Xylose is a monosaccharide, a type of sugar, that is commonly found in woody plants and fruits, and it is used in medical testing to assess the absorptive capacity of the small intestine.
Enzymes that catalyze the interconversion of aldose and ketose compounds.
A five-carbon sugar alcohol derived from XYLOSE by reduction of the carbonyl group. It is as sweet as sucrose and used as a noncariogenic sweetener.
An enzyme that plays a role in the PENTOSES and GLUCURONATES interconversion pathway by catalyzing the oxidation of XYLITOL to D-xylulose. This enzyme has been found to be specific for NAD+.
The decarboxylation product of UDPglucuronic acid, which is used for formation of the xylosides of seryl hydroxyl groups in mucoprotein synthesis. Also forms plant xylans.
Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.
An enzyme that catalyzes reversibly the oxidation of an aldose to an alditol. It possesses broad specificity for many aldoses. EC 1.1.1.21.
Polysaccharides consisting of xylose units.
Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.
Arabinose is a simple, pentose sugar (a monosaccharide with five carbon atoms) that is a constituent of various polysaccharides and glycosides, particularly found in plant tissues and some microorganisms, and can be metabolized in humans as a source of energy through the pentose phosphate pathway.
A group of enzymes that catalyze the hydrolysis of alpha- or beta-xylosidic linkages. EC 3.2.1.8 catalyzes the endo-hydrolysis of 1,4-beta-D-xylosidic linkages; EC 3.2.1.32 catalyzes the endo-hydrolysis of 1,3-beta-D-xylosidic linkages; EC 3.2.1.37 catalyzes the exo-hydrolysis of 1,4-beta-D-linkages from the non-reducing termini of xylans; and EC 3.2.1.72 catalyzes the exo-hydrolysis of 1,3-beta-D-linkages from the non-reducing termini of xylans. Other xylosidases have been identified that catalyze the hydrolysis of alpha-xylosidic bonds.
A class of carbohydrates that contains five carbon atoms.
Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.
Enzymes which catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in XYLANS.
A disaccharide consisting of two glucose units in beta (1-4) glycosidic linkage. Obtained from the partial hydrolysis of cellulose.
The study, utilization, and manipulation of those microorganisms capable of economically producing desirable substances or changes in substances, and the control of undesirable microorganisms.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that is not known to be pathogenic for man, animals, or plants. Its organisms are spoilers for beers and ciders and in sweet English ciders they are the causative agents of a secondary fermentation known as "cider sickness." The species Z. mobilis is used for experiments in molecular genetic studies.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
A xylosidase that catalyses the random hydrolysis of 1,3-beta-D-xylosidic linkages in 1,3-beta-D-xylans.
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.
Process by which micro-organisms adapt quickly to a preferred rapidly-metabolizable intermediate through the inhibition or repression of genes related to CATABOLISM of less preferred source(s).
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
Polysaccharides are complex carbohydrates consisting of long, often branched chains of repeating monosaccharide units joined together by glycosidic bonds, which serve as energy storage molecules (e.g., glycogen), structural components (e.g., cellulose), and molecular recognition sites in various biological systems.
A pentose active in biological systems usually in its D-form.
Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.

Tropical enteropathy in Rhodesia. (1/859)

Tropical enteropathy, which may be related to tropical sprue, has been described in many developing countries including parts of Africa. The jejunal changes of enteropathy are seen in Rhodesians of all social and racial categories. Xylose excretion, however, is related to socioeconomic status, but not race. Upper socioeconomic Africans and Europeans excrete significantly more xylose than lower socioeconomic Africans. Vitamin B12 and fat absorption are normal, suggesting predominant involvement of the proximal small intestine. Tropical enteropathy in Rhodesia is similar to that seen in Nigeria but is associated with less malabsorption than is found in the Caribbean, the Indian subcontinent, and South East Asia. The possible aetiological factors are discussed. It is postulated that the lighter exposure of upper class Africans and Europeans to repeated gastrointestinal infections may accound for their superior xylose absorption compared with Africans of low socioeconomic circumstances. It is further suggested that the milder enteropathy seen in Africa may be explained by a lower prevalence of acute gastroenteritis than in experienced elsewhere in the tropics.  (+info)

Uridine diphosphate xylosyltransferase activity in cartilage from manganese-deficient chicks. (2/859)

The glycosaminoglycan content of cartilage is decreased in manganese deficiency in the chick (perosis). The activity of xylosyltransferase, the first enzyme in the biosynthetic pathway of sulphated glycosaminoglycans, was studied in the epiphysial cartilage of 4-week-old chicks which had been maintained since hatching on a manganese-deficient diet. Enzymic activity was measured by the incorporation of [14C]xylose from UDP-[14C]xylose into trichloroacetic acid precipitates. Optimal conditions for the xylosyltransferase assay were established and shown to be the same for both control and manganese-deficient cartilage. Assay of the enzyme by using an exogenous xylose acceptor showed no difference in xylosyltransferase activity between control and manganese-deficient tissue. Further, the extent of xylose incorporation was greater in manganese-deficient than in control cartilage preparations, suggesting an increase in xylose-acceptor sites on the endogenous acceptor protein in the deficient cartilage. 35S turnover in the manganese-deficient cartilage was also increased. The data suggest that the decreased glycosaminoglycan content in manganese-deficient cartilage is due to decreased xylosylation of the acceptor protein plus increased degradation of glycosaminoglycan.  (+info)

Purification and some chemical properties of 30 kDa Ginkgo biloba glycoprotein, which reacts with antiserum against beta 1-->2 xylose-containing N-glycans. (3/859)

From the seeds of Ginkgo biloba, a glycoprotein, which is a major component that reacts with an antiserum against beta 1-->2 xylose-containing N-glycans, has been purified and characterized. The N-terminal amino acid sequence of the purified glycoprotein was H-K-A-N-X-V-T-V-A-F-V-M-T-Q-H-L-L-F-G-Q-. The molecular mass was estimated to be 17 kDa and 16 kDa by SDS-PAGE under reducing conditions, however, the molecular mass of this glycoprotein in the native state was 30,762 by MALDI-TOF MS, suggesting that this glycoprotein consists of two subunits; one is glycosylated and the other is not. The structure of N-glycan linked to this glycoprotein (designated 30 kDa GBGP) was identified as Man3Fuc1Xyl1GlcNAc2, which is the predominant N-glycan linked to the storage glycoproteins in the same seeds (Kimura, Y et al. (1998) Biosci. Biotechnol. Biochem. 62, 253-261). From the peptic digest of the carboxymethylated glycosylated subunit, one glycopeptide was purified by RP-HPLC and the amino acid sequence was identified as H-K-A-N-N(Man3Fuc1Xyl1Glc-NAc2)-V-T-V-A-F, which corresponded to the N-terminal amino acid sequence.  (+info)

A mutated PtsG, the glucose transporter, allows uptake of D-ribose. (4/859)

Mutations arose from an Escherichia coli strain defective in the high (Rbs/ribose) and low (Als/allose and Xyl/xylose) affinity D-ribose transporters, which allow cells to grow on D-ribose. Genetic tagging and mapping of the mutations revealed that two loci in the E. coli linkage map are involved in creating a novel ribose transport mechanism. One mutation was found in ptsG, the glucose-specific transporter of phosphoenolpyruvate:carbohydrate phosphotransferase system and the other in mlc, recently reported to be involved in the regulation of ptsG. Five different mutations in ptsG were characterized, whose growth on D-ribose medium was about 80% that of the high affinity system (Rbs+). Two of them were found in the predicted periplasmic loops, whereas three others are in the transmembrane region. Ribose uptakes in the mutants, competitively inhibited by D-glucose, D-xylose, or D-allose, were much lower than that of the high affinity transporter but higher than those of the Als and Xyl systems. Further analyses of the mutants revealed that the rbsK (ribokinase) and rbsD (function unknown) genes are involved in the ribose transport through PtsG, indicating that the phosphorylation of ribose is not mediated by PtsG and that some unknown metabolic function mediated by RbsD is required. It was also found that D-xylose, another sugar not involved in phosphorylation, was efficiently transported through the wild-type or mutant PtsG in mlc-negative background. The efficiencies of xylose and glucose transports are variable in the PtsG mutants, depending on their locations, either in the periplasm or in the membrane. In an extreme case of the transmembrane change (I283T), xylose transport is virtually abolished, indicating that the residue is directly involved in determining sugar specificity. We propose that there are at least two domains for substrate specificity in PtsG with slightly altered recognition properties.  (+info)

Factors affecting counteraction by methylamines of urea effects on aldose reductase. (5/859)

The concentration of urea in renal medullary cells is high enough to affect enzymes seriously by reducing Vmax or raising Km, yet the cells survive and function. The usual explanation is that the methylamines found in the renal medulla, namely glycerophosphocholine and betaine, have actions opposite to those of urea and thus counteract its effects. However, urea and methylamines have the similar (not counteracting) effects of reducing both the Km and Vmax of aldose reductase (EC 1.1.1.21), an enzyme whose function is important in renal medullas. Therefore, we examined factors that might determine whether counteraction occurs, namely different combinations of assay conditions (pH and salt concentration), methylamines (glycerophosphocholine, betaine, and trimethylamine N-oxide), substrates (DL-glyceraldehyde and D-xylose), and a mutation in recombinant aldose reductase protein (C298A). We find that Vmax of both wild-type and C298A mutant generally is reduced by urea and/or the methylamines. However, the effects on Km are much more complex, varying widely with the combination of conditions. At one extreme, we find a reduction of Km of wild-type enzyme by urea and/or methylamines that is partially additive, whereas at the other extreme we find that urea raises Km for D-xylose of the C298A mutant, betaine lowers the Km, and the two counteract in a classical fashion so that at a 2:1 molar ratio of betaine to urea there is no net effect. We conclude that counteraction of urea effects on enzymes by methylamines can depend on ion concentration, pH, the specific methylamine and substrate, and identity of even a single amino acid in the enzyme.  (+info)

Mutations in catabolite control protein CcpA separating growth effects from catabolite repression. (6/859)

Carbon catabolite repression in Bacillus megaterium is mediated by the transcriptional regulator CcpA. A chromosomal deletion of ccpA eliminates catabolite repression and reduces the growth rate on glucose. We describe four single-amino-acid mutations in CcpA which separate the growth effect from catabolite repression, suggesting distinct regulatory pathways for these phenotypes.  (+info)

Transport and utilization of hexoses and pentoses in the halotolerant yeast Debaryomyces hansenii. (7/859)

Debaryomyces hansenii is a yeast species that is known for its halotolerance. This organism has seldom been mentioned as a pentose consumer. In the present work, a strain of this species was investigated with respect to the utilization of pentoses and hexoses in mixtures and as single carbon sources. Growth parameters were calculated for batch aerobic cultures containing pentoses, hexoses, and mixtures of both types of sugars. Growth on pentoses was slower than growth on hexoses, but the values obtained for biomass yields were very similar with the two types of sugars. Furthermore, when mixtures of two sugars were used, a preference for one carbon source did not inhibit consumption of the other. Glucose and xylose were transported by cells grown on glucose via a specific low-affinity facilitated diffusion system. Cells derepressed by growth on xylose had two distinct high-affinity transport systems for glucose and xylose. The sensitivity of labeled glucose and xylose transport to dissipation of the transmembrane proton gradient by the protonophore carbonyl cyanide m-chlorophenylhydrazone allowed us to consider these transport systems as proton symports, although the cells displayed sugar-associated proton uptake exclusively in the presence of NaCl or KCl. When the V(max) values of transport systems for glucose and xylose were compared with glucose- and xylose-specific consumption rates during growth on either sugar, it appeared that transport did not limit the growth rate.  (+info)

The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation. (8/859)

The factor catalyzing the first step in the synthesis of the characteristic pentaglycine interpeptide in Staphylococcus aureus peptidoglycan was found to be encoded by the essential gene fmhB. We have analyzed murein composition and structure synthesized when fmhB expression is reduced. The endogenous fmhB promoter was substituted with the xylose regulon from Staphylococcus xylosus, which allowed glucose-controlled repression of fmhB transcription. Repression of fmhB reduced growth and triggered a drastic accumulation of uncrosslinked, unmodified muropeptide monomer precursors at the expense of the oligomeric fraction, leading to a substantial decrease in overall peptidoglycan crosslinking. The composition of the predominant muropeptide was confirmed by MS to be N-acetylglucosamine-(beta-1,4)-N-acetylmuramic acid(-L-Ala-D-iGln-L-Lys-D-Ala-D-Ala), proving that FmhB is involved in the attachment of the first glycine to the pentaglycine interpeptide. This interpeptide plays an important role in crosslinking and stability of the S. aureus cell wall, acts as an anchor for cell wall-associated proteins, determinants of pathogenicity, and is essential for the expression of methicillin resistance. Any shortening of the pentaglycine side chain reduces or even abolishes methicillin resistance, as occurred with fmhB repression. Because of its key role FmhB is a potential target for novel antibacterial agents that could control the threat of emerging multiresistant S. aureus.  (+info)

Xylose is a type of sugar that is commonly found in plants and wood. In the context of medical definitions, xylose is often used in tests to assess the function of the small intestine. The most common test is called the "xylose absorption test," which measures the ability of the small intestine to absorb this sugar.

In this test, a patient is given a small amount of xylose to drink, and then several blood and/or urine samples are collected over the next few hours. The amount of xylose that appears in these samples is measured and used to determine how well the small intestine is absorbing nutrients.

Abnormal results on a xylose absorption test can indicate various gastrointestinal disorders, such as malabsorption syndromes, celiac disease, or bacterial overgrowth in the small intestine.

Aldose-ketose isomerases are a group of enzymes that catalyze the interconversion between aldoses and ketoses, which are different forms of sugars. These enzymes play an essential role in carbohydrate metabolism by facilitating the reversible conversion of aldoses to ketoses and vice versa.

Aldoses are sugars that contain a carbonyl group (a functional group consisting of a carbon atom double-bonded to an oxygen atom) at the end of the carbon chain, while ketoses have their carbonyl group located in the middle of the chain. The isomerization process catalyzed by aldose-ketose isomerases helps maintain the balance between these two forms of sugars and enables cells to utilize them more efficiently for energy production and other metabolic processes.

There are several types of aldose-ketose isomerases, including:

1. Triose phosphate isomerase (TPI): This enzyme catalyzes the interconversion between dihydroxyacetone phosphate (a ketose) and D-glyceraldehyde 3-phosphate (an aldose), which are both trioses (three-carbon sugars). TPI plays a crucial role in glycolysis, the metabolic pathway that breaks down glucose to produce energy.
2. Xylulose kinase: This enzyme is involved in the pentose phosphate pathway, which is a metabolic route that generates reducing equivalents (NADPH) and pentoses for nucleic acid synthesis. Xylulose kinase catalyzes the conversion of D-xylulose (a ketose) to D-xylulose 5-phosphate, an important intermediate in the pentose phosphate pathway.
3. Ribulose-5-phosphate 3-epimerase: This enzyme is also part of the pentose phosphate pathway and catalyzes the interconversion between D-ribulose 5-phosphate (an aldose) and D-xylulose 5-phosphate (a ketose).
4. Phosphoglucomutase: This enzyme catalyzes the reversible conversion of glucose 1-phosphate (an aldose) to glucose 6-phosphate (an aldose), which is an important intermediate in both glycolysis and gluconeogenesis.
5. Phosphomannomutase: This enzyme catalyzes the reversible conversion of mannose 1-phosphate (a ketose) to mannose 6-phosphate (an aldose), which is involved in the biosynthesis of complex carbohydrates.

These are just a few examples of enzymes that catalyze the interconversion between aldoses and ketoses, highlighting their importance in various metabolic pathways.

Xylitol is a type of sugar alcohol used as a sugar substitute in various food and dental products. It has a sweet taste similar to sugar but with fewer calories and less impact on blood sugar levels, making it a popular choice for people with diabetes or those looking to reduce their sugar intake. Xylitol is also known to have dental benefits, as it can help prevent tooth decay by reducing the amount of bacteria in the mouth that cause cavities.

Medically speaking, xylitol is classified as a carbohydrate and has a chemical formula of C5H12O5. It occurs naturally in some fruits and vegetables, but most commercial xylitol is produced from corn cobs or other plant materials through a process called hydrogenation. While generally considered safe for human consumption, it can have a laxative effect in large amounts and may be harmful to dogs, so it's important to keep it out of reach of pets.

D-Xylulose Reductase is an enzyme that catalyzes the reduction of D-xylulose to xylitol using NADPH as a cofactor. This enzyme plays a role in the pentose phosphate pathway, which is a metabolic pathway that supplies reducing energy to cells by maintaining the level of the coenzyme NADPH. D-Xylulose Reductase is also involved in the metabolism of xylose, a type of sugar found in some fruits and vegetables, and is therefore of interest in the development of processes for the conversion of xylose to xylitol, a sweetener used in various food and pharmaceutical applications.

Uridine Diphosphate Xylose (UDP-Xylose) is not a medical term per se, but rather a biochemical term. It is the molecule that serves as the starting point for the biosynthesis of plant polysaccharides, such as xyloglucans and xylans, which are important components of the plant cell wall.

UDP-Xylose is a nucleotide sugar, meaning it consists of a sugar molecule (xylose) linked to a nucleotide (uridine diphosphate or UDP). It is synthesized in the cytoplasm of plant cells through the action of enzymes that transfer xylose from UDP-glucose to UTP.

In medicine, UDP-Xylose may be used as a substrate for enzyme assays or as a tool for studying carbohydrate metabolism in plants and microorganisms. However, it is not a substance that is typically used in medical treatments or interventions.

Fermentation is a metabolic process in which an organism converts carbohydrates into alcohol or organic acids using enzymes. In the absence of oxygen, certain bacteria, yeasts, and fungi convert sugars into carbon dioxide, hydrogen, and various end products, such as alcohol, lactic acid, or acetic acid. This process is commonly used in food production, such as in making bread, wine, and beer, as well as in industrial applications for the production of biofuels and chemicals.

Aldehyde reductase is an enzyme that belongs to the family of alcohol dehydrogenases. Its primary function is to catalyze the reduction of a wide variety of aldehydes into their corresponding alcohols, using NADPH as a cofactor. This enzyme plays a crucial role in the detoxification of aldehydes generated from various metabolic processes, such as lipid peroxidation and alcohol metabolism. It is widely distributed in different tissues, including the liver, kidney, and brain. In addition to its detoxifying function, aldehyde reductase has been implicated in several physiological and pathophysiological processes, such as neuroprotection, cancer, and diabetes.

Xylans are a type of complex carbohydrate, specifically a hemicellulose, that are found in the cell walls of many plants. They are made up of a backbone of beta-1,4-linked xylose sugar molecules and can be substituted with various side groups such as arabinose, glucuronic acid, and acetyl groups. Xylans are indigestible by humans, but they can be broken down by certain microorganisms in the gut through a process called fermentation, which can produce short-chain fatty acids that have beneficial effects on health.

Carbohydrate epimerases are a group of enzymes that catalyze the interconversion of specific stereoisomers (epimers) of carbohydrates by the reversible oxidation and reduction of carbon atoms, usually at the fourth or fifth position. These enzymes play important roles in the biosynthesis and modification of various carbohydrate-containing molecules, such as glycoproteins, proteoglycans, and glycolipids, which are involved in numerous biological processes including cell recognition, signaling, and adhesion.

The reaction catalyzed by carbohydrate epimerases involves the transfer of a hydrogen atom and a proton between two adjacent carbon atoms, leading to the formation of new stereochemical configurations at these positions. This process can result in the conversion of one epimer into another, thereby expanding the structural diversity of carbohydrates and their derivatives.

Carbohydrate epimerases are classified based on the type of substrate they act upon and the specific stereochemical changes they induce. Some examples include UDP-glucose 4-epimerase, which interconverts UDP-glucose and UDP-galactose; UDP-N-acetylglucosamine 2-epimerase, which converts UDP-N-acetylglucosamine to UDP-N-acetylmannosamine; and GDP-fucose synthase, which catalyzes the conversion of GDP-mannose to GDP-fucose.

Understanding the function and regulation of carbohydrate epimerases is crucial for elucidating their roles in various biological processes and developing strategies for targeting them in therapeutic interventions.

Arabinose is a simple sugar or monosaccharide that is a stereoisomer of xylose. It is a pentose, meaning it contains five carbon atoms, and is classified as a hexahydroxyhexital because it has six hydroxyl (-OH) groups attached to the carbon atoms. Arabinose is found in various plant polysaccharides, such as hemicelluloses, gums, and pectic substances. It can also be found in some bacteria and yeasts, where it plays a role in their metabolism. In humans, arabinose is not an essential nutrient and must be metabolized by specific enzymes if consumed.

Xylosidases are a group of enzymes that catalyze the hydrolysis of xylosides, which are glycosides with a xylose sugar. Specifically, they cleave the terminal β-1,4-linked D-xylopyranoside residues from various substrates such as xylooligosaccharides and xylan. These enzymes play an important role in the breakdown and metabolism of plant-derived polysaccharides, particularly hemicelluloses, which are a major component of plant biomass. Xylosidases have potential applications in various industrial processes, including biofuel production and animal feed manufacturing.

A pentose is a monosaccharide (simple sugar) that contains five carbon atoms. The name "pentose" comes from the Greek word "pente," meaning five, and "ose," meaning sugar. Pentoses play important roles in various biological processes, such as serving as building blocks for nucleic acids (DNA and RNA) and other biomolecules.

Some common pentoses include:

1. D-Ribose - A naturally occurring pentose found in ribonucleic acid (RNA), certain coenzymes, and energy-carrying molecules like adenosine triphosphate (ATP).
2. D-Deoxyribose - A pentose that lacks a hydroxyl (-OH) group on the 2' carbon atom, making it a key component of deoxyribonucleic acid (DNA).
3. Xylose - A naturally occurring pentose found in various plants and woody materials; it is used as a sweetener and food additive.
4. Arabinose - Another plant-derived pentose, arabinose can be found in various fruits, vegetables, and grains. It has potential applications in the production of biofuels and other bioproducts.
5. Lyxose - A less common pentose that can be found in some polysaccharides and glycoproteins.

Pentoses are typically less sweet than hexoses (six-carbon sugars) like glucose or fructose, but they still contribute to the overall sweetness of many foods and beverages.

Genetic engineering, also known as genetic modification, is a scientific process where the DNA or genetic material of an organism is manipulated to bring about a change in its characteristics. This is typically done by inserting specific genes into the organism's genome using various molecular biology techniques. These new genes may come from the same species (cisgenesis) or a different species (transgenesis). The goal is to produce a desired trait, such as resistance to pests, improved nutritional content, or increased productivity. It's widely used in research, medicine, and agriculture. However, it's important to note that the use of genetically engineered organisms can raise ethical, environmental, and health concerns.

Endo-1,4-beta Xylanases are a type of enzyme that catalyze the endohydrolysis of 1,4-beta-D-xylosidic linkages in xylans, which are complex polysaccharides made up of beta-1,4-linked xylose residues. Xylan is a major hemicellulose component found in the cell walls of plants, and endo-1,4-beta Xylanases play an important role in the breakdown and digestion of plant material by various organisms, including bacteria, fungi, and animals. These enzymes are widely used in industrial applications, such as biofuel production, food processing, and pulp and paper manufacturing, to break down xylans and improve the efficiency of various processes.

Cellobiose is a disaccharide made up of two molecules of glucose joined by a β-1,4-glycosidic bond. It is formed when cellulose or beta-glucans are hydrolyzed, and it can be further broken down into its component glucose molecules by the action of the enzyme beta-glucosidase. Cellobiose has a sweet taste, but it is not as sweet as sucrose (table sugar). It is used in some industrial processes and may have potential applications in the food industry.

Industrial microbiology is not strictly a medical definition, but it is a branch of microbiology that deals with the use of microorganisms for the production of various industrial and commercial products. In a broader sense, it can include the study of microorganisms that are involved in diseases of animals, humans, and plants, as well as those that are beneficial in industrial processes.

In the context of medical microbiology, industrial microbiology may involve the use of microorganisms to produce drugs, vaccines, or other therapeutic agents. For example, certain bacteria and yeasts are used to ferment sugars and produce antibiotics, while other microorganisms are used to create vaccines through a process called attenuation.

Industrial microbiology may also involve the study of microorganisms that can cause contamination in medical settings, such as hospitals or pharmaceutical manufacturing facilities. These microorganisms can cause infections and pose a risk to patients or workers, so it is important to understand their behavior and develop strategies for controlling their growth and spread.

Overall, industrial microbiology plays an important role in the development of new medical technologies and therapies, as well as in ensuring the safety and quality of medical products and environments.

"Zymomonas" is a genus of Gram-negative, facultatively anaerobic bacteria that are commonly found in sugar-rich environments such as fruit and flower nectar. The most well-known species in this genus is Zymomonas mobilis, which has attracted significant interest in the field of biofuels research due to its ability to efficiently ferment sugars into ethanol.

Zymomonas bacteria are unique in their metabolism and possess a number of unusual features, including a highly streamlined genome, a single polar flagellum for motility, and the ability to survive and grow at relatively high temperatures and ethanol concentrations. These characteristics make Zymomonas an attractive candidate for industrial applications, particularly in the production of biofuels and other bioproducts.

In addition to their potential industrial uses, Zymomonas bacteria have also been implicated in certain human diseases, particularly in individuals with weakened immune systems or underlying medical conditions. However, such cases are relatively rare, and the overall impact of Zymomonas on human health is still not well understood.

Ethanol is the medical term for pure alcohol, which is a colorless, clear, volatile, flammable liquid with a characteristic odor and burning taste. It is the type of alcohol that is found in alcoholic beverages and is produced by the fermentation of sugars by yeasts.

In the medical field, ethanol is used as an antiseptic and disinfectant, and it is also used as a solvent for various medicinal preparations. It has central nervous system depressant properties and is sometimes used as a sedative or to induce sleep. However, excessive consumption of ethanol can lead to alcohol intoxication, which can cause a range of negative health effects, including impaired judgment, coordination, and memory, as well as an increased risk of accidents, injuries, and chronic diseases such as liver disease and addiction.

Glucose is a simple monosaccharide (or single sugar) that serves as the primary source of energy for living organisms. It's a fundamental molecule in biology, often referred to as "dextrose" or "grape sugar." Glucose has the molecular formula C6H12O6 and is vital to the functioning of cells, especially those in the brain and nervous system.

In the body, glucose is derived from the digestion of carbohydrates in food, and it's transported around the body via the bloodstream to cells where it can be used for energy. Cells convert glucose into a usable form through a process called cellular respiration, which involves a series of metabolic reactions that generate adenosine triphosphate (ATP)—the main currency of energy in cells.

Glucose is also stored in the liver and muscles as glycogen, a polysaccharide (multiple sugar) that can be broken down back into glucose when needed for energy between meals or during physical activity. Maintaining appropriate blood glucose levels is crucial for overall health, and imbalances can lead to conditions such as diabetes mellitus.

Xylan Endo-1,3-beta-Xylosidase is an enzyme that breaks down xylan, which is a major component of hemicellulose in plant cell walls. This enzyme specifically catalyzes the hydrolysis of 1,3-beta-D-xylosidic linkages in xylans, resulting in the release of xylose units from the xylan backbone. It is involved in the process of breaking down plant material for various industrial applications and in the natural decomposition of plants by microorganisms.

Carbohydrate metabolism is the process by which the body breaks down carbohydrates into glucose, which is then used for energy or stored in the liver and muscles as glycogen. This process involves several enzymes and chemical reactions that convert carbohydrates from food into glucose, fructose, or galactose, which are then absorbed into the bloodstream and transported to cells throughout the body.

The hormones insulin and glucagon regulate carbohydrate metabolism by controlling the uptake and storage of glucose in cells. Insulin is released from the pancreas when blood sugar levels are high, such as after a meal, and promotes the uptake and storage of glucose in cells. Glucagon, on the other hand, is released when blood sugar levels are low and signals the liver to convert stored glycogen back into glucose and release it into the bloodstream.

Disorders of carbohydrate metabolism can result from genetic defects or acquired conditions that affect the enzymes or hormones involved in this process. Examples include diabetes, hypoglycemia, and galactosemia. Proper management of these disorders typically involves dietary modifications, medication, and regular monitoring of blood sugar levels.

Catabolite repression is a process that regulates the metabolism of carbohydrates in bacteria. It is a mechanism by which bacteria prioritize the use of different sugars as a source of energy and carbon. When glucose or other easily metabolized sugars are available, bacteria will preferentially use them for energy production and will suppress the expression of genes involved in the metabolism of less-preferred sugars. This is achieved through the regulation of gene expression by catabolic repression proteins, such as cAMP receptor protein (CRP) and catabolite control protein A (CcpA). These proteins bind to specific DNA sequences called promoters and repress the transcription of genes involved in the metabolism of less-preferred sugars. This allows the bacteria to efficiently use their resources and adapt to changing environmental conditions.

'Candida' is a type of fungus (a form of yeast) that is commonly found on the skin and inside the body, including in the mouth, throat, gut, and vagina, in small amounts. It is a part of the normal microbiota and usually does not cause any problems. However, an overgrowth of Candida can lead to infections known as candidiasis or thrush. Common sites for these infections include the skin, mouth, throat, and genital areas. Some factors that can contribute to Candida overgrowth are a weakened immune system, certain medications (such as antibiotics and corticosteroids), diabetes, pregnancy, poor oral hygiene, and wearing damp or tight-fitting clothing. Common symptoms of candidiasis include itching, redness, pain, and discharge. Treatment typically involves antifungal medication, either topical or oral, depending on the site and severity of the infection.

Polysaccharides are complex carbohydrates consisting of long chains of monosaccharide units (simple sugars) bonded together by glycosidic linkages. They can be classified based on the type of monosaccharides and the nature of the bonds that connect them.

Polysaccharides have various functions in living organisms. For example, starch and glycogen serve as energy storage molecules in plants and animals, respectively. Cellulose provides structural support in plants, while chitin is a key component of fungal cell walls and arthropod exoskeletons.

Some polysaccharides also have important roles in the human body, such as being part of the extracellular matrix (e.g., hyaluronic acid) or acting as blood group antigens (e.g., ABO blood group substances).

Ribose is a simple carbohydrate, specifically a monosaccharide, which means it is a single sugar unit. It is a type of sugar known as a pentose, containing five carbon atoms. Ribose is a vital component of ribonucleic acid (RNA), one of the essential molecules in all living cells, involved in the process of transcribing and translating genetic information from DNA to proteins. The term "ribose" can also refer to any sugar alcohol derived from it, such as D-ribose or Ribitol.

Metabolic engineering is a branch of biotechnology that involves the modification and manipulation of metabolic pathways in organisms to enhance their production of specific metabolites or to alter their flow of energy and carbon. This field combines principles from genetics, molecular biology, biochemistry, and chemical engineering to design and construct novel metabolic pathways or modify existing ones with the goal of optimizing the production of valuable compounds or improving the properties of organisms for various applications.

Examples of metabolic engineering include the modification of microorganisms to produce biofuels, pharmaceuticals, or industrial chemicals; the enhancement of crop yields and nutritional value in agriculture; and the development of novel bioremediation strategies for environmental pollution control. The ultimate goal of metabolic engineering is to create organisms that can efficiently and sustainably produce valuable products while minimizing waste and reducing the impact on the environment.

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