Systemic Vasculitis: A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Polyarteritis Nodosa: A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.Antibodies, Antineutrophil Cytoplasmic: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.Churg-Strauss Syndrome: Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.Wegener Granulomatosis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.Myeloblastin: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.Arteritis: INFLAMMATION of any ARTERIES.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Cogan Syndrome: A condition consisting of inflammatory eye disease usually presenting as interstitial KERATITIS, vestibuloauditory dysfunction, and large- to medium-vessel vasculitis.Cryoglobulinemia: A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.Vasculitis, Central Nervous System: Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Otorhinolaryngologic Diseases: Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Giant Cell Arteritis: A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Rheumatoid Vasculitis: Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.Leukemia, Myelomonocytic, Chronic: A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Respiratory Burst: A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Purpura: Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

*  Systemic Vasculitis

Web-based systemic vasculitis learning tool for residents during rheumatology rotation and self-study for rheumatology health ... Vasculitis mimics. Curr Opin Rheumatol 2008;20:29-34.. * Langford CA. Chronic immunosuppressive therapy for systemic vasculitis ... Systemic vasculitis, as well as infection, malignancy, and vasculitis mimics, should be considered. ... Systemic vasculitis: consider ANCA-associated vasculitis (Wegener'sGranulomatosis (GPA), Microscopic Polyangiitis (MPA), Churg- ...

*  Systemic Vasculitides | Annals of Internal Medicine | American College of Physicians

Altered Peritoneal Permeability in Patients with Systemic Vasculitis Annals of Internal Medicine; 75 (5): 753-755 ... Clinical Course of Anti-Neutrophil Cytoplasmic Autoantibody-associated Glomerulonephritis and Systemic Vasculitis Annals of ... Vasculitis can appear in the differential diagnosis of virtually any type of organ failure; the murkier the picture, the more ... Paradoxically, the vasculitides seem to paralyze the clinician with regard to choosing diagnostic tests, determining the need ...

*  Central Manchester University Hospitals - NHS Foundation Trust - Primary systemic vasculitis

For primary systemic vasculitis the relevant immunological tests are Anti-Neutrophil cytoplasmic antibodies (ANCA), Anti- ... Primary systemic vasculitis This section deals with the clinical condition primary systemic vasculitis, listing the relevant ... Some forms of systemic vasculitis are strongly associated with circulating anti-neutrophil cytoplasmic antigens (ANCA). ...

*  Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases | Annals of...

Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases ... Testing for antineutrophil cytoplasmic antibodies (ANCAs) in patients with systemic vasculitides and other diseases ... EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis. Ann Rheum Dis 2016;75:1583-94. doi:10.1136/ ... In the recent series of 284 patients with ANCA-associated vasculitides, we have detected ANCAs by this approach in 96.9% of ...

*  Myocarditis suggesting acute myocardial ischemia, without occlusion of the coronary artery, in a patient with antiphospholipid...

... systemic vasculitis and chronic anaemia in the course of cold agglutinin disease, resolved meningitis, mediastinal ... in a patient with antiphospholipid syndrome and systemic vasculitis in the course of cold agglutinin disease. Andrzej J. ...

*  Hypertension in Systemic Necrotizing Vasculitis | Annals of Internal Medicine | American College of Physicians

Hypertension in Systemic Necrotizing Vasculitis J. L. LEJONC, M.D.; I. MACQUIN, M.D.; P. BROCHARD, M.D.; A. SCHAEFFER, M.D. ... LEJONC JL, MACQUIN I, BROCHARD P, SCHAEFFER A. Hypertension in Systemic Necrotizing Vasculitis. Ann Intern Med. 1980;93:150. ... Hypertension, Hyperreninemia, and Secondary Hyperaldosteronism in Systemic Necrotizing Vasculitis Annals of Internal Medicine; ... reported in the February 1980 issue two cases of hypertension with hyperreninemia complicating systemic necrotizing vasculitis ...

*  Disease assessment in systemic vasculitis. - Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences

... remission and response to therapy for patients with systemic vasculitis. Clinical assessment remains the current gold standard ... a rational basis for clinical management as well as being essential in the conduct of clinical trials and studies in vasculitis ... The anti-neutrophil cytoplasm antibody-associated vasculitides are complex multi-system disorders with many overlapping ... remission and response to therapy for patients with systemic vasculitis. Clinical assessment remains the current gold standard ...

*  Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. - Oxford Neuroscience

We describe humanised monoclonal antibody therapy in four patients with severe systemic vasculitis unresponsive to ... Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. Lockwood CM., Thiru S., Isaacs JD., ... We describe humanised monoclonal antibody therapy in four patients with severe systemic vasculitis unresponsive to ...

*  Development of comprehensive disease assessment in systemic vasculitis. - Nuffield Department of Orthopaedics, Rheumatology and...

... and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis ... A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and ... The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic ... The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the ...

*  Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune...

Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis ... Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune ... Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune ... Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune ...

*  The role of biologic therapies in the management of systemic vasculitis. - Nuffield Department of Orthopaedics, Rheumatology...

While the advent of biologics heralds a new era in the management of the systemic vasculitis, evidence for their efficacy is ... In this review, we examine the up-to-date evidence for the use of biologics in systemic vasculitis, including TNF-alpha ... of the pathogenesis of vascular inflammation has led to their application in the treatment of primary systemic vasculitis. ... We examine the rationale for using biologics based on the pathophysiology of vasculitis. Issues of toxicity and ...

*  Bilateral multiple choroidal granulomas and systemic vasculitis as presenting features of tuberculosis in an immunocompetent...

The features of systemic vasculitis and biopsy proven nodular lesions on palms which resolved with ATT also indicated ... A 26-year-old male Indian patient presented with bilateral blurred vision and systemic illness with vasculitis-like features. ... 4). A possible diagnosis of systemic vasculitis or infective endocarditis was also considered. Radiology of the spine revealed ... Blood investigations to rule out systemic vasculitis (antinuclear antibodies, RA factor, c-ANCA, and p-ANCA) and other ...

*  EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. - Nuffield...

... and provide contemporary points to consider for the development of future definitions and criteria in systemic vasculitis. ... CONCLUSIONS: Limitations in current classification criteria and definitions for vasculitis have been identified and suggestions ... these should form the basis of future attempts to develop and validate revised criteria and definitions of vasculitis. ... The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can significantly improve outcomes. ...

*  A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis. - Nuffield Department of...

... in a cohort of patients with systemic vasculitis. METHODS: A total of 238 patients with vasculitis from seven countries in ... This study increases the utility of the BVAS v. 3 in different populations of patients with systemic vasculitis. ... CONCLUSION: The BVAS v. 3 has been evaluated in a large cohort of patients with vasculitis and the important properties of the ... Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's ...

*  Update on the use of biologics in primary systemic vasculitides. - Nuffield Department of Orthopaedics, Rheumatology and...

In this review, we examine the rationale for using biologics based on the pathophysiology of primary systemic vasculitis. The ... evidence for the standard of care of patients with vasculitis and the role of biologic therapy in primary systemic vasculitis. ... mediated inflammatory diseases has led to the application of biologic therapies in the treatment of primary systemic vasculitis ... Update on the use of biologics in primary systemic vasculitides. Share Share Share Share ...

*  BMJ Best Practice

Commonly, however, vasculitis refers to the systemic vasculitides, which are autoimmune disorders characterised by inflammation ... The systemic vasculitides are a diverse group of disorders that demonstrate a wide range of organ involvement and clinical ... The systemic vasculitides are sub-acute illnesses associated with signs and symptoms of chronic inflammation. ... Vasculitis can affect virtually any organ system; many of these diseases have typical patterns of involvement that are ...

*  OpenAIRE - Person

Primary Systemic Vasculitis in Childhood. Pereira, N.; Amaro, C (2012). As vasculites sistémicas constituem um grupo de doenças ...

*  User:Djd/sandbox/MedNav/Pathology templates - Wikipedia

Systemic vasculitis}}. Medicine. Vasculitis/arteritis: systemic vasculitis (M30-M31, 446). Disease and disorder templates. ... Systemic connective tissue disorders}}. Medicine. Systemic Connective tissue disorders (M32-M36, 710). Disease and disorder ... Viral systemic diseases}}. Medicine. Infectious diseases - Viral systemic diseases (A80-B34, 042-079). Infectious disease ... Cutaneous vasculitis}}. Medicine. Cutaneous vasculitis and other vascular-related cutaneous conditions (L95, 709.1). ...

*  Dr. Jai Radhakrishnan, MD - New York, NY - Nephrology | Healthgrades.com

Visit Healthgrades for information on Dr. Jai Radhakrishnan, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.

*  Dr. Arshia Ghaffari, MD - Los Angeles, CA - Nephrology | Healthgrades.com

Visit Healthgrades for information on Dr. Arshia Ghaffari, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.

*  Dr. Dana Miskulin, MD - Boston, MA - Nephrology | Healthgrades.com

Systemic Vasculitis. *Traumatic Acute Kidney Injury. *Ureteral Stones. *Vascular Disease. *Vitamin D Deficiency ...

*  Dr. Hom Neupane, MD - Syracuse, NY - Rheumatology & Internal Medicine | Healthgrades.com

Systemic Vasculitis. *Takayasu's Arteritis. *Temporal Arteritis. *Trigger Finger. *Vascular Disease. *Vasculitis. *Wegener's ...

*  Eric Windsor, DAC - Ellicott City, MD - Acupuncture | Healthgrades.com

Systemic Vasculitis. *TMJ. *Tension Headache. *Thyroid Cancer. *Torticollis. *Traumatic Brain Injury. *Traumatic Injuries ...

*  Dr. Salam Gharaybeh, MD - Victoria, TX - Pediatric Nephrology & Nephrology & Pediatrics | Healthgrades.com

Systemic Vasculitis. *Traumatic Acute Kidney Injury. *Tuberous Sclerosis. *Ureteral Stones. *Vascular Disease ...

*  Rheumatology | Columbia Asia India

Treatment for psoriatic arthritis, vasculitis, systemic lupus erythematosus and scleroderma. *Management of gout and pseudogout ... Other diseases managed are collagen vascular diseases like Systemic Lupus Erythematosus (SLE), Poly Arteritis Nodosa (PAN) and ...

Bullous small vessel vasculitis: Bullous small vessel vasculitis (also known as "Bullous variant of small vessel vasculitis") is a cutaneous condition in which patients with small vessel vasculitis will develop superimposed vesicles and bullae, especially on the distal extremities.Polyarteritis nodosaPulmonary-renal syndrome: Pulmonary-renal syndrome is a rare medical syndrome involving bleeding in the lungs and kidney damage (glomerulonephritis).Leukotriene receptor antagonist-associated Churg–Strauss syndromeStephen T. Wegener: Stephen Thomas Wegener (born November 20, 1952) is an American rehabilitation psychologist specializing in the psychology of pain management.Gillis, Linda (October 3, 1991).Retinal vasculitisKawasaki (surname): Kawasaki is a surname of Japanese origin (most commonly etc.) .Cutaneous small-vessel vasculitis: Cutaneous small-vessel vasculitis (also known as "Cutaneous leukocytoclastic angiitis," "Cutaneous leukocytoclastic vasculitis," "Cutaneous necrotizing venulitis," and "Hypersensitivity angiitis") is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura. It is the most common vasculitis seen in clinical practice.ImmunofluorescenceEpithelial basement membrane dystrophy: Epithelial basement membrane dystrophy (EBMD), also known as map-dot-fingerprint dystrophy and Cogans's microcystic dystrophy, is a disorder of the eye that can cause pain and dryness.Cryoglobulinemic vasculitis: Cryoglobulinemic vasculitis is a skin condition presenting in roughly 15% of people with a circulating cryoprecipitable protein.Autoantibody: An autoantibody is an antibody (a type of protein) produced by the immune system that is directed against one or more of the individual's own proteins. Many autoimmune diseases, (notably lupus erythematosus), are caused by such autoantibodies.Myeloperoxidase deficiency: Myeloperoxidase deficiency is an autosomal recessive genetic disorder featuring deficiency, either in quantity or of function, of myeloperoxidase, an enzyme found in certain phagocytic immune cells, especially polymorphonuclear leukocytes.Prolyl endopeptidase: Prolyl endopeptidase (PE) also known as prolyl oligopeptidase or post-proline cleaving enzyme is an enzyme that in humans is encoded by the PREP gene.Lennox–Gastaut syndromeToroku arsenic disease: was a disease resulting from air and water pollution from a refinery at a mine at Toroku, located in Takachiho, Nishiusuki District, Miyazaki, Japan.Autoimmune diseaseGlomerulonephritisImmunosuppressive drug: Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:Giant-cell arteritisPrednisoloneNeutrophil granulocyteOtospondylomegaepiphyseal dysplasia: Otospondylomegaepiphyseal dysplasia (OSMED) is an autosomal recessive disorder of bone growth that results in skeletal abnormalities, severe hearing loss, and distinctive facial features. The name of the condition indicates that it affects hearing (oto-) and the bones of the spine (spondylo-), and enlarges the ends of bones (megaepiphyses).Cutis marmorata telangiectatica congenitaRheumatoid vasculitisMyelomonocyte: A myelomonocyte is a type of cell observed in chronic myelomonocytic leukemia. It bears a resemblance to both a myelocyte and monocyte.MethylprednisoloneEva Engvall: Eva Engvall, born 1940, is one of the scientists who invented ELISA in 1971.Eva Engvall, The Scientist 1995, 9(18):8CD4 immunoadhesin: CD4 immunoadhesin is a recombinant fusion protein consisting of a combination of CD4 and the fragment crystallizable region.Systemic lupus erythematosus and pregnancy: For women with systemic lupus erythematosus (SLE), pregnancy can present some particular challenges for both mother and child.Respiratory burst: Respiratory burst (sometimes called oxidative burst) is the rapid release of reactive oxygen species (superoxide radical and hydrogen peroxide) from different types of cells.ACR score for rheumatoid arthritis: ACR score is a scale to measure change in rheumatoid arthritis symptoms. It is named after the American College of Rheumatology.Monoclonal antibody therapyBiomarkers of aging: Biomarkers of aging are biomarkers that better predict functional capacity at a later age than chronological age. Stated another way, biomarkers of aging would give the true "biological age", which may be different from the chronological age.Endothelial activation: Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others.Combination therapy: Combination therapy or polytherapy is therapy that uses more than one medication or modality (versus monotherapy, which is any therapy taken alone). Typically, these terms refer to using multiple therapies to treat a single disease, and often all the therapies are pharmaceutical (although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression).G-CSF factor stem-loop destabilising elementKidney: The kidneys are bean-shaped organs that serve several essential regulatory roles in vertebrates. They remove excess organic molecules from the blood, and it is by this action that their best-known function is performed: the removal of waste products of metabolism.Protoplasm: Protoplasm is the living content of a cell that is surrounded by a plasma membrane. It is a general term for the cytoplasm.Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Gene polymorphismHaemophilus influenzae biogroup aegyptius: Haemophilus influenzae biogroup aegyptius (Hae) is a causative agent of acute and often purulent conjunctivitis, more commonly known as pink eye. It was discovered independently by Koch and Weeks in the 1880s.

(1/26) Incidence and survival rates in Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and polyarteritis nodosa.

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(2/26) Value of anti-infective chemoprophylaxis in primary systemic vasculitis: what is the evidence?

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(3/26) Rituximab may form a complex with IgMkappa mixed cryoglobulin and induce severe systemic reactions in patients with hepatitis C virus-induced vasculitis.

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(4/26) Genetic factors associated with rheumatoid arthritis and systemic vasculitis: Evaluation of a panel of polymorphisms.

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(5/26) An approach to the diagnosis and management of systemic vasculitis.

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(6/26) Endothelial injury and repair in systemic vasculitis of the young.

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(7/26) Systemic vasculopathy with altered vasoreactivity in a transgenic mouse model of scleroderma.

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(8/26) Treatment of primary systemic vasculitis with the inosine monophosphate dehydrogenase inhibitor mycophenolic acid.

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Lupus Erythematosus

  • Systemic lupus erythematosus - a connective tissue disorder involving mainly the skin, joints and kidneys. (wikipedia.org)
  • Mathieson's major clinical interest is in autoimmune renal diseases, such as glomerulonephritis, systemic vasculitis, systemic lupus erythematosus. (wikipedia.org)
  • Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others. (wikipedia.org)
  • Autoimmune diseases and vasculitis: systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel disease. (wikipedia.org)

blood vessels

  • Commonly, however, vasculitis refers to the systemic vasculitides, which are autoimmune disorders characterised by inflammation of blood vessels. (bmj.com)
  • There is irregular fibrosis of the blood vessels due to chronic vasculitis, leading to sometimes massive intimal fibrosis (fibrosis of the inner section of the blood vessels). (wikipedia.org)
  • It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs. (wikipedia.org)
  • Granulomatosis with polyangiitis is part of a larger group of vasculitic syndromes called systemic vasculitides or necrotizing vasculopathies, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ANCAs (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels. (wikipedia.org)
  • Vasculitis is a group of disorders that destroy blood vessels by inflammation. (wikipedia.org)
  • For example, ICD-10 classifies "vasculitis limited to skin" with skin conditions (under "L"), and "necrotizing vasculopathies" (corresponding to systemic vasculitis) with musculoskeletal system and connective tissue conditions (under "M"). Arteritis/phlebitis on their own are classified with circulatory conditions (under "I"). Type or size of the blood vessels that they predominantly affect. (wikipedia.org)
  • also known as Churg-Strauss syndrome [CSS] or allergic granulomatosis) is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels (vasculitis) in persons with a history of airway allergic hypersensitivity (atopy). (wikipedia.org)

primary systemic vasculitides

  • Update on the use of biologics in primary systemic vasculitides. (ox.ac.uk)
  • When using the influential classification known as the "Chapel Hill Consensus Conference", the terms "systemic vasculitis" or "primary systemic vasculitides" are commonly used. (wikipedia.org)

inflammation

  • The steady increase in use of biologic agents coupled with the expansion in the knowledge of the pathogenesis of vascular inflammation has led to their application in the treatment of primary systemic vasculitis. (ox.ac.uk)
  • The systemic vasculitides are sub-acute illnesses associated with signs and symptoms of chronic inflammation. (bmj.com)
  • In its strictest sense, the term vasculitis denotes inflammation of a blood vessel, which is characterised by the presence of an inflammatory infiltrate and destruction of the vessel wall. (bmj.com)
  • On histopathological examination, a biopsy will show leukocytoclastic vasculitis with necrotic changes and granulomatous inflammation (clumps of typically arranged white blood cells) on microscopy. (wikipedia.org)
  • At least 3 out of 5 criteria yields sensitivity and specificity of 95 and 91%: Age at onset ≥ 50 years New onset headache with localized tenderness Temporal artery tenderness or decreased pulsation Elevated ESR ≥ 50 mm/hour Westergren Temporal artery biopsy showing vasculitis with mononuclear cell infiltrate or granulomatous inflammation, usually with multinucleated giant cells These conditions are sometimes considered together with the small vessel vasculitides. (wikipedia.org)
  • Biopsy of these lesions reveal inflammation of the small vessels, termed leukocytoclastic vasculitis, which is most prominent in postcapillary venules. (wikipedia.org)
  • Although both occur in vasculitis, inflammation of veins (phlebitis) or arteries (arteritis) are their own are separate entities. (wikipedia.org)
  • In pediatric patients varicella inflammation may be followed by vasculitis of intracranial vessels. (wikipedia.org)
  • Disease Disseminated disease Fred Siguier List of systemic diseases with ocular manifestations Localized disease Marfan syndrome Systemic autoimmune diseases Systemic inflammation Dorland's Illustrated Medical Dictionary,28th edition (Harcourt Brace & Company). (wikipedia.org)
  • Relapsing polychondritis is a multi-systemic condition characterized by repeated episodes of inflammation and deterioration of cartilage. (wikipedia.org)

ANCA

  • Some forms of systemic vasculitis are strongly associated with circulating anti-neutrophil cytoplasmic antigens (ANCA). (cmft.nhs.uk)
  • In the recent series of 284 patients with ANCA-associated vasculitides, we have detected ANCAs by this approach in 96.9% of patients with microscopic polyangiitis (MPA) but only in 72.7% of patients with granulomatosis with polyangiitis (GPA) ( table 1 ). (bmj.com)
  • ANCA testing should be performed only in the clinical context since PR3-ANCA and MPO-ANCA can be found in the other conditions than vasculitis, for example, infective endocarditis, 3 tuberculosis, 4 primary sclerosing cholangitis 5 and interstitial lung diseases. (bmj.com)
  • Damoiseaux et al suggested that ANCA-associated vasculitides may be classified based on the ANCA serotype since recent studies have shown that PR3-ANCA and MPO-ANCA diseases are strongly associated with distinguishable genetic alleles, phenotypic differences and differences in risk of relapse and response to immunosuppressive treatment. (bmj.com)
  • However, not all studies confirm a predictive value of ANCA specificity in patients with ANCA-associated vasculitis. (bmj.com)
  • Miloslavsky et al 8 in a pooled analysis of the Wegener's Granulomatosis Etanercept Trial and the Rituximab in Associated Vasculitis (ANCA) (RAVE) trial were unable to demonstrate the important clinical differences between patients who were MPO-ANCA positive and PR3-ANCA positive and with GPA. (bmj.com)
  • Blood investigations to rule out systemic vasculitis (antinuclear antibodies, RA factor, c-ANCA, and p-ANCA) and other infective etiologies including HIV were all negative. (springeropen.com)
  • In these cases, the antibody found is sometimes used in classification, as in ANCA-associated vasculitides. (wikipedia.org)
  • Nearly two decades later, clinicians and scientists from numerous disciplines were invited to Chapel Hill to revisit the nomenclature and participate in the 15th International Vasculitis & ANCA workshop. (wikipedia.org)
  • ANCA vasculitis) and autoimmune diseases (e.g., lupus), as well as congenital or genetic conditions such as polycystic kidney disease. (wikipedia.org)
  • They are detected as a blood test in a number of autoimmune disorders, but are particularly associated with systemic vasculitis, so called ANCA-associated vasculitides. (wikipedia.org)
  • Since it can be associated with the three systemic vasculitides mentioned above, a pauci-immune pattern finding can be associated with antineutrophil cytoplasmic antibodies (ANCA). (wikipedia.org)
  • Therefore, an ANCA test should follow a negative immunofluorescence result in order to distinguish between the above-mentioned systemic vasculitis. (wikipedia.org)

anti-neutrophil cytoplasm

  • The anti-neutrophil cytoplasm antibody-associated vasculitides are complex multi-system disorders with many overlapping clinical features. (ox.ac.uk)
  • Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system. (ucl.ac.uk)

Chronic

  • The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function. (ox.ac.uk)
  • Chronic vasculitis of both large and medium vessels, primarily affecting cranial branches of the arteries arising from the aortic arch. (wikipedia.org)
  • Mastocytosis, including mast cell activation syndrome and eosinophilic esophagitis Chronic fatigue syndrome Systemic vasculitis e.g. (wikipedia.org)

granulomatosis

  • Evidence is lacking for direct pathogenicity of human anti-proteinase-3 (PR3) antibodies in development of systemic vasculitis and granulomatosis with polyangiitis (GPA, Wegener's granulomatosis). (ucl.ac.uk)
  • Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis (WG), is a systemic disorder that involves both granulomatosis and polyangiitis. (wikipedia.org)
  • According to the size of the vessel affected, vasculitis can be classified into: Large vessel: Polymyalgia rheumatica, Takayasu's arteritis, Temporal arteritis Medium vessel: Buerger's disease, Kawasaki disease, Polyarteritis nodosa Small vessel: Behçet's syndrome, Eosinophilic granulomatosis with polyangiitis, Cutaneous vasculitis, Henoch-Schönlein purpura, Microscopic polyannulomatosis ConditionofSome disorders have vasculitis as their main feature. (wikipedia.org)
  • These are: Granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) Microscopic polyangiitis Laboratory tests of blood or body fluids are performed for patients with active vasculitis. (wikipedia.org)
  • ANCAs are associated with small vessel vasculitides including granulomatosis with polyangiitis (previously known as Wegener's granulomatosis), microscopic polyangiitis, primary pauci-immune necrotizing crescentic glomerulonephritis (a type of renal-limited microscopic polyangiitis), eosinophilic granulomatosis with polyangiitis (previously known as Churg-Strauss syndrome) and drug induced vasculitides. (wikipedia.org)
  • A negative pattern or pauci-immune pattern can be associated with systemic vasculitis such as microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (EGPA) or granulomatosis with polyangiitis (GPA). (wikipedia.org)
  • Systemic vasculitis#Pauci-immune Goodpasture Syndrome and Poststrep Glomerulonephritis Microscopic polyangiitis, Eosinophilic granulomatosis with polyangiitis or Granulomatosis with polyangiitis Sattar. (wikipedia.org)
  • This condition is now called "eosinophilic granulomatosis with polyangiitis" to remove all eponyms from the vasculitides. (wikipedia.org)

leukocytoclastic vasculitis

  • A biopsy of a skin lesion reveals leukocytoclastic vasculitis (LCV). (rheumatology.org)

Glomerulonephritis

  • Falk's research focuses on inflammatory and vascular kidney diseases (vasculitis and glomerulonephritis). (wikipedia.org)
  • As an investigator, Falk studies kidney diseases caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs), which are a major cause for the most common forms of aggressive glomerulonephritis and systemic vasculitis in adults. (wikipedia.org)

biopsy

  • If the person has kidney failure or cutaneous vasculitis, a biopsy is obtained from the kidneys. (wikipedia.org)
  • Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy. (wikipedia.org)
  • The definite diagnosis of vasculitis is established after a biopsy of involved organ or tissue, such as skin, sinuses, lung, nerve, brain and kidney. (wikipedia.org)

diseases

  • OBJECTIVES: The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can significantly improve outcomes. (ox.ac.uk)
  • Increased experience of the use of biologic drugs in other immune-mediated inflammatory diseases has led to the application of biologic therapies in the treatment of primary systemic vasculitis. (ox.ac.uk)
  • Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. (wikipedia.org)
  • Myasthenia gravis Getting a regular eye exam may play a role in identifying the signs of some systemic diseases. (wikipedia.org)
  • Almost any part of the eye can give important clues to the diagnosis of systemic diseases. (wikipedia.org)
  • Since 500 B.C., some researchers have believed that the physical condition of the fingernails and toenails can indicate various systemic diseases. (wikipedia.org)
  • Careful examination of the fingernails and toenails may provide clues to underlying systemic diseases[citation needed], since some diseases have been found to cause disruptions in the nail growth process. (wikipedia.org)
  • Pitting also may be caused by a variety of systemic diseases, including reactive arthritis and other connective tissue disorders, sarcoidosis, pemphigus, alopecia areata, and incontinentia pigmenti. (wikipedia.org)

clinical

  • This section deals with the clinical condition primary systemic vasculitis, listing the relevant immunological tests, together with a short explanation of their use. (cmft.nhs.uk)
  • This approach provides a rational basis for clinical management as well as being essential in the conduct of clinical trials and studies in vasculitis, by providing reproducible definitions of relapse, remission and response to therapy for patients with systemic vasculitis. (ox.ac.uk)
  • A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. (ox.ac.uk)
  • OBJECTIVE: Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. (ox.ac.uk)
  • Drugs used to treat vasculitis depend on the severity of the clinical manifestations. (bmj.com)
  • The systemic vasculitides are a diverse group of disorders that demonstrate a wide range of organ involvement and clinical severity. (bmj.com)

Antineutrophil Cytoplasmic

  • Several of these vasculitides are associated with antineutrophil cytoplasmic antibodies. (wikipedia.org)

Antibodies

  • Therefore, we tested whether human anti-PR3 antibodies can induce acute vasculitis in mice with a human immune system. (ucl.ac.uk)

infective endocarditis

  • A possible diagnosis of systemic vasculitis or infective endocarditis was also considered. (springeropen.com)

diagnosis

  • Choroidal granulomas in immunocompetent patients can pose difficulty in diagnosis as in most cases systemic examination may not reveal any evidence of tuberculosis. (springeropen.com)
  • Timely diagnosis with appropriate treatment can improve systemic and ocular disease. (springeropen.com)
  • A provisional diagnosis of multiple choroidal granulomas with systemic involvement was considered. (springeropen.com)

hypersensitivity vasculitis

  • Hypersensitivity vasculitis (allergic vasculitis). (wikipedia.org)
  • on microscopy the appearances are of a hypersensitivity vasculitis, and immunofluorescence demonstrates IgA and C3 (a protein of the complement system) in the blood vessel wall. (wikipedia.org)
  • On the basis of symptoms, it is possible to distinguish HSP from hypersensitivity vasculitis (HV). (wikipedia.org)

disorders

  • The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. (ox.ac.uk)

Consensus Conference

  • In 1994, Falk and Jennette convened an International Consensus Conference that yielded the Chapel Hill Nomenclature for Small Vessel Vasculitis that has now been adopted on a worldwide basis. (wikipedia.org)

nomenclature

Patients

  • We describe humanised monoclonal antibody therapy in four patients with severe systemic vasculitis unresponsive to immunosuppressive drugs. (ox.ac.uk)
  • The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis. (ox.ac.uk)
  • METHODS: A total of 238 patients with vasculitis from seven countries in Europe were evaluated at a single time point. (ox.ac.uk)
  • CONCLUSION: The BVAS v. 3 has been evaluated in a large cohort of patients with vasculitis and the important properties of the tool revalidated. (ox.ac.uk)
  • This study increases the utility of the BVAS v. 3 in different populations of patients with systemic vasculitis. (ox.ac.uk)
  • This paper reviews the current evidence for the standard of care of patients with vasculitis and the role of biologic therapy in primary systemic vasculitis. (ox.ac.uk)
  • 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)has become a widely used imaging tool in patients with suspected Large Vessel Vasculitis, due to the enhanced glucose metabolism of inflamed vessel walls. (wikipedia.org)
  • Almost all patients experience asthma and/or allergic rhinitis, with more than 90% having a history of asthma that is either a new development, or the worsening of pre-existing asthma, which may require systemic corticosteroid treatment. (wikipedia.org)
  • He was also the first to identify the antigen targeted by autoantibodies in patients with systemic vasculitis, which formed the basis for a routinely used diagnostic assay. (wikipedia.org)

giant cell arte

  • Takayasu's arteritis is similar to other forms of vasculitis, including giant cell arteritis which typically affects older individuals. (wikipedia.org)

renal

  • In one case, hypertension was easily controlled with captopril during the time that evidence of healing of renal vasculitis was obtained, likely due to cyclophosphamide and prednisone. (annals.org)
  • Systemic conditions that affect the kidneys (such as diabetes and autoimmune disease) and systemic problems that occur as a result of kidney problems (such as renal osteodystrophy and hypertension) are also studied in nephrology. (wikipedia.org)

kidneys

  • Further, IgA nephropathy typically only affects the kidneys while HSP is a systemic disease. (wikipedia.org)

small-vessel vasculitis

  • Henoch-Schönlein purpura is a small-vessel vasculitis in which complexes of immunoglobulin A (IgA) and complement component 3 (C3) are deposited on arterioles, capillaries, and venules. (wikipedia.org)

illness

  • This patient had LCV of unknown cause, with no evidence of systemic vasculitis, underlying connective tissue disease, or other systemic illness. (rheumatology.org)
  • Paradoxically, the vasculitides seem to paralyze the clinician with regard to choosing diagnostic tests, determining the need for immediate steroid or cytotoxic therapy, and deciding the specific illness. (annals.org)
  • A 26-year-old male Indian patient presented with bilateral blurred vision and systemic illness with vasculitis-like features. (springeropen.com)
  • Some people develop an initial "inflammatory phase" characterized by systemic illness with signs and symptoms of malaise, fever, night sweats, weight loss, joint pain, fatigue, and fainting. (wikipedia.org)
  • Some individuals with Takayasu's arteritis may present with only late vascular changes, without a preceding systemic illness. (wikipedia.org)

pauci-immune

  • Pauci-immune (pauci- Latin: few, little) vasculitis is a form of vasculitis that is associated with minimal evidence of hypersensitivity upon immunofluorescent staining for IgG. (wikipedia.org)

symptoms

  • She has no systemic features such as fever or weight loss, and no circulatory, pulmonary, gastrointestinal, or other symptoms. (rheumatology.org)
  • Local and systemic symptoms become more widespread and are compounded by new symptoms from the vasculitis. (wikipedia.org)

affects

  • Although GPA affects small- and medium-size vessels, it is formally classified as one of the small vessel vasculitides in the Chapel Hill system. (wikipedia.org)
  • Henoch-Schönlein purpura (HSP), also known as IgA vasculitis, anaphylactoid purpura, purpura rheumatica, and Schönlein-Henoch purpura, is a disease of the skin, mucous membranes, and sometimes other organs that most commonly affects children. (wikipedia.org)
  • A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole. (wikipedia.org)

forms of vasculitis

  • However, the causes of many forms of vasculitis are poorly understood. (wikipedia.org)

Hypertension

  • To the editor: Drs. White and Schambelan (1) reported in the February 1980 issue two cases of hypertension with hyperreninemia complicating systemic necrotizing vasculitis. (annals.org)

remission

  • Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy. (ox.ac.uk)

cutaneous

  • Arthritis: Pain or swelling (60%), often initially diagnosed as rheumatoid arthritis Skin: nodules on the elbow, purpura, various others (see cutaneous vasculitis) Nervous system: occasionally sensory neuropathy (10%) and rarely mononeuritis multiplex Heart, gastrointestinal tract, brain, other organs: rarely affected. (wikipedia.org)

Necrotizing

  • Necrotizing vasculitis also called Systemic necrotizing vasculitus (SNV) is a category of vasculitis, comprising vasculitides that present with necrosis. (wikipedia.org)
  • Systemic necrotizing vasculitis and aneurysm formation affecting both medium and small arteries. (wikipedia.org)
  • It is a type of systemic necrotizing vasculitis. (wikipedia.org)

ocular

  • There was a good systemic and ocular response to anti-tubercular therapy with resolution of lesions. (springeropen.com)

Commonly

  • Takayasu's arteritis (also known as Takayasu's disease, "aortic arch syndrome," "nonspecific aortoarteritis," and "pulseless disease") is a form of large vessel granulomatous vasculitis with massive intimal fibrosis and vascular narrowing, most commonly affecting often young or middle-age women of Asian descent, though anyone can be affected. (wikipedia.org)

classification

  • EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. (ox.ac.uk)
  • CONCLUSIONS: Limitations in current classification criteria and definitions for vasculitis have been identified and suggestions provided for improvement. (ox.ac.uk)
  • The Chapel Hill Consensus Conferences (CHCC) (1994 and 2012) are a pair of international conferences which addressed the need of standardized classification system for systemic vasculitides. (wikipedia.org)

assessment

  • Disease assessment in systemic vasculitis. (ox.ac.uk)
  • This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. (ox.ac.uk)
  • Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's global assessment (PGA), the physician's treatment decision, CRP and the vasculitis damage index (VDI) to demonstrate that the BVAS v. 3 measures disease activity. (ox.ac.uk)

organs

  • Our case emphasizes that, although uncommon, tuberculosis can involve multiple organs without pulmonary involvement and may mimic systemic vasculitis, it is not mandatory to have pulmonary findings for a confirmation of tuberculosis. (springeropen.com)

signs

  • Signs of a systemic disease may be evident on the outer surface of the eye (eyelids, conjunctiva and cornea), middle of the eye and at the back of the eye (retina). (wikipedia.org)

arteries

  • Systemic vasculitis of medium and small arteries, including venules and arterioles. (wikipedia.org)

tuberculosis

  • We report a case of bilateral multiple choroidal granulomas with systemic vasculitis-like features and disseminated tuberculosis in an immunocompetent patient without pulmonary involvement. (springeropen.com)