Zika virus infection, reported Andrea Zin, MD, and co-researchers. ... Most dry eye patients have positive perceptions about the effectiveness of their dry eye treatments, according to Ahmad ...

*  Non-melanoma skin cancer - ONA

Extreme sun sensitivity, neurologic abnormalities, eye abnormalities.. Oculocutaneous albinism. AR, tyrosinase, P-genec, TYRP- ... Pigment decreased-to-absent in skin, hair, and eyes, decreased visual acuity.. ... or eyes. Good functional and cosmetic outcome is an important goal of therapy in these cases and may be facilitated by a ... liver function abnormalities, and severe birth defects. For patients who tolerate retinoids, long-term therapy and laboratory ...

*  Claravis - FDA prescribing information, side effects and uses

... skull abnormality; ear abnormalities (including anotia, micropinna, small or absent external auditory canals); eye ... Documented internal abnormalities include: CNS abnormalities (including cerebral abnormalities, cerebellar malformation, ... Birth defects which have been documented following isotretinoin exposure include abnormalities of the face, eyes, ears, skull, ... Stop using Claravis and call your doctor right away if you develop conjunctivitis (red or inflamed eyes, like "pink eye"), a ...

*  Dr. Jeffrey R Vaninwegen, MD | Ramsey, NJ | Ophthalmologist | Vitals

Eye Abnormalities * Vision Disorders * Cataract Surgery Lens Removal (Capsulorhexis) * Macular Degeneration * Diabetic ... Chronic Dry Eye Facts about chronic dry eye, including the causes, symptoms & doctors. ... Chronic Dry Eye Facts about chronic dry eye, including the causes, symptoms & doctors. ... These doctors are experts on the complicated anatomy of the eye and are trained to treat eye diseases through both medical and ...

*  When Do Feet Have Arches? | PediatricEducation.org™

HEENT showed no obvious eye abnormalities. She had no rashes, or changes in her nails. Neurologically she had good tone and ... The review of systems was negative for fevers, rashes, eye problems, excessive fatigue or lethargy. ... If a child has a significant abnormality such as severe flat feet, real pain, rigidity or other concerns for alternative ... A history of trauma, gait abnormalities or refusal to bear weight should be gathered. ...

*  Slow saccades

Wilson's disease(extremely rare, accompanied by tremor, eye abnormalities). *Cerebellar syndromes *Ataxia telangiectasia ... For vertical eye movements, the MLF appears to primarily carry posterior canal signals and anterior canal derived eye movements ... Cranial nerve palsies - -such as 6th and 3rd nerve palsies usually affect a single eye as well as a subset of eye muscles. ... In internuclear opthalmoplegia, for horizontal movements, the adducting eye is slowed while the abducting eye typically has ...

(1/687) Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis.

Checkpoint mechanisms that respond to DNA damage in the mitotic cell cycle are necessary to maintain the fidelity of chromosome transmission. These mechanisms must be able to distinguish the normal telomeres of linear chromosomes from double-strand break damage. However, on several occasions, Drosophila chromosomes that lack their normal telomeric DNA have been recovered, raising the issue of whether Drosophila is able to distinguish telomeric termini from nontelomeric breaks. We used site-specific recombination on a dispensable chromosome to induce the formation of a dicentric chromosome and an acentric, telomere-bearing, chromosome fragment in somatic cells of Drosophila melanogaster. The acentric fragment is lost when cells divide and the dicentric breaks, transmitting a chromosome that has lost a telomere to each daughter cell. In the eye imaginal disc, cells with a newly broken chromosome initially experience mitotic arrest and then undergo apoptosis when cells are induced to divide as the eye differentiates. Therefore, Drosophila cells can detect and respond to a single broken chromosome. It follows that transmissible chromosomes lacking normal telomeric DNA nonetheless must possess functional telomeres. We conclude that Drosophila telomeres can be established and maintained by a mechanism that does not rely on the terminal DNA sequence.  (+info)

(2/687) Townes-Brocks syndrome.

Townes-Brocks syndrome (TBS) is an autosomal dominant disorder with multiple malformations and variable expression. Major findings include external ear anomalies, hearing loss, preaxial polydactyly and triphalangeal thumbs, imperforate anus, and renal malformations. Most patients with Townes-Brocks syndrome have normal intelligence, although mental retardation has been noted in a few.  (+info)

(3/687) Microdeletion 22q11 and oesophageal atresia.

Oesophageal atresia (OA) is a congenital defect associated with additional malformations in 30-70% of the cases. In particular, OA is a component of the VACTERL association. Since some major features of the VACTERL association, including conotruncal heart defect, radial aplasia, and anal atresia, have been found in patients with microdeletion 22q11.2 (del(22q11.2)), we have screened for del(22q11.2) by fluorescent in situ hybridisation (FISH) in 15 syndromic patients with OA. Del(22q11.2) was detected in one of them, presenting with OA, tetralogy of Fallot, anal atresia, neonatal hypocalcaemia, and subtle facial anomalies resembling those of velocardiofacial syndrome. The occurrence of del(22q11.2) in our series of patients with OA is low (1/15), but this chromosomal anomaly should be included among causative factors of malformation complexes with OA. In addition, clinical variability of del(22q11.2) syndrome is further corroborated with inclusion of OA in the list of the findings associated with the deletion.  (+info)

(4/687) A mutation in the RIEG1 gene associated with Peters' anomaly.

Mutations within the RIEG1 homeobox gene on chromosome 4q25 have previously been reported in association with Rieger syndrome. We report a 3' splice site mutation within the 3rd intron of the RIEG1 gene which is associated with unilateral Peters' anomaly. The mutation is a single base substition of A to T at the invariant -2 site of the 3' splice site. Peters' anomaly, which is characterised by ocular anterior segment dysgenesis and central corneal opacification, is distinct from Rieger anomaly. This is the first description of a RIEG1 mutation associated with Peters' anomaly.  (+info)

(5/687) Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly.

Proper dorsal-ventral patterning in the developing central nervous system requires signals from both the dorsal and ventral portions of the neural tube. Data from multiple studies have demonstrated that bone morphogenetic proteins (BMPs) and Sonic hedgehog protein are secreted factors that regulate dorsal and ventral specification, respectively, within the caudal neural tube. In the developing rostral central nervous system Sonic hedgehog protein also participates in ventral regionalization; however, the roles of BMPs in the developing brain are less clear. We hypothesized that BMPs also play a role in dorsal specification of the vertebrate forebrain. To test our hypothesis we implanted beads soaked in recombinant BMP5 or BMP4 into the neural tube of the chicken forebrain. Experimental embryos showed a loss of the basal telencephalon that resulted in holoprosencephaly (a single cerebral hemisphere), cyclopia (a single midline eye), and loss of ventral midline structures. In situ hybridization using a panel of probes to genes expressed in the dorsal and ventral forebrain revealed the loss of ventral markers with the maintenance of dorsal markers. Furthermore, we found that the loss of the basal telencephalon was the result of excessive cell death and not a change in cell fates. These data provide evidence that BMP signaling participates in dorsal-ventral patterning of the developing brain in vivo, and disturbances in dorsal-ventral signaling result in specific malformations of the forebrain.  (+info)

(6/687) Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene.

Congenital hydrocephalus is an etiologically diverse, poorly understood, but relatively common birth defect. Most human cases are sporadic with familial forms showing considerable phenotypic and etiologic heterogeneity. We have studied the autosomal recessive mouse mutation congenital hydrocephalus ( ch ) to identify candidate human hydrocephalus genes and their modifiers. ch mice have a congenital, lethal hydrocephalus in association with multiple developmental defects, notably skeletal defects, in tissues derived from the cephalic neural crest. We utilized positional cloning methods to map ch in the vicinity of D13Mit294 and confirm that the ch phenotype is caused by homozygosity for a nonsense mutation in a gene encoding a winged helix/forkhead transcription factor ( Mf1 ). Based on linked genetic markers, we performed detailed phenotypic characterization of mutant homozygotes and heterozygotes to demonstrate the pleiotropic effects of the mutant gene. Surprisingly, ch heterozygotes have the glaucoma-related distinct phenotype of multiple anterior segment defects resembling Axenfeld-Rieger anomaly. We also localized a second member of this gene family ( Hfh1 ), a candidate for other developmental defects, approximately 470 kb proximal to Mf1.  (+info)

(7/687) Sprouty, an intracellular inhibitor of Ras signaling.

Sprouty was identified in a genetic screen as an inhibitor of Drosophila EGF receptor signaling. The Egfr triggers cell recruitment in the eye, and sprouty- eyes have excess photoreceptors, cone cells, and pigment cells. Sprouty's function is, however, more widespread. We show that it also interacts genetically with the receptor tyrosine kinases Torso and Sevenless, and it was first discovered through its effect on FGF receptor signaling. In contrast to an earlier proposal that Sprouty is extracellular, we show by biochemical analysis that Sprouty is an intracellular protein, associated with the inner surface of the plasma membrane. Sprouty binds to two intracellular components of the Ras pathway, Drk and Gap1. Our results indicate that Sprouty is a widespread inhibitor of Ras pathway signal transduction.  (+info)

(8/687) wing blister, a new Drosophila laminin alpha chain required for cell adhesion and migration during embryonic and imaginal development.

We report the molecular and functional characterization of a new alpha chain of laminin in Drosophila. The new laminin chain appears to be the Drosophila counterpart of both vertebrate alpha2 (also called merosin) and alpha1 chains, with a slightly higher degree of homology to alpha2, suggesting that this chain is an ancestral version of both alpha1 and alpha2 chains. During embryogenesis, the protein is associated with basement membranes of the digestive system and muscle attachment sites, and during larval stage it is found in a specific pattern in wing and eye discs. The gene is assigned to a locus called wing blister (wb), which is essential for embryonic viability. Embryonic phenotypes include twisted germbands and fewer pericardial cells, resulting in gaps in the presumptive heart and tracheal trunks, and myotubes detached from their target muscle attachment sites. Most phenotypes are in common with those observed in Drosophila laminin alpha3, 5 mutant embryos and many are in common with those observed in integrin mutations. Adult phenotypes show blisters in the wings in viable allelic combinations, similar to phenotypes observed in integrin genes. Mutation analysis in the eye demonstrates a function in rhabdomere organization. In summary, this new laminin alpha chain is essential for embryonic viability and is involved in processes requiring cell migration and cell adhesion.  (+info)



malformations

  • Additional physical abnormalities are often associated with this disorder such as an unusually small head (microcephaly) and/or malformations of the teeth, ears, and/or fingers and/or toes (digits). (rarediseases.org)
  • Most infants with Lenz microphthalmia syndrome also exhibit additional physical abnormalities, such as malformations of the head and facial (craniofacial) area. (rarediseases.org)
  • Coloboma is part of a set of characteristic facies that features craniofacial malformations, such as downslanting eyes, ear anomalies, or hypoplasia of zygomatic bone and jaw (micrognathia). (wikipedia.org)
  • It is associated with brain (lissencephaly, hydrocephalus, cerebellar malformations) and eye abnormalities. (wikipedia.org)
  • causing vomiting and migraines An abnormally shaped uterus (bicornuate) Inability to clot blood efficiently due to a low amount of platelets running through the blood Malformations in the kidney and heart Shortened neck Abnormalities in the urethra When an individual is born with phocomelia due to drugs or pharmaceuticals, it is known as thalidomide syndrome. (wikipedia.org)

retinal abnormalities

  • A malformation of the a baby's cerebellum is often a sign of this disease.Common ocular issues associated with WWS are abnormally small eyes and retinal abnormalities cause by an underdeveloped light-sensitive area in the back of the eye. (wikipedia.org)
  • Aicardi syndrome is a rare genetic malformation syndrome characterized by the partial or complete absence of a key structure in the brain called the corpus callosum, the presence of retinal abnormalities, and seizures in the form of infantile spasms. (wikipedia.org)

skeletal

  • Most males with the disorder also have skeletal abnormalities. (rarediseases.org)
  • Individuals with this syndrome exhibit many physical deformities including skeletal, epidermal, and subcutaneous abnormalities. (wikipedia.org)
  • Due to extensive breeding selection for rapid early growth and the husbandry used to sustain this, broilers are susceptible to several welfare concerns, particularly skeletal malformation and dysfunction, skin and eye lesions, and congestive heart conditions. (wikipedia.org)

ocular abnormalities

  • J Child Neurol 2008;23:531-5 Aicardi J, Lefebvre J, Lerique-Koechlin A. A new syndrome: spasm in flexion, callosal agenesis, ocular abnormalities (abstract). (wikipedia.org)
  • Other ocular abnormalities include ophthalmoplegia (paralysis of one or more of the extraocular muscles) and other types of strabismus, uveitis, and heterochromia of the iris. (wikipedia.org)

cataracts

  • Various eye abnormalities are often seen including lenticonus, keratoconus, cataracts as well as retinal flecks in the macula and mid-periphery. (wikipedia.org)

seizures

  • These features include the ethnic background of the patient, the involvement of the facio-bucco-lingual and cervical district by the movement disorder, the co-occurrence of cerebellar features and seizures, the presence of peculiar gait patterns and eye movement abnormalities, and an atypical progression of illness. (bmj.com)

deafness

  • The letters stand for: coloboma of the eye, heart defects, atresia of the nasal choanae, retardation of growth and/or development, genital and/or urinary abnormalities, and ear abnormalities and deafness. (wikipedia.org)
  • Some eye abnormalities, some heart conditions, and some cases of deafness have been proven to be inherited. (wikipedia.org)

microcephaly

  • Persons with this syndrome have smaller than normal head sizes (microcephaly), are of short stature (dwarfism), their eyes appear sunken, and they have an "aged" look. (wikipedia.org)

ears

  • Since type IV collagen is found in the ears, eyes, and kidneys, this explains why Alport syndrome affects different seemingly unrelated parts of the body (ears, eyes, kidneys, etc. (wikipedia.org)
  • Compared to wolves, many adult dog breeds retain such juvenile characteristics as soft fuzzy fur, round torsos, large heads and eyes, ears that hang down rather than stand erect, etc. (wikipedia.org)
  • Occurrence in an individual results in various abnormalities to the face, limbs, ears, nose, vessels and many other underdevelopments. (wikipedia.org)

neurological

  • Failure to thrive and neurological disorders are criteria for diagnosis, while photosensitivity, hearing loss, eye abnormalities, and cavities are other very common features. (wikipedia.org)
  • Neurological abnormalities are common. (wikipedia.org)

syndrome

  • Lenz Microphthalmia syndrome is an extremely rare inherited disorder characterized by abnormal smallness of one or both eyes (unilateral or bilateral microphthalmos) and/or droopy eyelids (blepharoptosis), resulting in visual impairment. (rarediseases.org)
  • In affected males, the primary physical characteristic associated with Lenz microphthalmia syndrome is abnormal smallness of one or both eyes (unilateral or bilateral microphthalmos). (rarediseases.org)
  • Eye abnormalities have been shown to occur in over 90% of children with fetal alcohol syndrome. (wikipedia.org)
  • Cat eye syndrome, caused by the short arm (p) and a small section of the long arm (q) of human chromosome 22 being present three (trisomic) or four times (tetrasomic) instead of the usual two times. (wikipedia.org)
  • Cockayne syndrome (CS), also called Neill-Dingwall syndrome, is a rare and fatal autosomal recessive neurodegenerative disorder characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), eye disorders and premature aging. (wikipedia.org)
  • Smith-Magenis Syndrome (SMS) is a genetic disorder with features including intellectual disability, facial abnormalities, difficulty sleeping, and numerous behavioral problems such as self-harm. (wikipedia.org)
  • It is a microdeletion syndrome characterized by an abnormality in the short (p) arm of chromosome 17 and is sometimes called the 17p- syndrome. (wikipedia.org)
  • Facial features of children with Smith-Magenis syndrome include a broad face, deep-set eyes, large cheeks, and a prominent jaw, as well as a flat nose bridge. (wikipedia.org)
  • Roughly 45% of people with Parry-Romberg syndrome are also afflicted with trigeminal neuralgia (severe pain in the tissues supplied by the ipsilateral trigeminal nerve, including the forehead, eye, cheek, nose, mouth and jaw) and/or migraine (severe headaches that may be accompanied by visual abnormalities, nausea and vomiting). (wikipedia.org)
  • Enophthalmos (recession of the eyeball within the orbit) is the most common eye abnormality observed in Parry-Romberg syndrome. (wikipedia.org)
  • Alport syndrome can also affect the eyes, though the changes do not usually affect sight, except when changes to the lens occur in later life. (wikipedia.org)
  • In neuroacanthocytosis, acanthocytes are caused by protein but not lipid membrane abnormalities The 'core' neuroacanthocytosis syndromes are chorea acanthocytosis and McLeod syndrome. (wikipedia.org)

congenital

  • 72 eyes of 36 patients with microphthalmos who underwent bilateral congenital cataract surgery between January 2003 and June 2008. (clinicaltrials.gov)
  • Any case diagnosed as primary or secondary congenital glaucoma to ocular or systemic abnormalities. (clinicaltrials.gov)

disorder

  • A rare chromosomal disorder where part of the long arm (q) of chromosome 3 is deleted resulting in various abnormalities which are determined by the size of the deleted portion. (rightdiagnosis.com)
  • Some people with this disorder have ear abnormalities that lead to hearing loss. (wikipedia.org)

facial

  • Hemangioma, the abnormal buildup of blood vessels, will possibly develop around the facial area at birth and the eyes may be set widely apart, a condition known as orbital hypertelorism. (wikipedia.org)

severe

gene

  • Differentiating among these HD-like syndromes is necessary when a patient with a combination of movement disorders, cognitive decline, behavioural abnormalities and progressive disease course proves negative to the genetic testing for HD causative mutations, that is, IT15 gene trinucleotide-repeat expansion. (bmj.com)

colobomas

  • Colobomas may also affect other eye tissues including the ciliary body, choroid, and/or optic disc. (rarediseases.org)
  • The term "cat eye" was coined because of the particular appearance of the vertical colobomas in the eyes of some patients. (wikipedia.org)

occur

  • A coloboma can occur in one eye (unilateral) or both eyes (bilateral). (wikipedia.org)
  • however, various abnormalities can occur to the limbs and bones. (wikipedia.org)

bilateral

  • In our previous study, the investigators examined the intraoperative performance and postoperative outcomes of bilateral cataract surgery in microphthalmic eyes of patients before their first birthday. (clinicaltrials.gov)
  • Since only a few studies have reported outcomes, and that too only short term of cataract surgery on microphthalmic eyes, in this prospective observational study we evaluated the long-term impact of bilateral cataract surgery on eyes with microphthalmos. (clinicaltrials.gov)
  • In most cases, both eyes are affected, and the eyes maybe of different size (bilateral, asymmetrical microphthalmos). (rarediseases.org)

microphthalmia

  • Sometimes, the eye may be reduced in size, a condition called microphthalmia. (wikipedia.org)

absent

  • In addition, some tissue from the colored portion of the eye (iris) may be absent (coloboma), giving the iris a "keyhole" appearance. (rarediseases.org)

Significant

  • Significant abnormalities within the visual system brain structures were found, including alterations of optic radiations, a decrease in white matter concentration, and a reduction of optic chiasm volume. (eyeworld.org)
  • Twenty seven tests were carried out on mutant mice and seven significant abnormalities were observed. (wikipedia.org)

neck

  • The process may eventually extend to involve tissues between the nose and the upper corner of the lip, the upper jaw, the angle of the mouth, the area around the eye and brow, the ear, and/or the neck. (wikipedia.org)

exhibit

  • In rare cases, affected infants may exhibit complete absence of the eyes (anophthalmia). (rarediseases.org)

infantile

  • Cataract surgery in infantile eyes, which are microphthalmic, can be even more demanding. (clinicaltrials.gov)

corneal

  • The investigators examined the outcomes, complication rates, influence of age at surgery on pattern of axial growth and central corneal thickness and visual and orthoptic assessment in these eyes. (clinicaltrials.gov)
  • These authors listed corneal clouding, camptodactyly with hypoplastic nails, and abnormalities of the diaphragm as cardinal features. (wikipedia.org)

Patients

  • Most dry eye patients have positive perceptions about the effectiveness of their dry eye treatments, according to Ahmad Kheirkhah, MD, and co-researchers. (eyeworld.org)
  • They recently evaluated patient perceptions of treatments in dry eye disease among 66 patients. (eyeworld.org)
  • Patients had a comprehensive ophthalmic assessment and used a 10-point scale to score their views on whether dry eye treatments had been effective. (eyeworld.org)
  • The eyes of patients can be affected in various ways and eye abnormalities are common in CS. (wikipedia.org)

loss

  • It may result in double vision, darkened vision, or complete loss of sight in one or both eyes. (theunknownbutnothidden.com)
  • 21 mm Hg, even with the use of eye drops, need for further surgery, and / or loss of light perception. (clinicaltrials.gov)

common

coloboma

  • A coloboma (from the Greek koloboma, meaning defect) is a hole in one of the structures of the eye, such as the iris, retina, choroid, or optic disc. (wikipedia.org)

cause

  • Affected individuals may have eye abnormalities that cause nearsightedness (myopia), strabismus, and other problems with vision. (wikipedia.org)

Cases

  • Such eye abnormalities may result in varying degrees of visual impairment or, in some cases, blindness. (rarediseases.org)
  • Half of these cases are associated with abnormalities in both the gray and white matter of the brain-usually ipsilateral but sometimes contralateral-that are detectable on magnetic resonance imaging (MRI) scan. (wikipedia.org)

movement

  • Need help in choosing eye movement abnormality doctor in Chennai? (credihealth.com)
  • Eye movement abnormalities are also seen. (wikipedia.org)

prominent

  • Some people just have naturally prominent eyes, but be concerned if this is a new physical development. (theunknownbutnothidden.com)

visual

  • At 1 year, the postoperative results showed that good visual outcomes could be obtained in microphthalmic eyes. (clinicaltrials.gov)
  • The degree of visual impairment depends upon the severity and/or combination of eye abnormalities present. (rarediseases.org)

Problems

iris

exposure

  • 50% of affected individuals develop dental abnormalities such as delayed eruption, dental root exposure, or resorption of the dental roots on the affected side. (wikipedia.org)

structures

  • Although operations may improve some abnormalities, many are not surgically treatable due to the lack of nerves and other related structures. (wikipedia.org)

often

However