Spondylitis, Ankylosing: A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.Spondylitis: Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.HLA-B27 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.Sacroiliac Joint: The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.Spine: The spinal or vertebral column.Spondylarthritis: Inflammation of the joints of the SPINE, the intervertebral articulations.Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.Spondylarthropathies: Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.ArthritisIritis: Inflammation of the iris characterized by circumcorneal injection, aqueous flare, keratotic precipitates, and constricted and sluggish pupil along with discoloration of the iris.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Tuberculosis, Spinal: Osteitis or caries of the vertebrae, usually occurring as a complication of tuberculosis of the lungs.Arthritis, Reactive: An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.Arthritis, Psoriatic: A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Balneology: Therapy by various hot or warm baths in natural mineral waters, spas, or "cures". It includes not only bathing in, but also drinking the waters, but it does not include whirlpool baths (HYDROTHERAPY).Uveitis, Anterior: Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Kyphosis: Deformities of the SPINE characterized by an exaggerated convexity of the vertebral column. The forward bending of the thoracic region usually is more than 40 degrees. This deformity sometimes is called round back or hunchback.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Thoracic Vertebrae: A group of twelve VERTEBRAE connected to the ribs that support the upper trunk region.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Cervical Vertebrae: The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Osteitis: Inflammation of the bone.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Back Pain: Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.Pseudarthrosis: A pathologic entity characterized by deossification of a weight-bearing long bone, followed by bending and pathologic fracture, with inability to form normal BONY CALLUS leading to existence of the "false joint" that gives the condition its name. (Dorland, 27th ed)Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Spinal DiseasesTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Sacroiliitis: Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Klebsiella: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.Psoas Abscess: Abscess of the PSOAS MUSCLES resulting usually from disease of the lumbar vertebrae, with the pus descending into the muscle sheath. The infection is most commonly tuberculous or staphylococcal.

*  harryortho: Spinal Infection
spondylitis in children: The evolution. to current thought. Am J Orthop. 1996;25:342-348. ...
  http://harryortho.blogspot.com/2008/10/spinal-infection.html
*  Spondylitis Association of America - Ankylosing Spondylitis and Related Disease Information & Support
SAA is a non-profit organization and we were the first and remain the largest resource for people affected by spondylitis in ... Ankylosing spondylitis and spondyloarthritis symptoms, diagnosis, treatment, medication, educational materials, brochures. ... Axial spondyloarthritis and ankylosing spondylitis patient support, message boards, physician resources and more. ... Ankylosing spondylitis, spondyloarthritis and related disease information, education and support. ...
  https://www.spondylitis.org/
*  Ankylosing Spondylitis Pregnancy
Find out what to expect during pregnancy if you have ankylosing spondylitis. You'll learn how your arthritis will impact your ... Ankylosing Spondylitis and Pregnancy. Learn how ankylosing spondylitis will impact your pregnancy.. * ... If a C-section is a necessity - as it often is in women with ankylosing spondylitis - you may need to have general anesthesia. ... Having ankylosing spondylitis is unlikely to affect your baby; however, it can affect your baby's delivery. Spinal inflammation ...
  https://www.arthritis.org/living-with-arthritis/life-stages/pregnancy-family/pregnancy-and-ankylosing-spondylitis.php
*  About Spondylitis
SAA is a non-profit organization and we were the first and remain the largest resource for people affected by spondylitis in ... Ankylosing spondylitis and spondyloarthritis symptoms, diagnosis, treatment, medication, educational materials, brochures. ... Axial spondyloarthritis and ankylosing spondylitis patient support, message boards, physician resources and more. ... Ankylosing spondylitis, spondyloarthritis and related disease information, education and support. ...
  https://www.spondylitis.org/About-Spondylitis
*  Ankylosing Spondylitis
... and research to ensure a better life for all spondylitis patients. ... The Spondylitis Association of America is the only non-profit organization in the United States dedicating its resources to the ... active support of ankylosing spondylitis patients to bring about awareness, education, ... Overview of Ankylosing Spondylitis Ankylosing spondylitis (pronounced ank-kih-low-sing spon-dill-eye-tiss), or AS, is a form of ...
  https://www.spondylitis.org/Ankylosing-Spondylitis
*  Spondylitis Awareness Month<...
... and research to ensure a better life for all spondylitis patients. ... The Spondylitis Association of America is the only non-profit organization in the United States dedicating its resources to the ... active support of ankylosing spondylitis patients to bring about awareness, education, ... Remember, with spondylitis, what you don't know really can hurt you. So help shorten the long road to diagnosis by getting the ...
  https://www.spondylitis.org/About-Spondylitis/Spondylitis-Awareness-Month
*  Ankylosing spondylitis and other spondyloarthritis
Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes pain in the back, neck, and sometimes hips and heels ... ANKYLOSING SPONDYLITIS RISK FACTORS. Ankylosing spondylitis (AS) is two to three times more common in males than in females. It ... ANKYLOSING SPONDYLITIS SIGNS AND SYMPTOMS. The most common symptom of ankylosing spondylitis (AS) is pain in the lower back. ... ANKYLOSING SPONDYLITIS AND COMORBIDITIES. There is a possibility that patients with ankylosing spondylitis (AS) may have a ...
  https://www.uptodate.com/contents/ankylosing-spondylitis-and-other-spondyloarthritis-beyond-the-basics
*  Ankylosing Spondylitis | HealthLink BC
Discusses ankylosing spondylitis, a condition that causes pain, stiffness, and swelling in the spine. Covers causes and ... What is ankylosing spondylitis?. Ankylosing spondylitis (say "ang-kill-LOH-sing spawn-duh-LY-tus") is a long-term form of ... What causes ankylosing spondylitis?. The cause is unknown, but it may run in families. Most people with ankylosing spondylitis ... Mild or early ankylosing spondylitis. Ankylosing spondylitis usually starts with dull pain in the low back and back stiffness. ...
  https://www.healthlinkbc.ca/health-topics/tr4496
*  Ankylosing Spondylitis Clinical Research Trials | CenterWatch
Ankylosing Spondylitis Clinical Research Trial Listings in Musculoskeletal Rheumatology Orthopedics/Orthopedic Surgery on ... Ankylosing Spondylitis Clinical Trials. A listing of Ankylosing Spondylitis medical research trials actively recruiting patient ...
  http://www.centerwatch.com/clinical-trials/listings/condition/469/ankylosing-spondylitis/?phase=5
*  Treatment Options for Ankylosing Spondylitis | HealthCentral
Ankylosing Spondylitis and My New Wheelchair. Charis Hill. From Star Athlete to Ankylosing Spondylitis Patient Advocate. Pamela ... Ankylosing Spondylitis: The Prognosis. Judi Ebbert, PhD, MPH, RN. Arthritis: What Role Does Heredity Play?. Judi Ebbert, PhD, ... Ankylosing Spondylitis (AS): Medications Can Maximize Quality of Life. Judi Ebbert, PhD, MPH, RN , Feb 21, 2017 March 2, 2017 ... The Spondylitis Association of America offers comprehensive information and interactive mechanisms for messaging and support. ...
  http://www.healthcentral.com/slideshow/ankylosing-spondylitis-medications-can-maximize-quality-life?ic=recc
*  Take Control of Your Ankylosing Spondylitis Pain
Pilates and Yoga for Ankylosing Spondylitis. Because ankylosing spondylitis affects the joints, doing a variety of low-impact ... National Ankylosing Spondylitis Society, when exercising in water that's waist deep, you weigh half of what you weigh out of ... Eating for Ankylosing Spondylitis: Foods That Can Help Support Strong Bones. It's true that there's no special, miracle diet ... Eating for Ankylosing Spondylitis: Foods That Can Help Support Strong Bones. It's true that there's no special, miracle diet ...
  https://www.healthline.com/health/ankylosing-spondylitis/living-better/take-control
*  Neck Exercises for Spondylitis | LIVESTRONG.COM
If you suffer from spondylitis, you need a solid and consistent exercise program. You will benefit from exercise even if you ... Spondylitis in the Neck. The most common site of problem for people with ankylosing spondylitis is the sacroiliac joints, which ... There is no cure for ankylosing spondylitis, so it is very important for those with spondylitis to make their long-term ... spondylitis does not always start there. Spondylitis that begins in the neck could delay diagnosis. If started in the low back ...
  https://www.livestrong.com/article/323507-neck-exercises-for-spondylitis/
*  Fluoride Action Network | Fluoride & Spondylosis; Spondylitis
Fluorosis & Spondylosis/Spondylitis:. "Ankylosing spondylitis and osteofluorosis had a remarkable similarity in their clinical ... Fluoride & Spondylosis; Spondylitis. F.A.N. , May 2012 , By Michael Connett Among individuals with skeletal fluorosis, the ... Spondylitis, by contrast, is an inflammatory form of arthritis that causes inflammation in the joints between the vertebrae. ... Spondylitis is a rarer condition, affecting an estimated 129 out of 100,000 persons. Although research has repeatedly found ...
  https://fluoridealert.org/studies/skeletal_fluorosis10/
*  Frakturen der Halswirbelsäule bei Spondylitis ankylosans | SpringerLink
Patienten mit Spondylitis ankylosans (AS), die ein Wirbelsäulentrauma erleiden, haben ein... ... Boonen A, van der Linden SM (2006) The burden of ankylosing spondylitis. J Rheumatol Suppl 78:4-11PubMedGoogle Scholar ... Lukasiewicz AM, Bohl DD (2016) Spinal fracture in patients with ankylosing spondylitis. Spine 41(3):191-196CrossRefPubMedGoogle ... Fast A, Parikh S, Marin EL (1986) Spine fractures in ankylosing spondylitis. Arch Phys Med Rehabil 67(9):595-597PubMedGoogle ...
  https://link.springer.com/article/10.1007/s10039-016-0217-7
*  Spondylitis | Laser Spine Institute
Home » Spine Articles » Spondylitis Spondylitis. Four Exercises to Do During Your Spondylitis Surgery Recovery Many people ... 7 Tips To Ease Spondylitis Pain During Long Car Rides Spondylitis, also known as ankylosing spondylitis, is a type of arthritis ... Spondylitis Causes and Treatment It can be confusing for patients who are researching the causes and treatment of spondylitis ... Spondylitis Causes and Symptoms Spondylitis is an inflammatory disease that affects the spine. This can be a very debilitating ...
  https://www.laserspineinstitute.com/articles/spondylitis/
*  Summer Spondylitis Association of America
Each individual affected by spondylitis has their own unique story. We at SAA believe that each and every story can be a source ... Spondylitis Association of America. 16360 Roscoe Blvd. Ste. 100. Van Nuys, CA 91406 ... We'd love your story as well! Send it to us at elin@spondylitis.org ... I think there is a strong possibility you might have ankylosing spondylitis. Please see your GP and request they get you ...
  https://www.spondylitis.org/Your-Stories/summer
*  NSAIDs - Ankylosing Spondylitis - MedBroadcast.com
Ankylosing Spondylitis: NSAIDs. Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce joint pain and inflammation. They do not ...
  http://www.medbroadcast.com/channel/ankylosing-spondylitis/treating-as---taking-control/nsaids
*  Best Doctors for Ankylosing Spondylitis - Chronic Pain | HealthCentral
Find out more about which specialists are able to make a diagnosis of ankylosing spondylitis (AS) and which can assist by ... article Ankylosing Spondylitis and My New Wheelchair slideshow Treatment Options for Ankylosing Spondylitis article Ankylosing ... Ankylosing Spondylitis, Uveitis and Eye Health. Malaika Hill. From Star Athlete to Ankylosing Spondylitis Patient Advocate. ... Everyday Life with Ankylosing Spondylitis. Pamela Kaufman. Bridging the Gap: Living with AS. Arthritis: What Role Does Heredity ...
  https://www.healthcentral.com/article/what-medical-specialists-diagnose-and-treat-ankylosing-spondylitis
*  Special Diet for Ankylosis Spondylitis | LIVESTRONG.COM
Ankylosing spondylitis, or AS, is a type of arthritis that most often affects the spine and causes inflammation and ... The Spondylitis Association of America, or SAA, says that the cause of AS is unknown but there seems to be a genetic connection ... Ankylosing spondylitis, or AS, is a type of arthritis that most often affects the spine and causes inflammation and ... Special Diet for Ankylosis Spondylitis by MEGAN ASHTON Last Updated: Jul 18, 2017. ...
  https://www.livestrong.com/article/357201-special-diet-for-ankylosis-spondylitis/
*  HLA-B27 and risk of ankylosing spondylitis. | The BMJ
HLA-B27 and risk of ankylosing spondylitis. Br Med J 1978; 2 :650 ... HLA-B27 and risk of ankylosing spondylitis.. Br Med J 1978; 2 doi: https://doi.org/10.1136/bmj.2.6138.650 (Published 02 ...
  http://www.bmj.com/content/2/6138/650
*  Ankylosing Spondylitis | PeaceHealth
Discusses ankylosing spondylitis, a condition that causes pain, stiffness, and swelling in the spine. Covers causes and ... Ankylosing Spondylitis. Skip to the navigation Topic Overview. What is ankylosing spondylitis?. Ankylosing spondylitis (say " ... What causes ankylosing spondylitis?. The cause is unknown, but it may run in families. Most people with ankylosing spondylitis ... Mild or early ankylosing spondylitis. Ankylosing spondylitis usually starts with dull pain in the low back and back stiffness. ...
  https://www.peacehealth.org/medical-topics/content/mini/tr4496.html
*  Face 0111 Spondylitis Association of America
The Faces of Ankylosing Spondylitis Faces of Ankylosing Spondylitis is a website dedicated entirely to the stories of those ... I am worried spondylitis has affected the joints in my rib cage. If this is indeed true that means my chest is seizing up and ... I wanted to honor those who have Ankylosing Spondylitis, who I admire and respect." -Cookie Hopper. Creator of Faces of AS, SAA ... It was ANKYLOSING SPONDYLITIS. Now, normally people would be devastated upon hearing they have a lifelong debilitating disease ...
  https://www.spondylitis.org/The-Faces-of-Ankylosing-Spondylitis/face-0111
*  Face 0026 Spondylitis Association of America
The Faces of Ankylosing Spondylitis Faces of Ankylosing Spondylitis is a website dedicated entirely to the stories of those ... I wanted to honor those who have Ankylosing Spondylitis, who I admire and respect." -Cookie Hopper. Creator of Faces of AS, SAA ... As many others with ankylosing spondylitis, I've become passionate about helping raise awareness. It's my hope (our hope) that ... In the span of a year I was diagnosed with ankylosing spondylitis, psoriatic arthritis, mixed connective tissue disease, ...
  https://www.spondylitis.org/The-Faces-of-Ankylosing-Spondylitis/face-0026
*  Face 0126 Spondylitis Association of America
The Faces of Ankylosing Spondylitis Faces of Ankylosing Spondylitis is a website dedicated entirely to the stories of those ... What many may not know about me is that I have an autoimmune disease known as Ankylosing Spondylitis. I was born with the gene ... I wanted to honor those who have Ankylosing Spondylitis, who I admire and respect." -Cookie Hopper. Creator of Faces of AS, SAA ... Spondylitis Association of America. 16360 Roscoe Blvd. Ste. 100. Van Nuys, CA 91406 ...
  https://www.spondylitis.org/The-Faces-of-Ankylosing-Spondylitis/face-0126
*  Diet and Nutrition for Ankylosing Spondylitis
For those suffering from Ankylosing Spondylitis, having a healthy diet can help immensely, not only in relieving the symptoms, ... Diet and Nutrition for Ankylosing Spondylitis. Healthy eating is an important part in taking control, not only of your health ... Ankylosing Spondylitis is common in Canada, USA, Europe, and Australia since most of the people consume meat and milk as part ... Ankylosing spondylitis is a deforming and painful condition. Early in the disease, it can be misdiagnosed as fibromyalgia, or ...
  http://www.prohealth.com/fibromyalgia/library/showArticle.cfm?fontSize=medium&libid=18537

SpondylitisHLA-B38: HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.Sacroiliac joint dysfunction: Sacroiliac joint dysfunction, also called sacroiliac joint disorder, sacroiliac joint disease, sacroiliac joint syndrome or sacroiliac syndrome, or "sacroilliac dysfunction and instability", generally refers to pain in the sacroiliac joint region that is caused by abnormal motion in the sacroiliac joint, either too much motion or too little motion. It typically results in inflammation of the sacroiliac joint, and can be debilitating.AnakinraAutomated analyser: An automated analyser is a medical laboratory instrument designed to measure different chemicals and other characteristics in a number of biological samples quickly, with minimal human assistance.Arthritis Research UKRed eye (medicine)Reactive arthritisDactylitis: Dactylitis or sausage digit is inflammation of an entire digit (a finger or toe), and can be painful.Annals of the Rheumatic Diseases: The Annals of the Rheumatic Diseases is a peer-reviewed medical journal. It is co-owned by the BMJ Group and the European League Against Rheumatism and covers all aspects of rheumatology, including musculoskeletal conditions, arthritis, and connective tissue diseases.Balneotherapy: Balneotherapy ( "bath") is the treatment of disease by bathing, usually practiced at spas. While it is considered distinct from hydrotherapy, there are some overlaps in practice and in underlying principles.UveitisACR score for rheumatoid arthritis: ACR score is a scale to measure change in rheumatoid arthritis symptoms. It is named after the American College of Rheumatology.Clay-shoveler fracture: Clay-shoveler's fracture is a stable fracture through the spinous process of a vertebra occurring at any of the lower cervical or upper thoracic vertebrae, classically at C6 or C7. In Australia in the 1930s, men digging deep ditches tossed clay 10 to 15 feet above their heads using long handled shovels.HLA B7-DR15-DQ6Cervical fractureCD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.Osteitis pubisSulfasalazineCelecoxibPseudarthrosisTACI-CRD2 protein domain: In molecular biology, this protein domain, TACI-CRD2 represents the second cysteine-rich protein domain found in the TACI family of proteins. Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF.Cervical spine disorder: Cervical Spine Disorders are illnesses that are relatively detrimental to ones physical health. These ailments exist in the cervical spine which is made up of the upper first seven vertebrae, encasing and shielding the Spinal cord.Monoclonal antibody therapyKlebsiella terrigena: Klebsiella terrigena is a Gram-negative bacterial species of the genus Klebsiella. It has primarily been isolated from soil and water samples, but rarely from humans.Psoas muscle abscess

(1/182) Nuclear factor-kappa B activity in T cells from patients with rheumatic diseases: a preliminary report.

OBJECTIVE: The NF-kappa B/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level. The aim of this study was to determine whether distinctive patterns of NF-kappa B activation are seen in different forms of joint disease. METHODS: The DNA binding activity of these nucleoproteins was examined in purified synovial and peripheral T cells from patients with various chronic rheumatic diseases (12: four with rheumatoid arthritis; five with spondyloarthropathies; and three with osteoarthritis). RESULTS: Electrophoretic mobility shift assays disclosed two specific complexes bound to a NF-kappa B specific 32P-labelled oligonucleotide in nucleoproteins extracted from purified T cells isolated from synovial fluid and peripheral blood of patients with rheumatoid arthritis. The complexes consisted of p50/p50 homodimers and p50/p65 heterodimers. Increased NF-kappa B binding to DNA in synovial T cells was observed relative to peripheral T cells. In non-rheumatoid arthritis, binding of NF-kappa B in synovial T cells was exclusively mediated by p50/p50 homodimers. CONCLUSION: Overall, the results suggest that NF-kappa B may play a central part in the activation of infiltrating T cells in chronic rheumatoid arthritis. The activation of this nuclear factor is qualitatively different in rheumatoid synovial T cells to that in other forms of non-rheumatoid arthritis (for example, osteoarthritis, spondyloarthropathies).  (+info)

(2/182) Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases.

The MR imaging findings of fungal spinal osteomyelitis in three recipients of organ transplants showed hypointensity of the vertebral bodies on T1-weighted sequences in all cases. Signal changes and enhancement extended into the posterior elements in two cases. Multiple-level disease was present in two cases (with a total of five intervertebral disks involved in three cases). All cases lacked hyperintensity within the disks on T2-weighted images. In addition, the intranuclear cleft was preserved in four of five affected disks at initial MR imaging. MR features in Candida and Aspergillus spondylitis that are distinct from pyogenic osteomyelitis include absence of disk hyperintensity and preservation of the intranuclear cleft on T2-weighted images. Prompt recognition of these findings may avoid delay in establishing a diagnosis and instituting treatment of opportunistic osteomyelitis in the immunocompromised patient.  (+info)

(3/182) Rheumatic disease and the Australian aborigine.

OBJECTIVE: To document the frequency and disease phenotype of various rheumatic diseases in the Australian Aborigine. METHODS: A comprehensive review was performed of the archaeological, ethnohistorical, and contemporary literature relating to rheumatic diseases in these indigenous people. RESULTS: No evidence was found to suggest that rheumatoid arthritis (RA), ankylosing spondylitis (AS), or gout occurred in Aborigines before or during the early stages of white settlement of Australia. Part of the explanation for the absence of these disorders in this indigenous group may relate to the scarcity of predisposing genetic elements, for example, shared rheumatoid epitope for RA, B27 antigen for AS. In contrast, osteoarthritis appeared to be common particularly involving the temporomandibular joint, right elbow and knees and, most probably, was related to excessive joint loading in their hunter gatherer lifestyle. Since white settlement, high frequency rates for rheumatic fever, systemic lupus erythematosus, and pyogenic arthritis have been observed and there are now scanty reports of the emergence of RA and gout in these original Australians. CONCLUSION: The occurrence and phenotype of various rheumatic disorders in Australian Aborigines is distinctive but with recent changes in diet, lifestyle, and continuing genetic admixture may be undergoing change. An examination of rheumatic diseases in Australian Aborigines and its changing phenotype may lead to a greater understanding of the aetiopathogenesis of these disorders.  (+info)

(4/182) Studying patients with inflammatory back pain and arthritis of the lower limbs clinically and by magnetic resonance imaging: many, but not all patients with sacroiliitis have spondyloarthropathy.

OBJECTIVE: Clinical and magnetic resonance imaging (MRI) data of 170 consecutive patients with inflammatory back pain (IBP) and/or oligoarthritis of the lower limbs were evaluated in a retrospective study. The aim was to determine the frequency of sacroiliitis and spondyloarthropathy (SpA) in this population, and to assess the significance of HLA B27 measurements for diagnosis in early disease. METHODS: Pelvic X-rays were performed in all IBP patients and dynamic MRI of the sacroiliac joints in patients with IBP who had indefinite results on sacroiliac X-rays (n = 32). RESULTS: European Spondyloarthropathy Study Group criteria for SpA were fulfilled by 106/170 patients (62.4%); eight additional patients had symptoms suggestive of SpA (4.7%). The most frequent SpA subset was undifferentiated SpA (uSpA), diagnosed in 46/106 patients (43.4%). Sacroiliitis was detected by MRI in 21/32 patients with IBP and unclear X-rays (65.6%). Of those, 14 were diagnosed as SpA and seven females with moderate unilateral sacroiliitis, but no features of SpA, also not on follow-up (at least 1 yr), were classified as undifferentiated sacroiliitis (US). Ten of the 14 SpA (71.4%) and none of the seven US patients were HLA B27 positive. CONCLUSION: HLA B27 positivity in IBP patients with MRI-proven sacroiliitis positively predicts SpA. uSpA is a frequent SpA subset. There are HLA B27-negative non-SpA patients with moderate unilateral sacroiliitis whom we propose to be classified as US.  (+info)

(5/182) Increased Ed-B fibronectin plasma levels in spondyloarthropathies: comparison with rheumatoid arthritis patients and a healthy population.

OBJECTIVE: To determine, for the first time, plasma levels of general fibronectin (Fn) and two spliced isoforms, Ed-A and Ed-B, in patients with spondyloarthropathy (SpA) in comparison with rheumatoid arthritis (RA) patients and healthy volunteers (HV). METHODS: Plasmas (EDTA) as well as clinical data, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were collected in two groups of 10 patients fulfilling the European Spondylarthropathy Study Group criteria for SpA or the 1987 American College of Rheumatology criteria for RA. Plasmas of 21 blood donors served as controls. Plasma levels of Fns were determined by using an in-house immunocapture ELISA, using monoclonal antibodies (MAbs) against general Fn and its isoforms. RESULTS: Total Fn plasma levels were significantly higher in the SpA group (mean+/-S.D.=1387+/-569 mg/l) than in the RA group (684+/-196 mg/l; P=0.02) and in HV (303+/-211 mg/l; P<0.0001). Ed-A Fn levels appeared higher in SpA (23+/-10.4 mg/l) and RA (32.5+/-16.5 mg/l) groups than in the HV group (2.8+/-0.9 mg/l; P=0.0003 and P<0.0001, respectively), without a significant difference between SpA and RA groups. Ed-B Fn levels were higher in SpA (6.9+/-2.1 mg/l) than in RA (3.2+/-1.9 mg/l; P=0. 02) and HV (1.1+/-0.8 mg/l; P=0.0003) groups. No significant correlation was observed in SpA patients between each Fn level and clinical activity, ESR or CRP levels. CONCLUSIONS: This study showed an increase in plasma levels of Fn and Ed-B Fn in SpA patients compared with RA patients and HV, which could not be attributed solely to systemic inflammation. It may be hypothesized that Ed-A and Ed-B Fn might reflect local turnover in inflamed tissues, and that Ed-B Fn might be particularly involved in the musculoskeletal inflammatory process of SpA.  (+info)

(6/182) Brucellar spondylitis: review of 35 cases and literature survey.

Thirty-five patients aged 14-74 years (average, 54 years) who had brucellar spondylitis were treated between January 1991 and December 1997. The time from onset of symptoms to diagnosis of spondylitis ranged from 1 week to 8 months (median, 9 weeks). Back or neck pain (100% of patients), fever (66%), and constitutional symptoms (57%) were the most common symptoms. Cultures of blood specimens from 26 patients (74%) were positive for Brucella melitensis. The duration of antimicrobial therapy (median, 120 days; range, 45-535 days) varied according to clinical response and the presence of epidural and paravertebral masses. One of the 35 patients underwent surgical treatment of a spinal epidural abscess. Therapy failed for 9 patients (26%; 95% confidence interval [CI], 12%-43%), and 5 (14%; 95% CI, 5%-30%) had a relapse. There were no deaths or severe sequelae in this study. Brucellar spondylitis causes considerable suffering and absenteeism from work, but long-term clinical responses are favorable.  (+info)

(7/182) Misfolding of HLA-B27 as a result of its B pocket suggests a novel mechanism for its role in susceptibility to spondyloarthropathies.

The MHC class I protein HLA-B27 is strongly associated with susceptibility to spondyloarthropathies and can cause arthritis when expressed in rats and mice, implying a direct role in disease pathogenesis. A prominent hypothesis to explain this role suggests that the unique peptide binding specificity of HLA-B27 confers an ability to present arthritogenic peptides. The B pocket, a region of the peptide binding groove that is an important determinant of allele-specific peptide binding, is thought to be critical for arthritogenicity. However, this hypothesis remains unproven. We show that in addition to its role in peptide selection, the B pocket causes a portion of the pool of assembling HLA-B27 heavy chains in the endoplasmic reticulum to misfold, resulting in their degradation in the cytosol. The misfolding phenotype is corrected by replacing the HLA-B27 B pocket with one from HLA-A2. Our results suggest an alternative to the arthritogenic peptide hypothesis. Misfolding and its consequences, rather than allele-specific peptide presentation, may underlie the strong link between the HLA-B27 B pocket and susceptibility to spondyloarthropathies.  (+info)

(8/182) Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long term.

OBJECTIVE: To retrospectively assess, with a sufficiently long followup (mean 11.6 years; median 9 years), the long-term outcome of chronic recurrent multifocal osteitis (CRMO), a multifocal, inflammatory bone disease. METHODS: Patients included were 8 children/adolescents and 7 adults with no family history of rheumatic disease who had been diagnosed as having CRMO between 1979 and 1995. Ten patients had undergone at least 1 bone biopsy of the lesions, with histologic examination and multiple cultures. In 1996, in addition to an in-depth interview, 12 patients underwent an extensive physical examination, laboratory evaluation, HLA-A, B, C, and DR typing, bone radiography and scintigraphy, and computed tomography scan of the sternoclavicular and sacroiliac joints. RESULTS: Remission was observed in 3 patients. The other 12 patients developed various associations of vertebral (n = 10), sacroiliac (n = 6), anterior thoracic (n = 7), peripheral articular (n = 2), enthesopathic (n = 4), or dermatologic (palmoplantar pustulosis in 3 cases and psoriasis in 2) involvements. Spine involvement was the most common and occurred the earliest (median time to appearance after the onset of osteitis 5.63 years). Clinical sacroiliitis was always unilateral. No patients carried the HLA-B27 haplotype. CRMO responded well to nonsteroidal antiinflammatory drugs. Twelve patients met the European Spondylarthropathy Study Group criteria for spondylarthopathy. CONCLUSION: After 10 years, CRMO had usually evolved to spondylarthropathy, but with certain features not usually seen in the latter: predominantly, unilateral sacroiliitis, no familial form, and no link with HLA-B27.  (+info)




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  • progression
  • Your recommendations are based on the communication between your physician and physiotherapist, so make sure your physiotherapist understands spondylitis and the progression of your condition. (livestrong.com)