Systemic Vasculitis: A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Polyarteritis Nodosa: A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.Antibodies, Antineutrophil Cytoplasmic: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.Churg-Strauss Syndrome: Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.Wegener Granulomatosis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.Myeloblastin: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.Arteritis: INFLAMMATION of any ARTERIES.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Cogan Syndrome: A condition consisting of inflammatory eye disease usually presenting as interstitial KERATITIS, vestibuloauditory dysfunction, and large- to medium-vessel vasculitis.Cryoglobulinemia: A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.Vasculitis, Central Nervous System: Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Otorhinolaryngologic Diseases: Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Giant Cell Arteritis: A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Rheumatoid Vasculitis: Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.Leukemia, Myelomonocytic, Chronic: A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Respiratory Burst: A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Purpura: Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

*  Systemic Vasculitis

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*  RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides - Full Text View -

Vasculitis. Systemic Vasculitis. Granulomatosis with Polyangiitis. Microscopic Polyangiitis. Churg-Strauss Syndrome. Vascular ... Systemic ANCA positive (+) vasculitides. *Relapsing or refractory vasculitides, resistant to corticosteroids and reference ... RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides. This study has been completed. ... Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides With Positive ANCA After Relapse or Resistant ...

*  British Library EThOS: Characterisation of the autoantibody response in systemic vasculitis.

Medicine Medicine

*  Systemic Vasculitis In Progressive Systemic Sclerosis - Sclero Forums (MAIN) - Sclero Forums

Severity And Stages Of Vasculitis In Various Organs - A Retrospective Clinicopathologi... ... Systemic Vasculitis In Progressive Systemic Sclerosis: The Frequency, ... Systemic Vasculitis In Progressive Systemic Sclerosis: The Frequency, Severity And Stages Of Vasculitis In Various Organs - A ... The frequently involved gastrointestinal tract may be a good target for biopsy to confirm the presence of systemic vascular ...

*  IMPROVE: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis

... The aim of IMPROVE is to define the optimal maintenance therapy for ANCA-associated vasculitides (AASV) by ... ANCA Associated Systemic Vasculitis Including Wegener's. Intervention. Cyclophosphamide, Mycophenolate mofetil, Azathioprine, ... IMPROVE: Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis. 2014-08-27 ... Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy in ANCA Associated Systemic Vasculitis". *Related Companies* ...

*  Peroxiredoxin 2 is a novel autoantigen for anti-endothelial cell antibodies in systemic vasculitis.

... have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To understand the ... would be a useful marker for systemic vasculitis and would be involved in the inflammatory processes of systemic vasculitis. © ... was significantly higher in systemic vasculitis (60\%) compared to those in collagen diseases without clinical vasculitis (7 ... To understand the pathogenic roles of AECA in systemic vasculitis, we attempted to identify target antigens for AECA ...

*  Identification of an autoantibody to vascular endothelial cell-specific antigens in patients with systemic vasculitis.

Although immunologic mechanisms have been postulated in the pathogenesis of vasculitis, an autoimmune process directed against ... PATIENTS AND METHODS: The study patients included 21 with systemic vasculitis and four with hypersensitivity vasculitis. A ... RESULTS: An autoantibody to VEC antigens was detected in 18 of the 21 patients (86\%) with confirmed systemic vasculitis, not ... Identification of an autoantibody to vascular endothelial cell-specific antigens in patients with systemic vasculitis.. ...

*  Systemic Vasculitis During the Course of Systemic Sclerosis: Report of 12 Cases and Review of the Literature.

... has been reported in patients with systemic sclerosis (SSc), the association of SSc and systemic vasculitis has rarely been ... We obtained information on cases of systemic vasculitis associated with SSc in France from the French Vasculitis Study Group ... 9 with ANCA-associated systemic vasculitis (AASV) and 3 with mixed cryoglobulinemia vasculitis (MCV). In all AASV patients, SSc ... and all members of the French Research Group on Systemic Sclerosis.We identified 12 patients with systemic vasculitis ...

*  American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for...

Vasculitis. Arteritis. Systemic Vasculitis. Giant Cell Arteritis. Polymyalgia Rheumatica. Microscopic Polyangiitis. Takayasu ... Patients with primary systemic vasculitis or a mimic of these diseases seen in participating secondary or tertiary care centres ... Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187- ... One of the aims of this project is to develop diagnostic criteria for the primary systemic vasculitides (granulomatosis with ...

*  Pneumotox » Drug » Drug » X.m - Systemic vasculopathy/vasculitis (ANCA status unknown or negative)

Vasculitis in systemic lupus erythematosus following intravenous immunoglobulin therapy. Clinical and experimental rheumatology ...

*  Positive predictive value of anti-neutrophil cytoplasmic antibody (ANCA) testing for ANCA-associated systemic vasculitis (AASV)...

... testing for ANCA-associated systemic vasculitis (AASV) in a routine clinical setting Share Share Share Share ... Positive predictive value of anti-neutrophil cytoplasmic antibody (ANCA) testing for ANCA-associated systemic vasculitis (AASV ...

*  Pericardial effusion and vasculitis in a patient with systemic sclerosis.

Pleuropericarditis in systemic sclerosis may occur on the basis of vasculitis. Large pericardial effusions may predispose to ... Mechanical Haemolysis and Systemic Pressure. PPT Version , PDF Version. *Yener COSKUN MRICS. RISK MANAGEMENT AND RISK BASED ... This article was published in J Rheumatol and referenced in Journal of Vasculitis. Relevant Expert PPTs. ... Systemic Antimicrobial Prophylaxis Issues. PPT Version , PDF Version. *Trine N. Jorgensen. Myeloid cells as regulators of ...

*  Dr. Anne Beck, MD - Saint Louis, MO - Pediatric Nephrology & Nephrology & Pediatrics |

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*  Dr. Jai Radhakrishnan, MD - New York, NY - Nephrology |

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*  Dr. Rachel Mory, MD - Sylmar, CA - Rheumatology & Internal Medicine |

Systemic Sclerosis. *Systemic Vasculitis. *Temporal Arteritis. *Vascular Disease. *Vasculitis. *Wegener's Granulomatosis. ...

*  Dr. Daniel Soberon, MD - Lauderdale Lakes, FL - Nephrology |

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*  Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases - Full Text View -

Lupus Erythematosus, Systemic. Scleroderma, Systemic. Scleroderma, Diffuse. Vasculitis. Rheumatic Diseases. Arthritis, Juvenile ... Systemic Vasculitis Systemic Sclerosis (SSc) Sjögren's Syndrome Antiphospholipid Syndrome Juvenile Idiopathic Arthritis ... 150 with systemic vasculitis, 250 with systemic sclerosis (SSc) , 100 with Sjögren's syndrome, 100 with antiphospholipid ... Systemic Vasculitis. Disease. Pathologic Processes. Joint Diseases. Musculoskeletal Diseases. Autoimmune Diseases. Immune ...

*  Dr. Larry Moreland, MD - Pittsburgh, PA - Internal Medicine |

Systemic Sclerosis. *Systemic Vasculitis. *Temporal Arteritis. *Vascular Disease. *Vasculitis. *Wegener's Granulomatosis. More ...

*  Dr. Paul Gertler, MD - Ellicott City, MD - Rheumatology & Internal Medicine |

Systemic Sclerosis. *Systemic Vasculitis. *Temporal Arteritis. *Trigger Finger. *Vascular Disease. *Vasculitis. *Wegener's ...

*  Dr. Hom Neupane, MD - Syracuse, NY - Rheumatology & Internal Medicine |

Systemic Vasculitis. *Takayasu's Arteritis. *Temporal Arteritis. *Trigger Finger. *Vascular Disease. *Vasculitis. *Wegener's ...

*  Dr. Mashood Ahmad, MD - Rockford, IL - Nephrology & Internal Medicine |

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*  Dr. Soha Mousa, MD - Fairfield, OH - Rheumatology & Internal Medicine |

Systemic Sclerosis. *Systemic Vasculitis. *Temporal Arteritis. *Trigger Finger. *Vascular Disease. *Vasculitis. *Wegener's ...

*  Dr. Salam Gharaybeh, MD - Victoria, TX - Pediatric Nephrology & Nephrology & Pediatrics |

Systemic Vasculitis. *Traumatic Acute Kidney Injury. *Tuberous Sclerosis. *Ureteral Stones. *Vascular Disease ...

*  Central nervous system neoplasms synonyms, Central nervous system neoplasms antonyms -

Central nervous system disease in systemic lupus erythematosus. *Central nervous system diseases ... Central Nervous System Vasculitis. *central nervous systems. *central nervous systems. *central nervous systems ...

*  cyclophosphamide (Cytoxan) Cancer Drug Side Effects

Vasculitis. Vasculitis is a general term for a group of uncommon diseases which feature inflammation of the blood vessels. Each ... Lupus (Systemic Lupus Erythematosus or SLE). Systemic lupus erythematosus is a condition characterized by chronic inflammation ... Vasculitis. Vasculitis is a general term for a group of uncommon diseases which feature inflammation of the blood vessels. Each ... Systemic Lupus. Systemic lupus erythematosus is a condition characterized by chronic inflammation of body tissues caused by ...

Bullous small vessel vasculitis: Bullous small vessel vasculitis (also known as "Bullous variant of small vessel vasculitis") is a cutaneous condition in which patients with small vessel vasculitis will develop superimposed vesicles and bullae, especially on the distal extremities.Polyarteritis nodosaPulmonary-renal syndrome: Pulmonary-renal syndrome is a rare medical syndrome involving bleeding in the lungs and kidney damage (glomerulonephritis).Leukotriene receptor antagonist-associated Churg–Strauss syndromeStephen T. Wegener: Stephen Thomas Wegener (born November 20, 1952) is an American rehabilitation psychologist specializing in the psychology of pain management.Gillis, Linda (October 3, 1991).Retinal vasculitisKawasaki (surname): Kawasaki is a surname of Japanese origin (most commonly etc.) .Cutaneous small-vessel vasculitis: Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis," "Cutaneous leukocytoclastic vasculitis," "Cutaneous necrotizing venulitis," and "Hypersensitivity angiitis") is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura. It is the most common vasculitis seen in clinical practice.ImmunofluorescenceEpithelial basement membrane dystrophy: Epithelial basement membrane dystrophy (EBMD), also known as map-dot-fingerprint dystrophy and Cogans's microcystic dystrophy, is a disorder of the eye that can cause pain and dryness.Cryoglobulinemic vasculitis: Cryoglobulinemic vasculitis is a skin condition presenting in roughly 15% of people with a circulating cryoprecipitable protein.Autoantibody: An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases, (notably lupus erythematosus), are caused by such autoantibodies.Myeloperoxidase deficiency: Myeloperoxidase deficiency is an autosomal recessive genetic disorder featuring deficiency, either in quantity or of function, of myeloperoxidase, an enzyme found in certain phagocytic immune cells, especially polymorphonuclear leukocytes.Prolyl endopeptidase: Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the PREP gene.Lennox–Gastaut syndromeToroku arsenic disease: was a disease resulting from air and water pollution from a refinery at a mine at Toroku, located in Takachiho, Nishiusuki District, Miyazaki, Japan.Autoimmune diseaseGlomerulonephritisImmunosuppressive drug: Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:Giant-cell arteritisPrednisoloneNeutrophil granulocyteOtospondylomegaepiphyseal dysplasia: Otospondylomegaepiphyseal dysplasia (OSMED) is an autosomal recessive disorder of bone growth that results in skeletal abnormalities, severe hearing loss, and distinctive facial features. The name of the condition indicates that it affects hearing (oto-) and the bones of the spine (spondylo-), and enlarges the ends of bones (megaepiphyses).Cutis marmorata telangiectatica congenitaRheumatoid vasculitisMyelomonocyte: A myelomonocyte is a type of cell observed in chronic myelomonocytic leukemia. It bears a resemblance to both a myelocyte and monocyte.MethylprednisoloneEva Engvall: Eva Engvall, born 1940, is one of the scientists who invented ELISA in 1971.Eva Engvall, The Scientist 1995, 9(18):8CD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.Systemic lupus erythematosus and pregnancy: For women with systemic lupus erythematosus (SLE), pregnancy can present some particular challenges for both mother and child.Respiratory burst: Respiratory burst (sometimes called oxidative burst) is the rapid release of reactive oxygen species (superoxide radical and hydrogen peroxide) from different types of cells.ACR score for rheumatoid arthritis: ACR score is a scale to measure change in rheumatoid arthritis symptoms. It is named after the American College of Rheumatology.Monoclonal antibody therapyBiomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Endothelial activation: Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.Combination therapy: Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). Typically, these terms refer to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression).G-CSF factor stem-loop destabilising elementKidney: The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates. They remove excess organic molecules from the blood, and it is by this action that their best-known function is performed: the removal of waste products of metabolism.Protoplasm: Protoplasm is the living content of a cell that is surrounded by a plasma membrane. It is a general term for the cytoplasm.Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Gene polymorphismHaemophilus influenzae biogroup aegyptius: Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly known as pink eye. It was discovered independently by Koch and Weeks in the 1880s.

(1/26) Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa.


(2/26) Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?


(3/26) Rituximab may form a complex with IgMkappa mixed cryoglobulin and induce severe systemic reactions in patients with hepatitis C virus-induced vasculitis.


(4/26) Genetic factors associated with rheumatoid arthritis and systemic vasculitis: Evaluation of a panel of polymorphisms.


(5/26) An approach to the diagnosis and management of systemic vasculitis.


(6/26) Endothelial injury and repair in systemic vasculitis of the young.


(7/26) Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma.


(8/26) Treatment of primary systemic vasculitis with the inosine monophosphate dehydrogenase inhibitor mycophenolic acid.



  • de Groot K, Jayne D. What is new in the therapy of ANCA-associated vasculitides? (
  • take home messages from the 12th workshop on ANCA and systemic vasculitides. (
  • HSP nephritis and pulmonary findings may be confused with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. (
  • Unlike some other vasculitides (eg, microscopic polyarteritis, granulomatosis with polyangiitis [Wegener's]), polyarteritis nodosa is not associated with antineutrophil cytoplasmic antibodies (ANCA) [ 3 ]. (
  • Most importantly, the establishment and acceptance of microscopic polyangiitis as a distinct disease, and the routine availability and recognition of ANCA testing as critical to diagnosing vasculitides other than PAN, have led to more patients with vasculitis being classified as not having PAN. (
  • Microscopic polyangiitis and other ANCA-associated systemic vasculitides (eg, granulomatosis with polyangiitis [Wegener's] and eosinophilic granulomatosis with polyangiitis [Churg-Strauss]) that characteristically affect small vessels such as arterioles, capillaries, and venules, as well as muscular arteries, are discussed separately. (
  • Antineutrophil cytoplasmic autoantibodies (ANCA) are associated with vasculitis and glomerulonephritis. (


associated with antineutrophil

  • A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. (

medium sized muscular arteries

  • Polyarteritis nodosa is a form of necrotizing vasculitis of the small and medium sized muscular arteries, renal arteries and visceral arteries which may spread to surrounding veins. (
  • Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis that typically affects medium-sized muscular arteries, with occasional involvement of small muscular arteries [ 1,2 ]. (


  • The antineutrophil cytoplasmic antibody-associated vasculitides. (
  • Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. (
  • Should rituximab be used to treat antineutrophil cytoplasmic antibody associated vasculitis? (
  • See 'Overview of and approach to the vasculitides in adults' and 'Clinical spectrum of antineutrophil cytoplasmic autoantibodies' . (
  • No sinusitis, other localized infection, or systemic disease was identified by physical examination, imaging, or laboratory studies (negative blood cultures and antineutrophil cytoplasmic antibodies). (

polyarteritis nodosa

  • Cutaneous polyarteritis nodosa is the variant of polyarteritis nodosa which produce symptomatic skin vasculitis symptoms and signs. (



  • Patient cohorts of PAN included in case series and other research studies published prior to the 1990s almost certainly included a mixture of the newer definition of PAN with microscopic polyangiitis and possibly other forms of vasculitis. (


  • Because studies of the conjunctival microvasculature have provided sensitive indicators of both systemic and CNS vascular diseases we herein present the feasibility and applicability in diagnostic imaging of conjunctival blood flow (BF) velocity in patients with retinal vasculitis using a commercially available Retinal Function Imager (RFI, Optical Imaging Ltd, Rehovot, Israel). (
  • With the RFI we could demonstrate for the first time, that in patients with reduced retinal BF velocity due to retinal vasculitis also the conjunctival BF is significantly impaired and mirror the BF velocity changes of retinal microvasculature. (
  • Thus, imaging the conjunctival vasculature with the RFI could offer an easily to assess diagnostic tool in retinal vasculitis patients. (


  • Vasculitis is an inflammatory disease of blood vessels characterized by the alteration or destruction of the vessel wall. (


  • A 55 year s old woman, followed for diabetes and hypertension, presented to our consultation complaining of generalized pruritic lesions, without fever arthritis or any other systemic manifestations. (


  • Patients typically present with systemic symptoms. (


  • Histologically, the pseudotumor exhibited predominantly storiform-patterned fibrosis, dense plasma cell infiltrates, neutrophils, nuclear dust and angiocentric fibrosis (i.e., chronic localized fibrosing vasculitis), which coexisted with granular degeneration and mummification of collagen, stellate necrosis, and rare granulomas: diagnostic histologic features of limited orbital WG. (