Spondylitis, Ankylosing
HLA-B27 Antigen
Spondylarthropathies
Arthritis
Iritis
Severity of Illness Index
Tuberculosis, Spinal
Arthritis, Reactive
Arthritis, Psoriatic
Rheumatic Diseases
Balneology
Uveitis, Anterior
Lumbar Vertebrae
Kyphosis
Arthritis, Rheumatoid
Thoracic Vertebrae
HLA Antigens
Cervical Vertebrae
Immunoglobulin G
Sulfasalazine
Anti-Inflammatory Agents, Non-Steroidal
Back Pain
Pseudarthrosis
Receptors, Tumor Necrosis Factor
Spinal Diseases
Treatment Outcome
Sacroiliitis
Klebsiella
Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report. (1/182)
OBJECTIVE: The NF-kappa B/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level. The aim of this study was to determine whether distinctive patterns of NF-kappa B activation are seen in different forms of joint disease. METHODS: The DNA binding activity of these nucleoproteins was examined in purified synovial and peripheral T cells from patients with various chronic rheumatic diseases (12: four with rheumatoid arthritis; five with spondyloarthropathies; and three with osteoarthritis). RESULTS: Electrophoretic mobility shift assays disclosed two specific complexes bound to a NF-kappa B specific 32P-labelled oligonucleotide in nucleoproteins extracted from purified T cells isolated from synovial fluid and peripheral blood of patients with rheumatoid arthritis. The complexes consisted of p50/p50 homodimers and p50/p65 heterodimers. Increased NF-kappa B binding to DNA in synovial T cells was observed relative to peripheral T cells. In non-rheumatoid arthritis, binding of NF-kappa B in synovial T cells was exclusively mediated by p50/p50 homodimers. CONCLUSION: Overall, the results suggest that NF-kappa B may play a central part in the activation of infiltrating T cells in chronic rheumatoid arthritis. The activation of this nuclear factor is qualitatively different in rheumatoid synovial T cells to that in other forms of non-rheumatoid arthritis (for example, osteoarthritis, spondyloarthropathies). (+info)Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases. (2/182)
The MR imaging findings of fungal spinal osteomyelitis in three recipients of organ transplants showed hypointensity of the vertebral bodies on T1-weighted sequences in all cases. Signal changes and enhancement extended into the posterior elements in two cases. Multiple-level disease was present in two cases (with a total of five intervertebral disks involved in three cases). All cases lacked hyperintensity within the disks on T2-weighted images. In addition, the intranuclear cleft was preserved in four of five affected disks at initial MR imaging. MR features in Candida and Aspergillus spondylitis that are distinct from pyogenic osteomyelitis include absence of disk hyperintensity and preservation of the intranuclear cleft on T2-weighted images. Prompt recognition of these findings may avoid delay in establishing a diagnosis and instituting treatment of opportunistic osteomyelitis in the immunocompromised patient. (+info)Rheumatic disease and the Australian aborigine. (3/182)
OBJECTIVE: To document the frequency and disease phenotype of various rheumatic diseases in the Australian Aborigine. METHODS: A comprehensive review was performed of the archaeological, ethnohistorical, and contemporary literature relating to rheumatic diseases in these indigenous people. RESULTS: No evidence was found to suggest that rheumatoid arthritis (RA), ankylosing spondylitis (AS), or gout occurred in Aborigines before or during the early stages of white settlement of Australia. Part of the explanation for the absence of these disorders in this indigenous group may relate to the scarcity of predisposing genetic elements, for example, shared rheumatoid epitope for RA, B27 antigen for AS. In contrast, osteoarthritis appeared to be common particularly involving the temporomandibular joint, right elbow and knees and, most probably, was related to excessive joint loading in their hunter gatherer lifestyle. Since white settlement, high frequency rates for rheumatic fever, systemic lupus erythematosus, and pyogenic arthritis have been observed and there are now scanty reports of the emergence of RA and gout in these original Australians. CONCLUSION: The occurrence and phenotype of various rheumatic disorders in Australian Aborigines is distinctive but with recent changes in diet, lifestyle, and continuing genetic admixture may be undergoing change. An examination of rheumatic diseases in Australian Aborigines and its changing phenotype may lead to a greater understanding of the aetiopathogenesis of these disorders. (+info)Studying patients with inflammatory back pain and arthritis of the lower limbs clinically and by magnetic resonance imaging: many, but not all patients with sacroiliitis have spondyloarthropathy. (4/182)
OBJECTIVE: Clinical and magnetic resonance imaging (MRI) data of 170 consecutive patients with inflammatory back pain (IBP) and/or oligoarthritis of the lower limbs were evaluated in a retrospective study. The aim was to determine the frequency of sacroiliitis and spondyloarthropathy (SpA) in this population, and to assess the significance of HLA B27 measurements for diagnosis in early disease. METHODS: Pelvic X-rays were performed in all IBP patients and dynamic MRI of the sacroiliac joints in patients with IBP who had indefinite results on sacroiliac X-rays (n = 32). RESULTS: European Spondyloarthropathy Study Group criteria for SpA were fulfilled by 106/170 patients (62.4%); eight additional patients had symptoms suggestive of SpA (4.7%). The most frequent SpA subset was undifferentiated SpA (uSpA), diagnosed in 46/106 patients (43.4%). Sacroiliitis was detected by MRI in 21/32 patients with IBP and unclear X-rays (65.6%). Of those, 14 were diagnosed as SpA and seven females with moderate unilateral sacroiliitis, but no features of SpA, also not on follow-up (at least 1 yr), were classified as undifferentiated sacroiliitis (US). Ten of the 14 SpA (71.4%) and none of the seven US patients were HLA B27 positive. CONCLUSION: HLA B27 positivity in IBP patients with MRI-proven sacroiliitis positively predicts SpA. uSpA is a frequent SpA subset. There are HLA B27-negative non-SpA patients with moderate unilateral sacroiliitis whom we propose to be classified as US. (+info)Increased Ed-B fibronectin plasma levels in spondyloarthropathies: comparison with rheumatoid arthritis patients and a healthy population. (5/182)
OBJECTIVE: To determine, for the first time, plasma levels of general fibronectin (Fn) and two spliced isoforms, Ed-A and Ed-B, in patients with spondyloarthropathy (SpA) in comparison with rheumatoid arthritis (RA) patients and healthy volunteers (HV). METHODS: Plasmas (EDTA) as well as clinical data, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were collected in two groups of 10 patients fulfilling the European Spondylarthropathy Study Group criteria for SpA or the 1987 American College of Rheumatology criteria for RA. Plasmas of 21 blood donors served as controls. Plasma levels of Fns were determined by using an in-house immunocapture ELISA, using monoclonal antibodies (MAbs) against general Fn and its isoforms. RESULTS: Total Fn plasma levels were significantly higher in the SpA group (mean+/-S.D.=1387+/-569 mg/l) than in the RA group (684+/-196 mg/l; P=0.02) and in HV (303+/-211 mg/l; P<0.0001). Ed-A Fn levels appeared higher in SpA (23+/-10.4 mg/l) and RA (32.5+/-16.5 mg/l) groups than in the HV group (2.8+/-0.9 mg/l; P=0.0003 and P<0.0001, respectively), without a significant difference between SpA and RA groups. Ed-B Fn levels were higher in SpA (6.9+/-2.1 mg/l) than in RA (3.2+/-1.9 mg/l; P=0. 02) and HV (1.1+/-0.8 mg/l; P=0.0003) groups. No significant correlation was observed in SpA patients between each Fn level and clinical activity, ESR or CRP levels. CONCLUSIONS: This study showed an increase in plasma levels of Fn and Ed-B Fn in SpA patients compared with RA patients and HV, which could not be attributed solely to systemic inflammation. It may be hypothesized that Ed-A and Ed-B Fn might reflect local turnover in inflamed tissues, and that Ed-B Fn might be particularly involved in the musculoskeletal inflammatory process of SpA. (+info)Brucellar spondylitis: review of 35 cases and literature survey. (6/182)
Thirty-five patients aged 14-74 years (average, 54 years) who had brucellar spondylitis were treated between January 1991 and December 1997. The time from onset of symptoms to diagnosis of spondylitis ranged from 1 week to 8 months (median, 9 weeks). Back or neck pain (100% of patients), fever (66%), and constitutional symptoms (57%) were the most common symptoms. Cultures of blood specimens from 26 patients (74%) were positive for Brucella melitensis. The duration of antimicrobial therapy (median, 120 days; range, 45-535 days) varied according to clinical response and the presence of epidural and paravertebral masses. One of the 35 patients underwent surgical treatment of a spinal epidural abscess. Therapy failed for 9 patients (26%; 95% confidence interval [CI], 12%-43%), and 5 (14%; 95% CI, 5%-30%) had a relapse. There were no deaths or severe sequelae in this study. Brucellar spondylitis causes considerable suffering and absenteeism from work, but long-term clinical responses are favorable. (+info)Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies. (7/182)
The MHC class I protein HLA-B27 is strongly associated with susceptibility to spondyloarthropathies and can cause arthritis when expressed in rats and mice, implying a direct role in disease pathogenesis. A prominent hypothesis to explain this role suggests that the unique peptide binding specificity of HLA-B27 confers an ability to present arthritogenic peptides. The B pocket, a region of the peptide binding groove that is an important determinant of allele-specific peptide binding, is thought to be critical for arthritogenicity. However, this hypothesis remains unproven. We show that in addition to its role in peptide selection, the B pocket causes a portion of the pool of assembling HLA-B27 heavy chains in the endoplasmic reticulum to misfold, resulting in their degradation in the cytosol. The misfolding phenotype is corrected by replacing the HLA-B27 B pocket with one from HLA-A2. Our results suggest an alternative to the arthritogenic peptide hypothesis. Misfolding and its consequences, rather than allele-specific peptide presentation, may underlie the strong link between the HLA-B27 B pocket and susceptibility to spondyloarthropathies. (+info)Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term. (8/182)
OBJECTIVE: To retrospectively assess, with a sufficiently long followup (mean 11.6 years; median 9 years), the long-term outcome of chronic recurrent multifocal osteitis (CRMO), a multifocal, inflammatory bone disease. METHODS: Patients included were 8 children/adolescents and 7 adults with no family history of rheumatic disease who had been diagnosed as having CRMO between 1979 and 1995. Ten patients had undergone at least 1 bone biopsy of the lesions, with histologic examination and multiple cultures. In 1996, in addition to an in-depth interview, 12 patients underwent an extensive physical examination, laboratory evaluation, HLA-A, B, C, and DR typing, bone radiography and scintigraphy, and computed tomography scan of the sternoclavicular and sacroiliac joints. RESULTS: Remission was observed in 3 patients. The other 12 patients developed various associations of vertebral (n = 10), sacroiliac (n = 6), anterior thoracic (n = 7), peripheral articular (n = 2), enthesopathic (n = 4), or dermatologic (palmoplantar pustulosis in 3 cases and psoriasis in 2) involvements. Spine involvement was the most common and occurred the earliest (median time to appearance after the onset of osteitis 5.63 years). Clinical sacroiliitis was always unilateral. No patients carried the HLA-B27 haplotype. CRMO responded well to nonsteroidal antiinflammatory drugs. Twelve patients met the European Spondylarthropathy Study Group criteria for spondylarthopathy. CONCLUSION: After 10 years, CRMO had usually evolved to spondylarthropathy, but with certain features not usually seen in the latter: predominantly, unilateral sacroiliitis, no familial form, and no link with HLA-B27. (+info)Ankylosing spondylitis is a type of inflammatory arthritis that primarily affects the spine, although other joints can also be involved. It causes swelling in the spinal joints (vertebrae) that can lead to stiffness and pain. Over time, some of these joints may grow together, causing new bone formation and resulting in a rigid spine. This fusion of the spine is called ankylosis.
The condition typically begins in the sacroiliac joints, where the spine connects to the pelvis. From there, it can spread up the spine and potentially involve other areas of the body such as the eyes, heart, lungs, and gastrointestinal system.
Ankylosing spondylitis has a strong genetic link, with most people carrying the HLA-B27 gene. However, not everyone with this gene will develop the condition. It primarily affects males more often than females and tends to start in early adulthood.
Treatment usually involves a combination of medication, physical therapy, and exercise to help manage pain, maintain mobility, and prevent deformity. In severe cases, surgery may be considered.
Spondylitis is a term used to describe inflammation in the spinal vertebrae, often leading to stiffness and pain. The most common form is Ankylosing Spondylitis, which is a chronic autoimmune disease where the body's immune system mistakenly attacks the joints in the spine. This can cause the bones in the spine to grow together, resulting in a rigid and inflexible spine. Other forms of spondylitis include reactive spondylitis, infectious spondylitis, and seronegative spondyloarthropathies. Symptoms may also include pain and stiffness in the neck, lower back, hips, and small joints of the body.
HLA-B27 antigen is a type of human leukocyte antigen (HLA) found on the surface of white blood cells. HLAs are proteins that help the body's immune system distinguish its own cells from foreign substances such as viruses and bacteria.
HLA-B27 is a specific type of HLA-B antigen, which is part of the major histocompatibility complex (MHC) class I molecules. The presence of HLA-B27 antigen can be inherited from parents to their offspring.
While most people with the HLA-B27 antigen do not develop any health problems, this antigen is associated with an increased risk of developing certain inflammatory diseases, particularly spondyloarthritis, a group of disorders that affect the joints and spine. Examples of these conditions include ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and enteropathic arthritis associated with inflammatory bowel disease. However, not everyone with HLA-B27 will develop these diseases, and many people without the antigen can still develop spondyloarthritis.
The sacroiliac (SI) joint is the joint that connects the iliac bone (part of the pelvis) and the sacrum (the triangular bone at the base of the spine). There are two sacroiliac joints, one on each side of the spine. The primary function of these joints is to absorb shock between the upper body and lower body and distribute the weight of the upper body to the lower body. They also provide a small amount of movement to allow for flexibility when walking or running. The SI joints are supported and stabilized by strong ligaments, muscles, and bones.
The spine, also known as the vertebral column, is a complex structure in the human body that is part of the axial skeleton. It is composed of 33 individual vertebrae (except in some people where there are fewer due to fusion of certain vertebrae), intervertebral discs, facet joints, ligaments, muscles, and nerves.
The spine has several important functions:
1. Protection: The spine protects the spinal cord, which is a major component of the nervous system, by enclosing it within a bony canal.
2. Support: The spine supports the head and upper body, allowing us to maintain an upright posture and facilitating movement of the trunk and head.
3. Movement: The spine enables various movements such as flexion (bending forward), extension (bending backward), lateral flexion (bending sideways), and rotation (twisting).
4. Weight-bearing: The spine helps distribute weight and pressure evenly across the body, reducing stress on individual vertebrae and other structures.
5. Blood vessel and nerve protection: The spine protects vital blood vessels and nerves that pass through it, including the aorta, vena cava, and spinal nerves.
The spine is divided into five regions: cervical (7 vertebrae), thoracic (12 vertebrae), lumbar (5 vertebrae), sacrum (5 fused vertebrae), and coccyx (4 fused vertebrae, also known as the tailbone). Each region has unique characteristics that allow for specific functions and adaptations to the body's needs.
Spondylarthritis is a term used to describe a group of interrelated inflammatory diseases that primarily affect the spine and sacroiliac joints (where the spine connects to the pelvis), but can also involve other joints, ligaments, tendons, and entheses (sites where tendons or ligaments attach to bones). These conditions share common genetic, clinical, and imaging features.
The most common forms of spondylarthritis include:
1. Ankylosing spondylitis - a chronic inflammatory disease that primarily affects the spine and sacroiliac joints, causing pain and stiffness. In some cases, it can lead to fusion of the spine's vertebrae.
2. Psoriatic arthritis - a form of arthritis that occurs in people with psoriasis, an autoimmune skin condition. It can cause inflammation in the joints, tendons, and entheses.
3. Reactive arthritis - a type of arthritis that develops as a reaction to an infection in another part of the body, often the urinary or gastrointestinal tract.
4. Enteropathic arthritis - a form of arthritis associated with inflammatory bowel diseases like Crohn's disease and ulcerative colitis.
5. Undifferentiated spondylarthritis - when a patient presents with features of spondylarthritis but does not meet the criteria for any specific subtype.
Common symptoms of spondylarthritis include:
- Back pain and stiffness, often worse in the morning or after periods of inactivity
- Peripheral joint pain and swelling
- Enthesitis (inflammation at tendon or ligament insertion points)
- Dactylitis (swelling of an entire finger or toe)
- Fatigue
- Uveitis (inflammation of the eye)
- Skin rashes, such as psoriasis
- Inflammatory bowel disease symptoms
Diagnosis typically involves a combination of medical history, physical examination, laboratory tests, and imaging studies. Treatment often includes nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), biologic agents, and lifestyle modifications to manage symptoms and prevent joint damage.
Antirheumatic agents are a class of drugs used to treat rheumatoid arthritis, other inflammatory types of arthritis, and related conditions. These medications work by reducing inflammation in the body, relieving symptoms such as pain, swelling, and stiffness in the joints. They can also help slow down or prevent joint damage and disability caused by the disease.
There are several types of antirheumatic agents, including:
1. Nonsteroidal anti-inflammatory drugs (NSAIDs): These medications, such as ibuprofen and naproxen, reduce inflammation and relieve pain. They are often used to treat mild to moderate symptoms of arthritis.
2. Corticosteroids: These powerful anti-inflammatory drugs, such as prednisone and cortisone, can quickly reduce inflammation and suppress the immune system. They are usually used for short-term relief of severe symptoms or in combination with other antirheumatic agents.
3. Disease-modifying antirheumatic drugs (DMARDs): These medications, such as methotrexate and hydroxychloroquine, work by slowing down the progression of rheumatoid arthritis and preventing joint damage. They can take several weeks or months to become fully effective.
4. Biologic response modifiers (biologics): These are a newer class of DMARDs that target specific molecules involved in the immune response. They include drugs such as adalimumab, etanercept, and infliximab. Biologics are usually used in combination with other antirheumatic agents for patients who have not responded to traditional DMARD therapy.
5. Janus kinase (JAK) inhibitors: These medications, such as tofacitinib and baricitinib, work by blocking the action of enzymes called JAKs that are involved in the immune response. They are used to treat moderate to severe rheumatoid arthritis and can be used in combination with other antirheumatic agents.
It is important to note that antirheumatic agents can have significant side effects and should only be prescribed by a healthcare provider who is experienced in the management of rheumatoid arthritis. Regular monitoring and follow-up are essential to ensure safe and effective treatment.
Spondylarthropathies is a term used to describe a group of interrelated inflammatory diseases that primarily affect the joints of the spine (vertebral column) and the sites where the ligaments and tendons attach to the bones (entheses). These conditions also often have associations with extra-articular features, such as skin, eye, and intestinal manifestations. The most common spondylarthropathies are ankylosing spondylitis, psoriatic arthritis, reactive arthritis (formerly known as Reiter's syndrome), enteropathic arthritis (associated with inflammatory bowel disease), and undifferentiated spondyloarthropathies.
The primary hallmark of these conditions is enthesitis, which is an inflammation at the sites where ligaments or tendons attach to bones. This can lead to pain, stiffness, and limited mobility in the affected areas, particularly in the spine and sacroiliac joints (the joints that connect the base of the spine to the pelvis).
Spondylarthropathies have a strong genetic association with the human leukocyte antigen B27 (HLA-B27) gene. However, not all individuals with this gene will develop spondylarthropathies, and many people without the gene can still be affected by these conditions.
Early diagnosis and appropriate treatment of spondylarthropathies are essential to help manage symptoms, prevent joint damage, and maintain mobility and quality of life. Treatment options typically include a combination of medications, physical therapy, and lifestyle modifications.
Blood sedimentation, also known as erythrocyte sedimentation rate (ESR), is a medical test that measures the rate at which red blood cells settle at the bottom of a tube of unclotted blood over a specific period of time. The test is used to detect and monitor inflammation in the body.
During an acute inflammatory response, certain proteins in the blood, such as fibrinogen, increase in concentration. These proteins cause red blood cells to stick together and form rouleaux (stacks of disc-shaped cells). As a result, the red blood cells settle more quickly, leading to a higher ESR.
The ESR test is a non-specific test, meaning that it does not identify the specific cause of inflammation. However, it can be used as an indicator of underlying conditions such as infections, autoimmune diseases, and cancer. The test is also used to monitor the effectiveness of treatment for these conditions.
The ESR test is usually performed by drawing a sample of blood into a special tube and allowing it to sit undisturbed for one hour. The distance that the red blood cells have settled is then measured and recorded as the ESR. Normal values for ESR vary depending on age and gender, with higher values indicating greater inflammation.
Arthritis is a medical condition characterized by inflammation in one or more joints, leading to symptoms such as pain, stiffness, swelling, and reduced range of motion. There are many different types of arthritis, including osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, and lupus, among others.
Osteoarthritis is the most common form of arthritis and is caused by wear and tear on the joints over time. Rheumatoid arthritis, on the other hand, is an autoimmune disorder in which the body's immune system mistakenly attacks the joint lining, causing inflammation and damage.
Arthritis can affect people of all ages, including children, although it is more common in older adults. Treatment for arthritis may include medications to manage pain and reduce inflammation, physical therapy, exercise, and in some cases, surgery.
Iritis is a medical condition that refers to the inflammation of the iris, which is the colored part of the eye. The iris controls the size of the pupil and thus regulates the amount of light that enters the eye. Iritis can cause symptoms such as eye pain, redness, photophobia (sensitivity to light), blurred vision, and headaches. It is often treated with anti-inflammatory medications and may require prompt medical attention to prevent complications such as glaucoma or vision loss. The underlying cause of iritis can vary and may include infections, autoimmune diseases, trauma, or other conditions.
A Severity of Illness Index is a measurement tool used in healthcare to assess the severity of a patient's condition and the risk of mortality or other adverse outcomes. These indices typically take into account various physiological and clinical variables, such as vital signs, laboratory values, and co-morbidities, to generate a score that reflects the patient's overall illness severity.
Examples of Severity of Illness Indices include the Acute Physiology and Chronic Health Evaluation (APACHE) system, the Simplified Acute Physiology Score (SAPS), and the Mortality Probability Model (MPM). These indices are often used in critical care settings to guide clinical decision-making, inform prognosis, and compare outcomes across different patient populations.
It is important to note that while these indices can provide valuable information about a patient's condition, they should not be used as the sole basis for clinical decision-making. Rather, they should be considered in conjunction with other factors, such as the patient's overall clinical presentation, treatment preferences, and goals of care.
Tuberculosis (TB) of the spine, also known as Pott's disease, is a specific form of extrapulmonary tuberculosis that involves the vertebral column. It is caused by the Mycobacterium tuberculosis bacterium, which primarily affects the lungs but can spread through the bloodstream to other parts of the body, including the spine.
In Pott's disease, the infection leads to the destruction of the spongy bone (vertebral body) and the intervertebral disc space, resulting in vertebral collapse, kyphosis (hunchback deformity), and potential neurological complications due to spinal cord compression. Common symptoms include back pain, stiffness, fever, night sweats, and weight loss. Early diagnosis and treatment with a multidrug antibiotic regimen are crucial to prevent long-term disability and further spread of the infection.
Reactive arthritis is a form of inflammatory arthritis that occurs in response to an infection in another part of the body, such as the genitals, urinary tract, or gastrointestinal tract. It is also known as Reiter's syndrome. The symptoms of reactive arthritis include joint pain and swelling, typically affecting the knees, ankles, and feet; inflammation of the eyes, skin, and mucous membranes; and urethritis or cervicitis. It is more common in men than women and usually develops within 1-4 weeks after a bacterial infection. The diagnosis is made based on the symptoms, medical history, physical examination, and laboratory tests. Treatment typically includes antibiotics to eliminate the underlying infection and medications to manage the symptoms of arthritis.
Psoriatic arthritis is a form of inflammatory arthritis that occurs in some people with psoriasis, a skin condition characterized by scaly, red, and itchy patches. The Arthritis Foundation defines psoriatic arthritis as "a chronic disease characterized by swelling, pain, and stiffness in and around the joints. It usually affects the fingers and toes but can also affect the lower back, knees, ankles, and spine."
Psoriatic arthritis can cause a variety of symptoms, including:
* Joint pain, swelling, and stiffness
* Swollen fingers or toes (dactylitis)
* Tenderness, pain, and swelling where tendons and ligaments attach to bones (enthesitis)
* Changes in nail growth, such as pitting, ridging, or separation from the nail bed
* Fatigue and weakness
* Reduced range of motion and mobility
The exact cause of psoriatic arthritis is not fully understood, but it is believed to involve a combination of genetic, environmental, and immune system factors. Treatment typically involves a combination of medications, lifestyle changes, and physical therapy to manage symptoms and prevent joint damage.
Rheumatic diseases are a group of disorders that cause pain, stiffness, and swelling in the joints, muscles, tendons, ligaments, or bones. They include conditions such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus (SLE), gout, ankylosing spondylitis, psoriatic arthritis, and many others. These diseases can also affect other body systems including the skin, eyes, lungs, heart, kidneys, and nervous system. Rheumatic diseases are often chronic and may be progressive, meaning they can worsen over time. They can cause significant pain, disability, and reduced quality of life if not properly diagnosed and managed. The exact causes of rheumatic diseases are not fully understood, but genetics, environmental factors, and immune system dysfunction are believed to play a role in their development.
Balneology is a branch of medicine that deals with the therapeutic use of bathing, particularly in natural mineral waters or medicinal mud. It involves the study and application of various methods of hydrotherapy, including the use of hot springs, mineral baths, and other types of water-based treatments to promote health, prevent illness, and alleviate symptoms of certain medical conditions.
Balneotherapy is a common form of treatment used in balneology, which involves immersing the body in warm or hot mineral waters, often with the addition of therapeutic agents such as mud or essential oils. The minerals present in these waters can have various beneficial effects on the body, including improving circulation, reducing inflammation, and promoting relaxation.
Balneology is often used to treat a variety of conditions, including arthritis, rheumatism, skin disorders, respiratory ailments, and stress-related disorders. It can also be used as a form of preventative medicine, helping to boost the immune system and improve overall health and wellbeing.
Anterior uveitis is a medical term that refers to the inflammation of the front portion of the uvea, which is the middle layer of the eye. The uvea includes the iris (the colored part of the eye), the ciliary body (a structure behind the iris that helps focus light onto the retina), and the choroid (a layer of blood vessels that supplies oxygen and nutrients to the retina).
Anterior uveitis is characterized by inflammation of the iris and/or the ciliary body, leading to symptoms such as redness, pain, sensitivity to light, blurred vision, and a small pupil. The condition can be caused by various factors, including infections, autoimmune diseases, trauma, or unknown causes (idiopathic).
Treatment of anterior uveitis typically involves the use of topical corticosteroids to reduce inflammation and cycloplegics to relieve pain and prevent spasms of the ciliary muscle. In some cases, oral medications may be necessary to control the inflammation. Prompt treatment is important to prevent complications such as glaucoma, cataracts, or permanent vision loss.
The lumbar vertebrae are the five largest and strongest vertebrae in the human spine, located in the lower back region. They are responsible for bearing most of the body's weight and providing stability during movement. The lumbar vertebrae have a characteristic shape, with a large body in the front, which serves as the main weight-bearing structure, and a bony ring in the back, formed by the pedicles, laminae, and processes. This ring encloses and protects the spinal cord and nerves. The lumbar vertebrae are numbered L1 to L5, starting from the uppermost one. They allow for flexion, extension, lateral bending, and rotation movements of the trunk.
Kyphosis is a medical term used to describe an excessive curvature of the spine in the sagittal plane, leading to a rounded or humped back appearance. This condition often affects the thoracic region of the spine and can result from various factors such as age-related degenerative changes, congenital disorders, Scheuermann's disease, osteoporosis, or traumatic injuries. Mild kyphosis may not cause any significant symptoms; however, severe cases can lead to pain, respiratory difficulties, and decreased quality of life. Treatment options typically include physical therapy, bracing, and, in some cases, surgical intervention.
Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. It is characterized by persistent inflammation, synovial hyperplasia, and subsequent damage to the articular cartilage and bone. The immune system mistakenly attacks the body's own tissues, specifically targeting the synovial membrane lining the joint capsule. This results in swelling, pain, warmth, and stiffness in affected joints, often most severely in the hands and feet.
RA can also have extra-articular manifestations, affecting other organs such as the lungs, heart, skin, eyes, and blood vessels. The exact cause of RA remains unknown, but it is believed to involve a complex interplay between genetic susceptibility and environmental triggers. Early diagnosis and treatment are crucial in managing rheumatoid arthritis to prevent joint damage, disability, and systemic complications.
The thoracic vertebrae are the 12 vertebrae in the thoracic region of the spine, which is the portion between the cervical and lumbar regions. These vertebrae are numbered T1 to T12, with T1 being closest to the skull and T12 connecting to the lumbar region.
The main function of the thoracic vertebrae is to provide stability and support for the chest region, including protection for the vital organs within, such as the heart and lungs. Each thoracic vertebra has costal facets on its sides, which articulate with the heads of the ribs, forming the costovertebral joints. This connection between the spine and the ribcage allows for a range of movements while maintaining stability.
The thoracic vertebrae have a unique structure compared to other regions of the spine. They are characterized by having long, narrow bodies, small bony processes, and prominent spinous processes that point downwards. This particular shape and orientation of the thoracic vertebrae contribute to their role in limiting excessive spinal movement and providing overall trunk stability.
HLA (Human Leukocyte Antigen) antigens are a group of proteins found on the surface of cells in our body. They play a crucial role in the immune system's ability to differentiate between "self" and "non-self." HLA antigens are encoded by a group of genes located on chromosome 6, known as the major histocompatibility complex (MHC).
There are three types of HLA antigens: HLA class I, HLA class II, and HLA class III. HLA class I antigens are found on the surface of almost all cells in the body and help the immune system recognize and destroy virus-infected or cancerous cells. They consist of three components: HLA-A, HLA-B, and HLA-C.
HLA class II antigens are primarily found on the surface of immune cells, such as macrophages, B cells, and dendritic cells. They assist in the presentation of foreign particles (like bacteria and viruses) to CD4+ T cells, which then activate other parts of the immune system. HLA class II antigens include HLA-DP, HLA-DQ, and HLA-DR.
HLA class III antigens consist of various molecules involved in immune responses, such as cytokines and complement components. They are not directly related to antigen presentation.
The genetic diversity of HLA antigens is extensive, with thousands of variations or alleles. This diversity allows for a better ability to recognize and respond to a wide range of pathogens. However, this variation can also lead to compatibility issues in organ transplantation, as the recipient's immune system may recognize the donor's HLA antigens as foreign and attack the transplanted organ.
The cervical vertebrae are the seven vertebrae that make up the upper part of the spine, also known as the neck region. They are labeled C1 to C7, with C1 being closest to the skull and C7 connecting to the thoracic vertebrae in the chest region. The cervical vertebrae have unique structures to allow for a wide range of motion in the neck while also protecting the spinal cord and providing attachment points for muscles and ligaments.
Immunoglobulin G (IgG) is a type of antibody, which is a protective protein produced by the immune system in response to foreign substances like bacteria or viruses. IgG is the most abundant type of antibody in human blood, making up about 75-80% of all antibodies. It is found in all body fluids and plays a crucial role in fighting infections caused by bacteria, viruses, and toxins.
IgG has several important functions:
1. Neutralization: IgG can bind to the surface of bacteria or viruses, preventing them from attaching to and infecting human cells.
2. Opsonization: IgG coats the surface of pathogens, making them more recognizable and easier for immune cells like neutrophils and macrophages to phagocytose (engulf and destroy) them.
3. Complement activation: IgG can activate the complement system, a group of proteins that work together to help eliminate pathogens from the body. Activation of the complement system leads to the formation of the membrane attack complex, which creates holes in the cell membranes of bacteria, leading to their lysis (destruction).
4. Antibody-dependent cellular cytotoxicity (ADCC): IgG can bind to immune cells like natural killer (NK) cells and trigger them to release substances that cause target cells (such as virus-infected or cancerous cells) to undergo apoptosis (programmed cell death).
5. Immune complex formation: IgG can form immune complexes with antigens, which can then be removed from the body through various mechanisms, such as phagocytosis by immune cells or excretion in urine.
IgG is a critical component of adaptive immunity and provides long-lasting protection against reinfection with many pathogens. It has four subclasses (IgG1, IgG2, IgG3, and IgG4) that differ in their structure, function, and distribution in the body.
Osteitis is a medical term that refers to the inflammation of bone tissue. It can occur as a result of various conditions, such as infection (osteomyelitis), trauma, or autoimmune disorders. The symptoms of osteitis may include pain, swelling, warmth, and redness in the affected area, as well as fever and general malaise. Treatment typically involves addressing the underlying cause of the inflammation, which may involve antibiotics for infection or anti-inflammatory medications for other causes. In some cases, surgery may be necessary to remove infected or damaged bone tissue.
Sulfasalazine is defined as a medication that is commonly used to treat inflammatory bowel disease (IBD), such as ulcerative colitis and Crohn's disease. It is also used in the treatment of rheumatoid arthritis. Sulfasalazine has an anti-inflammatory effect, which helps to reduce inflammation in the gut or joints.
The medication contains two components: sulfapyridine and 5-aminosalicylic acid (5-ASA). The sulfapyridine component is an antibiotic that may help to reduce the number of harmful bacteria in the gut, while the 5-ASA component is responsible for the anti-inflammatory effect.
Sulfasalazine works by being broken down into its two components after it is ingested. The 5-ASA component then acts directly on the lining of the gut to reduce inflammation, while the sulfapyridine component is absorbed into the bloodstream and excreted in the urine.
Common side effects of sulfasalazine include nausea, vomiting, heartburn, headache, and loss of appetite. Less common but more serious side effects may include allergic reactions, liver or kidney problems, and blood disorders. It is important to take sulfasalazine exactly as directed by a healthcare provider and to report any concerning symptoms promptly.
Non-steroidal anti-inflammatory agents (NSAIDs) are a class of medications that reduce pain, inflammation, and fever. They work by inhibiting the activity of cyclooxygenase (COX) enzymes, which are involved in the production of prostaglandins, chemicals that contribute to inflammation and cause blood vessels to dilate and become more permeable, leading to symptoms such as pain, redness, warmth, and swelling.
NSAIDs are commonly used to treat a variety of conditions, including arthritis, muscle strains and sprains, menstrual cramps, headaches, and fever. Some examples of NSAIDs include aspirin, ibuprofen, naproxen, and celecoxib.
While NSAIDs are generally safe and effective when used as directed, they can have side effects, particularly when taken in large doses or for long periods of time. Common side effects include stomach ulcers, gastrointestinal bleeding, and increased risk of heart attack and stroke. It is important to follow the recommended dosage and consult with a healthcare provider if you have any concerns about using NSAIDs.
Back pain is a common symptom characterized by discomfort or soreness in the back, often occurring in the lower region of the back (lumbago). It can range from a mild ache to a sharp stabbing or shooting pain, and it may be accompanied by stiffness, restricted mobility, and difficulty performing daily activities. Back pain is typically caused by strain or sprain to the muscles, ligaments, or spinal joints, but it can also result from degenerative conditions, disc herniation, spinal stenosis, osteoarthritis, or other medical issues affecting the spine. The severity and duration of back pain can vary widely, with some cases resolving on their own within a few days or weeks, while others may require medical treatment and rehabilitation.
Pseudarthrosis is a medical term that refers to a false joint or a nonunion of bones, meaning that the broken bone ends do not heal properly and continue to move at the fracture site. This condition can cause pain, instability, and deformity in the affected limb. It may require additional treatment such as surgery to promote bone healing and stabilization.
Tumor Necrosis Factor (TNF) Receptors are cell surface receptors that bind to tumor necrosis factor cytokines. They play crucial roles in the regulation of a variety of immune cell functions, including inflammation, immunity, and cell survival or death (apoptosis).
There are two major types of TNF receptors: TNFR1 (also known as p55 or CD120a) and TNFR2 (also known as p75 or CD120b). TNFR1 is widely expressed in most tissues, while TNFR2 has a more restricted expression pattern and is mainly found on immune cells.
TNF receptors have an intracellular domain called the death domain, which can trigger signaling pathways leading to apoptosis when activated by TNF ligands. However, they can also activate other signaling pathways that promote cell survival, differentiation, and inflammation. Dysregulation of TNF receptor signaling has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative conditions.
Spinal diseases refer to a range of medical conditions that affect the spinal column, which is made up of vertebrae (bones), intervertebral discs, facet joints, nerves, ligaments, and muscles. These diseases can cause pain, discomfort, stiffness, numbness, weakness, or even paralysis, depending on the severity and location of the condition. Here are some examples of spinal diseases:
1. Degenerative disc disease: This is a condition where the intervertebral discs lose their elasticity and height, leading to stiffness, pain, and decreased mobility.
2. Herniated disc: This occurs when the inner material of the intervertebral disc bulges or herniates out through a tear in the outer layer, causing pressure on the spinal nerves and resulting in pain, numbness, tingling, or weakness in the affected area.
3. Spinal stenosis: This is a narrowing of the spinal canal or the neural foramen (the openings where the spinal nerves exit the spinal column), which can cause pressure on the spinal cord or nerves and result in pain, numbness, tingling, or weakness.
4. Scoliosis: This is a curvature of the spine that can occur in children or adults, leading to an abnormal posture, back pain, and decreased lung function.
5. Osteoarthritis: This is a degenerative joint disease that affects the facet joints in the spine, causing pain, stiffness, and decreased mobility.
6. Ankylosing spondylitis: This is a chronic inflammatory disease that affects the spine and sacroiliac joints, leading to pain, stiffness, and fusion of the vertebrae.
7. Spinal tumors: These are abnormal growths that can occur in the spinal column, which can be benign or malignant, causing pain, neurological symptoms, or even paralysis.
8. Infections: Bacterial or viral infections can affect the spine, leading to pain, fever, and other systemic symptoms.
9. Trauma: Fractures, dislocations, or sprains of the spine can occur due to accidents, falls, or sports injuries, causing pain, neurological deficits, or even paralysis.
Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.
Sacroiliitis is a medical condition characterized by inflammation of one or both of the sacroiliac joints, which connect the spine's sacrum to the hip bones (ilium). This inflammation can cause pain in the lower back, hips, and legs, and may be accompanied by stiffness and difficulty walking. Sacroiliitis can be caused by various factors, including mechanical stress, trauma, infectious diseases, or underlying inflammatory conditions such as ankylosing spondylitis. The diagnosis of sacroiliitis typically involves a combination of physical examination, medical history, imaging studies, and laboratory tests to determine the underlying cause and appropriate treatment.
Monoclonal antibodies are a type of antibody that are identical because they are produced by a single clone of cells. They are laboratory-produced molecules that act like human antibodies in the immune system. They can be designed to attach to specific proteins found on the surface of cancer cells, making them useful for targeting and treating cancer. Monoclonal antibodies can also be used as a therapy for other diseases, such as autoimmune disorders and inflammatory conditions.
Monoclonal antibodies are produced by fusing a single type of immune cell, called a B cell, with a tumor cell to create a hybrid cell, or hybridoma. This hybrid cell is then able to replicate indefinitely, producing a large number of identical copies of the original antibody. These antibodies can be further modified and engineered to enhance their ability to bind to specific targets, increase their stability, and improve their effectiveness as therapeutic agents.
Monoclonal antibodies have several mechanisms of action in cancer therapy. They can directly kill cancer cells by binding to them and triggering an immune response. They can also block the signals that promote cancer growth and survival. Additionally, monoclonal antibodies can be used to deliver drugs or radiation directly to cancer cells, increasing the effectiveness of these treatments while minimizing their side effects on healthy tissues.
Monoclonal antibodies have become an important tool in modern medicine, with several approved for use in cancer therapy and other diseases. They are continuing to be studied and developed as a promising approach to treating a wide range of medical conditions.
Klebsiella is a genus of Gram-negative, facultatively anaerobic, encapsulated, non-motile, rod-shaped bacteria that are part of the family Enterobacteriaceae. They are commonly found in the normal microbiota of the mouth, skin, and intestines, but can also cause various types of infections, particularly in individuals with weakened immune systems.
Klebsiella pneumoniae is the most common species and can cause pneumonia, urinary tract infections, bloodstream infections, and wound infections. Other Klebsiella species, such as K. oxytoca, can also cause similar types of infections. These bacteria are resistant to many antibiotics, making them difficult to treat and a significant public health concern.
A psoas abscess is a localized collection of pus (infectious material) in the iliopsoas muscle compartment, which consists of the psoas major and iliacus muscles. These muscles are located in the lower back and pelvis, responsible for flexing the hip joint.
Psoas abscesses can be classified as primary or secondary:
1. Primary psoas abscess: This type is caused by hematogenous spread (dissemination through the blood) of a bacterial infection from a distant site, often involving the gastrointestinal tract, genitourinary system, or skin. It is less common and typically seen in individuals with compromised immune systems.
2. Secondary psoas abscess: This type is caused by direct extension of an infection from a nearby anatomical structure, such as the spine, vertebral column, or retroperitoneal space (the area behind the peritoneum, the lining of the abdominal cavity). Common causes include spinal osteomyelitis (spinal bone infection), discitis (infection of the intervertebral disc), or a perforated viscus (a hole in an organ like the bowel).
Symptoms of a psoas abscess may include lower back pain, hip pain, fever, chills, and difficulty walking. Diagnosis typically involves imaging studies such as CT scans or MRIs, which can confirm the presence and extent of the abscess. Treatment usually consists of antibiotic therapy and drainage of the abscess, often through a percutaneous (through the skin) approach guided by imaging. In some cases, surgical intervention may be necessary for adequate drainage and management.
Spondylitis
Ankylosing spondylitis
Ankylosing Spondylitis Quality of Life
List of people with ankylosing spondylitis
Photophobia
Arthritis
List of patient-reported quality of life surveys
Bone
Knee pain
Allan George Williams Whitfield
James Baird (British Army officer)
List of autoimmune diseases
Chemotherapy
Christa Reinig
William Copeman
Johann Nepomuk Rust
Dagger sign
Leonard Trask
Dennis Hood
HLA-B
Spinal enthesopathy
Minimal important difference
Joe Perry (snooker player)
Fibrous ankylosis
1893 in science
Klebsiella
HLA-B27
Axial spondyloarthritis
Bernard Connor
Ankylosis
Spondylitis - Wikipedia
Ankylosing Spondylitis | MedlinePlus
Understanding Ankylosing Spondylitis -- Symptoms
Ankylosing spondylitis: Tests, diagnosis, and treatment
Ankylosing spondylitis and asthma: The connections
Biologics for Ankylosing Spondylitis
Susceptibility to ankylosing spondylitis
The Progression of Ankylosing Spondylitis
Ankylosing Spondylitis Fact Sheet - Bristol Myers Squibb
Pott Disease (Tuberculous [TB] Spondylitis): Background, Pathophysiology, Epidemiology
Osteotomies in ankylosing spondylitis: where, how many, and how much?
Ankylosing spondylitis: Understand your treatment options - Mayo Clinic
Spondylitis Educational Webinar with Nancy O'Brien, "Mind Body Approaches to Pain" Survey
Cervical Spondylitis</span><i class="icon" aria-hidden=...
Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy Clinical Presentation: History, Physical Examination
Ankylosing spondylitis - Simple English Wikipedia, the free encyclopedia
Ankylosing Spondylitis Basics: For More Information
Best Yoga Moves for Ankylosing Spondylitis
Manage Pain in Spondylitis | SPONDYLITIS.ORG
Ankylosing Spondylitis in Women: Symptoms and More
Ankylosing Spondylitis Not Linked to Axial Psoriatic Arthritis
Listeria monocytogenes associated with pyogenic spondylitis in a 92-year-old woman | CMAJ
Ankylosing Spondylitis: Causes, Treatment | HSS Rheumatology
ankylosing spondylitis - Impact 89FM | WDBM-FM
School Attendance Archives - Spondylitis Association of America - Ankylosing Spondylitis
Ankylosing Spondylitis Basics: Diagnosis, Treatment, and Steps to Take
Overview | TNF-alpha inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis | Guidance | NICE
Marie-Strümpell Spondylitis in Women | Annals of the Rheumatic Diseases
British Library EThOS: Molecular studies in ankylosing spondylitis and rheumatoid arthritis.
Association of America1
- As a service to the spondyloarthritis community, the Spondylitis Association of America is proud to host free seminars around the United States, and virtual, online podcasts you can attend from anywhere. (spondylitis.org)
Active ankylosing3
- These drugs are for people with severe active ankylosing spondylitis or severe non-radiographic axial spondyloarthritis who have tried non-steroidal anti-inflammatory drugs (NSAIDs), but they have not worked. (nice.org.uk)
- NICE are recommending it as an option to treat adults with active ankylosing spondylitis (AS) who have responded inadequately to conventional therapy. (europeanpharmaceuticalreview.com)
- This subanalysis of the RHAPSODY study (Review of Safety and Effectiveness with Adalimumab in Patients with Active Ankylosing Spondylitis) was conducted to evaluate the effect of adalimumab on sleep in patients with active AS. (jrheum.org)
Rheumatoid arthritis6
- British Library EThOS: Molecular studies in ankylosing spondylitis and rheumatoid arthritis. (bl.uk)
- Molecular studies in ankylosing spondylitis and rheumatoid arthritis. (bl.uk)
- Blankenberg-Sprenkels SD, Fielder M, Feltkamp TW et al (1998) Antibodies to Klebsiella pneumoniae in Dutch patients with ankylosing spondylitis and acute anterior uveitis and to Proteus mirabilis in rheumatoid arthritis. (springer.com)
- Chou CT, Uksila J, Toivanen P (1998) Enterobacterial antibodies in Chinese patients with rheumatoid arthritis and ankylosing spondylitis. (springer.com)
- Seventeen Janssen Immunology abstracts in ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis and psoriasis, will be presented at EULAR. (europeanpharmaceuticalreview.com)
- CIRD was defined as the presence of rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), or systemic lupus erythematosus. (lu.se)
Rheumatology2
- Psoriasis in ankylosing spondylitis (AS) is not related to axial psoriatic arthritis (PsA), a type of psoriasis that causes lower back inflammation and pain similar to AS, according to a study published in Rheumatology . (pharmacytimes.com)
- A Clinician's Pearls and Myths in Rheumatology Ankylosing Spondylitis %22&body=%0AI%20found%20an%20article%20you%20might%20be%20interested%20in. (deepdyve.com)
Management of ankylosing2
- Braun J, van den Berg R, Baraliakos X et al (2011) 2010 update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. (springer.com)
- This first update of the ASAS/EULAR recommendations on the management of ankylosing spondylitis (AS) is based on the original paper, a systematic review of existing recommendations and the literature since 2005 and the discussion and agreement among 21 international experts, 2 patients and 2 physiotherapists in a meeting in February 2010. (bmj.com)
Spine21
- Ankylosing spondylitis (pronounced ank-kih-low-sing spon-dill-eye-tiss), or AS, is a form of arthritis that primarily affects the spine, although other joints can become involved. (wikipedia.org)
- Ankylosing spondylitis is a type of arthritis of the spine. (medlineplus.gov)
- Not everyone develops all of the following symptoms of ankylosing spondylitis , arthritis of the spine. (webmd.com)
- Although there's no cure for ankylosing spondylitis - a type of arthritis that affects the spine - treatment can ease your symptoms and possibly slow the progression of the disease. (mayoclinic.org)
- Cervical spondylitis is an autoimmune disease of the upper (cervical) spine. (nuffieldhealth.com)
- Ankylosing spondylitis (AS) inflames the sacroiliac joints located between the base of the spine and pelvis from there the disease starts and gradually captures the entire spinal cord and there is complete tilt in the body. (wikipedia.org)
- The term "ankylosing spondylitis" (AS) may sound like a newly discovered dinosaur species, but in reality it's a form of arthritis that attacks your spine. (greatist.com)
- Fat suppressed, weighted magnetic resonance imaging of the lumbar spine of a 92-year-old woman, showing hyperintensity of the L1/2 vertebrae and discus, consistent with pyogenic spondylitis. (cmaj.ca)
- Ankylosing spondylitis is a form of spondyloarthritis that causes inflammation primarily in the spine, sternum, and large joints in the body. (hss.edu)
- Ankylosing spondylitis (AS) is a chronic, inflammatory disorder that particularly affects the spine. (hss.edu)
- Spondylitis" refers specifically to the inflammatory process ("itis") of the spine. (hss.edu)
- Brucellar Spondylitis (BS) is an infectious spondylitis caused by a zoonotic, infectious brucella invading the spine. (scirp.org)
- Yu, David Tak Yan 2009-01-01 00:00:00 [Ankylosing spondylitis (AS) is the prototypical form of the spondyloarthritides, a group of disorders that involves inflammation of the sacroiliac joints, spine, joints, and entheses, as well as extraspinal lesions of the eye, bowel, and heart. (deepdyve.com)
- Ankylosing spondylitis (AS) is the prototypical form of the spondyloarthritides, a group of disorders that involves inflammation of the sacroiliac joints, spine, joints, and entheses, as well as extraspinal lesions of the eye, bowel, and heart. (deepdyve.com)
- Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease that characteristically affects the sacroiliac joints and the spine. (molvis.org)
- Ankylosing" means fusing together and "spondylitis" means inflammation of the spine which causes stiffness, tenderness and discomfort. (arthritisireland.ie)
- Ankylosing spondylitis is a type of arthritis that makes your spine painful and stiff. (msdmanuals.com)
- Ankylosing spondylitis is a disease that is inflammatory in nature that causes vertebrae within the spine to fuse together. (planetdrugsdirect.com)
- When a person believes that they have ankylosing spondylitis or they are experiencing pain within their spine, going to the doctor is critical. (planetdrugsdirect.com)
- In patients with ankylosing spondylitis (not non-radiographic axial SpA), initial conventional radiography of the lumbar and cervical spine can detect syndesmophytes, which are predictive of development of new syndesmophytes. (medscape.com)
- In the spine, the early stages of spondylitis are manifested as small erosions at the corners of the vertebral bodies. (medscape.com)
Treat ankylosing4
- Different types of medications are used to treat ankylosing spondylitis (AS). (healthline.com)
- The five TNF blockers approved by the FDA to treat ankylosing spondylitis are adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi) and infliximab (Remicade). (mayoclinic.org)
- How do doctors treat ankylosing spondylitis? (msdmanuals.com)
- Does Celecoxib (Celebrex) Treat Ankylosing Spondylitis? (planetdrugsdirect.com)
Pain and stiffness4
- Ankylosing spondylitis usually starts with pain and stiffness in the back, after times of inactivity. (mayoclinic.org)
- Cervical spondylitis inflames these joints causing pain and stiffness. (nuffieldhealth.com)
- Ankylosing spondylitis is a chronic inflammatory rheumatic disease that causes pain and stiffness and is often accompanied by poor sleep, fatigue, stress, anxiety, and depression. (everydayhealth.com)
- Symptoms of ankylosing spondylitis vary from patient to patient, but they most commonly begin with the onset of low back pain and stiffness that is especially noticeable in the morning hours and after long periods of rest. (hss.edu)
Brucellar Spondylitis2
Tuberculous spondylitis4
- Pott disease, also known as tuberculous spondylitis, is a classic presentation of extrapulmonary tuberculosis (TB). (medscape.com)
- Daire A, Tuberculous spondylitis. (radiopaedia.org)
- These findings are consistent with Tuberculous spondylitis , which typically involves the vertebral bodies. (radiopaedia.org)
- Discrimination of tuberculous spondylitis from pyogenic spondylitis on MRI. (radiopaedia.org)
Psoriatic arthritis and ankylosing2
- A study reveals that axial psoriatic arthritis and ankylosing spondylitis with psoriasis are different diseases with different genetics, demographics, and disease expression. (pharmacytimes.com)
- To investigate whether IL17-inhibitors (IL17i) initiation in real life is associated with a higher risk of inflammatory bowel disease (IBD) in patients with psoriasis (PsO), psoriatic arthritis, and ankylosing spondylitis (PsA/AS). (medpagetoday.com)
Stiffness2
- The following yoga poses have been selected because they target areas of stiffness commonly encountered by those with ankylosing spondylitis. (everydayhealth.com)
- The most common symptom of ankylosing spondylitis is low back pain and/or neck pain, morning stiffness and limited motion that is improved by exercise and unrelieved by periods of rest. (hss.edu)
Cure for ankylosing1
- Although there is no cure for ankylosing spondylitis, your doctor will work with you to help manage the disease. (nih.gov)
Symptoms of ankylosing4
- What are the symptoms of ankylosing spondylitis? (hss.edu)
- HUMIRA is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults. (humira.com)
- Long-term analyses suggest Cosentyx may lead to higher responses than Humira in improving signs and symptoms of ankylosing spondylitis and psoriatic arthritis. (europeanpharmaceuticalreview.com)
- Cosentyx Phase III studies have consistently demonstrated significant improvements in the signs and symptoms of ankylosing spondylitis and psoriatic arthritis. (europeanpharmaceuticalreview.com)
Ankylosing spondylitis treated1
- Braun J, Baraliakos X, Listing J et al (2005) Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and entanercept. (springer.com)
Patients15
- This article presents the current concepts of correction of spinal deformity in ankylosing spondylitis (AS) patients. (nih.gov)
- Ankylosing spondylitis patients have back pain or hip pain. (wikipedia.org)
- When the data were analyzed over time, there was also an increase in joint swelling in both patients with axial PsA and patients with peripheral PsA, whereas patients with AS with or without psoriasis were more likely to have back pain and a higher BASMI, or Bath Ankylosing Spondylitis Metrology Index, a measure of AS disease severity. (pharmacytimes.com)
- From January 2002 to August 2015, 62 patients with Brucella-associated spondylitis were treated with comprehensive diagnosis based on epidemiological history, clinical manifestations, imaging findings, laboratory tests, and local biopsy. (scirp.org)
- Baines M, Ebringer A, Avakian H et al (1990) The use of enzyme immunoassay (EIA) and radiobinding assay to investigate the cross-reactivity of Klebsiella antigens and HLA-B27 in ankylosing spondylitis patients and healthy controls. (springer.com)
- We analyzed 47 hips (24 patients) with ankylosing spondylitis that underwent primary THA. (amrita.edu)
- Genomic DNA obtained from 262 persons (122 patients with ankylosing spondylitis and 140 healthy controls) was used in the study. (molvis.org)
- Human leukocyte antigen B27 (HLAB 27) positive patients in particular -mostly those in the subgroup with ankylosing spondylitis- are affected. (molvis.org)
- Fatigue and sleep problems are significant in patients with ankylosing spondylitis (AS). (jrheum.org)
- Determination of serum methylarginine levels by tandem mass spectrometric method in patients with ankylosing spondylitis. (physiciansweekly.com)
- Use this form to apply to continue PBS-subsidised treatment with a biological agent for adult patients with ankylosing spondylitis. (servicesaustralia.gov.au)
- This study examines the association between several aspects of social role participation and satisfaction with life (SWL) in patients with ankylosing spondylitis (AS) compared to population controls. (maastrichtuniversity.nl)
- Radiographs are the single most important imaging technique for the detection, diagnosis, and follow-up monitoring of patients with ankylosing spondylitis. (medscape.com)
- Drug use disorder increased the likelihood of in-hospital mortality more than 10-fold in patients with ankylosing spondylitis (AS), compared with patients who did not die while hospitalized. (medscape.com)
- 1987). Long Term Mortality After a Single Treatment Course with X-rays in Patients Treated for Ankylosing Spondylitis. (cdc.gov)
20231
- Cite this: CV Disease, Drug Abuse Big Contributors to Mortality in Ankylosing Spondylitis - Medscape - Sep 22, 2023. (medscape.com)
Inflammation9
- Spondylitis is an inflammation of the vertebrae. (wikipedia.org)
- A combination of spondylitis and inflammation of the intervertebral disc space is termed a spondylodiscitis. (wikipedia.org)
- Ankylosing spondylitis (AS) is a form of arthritis that's associated with long-term inflammation of the spinal joints, also called vertebrae. (healthline.com)
- Treatment for cervical spondylitis includes medication to control inflammation and your body's immune system. (nuffieldhealth.com)
- Where x-ray changes are not present but inflammation is visible on MRI or you have symptoms, this is called non-radiographic axial spondyloarthritis, and is sometimes considered an early form of ankylosing spondylitis. (arthritisireland.ie)
- Doctors will often prescribe Celecoxib to a patient who is suffering from pain or inflammation as a result of such diagnoses as arthritis, menstrual pain, as well as ankylosing spondylitis. (planetdrugsdirect.com)
- If there is a diagnosis of ankylosing spondylitis, a doctor is likely going to prescribe an NSAID such as Celecoxib to treat the inflammation and pain. (planetdrugsdirect.com)
- Ankylosing spondylitis is a distinct disease entity characterized by inflammation of multiple articular and para-articular structures, frequently resulting in bony ankylosis. (medscape.com)
- Spondylitis refers to inflammation of one or more vertebrae. (medscape.com)
Causes ankylosing1
- Doctors don't know exactly what causes ankylosing spondylitis. (msdmanuals.com)
Diagnose ankylosing3
- No single test can diagnose ankylosing spondylitis (AS), but a range of questions and techniques can help confirm or rule out a diagnosis. (medicalnewstoday.com)
- What tests can diagnose ankylosing spondylitis? (medicalnewstoday.com)
- Are there any special tests that are used to diagnose ankylosing spondylitis? (arthritisireland.ie)
Genetics1
- Genetics of ankylosing spondylitis--insights into pathogenesis. (ox.ac.uk)
Vertebral2
- In many cases, spondylitis involves one or more vertebral joints, as well, which itself is called spondylarthritis. (wikipedia.org)
- These complications commonly affect the axial skeleton, with vertebral spondylitis accounting for 35%-50% of all osteoarticular complications [4-6]. (who.int)
Sacroiliac2
- Ankylosing spondylitis is an inflammatory arthritis where the main symptom is back pain and changes can be seen to the sacroiliac joints on x-rays. (arthritisireland.ie)
- Ankylosing spondylitis has a predilection for the axial skeleton, affecting particularly the sacroiliac and spinal facet joints and the paravertebral soft tissues. (medscape.com)
Nonsteroidal Anti-1
- Ankylosing spondylitis treatment usually starts with physical therapy and nonsteroidal anti-inflammatory drugs (NSAIDs). (mayoclinic.org)
Posture1
- Harmful effects include increased oxygen consumption and pulmonary ventilation, difficulty in maintaining steady posture, changes in bone structure involving spondylitis deformations, intervertebral osteochondrosis, and calcification of the intervertebral discs and Schmorl's nodes. (cdc.gov)
Adalimumab1
- This guidance replaces NICE technology appraisal guidance on adalimumab, etanercept and infliximab for ankylosing spondylitis (TA143) and golimumab for the treatment of ankylosing spondylitis (TA233). (nice.org.uk)
Severe1
- If you have more severe ankylosing spondylitis, doctors may give you biologic medicines. (msdmanuals.com)
Cervical1
- How is cervical spondylitis treated? (nuffieldhealth.com)
Radiographic3
- Axial spondyloarthritis (axial SpA) is is an umbrella term for ankylosing spondylitis and non-radiographic axial spondyloarthritis. (arthritisireland.ie)
- [2] Radiographic axial spondyloarthritis is also known as ankylosing spondylitis (AS). (physio-pedia.com)
- The diagnosis may be reliably made if the typical radiographic features of ankylosing spondylitis are present. (medscape.com)
Diseases2
- Though many people with ankylosing spondylitis and related diseases respond well to traditional spondyloarthritis medications, such as NSAIDs and biologic medications, as well as exercise and physical therapy, others experience breakthrough pain even with appropriate treatment. (spondylitis.org)
- Ankylosing spondylitis is considered to be a chronic condition from the group of systemic inflammatory diseases of rheumatic pattern. (bvsalud.org)
Mayo Clinic1
- Ankylosing spondylitis, according to the Mayo Clinic, affects men more than it affects women. (planetdrugsdirect.com)
Commonly2
NSAIDs1
- Prescription NSAIDs approved by the Food and Drug Administration (FDA) for treating ankylosing spondylitis include naproxen (Naprosyn), sulindac, diclofenac, indomethacin (Indocin), and piroxicam (Feldene). (mayoclinic.org)
Diagnosing2
- Diagnosing ankylosing spondylitis usually involves a variety of tests. (medicalnewstoday.com)
- Diagnosing and treating ankylosing spondylitis may require a team of health care professionals. (nih.gov)
Enthesitis1
- Pain in AS can be caused by sacroiliitis , enthesitis, and spondylitis. (physio-pedia.com)
Treatment8
- Ankylosing spondylitis treatment is most successful when started before the disease causes irreversible damage to your joints. (mayoclinic.org)
- Secukinumab (Cosentyx) and ixekizumab (Taltz) are approved by the FDA for the treatment of ankylosing spondylitis. (mayoclinic.org)
- Upadacitinib (Rinvoq) and tofacitinib (Xeljanz) are approved by the FDA for the treatment of ankylosing spondylitis. (mayoclinic.org)
- ankylosing spondylitis ayurvedic treatment in. (viesearch.com)
- To explore senile brucellosis spondylitis clinical features and diagnostic criteria, in order to improve the diagnosis rate and evaluate the clinical effects of treatment strategies. (scirp.org)
- Thirty-four extracts from 13 South African plant species traditionally used for the treatment of inflam mation were investigated for their ability to control a microbial trigger for ankylosing spondylitis ( Klebsiella pneumoniae ). (springer.com)
- Can Exercise Support Treatment for Ankylosing Spondylitis? (creakyjoints.org)
- Sara's ACR poster "Exercise as a Supportive Treatment for my Ankylosing Spondylitis" describes how she has been able to steer clear of symptoms by maintaining a regular exercise regimen in addition to adhering to her treatment of a monthly biologic. (creakyjoints.org)
Affects1
- The National Institute for Health and Care Excellence (NICE) has recommended innovative new drug secukinumab for treating ankylosing spondylitis, a type of arthritis that mainly affects the back. (europeanpharmaceuticalreview.com)
Chronic3
- Ankylosing spondylitis causes chronic joint pain, usually starting in the back and buttocks. (medicalnewstoday.com)
- When people are first diagnosed with a chronic inflammatory disease like ankylosing spondylitis (AS), many questions and fears come up. (creakyjoints.org)
- Ankylosing spondylitis, represented in the radiograph below, usually is classified as a chronic and progressive form of seronegative arthritis. (medscape.com)
Inflammatory1
- As noted above, having this genetic marker does not by itself mean a person has ankylosing spondylitis or any other inflammatory condition. (hss.edu)
Sacroiliitis1
- Sacroiliitis occurs early in the course of ankylosing spondylitis and is regarded as a hallmark of the disease. (medscape.com)
Spinal1
- [8] Syndesmophytes are one of the main features of spinal structural damage in ankylosing spondylitis. (physio-pedia.com)
Incidence1
- Estimates of the incidence of spondylitis range from 9% to 31% [4,5]. (who.int)
Complication1
- While yoga is safe for most healthy individuals, some poses are better avoided by those with osteoporosis , a common complication of ankylosing spondylitis. (everydayhealth.com)
People7
- Here's a list of seven fun things to try for people with ankylosing spondylitis. (healthline.com)
- Most people with ankylosing spondylitis don't need surgery. (mayoclinic.org)
- Taking a deep breath is difficult for many people with ankylosing spondylitis. (everydayhealth.com)
- More than 90% of people with ankylosing spondylitis have a particular genetic marker called HLA-B27, which can be found on their white blood cells. (hss.edu)
- It is clear that some unidentified environmental trigger (and likely there is more than one type) plays a role in determining which people with this genetic marker end up developing ankylosing spondylitis. (hss.edu)
- Most people with ankylosing spondylitis develop some disabilities but can still lead normal lives. (msdmanuals.com)
- These have been used in people with arthritis as well as ankylosing spondylitis. (planetdrugsdirect.com)
Psoriasis1
- Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomitant psoriasis? (pharmacytimes.com)
Characteristic1
- The senile Brucellosis spondylitis has a characteristic performance. (scirp.org)
Genetic marker1
- As a result of our study, angiotensin converting enzyme gene I/D polymorphism DD genotype could be a genetic marker in ankylosing spondylitis in a Turkish study population. (molvis.org)