Alopecia: Absence of hair from areas where it is normally present.
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Globosides: Glycosphingolipids containing N-acetylglucosamine (paragloboside) or N-acetylgalactosamine (globoside). Globoside is the P antigen on erythrocytes and paragloboside is an intermediate in the biosynthesis of erythrocyte blood group ABH and P 1 glycosphingolipid antigens. The accumulation of globoside in tissue, due to a defect in hexosaminidases A and B, is the cause of Sandhoff disease.Scalp: The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendinous galea aponeurotica; loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).Hair Follicle: A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.Hair: A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)Scalp DermatosesFolliculitis: Inflammation of follicles, primarily hair follicles.Dermoscopy: A noninvasive technique that enables direct microscopic examination of the surface and architecture of the SKIN.Tinea Capitis: Ringworm of the scalp and associated hair mainly caused by species of MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON, which may occasionally involve the eyebrows and eyelashes.Trichotillomania: Compulsion to pull out one's hair.Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.Photophobia: Abnormal sensitivity to light. This may occur as a manifestation of EYE DISEASES; MIGRAINE; SUBARACHNOID HEMORRHAGE; MENINGITIS; and other disorders. Photophobia may also occur in association with DEPRESSION and other MENTAL DISORDERS.Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.Eyebrows: Curved rows of HAIR located on the upper edges of the eye sockets.Triethylenephosphoramide: An insect chemosterilant and an antineoplastic agent.Hypotrichosis: Presence of less than the normal amount of hair. (Dorland, 27th ed)Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Ichthyosis: Any of several generalized skin disorders characterized by dryness, roughness, and scaliness, due to hypertrophy of the stratum corneum epidermis. Most are genetic, but some are acquired, developing in association with other systemic disease or genetic syndrome.Sebaceous Glands: Small, sacculated organs found within the DERMIS. Each gland has a single duct that emerges from a cluster of oval alveoli. Each alveolus consists of a transparent BASEMENT MEMBRANE enclosing epithelial cells. The ducts from most sebaceous glands open into a HAIR FOLLICLE, but some open on the general surface of the SKIN. Sebaceous glands secrete SEBUM.

*  Androgenetic Alopecia in Fabry Disease - Full Text View - ClinicalTrials.gov

Alopecia. Alopecia Areata. Hypotrichosis. Sphingolipidoses. Metabolism, Inborn Errors. Lipidoses. Lipid Metabolism, Inborn ... No and frontal only androgenetic alopecia [ Time Frame: 1 Year ]. No and frontal only androgenetic alopecia opposed to vertex ... Outcome Measures: The levels of the outcome will be no androgenic alopecia and frontal only androgenetic alopecia opposed to ... Vertex only and frontal and vertex androgenetic alopecia. [ Time Frame: 1 Year ]. No and frontal only androgenetic alopecia ...

*  Hair loss. What causes hair loss? Hair cycle. Anagen hair loss. Soalas Dermatolgoy & Laser Clinic. Page 1 - PDF

What is androgenetic alopecia? What is androgenetic alopecia? Androgenetic alopecia is also called male pattern alopecia. It ... The Mystery of Alopecia The Mystery of Alopecia Larry N. Swanson, Pharm.D. Linda Miller Butz, Pharm.D. Candidate Alopecia is a ... CICATRICIAL ALOPECIA What you should know about CICATRICIAL ALOPECIA CICATRICIAL ALOPECIA RESEARCH FOUNDATION www.carfintl.org ... Dermatology Alopecia patientinformation Rotherham Hospital Your health, your choice, our passion What is alopecia? Alopecia is ...

*  Antiandrogen - wikidoc

... androgenetic alopecia (male pattern baldness), and hirsutism (excessive hairiness). They are also occasionally used as a male ...

*  What Is Hair Loss (Alopecia)? - Hair Loss (Alopecia) - HealthCommunities.com

This page provides complete information about having hair loss alopecia. ... Hair loss of any sort is known as alopecia-is it normal male-pattern baldness that usually occurs as men age, or abnormal hair ... In nonscarring alopecia (which includes AGA and alopecia areata), the follicles are preserved, so that regrowth of lost hair ... Hair loss of any sort is called alopecia-be it normal male-pattern baldness (androgenic alopecia, or AGA) that commonly occurs ...

*  Androgenetic Alopecia

... is a common form of hair loss in both men and women. In men, hair is usually lost in a well-defined ... Androgenetic alopecia is the most common type of hair loss, affecting women (50% of menopausal women and a large number of ... Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most ... Androgenetic alopecia in women rarely leads to total baldness. A variety of genetic and environmental factors likely play a ...

*  Alopecia areata - Wikipedia

a b c d e f g h i Zoe Diana Draelos (August 30, 2007), Alopecia Areata Archived 2007-12-08 at the Wayback Machine.. MedicineNet ... Trichotillomania, alopecia mucinosa, postpartum alopecia[1]. Treatment. Sunscreen, head coverings to protect from sun and cold[ ... Alopecia areata and alopecia barbae have been identified by some as the biblical nethek condition that is part of the greater ... a b c d e f Alopecia Areata at Merck Manual of Diagnosis and Therapy Professional Edition ...

*  Alopecia mucinosa - Wikipedia

Alopecia mucinosa (also known as "Follicular mucinosis," "Mucinosis follicularis,",[1] "Pinkus' follicular mucinosis,"[1] and " ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Alopecia_mucinosa&oldid=782222140" ...

*  Alopecia: Kayla's Story

Finally, when I was almost 12, I was diagnosed with alopecia areata. Doctors believe alopecia areata is an autoimmune disease ... alopecia areata.'. Her classmates needed no explanation since it was obvious that the girl had lost her eyelashes, eyebrows, ...

*  Patterned alopecia definition | Drugs.com

Definition of patterned alopecia. Provided by Stedman's medical dictionary and Drugs.com. Includes medical terms and ...

*  ALOPECIA AREATA AND STRABISMUS | The BMJ

ALOPECIA AREATA AND STRABISMUS. Br Med J 1922; 2 doi: https://doi.org/10.1136/bmj.2.3229.1001-d (Published 18 November 1922) ...

*  Alopecia areata: Symptoms, treatment, and tips

Alopecia areata is a type of hair loss that affects patches of the scalp. It is usually temporary. Find out what causes it, how ... Alopecia refers to any type of hair loss. In a person with alopecia areata, smooth, round patches of hair loss appear over a ... Alopecia Areata: Causes, Symptoms, and Treatment Alopecia areata is a common autoimmune disorder that can affect anyone, ... What is alopecia areata?. Alopecia areata causes hairless patches on the scalp. ...

*  Thrush/Alopecia - Autoimmune Disorders - MedHelp

I recently have had my first Alopecia Areata bout. It was discovered in May of 2009 with a single spot at the back of my head ( ... Thrush/Alopecia. I recently have had my first Alopecia Areata bout. It was discovered in May of 2009 with a single spot at the ... I recently have had my first Alopecia Areata bout. It was discovered in May of 2009 with a single spot at the back of my head ( ... Corresponding with my discovery of my alopecia in May 09 I was also diagnosed and treated for thrush (genital region). At the ...

*  Hair - Hair Loss (Alopecia) - MedHelp

Androgenic alopecia is a common form of hair loss and typically occurs in M shaped pattern. Men who have this type of hair loss ... Androgenic alopecia is a common form of hair loss and typically occurs in M shaped pattern. Men who have this type of hair loss ...

*  Alopecia - Medical Dictionary / Glossary | Medindia

Alopecia' - Hair loss, is clearly explained in Medindia s glossary of medical terms ... Alopecia - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review Team on May ...

*  Psychogenic Alopecia in Cats - PetPlace

... psychogenic alopecia. One of the results of compulsive hair pulling in humans and cats is alopecia (baldness). The problem can ... Psychogenic Alopecia in Cats. 23 July 23, 2015 Dr. Nicholas Dodman 95,028 Views ... With psychogenic alopecia it is common to find broken, barbered hair shafts rather than intact hairs with the root attached. ... Not all cats with psychogenic alopecia respond to SSRIs. For those that don't, the anxiety-reducing drug buspirone (Buspar) may ...

*  POINTS FROM LETTERS: Traction Alopecia | The BMJ

POINTS FROM LETTERS: Traction Alopecia. Br Med J 1960; 2 doi: https://doi.org/10.1136/bmj.2.5201.806-f (Published 10 September ...

*  A Depression-Hyposexual-Alopecia Syndrome | The BMJ

A Depression-Hyposexual-Alopecia Syndrome. Br Med J 1942; 2 doi: https://doi.org/10.1136/bmj.2.4254.67 (Published 18 July 1942) ...

*  Ethical Hair? - Hair Loss (Alopecia) - MedHelp

Hi there...I also suffer from thinning hair. I have tried going down the 'Propecia' route, but this was an experience I would never repeat. Instead I have decided to go for a hair system. I am at a l...

*  Lipedematous alopecia | Define Lipedematous alopecia at Dictionary.com

Lipedematous alopecia definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... lipedematous alopecia in Medicine Expand. lipedematous alopecia lip·e·dem·a·tous alopecia (lĭp'ĭ-děm'ə-təs). n. Hair loss ...

*  Cicatricial Scarring Alopecia Causes, Symptoms, & Treatments

Read on for information on the causes, symptoms and treatment of cicatricial scarring alopecia. ... Scarring alopecia is also known as cicatricial scarring alopecia. ... Scarring alopecia, also known as cicatricial scarring alopecia, refers to a category of hair loss disorders. There are many ... While in some forms of scarring alopecia the hair loss is rapid and accompanied by severe irritation and pain in the scalp, in ...

*  Essential Oils for Alopecia | LIVESTRONG.COM

... alopecia is the loss of hair, and this condition can occur for many different reasons, including... ... Essential Oils for Alopecia by KRISTIE JERNIGAN Last Updated: Aug 14, 2017. ... According to the University of Maryland Medical Center, alopecia is the loss of hair, and this condition can occur for many ... The loss of hair can cause anxiety and depression to any alopecia sufferer. The University of Maryland Medical Center reports ...

*  Spironolactone or Finasteride? - Hair Loss (Alopecia) - MedHelp

This question is not really about hair loss even thought the Doc who is a Endocrinologist is prescribing Finasteride. I'm 26 and a type1 diabetic, I have been taking Spironolactone for its anti-androg...

*  Alopecia Archives - AboutLawsuits.com

Tag Archives: Alopecia Taxotere Hair Loss Cases Set for Bellwether Trials in September 2018, and Throughout 2019 * October 24, ... Taxotere Alopecia Side Effects Result in Lawsuit Over Permanent Hair Loss After Chemotherapy * March 13, 2017 ... Taxotere Class Action Certification Sought Over Permanent Alopecia Risks * April 28, 2017 ... a California woman has filed a lawsuit alleging Sanofi-Aventis failed to warn about the risk of permanent alopecia, providing ...

*  e-Tutor - Dictionary - 'alopecia'

Definition of 'alopecia'. You searched for alopecias. Noun. *loss of hair (especially on the head) or loss of wool or feathers ...

*  Alopecia - androgenetic - ONA

Occasionally scarring alopecias, specifically central centrifugal cicatricial alopecia, can present similarly to male pattern ... Scalp Cooling Reduces Risk of Chemotherapy-Induced Alopecia. *Technique for Minimizing Chemotherapy-Induced Alopecia Gaining a ... Two variants of lichen planopilaris, namely frontal fibrosing alopecia (FFA) and fibrosing alopecia in a patterned distribution ... "Androgenetic alopecia and cardiovascular risk factors in men and women: A comparative study". J Am Acad Dermatol. vol. 63. 2010 ...

Central centrifugal cicatricial alopecia: Central centrifugal cicatricial alopecia (CCCA), also referred to as hot comb alopecia and follicular degeneration syndrome, is a type of alopecia first noticed in African Americans in the 1950s and reported by LoPresti et al. in 1968 as a result of application of petrolatum followed by a stove-heated iron comb.
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Lactotriaosylceramide beta-1,4-galactosyltransferase: Lactotriaosylceramide beta-1,4-galactosyltransferase (, beta4Gal-T4, UDP-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase) is an enzyme with system name UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase. This enzyme catalyses the following chemical reactionScalp reconstruction: Scalp reconstruction is a surgical procedure for people with scalp defects. Scalp defects may be partial or full thickness and can be congenital or acquired.Hair follicle nevus: Hair follicle nevus (also known as a "Vellus hamartoma") is a cutaneous condition that presents as a small papule from which fine hairs protrude evenly from the surface.Hair analysisMinoxidilBeare–Stevenson cutis gyrata syndrome: Beare–Stevenson cutis gyrata syndrome is a rare genetic disorder characterized by craniosynostosis (premature fusion of certain bones of the skull, sometimes resulting in a characteristic 'cloverleaf skull'; further growth of the skull is prevented, and therefore the shape of the head and face is abnormal) and a specific skin abnormality, called cutis gyrata, characterized by a furrowed and wrinkled appearance (particularly in the face and on the palms and soles of the feet); thick, dark, velvety areas of skin (acanthosis nigricans) are sometimes found on the hands and feet and in the groin.http://ghr.Eosinophilic pustular folliculitis of infancy: Eosinophilic pustular folliculitis of infancy (also known as "Eosinophilic pustular folliculitis in infancy," "Infantile eosinophilic pustular folliculitis," and "Neonatal eosinophilic pustular folliculitis") is a cutaneous condition characterized by recurrent pruritic crops of follicular vesiculopustular lesions.Antonella Tosti: Antonella Tosti is an Italian physician and scientist with major contributions in the field of dermatology.Tinea capitis: (ILDS B35.006) |TrichotillomaniaIchthyosis follicularis with alopecia and photophobia syndromeGraham-Little syndrome: Graham-Little syndrome is a cutaneous condition characterized by lichen planus-like skin lesions.Freedberg, et al.Eyebrow: The eyebrow is an area of thick, delicate hairs above the eye that follows the shape of the lower margin of the brow ridges of some mammals. Their main function is hypothesized to prevent sweat, water, and other debris from falling down into the eye socket, but they are also important to human communication and facial expression.Marie Unna hereditary hypotrichosis: Marie Unna hereditary hypotrichosis (also known as "Marie Unna hypotrichosis") is an autosomal dominant condition characterized by scalp hair that is sparse or absent at birth, with variable coarse, wiry hair regrowth in childhood, and potential loss again at puberty.Freedberg, et al.Dermal equivalent: The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel.Ichthyosis

(1/646) Phase II trial of paclitaxel and cisplatin in metastatic and recurrent carcinoma of the uterine cervix.

PURPOSE: Both paclitaxel and cisplatin have moderate activity in patients with metastatic or recurrent cancer of the cervix, and the combination of these two agents has shown activity and possible synergism in a variety of solid tumors. We administered this combination to patients with metastatic or recurrent cervical cancer to evaluate its activity. PATIENTS AND METHODS: Thirty-four consecutive patients were treated on an outpatient basis with paclitaxel 175 mg/m2 administered intravenously over a 3-hour period followed by cisplatin 75 mg/m2 administered intravenously with granulocyte colony-stimulating factor support. The chemotherapy was administered every 3 weeks for a maximum of six courses. RESULTS: Sixteen patients (47%; 95% confidence interval, 30% to 65%) achieved an objective response, including five complete responses and 11 partial responses. Responses occurred in 28% of patients with disease within the radiation field only and in 57% of patients with disease involving other sites. The median duration of response was 5.5 months, and the median times to progression and survival for all patients were 5 and 9 months, respectively. Grade 3 or 4 toxicities included anemia in 18% of patients and granulocytopenia in 15% of patients. Fifty-three percent of patients developed some degree of neurotoxicity; 21% of cases were grade 2 or worse. CONCLUSION: The combination of paclitaxel with cisplatin seems relatively well tolerated and moderately active in patients with metastatic or recurrent cervical cancer. The significant incidence of neurotoxicity is of concern, and alternative methods of administration of the two agents could be evaluated. Then, further study of this combination, alone or with the addition of other active agents, is warranted.  (+info)

(2/646) Phase I-II study of gemcitabine and carboplatin in stage IIIB-IV non-small-cell lung cancer.

PURPOSE: Platinum-based chemotherapy currently represents standard treatment for advanced non-small-cell lung cancer. Gemcitabine is one of the most interesting agents currently in use in advanced non-small-cell lung cancer, and high response rates have been reported when it is administered in combination with cisplatin. The aim of the present study was to evaluate the combination of gemcitabine and carboplatin in a phase I-II study. PATIENTS AND METHODS: Chemotherapy-naive patients with stage IIIB-IV non-small-cell lung cancer received carboplatin at area under the concentration-time curve (AUC) 5 mg/mL/min and gemcitabine at an initial dose of 800 mg/m2, subsequently escalated by 100 mg/m2 per step. Gemcitabine was administered on days 1 and 8 and carboplatin on day 8 of the 28-day cycle. Dose escalation proceeded up to dose-limiting toxicity (DLT), which was defined as grade 4 neutropenia or thrombocytopenia or grade 3 nonhematologic toxicity. RESULTS: Neutropenia was DLT, inasmuch as it occurred in three of five patients receiving gemcitabine 1,200 mg/m2. Nonhematologic toxicities were mild. Gemcitabine 1,100 mg/m2 plus carboplatin AUC 5 was recommended for phase II studies. An objective response was observed in 13 (50%) of 26 patients, including four complete responses (15%) and nine partial responses (35%). Median duration of response was 13 months (range, 3 to 23 months). Median overall survival was 16 months (range, 3 to 26 months). CONCLUSION: The combination of gemcitabine and carboplatin is well tolerated and active. Neutropenia was DLT. The observed activity matches that observable in cisplatin-gemcitabine studies, whereas duration of response and survival are even higher. A phase II trial is under way.  (+info)

(3/646) Longevity, stress response, and cancer in aging telomerase-deficient mice.

Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR-/- mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However, age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing and hematopoietic ablation. In addition, we found an increased incidence of spontaneous malignancies. These findings demonstrate a critical role for telomere length in the overall fitness, reserve, and well being of the aging organism.  (+info)

(4/646) Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group.

Leukemic patients receiving marrow from HLA-identical sibling donors were randomized to treatment with either busulfan 16 mg/kg (n = 88) or total body irradiation ([TBI] n = 79) in addition to cyclophosphamide 120 mg/kg. The patients were observed for a period of 5 to 9 years. Busulfan-treated patients had an increased risk of veno-occlusive disease (VOD) of the liver (12% v 1%, P =.01) and hemorrhagic cystitis (32% v 10%, P =.003). Acute graft-versus-host disease (GVHD) was similar in the two groups, but the 7-year cumulative incidence of chronic GVHD was 59% in the busulfan-treated group versus 47% in the TBI group (P =.05). Death from GVHD was more common in the busulfan group (22% v 3%, P <.001). Obstructive bronchiolitis occurred in 26% of the busulfan patients but in only 5% of the TBI patients (P <.01). Complete alopecia developed in 8 busulfan patients and partial alopecia in 17, versus five with partial alopecia in the TBI group (P <.001). Cataracts occurred in 5 busulfan-treated patients and 16 TBI patients (P =.02). The incidence of relapse after 7 years was 29% in both groups. Seven-year transplant-related mortality (TRM) in patients with early disease was 21% in the busulfan group and 12% in the TBI group. In patients with more advanced disease, the corresponding figures were 64% and 22%, respectively (P =.004). Leukemia-free survival (LFS) in patients with early disease was 68% in busulfan-treated patients and 66% in TBI patients. However, 7-year LFS in patients with more advanced disease was 17% in the busulfan group versus 49% in the TBI group (P <.01). In patients with chronic myeloid leukemia (CML) in first chronic phase, 7-year LFS was 72% and 83% in the two groups, respectively.  (+info)

(5/646) Clomipramine-induced urinary retention in a cat.

A 10-year-old, female, spayed shorthair with presumed psychogenic alopecia was treated with clomipramine (1 mg/kg body weight/day). The cat developed urinary retention within 2 days. Clomipramine was discontinued. Clinical signs resolved over the next 7 days. The urinary retention was attributed to the anticholinergic effects of clomipramine.  (+info)

(6/646) Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias.

Recently, we showed that atrichia with papular lesions (APL), a rare inherited form of alopecia, is transmitted as an autosomal recessive trait in a large inbred kindred of Israeli-Arab origin. Furthermore, we mapped the APL locus to a 5-cM region of chromosome 8p12 in this family. The human "hairless" gene is a candidate target gene for the disease mutation because it maps to the APL locus and because it was recently found to be mutated in a related but clinically distinct form of alopecia known as "alopecia universalis" or "congenital alopecia." In the present study, the coding sequence of the hairless gene was compared by reverse transcription-PCR in fibroblast cell lines derived from an affected patient and an unrelated individual. We identified a single-base deletion (3434delC) in the hairless gene that cosegregated with the disease phenotype in the family. This deletion is predicted to cause a frameshift mutation in the highly conserved C-terminal part of the hairless protein, a region putatively involved in the transcription factor activity of the hairless gene product. The present results are indicative of phenotypic heterogeneity in inherited atrichias caused by mutations in the hairless gene, suggesting different roles for the regions mutated in APL and in other forms of congenital atrichia during hair development.  (+info)

(7/646) Medical treatments for balding in men.

Two drugs are available for the treatment of balding in men. Minoxidil, a topical product, is available without a prescription in two strengths. Finasteride is a prescription drug taken orally once daily. Both agents are modestly effective in maintaining (and sometimes regrowing) hair that is lost as a result of androgenic alopecia. The vertex of the scalp is the area that is most likely to respond to treatment, with little or no hair regrowth occurring on the anterior scalp or at the hairline. Side effects of these medications are minimal, making them suitable treatments for this benign but psychologically disruptive condition.  (+info)

(8/646) Insulin gene polymorphism and premature male pattern baldness in the general population.

Insulin is found in hair follicles and may play a role in the regulation of androgen metabolism and the hair growth cycle, which are relevant to the loss of scalp hair known as male pattern baldness. An excess of dihydrotestosterone on balding scalp indicates that the condition is androgen dependent. Premature male pattern baldness may be the male phenotype of familial polycystic ovary syndrome, a condition characterized by high levels of androgens and insulin that has been linked to insulin gene polymorphism. Therefore, we studied possible associations between relevant insulin gene polymorphisms and premature male pattern baldness in the general community. We examined the distribution of three dimorphic restriction fragment length polymorphisms: HphI, PstI and FokI in cases consisting of 56 men aged 18-30 years with significant baldness, and in 107 control men aged 50 years or more with no indication of baldness. No significant differences between cases and controls in allele, genotype or haplotype frequencies were identified. We conclude that, in the general population, the insulin gene is not associated with premature male pattern baldness.  (+info)




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scalp

  • Alopecia areata most often affects the scalp and beard, but may occur on any part of the body with hair. (wikipedia.org)
  • Alopecia areata is a type of hair loss that affects patches of the scalp, and sometimes other parts of the body. (medicalnewstoday.com)
  • Alopecia areata causes hairless patches on the scalp. (medicalnewstoday.com)
  • While in some forms of scarring alopecia the hair loss is rapid and accompanied by severe irritation and pain in the scalp, in most types, the hair loss is slow and gradual, without any obvious symptoms and may not even be noticeable for a long time. (home-remedies-for-you.com)
  • Scarring alopecia symptoms may include, redness of the base of the hair shaft, itchiness, scaling, and skin (scalp) pigmentation. (home-remedies-for-you.com)
  • The University of Maryland Medical Center reports that essential oils can be effectively used to treat alopecia through therapeutic massage, which can help to improve circulation in the scalp. (livestrong.com)
  • Rubbing a small amount of the essential oil on the scalp and leaving it on overnight may be enough to stimulate hair growth in a person suffering from alopecia. (livestrong.com)
  • Central centrifugal cicatricial alopecia can involve only the crown of the scalp. (oncologynurseadvisor.com)
  • Scalp cooling has specifically been used to prevent alopecia in docetaxel chemotherapy, although it has been found prophylactic in other regimens as well. (wikipedia.org)
  • citation needed] Commonly, alopecia areata involves hair loss in one or more round spots on the scalp. (wikipedia.org)
  • Tumor alopecia is the hair loss in the immediate vicinity of either benign or malignant tumors of the scalp. (wikipedia.org)
  • Traumatic alopecia is a cutaneous condition that results from the forceful pulling out of the scalp hair. (wikipedia.org)
  • Alopecia neoplastica may present as a scarring alopecia, appearing anywhere on the scalp, and it has been described with cutaneous metastasis from breast, gastric, lung, renal and pancreatic carcinomas. (wikipedia.org)
  • Pressure alopecia (also known as "Postoperative alopecia," and "Pressure-induced alopecia") occurs in adults after prolonged pressure on the scalp during general anesthesia, with the head fixed in one position, and may also occur in chronically ill persons after prolonged bed rest in one position that causes persistent pressure on one part of the scalp, all likely due to pressure-induced ischemia. (wikipedia.org)
  • Lipedematous alopecia (also known as "Lipedematous scalp") is a disorder characterized by a thick boggy scalp and hair loss. (wikipedia.org)
  • Compressive safety helmets worn tightly and closely to the scalp are a cause of traction alopecia. (wikipedia.org)
  • This is a clinical finding that describes the diagnosis of some primary cicatricial alopecias as noted mainly in the central scalp, and includes CCCA, folliculitis decalvans, and any other potential centrally presenting cicatricial alopecia. (wikipedia.org)

associated with alopecia areata

  • In 2010, a genome-wide association study was completed that identified 129 single nucleotide polymorphisms that were associated with alopecia areata. (wikipedia.org)

cutaneous

  • Traction alopecia List of cutaneous conditions Rapini, Ronald P. (wikipedia.org)
  • Alopecia areata List of cutaneous conditions Rapini, Ronald P. (wikipedia.org)
  • Hot comb alopecia List of cutaneous conditions Rapini, Ronald P. (wikipedia.org)
  • Cicatricial alopecia List of cutaneous conditions Hot comb Woolery-lloyd, Heather. (wikipedia.org)

areata is not

frontal fibrosin

  • Two variants of lichen planopilaris, namely frontal fibrosing alopecia (FFA) and fibrosing alopecia in a patterned distribution (FAPD), can be confused with female pattern hair loss. (oncologynurseadvisor.com)
  • Even though this "fringe sign" is considered a useful clinical marker of this condition, cases of frontal fibrosing alopecia presenting with an unusual retention of the hairline (pseudo-fringe sign) have been described. (wikipedia.org)
  • Frontal Fibrosing Alopecia is the frontotemporal hairline recession and eyebrow loss in postmenopausal women that is associated with perifollicular erythema, especially along the hairline. (wikipedia.org)
  • Frontal Fibrosing Alopecia has been most often reported in post-menopausal women with higher levels of affluence and a negative smoking history. (wikipedia.org)
  • Although the pathogenesis of Frontal Fibrosing Alopecia is poorly understood, autoimmune reaction and hormonal factors may play a role. (wikipedia.org)
  • In one study, the use of anti-androgens (finasteride or dutasteride) was associated with improvement in 47% and stabilization in 53% of patients Recently, successful treatment of facial papules in patients with frontal fibrosing alopecia was described with oral isotretinoin. (wikipedia.org)
  • Macdonald A, Clark C, Holmes S. Frontal fibrosing alopecia: a review of 60 cases. (wikipedia.org)
  • Banka N, Mubki T, Bunagan MJ, Mcelwee K, Shapiro J. Frontal fibrosing alopecia: a retrospective clinical review of 62 patients with treatment outcome and long-term follow-up. (wikipedia.org)
  • Pirmez R, Donati A, Valente NS, Sodré CT, Tosti A. Glabellar red dots in frontal fibrosing alopecia: a further clinical sign of vellus follicle involvement. (wikipedia.org)
  • Depression of the frontal veins: A new clinical sign of frontal fibrosing alopecia. (wikipedia.org)
  • Pirmez R, Duque-Estrada B, Donati A, Campos-do-Carmo G, Valente NS, Romiti R, Sodré CT, Tosti A. Clinical and dermoscopic features of lichen planus pigmentosus in 37 patients with frontal fibrosing alopecia. (wikipedia.org)
  • Kossard S. Postmenopausal frontal fibrosing alopecia: scarring alopecia in a pattern distribution. (wikipedia.org)
  • Frontal fibrosing alopecia: a multicenter review of 355 patients. (wikipedia.org)
  • Pirmez R, Duque-Estrada B, Barreto T, Quintella DC, Cuzzi T. Successful Treatment of Facial Papules in Frontal Fibrosing Alopecia with Oral Isotretinoin. (wikipedia.org)

follicular degeneration syndrome

  • The cause of each kind of scarring alopecia cannot really be diagnosed very well, but the disorder may evolve from conditions like hot comb alopecia (follicular degeneration syndrome), dissecting cellulitis, lichen planopilaris and others. (home-remedies-for-you.com)
  • Central centrifugal cicatricial alopecia (CCCA), also referred to as hot comb alopecia and follicular degeneration syndrome, is a type of alopecia first noticed in African Americans in the 1950s and reported by LoPresti et al. (wikipedia.org)
  • It has also been referred to as: Hot comb alopecia Follicular degeneration syndrome Pseudopelade in African Americans Central elliptical pseudopelade in Caucasians Also in this category is cicatricial pattern hair loss (CPHL). (wikipedia.org)

Totalis

  • Alopecia totalis is the loss of all skull and facial hair. (wikipedia.org)

comb alopecia

  • Hot comb alopecia was first reported in the late 1960s as a scarring alopecia seen in black women who straightened their hair with hot combs for cosmetic purposes, developing characteristically on the crown and spreading peripherally to form a large oval area of partial hair loss. (wikipedia.org)

central centrifugal

  • Occasionally scarring alopecias, specifically central centrifugal cicatricial alopecia, can present similarly to male pattern hair loss. (oncologynurseadvisor.com)
  • Recent clarifications have been made, with the term "central centrifugal cicatritial alopecia" adopted as a diagnostic category by the North American Hair Research Society. (wikipedia.org)
  • A similarly sounding term is central centrifugal scarring alopecia (CCSA). (wikipedia.org)
  • L.C. Sperling, Central, centrifugal scarring alopecia. (wikipedia.org)

Scarring Alopecia

  • Scarring alopecia, also known as cicatricial scarring alopecia, refers to a category of hair loss disorders. (home-remedies-for-you.com)
  • There are many types of scarring alopecia, but normally in most scarring alopecia cases, the hair follicles are permanently destroyed and replaced with scar tissues. (home-remedies-for-you.com)
  • At times, chronic lupus erythematosus, an autoimmune disease which affects different parts of the body, may also involve scarring alopecia. (home-remedies-for-you.com)
  • Nevertheless, most forms of scarring alopecia causes inflammation of the hair follicle, thereby destroying stem cells and sebaceous glands, leading to permanent hair loss. (home-remedies-for-you.com)
  • Treating cicatricial scarring alopecia may be very difficult because once the hair follicle is destroyed, restoration becomes difficult. (home-remedies-for-you.com)
  • Because, as such there are no real FDA approved scarring alopecia treatments, all treatment depends upon the physician or dermatologist. (home-remedies-for-you.com)
  • Generally corticosteroids (in the form of injections or topical applications) are used to treat inflammation of hair follicles caused during scarring alopecia. (home-remedies-for-you.com)
  • Another method to treat scarring alopecia involves surgery. (home-remedies-for-you.com)
  • However, in scarring alopecia, the follicular orifices are obliterated and the skin has the feeling of "slick cement. (oncologynurseadvisor.com)
  • It is a scarring alopecia that has been associated with a loss of eyebrows, facial papules, glabellar red dots, and prominent venous vasculature in the forehead. (wikipedia.org)
  • Central Centrigugal Scarring Alopecia. (wikipedia.org)

psychogenic alopecia

  • The new definition helps us better understand and determine the cause, course, and therapy of the feline equivalent, psychogenic alopecia. (petplace.com)
  • Medical conditions that can be confused with psychogenic alopecia and must be ruled out before the diagnosis can be confirmed. (petplace.com)
  • For those familiar with psychogenic alopecia, the appearance is fairly typical, and parasites are fairly easy to detect, but confusion is possible in some cases unless a careful inspection is made. (petplace.com)
  • With psychogenic alopecia it is common to find broken, barbered hair shafts rather than intact hairs with the root attached. (petplace.com)
  • Psychogenic alopecia, also called over-grooming or psychological baldness, is a compulsive behavior that affects domestic cats. (wikipedia.org)
  • Generally, psychogenic alopecia does not lead to serious health consequences or a decreased lifespan. (wikipedia.org)

androgenetic alopecia

  • The authors prefer the term male/female pattern hair loss, in place of androgenetic alopecia, because serum androgen levels are normal in the majority of patients and 50% of the time there is no family history. (oncologynurseadvisor.com)
  • This CCCA pattern is a potential alopecia mimic that can be confused for androgenetic alopecia. (wikipedia.org)

lichen planopilaris

  • Kossard S, Lee MS, Wilkinson B. Postmenopausal alopecia: a frontal variant of lichen planopilaris. (wikipedia.org)

centrifugal alopecia

  • A condition known as CCCA (central cicatricial centrifugal alopecia), seen almost exclusively in African American women, can cause extensive hair loss. (wikipedia.org)

type of alopecia

  • People with this type of alopecia have hairs that become narrower along the length of the strand closer to the base. (medicalnewstoday.com)

hair loss

  • Alopecia refers to any type of hair loss. (medicalnewstoday.com)
  • In a person with alopecia areata, smooth, round patches of hair loss appear over a few weeks. (medicalnewstoday.com)
  • Androgenic alopecia is a common form of hair loss and typically occurs in M shaped pattern. (medhelp.org)
  • Triangular alopecia (also known as "Temporal alopecia" and "Temporal triangular alopecia") (TTA) is hair loss that may be congenital but usually appears in childhood as a focal patch of loss that may be complete or leaving fine vellus hairs behind. (wikipedia.org)
  • It is a non-inflammatory, non-scarring form of hair loss easily confused with alopecia areata. (wikipedia.org)
  • Traction alopecia is a form of alopecia, or gradual hair loss, caused primarily by pulling force being applied to the hair. (wikipedia.org)
  • Traction alopecia is a substantial risk in hair weaves, which can be worn either to conceal hair loss, or purely for cosmetic purposes. (wikipedia.org)
  • Traction Alopecia is one of the most common causes of hair loss in African American women. (wikipedia.org)
  • Men and women who have suffered from traction alopecia have found that the hair loss occurs most at the hair line-primarily around the temples and the sides of their heads. (wikipedia.org)
  • Important diagnoses to consider include female pattern hair loss (FPHL), chronic telogen effluvium (CTE), and alopecia areata (AA). (wikipedia.org)
  • Female Pattern Hair Loss and its Relationship to Permanent/Cicatricial Alopecia: A New Perspective. (wikipedia.org)

Traction

  • Traction alopecia is recession of the hairline due to chronic traction, or hair pulling, and is characterized by a fringe along the marginal hairline on physical exam. (wikipedia.org)
  • Traction alopecia is mechanical in cause, rather than androgenic, and treatment is typically not pharmaceutical. (wikipedia.org)
  • Sikh men are also susceptible to traction alopecia if the hair under the turban is tied too tightly for many years. (wikipedia.org)
  • Frequent wearers or those who use such helmets for prolonged periods seem more likely to suffer traction alopecia. (wikipedia.org)
  • Some have hypothesized that CCCA represents an end stage of traction alopecia. (wikipedia.org)

Androgenic

  • Androgenic pattern presentation of scarring and inflammatory alopecia. (wikipedia.org)

universalis

  • Alopecia areata Alopecia universalis Joly, Pascal (2006). (wikipedia.org)
  • Alopecia universalis (AU) or alopecia areata universalis is a medical condition involving loss of all hair, including eyebrows and eyelashes. (wikipedia.org)
  • Alopecia universalis can occur at any age, and is currently believed to be an autoimmune disorder, in which a person's immune system attacks the hair follicles. (wikipedia.org)
  • There is no standard treatment for alopecia universalis. (wikipedia.org)

baldness

  • Alopecia areata , also known as spot baldness , is a condition in which hair is lost from some or all areas of the body. (wikipedia.org)
  • One of the results of compulsive hair pulling in humans and cats is alopecia (baldness). (petplace.com)

pathogenesis

  • Endogenous retinoids metabolic defect is a key part of the pathogenesis of the alopecia areata. (wikipedia.org)

clinical

  • Alopecia areata is usually diagnosed based on clinical features. (wikipedia.org)
  • Alopecia mimics have proven a problem in establishing diagnosis of alopecia when using only clinical evaluation. (wikipedia.org)

symptoms

  • Typical first symptoms of alopecia areata are small bald patches. (wikipedia.org)

autoimmune disease

  • Alopecia areata is believed to be an autoimmune disease . (wikipedia.org)
  • Doctors believe alopecia areata is an autoimmune disease in which the hair follicles are damaged by a person's own immune system. (kidshealth.org)

congenital

  • A few cases of babies being born with congenital alopecia areata have been reported. (wikipedia.org)

inflammatory

  • Occasionally, in inactive alopecia areata, no inflammatory infiltrates are found. (wikipedia.org)

chemotherapy

  • After undergoing breast cancer chemotherapy with the drug Taxotere, a California woman has filed a lawsuit alleging Sanofi-Aventis failed to warn about the risk of permanent alopecia, providing false and misleading information that suggested hair would regrow following treatment. (aboutlawsuits.com)

hairs

  • In alopecia areata, trichoscopy shows regularly distributed "yellow dots" (hyperkeratotic plugs), small exclamation-mark hairs, and "black dots" (destroyed hairs in the hair follicle opening). (wikipedia.org)

diagnosis

  • A biopsy is rarely needed to make the diagnosis or aid in the management of alopecia areata. (wikipedia.org)

susceptible

  • It was only recently after ongoing episodic thrush outbreaks and further study have I read that due to my immune disorder (alopecia) that I am more susceptible to thrush outbreaks. (medhelp.org)

humans

  • Alopecia is a disease which can affect other animals besides humans. (wikipedia.org)

treatment

  • With early treatment, alopecia areata can be reversible. (medicalnewstoday.com)
  • In addition, rosemary is considered an excellent antifungal treatment for fungal infections that might be causing the alopecia. (livestrong.com)
  • According to the National Center for Complementary and Alternative Medicine, lavender essential oil can be combined with other oils such as thyme and cedarwood to help with the treatment of alopecia. (livestrong.com)
  • National Alopecia Areata Foundation based in San Rafael, California is dedicated to the discovery of a cure or treatment for alopecia areata and supporting the conditions victims. (wikipedia.org)

cats

  • Dermatophytosis as a cause of alopecia is common in cats, too, and in long-haired varieties, dermatophytic pseudomycetomas may be to blame. (wikipedia.org)

depression

  • The loss of hair can cause anxiety and depression to any alopecia sufferer. (livestrong.com)

loss

  • According to the University of Maryland Medical Center, alopecia is the loss of hair, and this condition can occur for many different reasons, including damaged hair follicles and fungal infections. (livestrong.com)

typically

  • Ferret adrenal disease is extremely common and is the most common cause of alopecia in ferrets, typically affecting middle-aged specimens between three and seven years old. (wikipedia.org)

cause

  • Alopecia can cause emotional distress, but using a wig or shaving the head can ease these difficulties. (medicalnewstoday.com)
  • In rabbits, dermatophytosis is a prime cause of alopecia in young, newly weaned specimens. (wikipedia.org)

cases

  • In cases of alopecia areata, hair will tend to pull out more easily along the edge of the patch where the follicles are already being attacked by the body's immune system than away from the patch where they are still healthy. (wikipedia.org)

form

common

  • Canine pinnal alopecia is most common in dachshunds, but others, such as Chihuahuas, Boston terriers, whippets and Italian greyhounds, may also be vulnerable. (wikipedia.org)