*  Criminality in men with Klinefelter's syndrome and XYY syndrome: a cohort study | BMJ Open
Using the Danish Cytogenetic Central Register, we identified all men diagnosed with a karyotype compatible with KS, 47,XYY or ... Prison survey for the XYY karyotype in tall inmates. Behav Genet 1973;3:97-100. ... Persons with 47,XYY. In total, the risk of convictions was moderately increased in persons with 47,XYY compared to controls (HR ... Long-term follow-up of a cohort of KS (n=19) and 47,XYY (n=19) indicated that persons with 47,XYY had a fourfold increase in ...
  http://bmjopen.bmj.com/content/2/1/e000650
*  X/XY/XYY mosaicism as a cause of subfertility in boars: a single case study - Kent Academic Repository
Cytogenetic analysis of fibroblasts confirmed this mosaic karyotype with similar percentages of cell lines observed 39,XYY[76]/ ... Quilter, Claire R and Wood, D. and Southwood, O.I. and Griffin, Darren K. (2003) X/XY/XYY mosaicism as a cause of subfertility ... X/XY/XYY mosaicism as a cause of subfertility in boars: a single case study ... It is of particular interest that this karyotype is associated with reduced boar fertility, which could lead to potential ...
  https://kar.kent.ac.uk/12481/
*  Are XYY males more prone to aggressive behavior than XY males
XYY karyotype, 47, XYY syndrome, diplo-Y syndrome, polysomy Y, YY syndrome). The 47, XYY chromosome karyotype is the result of ... The XYY Genotype.' Annual Review of Medicine 29 (1978): 563-70. Witkin, H. A., et al. 'Criminality in XYY andXXY Men.' Science ... The debate about the XYY karyotype can be seen as part of the old debate about nature and nurture. The belief that nature, or ... According to Theilgaard, the frequency of men with the XYY karyotype (the number, types, and forms of chromosomes in a cell) is ...
  http://www.scienceclarified.com/dispute/Vol-1/Are-XYY-males-more-prone-to-aggressive-behavior-than-XY-males.html
*  X-chromosome Inactivation, Epigenetics and the Transcriptome - Full Text View - ClinicalTrials.gov
XYY Karyotype. Disease. Pathologic Processes. Vascular Diseases. Cardiovascular Diseases. Aortic Diseases. Disorders of Sex ... Genetic and Rare Diseases Information Center resources: Turner Syndrome Gonadal Dysgenesis 47, XYY Syndrome 47 XXX Syndrome ... Genetics Home Reference related topics: 47,XYY syndrome Klinefelter syndrome Turner syndrome triple X syndrome ... Turner Syndrome Klinefelter Syndrome Triple X Syndrome 47 XYY Syndrome Aortic Aneurysm ...
  https://clinicaltrials.gov/ct2/show/NCT01678261?recr=Open&cond=%22Klinefelter+Syndrome%22&rank=4
*  XYY syndrome - Wikipedia
XYY karyotype. The incidence of 47,XYY is not known to be affected by the parents' ages. In April 1956, Hereditas published the ... XYY karyotype, and mischaracterized them as aggressive and violent criminals. Over the next decade, almost all published XYY ... XYY and are managed no differently from in 46,XY males. Aggression is not seen more frequently in 47,XYY males. 47,XYY is not ... XYY. Testosterone levels (prenatally) are normal in 47,XYY males. Most 47,XYY males have normal sexual development and have ...
  https://en.wikipedia.org/wiki/XYY_syndrome
*  Health Library - North Kansas City Hospital, Kansas City, MO
XYY karyotype National Organization for Rare Disorders * XYY Syndrome National Organization for Rare Disorders ...
  http://www.nkch.org/patients-visitors/health-library/?prefix=X
*  karyotype - ?? ??? ????, ?? ??, ???? ?? OK
Q98.5 ???? 47, XYY(Karyotype 47, XYY) Q98.6 ???? ???? ?ü? ?? (Male with structurally abnormal sex chromosome) Q98.7 ü ... karyotype ۣ뢥 ??ӣ????? ???? [??Ű] ???? Karyotype [??] ???? м ( ?? ) karyotype analysis [??] ???? ( ) karyotype [??] Karyotype ... Q96.1 ???? 46, X ??????(Xq)(Karyotype 46, X iso(Xq)) Q96.2 ????(Xq) ?? ?? ???? ?ü? ?? ???? 46,X(Karyotype 46,X with abnormal ... karyotype. ٸ ???? ã ??̹???? ?? ??? Cambridge M-W M-W Thesaurus OneLook Wordnet Google. ...
  http://dic.impact.pe.kr/ecmaster-cgi/search.cgi?kwd=karyotype
*  XYY syndrome - Biology-Online Dictionary
Thus, males with XYY syndrome would have 47 chromosomes and a 47, XYY karyotype. One possible cause could be traced back to a ... 1 Robinson, D. O. and Jacobs, P. A. (November 1, 1999). "The origin of the extra Y chromosome in males with a 47,XYY karyotype ... XYY syndrome is a genetic condition in which the male is born with an extra Y chromosome. ... Some of the common symptoms with XYY syndrome include being exceptionally tall, (about 6 ft or taller), prone to acne, and ...
  https://www.biology-online.org/dictionary/Jacobs_syndrome
*  Double Y syndrome - RightDiagnosis.com
47 XYY syndrome) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and ... Double Y syndrome: genetic disorder that produces tall and in many cases disturbed behavioral males due to XYY karyotype. ... 47 XYY syndrome: »Introduction: 47 XYY syndrome »Symptoms of 47 XYY syndrome ... Introduction: 47 XYY syndrome »Symptoms of 47 XYY syndrome Double Y syndrome: Related Diseases. Double Y syndrome: Double Y ...
  http://www.rightdiagnosis.com/medical/double_y_syndrome.htm
*  Case Reports - Reviews sub-cluster 37
A 5 10/12 year-old boy with a 47,XYY karyotype, micropenis, scrotal hypospadias and right testicular regression is described. ...
  http://www.biomedsearch.com/cluster/53/Case-Reports-Reviews/sub-37-p8.html
*  What Does It Mean When Your Baby Is Born With An Extra Chromosome?
Boys with XYY syndrome can lead a normal life. Sometimes the abnormality goes undetected. Also called XYY Karyotype or Jacob's ...
  http://www.momjunction.com/articles/baby-is-born-with-an-extra-chromosome_00118040/
*  Klinefelter Syndrome Differential Diagnoses
XYY karyotypes. Birth Defects Orig Artic Ser. 1979. 15(1):261-6. [Medline]. ... Lahlou N, Fennoy I, Ross JL, Bouvattier C, Roger M. Clinical and hormonal status of infants with nonmosaic XXY karyotype. Acta ... Aboulghar H, Aboulghar M, Mansour R, Serour G, Amin Y, Al-Inany H. A prospective controlled study of karyotyping for 430 ... These include Kallmann syndrome and 46,XX karyotype (in males). The 46,XX male is caused by translocation of Y material ( ...
  https://emedicine.medscape.com/article/945649-differential
*  PPT - Mitosis and Meiosis PowerPoint presentation | free to download - id: 6c69a-OGFhM
Down syndrome karyotype. Figure 8.20Ax 100*Klinefelters karyotype Figure 8.22Ax 101*XYY karyotype ... Human female karyotype. Figure 8.19x2 14. Packaging of Genetic Materialhttp//www.biostudio. .com/demo_freeman_dna_coiling.htm* ...
  http://www.powershow.com/view/6c69a-OGFhM/Mitosis_and_Meiosis_powerpoint_ppt_presentation
*  History - It's In The Genes - tribunedigital-orlandosentinel
... although many studies have failed to show any relationship between criminality and the XYY karyotype. ... He had many characteristics of a chromosomal abnormality, such as 47,XYY syndrome. The disorder - caused by an extra copy of ...
  http://articles.orlandosentinel.com/1994-06-05/entertainment/9406030350_1_y-chromosome-genetic-disorders-marion
*  Male Infertility Natural male infertility solutions traditional fertility
XYY male: An XYY karyotype is observed in 0.1-0.4% of newborn males. These patients are often tall and severely oligospermic or ... Karyotype shows a normal SRY gene. Patients may achieve normal virilization and adult phenotype by the administration of ... XX male (sex reversal syndrome): An XX karyotype is due to a crossover of the sex-determining region (SRY) of the Y chromosome ... Functional sperm that are present may have a normal karyotype.. * Noonan syndrome (46, XY): Patients with Noonan syndrome, also ...
  http://taseerlabs.com/MaleInfertility/maleinfertility.html
*  Found Deceased IN - Abigail Williams, 13, & Liberty German, 14, Delphi, 13 Feb 2017 #37 - Page 52
... born in Copenhagen from 1944 1947 for XXY and XYY karyotypes, and found an increased rate of minor criminal convictions for ... XYY and are managed no differently from in 46,XY males. Aggression is not seen more frequently in 47,XYY males.. And this:. In ... XYY and are managed no differently from in 46,XY males. Aggression is not seen more frequently in 47,XYY males.. And this:. In ... born in Copenhagen from 1944-1947 for XXY and XYY karyotypes, and found an increased rate of minor criminal convictions for ...
  http://www.websleuths.com/forums/showthread.php?333246-IN-Abigail-Williams-13-amp-Liberty-German-14-Delphi-13-Feb-2017-37&p=13256510
*  Mosaic double aneuploidy: Down syndrome and XYY.
The karyotype was 47, XY,+21[19]/48, XYY,+21[6]. ish XYY (DXZ1 × 1, DYZ1 × 2). Mosaic double aneuploidies are very rare and ... Cytogenetic analysis showed a mosaicism for a double aneuploidy, Down syndrome and XYY. ...
  http://www.biomedsearch.com/nih/Mosaic-double-aneuploidy-Down-syndrome/24339550.html
*  Sex chromosome anomalies
XXXY karyotype (Klinefelter syndrome) and the other with a 47,XYY karyotype (Jacob syndrome). In both patients, the ... ... Karyotypes show the number, size, and shape of the chromosomes in the individual's cells. A karyotype can be created by using a ... All sex chromosome anomaly syndromes can be diagnosed with a chromosome analysis, called a karyotype. ... and XYY syndrome. Features of sex chromosome anomaly syndromes vary and depend on the specific syndrome. In general, sex ...
  http://diseaseinfosearch.org/Sex+chromosome+anomalies/6533
*  Avery Sandberg - Wikipedia
XYY karyotype in 1961. The Y Chromosome, Part B: Clinical Aspects of Y Chromosome Abnormalities (1985) ISBN 0-471-84767-4 The ...
  https://en.wikipedia.org/wiki/Avery_Sandberg
*  Gestational Trophoblastic Disease Treatment (PDQ®): Treatment - Health Professional Information [NCI] - WellSpan Health Library
... the possible resulting triploid karyotypes are 69 XXY, 69 XXX, or 69 XYY. Therefore, in contrast to a complete mole, the ... resulting in either case in a diploid karyotype. The former case always yields a mole with a karyotype of 46 XX, since at least ... The latter case may yield a karyotype of 46 XX or 46 XY. About 90% of complete HMs are 46 XX. On ultrasound examination, ... Most choriocarcinomas have an aneuploid karyotype, and about three-quarters of them contain a Y chromosome. Most follow an HM ...
  http://www.wellspan.org/health-library/Document.aspx?id=ncicdr0000062901
*  QualiCell® Mouse Embryonic Stem Cell-XLC271 | Creative Bioarray
Karyotype. 40,XYY,-10[1]/41,XYY[1]/40,XY[23]. Source ... Molecular Karyotyping (aCGH). *In Situ Detection of CAR-T Cells ...
  https://www.creative-bioarray.com/QualiCell%C2%AE-Mouse-Embryonic-Stem-Cell-XLC271-CSC-C00212-item-2835.htm


(1/26) Evaluation of antecedent stimulus parameters for the treatment of escape-maintained aberrant behavior.

We evaluated a methodology for identifying the range of stimulus features of antecedent stimuli associated with aberrant behavior in demand contexts in natural settings. For each participant, an experimental analysis of antecedents (Phase 1) was conducted to confirm the hypothesis that task instructions occasioned increases in aberrant behavior. During Phase 2, specific stimulus features associated with the presentation of task instructions were assessed by evaluating the child's behavior across two distinct settings, therapists, and types of tasks in a sequential fashion. Aberrant behavior occurred immediately across settings and therapists, presumably because the presence of a discriminative stimulus for escape-maintained behavior (the delivery of a task instruction) occasioned aberrant behavior. However, aberrant behavior decreased initially across tasks, suggesting that familiarity with the task might be a variable. During Phase 3, an experimental (functional) analysis of consequences was conducted with 2 participants to verify that aberrant behavior was maintained by negative reinforcement. During Phase 4, a treatment package that interspersed play with task instructions was conducted to disrupt the ongoing occurrence of aberrant behavior. Immediate and durable treatment effects occurred for 2 of the 3 participants.  (+info)

(2/26) Fluorescence in-situ hybridization analysis of chromosomal constitution in spermatozoa from a mosaic 47,XYY/46,XY male.

Sex-chromosome mosaicism in spermatozoa from a mosaic 47,XYY[20%]/46, XY[80%] male with fertility problems was assessed using triple-probe fluorescence in-situ hybridization (FISH) studies. Chromosome-specific probes for X, Y and 18 were used, and the possible outcomes were deduced. In normal haploid spermatozoa of the patient and a normal 46,XY male control, the X:Y ratio was close to 1:1. There was a significant difference in the total incidence of karyotypically abnormal spermatozoa between the patient and the 46, XY male control (2.31% versus 1.46%, P < 0.0001). The incidence of some types of disomic spermatozoa X+Y+18 (24,XY) and X+18+18 (24,X, +18), or diploid X+Y+18+18 (46,XY) spermatozoa was significantly increased in the patient's semen sample. There was, however, no significant difference in the incidence of disomic Y+Y+18 (24,YY) spermatozoa. Because the majority of the patient's spermatozoa was karyotypically normal, the aetiology of his fertility problems was unclear. These results add to the growing body of information regarding chromosome abnormalities in spermatozoa from men who are mosaic for sex chromosome abnormalities. In these men, FISH analysis of spermatozoa may be warranted to determine the relative percentages of abnormal cells, and to determine if in-vitro fertilization with preimplantation genetic diagnosis may increase the likelihood of a successful pregnancy.  (+info)

(3/26) Abnormal children of a 47,XYY father.

Abnormal children of two 47,XYY men were studied. One of these men had 2 normal daughters and a child, 45,X/46,XY, with gonadal dysgenesis. The other man had 2 normal sons and a child with Down's syndrome. The extra chromosome 21 of this child came from the mother. Another 47,XYY man had 4 normal children.  (+info)

(4/26) Chromosome constitution and apoptosis of immature germ cells present in sperm of two 47,XYY infertile males.

BACKGROUND: In order to assess sperm alterations observed in some XYY males, we analysed the chromosome constitution as well as apoptosis expression in germ cells from two oligozoospermic males with high count of immature germ cells in their semen. METHODS: Sex chromosome number and distribution were assessed at pachytene stage by fluorescence in situ hybridization (FISH). Immature germ cells and spermatozoa were examined by FISH and TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end (TUNEL) assay, combined with immunocytochemistry using the proacrosin-specific monoclonal antibody (mAb 4D4). RESULTS: For patients 1 and 2, two Y chromosomes were present in respectively 60.0 and 39.6% of pachytenes. The three sex chromosomes were always in close proximity and partially or totally condensed in a sex body. XYY spermatocytes I escape the pachytene checkpoint and achieve meiosis. Nevertheless, nuclear division and/or cytokinesis were often impaired during meiosis leading to diploid (mainly 47,XYY cells) and tetraploid (94,XXYYYY) meiocytes. The presence of binucleated (23,Y)(24,XY) immature germ cells resulting from cytokinesis failure agree with a preferential segregation of the two Y chromosomes during meiosis I. In addition, 69.6% (patient 1) and 53.12% (patient 2) of post-reductional round germ cells were XY. However, high level of apoptotic round germ cells (94.9% for patient 1 and 93.3% for patient 2) was detected and may explain the moderate increase of hyperhaploid XY spermatozoa. Segregation errors also occurred in the XY cell line responsible for disomic 18 and X, as well as 46,XY diploid spermatozoa. CONCLUSIONS: Our data are in agreement with the persistence of the extra Y chromosome during meiosis in XYY oligozoospermic males responsible for spermatogenesis impairment and a probable elimination via apoptosis of most XYY germ cells not solely during but also after meiosis.  (+info)

(5/26) Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids.

Transcriptional silencing of the sex chromosomes during male meiosis (MSCI) is conserved among organisms with limited sex chromosome synapsis, including mammals. Since the 1990s the prevailing view has been that MSCI in mammals is transient, with sex chromosome reactivation occurring as cells exit meiosis. Recently, we found that any chromosome region unsynapsed during pachytene of male and female mouse meiosis is subject to transcriptional silencing (MSUC), and we hypothesized that MSCI is an inevitable consequence of this more general meiotic silencing mechanism. Here, we provide direct evidence that asynapsis does indeed drive MSCI. We also show that a substantial degree of transcriptional repression of the sex chromosomes is retained postmeiotically, and we provide evidence that this postmeiotic repression is a downstream consequence of MSCI/MSUC. While this postmeiotic repression occurs after the loss of MSUC-related proteins at the end of prophase, other histone modifications associated with transcriptional repression have by then become established.  (+info)

(6/26) Genetic and epigenetic risks of intracytoplasmic sperm injection method.

Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection (ICSI) procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent that consequences of the genetic abnormalities underlying male subfertility (or infertility) and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.  (+info)

(7/26) Frequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Thai men with oligozoospermia and azoospermia.

AIM: To investigate the possible causes of oligozoospermia and azoospermia in infertile Thai men, and to find the frequencies of Y chromosome microdeletions and cytogenetic abnormalities in this group. METHODS: From June 2003 to November 2005, 50 azoospermic and 80 oligozoospermic men were enrolled in the study. A detailed history was taken for each man, followed by general and genital examinations. Y chromosome microdeletions were detected by multiplex polymerase chain reaction (PCR) using 11 gene-specific primers that covered all three regions of the azoospermic factor (AZFa, AZFb and AZFc). Fifty men with normal semen analysis were also studied. Karyotyping was done with the standard G- and Q-banding. Serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and testosterone were measured by electrochemiluminescence immunoassays (ECLIA). RESULTS: Azoospermia and oligozoospermia could be explained by previous orchitis in 22.3%, former bilateral cryptorchidism in 19.2%, abnormal karyotypes in 4.6% and Y chromosome microdeletions in 3.8% of the subjects. The most frequent deletions were in the AZFc region (50%), followed by AZFb (33%) and AZFbc (17%). No significant difference was detected in hormonal profiles of infertile men, with or without microdeletions. CONCLUSION: The frequencies of Y chromosome microdeletions and cytogenetic abnormalities in oligozoospermic and azoospermic Thai men are comparable with similarly infertile men from other Asian and Western countries.  (+info)

(8/26) A dispermic chimera with mixed field blood group B and mosaic 46,XY/47,XYY karyotype.

Chimerism in humans is a rare phenomenon often initially identified in the resolution of an ABO blood type discrepancy. We report a dispermic chimera who presented with mixed field in his B antigen typing that might have been mistaken for the B3 subtype. The propositus is a healthy Korean male blood donor. Neither his clinical history nor initial molecular investigation of his ABO gene explained his mixed field agglutination with murine anti-B. Chimerism was suspected, and 9 short tandem repeat (STR) loci were analyzed on DNA extracted from blood, buccal swabs, and hair from this donor and on DNA isolated from peripheral blood lymphocytes from his parents. The propositus' red blood cells demonstrated mixed field agglutination with anti-B. Exon 6 and 7 and flanking intronic regions of his ABO gene were sequenced and revealed an O01/O02 genotype. B allele haplotype-specific PCR, along with exon 6 and 7 cloning and sequencing demonstrated a third ABO allele, B101. Four STR loci demonstrated a pattern consistent with a double paternal chromosome contribution in the propositus, thus confirming chimerism. His karyotype revealed a mosaic pattern: 32/50 metaphases were 46,XY and 18/50 metaphases demonstrated 47,XYY.  (+info)