Testicular Neoplasms
Dysgerminoma
A malignant ovarian neoplasm, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. It is the counterpart of the classical seminoma of the testis, to which it is both grossly and histologically identical. Dysgerminomas comprise 16% of all germ cell tumors but are rare before the age of 10, although nearly 50% occur before the age of 20. They are generally considered of low-grade malignancy but may spread if the tumor extends through its capsule and involves lymph nodes or blood vessels. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1646)
Seminoma
A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Neoplasms
Incidence and occupational pattern of leukaemias, lymphomas, and testicular tumours in western Ireland over an 11 year period. (1/2042)
STUDY OBJECTIVE: To determine incidence of the following malignancies, testicular tumours, all leukaemias and all lymphomas in the West of Ireland in an 11 year period. Secondly, to examine the relation between disease patterns and available occupational data in male subjects of working age. DESIGN: A census survey of all cases occurring in the three counties in the Western Health Board (WHB) area, Galway, Mayo and Roscommon, for the 11 year period 1980 to 1990 inclusive. Average annual age standardised incidence rates for the period were calculated using the 1986 census data. Rates for the area are compared with rates from the southern region of Ireland, which had a tumour registry. Trends over the time period are evaluated. All male subjects for whom occupational data were available were categorised using the Irish socioeconomic group classification and incidence rates by occupation were compared using the standardised incidence ratio method. In one of the counties, Galway, a detailed occupational history of selected cases and an age matched control group was also elicited through patients' general practitioners. SETTING: All available case records in the West of Ireland. RESULTS: There are no national incidence records for the period. Compared with data from the Southern Tumour Registry, the number of cases of women with myeloid leukaemias was significantly lower. Male leukaemia rates were significantly lower as a group (SIR 84 (95% CI 74, 95) but not when considered as individual categories. Regression analysis revealed an increasing trend in the number of new cases of non-Hodgkin's lymphoma among both men (r = 0.47, p = 0.02) and women (r = 0.90, p = 0.0001) and of chronic lymphocytic leukaemia in men (r = 0.77, p = 0.005) and women (r = 0.68 p = 0.02) in the WHB region over the last decade. Four hundred and fifty six male cases over the age of 15 years were identified and adequate occupational information was available for 74% of these. Standardised incidence ratios of testicular tumours 100, 938) and agriworkers other than farmers (SIR 377, 95% CI 103, 967). There were also significantly increased incidence ratios for both non-Hodgkin's lymphoma (SIR 169, 95% CI 124, 266) and three categories of leukaemias among farmers. Hodgkin's disease and acute myeloid leukaemias were significantly increased among semi-skilled people. Interview data with 90 cases and 54 controls of both sexes revealed that among farmers, cases (n = 31) were significantly less likely than controls (n = 20) to use tractor mounted spraying techniques (OR = 0.19 (95% CI 0.04, 0.80)) and less likely to wear protective masks (OR 0.22 (95% CI 0.05, 0.84)). CONCLUSIONS: Trends of increase in non-Hodgkin's lymphoma and some leukaemias are consistent with studies elsewhere. The study provides further evidence of the relation between agricultural work and certain lymphoproliferative cancers. The possible carcinogenic role of chemicals used in agricultural industries must be considered as an explanation. (+info)Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. (2/2042)
The Mdm2 protein is frequently overexpressed in human non-seminomatous germ cell tumours and transitional carcinoma of the bladder where it may contribute to tolerance of wtp53. Mdm2 forms an autoregulatory feedback loop with p53; the Mdm2 gene is responsive to transactivation by p53 and once synthesized the Mdm2 protein terminates the p53 response. We show here that the topoisomerase poison etoposide, like ultra violet irradiation, inhibits Mdm2 synthesis. Cytotoxic concentrations of etoposide (IC90 for > 3 h) result in inhibition of Mdm2 induction at both the RNA and protein level. Rapid apoptosis ensues. Global transcription is not inhibited: p21waf-1/cip1 and GADD45 expression increase in a dose dependent manner. Inhibition of Mdm2 synthesis depends on the continuous presence of etoposide, suggesting the DNA damage may prevent transcription. Downregulation of Mdm2 transcript occurs in cells expressing HPV16-E6 suggesting that inhibition of Mdm2 transcription is p53-independent. When cells are -treated with a pulse (1 h) of etoposide and reincubated in drug free medium, Mdm2 synthesis commences immediately after damage is repaired (3 h) and the p53 response is attenuated. Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment conditions. This is the first observation of inhibition of Mdm2 transcription following treatment with topoisomerase (topo II) poisons, a feature that may be useful in tumour types where p53 is tolerated by overexpression of Mdm2. (+info)Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. (3/2042)
Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to environmental carcinogens. To test the importance of nucleotide excision repair in protection against chemical carcinogenesis in internal organs, we treated XPC mutant (XPC-/-) mice with 2-acetylaminofluorene and NOH-2-acetylaminofluorene. We observed a significantly higher incidence of chemically induced liver and lung tumors in XPC-/- mice compared with normal and heterozygous littermates In addition, the progression of liver tumors in XPC-/- Trp53+/- mice is accelerated compared with XPC-/- Trp53+/+ animals. Finally, we demonstrate a higher incidence of spontaneous testicular tumors in XPC-/- TrpS3-/- double mutant mice compared with XPC+/+ Trp53-/- mice. (+info)Risk of testicular cancer in subfertile men: case-control study. (4/2042)
OBJECTIVE: To evaluate the association between subfertility in men and the subsequent risk of testicular cancer. DESIGN: Population based case-control study. SETTING: The Danish population. PARTICIPANTS: Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated. OUTCOME MEASURE: Occurrence of testicular cancer. RESULTS: A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors. CONCLUSION: These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors. (+info)Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis. (5/2042)
Testicular germ cell tumours are hypersentive to chemotherapy and cell lines derived from these tumours are chemosensitive in vitro. We have previously shown that these cell lines express undetectable levels of the suppressor of apoptosis Bcl-2 and relatively high levels of the apoptosis inducer Bax (Chresta et al., 1996). To determine whether the absence of Bcl-2 in these cell lines makes them highly susceptible to drug-induced apoptosis, Bcl-2 was expressed ectopically in the 833K testicular germ cell tumour cell line. Stable overexpressing clones were isolated and three clones were studied further. Surprisingly, Bcl-2 overexpressing cells were sensitized to chemotherapy-induced apoptosis compared to the parental and vector control cells. Analysis of potential mechanisms of sensitization revealed there was a reciprocal downregulation of the endogenously expressed Bcl-X(L) in the Bcl-2 overexpressing clones. Downregulation of Bcl-X(L) to the same extent using antisense oligonucleotides enhanced etoposide-induced apoptosis by twofold. Our results indicate that Bcl-2 and Bcl-X(L) have different abilities to protect against chemotherapy-induced apoptosis in testicular germ cell tumours. In contrast to findings in some tumour cell types, Bcl-2 did not act as a gatekeeper to prevent entry of p53 to the nucleus. (+info)Expression of relaxin-like factor is down-regulated in human testicular Leydig cell neoplasia. (6/2042)
In addition to their role in steroidogenesis in the male, testicular Leydig cells constitutively express large amounts of the peptide relaxin-like factor (RLF), also known as Ley-IL. The Leydig cell-derived RLF belongs to the insulin-like superfamily, which also includes relaxin, insulin and the insulin-like growth factors, and within the testis is a specific marker of Leydig cells. Little information is available either on the regulation of gene expression or on the function of this Leydig cell-derived peptide. In the present study we have investigated the expression pattern of human RLF in patients with rare Leydig cell hyperplasia and adenoma. The expression of both mRNA and protein appear to be decreased in hyperplastic Leydig cells, whereas in the Leydig cell adenomas studied, large central areas of the adenoma were devoid of RLF mRNA and protein. Only Leydig cells located at the periphery of the adenoma displayed expression of RLF, with full agreement between in-situ hybridization and immunohistochemistry. It thus appears that the expression of the RLF gene and its products are down-regulated in Leydig cell hyperplasia and adenoma, consistent with a concomitant dedifferentiation of these cells. (+info)Testicular cancer: an oncological success story. (7/2042)
Testicular cancer has become a model for a curable neoplasm. Our studies with cisplatin combination chemotherapy allow us to conclude that: (a) short-duration intensive induction therapy with the most active agents in optimal dosage is more important than maintenance therapy; (b) modest dose escalation increases toxicity without improving therapeutic efficacy; (c) it is possible to develop curative salvage therapy for refractory germ cell tumors; and (d) preclinical models predicting synergism, such as vinblastine + bleomycin or cisplatin + etoposide have clinical relevance. Finally, testicular cancer has also become a model for new drug development. Cisplatin was approved by the Food and Drug Administration for testis and ovarian cancer, and etoposide and ifosfamide were approved for refractory germ cell tumors. The success of these studies confirms the importance of the continued search for new investigational drugs in all solid tumors. (+info)Semen quality and reproductive hormones before orchiectomy in men with testicular cancer. (8/2042)
PURPOSE: To obtain information about preorchiectomy gonadal function in patients with testicular germ cell cancer to improve the clinical management of fertility and other andrologic aspects in these men. PATIENTS AND METHODS: In group 1, a group of 83 consecutive patients with testicular germ cell cancer (TGCC) investigated before orchiectomy, semen analysis was carried out in 63 patients and hormonal investigations, including measurement of follicle-stimulating hormone, luteinizing hormone (LH), testosterone, estradiol, sex hormone-binding globulin (SHBG), inhibin B, and human chorionic gonadotropin (hCG), in 71 patients. Hormone levels in patients with elevated hCG (n = 41) were analyzed separately. To discriminate between general cancer effects and specific effects associated with TGCC, the same analyses were carried out in a group of 45 consecutive male patients with malignant lymphoma (group 2). Group 3 comprised 141 men employed in a Danish company who served as controls in the comparison of semen parameters. As a control group in hormone investigations, 193 men were selected randomly from the Danish National Personal Register to make up group 4. RESULTS: We found significantly lower sperm concentration (median, 15 x 10(6)/mL; range, 0 to 128 x 10(6)/mL) and total sperm count (median, 29 x 10(6)/mL; range, 0 to 589 x 10(6)) in patients with testicular cancer than in patients with malignant lymphomas (sperm concentration: median, 48 x 10(6)/mL; range, 0.04 to 250 x 10(6)/mL; sperm count: median, 146 x 10(6); range, 0.05 to 418 x 10(6)) (P < .001 and P < .001) and healthy men (sperm concentration: median, 48 x 10(6)/mL; range, 0 to 402 x 10(6)/mL; sperm count: median, 162 x 10(6); range, 0 to 1253 x 10(6)) (P < .001 and P < .001). FSH levels were increased in men with testicular cancer (median, 5.7 IU/L; range, 2.0 to 27 IU/L) compared with both men with malignant lymphomas (median, 3.3 IU/L; range, 1.01 to 12.0 IU/L) and healthy controls (median, 4.1 IU/L; range, 1.04 to 21 IU/L)(P = .001 and P = .007, respectively). Surprisingly, we found significantly lower LH in the group of men with TGCC (median, 3.6 IU/L; range, 1.12 to 11.9 IU/L) than in healthy men (median, 4.7 IU/L; range, 1.3 to 11.9 IU/L) (P = .01). We could not detect any differences between men with testicular cancer and men with malignant lymphomas and healthy men with regard to serum levels of testosterone, SHBG, and estradiol. Men with testicular cancer who had increased hCG levels had significantly lower LH and significantly higher testosterone and estradiol than those without detectable hCG levels. CONCLUSION: Spermatogenesis is already impaired in men with testicular cancer before orchiectomy. Neither local suppression of spermatogenesis by tumor pressure nor a general cancer effect seems to fully explain this impairment. The most likely explanation is preexisting impairment of spermatogenesis in the contralateral testis in men with testicular cancer. The question of whether also a pre-existing Leydig cell dysfunction is present in men with testicular cancer could not be answered in this study because the tumor seems to have a direct effect on the Leydig cells. Men with testicular cancer had low LH values as compared with controls. We speculate that increased intratesticular level of hCG also in men without measurable serum hCG may play a role by exerting LH-like effects on the Leydig cells, causing increased testosterone and estrogen levels and low LH values in the blood. (+info)Testicular neoplasms are abnormal growths or tumors within the testicle, which can be benign (noncancerous) or malignant (cancerous), potentially leading to serious health consequences if not identified and treated promptly.
Testicular neoplasms are abnormal growths or tumors in the testicle that can be benign (non-cancerous) or malignant (cancerous). They are a type of genitourinary cancer, which affects the reproductive and urinary systems. Testicular neoplasms can occur in men of any age but are most commonly found in young adults between the ages of 15 and 40.
Testicular neoplasms can be classified into two main categories: germ cell tumors and non-germ cell tumors. Germ cell tumors, which arise from the cells that give rise to sperm, are further divided into seminomas and non-seminomas. Seminomas are typically slow-growing and have a good prognosis, while non-seminomas tend to grow more quickly and can spread to other parts of the body.
Non-germ cell tumors are less common than germ cell tumors and include Leydig cell tumors, Sertoli cell tumors, and lymphomas. These tumors can have a variety of clinical behaviors, ranging from benign to malignant.
Testicular neoplasms often present as a painless mass or swelling in the testicle. Other symptoms may include a feeling of heaviness or discomfort in the scrotum, a dull ache in the lower abdomen or groin, and breast enlargement (gynecomastia).
Diagnosis typically involves a physical examination, imaging studies such as ultrasound or CT scan, and blood tests to detect tumor markers. Treatment options depend on the type and stage of the neoplasm but may include surgery, radiation therapy, chemotherapy, or a combination of these modalities. Regular self-examinations of the testicles are recommended for early detection and improved outcomes.
Testicular diseases refer to a range of medical conditions that affect the testes, including inflammation, infection, tumors, trauma, and congenital abnormalities, which can impact fertility, hormone production, and overall reproductive health.
Testicular diseases refer to a range of conditions that affect the testicles, the male reproductive organs located in the scrotum. These diseases can affect either one or both testicles and may cause pain, swelling, or impact fertility. Here are some examples of testicular diseases:
1. Testicular cancer: A malignant tumor that develops in the testicle. It is a relatively rare cancer but is highly treatable if detected early.
2. Testicular torsion: A surgical emergency that occurs when the spermatic cord, which supplies blood to the testicle, becomes twisted, cutting off the blood flow.
3. Epididymitis: An infection or inflammation of the epididymis, a coiled tube that stores and carries sperm from the testicle.
4. Orchitis: An infection or inflammation of the testicle itself. It can occur on its own or as a complication of mumps.
5. Hydrocele: A fluid-filled sac that forms around the testicle, causing swelling.
6. Varicocele: Enlarged veins in the scrotum that can cause pain and affect fertility.
7. Inguinal hernia: A condition where a portion of the intestine or fat protrudes through a weakened area in the abdominal wall, often appearing as a bulge in the groin or scrotum.
8. Testicular trauma: Injury to the testicle, which can result from accidents, sports injuries, or other causes.
9. Undescended testicles: A condition where one or both testicles fail to descend from the abdomen into the scrotum before birth.
It is essential for men to perform regular self-examinations to check for any unusual lumps, swelling, or pain in the testicles and seek medical attention if they notice any changes.
Dysgerminoma is a rare type of malignant germ cell tumor that primarily develops in the ovary of young women, typically occurring in the second decade of life.
Dysgerminoma is a type of germ cell tumor that develops in the ovaries. It is a malignant (cancerous) tumor that primarily affects girls and women of reproductive age, although it can occur at any age. Dysgerminomas are composed of large, round, or polygonal cells with clear cytoplasm and distinct cell borders, arranged in nests or sheets. They may also contain lymphoid aggregates and may produce hormones such as estrogen or testosterone.
Dysgerminomas are usually unilateral (affecting one ovary), but they can be bilateral (affecting both ovaries) in about 10-15% of cases. They tend to grow and spread rapidly, so early detection and treatment are crucial for a favorable prognosis.
The standard treatment for dysgerminoma is surgical removal of the affected ovary or ovaries, followed by chemotherapy with agents such as bleomycin, etoposide, and cisplatin (BEP). With appropriate treatment, the five-year survival rate for patients with dysgerminoma is high, ranging from 80% to 95%.
Seminoma is a type of germ cell tumor that typically develops in the testicle, characterized by uniform large cells with clear cytoplasm and distinct cell borders, often containing eccentric nuclei, and it usually exhibits a slow growth pattern with a strong tendency to metastasize to retroperitoneal lymph nodes.
Seminoma is a type of germ cell tumor that develops in the testicle. It is a malignant tumor, meaning it can spread to other parts of the body if left untreated. Seminomas are typically slow-growing and tend to remain localized to the testicle for a longer period compared to other types of testicular cancer. They usually occur in men between the ages of 25 and 45 but can develop at any age.
Seminomas can be classified into two main subtypes: classical seminoma and spermatocytic seminoma. Classical seminoma is more common and typically responds well to treatment, while spermatocytic seminoma is rarer and tends to have a better prognosis with a lower risk of spreading.
Seminomas are usually treated with surgery to remove the affected testicle (orchiectomy), followed by radiation therapy or chemotherapy to kill any remaining cancer cells. The prognosis for seminoma is generally good, especially when caught and treated early. Regular self-examinations of the testicles can help detect any lumps or abnormalities that may indicate the presence of a seminoma or other type of testicular cancer.
Pancreatic neoplasms are abnormal growths of tissue in the pancreas that can be benign or malignant, often characterized by progressive and invasive growth which can interfere with normal endocrine and exocrine functions, leading to serious health consequences if not detected and treated early.
Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.
Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.
Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.
There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.
Neoplasms are abnormal growths of cells or tissues that form tumors, which can be benign (noncancerous) or malignant (cancerous), and have the potential to invade local tissues and spread to distant sites in the body.
Neoplasms are abnormal growths of cells or tissues in the body that serve no physiological function. They can be benign (non-cancerous) or malignant (cancerous). Benign neoplasms are typically slow growing and do not spread to other parts of the body, while malignant neoplasms are aggressive, invasive, and can metastasize to distant sites.
Neoplasms occur when there is a dysregulation in the normal process of cell division and differentiation, leading to uncontrolled growth and accumulation of cells. This can result from genetic mutations or other factors such as viral infections, environmental exposures, or hormonal imbalances.
Neoplasms can develop in any organ or tissue of the body and can cause various symptoms depending on their size, location, and type. Treatment options for neoplasms include surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy, among others.
Neoplasms can be classified as cystic, with mucinous and serous types representing specific subcategories of cystic neoplasms, defined by the production of mucin or watery fluid, respectively, within the cysts, which can occur in various organs such as the ovaries, pancreas, and lungs.
Neoplasms: Neoplasms refer to abnormal growths of tissue that can be benign (non-cancerous) or malignant (cancerous). They occur when the normal control mechanisms that regulate cell growth and division are disrupted, leading to uncontrolled cell proliferation.
Cystic Neoplasms: Cystic neoplasms are tumors that contain fluid-filled sacs or cysts. These tumors can be benign or malignant and can occur in various organs of the body, including the pancreas, ovary, and liver.
Mucinous Neoplasms: Mucinous neoplasms are a type of cystic neoplasm that is characterized by the production of mucin, a gel-like substance produced by certain types of cells. These tumors can occur in various organs, including the ovary, pancreas, and colon. Mucinous neoplasms can be benign or malignant, and malignant forms are often aggressive and have a poor prognosis.
Serous Neoplasms: Serous neoplasms are another type of cystic neoplasm that is characterized by the production of serous fluid, which is a thin, watery fluid. These tumors commonly occur in the ovary and can be benign or malignant. Malignant serous neoplasms are often aggressive and have a poor prognosis.
In summary, neoplasms refer to abnormal tissue growths that can be benign or malignant. Cystic neoplasms contain fluid-filled sacs and can occur in various organs of the body. Mucinous neoplasms produce a gel-like substance called mucin and can also occur in various organs, while serous neoplasms produce thin, watery fluid and commonly occur in the ovary. Both mucinous and serous neoplasms can be benign or malignant, with malignant forms often being aggressive and having a poor prognosis.
Leydig cell hypoplasia
Pathology of Testicular and Penile Neoplasms. Springer. p. 184. ISBN 978-3-319-27617-5. Nieschlag, Eberhard & Behre, Hermann ( ... This results in hypoplasia or absence of Leydig cells, testicular atrophy, and lower than normal androgen levels. In the most ... June 29, 2013), "Chapter 8: Disorders at the Testicular Level", Andrology: Male Reproductive Health and Dysfunction, Springer ...
Plicamycin
Brown JH, Kennedy BJ (January 1965). "Mithramycin in the Treatment of Disseminated Testicular Neoplasms". The New England ... Plicamycin has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of ... Kennedy BJ, Torkelson JL (May 1995). "Long-term follow-up of stage III testicular carcinoma treated with mithramycin ( ...
Maurice Chevassu
Here he explains two dominant types of testicular neoplasms. In regards to surgery for testicular cancer, he doubted the ... a pioneer of the study and therapy of testicular neoplasms". J BUON. 8 (2): 185-90. PMID 17472251. New Orleans medical and ... a pioneer of the study and therapy of testicular neoplasms". J BUON. 8 (2): 185-90. PMID 17472251. Biographies - BIU Santé, ... was a French surgeon and urologist known for his work with testicular cancer. In 1906 he received his doctorate, obtaining his ...
Testicular sarcoidosis
Geller RA, Kuremsky DA, Copeland JS, Stept R (1977). "Sarcoidosis and testicular neoplasm: an unusual association". J Urol. 118 ... However, testicular tumours are much more common in white men, less than 3.5% of all testicular tumours being found in black ... Testicular sarcoidosis can present as a diffuse painless scrotal mass or can mimic acute epididymo-orchitis. Usually it appears ... The peak incidence of sarcoidosis and testicular neoplasia coincide at 20-40 years and this is why most patients end up having ...
Dactinomycin
This includes Wilms tumor, rhabdomyosarcoma, Ewing's sarcoma, trophoblastic neoplasm, testicular cancer, and certain types of ...
List of MeSH codes (C19)
... testicular neoplasms MeSH C19.391.829.782.500 - sertoli-leydig cell tumor MeSH C19.642.355.239 - hyperparathyroidism, primary ... MeSH C19.053.098.265 - adrenal cortex neoplasms MeSH C19.053.098.265.500 - adrenocortical adenoma MeSH C19.053.098.265.750 - ... ovarian neoplasms MeSH C19.391.630.705.265 - brenner tumor MeSH C19.391.630.705.331 - carcinoma, endometrioid MeSH C19.391. ... adrenal cortex neoplasms MeSH C19.344.078.265.500 - adrenocortical adenoma MeSH C19.344.078.265.750 - adrenocortical carcinoma ...
Henry Harrington Janeway
"Testicular Cancer: A Model for a Curable Neoplasm" 2010 Charles M. Balch, M.D., Johns Hopkins Medical Institute - "Melanoma as ... "What the Study of Leukemia has Taught Us about the Common Neoplasms" 1995 Lester J. Peters, M.D., East Melbourne, Australia - " ...
Hematospermia
Additionally, testicular, prostate, and epididymal inflammation in general may present with haematospermia as feature. Some ... neoplasms of the genitourinary system may present with haematospermia. Malignant causes of haematospermia include; prostate ... cancer, testicular or epididymal tumours, seminal vesicle carcinoma (rarely), and urethral tumour. Lymphomas and leukaemias may ...
Gynecomastia
... evaluation of testicular development and an assessment for masses that raise suspicion for testicular cancer, and proper ... A possible cause may be a neoplasm that originates from estrogen-secreting cells. Tumors that produce hCG stimulate production ... Testicular tumors such as Leydig cell tumors, Sertoli cell tumors (such as in Peutz-Jeghers syndrome) and hCG-secreting ... Markers of testicular, adrenal, or other tumors such as urinary 17-ketosteroid or serum dehydroepiandrosterone may also be ...
Adenomatoid tumor
On the other hand, adenomatoid tumors are the most common tumors of testicular adnexa. Although they are more common to be ... Benign neoplasms, Connective and soft tissue neoplasms). ... It is the most common extratesticular neoplasm after lipoma, ... An example of this is when adenomatoid tumors grow too close to testicular adnexal structures. Tumors of this kind are usually ... "Testicular Adenomatoid Tumor Pathology: Definition, Epidemiology, Etiology". 2019-11-26. {{cite journal}}: Cite journal ...
GPER
Carreau S, Bois C, Zanatta L, Silva FR, Bouraima-Lelong H, Delalande C (2011). "Estrogen signaling in testicular cells". Life ... Immunohistochemical and transcriptomic analyses of neoplasms derived from a variety of tissues including but not limited to: ... breast, endometrial, ovarian, and testicular directly link GPER to advanced disease and prometastatic growth and survival. ...
Seminoma
... or there may be testicular atrophy. Testicular pain is reported in up to one fifth of cases. Low back pain may occur after ... It is a malignant neoplasm and is one of the most treatable and curable cancers, with a survival rate above 95% if discovered ... Testicular seminoma originates in the germinal epithelium of the seminiferous tubules. About half of germ cell tumors of the ... "NCCN Testicular Cancer Guidelines". NCCN Clinical Practice Guidelines in Oncology. Nichols CR, Roth B, Albers P, Einhorn LH, ...
Rete tubular ectasia
Unlike cystic neoplasms, they don't present specific tumor markers. Another distinguishing feature is that tubular ectasia of ... the testes are confined only to the mediastinum, unlike testicular cancer such as cystic teratoma of testis which spreads ...
Endodermal sinus tumor
Germ cell tumor Testicular cancer "Endodermal Sinus Tumor". Retrieved 2018-10-10. Hari, Anil; Grossfeld, Gary; Hricak, Hedvig ( ... Before modern chemotherapy, this type of neoplasm was highly lethal, but the prognosis has significantly improved since then.[ ... It is the most common testicular tumor in children under three, and is also known as infantile embryonal carcinoma. This age ... Prepubertal Testicular and Paratesticular Tumors at eMedicine (CS1 maint: multiple names: authors list, Articles with short ...
Small supernumerary marker chromosome
However, it may also be active in causing birth defects and neoplasms (e.g. tumors and cancers). The sSMC's small size makes it ... also termed dysgerminoma to indicate that this tumor has the pathology of the testicular tumor, seminoma, but develops in ... Surgical removal of the gonads has been recommended to remove the threat of developing these sSMC-associated neoplasms. Tuner ... and malignant neoplasms which may be diagnosed at any age.[citation needed] The Cat eye syndrome (CES), also termed the Schmid- ...
Turner syndrome
Surgical removal of the gonads has been recommended to remove the threat of developing these sSMC-associated neoplasms. Tuner ... also termed dysgerminomas to indicate that this tumor has the pathology of the testicular tumor, seminoma, but develops in ... or non-specific in situ gonadal neoplasm (1 case). Turner syndrome girls with this sSMC otherwise have typical features of the ... syndrome individuals with this SRY gene-containing sSMC have a very real increased risk of developing gonadal tissue neoplasms ...
Primrose syndrome
The patient also developed testicular cancer, but it is unknown whether or not it is related to the syndrome. The patient ... described an adult male intellectually disabled patient who had calcified pinnae and a neoplasm of the palate. The patient also ... Mathijssen, Inge B.; Hasselt-van der Velde, Jos; Hennekam, Raoul C.M. (March 2006). "Testicular cancer in a patient with ... a neoplasm on the mouth's hard palate), muscle atrophy, and distorted facial features. Other symptoms usually occur, different ...
H19 (gene)
In contrast to most other cancers, adrenocortical neoplasms appear to have decreased expression of H19. To determine a possible ... testicular germ cell cancer, esophageal cancer and lung cancer. Cellular DNA integrity is often compromised in cancer. Genome ... adrenocortical neoplasms, choriocarcinomas, hepatocellular carcinomas, bladder cancers, ovarian serous epithelial cancers, head ...
Oligospermia
Post-testicular factors decrease male fertility due to conditions that affect the male genital system after testicular sperm ... Age Genetic defects on the Y chromosome Y chromosome microdeletions Abnormal set of chromosomes Klinefelter syndrome Neoplasm, ... Testicular factors refer to conditions where the testes produces semen of poor quality despite adequate hormonal support and ... Articles with short description, Short description is different from Wikidata, Testicular infertility factors). ...
Adjuvant therapy
"Testicular Cancer Survival Rates". American Cancer Society. Travis, LB (4 August 2010). "Testicular cancer survivorship: ... Depending on what form of treatment is used, adjuvant therapy can have side effects, like all therapy for neoplasms. ... In testicular cancer, adjuvant either radiotherapy or chemotherapy may be used following orchidectomy. Previously, mainly ... Though the 5-year survival rates for stage I testicular cancers is approximately 99%, there still exists controversy over ...
IGF2BP2
2005). "Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer". Reproduction. 130 (2): 203-12. doi: ... 2007). "Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms". Haematologica. 92 (2): 176- ...
Spermatocele
However, if a "must not miss" diagnoses related to testicular masses such as testicular torsion, epididymitis, acute orchitis, ... and neoplasm. The primary care physician may diagnose and manage benign causes of scrotal masses such as hydrocele, varicocele ... It is best to perform a testicular self-exam after a warm shower to help the scrotum relax. To properly exam the scrotum, look ... Performing a monthly testicular self-exam can improve the person's chances of identifying spermatoceles or any abnormalities ...
Male infertility
Pre-testicular conditions can often be addressed by medical means or interventions. Testicular-based male infertility tends to ... Age group 12-49 (Paternal age effect) Aneuploidy, an abnormal number of chromosomes Centriole Neoplasm, e.g. seminoma ... A decreased testicular vascularization is characteristic of testicular torsion, whereas hyperemia is often observed in ... Post-testicular factors decrease male fertility due to conditions that affect the male genital system after testicular sperm ...
Papillary renal cell carcinoma
Table 3 from: Weiss, Lawrence M.; Gelb, Arnold B.; Jeffrey Medeiros, L. (1995). "Adult Renal Epithelial Neoplasms". American ... and Testicular Tumours". European Urology. 70 (1): 93-105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559. ... of all kidney neoplasms. Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 ( ... "Enhancement characteristics of papillary renal neoplasms revealed on triphasic helical CT of the kidneys". AJR. American ...
Pineal gland
As it is quite cellular (in relation to the cortex and white matter), it may be mistaken for a neoplasm. The human pineal gland ... Histologically they are similar to testicular seminomas and ovarian dysgerminomas. A pineal tumor can compress the superior ... These neoplasms are divided into three categories: pineoblastomas, pineocytomas, and mixed tumors, based on their level of ...
Sertoli-Leydig cell tumour
The tumour occurs in early adulthood (not seen in newborn), is rare, comprising less than 1% of testicular tumours. While the ... A rare ovarian neoplasm. Case report and review of literature". Gynecological Endocrinology. 24 (4): 230-4. doi:10.1080/ ... is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group of ovarian and testicular ... and in the case of intermediate and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous ...
Spermatocytic tumor
... is a rare tumour, making up only one to two percent of all testicular germ cell tumours. Men presenting ... Spermatocytic tumor, previously called spermatocytic seminoma, is a neoplasm of the testis (i.e. a tumour of the testis), and ... Immunostaining for most of the usual testicular germ cell tumour markers is negative (i.e. placental alkaline phosphatase (PLAP ... Most present with slow, painless testicular enlargement, which may involve both testes. Spermatocytic tumors are diagnosed ...
Mediastinal germ cell tumor
C R Nichols; N A Heerema; C Palmer (1987). "Klinefelter's syndrome associated with mediastinal germ cell neoplasms". Journal of ... The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. ... of all germ cell neoplasms. Syndromes associated with mediastinal germ cell tumors include Hematologic Neoplasia and ...
Tumors of the hematopoietic and lymphoid tissues
CEBPA mutation Myeloid neoplasms with germline DDX41 mutation Myeloid neoplasms with germline RUNX1 mutation Myeloid neoplasms ... nodal marginal zone lymphoma Follicular lymphoma In situ follicular neoplasia Duodenal-type follicular lymphoma Testicular ... neoplasms with PDGFRA rearrangement Myeloid/lymphoid neoplasms with PDGFRB rearrangement Myeloid/lymphoid neoplasms with FGFR1 ... NOS Lymphoid neoplasms Precursor lymphoid neoplasms B-lymphoblastic leukaemia/lymphoma, NOS B-lymphoblastic leukaemia/lymphoma ...
Germ cell tumor
... (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or benign. Germ cells normally ... Gill MS, Shah SH, Soomro IN, Kayani N, Hasan SH (2000). "Morphological pattern of testicular tumors". J Pak Med Assoc. 50 (4): ... Verville KM (2009). Testicular Cancer. Infobase Publishing. p. 76. ISBN 978-1-60413-166-6. humpath #2658 (Pathology images) ... In males, GCTs of the testis occur typically after puberty and are malignant (testicular cancer). In neonates, infants, and ...
Splenogonadal fusion
A few cases of testicular neoplasm have been reported in association with splenogonadal fusion. The reported cases have ... but literature has highlighted infrequent cases of testicular neoplasms and splenogonadal fusion. These cases were found in ... Lopes RI, de Medeiros MT, Arap MA, Cocuzza M, Srougi M, Hallak J (Jan-Mar 2012). "Splenogonadal fusion and testicular cancer: ... Akbar, SA; Sayyed, TA; Jafri, SZ; Hasteh, F; Neill, JS (November 2003). "Multimodality imaging of paratesticular neoplasms and ...
Transillumination
... similar to what may be encountered with testicular neoplasms. A convenient method to differentiate the conditions is to ... "Testicular Masses." Am Fam Physician. 1998 Feb 15;57(4): 685-692. (Articles needing additional references from December 2021, ...
List of MeSH codes (C12)
MeSH C12.294.260.500 - penile neoplasms MeSH C12.294.260.750 - prostatic neoplasms MeSH C12.294.260.937 - testicular neoplasms ... penile neoplasms MeSH C12.740.800.410.650 - prostatic neoplasms MeSH C12.740.800.410.875 - testicular neoplasms MeSH C12.740. ... 800.820 - urologic neoplasms MeSH C12.740.800.820.125 - bladder neoplasms MeSH C12.740.800.820.750 - kidney neoplasms MeSH ... ureteral neoplasms MeSH C12.740.800.820.937 - urethral neoplasms MeSH C12.777.103.124 - bladder calculi MeSH C12.777.103.132 - ...
Testicle
To improve the chances of catching cases of testicular cancer, other neoplasms, or other health issues early, regular ... Testicular enlargement is an unspecific sign of various testicular diseases, and can be defined as a testicular size of more ... Testicular size as a proportion of body weight varies widely. In the mammalian kingdom, there is a tendency for testicular size ... Testicular prostheses are available to mimic the appearance and feel of one or both testicles, when absent as from injury or as ...
Urogenital neoplasm
Testicular cancer) Cancer of the urinary organs (Bladder cancer, Renal cell carcinoma) Kurman RJ (2013). Blaustein's Pathology ... A urogenital neoplasm is a tumor of the urogenital system. Types include: Cancer of the female genital organs: (Cervical cancer ... Neoplasm stubs, Disease stubs, Genitourinary system stubs). ...
Primordial germ cell migration
Tumour formation (neoplasm) from foetal gonocytes suggests that they are incapable of maintaining proliferative arrest and ... Mutations in Pten, CyclinD1, Dmrt1 and Dnd1 oncogenes in mice resulted in testicular teratomas, and variants are related with ...
Laboratory rat
All but one of the testicular tumors occurred in the rats from a single supplier. The researchers found that the incidence of ... Mac Kenzie, William; Garner, F. (1973). "Comparison of Neoplasms in Six Sources of Rats". JNCI: Journal of the National Cancer ... The Lewis rat suffers from several spontaneous pathologies: first, they can suffer from high incidences of neoplasms, with the ... A 1972 study compared neoplasms in Sprague Dawleys from six different commercial suppliers and found highly significant ...
Researchers interested in Testicular Neoplasms | Yale School of Medicine
![PGS Catalog - testicular neoplasm [EFO:0004281] (Polygenic Trait)](data:image/png;base64,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)
PGS Catalog - testicular neoplasm [EFO:0004281] (Polygenic Trait)
Germ cell tumors ( GERMINOMA) of the testis constitute 95% of all testicular neoplasms. ... Reported Trait: Malignant neoplasm of testis. -. -. Partial Correlation (partial-r): 0.0053 [-0.0286, 0.0392]. sex, age, birth ... Reported Trait: Malignant neoplasm of testis. -. -. Partial Correlation (partial-r): -0.0156 [-0.0636, 0.0325]. sex, age, birth ... Reported Trait: Malignant neoplasm of testis. -. -. Partial Correlation (partial-r): 0.0324 [0.0114, 0.0533]. sex, age, birth ...
Testicular cancer: MedlinePlus Medical Encyclopedia
Testicular cancer is cancer that starts in the testicles. The testicles are the male reproductive glands located in the scrotum ... Testicular cancer is cancer that starts in the testicles. The testicles are the male reproductive glands located in the scrotum ... Cancer - testes; Germ cell tumor; Seminoma testicular cancer; Nonseminoma testicular cancer; Testicular neoplasm ... Testicular cancer treatment (PDQ) - health professional version. www.cancer.gov/types/testicular/hp/testicular-treatment-pdq# ...
Leydig cell hypoplasia - Wikipedia
Pathology of Testicular and Penile Neoplasms. Springer. p. 184. ISBN 978-3-319-27617-5. Nieschlag, Eberhard & Behre, Hermann ( ... This results in hypoplasia or absence of Leydig cells, testicular atrophy, and lower than normal androgen levels. In the most ... June 29, 2013), "Chapter 8: Disorders at the Testicular Level", Andrology: Male Reproductive Health and Dysfunction, Springer ...
Testicular Cancer | Testicular Cancer Symptoms | MedlinePlus
Testicular cancer mainly affects young men between the ages of 20 and 39. Symptoms include pain, swelling, or lumps in your ... ClinicalTrials.gov: Testicular Neoplasms (National Institutes of Health) Journal Articles References and abstracts from MEDLINE ... Testicular Cancer Screening (National Cancer Institute) Also in Spanish * Tests for Testicular Cancer (American Cancer Society) ... Key Statistics for Testicular Cancer (American Cancer Society) Also in Spanish * Whats New in Testicular Cancer Research? ( ...
Prepubertal Testicular and Paratesticular Tumors: Practice Essentials, Pathophysiology, Etiology
Testicular tumors account for 1-2% of all pediatric tumors, with an incidence of 0.05-2 per 100,000 children. ... Testicular and paratesticular neoplasms in prepubertal males. J Urol. 2006 Sep. 176 (3):875-81. [QxMD MEDLINE Link]. ... Pediatric prepubertal testicular tumors are dramatically different from adult neoplasms. Germ-cell tumors account for only 60- ... For patient education resources, see the Mens Health Center and the Cancer Center, as well as Testicular Cancer and Testicular ...
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, ... Neoplasms, Germ Cell and Embryonal / genetics* * Polymorphism, Single Nucleotide * RNA-Binding Proteins / genetics* ... Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. So far, ... Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14 Nat Genet. 2013 ...
Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT)
span,,b,Background:,/b, Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. ... Neoplasms, Germ Cell and Embryonal / epidemiology* * Risk Factors * Tandem Mass Spectrometry * Testicular Neoplasms / ... Background: Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. In contrast ... Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT) Cancer Epidemiol Biomarkers Prev. 2018 Apr;27(4 ...
Pathology Case Reports, Elsevier E-Book on VitalSource, 1st Edition - 9780323754927
Testicular cancer Information | Mount Sinai - New York
... recovery and follow-up care for Testicular cancer. ... Learn about Testicular cancer, find a doctor, complications, ... Cancer - testes; Germ cell tumor; Seminoma testicular cancer; Nonseminoma testicular cancer; Testicular neoplasm ... Testicular cancer treatment (PDQ) - health professional version. www.cancer.gov/types/testicular/hp/testicular-treatment-pdq# ... Performing a testicular self-examination (TSE) each month may help detect testicular cancer at an early stage, before it ...
Jonatan Axelsson - Fingerprint
- Lund University
Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an...
Vinblastine - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Kidney Neoplasms. *Lung Neoplasms. *Mycosis Fungoides. *Purpura, Thrombocytopenic, Idiopathic. *Sarcoma, Kaposi. *Testicular ... For testicular germ cell carcinomas, the starting dose of vinblastine was reported as 3 mg/m2 in a combination regimen. Dose ... testicular cancer, and a certain type of uterine cancer. Vinblastine belongs to a group of drugs called vinca alkaloids which ...
Book - Essentials of Pediatric Surgery
| Bentham Science
These include undescended testis, testicular neoplasm, ovarian cyst, and ovarian neoplasm, and ambiguous genitalia. Undescended ... Testicular neoplasm has different types; the most common type is yolk sac tumor. Ovarian cysts are quite common in childhood ... Infection, Trauma, neoplasm, or congenital origin are some of the cause of lesions. The hemangioma, Lymphangiomas and cystic ... In children, the malignant neoplasms may include neuroblastoma, lymphoma, and rhabdomyosarcoma. The abnormal growth of cells ...
Testicular Masses | AAFP
... including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer. Referral to a urologist ... Family physicians must keep in mind the emergency or must not miss diagnoses associated with testicular masses, ... Family physicians often must evaluate patients with testicular pain or masses. The incidental finding of a scrotal mass may ... since a reactive hydrocele may occur with a testicular neoplasm. Adults do not require therapy for hydrocele unless ...
Testicular teratoma in an infant | Pediatric Oncall Journal
Testicular Teratoma in an Infant Read More about Scrotal Swelling, Benign Testicular Tumour on Pediatric Oncall ... Testicular neoplasms in infants and children are rare, representing 1% of all paediatric solid tumors and 3% of testicular ... Testicular and paratesticular neoplasms in prepubertal males. J Urol 2006; 176: 875-881. [CrossRef] ... 4) Pure testicular teratomas in prepubertal boys have not been reported to metastasize, whereas testicular teratomas in adults ...
Syndromes Associated with Mediastinal Nonseminomatour Germ Cell Tumors | health.am
Testicular germ cell neoplasms have rarely been reported in association with Klinefelter syndrome; therefore, the association ... All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence ... Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows ... Hematologic neoplasms have included acute myeloid leukemia, acute nonlymphocytic leukemia, acute lymphocytic leukemia, ...
Simultaneously Detected Bilateral Testicular Cancer of Different Histopathological Origin
... presented with bilateral testicular swelling. Investigations included laboratory workup, ultrasound of both testes, as well as ... Bilateral detected testicular neoplasm is a rare situation, and to the authors knowledge, at present there is no case reported ... Synchronous bilateral testicular neoplasm is a rare situation, involving about 2% of patients.[3,4] ... the mortality of testicular cancer generally decreased in the last decades. However, metastatic bilateral testicular cancer of ...
Richard Barth's Profile | Stanford Profiles
Further, the authors discuss testicular neoplasms in the context of testicular microlithiasis. ... Testicular blood flow was judged symmetric in all 34 (100%) patients with power Doppler US and in 31 (91%) patients with color ... With power Doppler US, testicular blood flow in healthy children is symmetric, underscoring that the asymptomatic testis can be ... The authors present an update on ultrasound diagnosis and outcomes in testicular torsion and differentiation from other acute ...
Christina Bøg Pedersen - Research output
- University of Southern Denmark
Cancer Death Risk Related to Radiation Exposure from Computed Tomography Scanning Among Testicular Cancer Patients | Anticancer...
Second malignant neoplasms in testicular cancer survivors. J Natl Compr Canc Netw 10(4): 545-556, 2012. ... Testicular cancer patients fall into the AYA group.. In testicular cancer the recommended imaging frequency is high and it ... Testicular cancer patients become exposed to substantial radiation doses form CT examinations during follow-up (9). The risk of ... www.cancer.gov/types/testicular/hp/testicular-treatment-pdq#section/117 ...
5-year-old male intact German Shepherd Dog - American College of Veterinary Radiology
Given history, a Sertoli cell tumor is the primary differential diagnosis, with other testicular neoplasms considered less ... sign has been reported in a dog with torsion of a cryptorchid testicular neoplasm on computed tomography previously. This case ... Testicular torsion is generally associated with neoplasia in dogs, with increased risk with large tumors. Sonographic features ... In dogs diagnosed with testicular neoplasia, anywhere from 4-20% of cases will have multiple primary tumors, as seen in this ...
Testicular Biopsy for Fertility Preservation in Prepubertal Boys with Cancer: Identifying Preferences for Procedure and...
testicular neoplasms Identity. Digital Object Identifier (DOI) * 10.1016/j.juro.2016.02.2967 ... Testicular Biopsy for Fertility Preservation in Prepubertal Boys with Cancer: Identifying Preferences for Procedure and ... We measured and compared parent, male cancer survivor and provider willingness to accept the risk of testicular biopsy among ... The threshold technique was used to measure subject relative willingness to accept risk of testicular biopsy under 4 different ...
Seminoma | Harvard Catalyst Profiles | Harvard Catalyst
Inflammatory and Nested Testicular Sex Cord Tumor: A Novel Neoplasm With Aggressive Clinical Behavior and Frequent EWSR1::ATF1 ... A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually ... Biomarkers in Testicular Cancer: Classic Tumor Markers and Beyond. Urol Clin North Am. 2023 Feb; 50(1):133-143. ... Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative ...
Giant Sertoli cell nodule of the testis: distinction from other Sertoli cell lesions | Journal of Clinical Pathology
Fetal Age & Pregnancy Test In Charlotte | Any Lab Test Now
TumorsTestisDecreased spermatogenesisSeminomaMetastasisTumorTeratomaBenignChemotherapyUltrasonographyBiopsyIncluding testicular torsionPediatricTumoursAtrophyBilateral testicularOvarianTorsionCancersScrotalDiagnosisRisk FactorsCancer SurvivorsIncidencePatientsAbnormalMortalityHistologyMiddle-agedChronicMalesLeydigLymphaticHistologically
Tumors30
- Germ cell tumors ( GERMINOMA) of the testis constitute 95% of all testicular neoplasms. (pgscatalog.org)
- Testicular tumors account for 1-2% of all pediatric tumors, with an incidence of 0.05-2 per 100,000 children. (medscape.com)
- Pediatric prepubertal testicular tumors are dramatically different from adult neoplasms. (medscape.com)
- Germ-cell tumors account for only 60-77% of testicular tumors in children but account for 95% of testicular tumors in adults. (medscape.com)
- The 2016 update of the World Health Organization (WHO) classification of testicular germ-cell tumors divided them into two broad categories on the basis of whether they are derived from a precursor lesion: germ-cell neoplasia in situ (GCNIS). (medscape.com)
- Some series have suggested that teratomas, which most believe are vastly underreported because of their benign nature, may account for almost 50% of prepubertal testicular tumors. (medscape.com)
- [ 9 ] A descriptive analysis of prepubertal testicular germ-cell tumors from a large Chinese center cited frequencies of 50.9% for teratomas, 29.2% for yolk-sac tumors, 19.3% for epidermoid cysts, and 0.6% for mixed germ-cell tumors. (medscape.com)
- Prepubertal teratomas account for fewer than 30% of testicular germ-cell tumors in children and are uniformly benign. (medscape.com)
- Inguino-scrotal swellings in children are fairly common with many causes varying from hernia, hydrocele to testicular tumors. (pediatriconcall.com)
- Testicular neoplasms in infants and children are rare, representing 1% of all paediatric solid tumors and 3% of testicular tumors. (pediatriconcall.com)
- 2) Childhood testicular tumors are more likely to be benign and have lower incidence of metastasis (2) and are the second most common testicular tumour in children after yolk sac tumor. (pediatriconcall.com)
- 5) Inguinal orchiectomy has traditionally been the gold standard of treatment for testicular tumors in childhood. (pediatriconcall.com)
- Many patients with extragonadal germ cell tumors have histories of infertility, and testicular biopsy in these patients shows various abnormalities, including decreased spermatogenesis, peritubular fibrosis, and interstitial edema. (health.am)
- In addition, patients who are successfully treated for extragonadal germ cell tumors have a markedly increased risk of developing a subsequent testicular germ cell tumor. (health.am)
- Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
- All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
- However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)
- In dogs diagnosed with testicular neoplasia, anywhere from 4-20% of cases will have multiple primary tumors, as seen in this case. (acvr.org)
- Testicular torsion is generally associated with neoplasia in dogs, with increased risk with large tumors. (acvr.org)
- Testicular germ cell tumors and, in particular, seminomas are exquisitely radiation and chemotherapy-sensitive and most presentations are highly curable. (icr.ac.uk)
- Continuous administration of estrogens for 7-9 months, both steroidal and nonsteroidal, to male BALB/c mice, leads to the formation of testicular Leydig cell tumors. (llu.edu)
- A novel mouse model of testicular granulosa cell tumors. (tamu.edu)
- SUMMARY ANSWER: Overactivation of TGFB signaling results in the development of testicular tumors resembling granulosa cell tumors (GrCTs). (tamu.edu)
- We further investigated the molecular features of testicular tumors and determined the expression of beta-catenin (CTNNB1) known to be involved in testicular GrCT development. (tamu.edu)
- Pediatric testicular tumors: contemporary incidence and efficacy of testicular preserving surgery. (medscape.com)
- Racial differences among boys with testicular germ cell tumors in the United States. (medscape.com)
- Risk stratification of pubertal children and postpubertal adolescents with clinical stage I testicular nonseminomatous germ cell tumors. (medscape.com)
- Prepubertal testicular tumors: a 20-year experience with 40 cases. (medscape.com)
- Technological advances in imaging as well as increased knowledge of tumor-specific biology have promoted the role of organ-sparing approaches to pediatric renal and testicular tumors. (nebraska.edu)
- Patients with breast, cervical, ovarian and testicular cancer, lymphoma, and brain tumors were identified in national quality registries. (lu.se)
Testis10
- Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. (ku.dk)
- The patient should perform the Valsalva maneuver while standing so he can be evaluated for a mass of dilated testicular veins in the spermatic cord forming a varicocele above and behind the testis. (aafp.org)
- In this disorder, incomplete attachment of the gubernaculum and testicular tunics to dartos fascia causes the cord to twist above the level of the testis and tunica vaginalis. (aafp.org)
- According to recent reports, testis preserving surgery has become a serious option in the treatment of benign testicular tumours. (pediatriconcall.com)
- 6) Testis preserving surgery should be reserved for testicular tumor proved to be benign by normal level of serum alpha-fetoprotein and frozen biopsy report. (pediatriconcall.com)
- Experience with testis-sparing surgery for testicular teratoma. (pediatriconcall.com)
- Testicular biopsy is indicated in azoospermic men with a normal-sized testis and normal findings on hormonal studies to evaluate for ductal obstruction, to further evaluate idiopathic infertility, and to retrieve sperm. (medscape.com)
- A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. (harvard.edu)
- The effect of constitutively active TGFBR1 on testis development and the timeline of testicular tumor formation were examined. (tamu.edu)
- Neoplasms of the testis. (medscape.com)
Decreased spermatogenesis1
- Epidemiological risk factors for TC are components of the testicular dysgenesis syndrome, which encompasses cryptorchidism, hypospadias, decreased spermatogenesis and impaired fertility [ 11-13 ] or disorders/differences of sex development [ 14 ]. (uroweb.org)
Seminoma4
- Seminoma: This is a slow-growing form of testicular cancer found in men in their 40s and 50s. (medlineplus.gov)
- Patterns of Disease Progression and Outcome of Patients With Testicular Seminoma Who Relapse After Adjuvant or Curative Radiation Therapy. (harvard.edu)
- Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up. (icr.ac.uk)
- Testicular seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (icr.ac.uk)
Metastasis2
- 4) Pure testicular teratomas in prepubertal boys have not been reported to metastasize, whereas testicular teratomas in adults are associated with clinical metastasis in 60% cases. (pediatriconcall.com)
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
Tumor9
- A stromal tumor is a rare type of testicular tumor. (medlineplus.gov)
- Testicular germ cell tumor (TGCT) is the most common cancer in young men and is notable for its high familial risks. (nih.gov)
- Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. (nih.gov)
- 1) The reported incidence of testicular tumor in children ranges from 0.5-2.0 cases per 100,000 boys as against 5.4 cases per 100,000 men. (pediatriconcall.com)
- Prepubertal testicular tumor: Actual prevalence rate of histological types. (pediatriconcall.com)
- Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
- More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)
- Given history, a Sertoli cell tumor is the primary differential diagnosis, with other testicular neoplasms considered less likely. (acvr.org)
- Biomarkers in Testicular Cancer: Classic Tumor Markers and Beyond. (harvard.edu)
Teratoma2
- Thus, testicular teratoma should be considered in any child with painless inguino-scrotal swelling. (pediatriconcall.com)
- Carver BS, Ahmadie HA, Sheinfeld J. Adult and Paediatric testicular teratoma. (pediatriconcall.com)
Benign1
- The hemangioma, Lymphangiomas and cystic hygroma in children, are the widespread benign neoplasm. (benthamscience.com)
Chemotherapy2
- Significant differences in survival were revealed when comparison was made with developing countries, for people with cancers that can be successfully treated by chemotherapy (malignant lymphomas, leukaemia, testicular tumours) and modest differences for neoplasms that can be cured by early detection and surgical intervention. (who.int)
- More than half of patients with testicular cancer treated with first-line cisplatin-based chemotherapy in a recent study developed hearing loss (HL) or tinnitus. (medscape.com)
Ultrasonography1
- Tallen G, Hernáiz Driever P, Degenhardt P, Henze G, Riebel T. High reliability of scrotal ultrasonography in the management of childhood primary testicular neoplasms. (medscape.com)
Biopsy4
- We measured and compared parent, male cancer survivor and provider willingness to accept the risk of testicular biopsy among prepubertal boys with cancer, and identified reactions to disclosure practices. (mcmaster.ca)
- The threshold technique was used to measure subject relative willingness to accept risk of testicular biopsy under 4 different aspects of care, ie chance of infertility, complications from biopsy, development of technology to use tissue and tissue storage cost. (mcmaster.ca)
- RESULTS: A total of 52 survivors (67%), 22 providers (73%) and 110 parents (72%) selected to have testicular biopsy (vs no biopsy). (mcmaster.ca)
- CONCLUSIONS: Parents, survivors and providers were willing to accept risk of prepubertal testicular biopsy. (mcmaster.ca)
Including testicular torsion1
- Family physicians must keep in mind the emergency or "must not miss" diagnoses associated with testicular masses, including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer. (aafp.org)
Pediatric1
- In human literature, detection of the 'whirl' sign is a reliable method for diagnosing testicular torsion in pediatric and adult males, and the 'whirl' sign has been reported in a dog with torsion of a cryptorchid testicular neoplasm on computed tomography previously. (acvr.org)
Tumours1
- Testicular cancer represents 1% of adult neoplasms and 5% of urological tumours, with three to ten new cases per 100,000 males/per year in Western societies [ 6 ]. (uroweb.org)
Atrophy3
- This results in hypoplasia or absence of Leydig cells, testicular atrophy, and lower than normal androgen levels. (wikipedia.org)
- Chronic testicular lesions, including orchitis and testicular torsion, can cause unilateral or bilateral testicular atrophy. (aafp.org)
- Testicular and ovarian atrophy was also seen in mice. (cdc.gov)
Bilateral testicular4
- A 36-year-old male with a history of cryptorchidism of the right side, treated with orchidopexy at the age of 4, presented with bilateral testicular swelling. (cancernetwork.com)
- However, metastatic bilateral testicular cancer of different histology is a challenging situation for the urologist, which warrants further discussion. (cancernetwork.com)
- Synchronous bilateral testicular neoplasm is a rare situation, involving about 2% of patients. (cancernetwork.com)
- A 36-year-old male presented to his primary care practitioner with bilateral testicular swelling. (cancernetwork.com)
Ovarian1
- Therapeutic progress in ovarian cancer, testicular cancer and the sarcomas / edited by A. T. van Oosterom, F. M. Muggia, F. J. Cleton. (who.int)
Torsion6
- In cases of testicular torsion, an anatomic deformity allows the spermatic cord to twist, resulting in occlusion of testicular blood flow. (aafp.org)
- Intravaginal testicular torsion occurs most often in young men but can also affect middle-aged men. (aafp.org)
- Patients with testicular torsion often present with sudden, severe, unilateral scrotal pain that is often associated with nausea and vomiting. (aafp.org)
- Exploratory laparotomy was performed and confirmed a cryptorchid testicular mass with marked torsion. (acvr.org)
- Less common but important clinical manifestations include bone marrow suppression and testicular torsion. (acvr.org)
- In this case, a 'whirl' sign was appreciated, further supporting a diagnosis of testicular torsion. (acvr.org)
Cancers3
- Testicular cancer is one of the most treatable and curable cancers. (medlineplus.gov)
- Vinblastine is a prescription medication used to treat a variety of cancers including Hodgkin's disease, lymphoma, breast cancer, testicular cancer, and a certain type of uterine cancer. (rxwiki.com)
- Testicular cancer is one of the leading cancers affecting younger men in Western countries. (cancernetwork.com)
Scrotal1
- Patients with a testicular mass may present with a painless lump or scrotal pain, which can range from severe pain to a dull ache that worsens with exercise. (aafp.org)
Diagnosis2
- A cohort of 115 testicular cancer patients scanned between 1995-2011 was studied to define the average effective dose (mean, SD) from abdominal and whole body CTs done for the diagnosis and/or follow up of testicular cancer using different scanners in the observation period and summing them over all patients and age groups. (iiarjournals.org)
- Testicular cancer (TC) is one example, with a median diagnosis age of only 30 years, and with TC the leading malignancy among men age 20-39 years. (medscape.com)
Risk Factors1
- Additional risk factors include a family history of TC among first-degree relatives and the presence of a contralateral testicular tumour or GCNIS [ 15-22 ]. (uroweb.org)
Cancer Survivors1
- For their study, Sanchez and colleagues enrolled cisplatin-treated testicular cancer survivors at eight cancer centers between 2012 and 2018. (medscape.com)
Incidence2
- 1] The estimated incidence in the United States for 2009 is about 8,400 cases, and the testicular cancer-related death rate is estimated to be 380. (cancernetwork.com)
- The data presented in this edition of Cancer Incidence in Five The CI5 data include all invasive malignant neoplasms and Continents (CI5) are mainly organised according to anatomical some non-invasive malignant neoplasms For most morphology site However, for some sites, the histological type of cancer codes, a fifth digit /1 or /2 automatically excludes the data entry. (who.int)
Patients4
- Family physicians often must evaluate patients with testicular pain or masses. (aafp.org)
- Patients and Methods: Estimate effective doses were computed from CT scans of testicular cancer patients treated and followed-up in Turku University Hospital, South Western Finland. (iiarjournals.org)
- Testicular cancer patients fall into the AYA group. (iiarjournals.org)
- We have recorded data and calculated effective and organ doses from CT scans of testicular cancer patients ( 5 ). (iiarjournals.org)
Abnormal2
- The abnormal growth of cells like primary or metastatic masses in the head and neck, thyroid and parathyroid lesions, or the traumatic injuries of the head and neck represents malignant neoplasm. (benthamscience.com)
- Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Mortality2
- Due to improved diagnostic tools as well as the establishment of various adjuvant treatment options, the mortality of testicular cancer generally decreased in the last decades. (cancernetwork.com)
- Results of epidemiological studies indicated that there was a nonstatistically significant excess mortality for lymphatic and hematopoietic neoplasms, and leukemia. (cdc.gov)
Histology1
- To the authors' knowledge, we report the first case of a patient affected by synchronous testicular cancer of different histology. (cancernetwork.com)
Middle-aged2
- Testicular cancer is the most common cancer in young and middle-aged men. (medlineplus.gov)
- Poorly differentiated carcinomas near or at midline regions of the mediastinum or retroperitoneum in young or middle-aged males should be considered germ cell neoplasms-even in the absence of a testicular mass. (msdmanuals.com)
Chronic1
- DQFHUV DVVRFLDWHG ZLWK FKURQLF LQIHFWLRQV IARC epidemiologists have estimated that in developing countries up to 20% of all human neoplasms develop in association with chronic infectious conditions. (who.int)
Males1
- Testicular and paratesticular neoplasms in prepubertal males. (pediatriconcall.com)
Leydig1
- Thus only those substance that provoked a complete estrogen receptor response were observed to stimulate DNA synthesis in mouse testicular Leydig cells. (llu.edu)
Lymphatic1
- Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Histologically1
- The neoplasms may be histologically the same or different, and may be found in the same or different sites. (lookformedical.com)
