Fungal infection of keratinized tissues such as hair, skin and nails. The main causative fungi include MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON.
Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum.
Ringworm of the scalp and associated hair mainly caused by species of MICROSPORUM; TRICHOPHYTON; and EPIDERMOPHYTON, which may occasionally involve the eyebrows and eyelashes.
A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions, and is caused by Pityrosporon orbiculare. (Dorland, 27th ed)
A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair.
A fungal genus which grows in the epidermis and is the cause of TINEA.
A disease of the scalp that may affect the glabrous skin and the nails and is recognized by the concave sulfur-yellow crusts that form around loose, wiry hairs. Atrophy ensues, leaving a smooth, glossy, thin, paper-white patch. This type of disease is rare in the United States and more frequently seen in the Middle East, Africa, Southeastern Europe, and other countries bordering the Mediterranean Sea. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p319)
An antifungal agent used in the treatment of TINEA infections.
A fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS.
A mitosporic Oxygenales fungal genus causing various diseases of the skin and hair. The species Microsporum canis produces TINEA CAPITIS and tinea corporis, which usually are acquired from domestic cats and dogs. Teleomorphs includes Arthroderma (Nannizzia). (Alexopoulos et al., Introductory Mycology, 4th edition, p305)
Skin diseases of the foot, general or unspecified.
Superficial infections of the skin or its appendages by any of various fungi.
A family of ascomycetous fungi, order Onygenales, characterized by smooth ascospores. Genera in the family include Arthroderma, Keratinomyces, and Ctenomyces. Several well-known anamorphic forms are parasitic upon the skin.
Hand dermatoses is a general term referring to various inflammatory skin conditions primarily affecting the hands, such as eczema, psoriasis, and contact dermatitis, characterized by erythema, scaling, vesiculation, fissuring, or lichenification.
A mitosporic fungal genus that causes a variety of skin disorders. Malassezia furfur (Pityrosporum orbiculare) causes TINEA VERSICOLOR.
Inanimate objects that carry pathogenic microorganisms and thus can serve as the source of infection. Microorganisms typically survive on fomites for minutes or hours. Common fomites include CLOTHING, tissue paper, hairbrushes, and COOKING AND EATING UTENSILS.
Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)
A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
A sport consisting of hand-to-hand combat between two unarmed contestants seeking to pin or press each other's shoulders to the ground.

Species identification and strain differentiation of dermatophyte fungi by analysis of ribosomal-DNA intergenic spacer regions. (1/152)

Restriction fragment length polymorphisms (RFLPs) identified in the ribosomal-DNA (rDNA) repeat were used for molecular strain differentiation of the dermatophyte fungus Trichophyton rubrum. The polymorphisms were detected by hybridization of EcoRI-digested T. rubrum genomic DNAs with a probe amplified from the small-subunit (18S) rDNA and adjacent internal transcribed spacer (ITS) regions. The rDNA RFLPs mapped to the nontranscribed spacer (NTS) region of the rDNA repeat and appeared similar to those caused by short repetitive sequences in the intergenic spacers of other fungi. Fourteen individual RFLP patterns (DNA types A to N) were recognized among 50 random clinical isolates of T. rubrum. A majority of strains (19 of 50 [38%]) were characterized by one RFLP pattern (DNA type A), and four types (DNA types A to D) accounted for 78% (39 of 50) of all strains. The remaining types (DNA types E to N) were represented by one or two isolates only. A rapid and simple method was also developed for molecular species identification of dermatophyte fungi. The contiguous ITS and 5.8S rDNA regions were amplified from 17 common dermatophyte species by using the universal primers ITS 1 and ITS 4. Digestion of the amplified ITS products with the restriction endonuclease MvaI produced unique and easily identifiable fragment patterns for a majority of species. However, some closely related taxon pairs, such as T. rubrum-T. soudanense and T. quinkeanum-T. schoenlenii could not be distinguished. We conclude that RFLP analysis of the NTS and ITS intergenic regions of the rDNA repeat is a valuable technique both for molecular strain differentiation of T. rubrum and for species identification of common dermatophyte fungi.  (+info)

The antifungal activity of mupirocin. (2/152)

The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amino acids and precursors of RNA, but not that of acetate, by Trichophyton mentagrophytes. It also inhibited the isoleucyl-tRNA synthetase from Candida albicans, indicating a mechanism of action similar to that in bacteria. When administered topically, mupirocin was efficacious in a T. mentagrophytes ringworm model in guinea pigs. These results suggest that mupirocin could have clinical utility for superficial infections caused by dermatophytes.  (+info)

Molecular markers reveal exclusively clonal reproduction in Trichophyton rubrum. (3/152)

Genotypic variability among 96 Trichophyton rubrum strains which displayed different colony morphologies and were collected from four continents was investigated. Twelve markers representing 57 loci were analyzed by PCR fingerprinting, amplified fragment length polymorphism, and random amplified monomorphic DNA markers. Interestingly, none of the methods used revealed any DNA polymorphism, indicating a strictly clonal mode of reproduction and a strong adaptation to human skin.  (+info)

Dermatophytosis: association between ABO blood groups and reactivity to the trichophytin. (4/152)

The authors investigated the relationship between dermatophytosis and ABO blood groups through blood typing, identification of isolated dermatophytes and specific cellular immune response of 40 individuals carriers of this mycosis. They verified that the fungus Trichophyton rubrum, isolated from 54.5% of the patients, was more frequent in individuals belonging to blood group A. The cellular immune response, evaluated through the trichophytin antigen, was positive in 25% of the studied patients; the presence of immediate reactions (30 minutes) was verified in 35%. The blood group distribution among patients with dermatophytosis and control groups was, respectively: 47.5% X 36% in group A, 40% X 50% in group O, 12. 5% X 11% in group B. Even though the authors have found a higher number of patients belonging to blood group A infected by T. rubrum, these results suggest that there is no statistical evidence that these individuals are more susceptible to dermatophytosis.  (+info)

Dermatophytosis caused by Trichophyton raubitschekii. Report of the first case in Sao Paulo, Brazil. (5/152)

The authors report the first case of dermatophytosis caused by Trichophyton raubitschekii in a patient from the State of Sao Paulo with Tinea corporis lesions localized on the buttocks. Culture on Sabouraud-agar with cycloheximide permitted the isolation and identification of the fungus, and the diagnosis was confirmed by Dr. Lynne Sigler, University of Alberta, Canada. Systemic treatment with fluconazole, 150 mg/week for 4 weeks, in combination with topical treatment with isoconazole initially yielded favorable results, with recurrence of the lesions after the medication was discontinued. This is the fifth case of this dermatophytosis published in the Brazilian medical literature.  (+info)

Diagnosing dermatomycosis in general practice. (6/152)

BACKGROUND: Diagnosing dermatomycosis from a clinical image is not always easy. Microscopy of a potassium hydroxide preparation (KOH-test) and culturing are seldomly used in general practice. Cyanoacrylate surface skin scraping (CSSS) is a new diagnostic tool that may be useful and simple. OBJECTIVES: We aimed to investigate the diagnostic value of signs and symptoms, the KOH-test and the CSSS, in patients with erythematosquamous skin lesions, using the culture as the gold standard. Our goal is to formulate an optimal algorithm for the diagnosis of mycosis, based on one or more of these tests and including both optimal accuracy and costs. METHODS: Scales from 148 consecutive general practice patients were tested using a KOH-test, CSSS and culture. Clinical data were collected using a questionnaire. RESULTS: Twenty-six (18%) positive fungal cultures were identified. The sensitivity of the clinical diagnosis was 81% and its specificity 45%; for the KOH-test, these figures were 12 and 93% respectively; and for the CSSS, 62 and 88%, respectively. The positive predictive value of the clinical diagnosis was 24% and the negative predictive value 92%; for the KOH-test these figures were 25 and 83%, respectively, and for the CSSS, 52 and 92%, respectively. Determining CSSS in all patients proved to be the most accurate policy (accuracy = 83%). The likelihood ratio of CSSS in all patients was 5.17 for a positive test result and 0.43 for a negative test result. An approach in which CSSS is obtained in only those patients whom the physician considers by clinical examination to have dermatomycosis, with no testing in other patients, results in positive and negative likelihood ratios of 4.69 and 0.56, respectively. Such a policy would result in an overall sensitivity of 50%, a specificity of 89%, a positive predictive value of 50% and a negative predictive value of 89%. DISCUSSION: The clinical picture of dermatomycosis is not very reliable. The combination of a clinical judgement if this is negative and an additional CSSS in the case of a positive clinical judgement provides us with the best cost-benefit ratio, if both diagnostic accuracy and logistic considerations are taken into consideration.  (+info)

Fluorometric assessment of In vitro antidermatophytic activities of antimycotics based on their keratin-penetrating power. (7/152)

Keratin particles impregnated with amorolfine or clotrimazole in serial doubling dilutions (64 to 0.125 microg/ml) were used to evaluate the activities of these agents against 20 isolates each of Trichophyton mentagrophytes and Trichophyton rubrum in a yeast carbon broth medium incorporating Alamar Blue dye. The proposed MIC with keratin impregnation (MIC(K)) is defined as the lowest concentration of an agent used to impregnate keratin particles that effects a fluorescence-based fungal growth quotient of 0.05 or less. The conventional colorimetric and visual MICs of amorolfine for the dermatophytes, 64 microg/ml] and 64 microg/ml [range, 16 to >64 microg], respectively) may indicate the strong in vivo antidermatophytic activity of amorolfine as a topical agent. The new antidermatophytic susceptibility testing procedure has potential clinical utility for the in vitro screening of agents for use in the topical treatment of superficial mycoses.  (+info)

Molecular taxonomy of the Trichophyton rubrum complex. (8/152)

The validity of taxa around Trichophyton rubrum was evaluated by a combination of phenetic and molecular methods. Morphological and physiological features were compared to results of sequencing of the internal transcribed spacer region of the ribosomal operon, PCR fingerprinting, and amplified fragment length polymorphism analysis. The 15 species and varieties investigated (Trichophyton circonvolutum, Trichophyton fischeri, Trichophyton fluviomuniense, Trichophyton glabrum, Trichophyton gourvilii, Trichophyton kanei, Trichophyton kuryangei, Trichophyton megninii, Trichophyton pedis, Trichophyton raubitschekii, Trichophyton rodhaini, Trichophyton rubrum var. nigricans, Trichophyton soudanense, Trichophyton violaceum var. indicum, and Trichophyton yaoundei) were reclassified or synonymized as T. rubrum or T. violaceum.  (+info)

Tinea is a common fungal infection of the skin, also known as ringworm. It's called ringworm because of its characteristic red, circular, and often scaly rash with raised edges that can resemble a worm's shape. However, it has nothing to do with any kind of actual worm.

The fungi responsible for tinea infections belong to the genus Trichophyton, Microsporum, or Epidermophyton. These fungi thrive in warm, damp environments and can be contracted from infected people, animals, or contaminated soil. Common types of tinea infections include athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm of the scalp (tinea capitis).

Treatment for tinea typically involves antifungal medications, either topical or oral, depending on the location and severity of the infection. Proper hygiene and avoiding sharing personal items can help prevent the spread of this contagious condition.

Tinea Pedis, also known as athlete's foot, is a fungal infection that affects the skin on the feet, particularly between the toes. The causative agents are dermatophytes, which thrive in warm and damp environments. Common symptoms include itching, burning, cracked, blistered, or scaly skin, and sometimes painful peeling or cracking of the skin. It is contagious and can spread to other parts of the body or to other people through direct contact or via contaminated surfaces. Proper hygiene, keeping the feet dry, and using antifungal medications are common methods of preventing and treating this condition.

Tinea capitis is a dermatophyte infection, primarily affecting the scalp and hair. It is commonly known as "ringworm of the scalp." The term "ringworm" is a misnomer because it has nothing to do with worms; instead, it refers to the ring-like appearance of the rash caused by these fungi.

The infection is more prevalent in children than adults and can spread through direct contact with an infected person or animal (like pets), or via contaminated objects such as combs, brushes, hats, etc. The causative agents are typically mold-like fungi called dermatophytes, which belong to the genera Microsporum or Trichophyton.

Symptoms of tinea capitis include itchiness, scaling, hair loss (in patches), and the presence of black dots on the scalp where broken hairs remain. In some cases, inflammation and pustules may occur. Diagnosis is usually confirmed through microscopic examination of hair or scale samples, and sometimes by culture.

Treatment typically involves oral antifungal medications like griseofulvin, terbinafine, itraconazole, or fluconazole for several weeks to ensure complete eradication of the fungus. Topical antifungals are often used in conjunction with oral therapy. Good hygiene practices and avoiding sharing personal items can help prevent transmission.

Tinea versicolor is a superficial fungal infection of the skin, caused by the pathogen Malassezia furfur (previously known as Pityrosporum ovale). It is characterized by the appearance of multiple round or oval patches that are hypopigmented (lighter than the surrounding skin) or hyperpigmented (darker than the surrounding skin), scaly, and can be pruritic (itchy). The lesions typically appear on the trunk and proximal extremities, often in a symmetrical pattern. Tinea versicolor is more common in warm, humid climates and in individuals with oily skin or weakened immune systems. It is usually diagnosed based on the clinical presentation and can be confirmed by microscopic examination of skin scrapings or fungal cultures. Treatment typically involves topical antifungal medications, such as clotrimazole, miconazole, or selenium sulfide, but oral medication may be necessary for severe or widespread infections.

Trichophyton is a genus of fungi that are primarily responsible for causing various superficial and cutaneous infections in humans and animals. These infections, known as dermatophytoses or ringworm, typically involve the skin, hair, and nails. Some common examples of diseases caused by Trichophyton species include athlete's foot (T. rubrum), jock itch (T. mentagrophytes), and scalp ringworm (T. tonsurans).

The fungi in the Trichophyton genus are called keratinophilic, meaning they have a preference for keratin, a protein found in high concentrations in skin, hair, and nails. This characteristic allows them to thrive in these environments and cause infection. The specific species of Trichophyton involved in an infection will determine the clinical presentation and severity of the disease.

In summary, Trichophyton is a medical term referring to a group of fungi that can cause various skin, hair, and nail infections in humans and animals.

'Epidermophyton' is a genus of fungi that can cause skin and nail infections in humans. These types of infections are known as dermatophytoses or ringworm infections. The most common species that infect humans is Epidermophyton floccosum, which tends to cause infections of the feet (athlete's foot), nails, and groin (jock itch).

Epidermophyton fungi thrive on keratin, a protein found in skin, hair, and nails. They invade the dead outer layers of the skin or nails, causing inflammation, itching, scaling, and other symptoms. The infections can be spread through direct contact with an infected person or contaminated objects like towels, shoes, or floors.

To diagnose an Epidermophyton infection, a healthcare professional may collect a sample from the affected area and examine it under a microscope for the presence of fungal elements. The diagnosis can also be confirmed through culture methods, where the sample is grown on specialized media to identify the specific fungal species.

Treatment for Epidermophyton infections typically involves topical or oral antifungal medications, depending on the severity and location of the infection. Preventive measures such as keeping the skin clean and dry, avoiding sharing personal items, and wearing breathable footwear can help reduce the risk of contracting and spreading these types of infections.

Tinea favosa, also known as "black dot ringworm," is a chronic and severe form of tinea capitis (ringworm of the scalp). It is caused by the fungus Trichophyton schoenleinii. The name "black dot" refers to the appearance of hair shafts that become broken off at the skin surface, leaving small black dots on the scalp.

The infection often affects children and can cause scaling, alopecia (hair loss), and formation of kerion (a severely inflamed and pustular lesion). The condition is highly contagious and can spread through contact with infected individuals or contaminated objects such as combs, brushes, hats, and towels.

Tinea favosa can be challenging to treat due to its chronic nature and the development of extensive scarring and permanent hair loss if left untreated. Treatment typically involves oral antifungal medications for an extended period, along with proper hygiene measures to prevent the spread of infection.

Griseofulvin is an antifungal medication used to treat various fungal infections, including those affecting the skin, hair, and nails. It works by inhibiting the growth of fungi, particularly dermatophytes, which cause these infections. Griseofulvin can be obtained through a prescription and is available in oral (by mouth) and topical (on the skin) forms.

The primary mechanism of action for griseofulvin involves binding to tubulin, a protein necessary for fungal cell division. This interaction disrupts the formation of microtubules, which are crucial for the fungal cell's structural integrity and growth. As a result, the fungi cannot grow and multiply, allowing the infected tissue to heal and the infection to resolve.

Common side effects associated with griseofulvin use include gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea), headache, dizziness, and skin rashes. It is essential to follow the prescribing physician's instructions carefully when taking griseofulvin, as improper usage may lead to reduced effectiveness or increased risk of side effects.

It is important to note that griseofulvin has limited use in modern medicine due to the development of newer and more effective antifungal agents. However, it remains a valuable option for specific fungal infections, particularly those resistant to other treatments.

Onychomycosis is a medical term that refers to a fungal infection in the nails (both fingernails and toenails). This condition occurs when fungi, usually dermatophytes, invade the nail bed and cause damage to the nail plate. It can lead to symptoms such as discoloration, thickening, crumbling, and separation of the nail from the nail bed. Onychomycosis can be challenging to treat and may require long-term antifungal therapy, either topical or oral, or even removal of the infected nail in severe cases.

Microsporum is a genus of fungi belonging to the family Arthrodermataceae. These fungi are known to cause various types of tinea (ringworm) infections in humans and animals. They are characterized by their ability to produce large, thick-walled macroconidia that are typically round to oval in shape.

The most common species of Microsporum that infect humans include M. canis, M. audouinii, and M. gypsum. These fungi are often found in soil and on the skin or fur of animals such as cats, dogs, and cattle. They can cause a variety of skin infections, including tinea capitis (scalp ringworm), tinea corporis (body ringworm), and tinea unguium (nail ringworm).

Microsporum infections are typically treated with topical or oral antifungal medications. Prevention measures include good personal hygiene, avoiding contact with infected animals, and prompt treatment of any fungal infections.

Foot dermatoses refer to various skin conditions that affect the feet. These can include inflammatory conditions like eczema and psoriasis, infectious diseases such as athlete's foot (tinea pedis), fungal infections, bacterial infections, viral infections (like plantar warts caused by HPV), and autoimmune blistering disorders. Additionally, contact dermatitis from irritants or allergens can also affect the feet. Proper diagnosis is essential to determine the best course of treatment for each specific condition.

Dermatomycoses are a group of fungal infections that affect the skin, hair, and nails. These infections are caused by various types of fungi, including dermatophytes, yeasts, and molds. Dermatophyte infections, also known as tinea, are the most common type of dermatomycoses and can affect different areas of the body, such as the scalp (tinea capitis), beard (tinea barbae), body (tinea corporis), feet (tinea pedis or athlete's foot), hands (tinea manuum), and nails (tinea unguium or onychomycosis). Yeast infections, such as those caused by Candida albicans, can lead to conditions like candidal intertrigo, vulvovaginitis, and balanitis. Mold infections are less common but can cause skin disorders like scalded skin syndrome and phaeohyphomycosis. Dermatomycoses are typically treated with topical or oral antifungal medications.

Arthrodermataceae is a family of fungi that includes several medically important dermatophytes, which are fungi that can cause skin and nail infections known as tinea. Some notable genera within this family include:

1. Trichophyton: This genus contains several species that can cause various types of tinea infections, such as athlete's foot (tinea pedis), ringworm (tinea corporis), and jock itch (tinea cruris). Some species can also cause nail infections (tinea unguium or onychomycosis).
2. Microsporum: This genus includes some of the less common causes of tinea infections, such as tinea capitis (scalp ringworm) and tinea corporis.
3. Epidermophyton: This genus contains species that can cause tinea infections of the feet, hands, and nails.

These fungi primarily feed on keratin, a protein found in skin, hair, and nails, and typically invade dead or damaged tissue. Infections caused by Arthrodermataceae are usually treatable with antifungal medications, either topical or oral, depending on the severity and location of the infection.

Hand dermatoses is a general term used to describe various inflammatory skin conditions that affect the hands. These conditions can cause symptoms such as redness, swelling, itching, blistering, scaling, and cracking of the skin on the hands. Common examples of hand dermatoses include:

1. Irritant contact dermatitis: A reaction that occurs when the skin comes into contact with irritants such as chemicals, soaps, or detergents.
2. Allergic contact dermatitis: A reaction that occurs when the skin comes into contact with allergens, such as nickel, rubber, or poison ivy.
3. Atopic dermatitis (eczema): A chronic skin condition characterized by dry, itchy, and inflamed skin.
4. Psoriasis: A chronic skin condition characterized by red, scaly patches that can occur anywhere on the body, including the hands.
5. Dyshidrotic eczema: A type of eczema that causes small blisters to form on the sides of the fingers, palms, and soles of the feet.
6. Lichen planus: An inflammatory skin condition that can cause purple or white patches to form on the hands and other parts of the body.
7. Scabies: A contagious skin condition caused by mites that burrow into the skin and lay eggs, causing intense itching and a rash.

Treatment for hand dermatoses depends on the specific diagnosis and may include topical creams or ointments, oral medications, phototherapy, or avoidance of triggers.

Malassezia is a genus of fungi (specifically, yeasts) that are commonly found on the skin surfaces of humans and other animals. They are part of the normal flora of the skin, but under certain conditions, they can cause various skin disorders such as dandruff, seborrheic dermatitis, pityriasis versicolor, and atopic dermatitis.

Malassezia species require lipids for growth, and they are able to break down the lipids present in human sebum into fatty acids, which can cause irritation and inflammation of the skin. Malassezia is also associated with fungal infections in people with weakened immune systems.

The genus Malassezia includes several species, such as M. furfur, M. globosa, M. restricta, M. sympodialis, and others. These species can be identified using various laboratory methods, including microscopy, culture, and molecular techniques.

Fomites are objects or materials in the environment that can carry and transmit infectious organisms, such as bacteria, viruses, and fungi. Common examples of fomites include doorknobs, handrails, clothing, bedding, and towels. When an infected person touches or coughs on a fomite, the microorganisms can be transferred to another person who comes into contact with it. It's important to practice good hygiene, such as washing hands regularly and cleaning surfaces, to reduce the spread of infections through fomites.

Cutaneous candidiasis is a fungal infection of the skin caused by Candida species, most commonly Candida albicans. The infection can occur anywhere on the skin, but it typically affects warm, moist areas such as the armpits, groin, and fingers. The symptoms of cutaneous candidiasis include redness, itching, burning, and cracking of the skin. In severe cases, pustules or blisters may also be present.

The infection can occur in people of all ages but is more common in those with weakened immune systems, such as individuals with HIV/AIDS, diabetes, or cancer. Other risk factors include obesity, poor hygiene, and the use of certain medications, such as antibiotics and corticosteroids.

Treatment for cutaneous candidiasis typically involves topical antifungal medications, such as clotrimazole or miconazole. In severe cases, oral antifungal medications may be necessary. Keeping the affected area clean and dry is also important to prevent the spread of the infection.

Intertrigo is a skin condition that occurs in warm, moist areas of the body where skin rubs together or overlaps, such as the groin, armpits, beneath the breasts, and between folds of fatty tissue. It is characterized by red, raw, itchy, or painful skin that may ooze or become scaly. Intertrigo can be caused by fungal or bacterial infections, excessive sweating, friction, or poor hygiene. Treatment typically involves keeping the affected area dry and exposed to air, using antifungal or antibacterial medications, and maintaining good personal hygiene.

Antifungal agents are a type of medication used to treat and prevent fungal infections. These agents work by targeting and disrupting the growth of fungi, which include yeasts, molds, and other types of fungi that can cause illness in humans.

There are several different classes of antifungal agents, including:

1. Azoles: These agents work by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes. Examples of azole antifungals include fluconazole, itraconazole, and voriconazole.
2. Echinocandins: These agents target the fungal cell wall, disrupting its synthesis and leading to fungal cell death. Examples of echinocandins include caspofungin, micafungin, and anidulafungin.
3. Polyenes: These agents bind to ergosterol in the fungal cell membrane, creating pores that lead to fungal cell death. Examples of polyene antifungals include amphotericin B and nystatin.
4. Allylamines: These agents inhibit squalene epoxidase, a key enzyme in ergosterol synthesis. Examples of allylamine antifungals include terbinafine and naftifine.
5. Griseofulvin: This agent disrupts fungal cell division by binding to tubulin, a protein involved in fungal cell mitosis.

Antifungal agents can be administered topically, orally, or intravenously, depending on the severity and location of the infection. It is important to use antifungal agents only as directed by a healthcare professional, as misuse or overuse can lead to resistance and make treatment more difficult.

Clotrimazole is an antifungal medication used to treat various fungal infections such as athlete's foot, jock itch, ringworm, candidiasis (yeast infection), and oral thrush. It works by inhibiting the growth of fungi that cause these infections. Clotrimazole is available in several forms, including creams, lotions, powders, tablets, and lozenges.

The medical definition of Clotrimazole is:

A synthetic antifungal agent belonging to the imidazole class, used topically to treat various fungal infections such as candidiasis, tinea pedis, tinea cruris, and tinea versicolor. It works by inhibiting the biosynthesis of ergosterol, a key component of fungal cell membranes, leading to increased permeability and death of fungal cells.

Topical administration refers to a route of administering a medication or treatment directly to a specific area of the body, such as the skin, mucous membranes, or eyes. This method allows the drug to be applied directly to the site where it is needed, which can increase its effectiveness and reduce potential side effects compared to systemic administration (taking the medication by mouth or injecting it into a vein or muscle).

Topical medications come in various forms, including creams, ointments, gels, lotions, solutions, sprays, and patches. They may be used to treat localized conditions such as skin infections, rashes, inflammation, or pain, or to deliver medication to the eyes or mucous membranes for local or systemic effects.

When applying topical medications, it is important to follow the instructions carefully to ensure proper absorption and avoid irritation or other adverse reactions. This may include cleaning the area before application, covering the treated area with a dressing, or avoiding exposure to sunlight or water after application, depending on the specific medication and its intended use.

Naphthalene is not typically referred to as a medical term, but it is a chemical compound with the formula C10H8. It is a white crystalline solid that is aromatic and volatile, and it is known for its distinctive mothball smell. In a medical context, naphthalene is primarily relevant as a potential toxin or irritant.

Naphthalene can be found in some chemical products, such as mothballs and toilet deodorant blocks. Exposure to high levels of naphthalene can cause symptoms such as nausea, vomiting, diarrhea, and headaches. Long-term exposure has been linked to anemia and damage to the liver and nervous system.

In addition, naphthalene is a known environmental pollutant that can be found in air, water, and soil. It is produced by the combustion of fossil fuels and is also released from some industrial processes. Naphthalene has been shown to have toxic effects on aquatic life and may pose a risk to human health if exposure levels are high enough.

I'm sorry for any confusion, but "wrestling" is not a medical term. It is an athletic activity or sport that involves two individuals trying to physically manipulate each other into a dominant position or force their opponent to the ground. If you have any medical questions or concerns, I would be happy to try and help answer those for you.

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