The 4th cranial nerve. The trochlear nerve carries the motor innervation of the superior oblique muscles of the eye.
Diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.
Traumatic injuries to the TROCHLEAR NERVE.
The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.
A sensory branch of the trigeminal (5th cranial) nerve. The ophthalmic nerve carries general afferents from the superficial division of the face including the eyeball, conjunctiva, upper eyelid, upper nose, nasal mucosa, and scalp.
A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated with this condition include REFRACTIVE ERRORS; STRABISMUS; OCULOMOTOR NERVE DISEASES; TROCHLEAR NERVE DISEASES; ABDUCENS NERVE DISEASES; and diseases of the BRAIN STEM and OCCIPITAL LOBE.
Large endothelium-lined venous channels situated between the two layers of DURA MATER, the endosteal and the meningeal layers. They are devoid of valves and are parts of the venous system of dura mater. Major cranial sinuses include a postero-superior group (such as superior sagittal, inferior sagittal, straight, transverse, and occipital) and an antero-inferior group (such as cavernous, petrosal, and basilar plexus).
An idiopathic syndrome characterized by the formation of granulation tissue in the anterior cavernous sinus or superior orbital fissure, producing a painful ophthalmoplegia. (Adams et al., Principles of Neurology, 6th ed, p271)
One of three principal openings in the SUBARACHNOID SPACE. They are also known as cerebellomedullary cistern, and collectively as cisterns.
Paralysis of one or more of the ocular muscles due to disorders of the eye muscles, neuromuscular junction, supporting soft tissue, tendons, or innervation to the muscles.
The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris.
Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
An irregularly shaped venous space in the dura mater at either side of the sphenoid bone.
The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain.
The articulation between the articular surface of the PATELLA and the patellar surface of the FEMUR.
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.
Displacement of the PATELLA from the femoral groove.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
The flat, triangular bone situated at the anterior part of the KNEE.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Posterior fossa epithelial cyst: case report and review of the literature. (1/42)

A 49-year old woman with progressive cranial nerve signs and hemiparesis was found at MR imaging and at surgery to have a cyst at the foramen magnum. Immunohistochemistry and electron microscopy showed an epithelial cyst of endodermal origin. MR findings were of an extraaxial mass, with short T1 and T2 times. Unless immunohistochemistry and electron microscopy are used in the final diagnosis of such cysts, all posterior fossa cysts lined by a single layer of epithelium should be described simply as epithelial cysts.  (+info)

Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. (2/42)

Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn-2 in axon guidance events throughout neural development. Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerves. In addition, several major fiber tracts in the brains of adult mutant mice are either severely disorganized or missing. Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections.  (+info)

Nerve fiber composition of the intracranial portion of the oculomotor, trochlear, and abducens nerves in the sheep. (3/42)

In the present investigation, the fiber content and the diameter spectra of the intracranial portion of the three oculomotor nerves (oculomotor, trochlear, and abducens nerves) were analysed in sheep by light and electron microscopy. It was determined that up to 14.98% of fibers in the oculomotor nerve, 17.01% in the trochlear nerve, and 11.87% in the abducens nerve were unmyelinated. The myelinated fibers showed a bimodal distribution in their size spectrum in all three nerves, with a majority of large myelinated axons, but a considerable proportion of small myelinated fibers, as well. The sensory function of the unmyelinated fibers present in the three oculomotor nerves is discussed also on the basis of our previous morphofunctional investigations.  (+info)

Intracranial distribution of the sympathetic system in mice: DiI tracing and immunocytochemical labeling. (4/42)

The intracranial distribution of the cephalic branches of the superior cervical ganglion (scg) was studied in mice using indocarbocyanine dye (DiI) anterograde tracing. Two main branches were traced from the scg. The first branch joined the nerve of the pterygoid canal (the vidian nerve), npc, from which several intracranial sympathetic branches passed to the branches of the trigeminal nerve (tgn), abducent nerve (abn), trochlear nerve (trn), and oculomotor nerve (ocn). Most of the second branch joined the abn, from which sympathetic fibers dispersed in the distal region of the trigeminal ganglion (tgg) to form a plexus close to the ganglion's branches. Branches from this plexus joined the branches of the tgn, trn, and ocn. Several minor branches arising from the second branch of the scg were also observed. One formed a sympathetic plexus around the internal carotid artery (ica); a second formed a sympathetic plexus in the proximal region of tgg, close to its root; and a third branch coursed laterally to reach the ear by passing along the greater petrosal nerve (gpn). All of the intracranial trajectories traced from scg were found to be catecholaminergic, and likely sympathetic, using tyrosine hydroxylase (TH) immunocytochemistry.  (+info)

Vestibuloocular reflex of the adult flatfish. III. A species-specific reciprocal pattern of excitation and inhibition. (5/42)

In juvenile flatfish the vestibuloocular reflex (VOR) circuitry that underlies compensatory eye movements adapts to a 90 degrees relative displacement of vestibular and oculomotor reference frames during metamorphosis. VOR pathways are rearranged to allow horizontal canal-activated second-order vestibular neurons in adult flatfish to control extraocular motoneurons innervating vertical eye muscles. This study describes the anatomy and physiology of identified flatfish-specific excitatory and inhibitory vestibular pathways. In antidromically identified oculomotor and trochlear motoneurons, excitatory postsynaptic potentials (EPSPs) were elicited after electrical stimulation of the horizontal canal nerve expected to provide excitatory input. Electrotonic depolarizations (0.8-0.9 ms) preceded small amplitude (<0.5 mV) chemical EPSPs at 1.2-1.6 ms with much larger EPSPs (>1 mV) recorded around 2.5 ms. Stimulation of the opposite horizontal canal nerve produced inhibitory postsynaptic potentials (IPSPs) at a disynaptic latency of 1.6-1.8 ms that were depolarizing at membrane resting potentials around -60 mV. Injection of chloride ions increased IPSP amplitude, and current-clamp analysis showed the IPSP equilibrium potential to be near the membrane resting potential. Repeated electrical stimulation of either the excitatory or inhibitory horizontal canal vestibular nerve greatly increased the amplitude of the respective synaptic responses. These observations suggest that the large terminal arborizations of each VOR neuron imposes an electrotonic load requiring multiple action potentials to maximize synaptic efficacy. GABA antibodies labeled axons in the medial longitudinal fasciculus (MLF) some of which were hypothesized to originate from horizontal canal-activated inhibitory vestibular neurons. GABAergic terminal arborizations were distributed largely on the somata and proximal dendrites of oculomotor and trochlear motoneurons. These findings suggest that the species-specific horizontal canal inhibitory pathway exhibits similar electrophysiological and synaptic transmitter profiles as the anterior and posterior canal inhibitory projections to oculomotor and trochlear motoneurons. Electron microscopy showed axosomatic and axodendritic synaptic endings containing spheroidal synaptic vesicles to establish chemical excitatory synaptic contacts characterized by asymmetrical pre/postsynaptic membrane specializations as well as gap junctional contacts consistent with electrotonic coupling. Another type of axosomatic synaptic ending contained pleiomorphic synaptic vesicles forming chemical, presumed inhibitory, synaptic contacts on motoneurons that never included gap junctions. Altogether these data provide electrophysiological, immunohistochemical, and ultrastructural evidence for reciprocal excitatory/inhibitory organization of the novel vestibulooculomotor projections in adult flatfish. The appearance of unique second-order vestibular neurons linking the horizontal canal to vertical oculomotor neurons suggests that reciprocal excitation and inhibition are a fundamental, developmentally linked trait of compensatory eye movement circuits in vertebrates.  (+info)

Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8. (6/42)

Formation of the trochlear nerve within the anterior hindbrain provides a model system to study a simple axonal projection within the vertebrate central nervous system. We show that trochlear motor neurons are born within the isthmic organiser and also immediately posterior to it in anterior rhombomere 1. Axons of the most anterior cells follow a dorsal projection, which circumnavigates the isthmus, while those of more posterior trochlear neurons project anterodorsally to enter the isthmus. Once within the isthmus, axons form large fascicles that extend to a dorsal exit point. We investigated the possibility that the projection of trochlear axons towards the isthmus and their subsequent growth within that tissue might depend upon chemoattraction. We demonstrate that both isthmic tissue and Fgf8 protein are attractants for trochlear axons in vitro, while ectopic Fgf8 causes turning of these axons away from their normal routes in vivo. Both inhibition of FGF receptor activation and inhibition of Fgf8 function in vitro affect formation of the trochlear projection within explants in a manner consistent with a guidance function of Fgf8 during trochlear axon navigation.  (+info)

The contractile properties of slow muscle fibres in sheep extraocular muscle. (7/42)

1. The diameters of nerve fibres in the sheep trochlear nerve were measured and they fell into two distinct groups. 2. Selective stimulation of the small diameter group of nerve fibres gave rise to a slow contraction of the superior oblique muscle which was attributed to multiply innervated muscle fibres. 3. The slow fibre contraction following a single stimulus to the small diameter nerves had a rise time of 20-50 msec and was 150-980 mg in size. On repetitive stimulation, a maximum slow fibre contraction was developed at 120-140 Hz, and maximum velocity of tension development at 170-200 Hz. 4. The maximum slow fibre tetanic tension was 7-0-12-3 g, which amounted to 5-3% of the whole muscle tetanic tension, while the maximum contracture following an injection of suxamethonium was 7% of the whole muscle tetanic tension. 5. The slow fibres were very resistant to fatigue and their contraction increased the resistance of the muscle to stretching. 6. Discrepancies from earlier work and the possible significance of the slow fibres are discussed.  (+info)

Neurotization of oculomotor, trochlear and abducent nerves in skull base surgery. (8/42)

OBJECTIVE: To anatomically reconstruct the oculomotor nerve, trochlear nerve, and abducent nerve by skull base surgery. METHODS: Seventeen cranial nerves (three oculomotor nerves, eight trochlear nerves and six abducent nerves) were injured and anatomically reconstructed in thirteen skull base operations during a period from 1994 to 2000. Repair techniques included end-to-end neurosuture or fibrin glue adhesion, graft neurosuture or fibrin glue adhesion. The relationships between repair techniques and functional recovery and the related factors were analyzed. RESULTS: Functional recovery began from 3 to 8 months after surgery. During a follow-up period of 4 months to 6 years, complete recovery of function was observed in 6 trochlear nerves (75%) and 4 abducent nerves (67%), while partial functional recovery was observed in the other cranial nerves including 2 trochlear nerves, 2 abducent nerves, and 3 oculomotor nerves. CONCLUSIONS: Complete or partial functional recovery could be expected after anatomical neurotization of an injured oculomotor, trochlear or abducent nerve. Our study demonstrated that, in terms of functional recovery, trochlear and abducent nerves are more responsive than oculomotor nerves, and that end-to-end reconstruction is more efficient than graft reconstruction. These results encourage us to perform reconstruction for a separated cranial nerve as often as possible during skull base surgery.  (+info)

The trochlear nerve, also known as the fourth cranial nerve (CN IV), is a nerve that originates in the midbrain and innervates the superior oblique muscle of the eye. This muscle helps with the downward and outward movement of the eye, playing a crucial role in controlling eye movements and maintaining binocular vision. The trochlear nerve's main function is to provide motor (efferent) innervation to the superior oblique muscle, enabling fine-tuning of eye movements during activities such as reading, writing, or driving. Damage to this nerve can result in vertical diplopia (double vision), strabismus (eye misalignment), and other visual impairments.

The trochlear nerve, also known as the fourth cranial nerve (CN IV), is responsible for controlling the movement of the eye. It innervates the superior oblique muscle, which helps in depressing and rotating the eye downwards and outwards. Trochlear nerve diseases refer to conditions that affect this nerve and impair its function, leading to symptoms such as double vision (diplopia), vertical misalignment of the eyes, and difficulty with depth perception.

Trochlear nerve diseases can be caused by various factors, including trauma, compression, inflammation, infection, or tumors. Some common conditions that affect the trochlear nerve include:

1. Trochlear nerve palsy: This is a weakness or paralysis of the trochlear nerve, which can cause vertical and torsional diplopia, especially when looking downwards or to the side. It can be congenital or acquired due to trauma, compression, or other causes.
2. Aneurysm: Aneurysms in the vicinity of the trochlear nerve can compress or damage it, leading to palsy and diplopia.
3. Meningitis: Inflammation of the meninges (the membranes surrounding the brain and spinal cord) due to infection or other causes can affect the trochlear nerve and cause palsy.
4. Multiple sclerosis (MS): This is a chronic autoimmune disease that affects the central nervous system, including the cranial nerves. MS can cause demyelination of the trochlear nerve, leading to palsy and diplopia.
5. Diabetes: People with diabetes are at risk of developing diabetic neuropathy, which can affect any peripheral nerve, including the trochlear nerve.
6. Tumors: Space-occupying lesions in the brain or skull base, such as meningiomas, schwannomas, or pituitary adenomas, can compress the trochlear nerve and cause palsy.

The diagnosis of trochlear nerve diseases involves a thorough neurological examination, including assessment of eye movements and alignment. Imaging studies such as MRI or CT scans may be ordered to identify any structural lesions causing compression or damage to the nerve. Treatment depends on the underlying cause and may involve surgical intervention, medication, or observation.

A Trochlear nerve injury, also known as Fourth cranial nerve palsy, refers to damage or dysfunction of the fourth cranial nerve (trochlear nerve). This nerve is responsible for controlling the movement of the eye's superior oblique muscle, which helps in downward and outward movement of the eye.

Trochlear nerve injuries can result in vertical diplopia (double vision), where images appear double when looking downwards or to the side. The diplopia may be worse when looking down and out, such as when walking down stairs or reading.

The injury can be caused by various factors including head trauma, increased intracranial pressure, tumors, aneurysms, or other neurological conditions. Treatment options depend on the severity and cause of the injury and may include eye patches, prism lenses, or surgical intervention in some cases.

The abducens nerve, also known as the sixth cranial nerve (CN VI), is a motor nerve that controls the lateral rectus muscle of the eye. This muscle is responsible for moving the eye away from the midline (towards the temple) and enables the eyes to look towards the side while keeping them aligned. Any damage or dysfunction of the abducens nerve can result in strabismus, where the eyes are misaligned and point in different directions, specifically an adduction deficit, also known as abducens palsy or sixth nerve palsy.

The ophthalmic nerve, also known as the first cranial nerve or CN I, is a sensory nerve that primarily transmits information about vision, including light intensity and color, and sensation in the eye and surrounding areas. It is responsible for the sensory innervation of the upper eyelid, conjunctiva, cornea, iris, ciliary body, and nasal cavity. The ophthalmic nerve has three major branches: the lacrimal nerve, frontal nerve, and nasociliary nerve. Damage to this nerve can result in various visual disturbances and loss of sensation in the affected areas.

Diplopia is a medical term that refers to the condition where a person sees two images of a single object. It is commonly known as double vision. This can occur due to various reasons, such as nerve damage or misalignment of the eyes. Diplopia can be temporary or chronic and can affect one or both eyes. If you're experiencing diplopia, it's essential to consult an eye care professional for proper evaluation and treatment.

Cranial sinuses are a part of the venous system in the human head. They are air-filled spaces located within the skull and are named according to their location. The cranial sinuses include:

1. Superior sagittal sinus: It runs along the top of the brain, inside the skull, and drains blood from the scalp and the veins of the brain.
2. Inferior sagittal sinus: It runs along the bottom of the brain and drains into the straight sinus.
3. Straight sinus: It is located at the back of the brain and receives blood from the inferior sagittal sinus and great cerebral vein.
4. Occipital sinuses: They are located at the back of the head and drain blood from the scalp and skull.
5. Cavernous sinuses: They are located on each side of the brain, near the temple, and receive blood from the eye and surrounding areas.
6. Sphenoparietal sinus: It is a small sinus that drains blood from the front part of the brain into the cavernous sinus.
7. Petrosquamosal sinuses: They are located near the ear and drain blood from the scalp and skull.

The cranial sinuses play an essential role in draining blood from the brain and protecting it from injury.

Tolosa-Hunt syndrome is a rare disorder characterized by the inflammation of the nerve structures (including the fifth and sixth cranial nerves) within the cavernous sinus, a venous space near the base of the skull. This inflammation can lead to various symptoms such as:

1. Unilateral or bilateral orbital pain, which may be severe and deep, often radiating around the eye and temple.
2. Ophthalmoplegia (paralysis of the eye muscles), causing double vision (diplopia) and limited eye movement in specific directions.
3. Ptosis (drooping of the eyelid).
4. Other possible symptoms include decreased sensation around the forehead, cheek, or upper jaw, and loss of taste on the anterior part of the tongue.

The exact cause of Tolosa-Hunt syndrome is unknown, but it's believed to be related to an autoimmune response or a non-specific inflammatory process. It can also occur in conjunction with other medical conditions like neoplasms (tumors) or infections. The diagnosis typically involves imaging studies such as MRI and CT scans, along with blood tests and a thorough neurological examination.

Treatment usually includes corticosteroids to reduce inflammation and alleviate symptoms. In some cases, immunosuppressive medications or radiation therapy may be necessary. If left untreated, Tolosa-Hunt syndrome can lead to permanent visual impairment or other neurological deficits.

The term "cisterna magna" is derived from Latin, where "cisterna" means "reservoir" or "receptacle," and "magna" means "large." In medical anatomy, the cisterna magna refers to a large, sac-like space located near the lower part of the brainstem. It is a subarachnoid cistern, which means it is a space that contains cerebrospinal fluid (CSF) between the arachnoid and pia mater membranes covering the brain and spinal cord.

More specifically, the cisterna magna is situated between the cerebellum (the lower part of the brain responsible for coordinating muscle movements and maintaining balance) and the occipital bone (the bone at the back of the skull). This space contains a significant amount of CSF, which serves as a protective cushion for the brain and spinal cord, helps regulate intracranial pressure, and facilitates the circulation of nutrients and waste products.

The cisterna magna is an essential structure in neurosurgical procedures and diagnostic imaging techniques like lumbar puncture (spinal tap) or myelograms, where contrast agents are introduced into the CSF to visualize the spinal cord and surrounding structures. Additionally, it serves as a crucial landmark for various surgical approaches to the posterior fossa (the lower part of the skull that houses the cerebellum and brainstem).

Ophthalmoplegia is a medical term that refers to the paralysis or weakness of the eye muscles, which can result in double vision (diplopia) or difficulty moving the eyes. It can be caused by various conditions, including nerve damage, muscle disorders, or neurological diseases such as myasthenia gravis or multiple sclerosis. Ophthalmoplegia can affect one or more eye muscles and can be partial or complete. Depending on the underlying cause, ophthalmoplegia may be treatable with medications, surgery, or other interventions.

The oculomotor muscles are a group of extraocular muscles that control the movements of the eye. They include:

1. Superior rectus: This muscle is responsible for elevating the eye and helping with inward rotation (intorsion) when looking downwards.
2. Inferior rectus: It depresses the eye and helps with outward rotation (extorsion) when looking upwards.
3. Medial rectus: This muscle adducts, or moves, the eye towards the midline of the face.
4. Inferior oblique: The inferior oblique muscle intorts and elevates the eye.
5. Superior oblique: It extorts and depresses the eye.

These muscles work together to allow for smooth and precise movements of the eyes, enabling tasks such as tracking moving objects, reading, and maintaining visual fixation on a single point in space.

Cranial nerve diseases refer to conditions that affect the cranial nerves, which are a set of 12 pairs of nerves that originate from the brainstem and control various functions in the head and neck. These functions include vision, hearing, taste, smell, movement of the eyes and face, and sensation in the face.

Diseases of the cranial nerves can result from a variety of causes, including injury, infection, inflammation, tumors, or degenerative conditions. The specific symptoms that a person experiences will depend on which cranial nerve is affected and how severely it is damaged.

For example, damage to the optic nerve (cranial nerve II) can cause vision loss or visual disturbances, while damage to the facial nerve (cranial nerve VII) can result in weakness or paralysis of the face. Other common symptoms of cranial nerve diseases include pain, numbness, tingling, and hearing loss.

Treatment for cranial nerve diseases varies depending on the underlying cause and severity of the condition. In some cases, medication or surgery may be necessary to treat the underlying cause and relieve symptoms. Physical therapy or rehabilitation may also be recommended to help individuals regain function and improve their quality of life.

The cavernous sinus is a venous structure located in the middle cranial fossa, which is a depression in the skull that houses several important nerves and blood vessels. The cavernous sinus is situated on either side of the sphenoid bone, near the base of the skull, and it contains several important structures:

* The internal carotid artery, which supplies oxygenated blood to the brain
* The abducens nerve (cranial nerve VI), which controls lateral movement of the eye
* The oculomotor nerve (cranial nerve III), which controls most of the muscles that move the eye
* The trochlear nerve (cranial nerve IV), which controls one of the muscles that moves the eye
* The ophthalmic and maxillary divisions of the trigeminal nerve (cranial nerve V), which transmit sensory information from the face and head

The cavernous sinus is an important structure because it serves as a conduit for several critical nerves and blood vessels. However, it is also vulnerable to various pathological conditions such as thrombosis (blood clots), infection, tumors, or aneurysms, which can lead to serious neurological deficits or even death.

The oculomotor nerve, also known as the third cranial nerve (CN III), is a motor nerve that originates from the midbrain. It controls the majority of the eye muscles, including the levator palpebrae superioris muscle that raises the upper eyelid, and the extraocular muscles that enable various movements of the eye such as looking upward, downward, inward, and outward. Additionally, it carries parasympathetic fibers responsible for pupillary constriction and accommodation (focusing on near objects). Damage to this nerve can result in various ocular motor disorders, including strabismus, ptosis, and pupillary abnormalities.

The patellofemoral joint is the articulation between the patella (kneecap) and the femur (thigh bone). It is a synovial joint, which means it is surrounded by a joint capsule containing synovial fluid to lubricate the joint. This joint is responsible for providing stability to the knee extensor mechanism and allows for smooth movement of the patella during activities like walking, running, and jumping. Pain or dysfunction in this joint can result in various conditions such as patellofemoral pain syndrome, chondromalacia patella, or patellar dislocation.

Neuroimaging is a medical term that refers to the use of various techniques to either directly or indirectly image the structure, function, or pharmacology of the nervous system. It includes techniques such as computed tomography (CT), magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and diffusion tensor imaging (DTI). These techniques are used to diagnose and monitor various neurological and psychiatric conditions, as well as to understand the underlying mechanisms of brain function in health and disease.

The mesencephalon, also known as the midbrain, is the middle portion of the brainstem that connects the hindbrain (rhombencephalon) and the forebrain (prosencephalon). It plays a crucial role in several important functions including motor control, vision, hearing, and the regulation of consciousness and sleep-wake cycles. The mesencephalon contains several important structures such as the cerebral aqueduct, tectum, tegmentum, cerebral peduncles, and several cranial nerve nuclei (III and IV).

Patellar dislocation is a medical condition characterized by the displacement of the patella (kneecap) from its normal position in the femoral groove, which is a part of the femur (thighbone). This displacement usually occurs laterally, meaning that the patella moves toward the outer side of the knee.

Patellar dislocation can happen as a result of direct trauma or due to various factors that increase the laxity of the medial patellofemoral ligament and tightness of the lateral structures, leading to abnormal tracking of the patella. These factors include anatomical variations, muscle imbalances, genetic predisposition, or degenerative changes in the knee joint.

Dislocation of the patella can cause pain, swelling, and difficulty in moving the knee. In some cases, it might be associated with other injuries such as fractures or damage to the articular cartilage and surrounding soft tissues. Immediate medical attention is required for proper diagnosis and treatment, which may involve reduction, immobilization, physical therapy, bracing, or even surgery in severe cases.

The sciatic nerve is the largest and longest nerve in the human body, running from the lower back through the buttocks and down the legs to the feet. It is formed by the union of the ventral rami (branches) of the L4 to S3 spinal nerves. The sciatic nerve provides motor and sensory innervation to various muscles and skin areas in the lower limbs, including the hamstrings, calf muscles, and the sole of the foot. Sciatic nerve disorders or injuries can result in symptoms such as pain, numbness, tingling, or weakness in the lower back, hips, legs, and feet, known as sciatica.

The patella, also known as the kneecap, is a sesamoid bone located at the front of the knee joint. It is embedded in the tendon of the quadriceps muscle and serves to protect the knee joint and increase the leverage of the extensor mechanism, allowing for greater extension force of the lower leg. The patella moves within a groove on the femur called the trochlea during flexion and extension of the knee.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

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