*  Vesiculovirus matrix (IPR009397) | InterPro | EMBL-EBI

This family consists of several Vesiculovirus matrix proteins. The matrix (M) protein of vesicular stomatitis virus (VSV) ...

*  Vesiculovirus - Wikipedia

Vesiculovirus is a genus of negative-sense ssRNA viruses in the family Rhabdoviridae, within the order Mononegavirales. Table ...

*  Vesiculovirus matrix proteins - Wikipedia

The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known ...

*  Structural intermediates in the fusion‐associated transition of vesiculovirus glycoprotein | The EMBO Journal

Structural intermediates in the fusion‐associated transition of vesiculovirus glycoprotein. Eduard Baquero, Aurélie A Albertini ... Structural determination of two intermediate conformations of a vesiculovirus glycoprotein reveals the chronological order of ...

*  Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses, Book by Andrew MQ King (Other) | chapters...

Vesiculovirus. Genus. Lyssavirus. Genus. Ephemerovirus. Genus. Novirhabdovirus. Genus. Cytorhabdovirus. Genus. ...

*  Marine Drugs | Free Full-Text | Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae | HTML

Vesiculovirus/Rhabdoviridae. HEL. 20, 200 (exocellular extracts); 12-56; 20-45. [48,49,50,51]. ...

*  Gonococcal stomatitis - definition of gonococcal stomatitis by The Free Dictionary

vesicular stomatitis - a disease of horses, cattle, swine, and occasionally human beings; caused by the vesiculovirus ...

*  Academic Programs Faculty - Last Initial L - Wake Forest School of Medicine

Vesicular stomatitis Indiana virus; Viral Matrix Proteins; Vesiculovirus; Apoptosis; Virus Replication Department: 336-716-4237 ...

*  Lutzomyia - Wikipedia

One such virus of medical importance is the vesicular stomatitis virus (VSV) of the Vesiculovirus genus. Viruses of this genus ...

*  Rhabdoviridae infections | definition of Rhabdoviridae infections by Medical dictionary

Two genera cause disease in animals: Vesiculovirus, which contains vesicular stomatitis virus, Lyssavirus, which contains ... Five genera have been found: Vesiculovirus, Lyssavirus, Ephemerovirus, Nucleorhabdovirus, and Cytorhabdovirus.. Rhabdoviridae. ... including the genera Vesiculovirus and Lyssavirus.. Rhab·do·vir·i·dae (rab'dō-vir'i-dē) A family of rod-shaped or bullet-shaped ...

*  Patent US7384738 - Retrovirus-based genomic screening - Google Patents

The G proteins of viruses in the Vesiculovirus genera have a covalently bound palmititic acid (C16) moiety. The amino acid ... 5,512,421, which is incorporated herein by reference). The G proteins of viruses in the Vesiculovirus genera other than VSV, ... The Rhabdoviridae family encompasses the genus Vesiculovirus, which includes vesicular stomatitis virus (VSV), Cocal virus, ... The G proteins of viruses in the Vesiculovirus genera are virally-encoded integral membrane proteins that form externally ...

*  Chandipura virus - Wikipedia

Basak, S.; Mondal, A.; Polley, S.; Mukhopadhyay, S.; Chattopadhyay, D. (October 2007). "Reviewing Chandipura: A Vesiculovirus ...

*  Rhabdoviridae - Wikipedia

An unofficial supergroup - "Dimarhabdovirus" - refers to the genera Ephemerovirus and Vesiculovirus. A number of other viruses ... Vesiculovirus, Perhabdovirus, Sigmavirus, Ephemerovirus, Tibrovirus, Tupavirus and Sprivivirus' - which were previously ...

*  Vesicular stomatitis virus - Wikipedia

ViralZone: Vesiculovirus Vesicular Stomatitis Virus from The Lab-On-Site Project. Disease card on World Organisation for Animal ... Vesiculovirus matrix proteins Viral neuronal tracing VSV-EBOV "Vesicular Stomatitis Virus". reviewed and published by WikiVet, ... Vesicular stomatitis Indiana virus (VSIV) is the prototypic member of the genus Vesiculovirus of the family Rhabdoviridae. VSIV ...

*  La Biblioteca de MaverickLibros de VeterinariaVeterinary Books: 05-feb-2009

Vesiculovirus-based candidate vaccines.. 15.8. Respirovirus-based candidate vaccines. 15.9. Subunit candidate vaccines. 15.10. ...

*  Veterinary virology - Wikipedia

Novirhabdoviruses infect fish, and vesiculovirus, lyssavirus and ephemerovirus infect mammals, fish and invertebrates. The ...

*  Brevet US20060000776 - Hollow fiber contactor systems for removal of lipids from fluids - Google Brevets

Vesiculovirus (vesiculoviruses), Lyssavirus (lyssaviruses), Ephemerovirus (ephemeroviruses), Cytorhabdovirus (plant rhabdovirus ...

*  Identification of rhabdoviral sequences in oropharyngeal swabs from German and Danish bats | Virology Journal | Full Text

Distinct lineage of vesiculovirus from big brown bats, United States. Emerg Infect Dis 2013, 19: 1978-1980. doi:10.3201/ ...

*  The EMBO Journal Table of Contents for 01 March 2017; Vol. 36, No. 5

Structural intermediates in the fusion‐associated transition of vesiculovirus glycoprotein. Distinct conformations of ...

*  US Patent # 9,566,348. Methods and compositions for the treatment of cancer and infectious disease using alpha(2)...

... including the genus Vesiculovirus (VSV), Chandipura virus, Flanders-Hart Park virus), the genus Lyssavirus (Rabies virus), fish ...

*  Soumen Basak | NII

A vesiculovirus in human epidemics. Bioscience Reports, 27(4-5): 275-98, Oct 2007. ...

*  IRRADIATED BIODEGRADABLE POLYMER MICROPARTICLES - Patent application

0151] Viral antigens may be derived from a Rhabdovirus, such as a Lyssavirus (Rabies virus) and Vesiculovirus (VSV). ...

*  Systematic Bacteriology and Virology: Rhabdoviruses

It has two genera-Vesiculovirus, which causes vesicular stomatitis in horses, cattle and pigs,rarely infects humans & ...

*  中国科学院水生生物研究所机构知识库(IHB OpenIR): Isolation and characterization of Scophthalmus

... although it is closely related to rhabdoviruses in the genus Vesiculovirus. ... although it is closely related to rhabdoviruses in the genus Vesiculovirus. ...

*  Taxonomic list of viruses - Wikipedia

Vesiculovirus Carajas virus Chandipura virus Cocal virus Isfahan virus Maraba virus Piry virus Vesicular stomatitis Alagoas ...

(1/449) Re-emergence of vesicular stomatitis in the western United States is associated with distinct viral genetic lineages.

Phylogenetic analysis of partial phosphoprotein and glycoprotein gene sequences showed that a single genetic lineage of vesicular stomatitis virus (VSV) serotype New Jersey (NJ) caused the 1995 and 1997 outbreaks of vesicular stomatitis (VS) in the western United States. While distinct from VSV-NJ strains causing previous outbreaks in the western United States and those circulating in feral swine in the southeastern United States, this lineage was closely related to viral lineages circulating in the Mexican states of Guerrero, Veracruz, and Oaxaca in 1996, 1989, and 1984 respectively. In 1997 and 1998, VSV serotype Indiana 1 (IN1) re-emerged in the western United States after 30 years. Viruses causing these outbreaks grouped within a single genetic lineage distinct from VSV-IN1 isolates causing outbreaks in the western United States in 1929 and 1956 but closely related to a strain circulating in the state of Colima in central Mexico in 1997. Our data showed that sporadic VS outbreaks in the western United States are caused by genetically distinct viral lineages closer to those circulating in enzootic areas of central and southern Mexico than to those causing previous outbreaks in the United States. The genetic evidence and temporal distribution of outbreaks are not consistent with a pattern of long-term maintenance of VSV in the western United States.  (+info)

(2/449) N-terminal region of P protein of Chandipura virus is responsible for phosphorylation-mediated homodimerization.

The phosphoprotein P of Chandipura (CHP) virus, an Indian isolate of rhabdovirus, was found to support transcription upon phosphorylation by casein kinase II (CKII). A phosphorylation-induced change in the protein conformation was found to occur at the N-terminal region of the protein. Biochemical studies for further characterization of this phosphorylation-based conformational alteration demonstrated that phosphorylation leads to the transition from an 'open' to 'closed' structure of the protein. The phosphate group introduced by CKII was found to be resistant to phosphatases. This phosphorylation-based structural alteration changes the accessible hydrophobic surface area of the protein and also the available digestion sites of different proteases. The phosphorylated form of P protein was found to be a dimer by His-tag dilution assay. Using the same approach it was found that the N-terminal 46 amino acids are responsible for P-P dimerization, only after phosphorylation.  (+info)

(3/449) Glycoprotein exchange vectors based on vesicular stomatitis virus allow effective boosting and generation of neutralizing antibodies to a primary isolate of human immunodeficiency virus type 1.

Live recombinant vesicular stomatitis viruses (VSVs) expressing foreign antigens are highly effective vaccine vectors. However, these vectors induce high-titer neutralizing antibody directed at the single VSV glycoprotein (G), and this antibody alone can prevent reinfection and boosting with the same vector. To determine if efficient boosting could be achieved by changing the G protein of the vector, we have developed two new recombinant VSV vectors based on the VSV Indiana serotype but with the G protein gene replaced with G genes from two other VSV serotypes, New Jersey and Chandipura. These G protein exchange vectors grew to titers equivalent to wild-type VSV and induced similar neutralizing titers to themselves but no cross-neutralizing antibodies to the other two serotypes. The effectiveness of these recombinant VSV vectors was illustrated in experiments in which sequential boosting of mice with the three vectors, all encoding the same primary human immunodeficiency virus (HIV) envelope protein, gave a fourfold increase in antibody titer to an oligomeric HIV envelope compared with the response in animals receiving the same vector three times. In addition, only the animals boosted with the exchange vectors produced antibodies neutralizing the autologous HIV primary isolate. These VSV envelope exchange vectors have potential as vaccines in immunizations when boosting of immune responses may be essential.  (+info)

(4/449) Development of an immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay for detection of equine and swine IgM antibodies to vesicular stomatitis virus.

An immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (MC-ELISA) was developed for the detection of primary infection of vesicular stomatitis virus (VSV) in equine and swine sera. The test was based on the use of biotinylated sheep antibodies against equine or swine IgM molecules bound to a streptavidin-coated ELISA plate. The captured IgM antibodies were detected by application of antigens prepared from the New Jersey and the Indiana VSV serotypes (VSV-NJ and VSV-IN, respectively) and mouse polyclonal antibodies against VSV-NJ and VSV-IN. The MC-ELISA was compared to a competitive ELISA (C-ELISA) and the standard microtiter serum neutralization (MTSN) assay by testing serum samples from horses and pigs experimentally infected with VSV-NJ or VSV-IN. The MC-ELISA detected specific homologous IgM antibodies from equine and swine sera as early as 5 and 4 days postinfection (DPI), respectively, and as late as 35 DPI. The MTSN test also detected antibodies as early as 5 DPI and as late as 160 DPI. In a similar fashion, the C-ELISA detected antibodies from 6 to 7 DPI and as late as 160 DPI. These results demonstrated that the MC-ELISA is a useful test for serodiagnosis of primary VSV infection in horses and pigs.  (+info)

(5/449) Multiple vesiculoviral matrix proteins inhibit both nuclear export and import.

The matrix (M) protein of vesicular stomatitis virus inhibits both nuclear import and export. Here, we demonstrate that this inhibitory property is conserved between the M proteins from two other vesiculoviruses, chandipura virus and spring viremia carp virus. All three M proteins completely block nuclear transport of spliced mRNA, small nuclear RNAs, and small nuclear ribonucleoproteins and slow the nuclear transport of many other cargoes. In all cases where transport was merely slowed by the M proteins, the chandipura virus M protein had the strongest inhibitory activity. When expressed in transfected HeLa cells, active M proteins displayed prominent association with the nuclear rim. Moreover, mutation of a conserved methionine abolished both the inhibitory activity and efficient targeting of the M proteins to the nuclear rim. We propose that all of the vesiculoviral M proteins associate with the same nuclear target, which is likely to be a component of the nuclear pore complex.  (+info)

(6/449) Pathogenesis of experimental vesicular stomatitis virus (New Jersey serotype) infection in the deer mouse (Peromyscus maniculatus).

The pathogenesis of vesicular stomatitis virus (VSV) infection has not been investigated previously in native New World rodents that may have a role in the epidemiology of the disease. In the present study, 45 juvenile and 80 adult deer mice (Peromyscus maniculatus) were inoculated intranasally with VSV New Jersey serotype (VSV-NJ) and examined sequentially over a 7-day period. Virus was detected by means of immunohistochemistry and in situ hybridization in all tissues containing histologic lesions. Viral antigen and mRNA were observed initially in olfactory epithelium neurons, followed by olfactory bulbs and more caudal olfactory pathways in the brain. Virus also was detected throughout the ventricular system in the brain and central canal of the spinal cord. These results support both viral retrograde transneuronal transport and viral spread within the ventricular system. Other tissues containing viral antigen included airway epithelium and macrophages in the lungs, cardiac myocytes, and macrophages in cervical lymph nodes. In a second experiment, 15 adult, 20 juvenile, and 16 nestling deer mice were inoculated intradermally with VSV-NJ. Adults were refractory to infection by this route; however, nestlings and juveniles developed disseminated central nervous system infections. Viral antigen also was detected in cardiac myocytes and lymph node macrophages in these animals. Viremia was detected by virus isolation in 35/72 (49%) intranasally inoculated juvenile and adult mice and in 17/36 (47%) intradermally inoculated nestlings and juveniles from day 1 to day 3 postinoculation. The documentation of viremia in these animals suggests that they may have a role in the epidemiology of vector-borne vesicular stomatitis.  (+info)

(7/449) Comparison of the serum neutralization test and a competitive enzyme-linked immunosorbent assay for the detection of antibodies to vesicular stomatitis virus New Jersey and vesicular stomatitis virus Indiana.

A competitive enzyme-linked immunosorbent assay (C-ELISA) for the detection of antibodies against vesicular stomatitis virus New Jersey (VSV-NJ) and vesicular stomatitis virus Indiana (VSV-IN) was compared with the serum neutralization test (SNT) using 1,106 serum samples obtained from dairy cattle on sentinel study farms in the Poas region of Costa Rica. Kappa coefficients between the C-ELISA and the SNT were 0.8871 (95% confidence interval [CI]: 0.8587-0.9155) and 0.6912 (95% CI: 0.6246-0.7577) for the VSV-NJ and VSV-IN tests, respectively. These results indicate good to excellent agreement between the 2 tests under these conditions.  (+info)

(8/449) Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus.

In a model system to study factors involved in the establishment of a persistent viral infection that may lead to neurodegenerative diseases, Indiana and New Jersey variants of vesicular stomatitis virus (VSV) with different capacities to infect and persist in human neural cells were studied. Indiana matrix (M) protein mutants and the wild-type New Jersey strain persisted in the human neural cell line H4 for at least 120 days. The Indiana wild-type virus (HR) and a non-M mutant (TP6), both unable to persist, induced apoptosis more strongly than all the other variants tested, as indicated by higher levels of DNA fragmentation and caspase-3-like activity. Transfection of H4 cells with mRNA coding for the VSV M protein confirmed the importance of this protein in the induction of apoptosis. Furthermore, the pan-caspase inhibitor ZVAD-fmk maintained cell survival to about 80%, whereas inhibition of caspase-8, caspase-9, or both only partially protected the cells against death, consistent with the fact that anti-apoptotic molecules from the Bcl-2 family also protect cells from death only partially. These results suggest that VSV activates many pathways of cell death and that an inefficient induction of caspase-3-related apoptosis participates in the establishment of a persistent infection of human neural cells by less virulent VSV variants.  (+info)



vesicular

  • The family of vesiculovirus matrix proteins consists of several matrix proteins of the vesicular stomatitis virus, also known as VSIV or VSV. (wikipedia.org)
  • Vesiculovirus , which contains vesicular stomatitis virus, Lyssavirus , which contains rabies, Ephemerovirus , which causes bovine ephemeral fever virus and Norvirhabdovirus , which are the fish rhabdoviruses that cause viral hemorrhagic septicemia, infectious hemopoietic necrosis, spring viremia of carp. (thefreedictionary.com)
  • Vesicular stomatitis Indiana virus (VSIV) is the prototypic member of the genus Vesiculovirus of the family Rhabdoviridae. (omicsgroup.org)
  • It has two genera- Vesiculovirus , which causes vesicular stomatitis in horses, cattle and pigs,rarely infects humans & Lyssavirus , which comprises rabies virus. (blogspot.com)

matrix proteins

  • This family consists of several Vesiculovirus matrix proteins. (ebi.ac.uk)

genus

  • Vesiculovirus is a genus of negative-sense ssRNA viruses in the family Rhabdoviridae, within the order Mononegavirales. (wikipedia.org)