Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Skin DiseasesSystemic Vasculitis: A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Vasculitis, Central Nervous System: Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)

*  Leucocytoclastic vasculitis due to Oxicam

The diagnostic of Leukocytoclastic vasculitis was made. A treatment with colchicine was introduced, with good improvement after ... and the clinician should be aware of uncommon but not rare possibility that a cutaneous eruption could evolve into a ... Vasculitis is an inflammatory disease of blood vessels characterized by the alteration or destruction of the vessel wall. A 55 ... Key words: Leukocytoclastic vasculitis, ulcerated nodular lesion, purpuritic lesion, oxicam © Hafsae Bounniyt et al. The Pan ...
panafrican-med-journal.com/content/article/27/89/full/

*  Andre N. Sofair, MD, MPH > Internal Medicine | Yale School of...

Chalkias S, Samson SN, Tiniakou E, Sofair AN: Poststreptococcal cutaneous leukocytoclastic vasculitis: a case report. Conn Med ...
medicine.yale.edu/intmed/people/andre_sofair-2.profile

*  Dermatologic Manifestations of Paraneoplastic Syndromes: Overview, Papulosquamous Disorders, Erythematous Lesions

... and their clinical courses should not significantly differ Remote cutaneous manifestations should be specific to the tumor ... cutaneous leukocytoclastic vasculitis, [38] and capillary damage seen in muscle biopsy samples. Pediatric DM is only rarely ... Lulla P, Bandeali S, Baker K. Fatal paraneoplastic systemic leukocytoclastic vasculitis as a presenting feature of chronic ... Florid cutaneous papillomatosis. First described by Pollitzer in 1891, florid cutaneous papillomatosis (FCP) is characterized ...
https://emedicine.medscape.com/article/1095113-overview

*  Vasculitis 2013

... 模組 Vasculitis 魏正宗 中山醫學大學附設醫院過敏免疫風濕科主任 Tel: 04 ... IgA vasculitis, Henoch-Schönlein purpura Cryoglobulinemic vasculitis Cutaneous leukocytoclastic angiitis ... Microscopic polyangiitis (Leukocytoclastic vasculitis) * 31. IgA Vasculitis (Henoch-Schönlein purpura)    A specific ... Vasculitis 2013 * 1. 醫學系「免疫與感染學 V 」模組 Vasculitis 魏正宗 中
https://slideshare.net/wei3228/vasculitis-2013

*  Chapter 24. Inflammatory Rheumatic Diseases | Pathophysiology of Disease, 6e | AccessMedicine | McGraw-Hill Medical

Cutaneous Small-Vessel (Leukocytoclastic) Vasculitis. ++. A common clinical presentation of immune complex-induced vasculitis ... vasculitis. When it manifests itself in the skin, it is also called cutaneous small vessel or leukocytoclastic vasculitis. ... Cutaneous immune complex vasculitis seldom causes severe pain or tissue breakdown and only rarely leads to long-term injury ( ... vasculitis occur?. *10. What are the three most prominent organ systems affected by immune complex vasculitis? Describe the ...
accessmedicine.mhmedical.com/content.aspx?bookid=339§ionid=42811324

*  A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis | Allergy, Asthma &...

Histopathological examinations revealed that the cutaneous lesions result from leukocytoclastic vasculitis. Immunofluorescence ... which showed leukocytoclastic vasculitis. Immunohistochemical study with anti-IgA antibody was not performed. A treatment with ... studies have revealed immunoglobulin (Ig) and complement component deposits in the cutaneous blood vessels and kidney, but ...
https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-7-5

*  Buy Lovenox Online - Buy blood thinner Medicine @ TheDrugCompany.com

Very rare cases of hypersensitivity cutaneous vasculitis have been reported. These cases may include leukocytoclastic ... vasculitis. LOVENOX should be discontinued in patients showing local or systemic allergic responses. ...
thedrugcompany.com/blood_thinner/lovenox/

*  Differential Diagnosis: infantile digital fibromatosis

Cutaneous Small-vessel Vasculitis (67 %) ( Cutaneous Leukocytoclastic Angiitis, Cutaneous Leukocytoclastic Vasculitis, ... Neurothekeoma (62 %) ( Bizarre Cutaneous Neurofibroma, Cutaneous Lobular Neuromyxoma, Myxoma Of The Nerve Sheath, Myxomatous ... Cutaneous Necrotizing Venulitis, Hypersensitivity Angiitis,). Dermatofibroma (62 %) ( Benign Fibrous Histiocytoma, Dermal ...
gulfdoctor.net/dermbase/differential.php?disease=infantile digital fibromatosis

*  Differential Diagnosis: Sicca Syndrome

Cutaneous Small-vessel Vasculitis (54 %) ( Cutaneous Leukocytoclastic Angiitis, Cutaneous Leukocytoclastic Vasculitis, ... Urticarial Vasculitis (35 %) ( Chronic Urticaria AsA Manifestation Of Venulitis, Hypocomplementemic Urticarial Vasculitis ... Acrochordon (35 %) ( Cutaneous Papilloma, Cutaneous Tag, Fibroepithelial Polyp, Fibroma Molluscum, Fibroma Pendulum, Papilloma ... Diffuse LargeB-cell Lymphoma (30 %) ( Primary Cutaneous LargeB-cell Lymphoma,). Hypohidrosis (30 %) ( Anhidrosis,). Anhidrosis ...
gulfdoctor.net/dermbase/differential.php?disease=Sicca Syndrome

*  Differential Diagnosis: Mikulicz Disease

Cutaneous Small-vessel Vasculitis (54 %) ( Cutaneous Leukocytoclastic Angiitis, Cutaneous Leukocytoclastic Vasculitis, ... Eosinophilic Vasculitis (30 %). Primary Cutaneous LargeB-cell Lymphoma (30 %) ( Diffuse LargeB-cell Lymphoma,). Thrombotic ... Urticarial Vasculitis (35 %) ( Chronic Urticaria AsA Manifestation Of Venulitis, Hypocomplementemic Urticarial Vasculitis ... Acrochordon (35 %) ( Cutaneous Papilloma, Cutaneous Tag, Fibroepithelial Polyp, Fibroma Molluscum, Fibroma Pendulum, Papilloma ...
gulfdoctor.net/dermbase/differential.php?disease=Mikulicz Disease

*  Differential Diagnosis: Cryoglobulinemic Purpura

Cutaneous Small-vessel Vasculitis (75 %) ( Cutaneous Leukocytoclastic Angiitis, Cutaneous Leukocytoclastic Vasculitis, ... Cryoglobulinemic Vasculitis (75 %). Relapsing Polychondritis (75 %) ( Atrophic Polychondritis, Systemic Chondromalacia,). ... Hypersensitivity Vasculitis (75 %). Acrodermatitis Chronica Atrophicans (75 %) ( Herxheimer Disease, Primary Diffuse Atrophy,) ... Livedoid Vasculopathy (100 %) ( Atrophie Blanche, Livedo Reticularis With Summer Ulceration, Livedoid Vasculitis, Purple ...
gulfdoctor.net/dermbase/differential.php?disease=Cryoglobulinemic Purpura

*  Differential Diagnosis: Ecthyma Contagiosum

Cutaneous Small-vessel Vasculitis (54 %) ( Cutaneous Leukocytoclastic Angiitis, Cutaneous Leukocytoclastic Vasculitis, ... Cutaneous Necrotizing Venulitis, Hypersensitivity Angiitis,). Heloderma (50 %) ( Knuckle Pads,). Glomus Tumor (50 %) ( ...
gulfdoctor.net/dermbase/differential.php?disease=Ecthyma Contagiosum

*  Abstracts from the 3rd World Congress of Dermoscopy, May 17 to 19, 2012, Brisbane Australia - Derm101

... is a subset of vasculitis characterized clinically by urticarial skin lesions and histologically by leukocytoclastic vasculitis ... Dermoscopic and histopathological findings of polymorphous vessels in amelanotic cutaneous metastasis of pigmented cutaneous ... but histological diagnosis was available to show the early phase of leukocytoclastic vasculitis characterized by prominent ... Clinical, histological and dermoscopic changes over time in urticarial vasculitis. M. S. Jang, J. B. Park, D. Y. Kang, J. S. ...
derm101.com/dpc/april-2012-volume-2-no-2/abstracts-from-the-3rd-world-congress-of-dermoscopy-may-17-to-19-2012-brisbane-australia/6270/

*  Surgical Follow-up and Outcomes sub-cluster 39

... are the most common entities included within the category of cutaneous vasculitis (CV). Palpable purpura and histological ... changes characterised by the presence of leukocytoclastic vasculitis are common in both conditions. Therefore, considerable ... Revisiting clinical differences between hypersensitivity vasculitis and Henoch-Schönlein purpura in adults from ... ... Hypersensitivity vasculitis (HV) and Henoch-Schönlein purpura (HSP) ...
biomedsearch.com/cluster/27/Surgical-Follow-up-and-Outcomes/sub-39-p3.html

*  Diagnosis and management of ANCA associated vasculitis | The BMJ

... histological studies often revealed a pattern consistent with leukocytoclastic vasculitis with or without thrombotic ... we frequently see cocaine users with neutropenia and cutaneous vasculopathy.(3) In many of these cases, ANCA were specifically ... Re: Diagnosis and management of ANCA associated vasculitis. Among the small vessel vasculitis which affects vessels like ... Re: Diagnosis and management of ANCA associated vasculitis. Berden and Co-authors have composed a useful presentation of ANCA- ...
bmj.com/content/344/bmj.e26/rapid-responses

*  Fluoxetine Solution - FDA prescribing information, side effects and uses

In neither patient was there an unequivocal diagnosis, but one was considered to have a leukocytoclastic vasculitis, and the ... In premarketing clinical trials, 2 patients are known to have developed a serious cutaneous systemic illness. ... Since the introduction of fluoxetine, systemic reactions, possibly related to vasculitis and including lupus-like syndrome, ... other, a severe desquamating syndrome that was considered variously to be a vasculitis or erythema multiforme. Other patients ...
https://drugs.com/pro/fluoxetine-solution.html

*  Differential Diagnosis: epithelioidhemangioendothelioma

Cutaneous Small-vessel Vasculitis (62 %) ( Cutaneous Leukocytoclastic Angiitis, Cutaneous Leukocytoclastic Vasculitis, ... Erythema Induratum (69 %) ( Bazin Disease, Nodular Vasculitis,). Multiple Endocrine Neoplasia Type3 (69 %) ( Mucosal Neuromata ... Cutaneous Lymphoid Hyperplasia (69 %) ( Borrelial Lymphocytoma, Lymphadenosis Benigna Cutis, Lymphocytoma Cutis, Pseudolymphoma ... Cutaneous Necrotizing Venulitis, Hypersensitivity Angiitis,). Crest Syndrome (62 %) ( Calcinosis raynaud Phenomenon esophageal ...
gulfdoctor.net/dermbase/differential.php?disease=epithelioidhemangioendothelioma

*  Most recent papers with the keyword Ocular lymphoma | Read by QxMD

... leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type ... cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens ... syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic ... linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris... ...
https://readbyqxmd.com/keyword/84058

*  Most recent papers with the keyword linear iga bullous dermatosis | Read by QxMD

... leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type ... Polycyclic, grouped bullae on cutaneous skin are the most characteristic clinical feature of LABD. Lesions are often ... Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous ... Neither treatment with mupirocin nor methylprednisolone therapy achieved remission of cutaneous lesions. Skin biopsy showed a ...
https://readbyqxmd.com/keyword/39218

*  Buruli Ulcer Workup: Approach Considerations, Laboratory Studies, Imaging Studies

In active lesions, the inflammatory infiltrate is usually absent to mild, although a leukocytoclastic vasculitis or thrombosis ... Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer ... with destruction of cutaneous nerves, blood vessels, and adnexal structures. The necrosis may extend well beyond the edges of ...
https://emedicine.medscape.com/article/1104891-workup

*  Spider Bites - Injuries; Poisoning - Merck Manuals Professional Edition

Leukocytoclastic vasculitis. Sporotrichosis. Toxic epidermal necrolysis. Infections. Chronic herpes simplex. Cutaneous anthrax ...
merckmanuals.com/professional/injuries-poisoning/bites-and-stings/spider-bites?Ref=t&ItemId=v8552059&RefId=injuries_poisoning/bites_and_stings/spider_bites&Speed=256&Plugin=WMP&Error=

*  Clorambucile - Wikipedia

Kapoor, Paraneoplastic leukocytoclastic vasculitis in chronic lymphoid leukemia., in J Cancer Res Ther, vol. 2, nº 4, pp. 206-8 ... Doherty, T. Rosen, Evidence-based therapy for cutaneous sarcoidosis., in Drugs, vol. 68, nº 10, 2008, pp. 1361-83, PMID ... P. Berlit, [Vasculitis], in Ther Umsch, vol. 53, nº 7, luglio 1996, pp. 559-67, PMID 8711631. ^ P. Ferrari, FJ. Frey, [ ... Fauci, Pulmonary vasculitis., in Am Rev Respir Dis, vol. 134, nº 1, luglio 1986, pp. 149-66, PMID 2873770. Paolo Romanelli, ...
https://it.wikipedia.org/wiki/Clorambucile

*  Mitoxantrone - Phadia - Setting the Standard - Phadia.com - test

Cutaneous: rashes (vesicular and erythematous), facial edema.. Diagnostic methods. Skin biopsy: leukocytoclastic vasculitis in ...
inter-2t.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergens/Online-Books/Drug-Allergy/IV-Chemotherapy-drugs-and-immunosuppressors/Mitoxantrone/

*  05/01/2011 - 06/01/2011 | Free Online Medical Powerpoint Presentations Collection eMedical PPT

Drug-related (cutaneous leukocytoclastic angiitis). Henoch-Schonlein Purpura (HSP) - IgA deposits. Goodpasture's disease. ... Large-vessel vasculitides Medium-vessel vasculitides Small-vessel vasculitides (many). ANCA-associated. Non-ANCA-associated ( ... Drug-induced ANCA vasculitis. Idiopathic. Non-ANCA-associated Infectious (Hep B, Hep C, HIV, Parvo, CMV, EBV). CVD-related (RA ... Vasculitis: Inflammation of blood vessels causing vessel and tissue damage. Classification is according to the Chapel Hill ...
emedicalppt.blogspot.com/2011/05/

*  Cutaneous LM | definition of Cutaneous LM by Medical dictionary

Cutaneous LM explanation free. What is Cutaneous LM? Meaning of Cutaneous LM medical term. What does Cutaneous LM mean? ... Looking for online definition of Cutaneous LM in the Medical Dictionary? ... cutaneous leishmaniasis, diffuse. *cutaneous leprosy. *cutaneous leukocytoclastic angiitis. *Cutaneous LM. *cutaneous loop ... cutaneous T-cell lymphoma. *cutaneous transpiration. *cutaneous tuberculosis. *cutaneous ureterostomy. *cutaneous vasculitis ...
https://medical-dictionary.thefreedictionary.com/Cutaneous LM

(1/116) Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.

We describe a patient who presented with Wegener's granulomatosis associated with antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) with a cytoplasmic immunofluorescence pattern (cANCA), whose ANCA type changed to antimyeloperoxidase antibodies with a perinuclear immunofluorescence pattern (pANCA) when treated with propylthiouracil, and changed back to anti-PR3 antibodies with cANCA after the medication was discontinued. The patient developed flares of vasculitis symptoms associated with rises in either type of ANCA. Tests for antimyeloperoxidase ANCA were repeatedly negative before the drug was started, strongly implicating the drug as the cause of the episode. This case demonstrates that patients with idiopathic ANCA-positive vasculitis may quickly develop a superimposed drug-associated ANCA-positive vasculitis. Iatrogenic vasculitis should be suspected when a patient with idiopathic vasculitis with one type of ANCA develops the other type of ANCA.  (+info)

(2/116) Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients.

OBJECTIVE: To retrospectively analyze the clinical symptoms, laboratory findings, and outcomes in patients with microscopic polyangiitis (MPA) who were enrolled in various clinical trials conducted by the French Vasculitis Study Group. METHODS: A cohort of 85 patients meeting the Chapel Hill criteria for MPA participated in the study. Seventy-one of them were included in prospective therapeutic trials. Eighty-one diagnoses were biopsy proven. In the other patients, diagnosis was based on clinical findings. RESULTS: Forty-seven men and 38 women, with a mean +/- SD age of 56.8 +/- 14.6 years, met the criteria for MPA. Their main clinical symptoms were renal manifestations (78.8%), weight loss (72.9%), skin involvement (62.4%), fever (55.3%), mononeuritis multiplex (57.6%), arthralgias (50.6%), myalgias (48.2%), hypertension (34.1%), lung involvement (24.7%; alveolar hemorrhage 11.8%), and cardiac failure (17.6%). The mean +/- SD serum creatinine level before treatment was 2.59 +/- 2.96 mg/dl; 47 patients had renal insufficiency (serum creatinine > 1.36 mg/dl). Eight patients underwent dialysis at the time of diagnosis, and long-term dialysis was necessary for 10 patients. Antineutrophil cytoplasmic antibodies (ANCA) were present in 38 of 51 patients (74.5%), of whom 33 had a perinuclear staining pattern (pANCA) and 5 had a cytoplasmic pattern. Antibodies to proteinase 3 were present in 4 patients and antibodies to myeloperoxidase were detected in 31, as determined by enzyme-linked immunosorbent assay. Of the 30 patients who underwent renal and celiac angiography, 4 had microaneurysms. Of the 29 patients (34.1%) who had relapses, 8 died during or after the relapse. During followup, 28 of the 85 patients (32.9%) died. The mean +/- SD duration of followup of the group was 69.9 +/- 60.6 months. Deaths were less frequent when patients had been treated with steroids and immunosuppressive drugs (13 patients [24.1%]) than with steroids alone (15 patients [48.4%]) (P < 0.01). The 5-year survival rate was 74%. CONCLUSION: This study demonstrated that MPA is a multisystemic disease in which renal symptoms are frequent, but the disease is also associated with general symptoms, arthritis, mononeuritis multiplex, and other manifestations that are also seen in various vasculitides. The rarity of abnormal angiogram findings and the high frequency of pANCA are characteristic of MPA. In most cases, the outcome is comparable with those of other systemic vasculitides, but relapses are frequent.  (+info)

(3/116) Immune complexes from vasculitis patients bind to endothelial Fc receptors independent of the allelic polymorphism of FcgammaRIIa.

Cutaneous leukocytoclastic vasculitis is characterized by the deposition of circulating immune complexes, neutrophil extravasation, and vessel destruction, but mechanisms of circulating immune complexes capture within postcapillary venules are unknown. We demonstrate that circulating immune complexes from sera of vasculitis patients bind to cultured endothelium in an Fc gamma receptor IIa-dependent fashion. In lesional skin, endothelial cells bind immunoglobulin G2 > immunoglobulin G3 and immunoglobulin G4, but not immunoglobulin G1, even before obvious neutrophil transmigration and vessel damage. As the human Fc gamma receptor IIa proteins exist in two allotypes (one with a histidine at position 131, which binds immunoglobulin G1, 2, 3 and the other with an arginine at position 131, which binds immunoglobulin G1, and 3, but is unable to bind immunoglobulin G2), we expected an altered prevalence of histidine 131 forms in vasculitis patients. Sequence analysis, however, revealed an equal distribution of allotypes in patients and controls. In conclusion, circulating immune complex binding to endothelial Fc gamma receptor IIa is among the initial steps in the development of vasculitis. Although immunoglobulin G2 is the predominant subtype precipitated at endothelial surfaces, it is not required for fixing circulating immune complexes to endothelium, because patients homozygote for Fc gamma receptor IIa-arginine 131 equally develop leukocytoclastic vasculitis as those bearing the Fc gamma receptor IIa-histidine 131 allele. As immunoglobulin G1 is virtually absent in leukocytoclastic vasculitis lesions and immunoglobulin G4 does not bind to both Fc gamma receptor IIa alleles, these complexes, in addition to immunoglobulin G2, should contain immunoglobulin G3 in order to fix to vascular Fc gamma receptor IIa, at least in persons homozygous for Fc gamma receptor IIa-arginine 131. KEYWORDS: CD32/immunoglobulin G subtypes/leukocytoclastic vasculitis/microvessels.  (+info)

(4/116) Early vasculitis in the mercuric chloride induced Brown Norway rat model is neutrophil independent.

In the Brown Norway rat, mercuric chloride (HgCl2) induces an autoimmune syndrome characterized by necrotizing vasculitis, predominantly affecting the caecum, and a polyclonal B-cell response. The time course of vasculitis is biphasic, with an alphabeta T-cell independent phase occurring within 24 h, and a T-cell and neutrophil dependent phase, maximal at two weeks. The pathogenesis of the early phase of vasculitis is unclear, and this study aims to examine the role of neutrophils. Rat neutrophils were depleted using cyclophosphamide. RP3, an antirat neutrophil monoclonal antibody, inhibited neutrophil leucocytosis but did not deplete neutrophils. Vasculitis was induced by subcutaneous HgCl2 injection. Serial measurements of peripheral blood leucocyte count were made. Rats were killed after 24 or 72 h. The macroscopic appearance of the caecum was scored by an experienced observer, and samples taken for histological examination. Caecums were excised and myeloperoxidase, a marker enzyme for neutrophil infiltration, assayed. Cyclophosphamide induced marked neutropaenia whereas RP3 inhibited the neutrophilia observed after HgCl2 injection. Vasculitis was present in both treated and control animals, with no significant differences in macroscopic or microscopic scores between the groups. Tissue myeloperoxidase activity was low in all animals and did not differ significantly between groups. The data do not support a role for neutrophils in the initial pathogenesis of vasculitis in this model.  (+info)

(5/116) A prospective study of vasculitis patients collected in a five year period: evaluation of the Chapel Hill nomenclature.

OBJECTIVE: To test the usefulness of the Chapel Hill nomenclature, supplemented with surrogate parameters, as diagnostic criteria for primary vasculitides. METHODS: To prospectively evaluate vasculitis patients according to a standardised clinical and para-clinical programme. In accordance with the Chapel Hill publication surrogate parameters were used: proteinuria, haematuria and red blood cell casts (glomerulonephritis), angiographic or ultrasonic demonstration of aneurysms or stenoses (arteritis), radiological lung infiltrates or cavitations of more than one month's duration (granuloma in the lungs), bloody nasal discharge or crusts, chronic sinusitis, otitis and/or mastoiditis, bone and/or cartilage destruction, and acute hearing loss (granuloma in upper airways). RESULTS: The following entities were diagnosed: giant cell arteritis (n=14), Takayasu arteritis (n=1), polyarteritis nodosa (n=2), Wegener's granulomatosis (n=27), Churg-Strauss syndrome (n=2), microscopic polyangiitis (n=12), Henoch-Schonlein purpura (n=2), cutaneous leucocytoclastic angiitis (n=37), and secondary vasculitis (n=21). Giant cell arteritis and cutaneous leucocytoclastic angiitis were in all cases diagnosed by biopsy. Using the Chapel Hill nomenclature supplemented with surrogate parameters, only 8 of 27 patients were diagnosed with Wegener's granulomatosis, and 3 of 12 cases with microscopic polyangiitis. The number of patients in the remaining diagnostic entities were considered to few to evaluate. CONCLUSIONS: The Chapel Hill nomenclature, supplemented with surrogate parameters, failed to act as diagnostic criteria in Wegener's granulomatosis and microscopic polyangiitis. The following diagnostic criteria are proposed for Wegener's granulomatosis: (1) Biopsy or surrogate parameter for granulomatous inflammation in the respiratory system and (2) Biopsy verified necrotising vasculitis in small to medium sized vessels or biopsy/surrogate parameter for glomerulonephritis or positive PR3-ANCA test and (3) Lack of eosinophilia in blood and biopsy samples. The following diagnostic criteria are proposed for microscopic polyangiitis: (1) Biopsy verified necrotising vasculitis in small vessels and/or glomerulonephritis with few or no immune deposits and (2) Involvement of more than one organ system as indicated by biopsy verified vasculitis in small to medium sized vessels or surrogate parameter for glomerulonephritis and (3) Lack of biopsy and surrogate parameter for granulomatous inflammation in the respiratory system. Using these criteria all Wegener's patients and 9 of 12 patients with microscopic polyangiitis could be diagnosed.  (+info)

(6/116) Unusual manifestations of type II cryoglobulinaemia associated with Waldenstrom's macroglobulinaemia.

Cryoglobulinaemia in association with Waldenstrom's macroglobulinaemia is relatively common, ranging from 8% to 18% of cases; however, < 5% have symptoms or complications. We describe a patient with a history of cutaneous, peritoneal, and fallopian tube vasculitis related to type II cryoglobulinaemia associated with Waldenstrom's macroglobulinaemia. Cytotoxic treatment was initiated (cyclophosphamide, vincristine, and prednisone) and had a good initial response. However, after the third course of chemotherapy, the patient presented with septic shock and died. Even though cryoglobulinaemia is a model of systemic vasculitis, peritoneal and fallopian tube vasculitis associated with type II cryoglobulinemia has not been described previously.  (+info)

(7/116) Leukocytoclastic vasculitis as a complication of infected total hip prosthesis.

We present a case of leukocytoclastic vasculitis, associated with an exacerbation of chronic osteomyelitis in a pseudoarthrosis of the hip. Skin lesions of the lower limb were the most prominent features.  (+info)

(8/116) Follicular dendritic cell tumor of the liver: a clinicopathologic and Epstein-Barr virus study of two cases.

Two cases of hepatic follicular dendritic cell (FDC) tumor are described. Both patients were female, aged 57 and 51 years. They presented with epigastralgia or abdominal fullness and weight loss. The first patient refused surgical resection. She developed progressive polyclonal gammopathy and then bilateral purpura over the legs. Skin biopsy revealed leukocytoclastic vasculitis with granular vascular deposits of IgA and C3. The second patient had marked peripheral blood and tissue eosinophilia. The histological diagnosis was confirmed by positive staining for CD21 and CD23. The stromal lymphocytes were predominantly composed of CD3(+)and CD8(+) cells. In situ hybridization for EBER showed a positive nuclear signal in tumor cells but not in inflammatory cells. Polymerase chain reaction amplification for Exon 3 of the latent membrane protein-1 (LMP-1) gene showed a characteristic 30-bp deletion between nucleotides 168282 and 168253, corresponding to the B95-8 sequence. The unique clinicopathological features of our cases have not been reported for FDC tumors before. The clinical significance of the 30-bp deletion in Exon 3 of the LMP-1 gene in FDC tumor of the liver warrants further investigation.  (+info)



vessels


  • Vasculitis is an inflammatory disease of blood vessels characterized by the alteration or destruction of the vessel wall. (panafrican-med-journal.com)
  • As is known, ANCA associated vasculitis is characterized by necrotizing granulomatous lesions that affect different vessels and organs, most commonly the kidney and lungs. (bmj.com)