Tuberculin Test: One of several skin tests to determine past or present tuberculosis infection. A purified protein derivative of the tubercle bacilli, called tuberculin, is introduced into the skin by scratch, puncture, or interdermal injection.Tuberculin: A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.Tuberculosis, Bovine: An infection of cattle caused by MYCOBACTERIUM BOVIS. It is transmissible to man and other animals.HistoryBCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.Tuberculosis, Pulmonary: MYCOBACTERIUM infections of the lung.Mycobacterium bovis: The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Latent Tuberculosis: The dormant form of TUBERCULOSIS where the person shows no obvious symptoms and no sign of the causative agent (Mycobacterium tuberculosis) in the SPUTUM despite being positive for tuberculosis infection skin test.Hypersensitivity, Delayed: An increased reactivity to specific antigens mediated not by antibodies but by cells.Interferon-gamma Release Tests: The assay of INTERFERON-GAMMA released from lymphocytes after their exposure to a specific test antigen, to check for IMMUNOLOGIC MEMORY resulting from a previous exposure to the antigen. The amount of interferon-gamma released is usually assayed by an ENZYME-LINKED IMMUNOSORBENT ASSAY.Mycobacterium tuberculosis: A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.

*  Mantoux test financial definition of Mantoux test
What is Mantoux test? Meaning of Mantoux test as a finance term. What does Mantoux test mean in finance? ... Definition of Mantoux test in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Mantoux tuberculin skin test. *Mantoux tuberculin skin test. *Mantoux tuberculin skin test ... test. (redirected from Mantoux test). Also found in: Dictionary, Thesaurus, Medical, Legal, Encyclopedia, Wikipedia. Test. The ...
  https://financial-dictionary.thefreedictionary.com/Mantoux+test
*  Sure, put tuberculin in everyone's eyes. | Amboceptor
... you've probably been given the tuberculin skin test. You get a little injection under the top layer of your skin, forming a ... The tuberculin skin test is also known as the Mantoux test, and has been for over a century, since Mantoux's practical ... These tests involved administration of tuberculin to different sites in the body: conjuctiva (Calmette); deep muscle (Moro); ... The ease of implementing the test (application of a few drops of tuberculin to the surface of the eye) and the relatively ...
  https://amboceptor.wordpress.com/2014/05/30/should-i-put-tuberculin-in-your-eye/comment-page-1/
*  Tuberculin Skin Test (Mauntoux test):Principle, Procedure, Results and Limitations - microbeonline
Interpretation of Tuberculin skin test (montoux test) results. Interpretation of tuberculin skin test always remains difficult ... Mantoux Tuberculin Skin Test: Training Materials Kit (2003).. *CDC. Targeted tuberculin testing and treatment of latent ... Tuberculin Skin Test (Mauntoux test):Principle, Procedure, Results and Limitations 5/5 (1) August 22, 2015. by Nisha Rijal in ... Administration of the test. Tuberculin skin test (TST) is an intradermal injection. It is performed by injecting 0.1 ml of ...
  http://microbeonline.com/tuberculin-skin-test-mauntoux-testprinciple-procedure-results-limitations/
*  The Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Tuberculosis Infection - Full...
The agreement between QuantiFERON-TB Gold(QFT-G) and tuberculin skin test(TST) as a screening test for latent tuberculosis ... The Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Tuberculosis Infection. The ... to compare the positivity of tuberculin skin test(TST) and QuantiFERON-TB Gold (QFT-G), and determine the level of agreement ... Evaluation of the Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Mycobacterium ...
  https://clinicaltrials.gov/ct2/show/NCT01685905
*  Es suficiente la prueba tuberculínica para el diagnóstico de la infección tuberculosa?
DE KANTOR, Isabel N. y RITACCO, Viviana. Is the tuberculin skin test still suitable to diagnose tuberculosis infection?. ... Palabras clave : Tuberculin skin test; PPD; IFN-? release assays; Tuberculosis infection; Mycobacterium tuberculosis. ... Tuberculosis (TB) infection is currently being diagnosed by the tuberculin skin test (TST) with PPD. Some Mycobacterium ...
  http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-76802009000400014&lng=es&nrm=iso&tlng=en
*  tb patch test jersey
Tuberculin skin test: The TB skin test (also called the Mantoux tuberculin skin test) The State University of New Jersey; TB ... and what the results of an allergy blood test might. Apr 09, 2014 · Tuberculin skin test: The TB skin test Testing Diagnosis; ... Tuberculin Skin Testing What is it? The Mantoux tuberculin skin test (TST) is the standard method of determining whether a ... The tuberculosis skin test is also known as the tuberculin test or PPD (purified . Seagate® Expansion® external hard drive ...
  http://pdvfuxy1973.cba.pl/tb-patch-test-jersey.html
*  Pilot Open Label Clinical Trial With Abatacept in Ankylosing Spondylitis - Full Text View - ClinicalTrials.gov
... all potential subjects will have a Tuberculin skin test at screening. *Patients with other chronic inflammatory articular ... Women lactating, pregnant, nursing or of childbearing potential with a positive pregnancy test (urine test) ... Any other laboratory test result that, in the opinion of the investigator, might place the subject at unacceptable risk for ... Try the new test version at https://clinicaltrials.gov/beta/. Show less ...
  https://clinicaltrials.gov/ct2/show/NCT00558506?recr=Open&cond=%22Bone+Diseases%2C+Infectious%22&rank=9
*  Positive TB test: Am I sick?
... the tuberculin skin reactivity test (also called the Mantoux Test) and the TB blood test. The skin test will help to determine ... Positive TB test: Am I sick? [1]. Dear Alice,. What does a positive result of a TB test mean? Once a person is positive, is ... The TB blood test, on the other hand, measures whether a person's white blood cells will react to TB bacteria. A positive blood ... TB or not TB: that is the question! A person who tests positive for tuberculosis (TB) has likely been exposed (at some point in ...
  http://goaskalice.columbia.edu/print/431216
*  Sabinet | Interpretation of the multiple puncture tuberculin reaction
It is suggested that multiple puncture tuberculin reactions be interpreted in 2 classes : papular, representative of cross- ... Keyword(s) : Heaf test, Multiple puncture tuberculin reaction, Pathology and Technique * Accreditation : Department of Higher ... oa South African Medical Journal - Interpretation of the multiple puncture tuberculin reaction * Navigate this Journal ... It is suggested that multiple puncture tuberculin reactions be interpreted in 2 classes : papular, representative of cross- ...
  http://journals.co.za/content/m_samj/44/45/AJA20785135_33201
*  Page 1617 :: State Publications
... including the tuberculin test, and revocable upon violation of those rules. Every municipality should adopt and enforce an ... including the tuberculin test, and revocable upon violation of those rules. Every municipality should adopt and enforce an ...
  http://digital.ncdcr.gov/cdm/singleitem/collection/p249901coll22/id/139409/rec/14
*  Tuberculin Market Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017-2022 | Medgadget
Tuberculin, also known as purified protein derivative is a combination of proteins that are used in the diagnosis of ... This use is referred to as the tuberculin skin test and is recommended only for those at high risk. Injection is done into the ... Scope of the Global Tuberculin Market Report. This report focuses on the Tuberculin in Global market, especially in North ... Tuberculin Market Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2017-2022. July 19th, 2017 Orbis Research ...
  https://www.medgadget.com/2017/07/tuberculin-market-global-industry-analysis-size-share-growth-trends-and-forecast-2017-2022.html
*  Tuberculin testing. | The BMJ
Tuberculin testing.. Br Med J 1979; 1 doi: https://doi.org/10.1136/bmj.1.6166.823-c (Published 24 March 1979) Cite this as: Br ...
  http://www.bmj.com/content/1/6166/823.4
*  INTRACUTANEOUS TUBERCULIN TESTS | The BMJ
INTRACUTANEOUS TUBERCULIN TESTS. Br Med J 1929; 1 doi: https://doi.org/10.1136/bmj.1.3565.831 (Published 04 May 1929) Cite this ...
  http://www.bmj.com/content/1/3565/831.1
*  Case-finding by Serial Tuberculin-testing of Schoolchildren | The BMJ
Case-finding by Serial Tuberculin-testing of Schoolchildren Br Med J 1963; 2 :717 ... Case-finding by Serial Tuberculin-testing of Schoolchildren. Br Med J 1963; 2 doi: https://doi.org/10.1136/bmj.2.5359.717 ( ...
  http://www.bmj.com/content/2/5359/717
*  Comparison of the tine and Mantoux tuberculin tests. | The BMJ
Comparison of the tine and Mantoux tuberculin tests. Br Med J 1978; 2 :280 ... Comparison of the tine and Mantoux tuberculin tests.. Br Med J 1978; 2 doi: https://doi.org/10.1136/bmj.2.6132.280-a (Published ...
  http://www.bmj.com/content/2/6132/280.2
*  Comparison of tuberculin test and Diaskintest® in the diagnosis of tuberculosis in children | European Respiratory Society
Comparison of tuberculin test and Diaskintest® in the diagnosis of tuberculosis in children. Natalia Korneva, Anna Starshinova ... The aim of this study is to compare specificity and sensitivity of tuberculin skin test (TST) vs Diaskintest ® (DST) in ... Comparison of tuberculin test and Diaskintest® in the diagnosis of tuberculosis in children ... Screening of tuberculosis in children by tuberculin skin test (TST) provides low information, because almost all children have ...
  http://erj.ersjournals.com/content/42/Suppl_57/P4435
*  Interpretation Criteria for Comparative Intradermal Tuberculin Test for Diagnosis of Bovine Tuberculosis in Cattle in Maroua...
... of tuberculin skin test, with detection of Tb lesions plus acid fast bacilli in lesions as the reference test, recorded is ... of tuberculin skin test, with detection of Tb lesions as the reference test, recorded is lower than the median individual ... skin test involving the intradermal injection of bovine tuberculin (BT) and avian tuberculin (AT) at separate sites in the skin ... and prevalence of the disease in the population tested [14]. Excessively high sensitivity of tuberculin skin tests will ...
  https://www.hindawi.com/journals/vmi/2016/4834851/
*  Prevalence of Mycobactrium bovis Infection in Cattle using Intra-dermal Caudal Fold Tuberculin Test in Taraba State, Nigeria - ...
Prevalence of Mycobactrium bovis Infection in Cattle using Intra-dermal Caudal Fold Tuberculin Test in Taraba State, Nigeria ... Key words: Cattle, Intra-dermal Caudal fold, M. bovis, Prevalence, Tuberculin test, Taraba state. ... Netherlands was used in screening the cattle for Mycobacterium bovis infection using intra-dermal caudal fold tuberculin test. ... This recommendation however, may require legislative action in order to make the herdsmen present their cattle for testing. ...
  http://www.scopemed.org/?mno=214865
*  Tuberculin Skin Tests | NMU Ada B. Vielmetti Health Center
Tuberculin skin tests are administered during the following hours:. 9am to 11am on Monday, Tuesday, Wednesday and Friday (NOT ... on Thursday, as we won't be here to read the test). You must return in 2-3 days to have the test read between 9am to 11am or ... Tuberculin Skin Tests. The fee is $25.00. ...
  http://www.nmu.edu/healthcenter/tuberculin-skin-tests
*  Helminths and skewed cytokine profiles increase tuberculin skin test positivity in Warao Amerindians.
We investigated the influence of parasitic infections, malnutrition and plasma cytokine profiles on tuberculin skin ... We investigated the influence of parasitic infections, malnutrition and plasma cytokine profiles on tuberculin skin test (TST) ... testing and stool examinations. Factors associated with TST positivity were studied using generalized estimation equations ...
  http://www.biomedsearch.com/nih/Helminths-skewed-cytokine-profiles-increase/22877977.html
*  Performance of Tuberculin Skin Test Measured against Interferon Gamma Release Assay as Reference Standard in Children
... Michael ... International guidelines differ in the threshold of tuberculin skin test (TST) induration regarded as indicating Mycobacterium ...
  https://www.hindawi.com/journals/trt/2014/413459/abs/
*  Tuberculin Skin Test - October 5, 1960 :: From the Darkroom - Springfield's Historic Newspaper Photographs
David Rudd received his tuberculin skin test during a free testing program offered to all public school first graders. The ... Tuberculin Skin Test. 05 October 1960. Springfield News-Leader Collection. News-Leader, Springfield, Missouri. ...
  http://cdm.sos.mo.gov/cdm/ref/collection/p16795coll19/id/14454/
*  NIOSHTIC-2 Publications Search - 20035993 - Prospective comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube...
Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT-GIT ... We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among ... Prospective comparison of tuberculin skin test and QuantiFERON-TB Gold In-Tube assay for the detection of latent tuberculosis ... We compared the results of the tuberculin skin test with the results of the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay among ...
  https://www.cdc.gov/niosh/nioshtic-2/20035993.html
*  Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis in Patients With HIV? - Full Text View -...
Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis in Patients With HIV?. This study has been completed ... Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis in Patients With HIV?. ... Sensitivity of the PPD testing is, however, dependent on a normal T cell function. ... Patients who have a positive PPD test within 1 year of study enrollment ...
  https://clinicaltrials.gov/show/NCT00763295?order=41
*  COCHIN CARDIAC CLUB: 2013
It may also include a tuberculin skin test, other scans and X-rays, surgical biopsy. ... They do, however, test positive to the Mantoux Skin Test. Treating latent TB is important since it can get activated, ... If your workplace or environment puts you into one of these high-risk groups, a TB test can be a smart way to prevent ... Before the vaccine is given, the person is given a Mantoux skin test to check for latent tuberculosis. Vaccination is not ...
  http://cochincardiacclub.blogspot.com/2013/

Mantoux test: The Mantoux test or Mendel-Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a screening tool for tuberculosis (TB). It is one of the major tuberculin skin tests used around the world, largely replacing multiple-puncture tests such as the Tine test.Mycobacterium bovis: ATCC 19210List of asbestos disease medical articles: Thousands of scientific and medical articles have chronicled human understanding of the hazards of asbestos to human life.Environmental Working Group, List of References regarding asbestos hazards This understanding paralleled the growth of the industrial revolution, particularly in the textile factories and mines of Great Britain.Denise Faustman: Denise L. Faustman, (born 1958) is a U.Tuberculosis managementTuberculosis radiology: Radiology is used in the diagnosis of tuberculosis.Albert CalmetteBeef cattle: Beef cattle are cattle raised for meat production (as distinguished from dairy cattle, used for milk production). The meat of adult cattle is known as beef.QuantiFERON: Interferon-gamma release assays (IGRAs) are diagnostic tools for latent tuberculosis infection (LTBI). They are surrogate markers of Mycobacterium tuberculosis infection and indicate a cellular immune response to M.Mycobacterium tuberculosis complex: Mycobacterium tuberculosis complex refers to a genetically related group of Mycobacterium species that can cause tuberculosis in humans or other organisms.

(1/1105) A train passenger with pulmonary tuberculosis: evidence of limited transmission during travel.

In January 1996, smear- and culture-positive tuberculosis (TB) was diagnosed for a 22-year-old black man after he had traveled on two U.S. passenger trains (29.1 hours) and a bus (5.5 hours) over 2 days. To determine if transmission had occurred, passengers and crew were notified of the potential exposure and instructed to undergo a tuberculin skin test (TST). Of the 240 persons who completed screening, 4 (2%) had a documented TST conversion (increase in induration of > or = 10 mm between successive TSTs), 11 (5%) had a single positive TST (> or = 10 mm), and 225 (94%) had a negative TST (< 10 mm). For two persons who underwent conversion, no other risk factors for a conversion were identified other than exposure to the ill passenger during train and/or bus travel. These findings support limited transmission of Mycobacterium tuberculosis from a potentially highly infectious passenger to other persons during extended train and bus travel.  (+info)

(2/1105) Observations on animal and human health during the outbreak of Mycobacterium bovis in game farm wapiti in Alberta.

This report describes and discusses the history, clinical, pathologic, epidemiologic, and human health aspects of an outbreak of Mycobacterium bovis infection in domestic wapiti in Alberta between 1990 and 1993, shortly after legislative changes allowing game farming. The extent and seriousness of the outbreak of M. bovis in wapiti in Alberta was not fully known at its onset. The clinical findings in the first recognized infected wapiti are presented and the postmortem records for the herd in which the animal resided are summarized. Epidemiologic findings from the subsequent field investigation are reviewed, the results of recognition and investigation of human exposure are updated, and recommendations for reduction of human exposure are presented.  (+info)

(3/1105) Differential avian and human tuberculin skin testing in non-tuberculous mycobacterial infection.

OBJECTIVE: To determine the sensitivity of differential avian and human delayed-type hypersensitivity skin testing in the diagnosis of non-tuberculous mycobacterial lymphadenitis. METHOD: Retrospective review of all patients with culture proved non-tuberculous mycobacterial lymph node infections who also had differential avian and human skin testing performed over a 10 year period from 1986 to 1996. RESULTS: One hundred and twenty four patients had non-tuberculous mycobacteria isolated from lymph nodes over this period, 59 of whom had differential skin testing performed. The sensitivity of a response of >/= 10 mm to the avian precipitin was 58 of 59. No patient had both a negative human and avian Mantoux. The sensitivity of the human Mantoux alone for diagnosing non-tuberculous mycobacterial infection was 81% for a response of >/= 5 mm and 66% for >/= 10 mm. Ten patients had a 0 human response. Fifty five of the 59 patients had an avian response at least 2 mm greater than the human response. CONCLUSION: The avian Mantoux is a very sensitive method of diagnosing non-tuberculous mycobacterial infection in children. The human Mantoux is not sensitive enough to be used alone as a surrogate to diagnose non-tuberculous mycobacterial infection.  (+info)

(4/1105) Prevalence of Mycobacterium tuberculosis infection among injection drug users in Toronto.

BACKGROUND: Injection drug users are at increased risk of Mycobacterium tuberculosis infection and active tuberculosis (TB). The primary objective of this study was to determine the prevalence of M. tuberculosis infection among injection drug users in Toronto, as indicated by a positive tuberculin skin test result. An additional objective was to identify predictors of a positive skin test result in this population. METHODS: A cross-sectional study was carried out involving self-selected injection drug users in the city of Toronto. A total of 171 participants were recruited through a downtown Toronto needle-exchange program from June 1 to Oct. 31, 1996. RESULTS: Of 167 subjects tested, 155 (92.8%) returned for interpretation of their skin test result within the designated timeframe (48 to 72 hours). Using a 5-mm cut-off, the prevalence rate of positive tuberculin skin test results was 31.0% (95% confidence interval 23.8% to 38.9%). Birth outside of Canada and increasing age were both predictive of a positive result. INTERPRETATION: There is a high burden of M. tuberculosis infection in this population of injection drug users. The compliance observed with returning for interpretation of skin test results indicates that successful TB screening is possible among injection drug users.  (+info)

(5/1105) Comparison between a whole blood interferon-gamma release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk for tuberculosis exposure.

A new test that measures interferon-gamma (IFN-gamma) release in whole blood following stimulation with tuberculin has the potential to detect tuberculosis infection using a single blood draw. The IFN-gamma release assay was compared with the standard tuberculin skin test (TST) among 467 intravenous drug users at risk for tuberculosis in urban Baltimore. Among 300 human immunodeficiency virus (HIV)-seronegative patients, the IFN-gamma release assay was positive in 177 (59%), whereas the TST was positive in 71 (24%), for a percent agreement of 59% (kappa=26%). Among 167 HIV-seropositive subjects, the IFN-gamma release assay identified 32 reactors (19%); the TST identified 16 reactors (9.6%), for a percent agreement of 82% (kappa=28%). The IFN-gamma release assay detected more reactors than did the TST, but its agreement with TST was weak. As the TST is an imperfect standard, further evaluation of the IFN-gamma release assay among uninfected persons and persons with culture-confirmed tuberculosis will be useful.  (+info)

(6/1105) Tuberculin skin testing among economically disadvantaged youth in a federally funded job training program.

Low income, medically underserved communities are at increased risk for tuberculosis. Limited population-based national data are available about tuberculous infection in young people from such backgrounds. To determine the prevalence of a positive tuberculin skin test among economically disadvantaged youth in a federally funded job training program during 1995 and 1996, the authors evaluated data from medical records of 22,565 randomly selected students from over 100 job training centers throughout the United States. An estimated 5.6% of students had a documented positive skin test or history of active tuberculosis. Rates were highest among those who were racial/ethnic minorities, foreign born, and (among foreign-born students) older in age (p < 0.001). Weighted rates (adjusting for sampling) were 1.3% for white, 2.2% for Native American, 4.0% for black, 9.6% for Hispanic, and 40.7% for Asian/Pacific Islander students; rates were 2.4% for US-born and 32.7% for foreign-born students. Differences by geographic region of residence were not significant after adjusting for other demographic factors. Tuberculin screening of socioeconomically disadvantaged youth such as evaluated in this study provides important sentinel surveillance data concerning groups at risk for tuberculous infection and allows recommended public health interventions to be offered.  (+info)

(7/1105) Immune responses induced in cattle by virulent and attenuated Mycobacterium bovis strains: correlation of delayed-type hypersensitivity with ability of strains to grow in macrophages.

Comparison of immune responses induced in cattle by virulent and attenuated strains of Mycobacterium bovis will assist in identifying responses associated with resistance or susceptibility to disease. Four strains of M. bovis, one which is virulent in guinea pigs (WAg201) and three which are attenuated in guinea pigs (an isoniazid-resistant strain [WAg405], ATCC 35721, and BCG) were compared for their abilities to induce immune responses in cattle and to grow in bovine lung alveolar macrophage cultures. Extensive macroscopic lesions were found only in cattle inoculated with the virulent M. bovis strain. Strong antibody responses to M. bovis culture filtrate, as well as persistently high levels of gamma interferon and interleukin-2 released from purified protein derivative (PPD)-stimulated peripheral blood lymphocyte cultures, were observed in the cattle inoculated with the virulent strain compared to those inoculated with the attenuated strains. All cattle inoculated with the virulent strain or two of the attenuated strains (WAg405 and ATCC 35721) elicited strong delayed-type hypersensitivity responses to PPD in skin tests, while animals inoculated with BCG induced only a weak response. The three strains which produced strong skin test responses proliferated well in bovine alveolar macrophages and induced high levels of proinflammatory cytokine mRNAs compared to BCG. Our study showed that skin test responsiveness to PPD correlated with the ability of the strains to grow in alveolar macrophages rather than to their pathogenicity in cattle.  (+info)

(8/1105) Safety and effectiveness of BCG vaccination in preterm babies.

AIM: To assess the cell mediated immune response to BCG vaccine in preterm babies. METHODS: Sixty two consecutive preterm babies born at < 35 weeks of gestation were randomly allocated into two groups. Babies in group A were vaccinated early at 34-35 weeks and group B were vaccinated late at 38-40 weeks of postconceptional age. The two groups were similar in terms of: gestational age (mean (SD) 33.1 (1. 1) and 33 (1.2) weeks, respectively); birthweight 1583 (204) and 1546 (218) g; neonatal problems; socioeconomic status; and postnatal weight gain. The cell mediated immune response to BCG was assessed using the Mantoux test and the lymphocyte migration inhibition test (LMIT) 6-8 weeks after BCG vaccination. Induration of >5 mm after the Mantoux test was taken as a positive response. RESULTS: There was no significant difference in the tuberculin conversion rates (80% and 80.7%, respectively), positive LMIT (86.6% and 90.3%, respectively), or BCG scar (90.0% and 87.1%, respectively) among the two groups. CONCLUSIONS: Prematurity seems to be an unlikely cause for poor vaccine uptake. Preterm babies can be effectively vaccinated with BCG at 34-35 weeks of postconceptional age, the normal time of discharge in a developing country.  (+info)



  • detection
  • Widespread bovine Tb in cattle has been diagnosed in some parts of Cameroon following comparative cervical tuberculin test, detection of Tb lesions during abattoir slaughter meat inspection, acid fast staining of bacilli, and molecular analysis of cultured isolates [ 1 , 9 , 10 ]. (hindawi.com)
  • Infection
  • Three initially QFT−/TST− women had test conversion (TST+ and/or QFT+), suggesting new infection (incidence 13.4/100 person-years). (ovid.com)
  • The test may be falsely negative within 10 weeks of infection, in those less than 6 months old, and in those who have been infected for many years. (wikipedia.org)
  • positive
  • Children less than four years of age, or children and adolescents exposed to adults in high-risk categories 15 mm or more is positive in Persons with no known risk factors for TB (Note: Targeted skin testing programs should be conducted only among high-risk groups) A tuberculin test conversion is defined as an increase of 10 mm or more within a two-day period, regardless of age. (wikipedia.org)
  • In people who develop active TB of the lungs, also called pulmonary TB, the TB skin test will often be positive. (wikipedia.org)
  • About 80% of people in many Asian and African countries test positive while 5-10% of people in the United States population test positive by the tuberculin test. (wikipedia.org)
  • After 48 to 72 hours if there is more than a five to ten millimeter area of swelling the test is considered positive. (wikipedia.org)
  • The test may be falsely positive in those who have been previously vaccinated with BCG or have been infected by other types of mycobacteria. (wikipedia.org)
  • Pregnancy
  • Lower QFT Mtb-Ag and mitogen responses in pregnancy compared with postpartum suggest that pregnancy-associated immunologic changes may influence LTBI test performance. (ovid.com)
  • reactions
  • This report describes the frequency and characteristics of serious or life-threatening hypersensitivity reactions to the tuberculin skin test over an 11-year period through November 2000. (oup.com)
  • There were 24 reports and no deaths, indicating that such reactions are rare (0.08 reported reactions per million doses of tuberculin). (oup.com)
  • dose
  • citation needed] A standard dose of 5 tuberculin units (TU - 0.1 ml), according to the CDC, or 2 TU of Statens Serum Institute (SSI) tuberculin RT23 in 0.1 ml solution, according to the NHS, is injected intradermally (between the layers of dermis) and read 48 to 72 hours later. (wikipedia.org)
  • cattle
  • This recommendation however, may require legislative action in order to make the herdsmen present their cattle for testing. (scopemed.org)
  • symptoms
  • Challenges in implementation of diagnostic algorithm for patients having symptoms suggestive of pulmonary TB with smear negative report initial sputum examination: The project is focussed on preparing a database of smear test negative patients under RNTCP in the districts of Mysore, Mandya, Chikkamangalur and Shimoga, chart out the system and patient constraints and to document the behavioural patterns of the patients for preparing a diagnostic algorithm. (wikipedia.org)
  • among
  • An indeterminate test result occurred among 6 (1.8%) of QFT-3G and 47 (14%) of TSPOT tests. (uni-muenchen.de)
  • Among 18 consistently QFT+ women, 8 (44%) converted from TST− to TST+, with improved test agreement postpartum (56.9%, κ = 0.20 to 82.4%, κ = 0.60). (ovid.com)
  • Among other people he tested tuberculin on was his mistress and later wife, Hedwig Freiberg, who was 16 years old at the time. (wikipedia.org)
  • Methods
  • Methods: A cross-sectional study was carried out at 2 HIV clinics in Atlanta to assess the utility of two IGRA tests (T-SPOT. (uni-muenchen.de)
  • usually
  • After exposure, it usually takes 8 to 10 weeks before the TB test would show if someone had become infected. (wikipedia.org)
  • articles
  • After tuberculin was on the market, articles increasingly appeared in professional publications and the public media with reports about successful treatment, to be followed by the first reports of deaths. (wikipedia.org)
  • Institute
  • He demanded that the Ministry of Culture finance an institute exclusively to produce tuberculin, and estimated the annual profit at 4.5 million marks. (wikipedia.org)
  • conversion
  • Incidence of test conversion at 6 weeks postpartum was evaluated in baseline TST−/QFT− women. (ovid.com)