3-(p-Fluorophenyl)-alanine.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.
An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).
An independent administrative agency concerned with maintaining competitive free enterprise by prohibiting unfair methods of competition and unfair deceptive acts or practices.
Those federal and state laws, and their enforcement, that protect trade and commerce from unlawful restraints and monopolies or unfair business practices.
Viscous materials composed of complex, high-molecular-weight compounds derived from the distillation of petroleum or the destructive distillation of wood or coal. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
Decisions made by the United States Supreme Court.
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Special Administrative Region of the People's Republic of China since December 20, 1999 with its own constitution. The island of Macau and adjacent islands are located off the southeast coast of China.

Design and synthesis of para-fluorophenylalanine amide derivatives as thrombin receptor antagonists. (1/33)

An antagonist specific for the thrombin receptor is expected to be a remedy for thrombosis. Structure-activity studies of thrombin receptor-tethered ligand SFLLRNP have revealed the importance of the Phe-2-phenyl group in receptor recognition and the replacement of the Phe-2 by para-fluorophenylalanine [(p-F)Phe] was found to enhance its activity [Nose, T. et al. (1993) Biochem. Biophys. Res. Commun. 193, 694-699]. In order to obtain a small sized antagonist, a series of (p-F)Phe derivatives was designed and synthesized novel structural elements essential for receptor interactions being introduced at both the N and C-termini. beta-Mercaptopropionyl (betaMp) or its derivative activated by S-3-nitro-2-pyridinesulphenyl (Npys) was introduced at the N-terminus, and phenylmethyl amines were coupled to the C-terminus. All compounds were inactive when assayed for human platelet aggregation, indicating that they are not agonists. beta-Mercaptopropionyl derivatives were also inactive as antagonists. However, Npys-containing analogs were found to inhibit the agonist activity of SFLLRNP. In particular, SNpys-betaMp-(p-F)Phe-NH-R [R = -CH(C6H5)2 and -CH2-CH-(C6H5)2] potently suppressed platelet aggregation. The results suggested that (p-F)Phe can be used as a structural core to construct an effective antagonist conformation.  (+info)

Altered alpha subunits in phenylalanyl-tRNA synthetases from p-fluorophenylalanine-resistant strains of Escherichis coli. (2/33)

Three different phenylalanyl-tRNA synthetases have been purified to near homogeneity, one from a wild-type strain of Escherichia coli and the others from two independently isolated p-fluorophenyalanine-resistant strains. The mutant enzymes were not able to use p-fluorophenylalanine as a substrate for activation and attachment to tRNA. They proved to be indistinguishable from the wild-type enzyme by several electrophoretic and immunological criteria. The alpha and beta subunits of all three enzymes have been prepared by a method described in this paper. The isolated subunits per se did not reveal any significant enzyme activity, but combined they were able to form active phenylalanyl tRNA synthetase after a defined reconstitution process. Mixed reconstitution experiments between wild-type and mutant subunits indicate that the mutant alpha subunit is responsible for p-fluorophenylalanine resistance and therefore seems to carry the phenylalanine-binding site or to participate in its formation.  (+info)

Genetical and biochemical aspects of resistance to p-fluorophenylalanine in Saccharomyces cerevisiae. (3/33)

Growth of haploid yeast strains was inhibited by the phenylalanine (PA) analogue DL-p-fluorophenylalanine (FPA) in yeast extract media containing 0-2 mg PA/ml. Most strains had a maximum FPA tolerance of about 0-25 mg/ml when glycerol was the carbon source and 0-5 mg/ml in in glucose medium. Spontaneous FPA-resistant mutants isolated on glucose medium showed little or no increase in FPA tolerance over that of the parent when metabolizing glycerol. Resistance was controlled by a different nuclear gene in each of four mutants analysed. In a proportion of the mutants the amount of FPA incorporated into cellular proteins in competition with PA was less than into the proteins of sensitive parental cells, whether glucose or glycerol was used as carbon source. This suggests that the mutational change allowed the cytoplasmic system to descriminate against the analogue without affecting its incorporation into mitochondrially-synthesized proteins. Although attempts to measure the latter were not made, the observed decrease in respiratory activity of cells grown in the presence of FPA suggests such incorporation. In other mutants showing resistance to FPA in glucose medium, the amount of FPA incorporated into cellular proteins varied with the carbon source, less analogue being incorporated in glucose medium than in glycerol medium.  (+info)

Fluorescence and 19F NMR evidence that phenylalanine, 3-L-fluorophenylalanine and 4-L-fluorophenylalanine bind to the L-leucine specific receptor of Escherichia coli. (4/33)

The binding capacity of the L-leucine receptor from Escherichia coli was measured with L-phenylalanine and 4-fluoro-L-phenylalanine as substrates by fluorescence. The apparent dissociation constants (KD) for L-leucine, L-phenylalanine, and 4-fluoro-L-phenylalanine are 0.40, 0.18, and 0.26 respectively. 19F NMR data show protein-induced shifts for the 4-fluoro-L-phenylalanine peak and 3-fluoro-L-phenylalanine when receptor is present. Evidence points to the binding of only the L-isomers of these fluorine analogs.  (+info)

Analysis of the time of utilization of proteins for the initiation and completion of division in synchronized Tetrahymena pyriformis. (5/33)

We exposed division-synchronized Tetrahymena pyriformis to pulse treatments with the structural amino acid analogue p-fluorophenylalanine. We related the timing of the treatments to the delays in onset or completion of division, or both. The results enable us to distinguish between early and late phases in cell division in which the cells bring into action proteins which contribute to initiate and complete division, respectively. Normally, these events are separated by 25-30 min.  (+info)

Construction of a Bacillus subtilis (natto) with high productivity of vitamin K2 (menaquinone-7) by analog resistance. (6/33)

To invent a functional natto promoting bone formation, the construction of a strain with high productivity of vitamin K2 (menaquinone-7: MK-7), which is important in the carboxylation of a kind of bone protein participating in bone formation, osteocalcin, was investigated. To screen for a strain appropriate to making natto (a Japanese traditional fermented soybean food) with high productivity of MK-7, a combination of analog resistance to the compounds on the biosynthetic pathway of menaquinones with mutation was done. Consequently, strain OUV23481, with 2-fold higher productivity (1,719 microg/100 g natto) of MK-7 than that of a commercial strain, was constructed as a mutant with analog resistance to 1-hydroxy-2-naphthoic acid (HNA), p-fluoro-D,L-phenylalanine (pFP), m-fluoro-D,L-phenylalanine (mFP), and beta-2-thienylalanine (betaTA). This strain was classified as Bacillus subtilis (natto). The natto made using this strain was evaluated to have a good quality as natto in all the viewpoints of appearance, flavor, taste, texture, and stringiness.  (+info)

Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach. (7/33)

Striatal-to-occipital ratio (SOR) and influx constant K(i)(occ) are commonly used as analytic parameters in L-3,4-dihydroxy-6-(18)F-fluorophenylalanine (FDOPA) PET studies. Both have been shown to be useful in discriminating Parkinson's disease (PD) patients from healthy subjects. We evaluated the relative performance of SOR and influx constant (K(i)(occ)) in the clinical assessment of nigrostriatal dopaminergic function in PD. METHODS: Twenty-one parkinsonian patients (Hoehn and Yahr scale I-IV; mean age +/- SD, 56 +/- 9.2 y) and 11 healthy subjects (mean age, 60 +/- 16 y) underwent 3-dimensional dynamic FDOPA scanning from 0 to 100 min. After spatial realignment, PET images at each frame were integrated by summing 4 central striatal slices, and time-activity curves (TACs) were generated after placing a standard set of elliptic regions of interest over striatal and occipital structures. SOR and K(i)(occ) values for each subject were then computed from TACs at different times using an input function from the occipital cortex. RESULTS: Both SOR and K(i)(occ) showed significant bilateral decreases in striatal dopamine uptake in the PD group compared with the control group. SOR values estimated for 10-min frames between 65 and 95 min are statistically equivalent in group discrimination. In addition, SOR values in the caudate and putamen correlated strongly with K(i)(occ), especially toward the end of the scanning epoch. Both parameters correlated significantly and comparably with Unified Parkinson's Disease Rating Scale motor scores. CONCLUSION: These results suggest that SOR determined from a single 10-min scan at 95 min is as accurate as K(i)(occ) in separating PD patients from healthy subjects and in predicting clinical measures of disease severity.  (+info)

Anacystis nidulans mutants resistant to aromatic amino acid analogues. (8/33)

Three classes of mutants of Anacystis nidulans were selected on the basis of resistance to fluorophenylalanine and 2-amino-3-phenylbutanoic acid. The most frequent type exhibited DAHP synthetase (7-phospho-2-keto-3-deoxy-D-arabino-heptonate-D-erythrose-4-phosphate-lyase [pyruvate phosphorylating], EC 4.1.2.15) activity identical to that of the parental strain. The second type was characterized by extremely low levels of the activity. The third type had a DAHP synthetase showing decreased sensitivity to inhibition by L-tyrosine. The enzyme was purified 140-fold from wild-type and feedback-insensitive strains, and the kinetics of the reaction was examined. The activity of the wild-type enzyme was inhibited 75% in the presence of 2.0 X 10-3 M tyrosine, and the altered enzyme was inhibited 10%. The following apparent constants were obtained from kinetic studies with partially purified wild-type enzyme: S0.5 for D-erythrose-4-phophate equal to 7.1 X 10-4 M; S0.5 for phosphoenolpyruvate equal to 1.4 X 10-4 M. Inhibition by tyrosine was mixed with respect to binding of both D-erythrose-4-phosphate and phosphoenolpyruvate. In addition, tyrosine promoted cooperative interactions in the binding of phosphoenolpyruvate. For the altered enzyme the following apparent constants were obtained: S0.5 for D-erythrose-4-phosphate equal to 7.1 X 10-4 M; S0.5 for phosphoenolpyruvate equal to 2.9 X 10-4 M. Inhibition by tyrosine was mixed with respect to D-erythrose-4-phosphate and competitive with respect to phosphoenolpyruvate. Tyrosine did not promote cooperative effects in the binding of phosphoenolpyruvate to the altered enzyme.  (+info)

P-Fluorophenylalanine (p-FPA) is not a medical term, but a chemical compound used in research and medical fields. It's a type of amino acid that is used as a building block for proteins, similar to the naturally occurring amino acid phenylalanine. However, p-FPA has a fluorine atom attached to its para position (one of the possible positions on the phenyl ring).

This compound can be used in various research applications, including the study of protein synthesis and enzyme function. It's also been explored as a potential therapeutic agent for certain medical conditions, such as cancer and neurological disorders. However, more research is needed to establish its safety and efficacy for these uses.

Fluorine is not a medical term itself, but it is a chemical element that is often discussed in the context of dental health. Here's a brief scientific/chemical definition:

Fluorine is a chemical element with the symbol F and atomic number 9. It is the most reactive and electronegative of all elements. Fluorine is never found in its free state in nature, but it is abundant in minerals such as fluorspar (calcium fluoride).

In dental health, fluoride, which is a compound containing fluorine, is used to help prevent tooth decay. It can be found in many water supplies, some foods, and various dental products like toothpaste and mouthwash. Fluoride works by strengthening the enamel on teeth, making them more resistant to acid attacks that can lead to cavities.

Phenylalanine is an essential amino acid, meaning it cannot be produced by the human body and must be obtained through diet or supplementation. It's one of the building blocks of proteins and is necessary for the production of various molecules in the body, such as neurotransmitters (chemical messengers in the brain).

Phenylalanine has two forms: L-phenylalanine and D-phenylalanine. L-phenylalanine is the form found in proteins and is used by the body for protein synthesis, while D-phenylalanine has limited use in humans and is not involved in protein synthesis.

Individuals with a rare genetic disorder called phenylketonuria (PKU) must follow a low-phenylalanine diet or take special medical foods because they are unable to metabolize phenylalanine properly, leading to its buildup in the body and potential neurological damage.

Paper chromatography is a type of chromatography technique that involves the separation and analysis of mixtures based on their components' ability to migrate differently upon capillary action on a paper medium. This simple and cost-effective method utilizes a paper, typically made of cellulose, as the stationary phase. The sample mixture is applied as a small spot near one end of the paper, and then the other end is dipped into a developing solvent or a mixture of solvents (mobile phase) in a shallow container.

As the mobile phase moves up the paper by capillary action, components within the sample mixture separate based on their partition coefficients between the stationary and mobile phases. The partition coefficient describes how much a component prefers to be in either the stationary or mobile phase. Components with higher partition coefficients in the mobile phase will move faster and further than those with lower partition coefficients.

Once separation is complete, the paper is dried and can be visualized under ultraviolet light or by using chemical reagents specific for the components of interest. The distance each component travels from the origin (point of application) and its corresponding solvent front position are measured, allowing for the calculation of Rf values (retardation factors). Rf is a dimensionless quantity calculated as the ratio of the distance traveled by the component to the distance traveled by the solvent front.

Rf = (distance traveled by component) / (distance traveled by solvent front)

Paper chromatography has been widely used in various applications, such as:

1. Identification and purity analysis of chemical compounds in pharmaceuticals, forensics, and research laboratories.
2. Separation and detection of amino acids, sugars, and other biomolecules in biological samples.
3. Educational purposes to demonstrate the principles of chromatography and separation techniques.

Despite its limitations, such as lower resolution compared to high-performance liquid chromatography (HPLC) and less compatibility with volatile or nonpolar compounds, paper chromatography remains a valuable tool for quick, qualitative analysis in various fields.

The Federal Trade Commission (FTC) is not a medical organization or agency, but rather it is a consumer protection agency in the United States government. The FTC is responsible for protecting consumers and promoting competition by preventing anticompetitive, deceptive, and unfair business practices. While the FTC does not provide medical definitions, it may be involved in investigating and taking enforcement actions related to false or misleading health claims made by businesses.

Antitrust laws are a set of legal regulations that aim to promote competition and prevent monopolies in markets. These laws prohibit businesses from engaging in restrictive practices designed to reduce competition, such as price-fixing, bid-rigging, and market allocation schemes. Antitrust laws also discourage mergers and acquisitions that may substantially lessen competition or create monopolies. The ultimate goal of antitrust laws is to protect consumers from unfair or deceptive trade practices, promote economic efficiency, and ensure fair and free markets. Some well-known antitrust laws include the Sherman Act, the Clayton Act, and the Federal Trade Commission Act in the United States, and similar laws exist in many other countries around the world.

"Tars" is not a recognized medical term. However, "tarso-" is a prefix in anatomy that refers to the ankle or hind part of an organ. For example, the tarsal bones are the bones that make up the ankle and the rear part of the foot. Additionally, tarsus can refer to the thickened portion of the eyelid which contains the eyelashes. It is important to ensure you have the correct term when seeking medical information.

I believe you may have mixed up the terms "medicine" and "commerce." Commerce is a broad term that refers to the buying and selling of goods and services. It is not typically used in a medical context, so it does not have a specific medical definition. However, I can provide you with some related terms that might be helpful:

1. Medical commerce: This term generally refers to the business aspects of healthcare, such as the buying and selling of medical supplies, equipment, and services. It may also refer to the economic relationships between various stakeholders in the healthcare system, including providers, insurers, pharmaceutical companies, and patients.
2. Telemedicine commerce: This term specifically refers to the use of technology to facilitate remote consultations and transactions between healthcare providers and patients. Examples include online appointment scheduling, virtual consultations, and electronic prescribing.
3. Medical tourism: This is a form of commerce where people travel to other countries to receive medical treatment or procedures that may be less expensive or more accessible than in their home country. It can also refer to the business of providing medical services to international patients.
4. Healthcare marketing: This term refers to the activities and strategies used by healthcare organizations to promote their products, services, and brands to potential customers. It includes advertising, public relations, social media, content marketing, and other tactics designed to build awareness, generate leads, and drive sales.

I hope this information is helpful! Let me know if you have any further questions or concerns.

'Supreme Court Decisions' refer to the legal rulings made by the Supreme Court of the United States, which is the highest court in the federal judiciary of the US. These decisions are the final word on matters of federal law, including constitutional interpretation, and they establish precedents that guide future decision-making in federal and state courts. They can have significant impacts on various aspects of American society, politics, and law.

I'm sorry for any confusion, but "International Cooperation" is not a medical term. It refers to the collaboration and exchange of resources and information between countries or international organizations in various fields, including politics, economics, culture, environment, and security, among others. In the context of healthcare and medicine, international cooperation can involve joint research projects, sharing of data and clinical trial results, collaborative efforts to combat global health issues (such as infectious diseases or chronic conditions), capacity building in low-resource settings, and standardizing medical practices and guidelines across countries.

I'm sorry for any confusion, but there seems to be a misunderstanding. "Macau" is not a medical term or concept. It is a special administrative region located in southeastern China. If you have any questions related to medical terminology or health-related topics, please feel free to ask! I would be happy to help.

... or exogenous amino acids such as 4-fluorophenylalanine. Typically, these projects make use of re-coded nonsense suppressor tRNA ...
Atkinson, D. E.; Melvin, S.; Fox, S. W. (1951). "Effects of p-fluorophenylalanine on the growth of Lactobacillus arabinosus". ... where he investigated the synthesis of aromatic amino acids and effects of p-fluorophenylalanine in Lactobacillus arabinosus, ...
Furter R (February 1998). "Expansion of the genetic code: site-directed p-fluoro-phenylalanine incorporation in Escherichia ...
L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester): ... November 2004). "Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester ( ...
... p-fluorophenylalanine MeSH D12.125.072.050.685.500 - melphalan MeSH D12.125.072.050.767 - thyroxine MeSH D12.125.072.050. ...
Shop (R)-N-FMOC-α-Methyl-2-fluorophenylalanine, 98%, 98% ee, Thermo Scientific™ at Fishersci.ca ...
Structural Formula:Product Name:L-2-FluorophenylalanineCAS NO.:19883-78-4Appearance:White solid powd-Highfine Biotech
... or exogenous amino acids such as 4-fluorophenylalanine. Typically, these projects make use of re-coded nonsense suppressor tRNA ...
S)-N-Fmoc-alpha-methyl-2-fluorophenylalanine. Purity: 95%. [1172127-44-4], MFCD17019320. ... Fmoc-alpha-methyl-d-4-fluorophenylalanine. Purity: 95%. [1217777-84-8], MFCD08061622. ... Fmoc-alpha-methyl-l-4-fluorophenylalanine. Purity: 98%. [1175838-03-5], MFCD08061624. ...
1995) Aging effect on neutral amino acid transport at the blood-brain barrier measured with L-[2-18F]-fluorophenylalanine and ...
p Fluorophenylalanine use p-Fluorophenylalanine P Glycoprotein use ATP Binding Cassette Transporter, Subfamily B, Member 1 ...
2] and said protein has the activity to make the bacterium resistant to L-phenylalanine, fluorophenylalanine or 5[-]fluoro-DL- ...
Dunn NW, Holloway BW: Pleiotrophy of p-fluorophenylalanine-resistant and antibiotic hypersensitive mutants of Pseudomonas ...
p Fluorophenylalanine use p-Fluorophenylalanine P Glycoprotein use ATP Binding Cassette Transporter, Subfamily B, Member 1 ...
p Fluorophenylalanine use p-Fluorophenylalanine P Glycoprotein use ATP-Binding Cassette, Sub-Family B, Member 1 ...
p Fluorophenylalanine use p-Fluorophenylalanine P Glycoprotein use ATP-Binding Cassette, Sub-Family B, Member 1 ...
3-Fluoro-Phenylalanine. Molecular Weight [g/mol]. 184.19. logP. -1.31 (predicted). Sidechain logP. 2.75. ...
R)-4-FLUORO-PHENYLALANINE BENZYL ESTER TSOH SALT CAS:874336-37-5 AA1011T-R ...
Synonyms: BOC-L-3-FLUOROPHENYLALANINE. Molecule Formula: C14H18FNO4. Molecule Weight: 283.3. EINECS:. Appearance: Off-white to ...
Lhoas P. 1961; Mitotic haploidisation by treatment of Aspergillus niger diploids with p-fluoro-phenylalanine. Nature, Lond 190: ... Morpurgo G. 1961; Somatic segregation induced by p-fluorophenylalanine. Aspergillus News Letter 2:4 ...
Boc-alpha-methyl-L-2-Fluorophenylalanine 1389316-08-8. Boc-Pro-NMe(OMe) 115186-37-3 ...
Firnau G, Chirakal R, Sood S, Garnett S. Aromatic fluorination with xenon difluoride: l-3,4-dihydroxy-6-fluoro-phenylalanine. ...
Posted in 2004, Transactions , Tagged Buhse, Reyes, Sharpe, Tetrahymena vorax, The Effect of p-Fluoro-Phenylalanine on ... The Effect of p-Fluoro-Phenylalanine on Differentiation of the Macrostomal Form of the Polymorphic Ciliate, Tetrahymena vorax ... 097-05MS2315] The Effect of p-Fluoro-Phenylalanine on Differentiation of the Macrostomal Form of the Polymorphic Ciliate, ...
Radiochemical Synthesis of 2-[18F]Fluorophenylalanine * Asymmetric Mannich-Type Reaction of an α-Trifluoromethyl Amide ...
Find manufacturers and suppliers for Boc-L-3-Chlorophenylalanine, 114873-03-9. Synonyms: (S)-2-tert-Butoxycarbonylamino-3-(3-chloro-phenyl)-propionic acid; N-(tert-butoxycarbonyl)-3-chlorophenylalanine; phenylalanine, 3-chloro-N-[(1,1-dimethylethoxy)carbonyl]-
Fmoc-L-2-Fluorophenylalanine. *Boc-L-3-Fluorophenylalanine. *Fmoc-L-3-Fluorophenylalanine ...
Some cyto- and morphogenetic effects of para-fluorophenylalanine in tissue cultures of Nicotiana tabacum and Papaver bracteatum ...
PheF refers to para fluoro Phenylalanine, PheMe refers to para methyl Phenylalanine, PheNH2 refers to para amino Phenylalanine ...
Remarkably, we found that para-fluorophenylalanine-modified stapled peptide is the most potent inhibitors, which perturbs ...
... fluorophenylalanine ([18F]FDOPA) metabolism was investigated. Tissue activities for [18F]FDOPA and its labeled metabolites 3-O- ... fluorophenylalanine ([18F]FDOPA) metabolism was investigated. Tissue activities for [18F]FDOPA and its labeled metabolites 3-O- ... fluorophenylalanine ([18F]FDOPA) metabolism was investigated. Tissue activities for [18F]FDOPA and its labeled metabolites 3-O- ... fluorophenylalanine ([18F]FDOPA) metabolism was investigated. Tissue activities for [18F]FDOPA and its labeled metabolites 3-O- ...
Predominant contribution of L-type amino acid transporter to 4-borono-2-18F-fluoro-phenylalanine uptake in human glioblastoma ... fluorophenylalanine with relatively high-specific activity. J Label Compd Radiopharm. 2002;45(8):697-704 ...
Cattanéo, J.; Sigal, N.; Favard, A.; Segel, I.H. 1966: Inhibition by actinomycin D and by p-fluorophenylalanine of glycogen ...
By the use of suitable concentrations of p-fluorophenylalanine (PFP) in tissue cultures of tobacco, it is possible to maintain ...

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