*  14 Eye Abnormalities That Signal About Real Issues
The surface of the eye may become gray, dull, or foggy looking. Cloudy eyes is on of the most common types of eye abnormalities ... Changes in Eye Color. The iris of the eye changing color can be a sign that the cells in the eye are being damaged. This may be ... Serious health problems can often be diagnosed by odd signs in the eyes. These 14 eye abnormalities may be a symptom of a real ... If you notice any of these eye abnormalities, they could be a warning sign of a severe issue. Talk to your doctor as soon as ...
  http://www.theunknownbutnothidden.com/14-eye-abnormalities-signal-real-issues/
*  Haltiwanger | Biochemistry & Molecular Biology
PPS patients display a number of developmental abnormalities including eye defects, short stature, brachydactyly, cleft palate ... Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep 6: 33974-. PMID:27687499 ... The protein O-glycosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 10: ...
  http://www.bmb.uga.edu/labs/haltiwanger
*  Transcription factor SOX-2
... a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping ... Optic nerve hypoplasia and abnormalities... 1 ×. MGI Term for Transcription factor SOX-2. ...
  https://pharos.nih.gov/idg/targets/P48431
*  Distinct developmental programs require different levels of Bmp signaling during mouse retinal development | Development
Disruption of a Bmp type I receptor gene, Bmpr1a, leads to no detectable eye abnormality. Further reduction of Bmp receptor ... 5A). Gross morphological abnormalities are apparent by E12.5, when double mutant embryos show smaller eyes with a rough margin ... The double null mutant has an anophthalmic phenotype (bottom). (B) Side views of the eyes of E12.5 embryos. Reduced eye size ... heterozygotes show a spectrum of eye abnormalities in the adult (Chang et al., 2001). However, the precise genetic mechanisms ...
  http://dev.biologists.org/content/132/5/913
*  KAKEN - Research Projects | NEURAL CREST CELL AND DEVELOPMENTAL EYE ABNORMALITIES (KAKENHI-PROJECT-09671810)
developmental eye abnormalities / neural crest cells / retinoic acid / mouse fetuses / congenital anomalies / critical period ... Publications] H Ozeki, S Shirai: 'Developmental eye abnormalities in mouse induced by retinoic acid' Japanese Jounal of ... Publications] Hironori Ozeki: 'Developmental eye abnormalities in mouse fetuses induced by retinoic acid' Japanese Journal of ... Publications] Hironori Ozeki: 'Critical time for developmental eye abnormalities induced by retinoic acid in mouse fetuses' ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09671810/
*  bryan's blog: My eye abnormalities - part 2
My right eye adds a red-ish tint to everything, while everything out of my left eye looks more blue-ish. I only really notice ... Anna mentioned this to me today and I said 'Yeah, left eyes have more blue and right eyes have more red.' I didn't know that it ... Here's another thing about my eyes that are weird: I see different colors out of each eye. It's actually very subtle and I ... I can see (haha-play on words) that the genetic researchers are going to have a grand time with the Lewis kids' eyes.. Soda. ...
  http://bryangregorylewis.blogspot.com/2012/11/my-eye-abnormalities-part-2.html
*  Leicester Research Archive: [Eye movement abnormalities as a sign for the diagnosis in Niemann-Pick disease type C].
The eye movement abnormalities in our two patients were suggestive of Niemann Pick disease type C, characterized by initial ... Eye movement abnormalities in familial mental retardation syndrome should lead to the suspicion of a storage disorder, ... Eye movement abnormalities as a sign for the diagnosis in Niemann-Pick disease type C].. ... The characteristics of eye movements in storage disorders are different. In Gaucher's disease a progressive horizontal gaze ...
  https://lra.le.ac.uk/handle/2381/22734
*  Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens - Full Text View - ClinicalTrials.gov
Eye Abnormalities. Vascular Diseases. Cardiovascular Diseases. Eye Diseases. Eye Diseases, Hereditary. Iris Diseases. Uveal ... Abnormalities of the Eye's Anterior Chamber, Iris, Cornea and Lens. The safety and scientific validity of this study is the ... This study will investigate congenital or developmental eye abnormalities that affect the iris, cornea and lens, and are ... A small instrument (tonometer) is placed on the surface of one eye, and with the other eye, the patient looks at an overhead ...
  https://clinicaltrials.gov/ct2/show/NCT00001161
*  change your eye color naturally - 28 images - 14 eye abnormalities that signal about real issues, how to change your eye color...
... how to change your eye color naturally, can you naturally change your eye color on the hunt, how to change your eye color ... change eye colour photoshop skandy photoshop tutorials, here is how you can change your eye color in a completely, ... can you naturally change your eye color on the hunt. loading.... How To Lighten Your With Honey Brown Hairs, Change Your Eye ... How To Change Your Eye Color Naturally At Home To Blue, Can You Naturally Change Your Eye Color On The Hunt, Here Is How You ...
  http://www.inglewoodculturalarts.org/change-your-eye-color-naturally.html
*  Abnormalities of nonvisually-guided eye movements in Parkinson's Disease - Research Portal | Lancaster University
Abnormalities of nonvisually-guided eye movements in Parkinson's Disease. Research output: Contribution to journal › Journal ... Eye movements directly elicited by a novel peripheral target were unimpaired in patients with PD as compared with control ... Rapid eye movements (saccades) were examined in 7 patients with idiopathic Parkinson's disease (PD) and a matched group of ... The PD impairment was not caused by a loss of information on target location since their final eye position was close to the ...
  http://www.research.lancs.ac.uk/portal/en/publications/abnormalities-of-nonvisuallyguided-eye-movements-in-parkinsons-disease
*  Best Eye Movement Abnormality Doctor in Chennai, Eye Movement Abnormality Doctors | Credihealth
Get guidance from medical experts to select eye movement abnormality specialist in Chennai from trusted hospitals - credihealth ... Find the best eye movement abnormality doctors in Chennai. ... Best doctors for eye-movement-abnormality in Chennai List of ... List of best Eye Movement Abnormality Doctors from trusted hospitals in Chennai. Get detailed info on educational qualification ... Need help in choosing eye movement abnormality doctor in Chennai? The medical expert will guide you for all hospital needs ...
  https://www.credihealth.com/doctors/chennai/eye-movement-abnormality
*  ICD-10 Diagnosis Code H21.562 Pupillary abnormality, left eye
Short Description: Pupillary abnormality, left eye Long Description: Pupillary abnormality, left eye This is the 2018 version ... Eye Diseases Some eye problems are minor and don't last long. But some can lead to a permanent loss of vision. ... 125 - OTHER DISORDERS OF THE EYE WITHOUT MCC. Convert to ICD-9 General Equivalence Map. The ICD-10 and ICD-9 GEMs are used to ... See an eye care professional right away if you have a sudden change in vision, if everything looks dim, or if you see flashes ...
  https://icdlist.com/icd-10/h21562
*  Pregnancy Outcomes After Maternal Zika Virus Infection During Pregnancy - U.S. Territories, January 1, 2016-April 25, 2017 |...
with brain abnormalities and/or microcephaly¶ No. with NTDs and early brain malformations, eye abnormalities, or consequence of ... brain abnormalities and/or microcephaly and 2) neural tube defects, eye abnormalities, or consequences of central nervous ... eye abnormality, or consequence of central nervous system dysfunction.. § Infant specimens include serum, urine, and ... eye abnormalities; and consequences of central nervous system dysfunction, such as joint contractures and congenital ...
  https://www.cdc.gov/mmwr/volumes/66/wr/mm6623e1.htm
*  View Lionel Jacques's content in group
Prolonged Space Travel Causes Brain and Eye Abnormalities in Astronauts , SpaceRef - Yo... - 1 views. www.spaceref.com/... ... of the eyes and brains of 27 astronauts who have spent prolonged periods of time in space revealed optical abnormalities ... of the eyes and brains of 27 astronauts who have spent prolonged periods of time in space revealed optical abnormalities ...
  https://groups.diigo.com/group/advanced-concepts-team/content/user/lioneljacques
*  Signs of Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye and Early Lethality - RightDiagnosis.com
Anomalies of the Eye and Early Lethality signs or Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye ... Segment Anomalies of the Eye and Early Lethality including medical signs and symptoms of Multiple Skeletal abnormalities with ... and the correct diagnosis for Multiple Skeletal abnormalities with Anterior Segment ... Anterior Segment Anomalies of the Eye and Early Lethality, symptoms, misdiagnosis, tests, common medical issues, duration, ...
  http://www.rightdiagnosis.com/m/multiple_skeletal_abnormalities_with_anterior_segment_anomalies_of_the_eye_and_early_lethality/signs.htm
*  Causes of Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye and Early Lethality - RightDiagnosis.com
... hidden medical causes of Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye and Early Lethality, risk ... and what causes Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye and Early Lethality. ... Causes of Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye and Early Lethality including triggers, ... Causes of Broader Categories of Multiple Skeletal abnormalities with Anterior Segment Anomalies of the Eye and Early Lethality: ...
  http://www.rightdiagnosis.com/m/multiple_skeletal_abnormalities_with_anterior_segment_anomalies_of_the_eye_and_early_lethality/causes.htm
*  Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma - Full Text View - ClinicalTrials.gov
Eye Diseases. Eye Abnormalities. Glaucoma, Open-Angle. Congenital Abnormalities. Infant, Newborn, Diseases. ... For failure criterion is assumed: IOP ≤ 5 mmHg or , 21 mm Hg, even with the use of eye drops, need for further surgery, and / ...
  https://clinicaltrials.gov/show/NCT01494974
*  Assessment of the Prevalence of Genes AHI1, NPHP1 and CEP290 in Joubert Syndrome - Full Text View - ClinicalTrials.gov
Abnormalities, Multiple. Eye Abnormalities. Kidney Diseases, Cystic. Cerebellar Diseases. Coloboma. Polycystic Kidney Diseases ... Congenital Abnormalities. Eye Diseases. Kidney Diseases. Urologic Diseases. Brain Diseases. Central Nervous System Diseases. ... eyes : Leber Congenital Amaurosis, retinopathy, colobomas); liver : hepatic fibrosis; others: polydactyly, tongue hamartomas, ...
  https://clinicaltrials.gov/ct2/show/NCT00873678
*  Long-term Postoperative Outcomes After Bilateral Congenital Cataract Surgery in Eyes With Microphthalmos - Full Text View -...
Long-term Postoperative Outcomes After Bilateral Congenital Cataract Surgery in Eyes With Microphthalmos. The safety and ... Microphthalmos was defined as an eye with an axial length (AL) that is more than 2 SD smaller than the normal for that age ... 72 eyes of 36 patients with microphthalmos who underwent bilateral congenital cataract surgery between January 2003 and June ... Since only a few studies have reported outcomes, and that too only short term of cataract surgery on microphthalmic eyes, in ...
  https://clinicaltrials.gov/ct2/show/NCT01818037?term=cataract&rank=3
*  Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma - Full Text View -...
Eye Diseases. Eye Abnormalities. Glaucoma, Open-Angle. Congenital Abnormalities. Infant, Newborn, Diseases. ... Any case diagnosed as primary or secondary congenital glaucoma to ocular or systemic abnormalities. ...
  https://www.clinicaltrials.gov/ct2/show/NCT01460017
*  Genetics of Uveal Coloboma - Full Text View - ClinicalTrials.gov
They will also have a full eye exam.. *Participants with uveal coloboma may have other exams, such as imaging studies and ... Uveal coloboma is a condition where the eye does not form normally. It occurs early in the fetus s development during pregnancy ... It can lead to different kinds of eye problems, including blindness. Several genes have been linked to coloboma, but the cause ... Keywords provided by National Institutes of Health Clinical Center (CC) ( National Eye Institute (NEI) ): ...
  https://clinicaltrials.gov/ct2/show/NCT01778543
*  Lenz Microphthalmia Syndrome - NORD (National Organization for Rare Disorders)
... portions of the eyes (anophthalmia). Such eye abnormalities may result in varying degrees of visual impairment or, in some ... in certain areas of the eye; other eye abnormalities; malformations of the ears, mouth, and/or teeth; digital anomalies; ... Oculo-dento-digital dysplasia is a rare disorder characterized by abnormalities of the facial area, eyes, teeth, and/or fingers ... The degree of visual impairment depends upon the severity and/or combination of eye abnormalities present. ...
  https://rarediseases.org/rare-diseases/lenz-microphthalmia-syndrome/
*  Soriatane - FDA prescribing information, side effects and uses
... corneal epithelial abnormality, cortical cataract, decreased night vision, diplopia, itchy eyes or eyelids, nuclear cataract, ... Dry eyes. Soriatane may dry your eyes. Wearing contact lenses may be uncomfortable during and after treatment with Soriatane ... The eyes and vision of 329 subjects treated with Soriatane were examined by ophthalmologists. The findings included dry eyes ( ... yellowing of your skin or the whites of your eyes. •. nausea and vomiting. •. loss of appetite. •. dark urine. What are the ...
  https://www.drugs.com/pro/soriatane.html
*  Kansas City, Missouri | Club LuckKansas City, Missouri - Club Luck
Your eyes are just as beautiful as his. He does color outside the lines every now and again but that is alright with me. My ... I was born and still live with the congenital(pre-birth existing) spinal anomaly/abnormality Spina Bifida Myelemeningocele and ... Reading this story brought tears to the eyes and a great big grin to the lips of this 31 year old man. It brought back so many ... I just wished he could of seen my blue eyes crying in the rain. Never heard roll me up and smoke me….I completely understand ...
  http://www.willienelson.com/story/kansas-city-missouri/?replytocom=354237

(1/687) Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis.

Checkpoint mechanisms that respond to DNA damage in the mitotic cell cycle are necessary to maintain the fidelity of chromosome transmission. These mechanisms must be able to distinguish the normal telomeres of linear chromosomes from double-strand break damage. However, on several occasions, Drosophila chromosomes that lack their normal telomeric DNA have been recovered, raising the issue of whether Drosophila is able to distinguish telomeric termini from nontelomeric breaks. We used site-specific recombination on a dispensable chromosome to induce the formation of a dicentric chromosome and an acentric, telomere-bearing, chromosome fragment in somatic cells of Drosophila melanogaster. The acentric fragment is lost when cells divide and the dicentric breaks, transmitting a chromosome that has lost a telomere to each daughter cell. In the eye imaginal disc, cells with a newly broken chromosome initially experience mitotic arrest and then undergo apoptosis when cells are induced to divide as the eye differentiates. Therefore, Drosophila cells can detect and respond to a single broken chromosome. It follows that transmissible chromosomes lacking normal telomeric DNA nonetheless must possess functional telomeres. We conclude that Drosophila telomeres can be established and maintained by a mechanism that does not rely on the terminal DNA sequence.  (+info)

(2/687) Townes-Brocks syndrome.

Townes-Brocks syndrome (TBS) is an autosomal dominant disorder with multiple malformations and variable expression. Major findings include external ear anomalies, hearing loss, preaxial polydactyly and triphalangeal thumbs, imperforate anus, and renal malformations. Most patients with Townes-Brocks syndrome have normal intelligence, although mental retardation has been noted in a few.  (+info)

(3/687) Microdeletion 22q11 and oesophageal atresia.

Oesophageal atresia (OA) is a congenital defect associated with additional malformations in 30-70% of the cases. In particular, OA is a component of the VACTERL association. Since some major features of the VACTERL association, including conotruncal heart defect, radial aplasia, and anal atresia, have been found in patients with microdeletion 22q11.2 (del(22q11.2)), we have screened for del(22q11.2) by fluorescent in situ hybridisation (FISH) in 15 syndromic patients with OA. Del(22q11.2) was detected in one of them, presenting with OA, tetralogy of Fallot, anal atresia, neonatal hypocalcaemia, and subtle facial anomalies resembling those of velocardiofacial syndrome. The occurrence of del(22q11.2) in our series of patients with OA is low (1/15), but this chromosomal anomaly should be included among causative factors of malformation complexes with OA. In addition, clinical variability of del(22q11.2) syndrome is further corroborated with inclusion of OA in the list of the findings associated with the deletion.  (+info)

(4/687) A mutation in the RIEG1 gene associated with Peters' anomaly.

Mutations within the RIEG1 homeobox gene on chromosome 4q25 have previously been reported in association with Rieger syndrome. We report a 3' splice site mutation within the 3rd intron of the RIEG1 gene which is associated with unilateral Peters' anomaly. The mutation is a single base substition of A to T at the invariant -2 site of the 3' splice site. Peters' anomaly, which is characterised by ocular anterior segment dysgenesis and central corneal opacification, is distinct from Rieger anomaly. This is the first description of a RIEG1 mutation associated with Peters' anomaly.  (+info)

(5/687) Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly.

Proper dorsal-ventral patterning in the developing central nervous system requires signals from both the dorsal and ventral portions of the neural tube. Data from multiple studies have demonstrated that bone morphogenetic proteins (BMPs) and Sonic hedgehog protein are secreted factors that regulate dorsal and ventral specification, respectively, within the caudal neural tube. In the developing rostral central nervous system Sonic hedgehog protein also participates in ventral regionalization; however, the roles of BMPs in the developing brain are less clear. We hypothesized that BMPs also play a role in dorsal specification of the vertebrate forebrain. To test our hypothesis we implanted beads soaked in recombinant BMP5 or BMP4 into the neural tube of the chicken forebrain. Experimental embryos showed a loss of the basal telencephalon that resulted in holoprosencephaly (a single cerebral hemisphere), cyclopia (a single midline eye), and loss of ventral midline structures. In situ hybridization using a panel of probes to genes expressed in the dorsal and ventral forebrain revealed the loss of ventral markers with the maintenance of dorsal markers. Furthermore, we found that the loss of the basal telencephalon was the result of excessive cell death and not a change in cell fates. These data provide evidence that BMP signaling participates in dorsal-ventral patterning of the developing brain in vivo, and disturbances in dorsal-ventral signaling result in specific malformations of the forebrain.  (+info)

(6/687) Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene.

Congenital hydrocephalus is an etiologically diverse, poorly understood, but relatively common birth defect. Most human cases are sporadic with familial forms showing considerable phenotypic and etiologic heterogeneity. We have studied the autosomal recessive mouse mutation congenital hydrocephalus ( ch ) to identify candidate human hydrocephalus genes and their modifiers. ch mice have a congenital, lethal hydrocephalus in association with multiple developmental defects, notably skeletal defects, in tissues derived from the cephalic neural crest. We utilized positional cloning methods to map ch in the vicinity of D13Mit294 and confirm that the ch phenotype is caused by homozygosity for a nonsense mutation in a gene encoding a winged helix/forkhead transcription factor ( Mf1 ). Based on linked genetic markers, we performed detailed phenotypic characterization of mutant homozygotes and heterozygotes to demonstrate the pleiotropic effects of the mutant gene. Surprisingly, ch heterozygotes have the glaucoma-related distinct phenotype of multiple anterior segment defects resembling Axenfeld-Rieger anomaly. We also localized a second member of this gene family ( Hfh1 ), a candidate for other developmental defects, approximately 470 kb proximal to Mf1.  (+info)

(7/687) Sprouty, an intracellular inhibitor of Ras signaling.

Sprouty was identified in a genetic screen as an inhibitor of Drosophila EGF receptor signaling. The Egfr triggers cell recruitment in the eye, and sprouty- eyes have excess photoreceptors, cone cells, and pigment cells. Sprouty's function is, however, more widespread. We show that it also interacts genetically with the receptor tyrosine kinases Torso and Sevenless, and it was first discovered through its effect on FGF receptor signaling. In contrast to an earlier proposal that Sprouty is extracellular, we show by biochemical analysis that Sprouty is an intracellular protein, associated with the inner surface of the plasma membrane. Sprouty binds to two intracellular components of the Ras pathway, Drk and Gap1. Our results indicate that Sprouty is a widespread inhibitor of Ras pathway signal transduction.  (+info)

(8/687) wing blister, a new Drosophila laminin alpha chain required for cell adhesion and migration during embryonic and imaginal development.

We report the molecular and functional characterization of a new alpha chain of laminin in Drosophila. The new laminin chain appears to be the Drosophila counterpart of both vertebrate alpha2 (also called merosin) and alpha1 chains, with a slightly higher degree of homology to alpha2, suggesting that this chain is an ancestral version of both alpha1 and alpha2 chains. During embryogenesis, the protein is associated with basement membranes of the digestive system and muscle attachment sites, and during larval stage it is found in a specific pattern in wing and eye discs. The gene is assigned to a locus called wing blister (wb), which is essential for embryonic viability. Embryonic phenotypes include twisted germbands and fewer pericardial cells, resulting in gaps in the presumptive heart and tracheal trunks, and myotubes detached from their target muscle attachment sites. Most phenotypes are in common with those observed in Drosophila laminin alpha3, 5 mutant embryos and many are in common with those observed in integrin mutations. Adult phenotypes show blisters in the wings in viable allelic combinations, similar to phenotypes observed in integrin genes. Mutation analysis in the eye demonstrates a function in rhabdomere organization. In summary, this new laminin alpha chain is essential for embryonic viability and is involved in processes requiring cell migration and cell adhesion.  (+info)



  • development
  • Some people just have naturally prominent eyes, but be concerned if this is a new physical development. (theunknownbutnothidden.com)
  • Vertebrate eye development proceeds through a series of inductive processes involving multiple tissue components and has been studied as a model system to explore the general mechanisms underlying embryonic tissue interactions ( Jacobson and Sater, 1988 ). (biologists.org)
  • Several families of secreted signaling molecules including the bone morphogenetic protein (Bmp) family are implicated in the control of inductive processes during normal eye development ( Chow and Lang, 2001 ). (biologists.org)
  • Previous studies have implicated at least two members of the Bmp gene family, Bmp4 and Bmp7 , in mouse eye development. (biologists.org)