Takayasu Arteritis
HLA-B52 Antigen
Giant Cell Arteritis
Arteritis Virus, Equine
Subclavian Artery
Aortography
Voice Disorders
Temporal Arteries
Magnetic Resonance Angiography
Polymyalgia Rheumatica
Aortic Valve Insufficiency
Glucocorticoids
Tomography, X-Ray Computed
Vasculitis
Systemic Vasculitis
Retinal Vasculitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Inflammation
Vasculitis, Central Nervous System
Polychondritis, Relapsing
Ear Deformities, Acquired
Tracheobronchomalacia
Ear, Inner
Sweet Syndrome
Endovascular stent graft repair of aortopulmonary fistula. (1/283)
Two patients who had aortopulmonary fistula of postoperative origin with hemoptysis underwent successful repair by means of an endovascular stent graft procedure. One patient had undergone repeated thoracotomies two times, and the other one time to repair anastomotic aneurysms of the descending aorta after surgery for Takayasu's arteritis. A self-expanding stainless steel stent covered with a Dacron graft was inserted into the lesion through the external iliac or femoral artery. The patients recovered well, with no signs of infection or recurrent hemoptysis 8 months after the procedure. Endovascular stent grafting may be a therapeutic option for treating patients with aortopulmonary fistula. (+info)Intimal tear without hematoma: an important variant of aortic dissection that can elude current imaging techniques. (2/283)
BACKGROUND: The modern imaging techniques of transesophageal echocardiography, CT, and MRI are reported to have up to 100% sensitivity in detecting the classic class of aortic dissection; however, anecdotal reports of patient deaths from a missed diagnosis of subtle classes of variants are increasingly being noted. METHODS AND RESULTS: In a series of 181 consecutive patients who had ascending or aortic arch repairs, 9 patients (5%) had subtle aortic dissection not diagnosed preoperatively. All preoperative studies in patients with missed aortic dissection were reviewed in detail. All 9 patients (2 with Marfan syndrome, 1 with Takayasu's disease) with undiagnosed aortic dissection had undergone >/=3 imaging techniques, with the finding of ascending aortic dilatation (4.7 to 9 cm) in all 9 and significant aortic valve regurgitation in 7. In 6 patients, an eccentric ascending aortic bulge was present but not diagnostic of aortic dissection on aortography. At operation, aortic dissection tears were limited in extent and involved the intima without extensive undermining of the intima or an intimal "flap." Eight had composite valve grafts inserted, and all survived. Of the larger series of 181 patients, 98% (179 of 181) were 30-day survivors. CONCLUSIONS: In patients with suspected aortic dissection not proven by modern noninvasive imaging techniques, further study should be performed, including multiple views of the ascending aorta by aortography. If patients have an ascending aneurysm, particularly if eccentric on aortography and associated with aortic valve regurgitation, an urgent surgical repair should be considered, with excellent results expected. (+info)Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? (3/283)
BACKGROUND: In patients with Takayasu arteritis, circulating lymphocytes are activated, and histological findings indicate that cell-mediated immunity plays an important role in the pathogenetic sequence leading to vascular lesions. METHODS AND RESULTS: To delineate the profile of inflammatory and chemoattractant cytokines involved in T-cell activation in Takayasu arteritis, we measured by ELISA serum levels of interleukin (IL)-6, IL-1beta, and RANTES in 18 patients. Subsequently, we wanted to establish whether any of these molecules could be used as a marker to monitor the clinical course of the disease and to predict disease exacerbations. We found that all patients with Takayasu arteritis studied during an active phase of the disease have increased serum concentration of IL-6 compared with healthy control subjects (P<0.01). Enhanced IL-6 serum levels paralleled disease activity to the extent that its serum concentrations were comparable to those of control subjects when patients were studied in remission. RANTES concentrations were also higher than normal in the serum of all patients with Takayasu arteritis (P<0.01) studied during an active phase of the disease. RANTES serum levels tended to normalize in remission, but values remained higher than those of control subjects (P<0.05). In contrast, serum concentrations of IL-1beta were below the detection limit of ELISA in both healthy subjects and all patients with Takayasu arteritis. A positive correlation was found between either IL-6 (rho=0.705, P<0.01) or RANTES (rho=0.607, P<0.05) serum level and disease activity. CONCLUSIONS: The close correlation of serum IL-6 and RANTES levels with disease activity suggests that these cytokines contribute to vasculitic lesions in Takayasu arteritis and raises the possibility that their monitoring in serum helps clinicians find adequate treatment adjustments in individual patients. (+info)Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels. (4/283)
OBJECTIVE: To create monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis to evaluate their ability to activate human umbilical vein endothelial cells (HUVEC), and to characterize the mechanism of EC activation. METHODS: A panel of mAECA was generated from peripheral blood lymphocytes of a patient with Takayasu arteritis, using Epstein-Barr virus transformation. Activity against macrovascular EC (HUVEC) and microvascular EC (human bone marrow EC immortalized by SV40) antigens was detected by enzyme-linked immunosorbent assay. Inhibition studies were used to select the monoclonal antibodies (mAECA) which share the same EC epitope binding specificity as the total IgG-AECA from the Takayasu arteritis patient. The binding of the mAECA to human aortic EC was studied by immunohistochemistry. The secretion levels of interleukin-6 (IL-6) and von Willebrand factor (vWF) were determined, to serve as markers for EC activation. The activated EC were examined for the adherence of a monocytic cell line (U937), as well as for expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and E-selectin. In addition, nuclear extracts of the mAECA-treated EC were analyzed for the induction of translocation of nuclear factor kappaB (NF-kappaB), using a specific NF-kappaB oligoprobe in an electrophoretic mobility shift assay. RESULTS: Six mAECA were selected, the mixture of which produced 100% inhibition of binding of the original IgG (from the patient with Takayasu arteritis) to HUVEC. All mAECA possessed high activity against macrovascular EC, but none had significant antimicrovascular EC activity. The mAECA, but not normal human IgG, had anti-human aortic EC activity. Four of the 6 mAECA activated EC, manifested by increased IL-6 and vWF secretion. The 4 mAECA induced EC expression of adhesion molecules and increased adhesion of U937 monocytic cells to EC. In addition, these mAECA stimulated the nuclear translocation of the NF-kappaB transcription factor. CONCLUSION: Our findings suggest that AECA may directly stimulate EC in Takayasu arteritis through elevation of adhesion molecule expression associated with NF-kappaB activation and adhesion of monocytes, and may therefore play a pathogenic role in the development of the vasculopathy in Takayasu arteritis. (+info)Cryopreserved aortic homograft replacement in a patient with Takayasu's arteritis. (5/283)
A patient with severe long-standing Takayasu's arteritis underwent successful replacement of the aortic root and ascending aorta with a cryopreserved aortic homograft. Her postoperative course was uneventful and echocardiography demonstrated evidence of neither aortic regurgitation nor graft detachment more than 2 years after the operation. Magnetic resonance image demonstrated no signs of graft enlargement. (+info)The acute diagnosis of Takayasu's arteritis based on helical CT angiography of the chest and neck in the emergency room. (6/283)
Recently, a young woman presented acutely with a left hemispheric stroke and differing blood pressures in the arms as her initial manifestation of Takayasu's arteritis. Helical CT angiography, performed to rule out aortic dissection, revealed a thickened wall of the aortic arch with stenoses and occlusions of the great vessels, suggesting the diagnosis. The sequence of imaging studies and findings in this unusually catastrophic presentation of a typically insidious disease are highlighted. (+info)Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases: antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus. (7/283)
OBJECTIVE: To study the frequency and disease specificity of antinucleosome antibody reactivity in diverse connective tissue diseases (CTD), and to determine factors, such as antibody subclass, that may influence the pathogenicity of these antibodies in relation to disease activity. METHODS: IgG and IgM antinucleosome activities on nucleosome core particles from 496 patients with 13 different CTD and 100 patients with hepatitis C were measured by enzyme-linked immunosorbent assay (ELISA). Of the patients with CTD, 120 had systemic lupus erythematosus (SLE), 37 had scleroderma (systemic sclerosis; SSc), 20 had mixed connective tissue disease (MCTD), and 319 had other CTD, including Sjogren's syndrome, inflammatory myopathy, rheumatoid arthritis, primary antiphospholipid syndrome, Wegener's granulomatosis, Takayasu arteritis, giant cell arteritis, relapsing polychondritis, Behcet's syndrome, and sarcoidosis. Antinucleosome-positive sera were further analyzed, by isotype-specific ELISA, for antinucleosome and anti-double-stranded DNA (anti-dsDNA) IgG subclasses. RESULTS: SLE, SSc, and MCTD were the only 3 CTD in which antinucleosome IgG were detected (71.7%, 45.9%, and 45.0% of patients, respectively). Antinucleosomes of the IgG3 subclass were present at high levels in patients with active SLE and were virtually absent in those with SSc, MCTD, or inactive SLE, and their levels showed a positive correlation with SLE disease activity. Of note, an increase in levels of antinucleosome of the IgG3 isotype was observed during SLE flares, and this increase was found to be closely associated with active nephritis. Levels of antinucleosome of the IgG1 subclass showed a trend toward an inverse correlation with SLE disease activity. No significant fluctuation in the anti-dsDNA isotype profile was observed in relation to SLE severity or clinical signs. CONCLUSION: Our data suggest that IgG antinucleosome is a new marker that may help in the differential diagnosis of CTD; antinucleosome of the IgG3 isotype might constitute a selective biologic marker of active SLE, in particular, of lupus nephritis. (+info)Takayasu's arteritis in a 69 year-old woman. (8/283)
Takayasu's arteritis and temporal arteritis share many clinical and pathological features. The most discriminatory feature between the two diseases is the age at onset; the mean age at onset of the disease was reported as being 26 years for Takayasu's arteritis and 69 years for temporal arteritis. Here we report a 69-year-old woman who presented with a weak right radial artery pulse. The ethnic background and the presence of vascular insufficiency of the right upper extremity and the absence of clinical signs such as shoulder stiffness and tender scalp indicate that her diagnosis is Takayasu's arteritis. It must be emphasized that the two conditions could be differentiated based on the clinical findings even in a patient as old as 69 years old. (+info)Takayasu arteritis is a rare inflammatory disease that affects the large blood vessels in the body, most commonly the aorta and its main branches. It's also known as pulseless disease or aortic arch syndrome. The condition primarily affects young to middle-aged women, although it can occur in anyone at any age.
The inflammation caused by Takayasu arteritis can lead to narrowing, thickening, and weakening of the affected blood vessels' walls, which can result in reduced blood flow to various organs and tissues. This can cause a variety of symptoms depending on the severity and location of the vessel involvement.
Common symptoms include:
* Weak or absent pulses in the arms and/or legs
* High blood pressure (hypertension)
* Dizziness, lightheadedness, or fainting spells due to reduced blood flow to the brain
* Headaches
* Visual disturbances
* Fatigue
* Weight loss
* Night sweats
* Fever
Diagnosis of Takayasu arteritis typically involves a combination of medical history, physical examination, laboratory tests, and imaging studies. Treatment usually includes corticosteroids or other immunosuppressive medications to control inflammation and maintain remission. Regular follow-up with a healthcare provider is essential to monitor disease activity and adjust treatment as necessary.
HLA-B52 is a specific antigen of the human leukocyte antigen (HLA) system, which is located on chromosome 6 and plays an important role in the immune system. The HLA system helps the body to recognize and distinguish its own cells from foreign substances such as viruses and bacteria.
HLA-B52 is a type of HLA-B antigen, which is a group of proteins found on the surface of cells that help the immune system identify and destroy infected or damaged cells. The HLA-B52 antigen is most commonly found in individuals of Asian descent, particularly those from Japan and Korea.
It's important to note that the presence or absence of the HLA-B52 antigen does not necessarily indicate the presence or absence of a specific disease. However, certain genetic associations have been reported between HLA-B52 and some diseases such as Behçet's disease, which is a chronic inflammatory disorder that causes symptoms such as mouth sores, genital sores, eye inflammation, and skin lesions.
Arteritis is a medical condition characterized by inflammation of the arteries. It is also known as vasculitis of the arteries. The inflammation can cause the walls of the arteries to thicken and narrow, reducing blood flow to affected organs or tissues. There are several types of arteritis, including:
1. Giant cell arteritis (GCA): Also known as temporal arteritis, it is a condition that mainly affects the large and medium-sized arteries in the head and neck. The inflammation can cause headaches, jaw pain, scalp tenderness, and vision problems.
2. Takayasu's arteritis: This type of arteritis affects the aorta and its major branches, mainly affecting young women. Symptoms include fever, weight loss, fatigue, and decreased pulse in the arms or legs.
3. Polyarteritis nodosa (PAN): PAN is a rare systemic vasculitis that can affect medium-sized arteries throughout the body. It can cause a wide range of symptoms, including fever, rash, abdominal pain, and muscle weakness.
4. Kawasaki disease: This is a type of arteritis that mainly affects children under the age of 5. It causes inflammation in the blood vessels throughout the body, leading to fever, rash, swollen lymph nodes, and red eyes.
The exact cause of arteritis is not fully understood, but it is believed to be an autoimmune disorder, where the body's immune system mistakenly attacks its own tissues. Treatment for arteritis typically involves medications to reduce inflammation and suppress the immune system.
Giant Cell Arteritis (GCA), also known as Temporal Arteritis, is a chronic inflammatory disease affecting large and medium-sized arteries, most commonly the temporal artery. It primarily occurs in people over 50 years old. The condition is characterized by the infiltration of the artery walls with immune cells, leading to inflammation, swelling, and damage. This can restrict blood flow, causing various symptoms.
The key feature of GCA is the presence of multinucleated giant cells, which are large collections of fused immune cells, in the affected artery walls. These cells are a hallmark of this condition when viewed under a microscope.
Common symptoms include new onset of severe headaches, scalp tenderness, jaw pain while chewing (called jaw claudication), vision problems, and systemic symptoms such as fever, fatigue, and weight loss. If left untreated, GCA can lead to serious complications like blindness or stroke. Treatment typically involves high-dose corticosteroids to reduce inflammation and prevent further damage.
Aortitis is a medical condition characterized by inflammation of the aorta, which is the largest artery in the body that carries oxygenated blood from the heart to the rest of the body. The inflammation can cause damage to the aortic wall, leading to weakening, bulging (aneurysm), or tearing (dissection) of the aorta. Aortitis can be caused by various conditions, including infections, autoimmune diseases, and certain medications. It is essential to diagnose and treat aortitis promptly to prevent serious complications.
I'm sorry for any confusion, but there seems to be a mistake in your question. "Arteritis Virus, Equine" is not a recognized medical term or virus in humans or animals. There is a condition called "Equine Viral Arteritis (EVA)," which is a viral disease that affects horses and other equine species. However, it does not affect humans.
Equine Viral Arteritis (EVA) is caused by the Equine Arteritis Virus (EAV). This virus primarily affects the respiratory system and can cause symptoms such as fever, lethargy, loss of appetite, and a runny nose in infected horses. In some cases, it may also lead to inflammation of the lining of blood vessels (vasculitis), which can result in abortion in pregnant mares or infertility in stallions.
It's essential to maintain proper biosecurity measures when dealing with horses, especially those that have been exposed to EVA, to prevent its spread and protect the health of other equine populations.
The subclavian artery is a major blood vessel that supplies the upper limb and important structures in the neck and head. It arises from the brachiocephalic trunk (in the case of the right subclavian artery) or directly from the aortic arch (in the case of the left subclavian artery).
The subclavian artery has several branches, including:
1. The vertebral artery, which supplies blood to the brainstem and cerebellum.
2. The internal thoracic artery (also known as the mammary artery), which supplies blood to the chest wall, breast, and anterior mediastinum.
3. The thyrocervical trunk, which gives rise to several branches that supply the neck, including the inferior thyroid artery, the suprascapular artery, and the transverse cervical artery.
4. The costocervical trunk, which supplies blood to the neck and upper back, including the posterior chest wall and the lower neck muscles.
The subclavian artery is a critical vessel in maintaining adequate blood flow to the upper limb, and any blockage or damage to this vessel can lead to significant morbidity, including arm pain, numbness, weakness, or even loss of function.
Aortography is a medical procedure that involves taking X-ray images of the aorta, which is the largest blood vessel in the body. The procedure is usually performed to diagnose or assess various conditions related to the aorta, such as aneurysms, dissections, or blockages.
To perform an aortography, a contrast dye is injected into the aorta through a catheter that is inserted into an artery, typically in the leg or arm. The contrast dye makes the aorta visible on X-ray images, allowing doctors to see its structure and any abnormalities that may be present.
The procedure is usually performed in a hospital or outpatient setting and may require sedation or anesthesia. While aortography can provide valuable diagnostic information, it also carries some risks, such as allergic reactions to the contrast dye, damage to blood vessels, or infection. Therefore, it is typically reserved for situations where other diagnostic tests have been inconclusive or where more invasive treatment may be required.
Voice disorders are conditions that affect the quality, pitch, or volume of a person's voice. These disorders can result from damage to or abnormalities in the vocal cords, which are the small bands of muscle located in the larynx (voice box) that vibrate to produce sound.
There are several types of voice disorders, including:
1. Vocal cord dysfunction: This occurs when the vocal cords do not open and close properly, resulting in a weak or breathy voice.
2. Vocal cord nodules: These are small growths that form on the vocal cords as a result of excessive use or misuse of the voice, such as from shouting or singing too loudly.
3. Vocal cord polyps: These are similar to nodules but are usually larger and can cause more significant changes in the voice.
4. Laryngitis: This is an inflammation of the vocal cords that can result from a viral infection, overuse, or exposure to irritants such as smoke.
5. Muscle tension dysphonia: This occurs when the muscles around the larynx become tense and constricted, leading to voice changes.
6. Paradoxical vocal fold movement: This is a condition in which the vocal cords close when they should be open, causing breathing difficulties and a weak or breathy voice.
7. Spasmodic dysphonia: This is a neurological disorder that causes involuntary spasms of the vocal cords, resulting in voice breaks and difficulty speaking.
Voice disorders can cause significant impairment in communication, social interactions, and quality of life. Treatment may include voice therapy, medication, or surgery, depending on the underlying cause of the disorder.
Temporal arteries are the paired set of arteries that run along the temples on either side of the head. They are branches of the external carotid artery and play a crucial role in supplying oxygenated blood to the scalp and surrounding muscles. One of the most common conditions associated with temporal arteries is Temporal Arteritis (also known as Giant Cell Arteritis), which is an inflammation of these arteries that can lead to serious complications like vision loss if not promptly diagnosed and treated.
Angiography is a medical procedure in which an x-ray image is taken to visualize the internal structure of blood vessels, arteries, or veins. This is done by injecting a radiopaque contrast agent (dye) into the blood vessel using a thin, flexible catheter. The dye makes the blood vessels visible on an x-ray image, allowing doctors to diagnose and treat various medical conditions such as blockages, narrowing, or malformations of the blood vessels.
There are several types of angiography, including:
* Cardiac angiography (also called coronary angiography) - used to examine the blood vessels of the heart
* Cerebral angiography - used to examine the blood vessels of the brain
* Peripheral angiography - used to examine the blood vessels in the limbs or other parts of the body.
Angiography is typically performed by a radiologist, cardiologist, or vascular surgeon in a hospital setting. It can help diagnose conditions such as coronary artery disease, aneurysms, and peripheral arterial disease, among others.
Magnetic Resonance Angiography (MRA) is a non-invasive medical imaging technique that uses magnetic fields and radio waves to create detailed images of the blood vessels or arteries within the body. It is a type of Magnetic Resonance Imaging (MRI) that focuses specifically on the circulatory system.
MRA can be used to diagnose and evaluate various conditions related to the blood vessels, such as aneurysms, stenosis (narrowing of the vessel), or the presence of plaques or tumors. It can also be used to plan for surgeries or other treatments related to the vascular system. The procedure does not use radiation and is generally considered safe, although people with certain implants like pacemakers may not be able to have an MRA due to safety concerns.
Convalescence is the period of recovery following a serious illness, injury, or medical treatment. During this time, the body gradually returns to its normal state of health and functioning. The length and intensity of the convalescent period can vary widely depending on the individual and the severity of the condition that required treatment.
During convalescence, it is important for individuals to take care of themselves and allow their bodies to heal properly. This may involve getting plenty of rest, eating a healthy diet, engaging in gentle exercise or physical therapy as recommended by a healthcare provider, and avoiding strenuous activities or stressors that could hinder recovery.
Convalescence is an essential part of the healing process, and it is important to allow oneself enough time to fully recover before returning to normal activities. Rushing the convalescent period can lead to setbacks, complications, or a prolonged recovery time. By taking the time to focus on self-care and healing during convalescence, individuals can help ensure a full and speedy recovery.
Polymyalgia Rheumatica (PMR) is a geriatric rheumatic disease characterized by widespread musculoskeletal pain and stiffness, particularly affecting the neck, shoulders, hips, and thighs. It is often accompanied by symptoms such as fatigue, weakness, loss of appetite, and low-grade fever. The onset of PMR can be sudden or gradual, and it tends to affect individuals over 50 years of age, more commonly women than men.
The exact cause of Polymyalgia Rheumatica remains unknown; however, it is believed to involve an autoimmune response leading to inflammation in the affected areas. Diagnosis typically involves a combination of clinical evaluation, laboratory tests (such as elevated erythrocyte sedimentation rate or C-reactive protein), and sometimes imaging studies. Treatment usually includes corticosteroids to reduce inflammation and manage symptoms, along with monitoring for potential side effects from long-term steroid use. In many cases, PMR can be successfully managed with appropriate treatment, allowing individuals to return to their normal activities.
Aortic valve insufficiency, also known as aortic regurgitation or aortic incompetence, is a cardiac condition in which the aortic valve does not close properly during the contraction phase of the heart cycle. This allows blood to flow back into the left ventricle from the aorta, instead of being pumped out to the rest of the body. As a result, the left ventricle must work harder to maintain adequate cardiac output, which can lead to left ventricular enlargement and heart failure over time if left untreated.
The aortic valve is a trileaflet valve that lies between the left ventricle and the aorta. During systole (the contraction phase of the heart cycle), the aortic valve opens to allow blood to be pumped out of the left ventricle into the aorta and then distributed to the rest of the body. During diastole (the relaxation phase of the heart cycle), the aortic valve closes to prevent blood from flowing back into the left ventricle.
Aortic valve insufficiency can be caused by various conditions, including congenital heart defects, infective endocarditis, rheumatic heart disease, Marfan syndrome, and trauma. Symptoms of aortic valve insufficiency may include shortness of breath, fatigue, chest pain, palpitations, and edema (swelling). Diagnosis is typically made through physical examination, echocardiography, and other imaging studies. Treatment options depend on the severity of the condition and may include medication, surgery to repair or replace the aortic valve, or a combination of both.
Glucocorticoids are a class of steroid hormones that are naturally produced in the adrenal gland, or can be synthetically manufactured. They play an essential role in the metabolism of carbohydrates, proteins, and fats, and have significant anti-inflammatory effects. Glucocorticoids suppress immune responses and inflammation by inhibiting the release of inflammatory mediators from various cells, such as mast cells, eosinophils, and lymphocytes. They are frequently used in medical treatment for a wide range of conditions, including allergies, asthma, rheumatoid arthritis, dermatological disorders, and certain cancers. Prolonged use or high doses of glucocorticoids can lead to several side effects, such as weight gain, mood changes, osteoporosis, and increased susceptibility to infections.
X-ray computed tomography (CT or CAT scan) is a medical imaging method that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of the body. These cross-sectional images can then be used to display detailed internal views of organs, bones, and soft tissues in the body.
The term "computed tomography" is used instead of "CT scan" or "CAT scan" because the machines take a series of X-ray measurements from different angles around the body and then use a computer to process these data to create detailed images of internal structures within the body.
CT scanning is a noninvasive, painless medical test that helps physicians diagnose and treat medical conditions. CT imaging provides detailed information about many types of tissue including lung, bone, soft tissue and blood vessels. CT examinations can be performed on every part of the body for a variety of reasons including diagnosis, surgical planning, and monitoring of therapeutic responses.
In computed tomography (CT), an X-ray source and detector rotate around the patient, measuring the X-ray attenuation at many different angles. A computer uses this data to construct a cross-sectional image by the process of reconstruction. This technique is called "tomography". The term "computed" refers to the use of a computer to reconstruct the images.
CT has become an important tool in medical imaging and diagnosis, allowing radiologists and other physicians to view detailed internal images of the body. It can help identify many different medical conditions including cancer, heart disease, lung nodules, liver tumors, and internal injuries from trauma. CT is also commonly used for guiding biopsies and other minimally invasive procedures.
In summary, X-ray computed tomography (CT or CAT scan) is a medical imaging technique that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional images of the body. It provides detailed internal views of organs, bones, and soft tissues in the body, allowing physicians to diagnose and treat medical conditions.
Vasculitis is a group of disorders characterized by inflammation of the blood vessels, which can cause changes in the vessel walls including thickening, narrowing, or weakening. These changes can restrict blood flow, leading to organ and tissue damage. The specific symptoms and severity of vasculitis depend on the size and location of the affected blood vessels and the extent of inflammation. Vasculitis can affect any organ system in the body, and its causes can vary, including infections, autoimmune disorders, or exposure to certain medications or chemicals.
Systemic vasculitis is a group of disorders characterized by inflammation of the blood vessels (vasculitis) that can affect various organs and systems throughout the body. This condition can cause damage to the walls of the blood vessels, leading to narrowing, blockage, or weakening of the vessel walls, which can further result in reduced blood flow, tissue damage, and organ dysfunction.
The symptoms of systemic vasculitis depend on the severity and location of the affected blood vessels. They may include fever, fatigue, weight loss, joint pain, skin rashes or lesions, muscle weakness, nerve damage, and organ dysfunction such as kidney failure, lung disease, or gastrointestinal bleeding.
Systemic vasculitis can be caused by various factors, including infections, autoimmune diseases, medications, and underlying medical conditions. The diagnosis of systemic vasculitis typically involves a combination of physical examination, laboratory tests, imaging studies, and sometimes biopsy of the affected tissue. Treatment may include corticosteroids, immunosuppressive drugs, and other medications to control inflammation and prevent organ damage.
"Foreign bodies" refer to any object or substance that is not normally present in a particular location within the body. These can range from relatively harmless items such as splinters or pieces of food in the skin or gastrointestinal tract, to more serious objects like bullets or sharp instruments that can cause significant damage and infection.
Foreign bodies can enter the body through various routes, including ingestion, inhalation, injection, or penetrating trauma. The location of the foreign body will determine the potential for harm and the necessary treatment. Some foreign bodies may pass through the body without causing harm, while others may require medical intervention such as removal or surgical extraction.
It is important to seek medical attention if a foreign body is suspected, as untreated foreign bodies can lead to complications such as infection, inflammation, and tissue damage.
Retinal vasculitis is a medical condition characterized by inflammation of the blood vessels in the retina, which is the light-sensitive tissue located at the back of the eye. This condition can cause damage to the retina and may lead to vision loss if not treated promptly. The inflammation can affect both the small and large blood vessels in the retina and can occur as a result of various systemic diseases or infections, including autoimmune disorders, tuberculosis, syphilis, and toxoplasmosis. In some cases, retinal vasculitis may also be associated with uveitis, which is inflammation of the middle layer of the eye. Treatment typically involves addressing the underlying cause of the inflammation and may include corticosteroids or other immunosuppressive therapies to reduce inflammation and prevent further damage to the retina.
Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (AAV) is a group of autoimmune diseases characterized by inflammation and damage to small blood vessels, particularly capillaries, venules, and arterioles. The condition is named after the presence of ANCAs in the patient's serum, which are autoantibodies that target specific proteins in the neutrophil cytoplasm.
AAV includes several subtypes, including:
1. Granulomatosis with Polyangiitis (GPA, formerly known as Wegener's granulomatosis) - a form of AAV that typically affects the respiratory tract and kidneys, characterized by the presence of granulomas (clusters of inflammatory cells).
2. Microscopic Polyangiitis (MPA) - a form of AAV that primarily affects small vessels in various organs, such as the kidneys, lungs, and skin.
3. Eosinophilic Granulomatosis with Polyangiitis (EGPA, formerly known as Churg-Strauss syndrome) - a form of AAV that involves asthma, allergies, and eosinophilia (an increased number of eosinophils in the blood), along with vasculitis affecting various organs.
The exact cause of ANCA-Associated Vasculitis is not fully understood, but it is believed to involve an interplay between genetic factors, environmental triggers, and dysregulation of the immune system. The condition can lead to a wide range of symptoms depending on which organs are affected, including fever, fatigue, weight loss, joint pain, skin rashes, cough, shortness of breath, nosebleeds, and kidney problems. Treatment typically involves immunosuppressive medications to control inflammation and prevent further damage to the affected organs.
Inflammation is a complex biological response of tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is characterized by the following signs: rubor (redness), tumor (swelling), calor (heat), dolor (pain), and functio laesa (loss of function). The process involves the activation of the immune system, recruitment of white blood cells, and release of inflammatory mediators, which contribute to the elimination of the injurious stimuli and initiation of the healing process. However, uncontrolled or chronic inflammation can also lead to tissue damage and diseases.
Vasculitis, Central Nervous System (CNS), refers to a group of disorders characterized by inflammation of blood vessels within the brain and/or spinal cord. This inflammation can cause damage to the blood vessel walls, leading to narrowing, blocking or weakening of the vessels, and in some cases, formation of aneurysms or rupture of the vessels.
The causes of CNS vasculitis are varied and can include infections, autoimmune diseases, medications, and unknown factors. The symptoms of CNS vasculitis depend on the severity and location of the inflammation, and may include headache, seizures, stroke-like symptoms (such as weakness or numbness in the face, arms, or legs), cognitive changes, and in severe cases, coma.
Diagnosis of CNS vasculitis typically involves a combination of clinical evaluation, imaging studies (such as MRI or angiography), and laboratory tests (including blood tests and analysis of cerebrospinal fluid). Treatment may involve corticosteroids, immunosuppressive medications, and/or other therapies aimed at reducing inflammation and preventing further damage to the blood vessels.
Relapsing polychondritis is a rare autoimmune disease characterized by inflammation and damage to the cartilaginous structures in the body. The condition can affect multiple organs and tissues, including the ears, nose, trachea, bronchi, joints, and cardiovascular system. It is called "relapsing" because it tends to involve recurring episodes of inflammation and damage, followed by periods of remission.
The hallmark symptom of relapsing polychondritis is pain and swelling in the ears, nose, or airways. Other symptoms may include:
* Redness, tenderness, and warmth in affected areas
* Hearing loss or tinnitus (ringing in the ears)
* Nasal congestion, runny nose, or nosebleeds
* Hoarseness or difficulty speaking
* Wheezing, shortness of breath, or coughing
* Joint pain, stiffness, or swelling
* Skin rashes or sores
* Eye inflammation or dryness
* Heart murmurs or other cardiovascular symptoms
The exact cause of relapsing polychondritis is not known, but it is thought to involve an abnormal immune response in which the body's own antibodies attack and damage cartilage and other tissues. The diagnosis of relapsing polychondritis is typically based on a combination of clinical symptoms, laboratory tests, and imaging studies.
There is no cure for relapsing polychondritis, but treatment can help manage the symptoms and prevent complications. Treatment may include corticosteroids, immunosuppressive drugs, and other medications to reduce inflammation and suppress the immune system. In severe cases, surgery may be necessary to repair or replace damaged tissues.
Ear cartilage, also known as auricular cartilage, refers to the flexible connective tissue that makes up the structural framework of the external ear or pinna. The ear cartilage provides support and shape to the ear, helping to direct sound waves into the ear canal and towards the eardrum.
The ear cartilage is composed of type II collagen fibers and proteoglycans, which give it its flexibility and resiliency. It is covered by a thin layer of skin on both sides and contains no bones. Instead, the ear cartilage is shaped and maintained by the surrounding muscles and connective tissue.
There are three main parts of the ear cartilage: the helix, the antihelix, and the tragus. The helix is the outer rim of the ear, while the antihelix is the curved ridge that runs parallel to the helix. The tragus is the small piece of cartilage that projects from the front of the ear canal.
Ear cartilage can be affected by various conditions, including trauma, infection, and degenerative changes associated with aging. In some cases, surgical procedures may be required to reshape or reconstruct damaged ear cartilage.
Acquired ear deformities refer to abnormal shapes or structures of the ear that result from injury, infection, inflammation, or other external factors after birth. These deformities can affect the appearance and function of the ear, causing symptoms such as hearing loss or discomfort. Examples of acquired ear deformities include:
1. Cauliflower ear: a condition characterized by swelling, thickening, and distortion of the ear caused by repeated trauma or injury to the ear cartilage.
2. Microtia: a congenital ear abnormality that can become worse over time due to infection, inflammation, or trauma, resulting in an underdeveloped or absent ear.
3. Macrotia: an abnormally large ear that may result from injury or other external factors.
4. Stenosis: a narrowing of the ear canal that can result from chronic inflammation, infection, or scarring.
5. Hematoma: a collection of blood in the ear tissue caused by trauma or injury, which can lead to deformity if not treated promptly.
6. Keloids: overgrowths of scar tissue that can form after injury or surgery and distort the shape of the ear.
Treatment for acquired ear deformities may include surgical reconstruction, splinting, or other interventions depending on the severity and underlying cause of the condition.
Tracheobronchomalacia is a medical condition that refers to the abnormal softening and weakness of the tracheal and bronchial walls, leading to their collapse or narrowing during breathing, particularly during expiration. This collapse can cause symptoms such as wheezing, shortness of breath, coughing, and recurrent respiratory infections. The condition can be congenital or acquired, with common causes including aging, chronic obstructive pulmonary disease (COPD), and long-term intubation. In severe cases, tracheobronchomalacia may require surgical intervention to stabilize the airway and improve breathing.
The inner ear is the innermost part of the ear that contains the sensory organs for hearing and balance. It consists of a complex system of fluid-filled tubes and sacs called the vestibular system, which is responsible for maintaining balance and spatial orientation, and the cochlea, a spiral-shaped organ that converts sound vibrations into electrical signals that are sent to the brain.
The inner ear is located deep within the temporal bone of the skull and is protected by a bony labyrinth. The vestibular system includes the semicircular canals, which detect rotational movements of the head, and the otolith organs (the saccule and utricle), which detect linear acceleration and gravity.
Damage to the inner ear can result in hearing loss, tinnitus (ringing in the ears), vertigo (a spinning sensation), and balance problems.
Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a skin condition characterized by the rapid onset of painful, red, and swollen skin lesions. The lesions are often accompanied by fever and elevated white blood cell count, particularly an increase in neutrophils.
The medical definition of Sweet syndrome includes the following criteria:
1. Abrupt onset of painful, erythematous (red), and edematous (swollen) papules, plaques, or nodules.
2. Fever greater than 38°C (100.4°F).
3. Leukocytosis with a predominance of neutrophils in the peripheral blood.
4. Histopathological evidence of a dense dermal infiltrate of neutrophils without evidence of vasculitis.
5. Rapid response to systemic corticosteroids.
Sweet syndrome can be associated with various medical conditions, such as infections, malignancies, and inflammatory diseases, or it can occur without an identifiable underlying cause (idiopathic).
Takayasu's arteritis - Wikipedia
Takayasu's arteritis - Diagnosis & treatment - Mayo Clinic
Takayasu Arteritis: Practice Essentials, Background, Pathophysiology
Takayasu's arteritis (pulseless disease) | Diagnosaurus
Increased risk of malignancy in patients with Takayasu's arteritis: a population-based cohort study in Korea | Scientific...
Takayasu arteritis
Videos: Focus on Takayasu Arteritis - Vasculitis Foundation
Pages that link to "Takayasu's arteritis historical perspective" - wikidoc
Surgical treatment of cerebral ischaemia caused by cervical arterial lesions due to Takayasu's arteritis: preliminary results...
Takayasu Arteritis - Bone, Joint, and Muscle Disorders - Merck Manuals Consumer Version
Longterm Outcomes of Renal Artery Involvement in Takayasu Arteritis | The Journal of Rheumatology
Vasculitis: Treatment, symptoms, causes, and types
Takayasu's arteritis - Prevalence, Symptoms, and Complications
Extensive Takayasu Arteritis - Siemens Healthineers Bulgaria
PYODERMA GANGRENOSUM SECONDARY TO TAKAYASU'S ARTERITIS - Sumathi Publications
Percutaneous Transluminal Angioplasty for Brain Ischemia due to Takayasu's Arteritis.
Takayasu Arteritis - Bone, Joint, and Muscle Disorders - MSD Manual Consumer Version
Search Results - Mayo Clinic
Takayasu Arteritis-Evaluated by CT Angiography, IJSR, Call for Papers, Online Journal
Isolated Thoracic Aortic Takayasu Arteritis Presenting as Presumed Mobile Aortic Thrombus<...
Giant aortic aneurysm in a child with Takayasu arteritis | Cardiology in the Young | Cambridge Core
Bilateral carotid artery aneurysm presenting as pulsatile neck swelling: an unusual presentation of Takayasu's arteritis -...
Volume 13(8) 2007 (17)
Relapsing Polychondritis Treatment & Management: Medical Care, Surgical Care, Consultations
Aortic arch syndrome: MedlinePlus Medical Encyclopedia
Dr. Hemalatha Srinivasalu, MD - Pediatric Rheumatology Specialist in Washington, DC | Healthgrades
USMLE | Multisystem Processes & Disorders
Giant cell arte8
- Takayasu's arteritis is similar to other forms of vasculitis, including giant cell arteritis which typically affects older individuals. (wikipedia.org)
- Giant cell arteritis is the most common form of systemic vasculitis in people over the age of 50. (medicalxpress.com)
- Giant Cell Arteritis and Takayasu Arteritis: Are they a different spectrum of the same disease? (ox.ac.uk)
- Giant cell arteritis (GCA), or temporal arteritis, is an inflammation of your superficial temporal artery and the other arteries supplying blood to your head, eyes, and jaw. (healthline.com)
- This is almost invariably due to giant cell arteritis (GCA), which is a primary vasculitis that affects extracranial medium (especially external carotid artery-ECA-branches) and sometimes large arteries (aorta and its major branches)-large-vessel GCA [ 3 , 4 ]. (intechopen.com)
- Inflamed blood vessel diseases, such as Takayasu's and giant cell arteritis. (upmc.com)
- Giant cell arteritis occurs in those aged 50 years and over and seems to mainly affect persons of northern European ancestry, whereas Takayasu arteritis occurs mainly in those aged under 40 years. (lu.se)
- Although much less common than giant cell arteritis, the different forms of antineutrophil cytoplasmic antibody-associated vasculitis are being increasingly recognized in most populations and occur more frequently with increasing age. (lu.se)
Takayasu's Arteritis28
- Takayasu's arteritis (TA), also known as aortic arch syndrome, nonspecific aortoarteritis, and pulseless disease, is a form of large vessel granulomatous vasculitis with massive intimal fibrosis and vascular narrowing, most commonly affecting young or middle-aged women of Asian descent, though anyone can be affected. (wikipedia.org)
- In the Western world, atherosclerosis is a more frequent cause of obstruction of the aortic arch vessels than Takayasu's arteritis. (wikipedia.org)
- Due to obstruction of the main branches of the aorta, including the left common carotid artery, the brachiocephalic artery, and the left subclavian artery, Takayasu's arteritis can present as pulseless upper extremities (arms, hands, and wrists with weak or absent pulses on the physical examination) which may be why it is also commonly referred to as the "pulseless disease. (wikipedia.org)
- One rare, important feature of the Takayasu's arteritis is ocular involvement in form of visual field defects, vision loss, or retinal hemorrhage. (wikipedia.org)
- Some individuals with Takayasu's arteritis may present with only late vascular changes, without a preceding systemic illness. (wikipedia.org)
- citation needed] The genetic contribution to the pathogenesis of Takayasu's arteritis is supported by the genetic association with HLA-B∗52. (wikipedia.org)
- About 200,000 genetic variants were genotyped in two ethnically divergent Takayasu's arteritis cohorts from Turkey and North America by using a custom-designed genotyping platform (Immunochip). (wikipedia.org)
- He or she may also have you undergo some of the following tests and procedures to help rule out other conditions that resemble Takayasu's arteritis and to confirm the diagnosis. (mayoclinic.org)
- A person with Takayasu's arteritis generally has several areas of stenosis. (mayoclinic.org)
- Treatment of Takayasu's arteritis focuses on controlling inflammation with medications and preventing further damage to your blood vessels. (mayoclinic.org)
- Takayasu's arteritis can be difficult to treat because the disease may remain active even if your symptoms improve. (mayoclinic.org)
- For patient education information, see Takayasu's Arteritis . (medscape.com)
- Zeiger, Roni F.. "Takayasu's Arteritis (pulseless Disease). (unboundmedicine.com)
- This study aimed to evaluate the relative risk of malignancy in patients with Takayasu's arteritis compared to that in the general population. (nature.com)
- All newly diagnosed patients with Takayasu's arteritis were identified between January 2009 and December 2019. (nature.com)
- We identified 1449 newly diagnosed patients with Takayasu's arteritis during the observational period (9196 person-years). (nature.com)
- An increased risk of malignancy was observed in patients with Takayasu's arteritis compared to that in the general population in this large-scale nationwide population study of Korean health insurance data. (nature.com)
- Takayasu's arteritis is an uncommon form of vasculitis. (diseasesdic.com)
- Takayasu's arteritis is primarily a disease of adolescent girls and young women, who account for 80-90% of cases. (diseasesdic.com)
- In Takayasu's arteritis, the aorta and other major arteries, including those leading to the head and kidneys, become inflamed. (diseasesdic.com)
- Just what causes the initial inflammation in Takayasu's arteritis isn't known. (diseasesdic.com)
- It's likely that Takayasu's arteritis is an autoimmune disease in which the immune system malfunctions and attacks own arteries as if they were foreign substances. (diseasesdic.com)
- As with many other inflammatory diseases, patients with Takayasu's arteritis often feel ill with "flu-like" symptoms before the disease is treated. (diseasesdic.com)
- PG is associated with many systemic diseases, but association with Takayasu's arteritis (TA) / pulseless disease, which is chronic inflammatory and stenotic disease of large sized arteries is less common. (sumathipublications.com)
- Percutaneous Transluminal Angioplasty for Brain Ischemia due to Takayasu's Arteritis. (neurointervention.org)
- To report the follow-up results of percutaneous transluminal angioplasty (PTA) of supra-aortic arteries in patients presenting with neurological manifestations caused by Takayasu's arteritis. (neurointervention.org)
- PTA was performed in four consecutive patients (women, age range 33-38 years) with Takayasu's arteritis (TA) with neurological manifestations (i.e., stroke, visual disturbance, and dizziness) caused by stenoocclusive lesions of supra-aortic arteries. (neurointervention.org)
- 18F-fluorodeoxyglucose positron emission tomography showed increased uptake in the aortic arch, and its branches consistent with active, large vessel vasculitis (Panel D, Panel E) . She was treated with oral prednisolone 1 mg/kg and methotrexate 15 mg/week for active Takayasu's arteritis. (asiaintervention.org)
Pulseless2
- Shimizu and Sano reported six cases of Takayasu arteritis in an English-language publication in 1951, terming the disorder "pulseless disease because of an absence of radial pulse in their patients. (medscape.com)
- Takayasu arteritis, also referred to as pulseless disease and aortic arch syndrome, is a rare chronic inflammatory vasculitis that primarily affects large- and medium-sized vessels. (logicalimages.com)
Cause of Takayasu arteritis3
- citation needed] Although the cause of Takayasu arteritis is unknown, the condition is characterized by segmental and patchy granulomatous inflammation of the aorta and its major derivative branches. (wikipedia.org)
- No definitive cause of Takayasu arteritis has been identified, but it is thought to be an immunoglobulin G (IgG)-mediated autoimmune vasculitis, perhaps triggered by a cross-reacting infectious agent. (logicalimages.com)
- The cause of Takayasu arteritis is unknown. (merckmanuals.com)
Aorta9
- Takayasu arteritis is an inflammatory disease of large- and medium-sized arteries, with a predilection for the aorta and its branches. (medscape.com)
- Takayasu arteritis causes chronic blood vessel inflammation, mainly of the aorta (the artery that connects directly with the heart), the arteries that branch off from it, and the pulmonary arteries. (merckmanuals.com)
- Takayasu arteritis (TA) is a chronic, large vessel vasculitis that primarily affects the aorta and its main branches, including the renal artery 1 , 2 . (jrheum.org)
- Takayasu arteritis is a rare, chronic, idiopathic, granulomatous, inflammatory disease primarily involving large vessels like aorta and its major branches and pulmonary artery but can also involve coronary arteries. (ijsr.net)
- Isolated aortic mural thrombus (AMT) is an infrequent occurrence in the setting of an otherwise normal aorta and is a similarly rare occurrence in Takayasu arteritis (TAK). (elsevierpure.com)
- Takayasu arteritis is a chronic, idiopathic, granulomatous vasculitis involving the aorta, its major branches, and occasionally the pulmonary arteries. (cambridge.org)
- Takayasu arteritis is a type of large‐vessel vasculitis that affects the aorta-the main artery that carries blood away from the heart. (medicalxpress.com)
- Takayasu arteritis (TA) is a rare chronic vasculitis affecting the aorta and its main branches causing segmental and granulomatous inflammation. (cardiologyworldconference.com)
- Large vessel vasculitis, like Takayasu arteritis, affects the aorta and its major branches. (printo.it)
Known as aortic arch syndrome1
- Takeyasu's arteritis, also known as aortic arch syndrome or nonspecific aortoarteritis, predominately affects young to middle-aged females of Asian descent. (healthline.com)
Diagnosis1
- After satisfying the criteria for the diagnosis of Takayasu arteritis, she was referred to a rheumatologist who started her on glucocorticoids and azathioprine. (cardiologyworldconference.com)
Turkey and North America1
- Methods Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. (johnshopkins.edu)
Syndrome1
- An inflammatory disease called Takayasu syndrome may result in narrowing (stenosis) of the vessels of the aortic arch. (medlineplus.gov)
Chronic2
- In view of the chronic process and good collateral development, Raynaud's phenomenon or digital gangrene are very rare in Takayasu arteritis. (wikipedia.org)
- Takayasu arteritis is a chronic disorder with symptoms that fluctuate in severity. (merckmanuals.com)
Inflammatory1
- Takayasu arteritis is a rare, systemic, inflammatory large-vessel vasculitis of unknown etiology that most commonly affects women of childbearing age. (medscape.com)
Complications1
- The premature ischemic events experienced by our patient are believed to be complications of an undiagnosed Takayasu arteritis. (cardiologyworldconference.com)
Disease5
- Complete occlusion of the left common carotid artery in a 48-year-old woman with Takayasu disease. (medscape.com)
- Takayasu arteritis can manifest as isolated, atypical, and/or catastrophic disease. (medscape.com)
- Takayasu arteritis is named in honor of Japanese ophthalmologist Mikito Takayasu, who first reported a case of the disease in 1905. (medscape.com)
- Although aneurysmal disease has been reported in adults with Takayasu arteritis, it is a rare entity in children. (cambridge.org)
- As a result, patients with Takayasu arteritis experience long-term morbidity and mortality caused by cardiovascular disease. (cardiologyworldconference.com)
Inflammation1
- Arteritis refers to inflammation of your arteries that damages your blood vessel walls and reduces blood flow to your organs. (healthline.com)
Wegener1
- EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. (cambridge.org)
Pathophysiology1
- Conclusion Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis. (johnshopkins.edu)
Angiography1
- Takayasu arteritis (TA) was suspected and a Dual Energy (DE) whole body CT angiography (CTA) was performed for further investigation. (siemens-healthineers.com)
Symptoms1
- Like other forms of arteritis, PN often begins with a cluster of flu-like symptoms. (healthline.com)
Patients3
- however, it has been reported in patients as young as age 6 months (see Pediatric Takayasu Arteritis ). (medscape.com)
- Approximately 10% of patients with Takayasu arteritis are asymptomatic. (medscape.com)
- Patients with Takayasu arteritis are at increased risk for cardiovascular events due to premature and accelerated atherosclerosis. (cardiologyworldconference.com)
Vascular1
- This is also the first published case involving endovascular aortic graft placement for the management of vascular sequela of Takayasu arteritis in a child. (cambridge.org)
Rare2
- Takayasu arteritis is rare. (merckmanuals.com)
- Objective Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. (johnshopkins.edu)
Involvement1
- This led to a misunderstanding ot Takayasu arteritis as a disorder of only locally limited involvement. (medscape.com)
Renal1
- Takayasu arteritis (TA) involving the renal artery can result in hypertension (HTN), renal dysfunction, and premature death. (jrheum.org)
Genetic2
- Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis. (johnshopkins.edu)
- Results We identified genetic susceptibility loci for Takayasu arteritis with a genome-wide level of significance in IL6 (rs2069837) (odds ratio [OR] 2.07, P = 6.70 × 10 -9 ), RPS9/LILRB3 (rs11666543) (OR 1.65, P = 2.34 × 10 -8 ), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, P = 3.62 × 10 -10 ). (johnshopkins.edu)
Treatment1
- Rapid treatment is necessary to prevent organ damage from arteritis. (healthline.com)
Medications1
- Takeyasu's arteritis cannot be cured but can be managed to a certain extent with immunosuppressant medications. (healthline.com)
Criteria1
- Described here is a patient who presented with premature cardiovascular events, and was recently found to have fulfilled the diagnostic criteria for Takayasu arteritis. (cardiologyworldconference.com)