Systemic Vasculitis: A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Polyarteritis Nodosa: A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.Antibodies, Antineutrophil Cytoplasmic: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.Churg-Strauss Syndrome: Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.Wegener Granulomatosis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.Myeloblastin: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.Arteritis: INFLAMMATION of any ARTERIES.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Cogan Syndrome: A condition consisting of inflammatory eye disease usually presenting as interstitial KERATITIS, vestibuloauditory dysfunction, and large- to medium-vessel vasculitis.Cryoglobulinemia: A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.Vasculitis, Central Nervous System: Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Otorhinolaryngologic Diseases: Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Giant Cell Arteritis: A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Rheumatoid Vasculitis: Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.Leukemia, Myelomonocytic, Chronic: A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Respiratory Burst: A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Purpura: Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

*  Systemic Vasculitis
Web-based systemic vasculitis learning tool for residents during rheumatology rotation and self-study for rheumatology health ... Vasculitis mimics. Curr Opin Rheumatol 2008;20:29-34.. * Langford CA. Chronic immunosuppressive therapy for systemic vasculitis ... Systemic vasculitis, as well as infection, malignancy, and vasculitis mimics, should be considered. ... Systemic vasculitis: consider ANCA-associated vasculitis (Wegener'sGranulomatosis (GPA), Microscopic Polyangiitis (MPA), Churg- ...
  https://www.rheumatology.org/Learning-Center/Educational-Activities/Rheum2Learn/Systemic-Vasculitis
*  Steroids and Methotrexate to Treat Systemic Vasculitis
... the safety and effectiveness of prednisone and methotrexate in treating severe Wegener's granulomatosis and other systemic vasc ... treatment of systemic vasculitis. Judgement of the ultimate value of such therapy should be. deferred until a greater number of ... An Open Trial of the Efficacy of Glucocorticoids and Methotrexate (MTX) in the Treatment of Systemic Vasculitis. Trial Phase:. ... Consequently, we have attempted to identify alternative therapies for the systemic. vasculitides that would be less toxic then ...
  http://www.knowcancer.com/cancer-trials/NCT00001256/
*  Systemic Vasculitides | Annals of Internal Medicine | American College of Physicians
Altered Peritoneal Permeability in Patients with Systemic Vasculitis Annals of Internal Medicine; 75 (5): 753-755 ... Clinical Course of Anti-Neutrophil Cytoplasmic Autoantibody-associated Glomerulonephritis and Systemic Vasculitis Annals of ... Vasculitis can appear in the differential diagnosis of virtually any type of organ failure; the murkier the picture, the more ... Paradoxically, the vasculitides seem to paralyze the clinician with regard to choosing diagnostic tests, determining the need ...
  http://annals.org/aim/article-abstract/705500/systemic-vasculitides
*  Central Manchester University Hospitals - NHS Foundation Trust - Primary systemic vasculitis
For primary systemic vasculitis the relevant immunological tests are Anti-Neutrophil cytoplasmic antibodies (ANCA), Anti- ... Primary systemic vasculitis This section deals with the clinical condition primary systemic vasculitis, listing the relevant ... Some forms of systemic vasculitis are strongly associated with circulating anti-neutrophil cytoplasmic antigens (ANCA). ...
  http://www.cmft.nhs.uk/info-for-health-professionals/laboratory-medicine/immunology/clinical-conditions-covered-by-immunology/vasculitis/primary-systemic-vasculitis
*  Development of comprehensive disease assessment in systemic vasculitis | Annals of the Rheumatic Diseases
The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the ... 6Vasculitis Center, Johns Hopkins University, Baltimore, Maryland, USA. *. 7Department of Nephrology, University of Malmo, ... and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis ... A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and ...
  http://ard.bmj.com/content/66/3/283
*  Angiotropic large cell lymphoma with mononeuritis multiplex mimicking systemic vasculitis. | Journal of Neurology, Neurosurgery...
The clinical diagnosis was a systemic necrotising vasculitis and it is considered that its differential diagnosis must include ...
  http://jnnp.bmj.com/content/58/3/363
*  American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for...
Vasculitis. Arteritis. Systemic Vasculitis. Granulomatosis with Polyangiitis. Microscopic Polyangiitis. Takayasu Arteritis. ... Patients with primary systemic vasculitis or a mimic of these diseases seen in participating secondary or tertiary care centres ... Nomenclature of systemic vasculitides. Proposal of an international consensus conference. Arthritis Rheum. 1994 Feb;37(2):187- ... One of the aims of this project is to develop diagnostic criteria for the primary systemic vasculitides (granulomatosis with ...
  https://clinicaltrials.gov/ct2/show/NCT01066208?recr=Open&cond=%22Polymyalgia+Rheumatica%22&rank=13
*  New Features of Disease After Diagnosis in 6 Forms of Systemic Vasculitis | The Journal of Rheumatology
New Features of Disease After Diagnosis in 6 Forms of Systemic Vasculitis. Peter C. Grayson, David Cuthbertson, Simon Carette, ... New Features of Disease After Diagnosis in 6 Forms of Systemic Vasculitis ... New Features of Disease After Diagnosis in 6 Forms of Systemic Vasculitis ... New Features of Disease After Diagnosis in 6 Forms of Systemic Vasculitis ...
  http://www.jrheum.org/content/early/2013/07/23/jrheum.121473
*  The kidney in systemic vasculitis : Oxford Textbook of Medicine - oi
Systemic vasculitis can occur as a primary autoimmune disorder, or as a secondary manifestation of another disease process (e.g ... Systemic vasculitis can occur as a primary autoimmune disorder, or as a secondary manifestation of another disease process (e.g ... Primary systemic vasculitis is classified according to the predominant size of blood vessel involved and the presence of ... Primary systemic vasculitis is classified according to the predominant size of blood vessel involved and the presence of ...
  http://oxfordindex.oup.com/view/10.1093/med/9780199204854.003.211002_update_001
*  Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases | Annals of...
Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases ... Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases ... EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis. Ann Rheum Dis 2016;75:1583-94. doi:10.1136/ ... In the recent series of 284 patients with ANCA-associated vasculitides, we have detected ANCAs by this approach in 96.9% of ...
  http://ard.bmj.com/content/76/8/e23
*  Myocarditis suggesting acute myocardial ischemia, without occlusion of the coronary artery, in a patient with antiphospholipid...
... systemic vasculitis and chronic anaemia in the course of cold agglutinin disease, resolved meningitis, mediastinal ... in a patient with antiphospholipid syndrome and systemic vasculitis in the course of cold agglutinin disease. Andrzej J. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5421523/
*  Hypertension in Systemic Necrotizing Vasculitis | Annals of Internal Medicine | American College of Physicians
Hypertension in Systemic Necrotizing Vasculitis J. L. LEJONC, M.D.; I. MACQUIN, M.D.; P. BROCHARD, M.D.; A. SCHAEFFER, M.D. ... LEJONC JL, MACQUIN I, BROCHARD P, SCHAEFFER A. Hypertension in Systemic Necrotizing Vasculitis. Ann Intern Med. 1980;93:150. ... Hypertension, Hyperreninemia, and Secondary Hyperaldosteronism in Systemic Necrotizing Vasculitis Annals of Internal Medicine; ... reported in the February 1980 issue two cases of hypertension with hyperreninemia complicating systemic necrotizing vasculitis ...
  http://annals.org/aim/article-abstract/694188/hypertension-systemic-necrotizing-vasculitis
*  Systemic Vasculitides PDF - Am-Medicine
Systemic Vasculitides PDF For Free. This Website we Provide Free Medical Books for all Students ... Meta Keywords: Systemic Vasculitides PDF, Systemic Vasculitides PDF Free Download, Systemic Vasculitides PDF Ebook, free ... In spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical ... This explosion of knowledge is obviously resulting in state-of-the-art, personalized treatments of systemic vasculitides. ...
  http://am-medicine.com/2017/01/systemic-vasculitides-current-status-and-perspectives.html
*  Disease assessment in systemic vasculitis. - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences
... remission and response to therapy for patients with systemic vasculitis. Clinical assessment remains the current gold standard ... a rational basis for clinical management as well as being essential in the conduct of clinical trials and studies in vasculitis ... The anti-neutrophil cytoplasm antibody-associated vasculitides are complex multi-system disorders with many overlapping ... remission and response to therapy for patients with systemic vasculitis. Clinical assessment remains the current gold standard ...
  https://www.ndorms.ox.ac.uk/publications/506978
*  Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. - Oxford Neuroscience
We describe humanised monoclonal antibody therapy in four patients with severe systemic vasculitis unresponsive to ... Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. Lockwood CM., Thiru S., Isaacs JD., ... We describe humanised monoclonal antibody therapy in four patients with severe systemic vasculitis unresponsive to ...
  https://www.neuroscience.ox.ac.uk/publications/12604
*  Assessing disease activity in the systemic vasculitides. - Nuffield Department of Orthopaedics, Rheumatology and...
Assessment of systemic vasculitis is an essential part of its management. Better understanding of the underlying ... that can assist in the treatment of individual patients and play an important role in clinical trials of systemic vasculitis. ... The improvement in survival of the systemic vasculitides with the use of current immunosuppression has heightened awareness of ... pathophysiology of the antineutrophil cytoplasmic antibody-related vasculitides has resulted in improved assays and may result ...
  https://www.ndorms.ox.ac.uk/publications/108569
*  AB0577 Systemic autoimmune vasculitis in rheumatoid arthritis - a postmortem clinicopathologic study of 161 patients | Annals...
Background Systemic vasculitis of autoimmune origin (A-SV) may be regarded as a basic histological manifestation of rheumatoid ... Objectives The aim of this study was to characterize the severity of systemic autoimmune vasculitis at death in RA patients. ... AB0577 Systemic autoimmune vasculitis in rheumatoid arthritis - a postmortem clinicopathologic study of 161 patients ... AB0577 Systemic autoimmune vasculitis in rheumatoid arthritis - a postmortem clinicopathologic study of 161 patients ...
  http://ard.bmj.com/content/76/Suppl_2/1252.3
*  STANDARIZATION OF DISEASE ASSESMENT IN SYSTEMIC VASCULITIS: USE OF A NOVEL WEB-BASED SOFTWARE TRAINING APPLICATION - Nuffield...
STANDARIZATION OF DISEASE ASSESMENT IN SYSTEMIC VASCULITIS: USE OF A NOVEL WEB-BASED SOFTWARE TRAINING APPLICATION Share Share ... STANDARIZATION OF DISEASE ASSESMENT IN SYSTEMIC VASCULITIS: USE OF A NOVEL WEB-BASED SOFTWARE TRAINING APPLICATION ...
  https://www.ndorms.ox.ac.uk/publications/579399
*  Development of comprehensive disease assessment in systemic vasculitis. - Nuffield Department of Orthopaedics, Rheumatology and...
... and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis ... A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and ... The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic ... The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the ...
  https://www.ndorms.ox.ac.uk/publications/108426
*  Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune...
Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis ... Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune ... Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune ... Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune ...
  http://discovery.ucl.ac.uk/1337582/
*  The role of biologic therapies in the management of systemic vasculitis. - Nuffield Department of Orthopaedics, Rheumatology...
While the advent of biologics heralds a new era in the management of the systemic vasculitis, evidence for their efficacy is ... In this review, we examine the up-to-date evidence for the use of biologics in systemic vasculitis, including TNF-alpha ... of the pathogenesis of vascular inflammation has led to their application in the treatment of primary systemic vasculitis. ... We examine the rationale for using biologics based on the pathophysiology of vasculitis. Issues of toxicity and ...
  https://www.ndorms.ox.ac.uk/publications/108897
*  Bilateral multiple choroidal granulomas and systemic vasculitis as presenting features of tuberculosis in an immunocompetent...
The features of systemic vasculitis and biopsy proven nodular lesions on palms which resolved with ATT also indicated ... A 26-year-old male Indian patient presented with bilateral blurred vision and systemic illness with vasculitis-like features. ... 4). A possible diagnosis of systemic vasculitis or infective endocarditis was also considered. Radiology of the spine revealed ... Blood investigations to rule out systemic vasculitis (antinuclear antibodies, RA factor, c-ANCA, and p-ANCA) and other ...
  https://joii-journal.springeropen.com/articles/10.1186/s12348-016-0109-9
*  Factors Associated with Major Cardiovascular Events in Patients with Systemic Necrotizing Vasculitides: Results of a Longterm...
Objective. Systemic necrotizing vasculitides (SNV) are associated with more frequent subclinical atherosclerosis, suggesting ... Factors Associated with Major Cardiovascular Events in Patients with Systemic Necrotizing Vasculitides: Results of a Longterm ... Factors Associated with Major Cardiovascular Events in Patients with Systemic Necrotizing Vasculitides: Results of a Longterm ... Factors Associated with Major Cardiovascular Events in Patients with Systemic Necrotizing Vasculitides: Results of a Longterm ...
  http://www.jrheum.org/content/41/4/723
*  en fr An Exploration of Non-Antineutrophil Cytoplasmic Antibodies Serum Biomarkers in Systemic Vasculitis : An Investigation of...
en fr An Exploration of Non-Antineutrophil Cytoplasmic Antibodies Serum Biomarkers in Systemic Vasculitis : An Investigation of ... en fr An Exploration of Non-Antineutrophil Cytoplasmic Antibodies Serum Biomarkers in Systemic Vasculitis : An Investigation of ... en fr An Exploration of Non-Antineutrophil Cytoplasmic Antibodies Serum Biomarkers in Systemic Vasculitis : An Investigation of ... a non-antineutrophil cytoplasmic antibodies ANCA inflammatory vasculitis, are numerous. This study offers an exhaustive review ...
  http://libros.duhnnae.com/2017/jul7/150083543532-en-fr-An-Exploration-of-Non-Antineutrophil-Cytoplasmic-Antibodies-Serum-Biomarkers-in-Systemic-Vasculitis-An-Investigation-of-Behcets-Disease-Un.php
*  Source Naturals :: Potassium Iodide
... have dermatitis herpetiformis or hypocomplementemic vasculitis, or have nodular thyroid disease with heart disease. If you are ... Systemic Enzymes Vitamins & Multiples Weight Management Winter Season Support Women's Health Products ...
  http://www.sourcenaturals.com/products/GP1699/

Bullous small vessel vasculitis: Bullous small vessel vasculitis (also known as "Bullous variant of small vessel vasculitis") is a cutaneous condition in which patients with small vessel vasculitis will develop superimposed vesicles and bullae, especially on the distal extremities.Polyarteritis nodosaPulmonary-renal syndrome: Pulmonary-renal syndrome is a rare medical syndrome involving bleeding in the lungs and kidney damage (glomerulonephritis).Leukotriene receptor antagonist-associated Churg–Strauss syndromeStephen T. Wegener: Stephen Thomas Wegener (born November 20, 1952) is an American rehabilitation psychologist specializing in the psychology of pain management.Gillis, Linda (October 3, 1991).Retinal vasculitisKawasaki (surname): Kawasaki is a surname of Japanese origin (most commonly etc.) .Cutaneous small-vessel vasculitis: Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis," "Cutaneous leukocytoclastic vasculitis," "Cutaneous necrotizing venulitis," and "Hypersensitivity angiitis") is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura. It is the most common vasculitis seen in clinical practice.ImmunofluorescenceEpithelial basement membrane dystrophy: Epithelial basement membrane dystrophy (EBMD), also known as map-dot-fingerprint dystrophy and Cogans's microcystic dystrophy, is a disorder of the eye that can cause pain and dryness.Cryoglobulinemic vasculitis: Cryoglobulinemic vasculitis is a skin condition presenting in roughly 15% of people with a circulating cryoprecipitable protein.Autoantibody: An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases, (notably lupus erythematosus), are caused by such autoantibodies.Myeloperoxidase deficiency: Myeloperoxidase deficiency is an autosomal recessive genetic disorder featuring deficiency, either in quantity or of function, of myeloperoxidase, an enzyme found in certain phagocytic immune cells, especially polymorphonuclear leukocytes.Prolyl endopeptidase: Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the PREP gene.Lennox–Gastaut syndromeToroku arsenic disease: was a disease resulting from air and water pollution from a refinery at a mine at Toroku, located in Takachiho, Nishiusuki District, Miyazaki, Japan.Autoimmune diseaseGlomerulonephritisImmunosuppressive drug: Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:Giant-cell arteritisPrednisoloneNeutrophil granulocyteOtospondylomegaepiphyseal dysplasia: Otospondylomegaepiphyseal dysplasia (OSMED) is an autosomal recessive disorder of bone growth that results in skeletal abnormalities, severe hearing loss, and distinctive facial features. The name of the condition indicates that it affects hearing (oto-) and the bones of the spine (spondylo-), and enlarges the ends of bones (megaepiphyses).Cutis marmorata telangiectatica congenitaRheumatoid vasculitisMyelomonocyte: A myelomonocyte is a type of cell observed in chronic myelomonocytic leukemia. It bears a resemblance to both a myelocyte and monocyte.MethylprednisoloneEva Engvall: Eva Engvall, born 1940, is one of the scientists who invented ELISA in 1971.Eva Engvall, The Scientist 1995, 9(18):8CD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.Systemic lupus erythematosus and pregnancy: For women with systemic lupus erythematosus (SLE), pregnancy can present some particular challenges for both mother and child.Respiratory burst: Respiratory burst (sometimes called oxidative burst) is the rapid release of reactive oxygen species (superoxide radical and hydrogen peroxide) from different types of cells.ACR score for rheumatoid arthritis: ACR score is a scale to measure change in rheumatoid arthritis symptoms. It is named after the American College of Rheumatology.Monoclonal antibody therapyBiomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Endothelial activation: Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.Combination therapy: Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). Typically, these terms refer to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression).G-CSF factor stem-loop destabilising elementKidney: The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates. They remove excess organic molecules from the blood, and it is by this action that their best-known function is performed: the removal of waste products of metabolism.Protoplasm: Protoplasm is the living content of a cell that is surrounded by a plasma membrane. It is a general term for the cytoplasm.Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Gene polymorphismHaemophilus influenzae biogroup aegyptius: Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly known as pink eye. It was discovered independently by Koch and Weeks in the 1880s.

(1/26) Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa.

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(2/26) Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?

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(3/26) Rituximab may form a complex with IgMkappa mixed cryoglobulin and induce severe systemic reactions in patients with hepatitis C virus-induced vasculitis.

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(4/26) Genetic factors associated with rheumatoid arthritis and systemic vasculitis: Evaluation of a panel of polymorphisms.

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(5/26) An approach to the diagnosis and management of systemic vasculitis.

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(6/26) Endothelial injury and repair in systemic vasculitis of the young.

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(7/26) Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma.

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(8/26) Treatment of primary systemic vasculitis with the inosine monophosphate dehydrogenase inhibitor mycophenolic acid.

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