Erythema Nodosum: An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.Leprosy, Lepromatous: A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.Leprostatic Agents: Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.Ascophyllum: A BROWN ALGAE closely related to FUCUS. It is found attached to rocks and boulders on the middle shore, primarily in the North Atlantic basin.Leprosy: A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.Leprosy, Borderline: A form of LEPROSY in which there are clinical manifestations of both principal types (lepromatous and tuberculoid). The disease may shift toward one of these two polar or principal forms.Sarcoidosis: An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Leprosy, Multibacillary: A form of LEPROSY classified by the World Health Organization for the purpose of treatment, based on clinical manifestations and skin smear results. Patients with multibacillary leprosy have six or more lesions with or without positive skin smear results for the causative agent MYCOBACTERIUM LEPRAE. Multibacillary leprosy encompasses borderline lepromatous, midborderline, and lepromatous leprosy.Serositis: Inflammation of a serous membrane.Uterine Cervical Erosion: Loss or destruction of the epithelial lining of the UTERINE CERVIX.Pyoderma Gangrenosum: An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.Tuberculosis, Cutaneous: Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS.Mycobacterium leprae: A species of gram-positive, aerobic bacteria that causes LEPROSY in man. Its organisms are generally arranged in clumps, rounded masses, or in groups of bacilli side by side.Periarthritis: Inflammation of the tissues around a joint. (Dorland, 27th ed)Scleral Diseases: General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.Skin DiseasesSeaweed: Multicellular marine macroalgae including some members of red (RHODOPHYTA), green (CHLOROPHYTA), and brown (PHAEOPHYTA) algae. They are widely distributed in the ocean, occurring from the tide level to considerable depths, free-floating (planktonic) or anchored to the substratum (benthic). They lack a specialized vascular system but take up fluids, nutrients, and gases directly from the water. They contain CHLOROPHYLL and are photosynthetic, but some also contain other light-absorbing pigments. Many are of economic importance as FOOD, fertilizer, AGAR, potash, or source of IODINE.Phaeophyta: A division of predominantly marine EUKARYOTA, commonly known as brown algae, having CHROMATOPHORES containing carotenoid PIGMENTS, BIOLOGICAL. ALGINATES and phlorotannins occur widely in all major orders. They are considered the most highly evolved algae because of their well-developed multicellular organization and structural complexity.

*  Leprosy - Erythema Nodosum Leprosum Support Group - Drugs.com

Erythema Nodosum Leprosum. Our support group helps people share their own experience. ... Home › Q & A › Support Groups › Leprosy - Erythema Nodosum Leprosum. Join the 'Leprosy - Erythema Nodosum Leprosum' group to ... Leprosy -- Erythema Nodosum Leprosum - I am researching the treatment for leprosy or its?. Posted 24 Aug 2009 • 1 answer ... Our support group for Leprosy - Erythema Nodosum Leprosum has 1 questions and 3 members. Updated 24 Aug 2009. ...
https://drugs.com/answers/support-group/leprosy-erythema-nodosum-leprosum/

*  DMOZ - Health: Conditions and Diseases: Skin Disorders: Erythema Nodosum

Erythema nodosum is an inflammation of the fat cells under the skin characterized by tender red nodules or lumps that are ... Patient: Erythema Nodosum Erythema nodosum is a condition that causes red nodules, most commonly on the shins. Factsheet with ... Erythema nodosum is an inflammation of the fat cells under the skin characterized by tender red nodules or lumps that are ... Wikipedia: Erythema nodosum Encyclopedia article on this condition, its clinical manifestations, diagnosis, causes and ...
dmoztools.net/Health/Conditions_and_Diseases/Skin_Disorders/Erythema_Nodosum/

*  Erythema Nodosum | Kendall Regional Medical Center | Miami, FL

Learn more about Erythema Nodosum at Kendall Regional Medical Center DefinitionCausesRisk ... Erythema nodosum. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T116219/Erythema-nodosum ... Erythema nodosum. DermNet NZ website. Available at: http://www.dermnetnz.org/vascular/erythema-nodosum.html. Updated August 1, ... Erythema nodosum is the name given to tender lumps on the legs and sometimes the arms. They are caused by inflammation of the ...
https://kendallmed.com/hl/?/100540/Erythema-nodosa&com.dotmarketing.htmlpage.language=1

*  John Libbey Eurotext - European Journal of Dermatology - A comparative study of the T cell receptor Vb repertoire in erythema...

Erythema nodosum is a typical cutaneous manifestation associated with inflammatory bowel disease, although the incidence is ... We have seen two cases of erythema nodosum in association with Crohn's disease and ulcerative colitis, and examined the T cell ... Our results showed that Vb 14, 15, 17 and 20 were commonly expressed in the lesional skin of erythema nodosum associated with ... A comparative study of the T cell receptor Vb repertoire in erythema nodosum associated with Crohn's disease and ulcerative ...
jle.com/en/revues/ejd/e-docs/a_comparative_study_of_the_t_cell_receptor_vb_repertoire_in_erythema_nodosum_associated_with_crohns_disease_and_ulcerative_colitis_100662/article.phtml?cle_doc=00018936

*  DMOZ - Health: Conditions and Diseases: Immune Disorders: Auto-Immune: Sarcoidosis

Information on the illness including images of lupus pernio, erythema nodosum, and chest imaging. Article by Mark H. Belfer, ...
dmoztools.net/Health/Conditions_and_Diseases/Immune_Disorders/Auto-Immune/Sarcoidosis/

*  Definition for erythema nodosum leprosum

erythema nodosum leprosum definition: an inflammatory problem of leprosy that leads to painful skin lesions regarding arms and ... Definition for "erythema nodosum leprosum" *an inflammatory problem of leprosy that leads to… ... How would you define erythema nodosum leprosum?. All the definitions on AZdictionary were written by people just like you. ...
https://azdictionary.com/definition/erythema nodosum leprosum

*  Rev Electron Biomed / Electron J Biomed 2005;2:67-72 Enz et al.. ERYTHEMA NODOSUM AND PROLONGED FEVER...

An skin biopsy confirmed the diagnose of erythema nodosum. Erythema nodosum has been described in four kind of diseases: ... Erythema nodosum, Prolonged fever Palabras Clave: Hiperparatiroidismo secundario, eritema nodoso, sindrome febril INTRODUCTION ... Prolonged fever and erythema nodosum seem to be one of the uncommon clinical expressions of the secondary hyperparathyroidism. ... ERYTHEMA NODOSUM AND PROLONGED FEVER ASSOCIATED TO SECONDARY HYPERPARATHYROIDISM. Enz P*, Musso C**, Luque K**, Kowalczuk A*, ...
biomed.uninet.edu/2005/n2/enz-en.html

*  The Infectivity of Erythema Nodosum | The BMJ

The Infectivity of Erythema Nodosum. Br Med J 1926; 2 doi: https://doi.org/10.1136/bmj.2.3441.1196-c (Published 18 December ...
bmj.com/content/2/3441/1196.4

*  DermIS - Erythema Nodosum (image)

Erythema Nodosum (29) differential diagnoses. Erythema Induratum Bazin (1)Lepra Lepromatosa (1)Tertiary Lues (3)Behçet's ... Panarteritis Nodosa Kussmaul-Maier (15)Vasculitis Nodularis Montgomery (2)Drug Eruption (43)Sweet's Syndrome (47)Rothmann-Makai ...
dermis.net/dermisroot/en/30448/image.htm

*  Image Library - erythema nodosum

acquired disorders of the dermis and subcutaneous tissue / subcutaneous tissue disorders / septal panniculitis / erythema ... acquired disorders of the dermis and subcutaneous tissue / subcutaneous tissue disorders / septal panniculitis / erythema ...
https://dermquest.com/image-library/image/5044bfcfc97267166cd62b9c

*  My Colitis and Getting Diagnosed with Erythema Nodosum

My ulcerative colitis eventually led to an additional diagnosis of erythema nodosum which included painful bites in my legs. ... i have had erythema nodosum since 1992 when my mom died. i don't know. if that's what triggered it. i also have mitochondrial ... My Colitis and Getting Diagnosed with Erythema Nodosum. By KB on October 26, 2012 in Strange Symptoms ... I can't find any information on Erythema Nodosum and itchiness.. Well wishes to you!. Thanks,. Richele ...
ihaveuc.com/colitis-diagnosed-erythema-nodosum/

*  Homeopathy

Erythema Nodosum is a hypersensitivity reaction causing a localized inflammatory infiltrate that... ...
https://hpathy.com/author/ashishsharma/

*  Bacteria - Glossary Definition

Erythema Nodosum. ...the condition "...Chlamydia, tuberculosis, and other bacterial and fungal infections may also be ... associated with erythema nodosum, but fungal infections involving only the skin, such as athlete's foot, are not..." ...
https://diagnose-me.com/definition-of/bacteria.php

*  What causes multiple reddish brown ovals, mildly indented, on the tibia? - Answered by top doctors on HealthTap

In brief: ?Erythema Nodosum While there are certainly other causes, en is a common hypersensitivity (allergic reaction of sorts ... In brief: ?Erythema Nodosum While there are certainly other causes, en is a common hypersensitivity (allergic reaction of sorts ...
https://healthtap.com/user_questions/76110-what-causes-multiple-reddish-brown-ovals-mildly-indented-on-the-tibia

*  Cortisone Injection: Knee, Hip, Back, and Side Effects Patient Comments: Cortisone Injection - Experience - Viewers Share...

Erythema Nodosum *Erythema nodosum is a skin inflammation that results in reddish, painful, tender lumps most commonly located ...
https://medicinenet.com/cortisone_injection/patient-comments-205.htm

*  Cellulitis Index by MedicineNet.com

Erythema Nodosum *Erythema nodosum is a skin inflammation that results in reddish, painful, tender lumps most commonly located ...
https://medicinenet.com/cellulitis/index.htm

*  Why is triple response absent in Leprosy?

Leprosy -- Erythema Nodosum Leprosum - I am researching the treatment for leprosy or its?. Posted 24 Aug 2009 • 1 answer ...
https://drugs.com/answers/why-is-triple-response-absent-in-leprosy-520338.html

*  10. antileprotic

ADVERSE EFFECTS OF DAPSONE Type 2 Type 1 • Delayed hypersensitivity • Erythema nodosum leprosum • IV • Humoral antibody ...
https://slideshare.net/prasadvj_s/10-antileprotic

*  Amabelz (Estradiol And Norethindrone Acetate Tablets): Side Effects, Interactions, Warning, Dosage & Uses

Chloasma or melasma that may persist when drug is discontinued; erythema multiforme; erythema nodosum; hemorrhagic eruption; ...
rxlist.com/amabelz-drug.htm

*  Sarcoidosis Overview

Erythema nodosum is a rash of red or reddish-purple bumps on your ankles and shins. The rash may be warm and tender to the ... Lofgren's syndrome may cause fever, enlarged lymph nodes, arthritis (usually in the ankles), and/or erythema nodosum (er-ih-THE ...
netwellness.org/healthtopics/sarcoidosis/overviewnih.cfm

*  Surgery Definition - What is Healing By Secondary Intention? - Medical Zone

Symptom Checker - Erythema Multiforme * Symptom Checker - Erythema Nodosum * Symptom Checker - Erythema Annular Skin Lesions ...
medicalzone.net/surgery-definition---what-is-healing-by-secondary-intention.html

*  Surgery Definition - What is Hartmann's Procedure? - Medical Zone

Symptom Checker - Erythema Multiforme * Symptom Checker - Erythema Nodosum * Symptom Checker - Erythema Annular Skin Lesions ...
medicalzone.net/surgery-definition---what-is-hartmannrsquos-procedure.html

*  What Is Microbiology - West Nile Encephalitis - Medicalrealm

What Is Dermatology - Erythema Nodosum * What Is Dermatology - Mycosis Fungoides * What Is Dermatology - Infancy Hemangioma ...
medicalrealm.net/what-is-microbiology---west-nile-encephalitis.html

*  Rx Scoops | Drugs Detail

erythema nodosum. loss of hair. Stevens-Johnson syndrome. erythema multiforme. toxic epidermal necrolysis. ...
rxscoops.com/drugsdetail.php?drugsid=4319

*  What Is Microbiology - Haemophilus Influenzae Infection - Medicalrealm

What Is Dermatology - Erythema Nodosum * What Is Dermatology - Mycosis Fungoides * What Is Dermatology - Infancy Hemangioma ...
medicalrealm.net/what-is-microbiology---haemophilus-influenzae-infection.html

Erythema nodosumBorderline lepromatous leprosy: Borderline lepromatous leprosy is a skin condition with numerous, symmetrical skin lesions.Necrolytic acral erythema: Necrolytic acral erythema is a cutaneous condition that is a manifestation of hepatitis C viral infection or zinc deficiency.Lucio's phenomenon: Lucio's phenomenon is an unusual reaction seen almost exclusively in patients from the Caribbean and Mexico with diffuse, lepromatous leprosy, especially in untreated cases. It is characterised by recurrent crops of large, sharply demarcated, ulcerative lesions, affecting mainly the lower extremities, but may generalise and become fatal as a result of secondary bacterial infection and sepsis.Phlorotannin: Phlorotannins are a type of tannins found in brown algae such as kelps and rockweeds or sargassacean species, and in a lower amount also in some red algae.http://eurekamag.LeprosyBorderline leprosyNeurosarcoidosis: Neurosarcoidosis (sometimes shortened to neurosarcoid) refers to sarcoidosis, a condition of unknown cause featuring granulomas in various tissues, involving the central nervous system (brain and spinal cord). It can have many manifestations, but abnormalities of the cranial nerves (a group of twelve nerves supplying the head and neck area) are the most common.Pyoderma gangrenosumScrofuloderma: (ILDS A18.462)Mycobacterium lepromatosis: Mycobacterium lepromatosis is a bacterium that, along with Mycobacterium leprae, causes leprosy (Hansen's disease). It was only recently discovered, in 2008.EnthesopathyWater injection (oil production): Water injection or water flooding refers to the method in the oil industry where water is injected into the reservoir, usually to increase pressure and thereby stimulate production. Water injection wells can be found both on- and offshore, to increase oil recovery from an existing reservoir.Transplacental: Transplacental refers to the ability of a toxin or pathogen to cross the physical and biological barriers of the placenta separating the mother and fetus, to whom such substances may be dangerous. This would include, for example, HIV and the drug thalidomide.Seaweed farming: Seaweed farming is the practice of cultivating and harvesting seaweed. In its simplest form, it consists of the management of naturally found batches.Ecklonia stolonifera: Ecklonia stolonifera (Japanese: ツルアラメ, turuarame) is a brown alga species in the genus Ecklonia found in the Sea of Japan. It is an edible species traditionally eaten in Japan.

(1/128) Immune complexes and complement hypercatabolism in patients with leprosy.

The occurrence of immune complexes in the serum and the level of the C3 breakdown product C3d in the plasma from patients with leprosy were studied by quantitative methods and the results were compared in various forms of the disease. These studies were performed on sixty-two samples from twenty-six patients. The serum 125I-C1q binding activity was found to be increased by more than 2 s.d., as compared to the normal values, in most of the sera from patients with erythema nodosum leprosum (ENL) (80%) and uncomplicated lepromatous leprosy (82%), but also in the sera from patients with tuberculoid leprosy (58%). In vitro studies suggested that immune complexes involving mycobacterial antigens were present in leprosy sera. An increased C3d level (greater than 2s.d.) was also found in most of the plasma from patients with ENL (70%), but rarely in the plasma from patients with uncomplicated lepromatous leprosy (18%) and never in tuberculoid leprosy patients' plasma. The absence of a significant correlation between the 125I-C1q binding activity and the C3d level in leprosy patients may suggest that extravascular immune complexes are involved in the complement activation occurring in ENL. The quantitation of C3d in plasma may be of some practical interest in the early diagnosis of ENL complications of leprosy.  (+info)

(2/128) Erythema nodosum: etiologic and predictive factors in a defined population.

OBJECTIVE: To examine the frequency and features of erythema nodosum (EN), establish disease associations, and identify the optimal set of predictors for the occurrence of secondary EN. METHODS: We performed a retrospective study of an unselected population of patients 14 years and older with biopsy-proven EN diagnosed at a referral hospital between 1988 and 1997. Patients were classified as having either idiopathic EN or EN secondary to other diseases if the skin nodules occurred in the context of a well-defined disease, or if there was a precipitating event in close temporal proximity to the onset of EN. RESULTS: One hundred six patients (82 women) were diagnosed as having biopsy-proven EN. At the time of diagnosis, no precipitating events or underlying diseases were identified in 36.8% of patients. Sarcoidosis and nonstreptococcal upper respiratory tract infections (URI) were the most common conditions associated with secondary EN. Only 1 of 35 patients with an initial diagnosis of idiopathic EN and a followup of at least 1 year was finally diagnosed as having secondary EN. The best predictive model of secondary EN included an abnormal results on a chest radiograph, a previous history of nonstreptococcal URI, and a significant change in antistreptolysin O (ASO) titer in 2 consecutive determinations performed in a 2-4-week interval. Also, the presence of peripheral synovitis, a positive tuberculin skin test, and a history of diarrhea suggested the presence of secondary EN. This model showed high sensitivity and specificity. CONCLUSION: Idiopathic EN is common. A basic procedure including careful medical history-taking, a physical examination for peripheral synovitis, 2 consecutive ASO determinations, a tuberculin skin test, and chest radiography may be sufficient to diagnose EN.  (+info)

(3/128) Erythema nodosum in Israeli children.

BACKGROUND: Erythema nodosum, although uncommon in children, is the most frequent form of panniculitis in pediatrics. EN has been associated with various infections and chronic inflammations, and its course varies with age, gender, and racial and geographic factors. There is no information on EN in Israeli children. OBJECTIVES: To examine the clinical course of EN and the conditions with which it is associated in Israeli children. METHODS: We conducted a retrospective study of 24 children with a diagnosis of EN who presented at our Center over a 10 year period (1989-98). RESULTS: EN was more frequent in females than males (ratio 2:1) due to a cluster of adolescent girls. The mean duration of the skin manifestation was 18 days. The course was benign in all patients. Streptococcal infection was the most common cause (25%), followed by Epstein-Barr virus infection (18%) and inflammatory bowel disease (13%). In one-third of cases, no specific cause could be identified. Tuberculosis, an important cause of EN in the past, was not found in our patients. CONCLUSIONS: Most cases of EN in Israeli children are related to streptococcal and EBV infections or to chronic inflammatory conditions. Despite the increase in tuberculosis morbidity in Israel during recent years, we found no association of EN and tuberculosis in our study.  (+info)

(4/128) T cell-monocyte contact enhances tumor necrosis factor-alpha production in response to Mycobacterium leprae.

Tumor necrosis factor (TNF)-alpha has been implicated as a key factor in inflammatory processes occurring in erythema nodosum leprosum (ENL). In the present study, the roles of soluble factors and contact-mediated interaction in the induction of enhanced TNF-alpha secretion in leprosy have been investigated. In vitro studies have demonstrated that Mycobacterium leprae per se is a poor stimulus for TNF-alpha production by purified monocytes obtained from normal subjects, although this could be enhanced by either exogenous interferon-gamma or cell contact with fixed activated T lymphocytes. Further investigations demonstrated that monocyte-T cell contact enhanced M. leprae-induced TNF-alpha production by peripheral blood mononuclear cells of ENL patients and was modulated by blocking antibodies to CD40L, CD69, and CD18. These results suggest that physical contact with T cells isolated from patients in a particular disease state (ENL) modulates monocyte function and may contribute to the secretion of proinflammatory cytokines described in ENL.  (+info)

(5/128) Concurrence of sarcoidosis and aortitis: case report and review of the literature.

Takayasu arteritis (TA) is a rare manifestation of systemic large vessel vasculitis which affects predominantly the aorta and its main branches, but often remains unrecognised owing to delayed diagnosis and non-characteristic clinical features. Sarcoidosis, too, is a systemic inflammatory disease which can affect virtually any organ system. Reports about the coincidence of both diseases have appeared. The case presented here is characterised by a significant time lag between detection of TA and appearance of clinical signs of sarcoidosis. The woman, now 39 years old, had erythema nodosum, circumscript alopecia, and recurrent uveitis, which dated back to 1980 and was attributed to sarcoidosis. At least 12 years later aortic valve insufficiency with progressive cardiac failure developed. Histology performed at the time of aortic valve prosthesis in 1997 disclosed a diagnosis of TA, which was confined to the aortic root. Incidentally, sarcoidosis was diagnosed in adjacent lymph nodes. A thorough check up failed to detect further manifestations of TA; thus, possibly, the patients had aortitis similar to, but not identical with, TA. Several related cases previously reported are discussed, suggesting that both diseases may be inherently related as they are characterised by certain non-specific, immunoinflammatory abnormalities. This case report suggests that the prevalence of TA, or related forms of arteritis, may be higher than expected and should be considered, especially in younger patients with non-characteristic cardiovascular symptoms and suspected systemic inflammatory disease. Moreover, the association with sarcoidosis in this and other previously described cases suggests that the two diseases may be related and that TA or TA-like vasculitis may even be a complication of sarcoidosis.  (+info)

(6/128) Anti-inflammatory drugs block cytokine mRNA accumulation in the skin and improve the clinical condition of reactional leprosy patients.

The aim of this study was to investigate in what ways in vivo anti-inflammatory treatment affects cytokine mRNA expression in situ in both erythema nodosum leprosum and reversal reaction patients. Serial biopsies were collected from the patients undergoing leprosy reactions before and during pentoxifylline (n = 7) or thalidomide (n = 3) treatment for erythema nodosum leprosum and prednisone (n = 3) for reversal reaction. Clinical evolution of the skin lesion was assessed during the study and semiquantitative reverse transcription-polymerase chain reaction was used to investigate cytokine mRNA expression at the lesion site. Results showed expression of interferon-gamma, interleukin-6, interleukin-10, interleukin-12 p40, and tumor necrosis factor-alpha in all patients tested at the onset of reactional episodes, but interleukin-4 mRNA was rarely detected in the lesions (n = 4). Follow-up analysis showed that, irrespective of the drugs used, tumor necrosis factor-alpha mRNA was diminished in 10 of the 13 patients tested. A concomitant decrease of mRNA accumulation was also observed for interferon-gamma (nine of 11 patients), interleukin-6 (nine of 11), and interleukin-12 p40 (six of eight). An inhibitory effect on interleukin-10 mRNA was likewise seen after thalidomide and pentoxifylline, but not subsequent to prednisone treatment. The data also demonstrated that cytokine mRNA inhibition correlates to the resolution of the inflammatory response in situ (n = 10), whereas the persistence/enhancement of cytokine message expression after treatment was associated with worsening of the skin condition, as seen in three erythema nodosum leprosum patients whose maintenance of local inflammation was accompanied by the appearance/persistence of interleukin-4 gene expression in situ subsequent to anti-inflammatory treatment. In summary, the participation of cytokines in leprosy inflammatory episodes seems to be directly associated with the patients' clinical evolution following therapy for reaction.  (+info)

(7/128) Cardiac and great vessel thrombosis in Behcet's disease.

Behcet's disease (BD) is a chronic relapsing systemic vasculitis in which orogenital ulceration is a prominent feature. The disease affects many systems and causes hypercoagulability. We present a 27-year-old male patient who exhibited widespread great vessel thrombosis including right atrial and ventricular thrombi in the setting of right-sided infectious endocarditis and orogenital aphthous ulcerations and erythema nodosum due to BD. We reviewed the enigmatic prothrombotic state of BD, and discuss our prior experiences in this field.  (+info)

(8/128) Clinicopathologic evaluation of nodular cutaneous lesions of Behcet syndrome.

Among the cutaneous manifestations, nodular lesions are rather common in Behcet syndrome. The histologic nature of these lesions has been a matter of controversy. To establish their distinguishing features, biopsy specimens from nodular lesions of 24 patients with Behcet syndrome, 25 with nodular vasculitis (NV), and 20 with erythema nodosum (EN) were compared. Statistical analysis revealed insignificant differences between most of the histologic features of Behced syndrome and NV. However, neutrophil-predominating infiltrate in the subcutis was more common in Behcet syndrome, while necrosis and granuloma formation were encountered more frequently in NV. The differences between Behced syndrome and EN were more significant. Septal panniculitis, lymphocyte-predominating infiltrate, absence of many vascular changes as well as vasculitis, and necrosis were features in favor of EN. Nodular lesions of Behcet syndrome are mainly neutrophilic vascular reactions with histologic features similar to NV but significantly differing from EN associated with other systemic diseases.  (+info)



Leprosum


  • Join the ' Leprosy - Erythema Nodosum Leprosum ' group to help and get support from people like you. (drugs.com)
  • Our support group for Leprosy - Erythema Nodosum Leprosum has 1 questions and 3 members. (drugs.com)
  • Leprosy -- Erythema Nodosum Leprosum - I am researching the treatment for leprosy or its? (drugs.com)
  • How would you define erythema nodosum leprosum? (azdictionary.com)

causes


  • Erythema nodosum is a condition that causes red nodules, most commonly on the shins. (dmoztools.net)

commonly


  • Our results showed that Vb 14, 15, 17 and 20 were commonly expressed in the lesional skin of erythema nodosum associated with both Crohn's disease and ulcerative colitis. (jle.com)

skin


  • Erythema nodosum is an inflammation of the fat cells under the skin characterized by tender red nodules or lumps that are usually seen on both shins. (dmoztools.net)
  • We have seen two cases of erythema nodosum in association with Crohn's disease and ulcerative colitis, and examined the T cell receptor (TCR) Vb repertoire on the infiltrating lymphocytes in the skin and peripheral blood. (jle.com)

Topics


  • Available at: http://www.dynamed.com/topics/dmp~AN~T116219/Erythema-nodosum Updated February 23, 2016. (kendallmed.com)

rare


  • Erythema nodosum is a typical cutaneous manifestation associated with inflammatory bowel disease, although the incidence is rare. (jle.com)