Hyperalgesia
Stress, Mechanical
Biomechanical Phenomena
Mechanical Phenomena
Respiration, Artificial
Mechanotransduction, Cellular
Tensile Strength
Elastic Modulus
Insulin-like growth factor-1 induces Mdm2 and down-regulates p53, attenuating the myocyte renin-angiotensin system and stretch-mediated apoptosis. (1/9460)
Insulin-like growth factor (IGF)-1 inhibits apoptosis, but its mechanism is unknown. Myocyte stretching activates p53 and p53-dependent genes, leading to the formation of angiotensin II (Ang II) and apoptosis. Therefore, this in vitro system was used to determine whether IGF-1 interfered with p53 function and the local renin-angiotensin system (RAS), decreasing stretch-induced cell death. A single dose of 200 ng/ml IGF-1 at the time of stretching decreased myocyte apoptosis 43% and 61% at 6 and 20 hours. Ang II concentration was reduced 52% at 20 hours. Additionally, p53 DNA binding to angiotensinogen (Aogen), AT1 receptor, and Bax was markedly down-regulated by IGF-1 via the induction of Mdm2 and the formation of Mdm2-p53 complexes. Concurrently, the quantity of p53, Aogen, renin, AT1 receptor, and Bax was reduced in stretched myocytes exposed to IGF-1. Conversely, Bcl-2 and the Bcl-2-to-Bax protein ratio increased. The effects of IGF-1 on cell death, Ang II synthesis, and Bax protein were the consequence of Mdm2-induced down-regulation of p53 function. In conclusion, the anti-apoptotic impact of IGF-1 on stretched myocytes was mediated by its capacity to depress p53 transcriptional activity, which limited Ang II formation and attenuated the susceptibility of myocytes to trigger their endogenous cell death pathway. (+info)Fibrocartilage in tendons and ligaments--an adaptation to compressive load. (2/9460)
Where tendons and ligaments are subject to compression, they are frequently fibrocartilaginous. This occurs at 2 principal sites: where tendons (and sometimes ligaments) wrap around bony or fibrous pulleys, and in the region where they attach to bone, i.e. at their entheses. Wrap-around tendons are most characteristic of the limbs and are commonly wider at their point of bony contact so that the pressure is reduced. The most fibrocartilaginous tendons are heavily loaded and permanently bent around their pulleys. There is often pronounced interweaving of collagen fibres that prevents the tendons from splaying apart under compression. The fibrocartilage can be located within fascicles, or in endo- or epitenon (where it may protect blood vessels from compression or allow fascicles to slide). Fibrocartilage cells are commonly packed with intermediate filaments which could be involved in transducing mechanical load. The ECM often contains aggrecan which allows the tendon to imbibe water and withstand compression. Type II collagen may also be present, particularly in tendons that are heavily loaded. Fibrocartilage is a dynamic tissue that disappears when the tendons are rerouted surgically and can be maintained in vitro when discs of tendon are compressed. Finite element analyses provide a good correlation between its distribution and levels of compressive stress, but at some locations fibrocartilage is a sign of pathology. Enthesis fibrocartilage is most typical of tendons or ligaments that attach to the epiphyses of long bones where it may also be accompanied by sesamoid and periosteal fibrocartilages. It is characteristic of sites where the angle of attachment changes throughout the range of joint movement and it reduces wear and tear by dissipating stress concentration at the bony interface. There is a good correlation between the distribution of fibrocartilage within an enthesis and the levels of compressive stress. The complex interlocking between calcified fibrocartilage and bone contributes to the mechanical strength of the enthesis and cartilage-like molecules (e.g. aggrecan and type II collagen) in the ECM contribute to its ability to withstand compression. Pathological changes are common and are known as enthesopathies. (+info)Receptor mechanisms underlying heterogenic reflexes among the triceps surae muscles of the cat. (3/9460)
The soleus (S), medial gastrocnemius (MG), and lateral gastrocnemius (LG) muscles of the cat are interlinked by rapid spinal reflex pathways. In the decerebrate state, these heterogenic reflexes are either excitatory and length dependent or inhibitory and force dependent. Mechanographic analysis was used to obtain additional evidence that the muscle spindle primary ending and the Golgi tendon organ provide the major contributions to these reflexes, respectively. The tendons of the triceps surae muscles were separated and connected to independent force transducers and servo-controlled torque motors in unanesthetized, decerebrate cats. The muscles were activated as a group using crossed-extension reflexes. Electrical stimulation of the caudal cutaneous sural nerve was used to provide a particularly strong activation of MG and decouple the forces of the triceps surae muscles. During either form of activation, the muscles were stretched either individually or in various combinations to determine the strength and characteristics of autogenic and heterogenic feedback. The corresponding force responses, including both active and passive components, were measured during the changing background tension. During activation of the entire group, the excitatory, heterogenic feedback linking the three muscles was found to be strongest onto LG and weakest onto MG, in agreement with previous results concerning the strengths of heteronymous Ia excitatory postsynaptic potentials among the triceps surae muscles. The inhibition, which is known to affect only the soleus muscle, was dependent on active contractile force and was detected essentially as rapidly as length dependent excitation. The inhibition outlasted the excitation and was blocked by intravenous strychnine. These results indicate that the excitatory and inhibitory effects are dominated by feedback from primary spindle receptors and Golgi tendon organs. The interactions between these two feedback pathways potentially can influence both the mechanical coupling between ankle and knee. (+info)Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear. (4/9460)
Adhesion of platelets to sites of vascular injury is critical for hemostasis and thrombosis and is dependent on the binding of the vascular adhesive protein von Willebrand factor (vWf) to the glycoprotein (GP) Ib-V-IX complex on the platelet surface. A unique but poorly defined characteristic of this receptor/ligand interaction is its ability to support platelet adhesion under conditions of high shear stress. To examine the structural domains of the GPIb-V-IX complex involved in mediating cell adhesion under flow, we have expressed partial (GPIb-IX), complete (GPIb-V-IX), and mutant (GPIbalpha cytoplasmic tail mutants) receptor complexes on the surface of Chinese hamster ovary (CHO) cells and examined their ability to adhere to a vWf matrix in flow-based adhesion assays. Our studies demonstrate that the partial receptor complex (GPIb-IX) supports CHO cell tethering and rolling on a bovine or human vWf matrix under flow. The adhesion was specifically inhibited by an anti-GPIbalpha blocking antibody (AK2) and was not observed with CHO cells expressing GPIbbeta and GPIX alone. The velocity of rolling was dependent on the level of shear stress, receptor density, and matrix concentration and was not altered by the presence of GPV. In contrast to selectins, which mediate cell rolling under conditions of low shear (20-200 s-1), GPIb-IX was able to support cell rolling at both venous (150 s-1) and arterial (1500-10,500 s-1) shear rates. Studies with a mutant GPIbalpha receptor subunit lacking the binding domain for actin-binding protein demonstrated that the association of the receptor complex with the membrane skeleton is not essential for cell tethering or rolling under low shear conditions, but is critical for maintaining adhesion at high shear rates (3000-6000 s-1). These studies demonstrate that the GPIb-IX complex is sufficient to mediate cell rolling on a vWf matrix at both venous and arterial levels of shear independent of other platelet adhesion receptors. Furthermore, our results suggest that the association between GPIbalpha and actin-binding protein plays an important role in enabling cells to remain tethered to a vWf matrix under conditions of high shear stress. (+info)Cloning of a stretch-inhibitable nonselective cation channel. (5/9460)
A homologue of the capsaicin receptor-nonselective cation channel was cloned from the rat kidney to investigate a mechanosensitive channel. We found this channel to be inactivated by membrane stretch and have designated it stretch-inactivated channel (SIC). SIC encodes a 563-amino acid protein with putative six transmembrane segments. The cDNA was expressed in mammalian cells, and electophysiological studies were performed. SIC-induced large cation currents were found to be regulated by cell volume, with currents being stimulated by cell shrinkage and inhibited by cell swelling. Single channel analysis showed a conductance of 250 pS with cation permeability (PCl/PNa < 0.1), and the channel possessed some of the characteristics of a stretch-inactivated channel in that it was permeable to calcium, sensitive to membrane stretch, and blocked by Gd3+. Therefore, we cloned one of the mechanosensitive cation channels of mammals, which is considered to regulate Ca2+ influx in response to mechanical stress on the cell membrane. (+info)Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ibalpha under flow. (6/9460)
We have used recombinant von Willebrand factor (vWF) fragments to investigate the properties regulating A1 domain interaction with platelet glycoprotein (GP) Ibalpha. One fragment, rvWF508-704, represented the main portion of domain A1 (mature subunit residues 497-716) within the Cys509-Cys695 disulfide loop. The other, rvWF445-733, included the carboxyl-terminal region of domain D3, preceding A1, and corresponded to the proteolytic fragment originally identified as the GP Ibalpha-binding site (residues 449-728). Conformational changes were induced by reduction and alkylation of the Cys509-Cys695 bond and/or exposure to acidic pH. The cyclic rvWF445-733 fragment exhibited the function of native vWF A1 domain. When immobilized onto a surface, it tethered platelets at shear rates up to 6,300 s-1 mediating low velocity translocation but not stable attachment; in solution, it exhibited limited interaction with GP Ibalpha. In contrast, fragments with perturbed conformation could not tether platelets at high shear rates but promoted stable adhesion at lower shear and bound tightly to GP Ibalpha. Only in the presence of the exogenous modulator, botrocetin, did cyclic rvWF445-733 mediate irreversible adhesion. Thus, conformational transitions in the vWF A1 domain may influence differentially the efficiency of bond formation with GP Ibalpha and the stability of binding. (+info)Calculation of a Gap restoration in the membrane skeleton of the red blood cell: possible role for myosin II in local repair. (7/9460)
Human red blood cells contain all of the elements involved in the formation of nonmuscle actomyosin II complexes (V. M. Fowler. 1986. J. Cell. Biochem. 31:1-9; 1996. Curr. Opin. Cell Biol. 8:86-96). No clear function has yet been attributed to these complexes. Using a mathematical model for the structure of the red blood cell spectrin skeleton (M. J. Saxton. 1992. J. Theor. Biol. 155:517-536), we have explored a possible role for myosin II bipolar minifilaments in the restoration of the membrane skeleton, which may be locally damaged by major mechanical or chemical stress. We propose that the establishment of stable links between distant antiparallel actin protofilaments after a local myosin II activation may initiate the repair of the disrupted area. We show that it is possible to define conditions in which the calculated number of myosin II minifilaments bound to actin protofilaments is consistent with the estimated number of myosin II minifilaments present in the red blood cells. A clear restoration effect can be observed when more than 50% of the spectrin polymers of a defined area are disrupted. It corresponds to a significant increase in the spectrin density in the protein free region of the membrane. This may be involved in a more complex repair process of the red blood cell membrane, which includes the vesiculation of the bilayer and the compaction of the disassembled spectrin network. (+info)The forward rate of binding of surface-tethered reactants: effect of relative motion between two surfaces. (8/9460)
The reaction of molecules confined to two dimensions is of interest in cell adhesion, specifically for the reaction between cell surface receptors and substrate-bound ligand. We have developed a model to describe the overall rate of reaction of species that are bound to surfaces under relative motion, such that the Peclet number is order one or greater. The encounter rate between reactive species is calculated from solution of the two-dimensional convection-diffusion equation. The probability that each encounter will lead to binding depends on the intrinsic rate of reaction and the encounter duration. The encounter duration is obtained from the theory of first passage times. We find that the binding rate increases with relative velocity between the two surfaces, then reaches a plateau. This plateau indicates that the increase in the encounter rate is counterbalanced by the decrease in the encounter duration as the relative velocity increases. The binding rate is fully described by two dimensionless parameters, the Peclet number and the Damkohler number. We use this model to explain data from the cell adhesion literature by incorporating these rate laws into "adhesive dynamics" simulations to model the binding of a cell to a surface under flow. Leukocytes are known to display a "shear threshold effect" when binding selectin-coated surfaces under shear flow, defined as an increase in bind rate with shear; this effect, as calculated here, is due to an increase in collisions between receptor and ligand with increasing shear. The model can be used to explain other published data on the effect of wall shear rate on the binding of cells to surfaces, specifically the mild decrease in binding within a fixed area with increasing shear rate. (+info)Hyperalgesia is a medical term that describes an increased sensitivity to pain. It occurs when the nervous system, specifically the nociceptors (pain receptors), become excessively sensitive to stimuli. This means that a person experiences pain from a stimulus that normally wouldn't cause pain or experiences pain that is more intense than usual. Hyperalgesia can be a result of various conditions such as nerve damage, inflammation, or certain medications. It's an important symptom to monitor in patients with chronic pain conditions, as it may indicate the development of tolerance or addiction to pain medication.
Mechanical stress, in the context of physiology and medicine, refers to any type of force that is applied to body tissues or organs, which can cause deformation or displacement of those structures. Mechanical stress can be either external, such as forces exerted on the body during physical activity or trauma, or internal, such as the pressure changes that occur within blood vessels or other hollow organs.
Mechanical stress can have a variety of effects on the body, depending on the type, duration, and magnitude of the force applied. For example, prolonged exposure to mechanical stress can lead to tissue damage, inflammation, and chronic pain. Additionally, abnormal or excessive mechanical stress can contribute to the development of various musculoskeletal disorders, such as tendinitis, osteoarthritis, and herniated discs.
In order to mitigate the negative effects of mechanical stress, the body has a number of adaptive responses that help to distribute forces more evenly across tissues and maintain structural integrity. These responses include changes in muscle tone, joint positioning, and connective tissue stiffness, as well as the remodeling of bone and other tissues over time. However, when these adaptive mechanisms are overwhelmed or impaired, mechanical stress can become a significant factor in the development of various pathological conditions.
I'm sorry for any confusion, but "mechanical processes" is not a specific medical term. However, in a broader scientific context, mechanical processes refer to actions or events that involve forces and the movement or conversion of energy. This could include physical movements or manipulations of the body or bodily systems, such as surgical procedures, or the functioning of mechanical medical devices like pacemakers. If you have a more specific context in mind, I'd be happy to help further!
Biomechanics is the application of mechanical laws to living structures and systems, particularly in the field of medicine and healthcare. A biomechanical phenomenon refers to a observable event or occurrence that involves the interaction of biological tissues or systems with mechanical forces. These phenomena can be studied at various levels, from the molecular and cellular level to the tissue, organ, and whole-body level.
Examples of biomechanical phenomena include:
1. The way that bones and muscles work together to produce movement (known as joint kinematics).
2. The mechanical behavior of biological tissues such as bone, cartilage, tendons, and ligaments under various loads and stresses.
3. The response of cells and tissues to mechanical stimuli, such as the way that bone tissue adapts to changes in loading conditions (known as Wolff's law).
4. The biomechanics of injury and disease processes, such as the mechanisms of joint injury or the development of osteoarthritis.
5. The use of mechanical devices and interventions to treat medical conditions, such as orthopedic implants or assistive devices for mobility impairments.
Understanding biomechanical phenomena is essential for developing effective treatments and prevention strategies for a wide range of medical conditions, from musculoskeletal injuries to neurological disorders.
I'm sorry for any confusion, but "mechanical phenomena" is not a standard medical term. The term "mechanical phenomenon" is more commonly used in the fields of physics and engineering to refer to events or processes that involve physical forces and movements, such as the movement of a lever or the flow of a fluid due to pressure differences.
If you have any questions about a specific medical concept or condition, I would be happy to try to help you with that instead!
Artificial respiration is an emergency procedure that can be used to provide oxygen to a person who is not breathing or is breathing inadequately. It involves manually forcing air into the lungs, either by compressing the chest or using a device to deliver breaths. The goal of artificial respiration is to maintain adequate oxygenation of the body's tissues and organs until the person can breathe on their own or until advanced medical care arrives. Artificial respiration may be used in conjunction with cardiopulmonary resuscitation (CPR) in cases of cardiac arrest.
Cellular mechanotransduction is the process by which cells convert mechanical stimuli into biochemical signals, resulting in changes in cell behavior and function. This complex process involves various molecular components, including transmembrane receptors, ion channels, cytoskeletal proteins, and signaling molecules. Mechanical forces such as tension, compression, or fluid flow can activate these components, leading to alterations in gene expression, protein synthesis, and cell shape or movement. Cellular mechanotransduction plays a crucial role in various physiological processes, including tissue development, homeostasis, and repair, as well as in pathological conditions such as fibrosis and cancer progression.
In medicine, elasticity refers to the ability of a tissue or organ to return to its original shape after being stretched or deformed. This property is due to the presence of elastic fibers in the extracellular matrix of the tissue, which can stretch and recoil like rubber bands.
Elasticity is an important characteristic of many tissues, particularly those that are subjected to repeated stretching or compression, such as blood vessels, lungs, and skin. For example, the elasticity of the lungs allows them to expand and contract during breathing, while the elasticity of blood vessels helps maintain normal blood pressure by allowing them to expand and constrict in response to changes in blood flow.
In addition to its role in normal physiology, elasticity is also an important factor in the diagnosis and treatment of various medical conditions. For example, decreased elasticity in the lungs can be a sign of lung disease, while increased elasticity in the skin can be a sign of aging or certain genetic disorders. Medical professionals may use techniques such as pulmonary function tests or skin biopsies to assess elasticity and help diagnose these conditions.
Physical stimulation, in a medical context, refers to the application of external forces or agents to the body or its tissues to elicit a response. This can include various forms of touch, pressure, temperature, vibration, or electrical currents. The purpose of physical stimulation may be therapeutic, as in the case of massage or physical therapy, or diagnostic, as in the use of reflex tests. It is also used in research settings to study physiological responses and mechanisms.
In a broader sense, physical stimulation can also refer to the body's exposure to physical activity or exercise, which can have numerous health benefits, including improving cardiovascular function, increasing muscle strength and flexibility, and reducing the risk of chronic diseases.
Tensile strength is a material property that measures the maximum amount of tensile (pulling) stress that a material can withstand before failure, such as breaking or fracturing. It is usually measured in units of force per unit area, such as pounds per square inch (psi) or pascals (Pa). In the context of medical devices or biomaterials, tensile strength may be used to describe the mechanical properties of materials used in implants, surgical tools, or other medical equipment. High tensile strength is often desirable in these applications to ensure that the material can withstand the stresses and forces it will encounter during use.
The Elastic Modulus, also known as Young's modulus, is a measure of the stiffness of a material. It is defined as the ratio of stress (force per unit area) to strain (partial deformation or change in length per unit length) in the elastic range of deformation of a material. In other words, it measures how much a material will deform (change in length or size) when subjected to a given amount of force. A higher elastic modulus indicates that a material is stiffer and less likely to deform, while a lower elastic modulus indicates that a material is more flexible and will deform more easily. The elastic modulus is typically expressed in units of Pascals (Pa) or Gigapascals (GPa).
Mechanical Ventilators are medical devices that assist with breathing by providing mechanical ventilation to patients who are unable to breathe sufficiently on their own. These machines deliver breaths to the patient through an endotracheal tube or a tracheostomy tube, which is placed in the windpipe (trachea). Mechanical Ventilators can be set to deliver breaths at specific rates and volumes, and they can also be adjusted to provide varying levels of positive end-expiratory pressure (PEEP) to help keep the alveoli open and improve oxygenation.
Mechanical ventilation is typically used in critical care settings such as intensive care units (ICUs), and it may be employed for a variety of reasons, including respiratory failure, sedation, neuromuscular disorders, or surgery. Prolonged use of mechanical ventilation can lead to complications such as ventilator-associated pneumonia, muscle weakness, and decreased cardiac function, so the goal is usually to wean patients off the ventilator as soon as possible.
Stress (mechanics)
Vibratory stress relief
Shear stress
Critical resolved shear stress
Stress-strain curve
Stress intensity factor
Hydrostatic stress
Stress concentration
Stress triaxiality
Flow stress
Peierls stress
Stress-strength analysis
Cyclic stress
Stress corrosion cracking
Piezoelectricity
Stress incontinence
Residual stress
LGBT trauma
Volumetric pipette
Michael Walker (knifemaker)
Hiroshi Tada (engineer)
Rainflow-counting algorithm
Side-channel attack
Mittag-Leffler function
Marman clamp
Non-intrusive stress measurement system
Embrittlement
Ramberg-Osgood relationship
Ductility
Nanoparticle
Mechanical Stress Testing
Abstract] EFFECT OF OXIDATION STRESS ON THE MECHANICAL PROPERTY OF HUMAN HAIR
Essentials of Mechanical Stress Analysis - Amir Javidinejad - Innbundet (9781032317557) » Bokkilden
How mechanical and electrical stimuli affect bacteria filamentation, a major cell stress response | Filcellstress | Project |...
Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway
Keyboard Fidget Toy Mechanical Switch Keyboard Fingertip Fidget Button Stress Relief Sensory Toys Pocket Keyboard Toys - Buy...
Evaluation of notch stress intensities at sharp V-notches using a point substitution method | Mechanical Department | IITG
Proliferation of Atomic Shuffling through Mechanical Stress on Cationic Disorder Li4FeMoO6 as a Cathode Material for a Lithium...
Engineering professors team up to measure mechanical stresses and strains | Texas A&M University Engineering
A System for Calibration and Reliability Testing of MEMS Devices Under Mechanical Stress - Conference papers - VDE Publishing...
Stress, Mechanical - McMaster Experts
Advances in Topology Optimization: Neural Network Approaches for Multi-Matieral, Thermo-Mechanical, and Stress-Constrained...
In-vivo imaging of root growth in response to localized mechanical stress - Epsilon Archive for Student Projects
Casting and stress-strain simulations of a cast ductile iron component using microstructure based mechanical behavior
Modeling of Mechanical Stress Exerted by Cholesterol Crystallization on Atherosclerotic Plaques | NTU Singapore
JKU-FoDok Forschungsdokumentation der Universit t Linz - Gehaltener Vortrag - A Novel Measurement Setup for Evaluating the...
IJMS | Free Full-Text | Mechanical and Immunological Regulation in Wound Healing and Skin Reconstruction
Open model for external mechanical stress of semiconductors and MEMS
Frontiers | Mechanical Aspects of Deformation-Induced Surface Roughening in the Presence of Inclusions in a Subsurface Layer....
Mechanical Engineer Stress
PHYSIOLOGY OF MECHANICAL STRESS-INDUCED NEEDLE LOSS IN POSTHARVEST BALSAM FIR (ABIES BALSAMEA L.)
Research unit 2743 - mechanical stress protection - izb
Mechanical stress reduces plant yield and increases desease
What is Stress in the Strength of Materials? - Mechanical Booster
Mechanical cell competition kills cells via induction of lethal p53 levels | Nature Communications
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Mechanical stress downregulates MHC class I expression on human cancer cells membrane
Strains2
- Texas A&M College of Engineering professors Drs. Dimitris Lagoudas, Jodie Lutkenhaus and James Boyd have discovered how to measure mechanical stresses and strains in energy storage materials. (tamu.edu)
- To combat this, her research looks to create an instrument that measures mechanical stresses and strains in energy storage materials as they charge and discharge. (tamu.edu)
Residual stresses9
- The mechanical behavior of the component is determined by the casting process, and factors as component geometry and casting process parameters are known to affect solidification and microstructure formation throughout the component and cause local variations in mechanical behavior as well as residual stresses. (diva-portal.org)
- Though residual stresses are known to be an important factor in the mechanical behavior of the component, the importance of local mechanical behavior is not well established and the material is typically considered homogeneous throughout the component. (diva-portal.org)
- In addition the residual stresses are considered. (diva-portal.org)
- When the applied load is low and the component is subjected to stress levels well below the yield strength of the material, the residual stresses highly affects the simulation results while the effect of local material behavior is low. (diva-portal.org)
- As the applied load increases and the stress level in the component approaches and passes the yield strength, the effect of residual stresses diminishes while the effect of local mechanical behavior increases. (diva-portal.org)
- It is proposed that it is important to include both local mechanical behavior and residual stresses in stress-strain simulations to predict the true mechanical behavior of the component. (diva-portal.org)
- Due to the nature of welding process involving localized heat generation from moving heat source (s), rapid heating in the welded structures, and subsequent rapid cooling, problems such as residual stresses and distortions of welded structures remain great challenges to welding practitioners, designers and modeler. (intechopen.com)
- In recent years, various aspects and interests in the numerical modeling of welding residual stresses and distortions, mostly using finite element method, have been elaborated by researchers. (intechopen.com)
- Teng & Lin (1998 ) predicted the residual stresses during one-pass arc welding in steel plate using ANSYS software and discussed the effects of travel speed, specimen size, external mechanical constraints and preheating on the residual stresses. (intechopen.com)
Finite element model2
- Article: Strain and stress analysis of the oxide film surface in the chemical mechanical polishing process Journal: International Journal of Computer Applications in Technology (IJCAT) 2006 Vol.26 No.4 pp.233 - 241 Abstract: A two-dimensional axisymmetric quasi-static finite element model for a chemical mechanical polishing (CMP) process of 12″ wafer was established. (inderscience.com)
- A two-dimensional axisymmetric quasi-static finite element model for a chemical mechanical polishing (CMP) process of 12″ wafer was established. (inderscience.com)
Thermo-mechanical4
- This approach accommodates multi-material, thermo-mechanical, and stress-related objectives, or constraints, ensuring safe and efficient designs. (anl.gov)
- High density 3D-LSI with W-TSV for signal line and Cu-TSV for power/GND line, and Cu-TSV containing W stress absorbing layers were investigated for the induced thermo-mechanical stress in 3D-LSI Si die/wafer after wafer thinning and bonding using micro-Raman spectroscopic technique. (elsevierpure.com)
- Stress mapping analysis revealed that W-TSV has induced less thermo-mechanical stress in LSI Si, whereas the Cu-TSV has induced large amount of stress. (elsevierpure.com)
- 300 MPa of compressive stress after heating at 400 °C. This property can be readily employed to minimize the residual thermo-mechanical stress in the bonded high density 3D-LSI. (elsevierpure.com)
Tissues5
- Moreover, increased IGF-1 promotes hypertrophy of various tissues [ 14 - 17 ], and mechanical stress plays a vital role in IGF-1 formation [ 18 , 19 ]. (hindawi.com)
- Few long-term effects are expect from mechanical conditioning of transplants sincere productive tissues generally are not treat. (hortomallas.com)
- Here, we used computational modeling and engineered epithelial tissues of precise geometry to define the experimental parameters that are required to measure directly the mechanical stress profile of 3D tissues embedded within native type I collagen. (princeton.edu)
- Spatially resolved mechanical maps can provide insight into the types and magnitudes of physical parameters that are sensed and interpreted by multicellular tissues during normal and pathological processes. (princeton.edu)
- In conclusion, preconditioning on healing tissues can introduce mechanical data bias when having extensive tissue strength diversity. (lu.se)
External mechanical2
- Batteries and capacitors can fail through the different effects of internal and external mechanical stresses. (tamu.edu)
- GIACOMINI, R. Open model for external mechanical stress of semiconductors and MEMS.IEEE International Conference on Microelectronic Test Structures, p. 189-193, March, 2018. (edu.br)
Tensile stress3
- When a body is subjected to two equal and opposite pulls, then the stress induced in the body is called tensile stress. (mechanicalbooster.com)
- Tensile stress results in an increase in length and a decrease in the cross-section of the area of the body. (mechanicalbooster.com)
- For example, an object being pulled apart, such as a stretched elastic band, is subject to tensile stress and may undergo elongation. (wikipedia.org)
Vibration3
- With mechanical stress testing, the effects of vibration over a wide range of frequency and acceleration levels can be simulated as well as shock, free fall, drop, tumble and impact according to IEC 60068-series. (nemko.com)
- As a Mechanical Engineer you will be responsible for stress, vibration, and heat transfer analyses. (jobmove.com)
- Mechanical stress "thigmomorphogenesis," whereas plant response to a nontactile (shaking, vibration, wind) treatment was termed "seismomorphogenesis" by Mitchell et al. (hortomallas.com)
Deformation9
- Mechanical damage limits the cycle life of batteries, so new hardware and models are needed to interpret experimental measurements to separate the effects of mass diffusion, reactions, inelastic deformation and mechanical damage. (tamu.edu)
- Mechanical Aspects of Deformation-Induced Surface Roughening in the Presence of Inclusions in a Subsurface Layer. (frontiersin.org)
- The mechanical aspects of deformation-induced surface roughening inherent in microstructural inhomogeneity are studied numerically using single inclusion models. (frontiersin.org)
- In continuum mechanics, stress is a physical quantity that describes forces present during deformation. (wikipedia.org)
- Stress expresses the internal forces that neighbouring particles of a continuous material exert on each other, while strain is the measure of the relative deformation of the material. (wikipedia.org)
- Any strain (deformation) of a solid material generates an internal elastic stress, analogous to the reaction force of a spring, that tends to restore the material to its original non-deformed state. (wikipedia.org)
- If the deformation changes gradually with time, even in fluids there will usually be some viscous stress, opposing that change. (wikipedia.org)
- Significant stress may exist even when deformation is negligible or non-existent (a common assumption when modeling the flow of water). (wikipedia.org)
- Stress that exceeds certain strength limits of the material will result in permanent deformation (such as plastic flow, fracture, cavitation) or even change its crystal structure and chemical composition. (wikipedia.org)
Circumferential6
- We developed a two-dimensional finite element method model of atherosclerotic plaques containing expanding cholesterol crystals and investigated the effect of the magnitude and distribution of crystallization on the peak circumferential stress born by the cap. (ntu.edu.sg)
- and (3) spatial distributions of cholesterol crystals have a significant impact on the peak circumference stress: evenly distributed cholesterol crystals exert less peak circumferential stress on the cap than concentrated crystals. (ntu.edu.sg)
- In their paper, they compare the maximum circumferential stress which appears on the Inner side of the longitudinal cross section planes of the hollow cylinder, the stresses being determined using several different methods: curved beam theory, straight beam theory and finite element method (FEM). (sv-jme.eu)
- They found that the maximum circumferential stresses determined by the straight beam theory and FEM are almost the same, whereas the other methods give lower values of maximum circumferential stresses. (sv-jme.eu)
- Large differences among the maximum circumferential stresses occur near the inner radii. (sv-jme.eu)
- By the curved beam theory and FEM, the maximum circumferential stresses Increase for radii ration from 0.15 downwards but, using the other two methods the same stresses decrease at these radii ratia. (sv-jme.eu)
Fracture2
- With rise of temperature, molecular bonds weakens and fracture occurs at a lesser load, hence area under stress strain curve decreases. (sanfoundry.com)
- Karjalainen-Roikonen, P & Wallin, K 1992, Analysis of fracture mechanical tests for stress corrosion cracking . (vtt.fi)
Homogeneous2
- The specimen?s shape and test setup were optimized concerning a homogeneous mechanical stress distribution and are presented in this paper. (jku.at)
- On a flat free surface of a homogeneous material there are no stresses likely to cause out-of-plane displacements. (frontiersin.org)
Strain13
- The strain, stress and non-uniformity of oxide film surface are examined. (inderscience.com)
- The findings indicate that the axial strain was the maximum in strain components and its peak occurred at the end, the axial stress had a similar trend as the axial strain, and the elastic modulus and the thickness of the pad and carrier load would significantly affect the axial strain, the von Mises stress and the non-uniformity, but those of the film have little effect. (inderscience.com)
- The current work aims to investigate the coupling between simulation of solidification, microstructure and local variations in mechanical behavior and stress-strain simulation. (diva-portal.org)
- In particular the predicted strain level is heavily affected by the use of local mechanical behavior. (diva-portal.org)
- It has been shown that all stress and strain tensor components in the vicinity of inclusions take on non-zero values, including those directed across the load axis. (frontiersin.org)
- Thus, the free surface becomes rough under the action of internal forces originated from the inhomogeneous stress-strain fields. (frontiersin.org)
- On the other hand, the roughness pattern can be used for non-destructive testing of the material stress-strain state. (frontiersin.org)
- Answer:a Explanation: Tension test determines the parameters related to stress strain curve and also reduction and elongation in area and length can be found respectively. (sanfoundry.com)
- 2. Proportional Limit is defined as the stress at which the stress strain curves begins to deviate from the straight line. (sanfoundry.com)
- Answer:a Explanation: Proportional limit is the point of deviation in stress strain curve. (sanfoundry.com)
- Strain inside a material may arise by various mechanisms, such as stress as applied by external forces to the bulk material (like gravity) or to its surface (like contact forces, external pressure, or friction). (wikipedia.org)
- The relation between mechanical stress, strain, and the strain rate can be quite complicated, although a linear approximation may be adequate in practice if the quantities are sufficiently small. (wikipedia.org)
- With those tools, Augustin-Louis Cauchy was able to give the first rigorous and general mathematical model of a deformed elastic body by introducing the notions of stress and strain. (wikipedia.org)
Stimulation8
- Bio-Mechanical Stimulation, or BMS, can be a form of massage that employs mechanical tactics to assist the body cure. (techdirt.stream)
- It was our objective to study the role of mechanical stimulation on fibronectin (FN) reorganization and recruitment by exposing fibroblasts to shear fluid flow and equibiaxial stretch. (nature.com)
- Mechanical stimulation was also combined with a Rho inhibitor to probe their coupled effects on FN. (nature.com)
- Mechanical stimulation coupled with chemical stimulation also revealed an increase in FN fibrils around the cell periphery. (nature.com)
- These results show that mechanical stimulation directly affected FN reorganization and recruitment, despite perturbation by chemical stimulation. (nature.com)
- Though most of these studies have probed these questions through chemical stimulation, mechanical stimulation has been shown to be extremely important. (nature.com)
- Thus a thorough understanding of both mechanical and chemical stimulation separately, as well as coupled together, is integral to gain insight into FN synthesis, function and the effects of various pathology-induced abnormalities that can perturb this multi-functional protein. (nature.com)
- Mechanical stimulation is translated into intracellular signaling, which regulates the differentiation state and metabolism of chondrocytes. (elsevierpure.com)
Simulations1
- The industrial demand for increased component performance with concurrent reductions in component weight, development times and verifications using physical prototypes drives the need to use the full potential of casting and Finite Element Method (FEM) simulations to correctly predict the mechanical behavior of cast components in service. (diva-portal.org)
Abstract1
- abstract = {Investigation of the stress state in a rotating ring Is one of the basic steps In studying the bursting mechanism In different rotating machine components and tolls, for example a grinding wheel. (sv-jme.eu)
Local mechanical1
- By doing in-vivo measurements in a hydroponic system, this study investigated the responses of unimpeded roots to local mechanical stress of their neighbouring roots. (slu.se)
Compressive stress1
- An object being pushed together, such as a crumpled sponge, is subject to compressive stress and may undergo shortening. (wikipedia.org)
Department of Mechanical Engineering1
- I. The department of Mechanical Engineering offers a graduate program leading to the Master of Science degree with a major in Mechanical Engineering. (memphis.edu)
Mechanisms1
- In the present study, we completed some preliminary evaluations of the effects of adding suspension mechanisms to the mechanical arms on grinder vibrations in a simulated work task. (cdc.gov)
MEMS1
- This paper reports on a setup and a method that enables the automated analysis of mechanical stress impact on MEMS devices. (vde-verlag.de)
Electrochemical3
- We are pioneering experimental methods to measure the simultaneous electrochemical and mechanical response of electrodes," Boyd said. (tamu.edu)
- Lutkenhaus said it's important to understand how mechanical stress develops in the electrochemical state of the device. (tamu.edu)
- Herein, we report evidence of structural instabilities upon mechanical milling and electrochemical cycling of Li4FeMoO6. (amrita.edu)
Cues2
- In this context, we hypothesize that the interplay between mechanical cues (e.g. filament bending) and changes in the bacteria membrane potential play a key role to regulate bacterial filamentation. (europa.eu)
- Plants use such mechanical cues to detect e.g. herbivores, wind, neighbouring plants or to find supports to climb on. (lu.se)
Shear stress5
- When a body is subjected to two equal and opposite forces acting tangential to the resisting section than the stress induced in the body is called shear stress. (mechanicalbooster.com)
- The shear stress tries to shear off the resisting section. (mechanicalbooster.com)
- The shear stress acts tangential to the area. (mechanicalbooster.com)
- Complimentary to this, fibroblasts exposed to fluid shear stress structurally rearranged pre-coated surface FN, but unstimulated and stretched cells did not. (nature.com)
- The understanding of stress in liquids started with Newton, who provided a differential formula for friction forces (shear stress) in parallel laminar flow. (wikipedia.org)
Internal1
- Internal stresses occur when batteries develop a repeated cycling of the device, while external stresses can result from impact or penetration of the device. (tamu.edu)
Properties7
- Finally, soft magnetic material properties are determined under different mechanical load conditions and the results are presented and discussed. (jku.at)
- For the first time, phenolic formaldehyde resin (PF)-treated silica carbon black (SiCB) were prepared with different treatment conditions and their effect as fillers on the mechanical properties of filler filled natural rubber/butadiene rubber (NR/BR) composites were investigated in detail. (mdpi.com)
- As a result, both the cross-link density and mechanical properties of the obtained composites were effectively enhanced. (mdpi.com)
- The mechanical properties of copper-nickel alloys show a combination of good tensile strength and excellent ductility when annealed. (copper.org)
- Typical annealed mechanical properties for copper-nickel alloys are given in Table 1 . (copper.org)
- Minimum mechanical properties for 90-10 Cu-Ni (CW 352H) based on Euronorm Standards are outlined in Table 2 . (copper.org)
- Therefore, we investigated if storage of healing tendons in the fridge or freezer changed the mechanical properties compared to fresh tendons, using a pull-to-failure or a creep test. (lu.se)
Displacements1
- All groups presented root fractures and post displacements during mechanical cycling. (bvsalud.org)
Engineering12
- The mission of the Mechanical Engineering Technology (MET) program is to provide a world class engineering technology education that combines engineering physics and mathematics principles with materials science to design, analyze, manufacture, and maintain mechanical systems through hands on projects and active learning experiences. (shsu.edu)
- Click here to see the plan of study flow chart for the Mechanical Engineering Technology program. (shsu.edu)
- Explore other Mechanical Engineering Technology-related topics such as thermodynamics, fluid power, heat transfer, and their applications. (shsu.edu)
- Strojniški vestnik - Journal of Mechanical Engineering, 41 (1-2), 19-28. (sv-jme.eu)
- Our motorsport, automotive and mechanical engineering courses are fully accredited by the Institution of Engineering and Technology (IET) and the Institution of Mechanical Engineers (IMechE) on behalf of the Engineering Council. (brookes.ac.uk)
- Formula Student is run by the Institute for Mechanical Engineers, and is an annual student engineering competition held in the UK. (brookes.ac.uk)
- The "mechanical" in Mechanical Engineering refers to things that move. (purdue.edu)
- A more detailed description of the information listed below will be given by the Coordinator of Graduate Studies to students admitted into the Mechanical Engineering MS program. (memphis.edu)
- Upon completion of the thesis, the student must successfully pass an oral examination to assess mastery of the thesis topic and to evaluate the student's knowledge in mechanical engineering. (memphis.edu)
- Students selecting the non-thesis option must pass an oral comprehensive examination to demonstrate mastery of mechanical engineering topics commensurate with the degree to be awarded. (memphis.edu)
- Students who wish to take mechanical engineering courses must receive approval to register after consultation with the departmental graduate coordinator or with the faculty advisory committee. (memphis.edu)
- See the following link for information about the doctoral program in Mechanical Engineering. (memphis.edu)
Strength6
- What is Stress in the Strength of Materials? (mechanicalbooster.com)
- In this article, you will learn about what is stress in the strength of materials, their unit, and types of stress with numerical problems. (mechanicalbooster.com)
- This is all about what is Stress, units of stress, and types of stress in the strength of materials. (mechanicalbooster.com)
- 5. For the materials which do not exhibit a well-defined yield points, the yield strength is defined as the stress corresponding to a permanent set of how much percentage of gauge length? (sanfoundry.com)
- 6. Proof strength is defined as the stress which will produce a permanent extension of how much percentage in the gauge length of the standard test specimen. (sanfoundry.com)
- Training in a variety of rep ranges may be superior for gains in muscle size and increasing strength (better capacity for mechanical tension) and muscle endurance (better capacity for metabolic stress). (stack.com)
Mechanics1
- Working with the manager and other mechanics to diagnose and repair the mechanical and electrical components of vehicles. (simplyhired.com)
Ventilation5
- Communication Difficulties and Psychological Stress in Patients Receiving Mechanical Ventilation. (bvsalud.org)
- The Drinker and Shaw tank-type ventilator of 1929 was one of the first negative-pressure machines widely used for mechanical ventilation. (medscape.com)
- Intensive use of positive-pressure mechanical ventilation gained momentum during the polio epidemic in Scandinavia and the United States in the early 1950s. (medscape.com)
- Many factors affect the decision to begin mechanical ventilation. (medscape.com)
- Because no mode of mechanical ventilation can cure a disease process, the patient should have a correctable underlying problem that can be resolved with the support of mechanical ventilation. (medscape.com)
Demonstrate1
- Demonstrate mechanical and technical aptitude. (simplyhired.com)
Behavior3
- This instrument offers insights into measuring the mechanical behavior during an electrode's charging and discharging, which can be challenging to observe in real-time. (tamu.edu)
- This paper deals with the influence of solidification and solid state transformation on microstructure formation and the effect of local microstructure variations on the mechanical behavior of the cast component in service. (diva-portal.org)
- The results show that the FEM simulation results are significantly affected by including microstructure based mechanical behavior. (diva-portal.org)
Constraints1
- Incorporating multi-material, thermos-mechanical, stress-related objectives or constraints is crucial for producing safe and efficient designs. (anl.gov)
Significantly1
- IGF-1, col-I, and col-III were significantly increased in stressed LFCs compared to nonstressed LFCs. (hindawi.com)
Occur1
- While the primary roots did not response to a restriction in growth of the seminal roots, seminal roots reacted to the applied stress in the same way as the impeded roots, even if the stress did not occur in their environment. (slu.se)
Accurately2
- Inspect vehicle engine and mechanical/electrical components to diagnose issues accurately. (simplyhired.com)
- We found that to calculate the stresses accurately in these settings, we had to account for mechanical heterogeneities within the matrix, which we visualized and quantified using confocal reflectance and atomic force microscopy. (princeton.edu)
Differentiation2
- Mechanical stress presents a variety of effects on the metabolism and differentiation state of these cells. (elsevierpure.com)
- Sclerostin inhibits odontogenic differentiation of human pulp-derived odontoblast-like cells under mechanical stress. (bvsalud.org)
Physical5
- Mechanical stress reduces plant yield, physical disturbance of plants or plant parts. (hortomallas.com)
- 1991). Both the physical and physiological long-term effects of mechanical conditioning must be more adequately define. (hortomallas.com)
- Mathematical modeling of mechanical, electrical, pneumatic, hydraulic, and hybrid physical systems emphasizing a unified approach such as the Bond graph technique. (bradley.edu)
- Understanding how physical signals guide biological processes requires qualitative and quantitative knowledge of the mechanical forces generated and sensed by cells in a physiologically realistic three-dimensional (3D) context. (princeton.edu)
- Derived from a fundamental physical quantity (force) and a purely geometrical quantity (area), stress is also a fundamental quantity, like velocity, torque or energy, that can be quantified and analyzed without explicit consideration of the nature of the material or of its physical causes. (wikipedia.org)
Cells9
- Thus, characterizing the filamentation phenotype opens the door to understanding the physiology and adaptation of bacterial cells under stress and during colonization processes. (europa.eu)
- Mechanical stress promotes human ligamentum flavum cells (LFCs) to synthesize multitype collagens, leading to ligamentum flavum hypertrophy (LFH). (hindawi.com)
- Here we report an orthogonal mechanism of cell competition, whereby cells compete through mechanical insults. (nature.com)
- Thus, in addition to molecules, cells use mechanical means to compete. (nature.com)
- Here we show that scrib KD cells are out-competed by wild-type cells through mechanical insults rather than molecular exchange. (nature.com)
- We find that scrib KD cells are hypersensitive to compaction and that this is due to elevation of baseline p53 levels, which is both necessary and sufficient to induce hypersensitivity to crowding and confer a mechanical loser status. (nature.com)
- Overall, this work demonstrates that mechanical forces can be responsible for the elimination of cells during cell competition and that p53 levels play a key role both in instructing the mechanical loser status and in the execution of mechanical cell competition. (nature.com)
- In this work, we employed two different strategies to mechanically stress cancer cells. (unicz.it)
- Moreover, Raman spectroscopy analysis, after mechanical treatment, in the range between 700-1800 cm-1, indicated a relative concentration variation of MHC class I. PCA analysis was also performed to distinguish control and stressed cells within different cell lines. (unicz.it)
Pneumatic1
- Hand-transmitted vibrations of pneumatic grinders suspended from a mechanical arm system. (cdc.gov)
Parameters2
- This work is about the improved characterization of soft magnetic sheet materials including the evaluation of electromagnetic material parameters and iron loss models under mechanical stress. (jku.at)
- The effect of mechanical stresses generated by an extreme agitation intensity or a high aeration rate on growth parameters and cell physiology were studied during continuous cultivation of the Gram-positive bacterium Corynebacterium glutamicum. (birmingham.ac.uk)
Affects1
- Mechanical conditioning usually affects plant growth only during the period of treatment. (hortomallas.com)
Response7
- One of the characteristic bacteria phenotypes of antibiotic resistance (and more generally of a stress response) is filamentation, which has been linked to survival strategies and virulence and is present in the most common form of bacteria in nature: biofilms. (europa.eu)
- 1975). However, only recently has plant response to mechanical stress been studied to control plant. (hortomallas.com)
- These differences in yield response to mechanical stress again may be due to differences in cultivars or species. (hortomallas.com)
- To analyze the mechanobiological response, we have been developing mechanical stress culture device. (elsevierpure.com)
- Mechanical stress on the joints, such as occurs in movement, may result in an excessive inflammatory response in people with psoriatic arthritis. (medlineplus.gov)
- it changes your stress response system, your sort of 'fight or flight' type of response, and it also changes your sympathetic nervous system," said Dr Tietjen. (medscape.com)
- The plant response to biotic and abiotic stress has been studied for many years, but the molecular mechanism controlling touch-signalling in plants is not well understood. (lu.se)
Tissue2
- Furthermore, tissue geometry defines the spatial distribution of mechanical stress across the epithelium, which communicates mechanically over distances spanning hundreds of micrometers. (princeton.edu)
- Tissue force and stress were unaltered by storage and preconditioning compared to fresh samples, while high preconditioning increased the stiffness and modulus (p ≤ 0.007). (lu.se)
Fluid1
- Chamsart, S, Hewitt, C & Nienow, A 2005, ' The impact of fluid mechanical stress on Corynebacterium glutamicum during continuous cultivation in an agitated bioreactor ', Biotechnology Letters , vol. 27, pp. 693-700. (birmingham.ac.uk)
Fractures1
- A form of stress fractures that result when normal force is applied to bones with deficient elasticity. (bvsalud.org)
Yield1
- The Mechanical stress reduces plant yield applied naturally or under controlled conditions. (hortomallas.com)
Analysis1
- We are currently working alongside one of the globes largest and most prestigous manufacturing businesses, to help them find a number of experienced Mechanical Engineers on a contract basis helping with the analysis of some of the businesses main product range. (jobmove.com)
Calculate1
- Supposed we have given a bar of cross section area 20 mm 2 and it subjected to a tensile load of 60 N. then calculate the stress induced in the body. (mechanicalbooster.com)
Developmental1
- The complete integumentary organ system (IOS) regeneration and scarless wound healing mechanism, which occurs in specific species, body sites and developmental stages, clearly shows that mechanical stress signals and immune responses play important roles in determining the wound healing mode. (mdpi.com)
Perform1
- What kind of mechanical stress testing does Nemko perform? (nemko.com)
Results2
- In summary, these results suggested that mechanical stress promotes LFCs to produce IGF-1, which facilitates col-I and col-III synthesis via the IGF-1R/AKT/mTORC1 signaling pathway. (hindawi.com)
- These results indicate that balsam fir trees respond to mechanical stress caused by shaking and/or baling, by a decline in water uptake, increase in ethylene and VTCs specifically, 3-carene, β-pinene and β-terpene leading to postharvest needle abscission, which was modulated by storage of trees at low temperature (3oC) and low VPD (0.26 kPa). (dal.ca)
Affect1
- Pinching or pruning stems, deadheading flowers, bagging potted plants or training branches , are mechanical stresses that affect plant growth . (hortomallas.com)
Geometry1
- Ancient and medieval architects did develop some geometrical methods and simple formulas to compute the proper sizes of pillars and beams, but the scientific understanding of stress became possible only after the necessary tools were invented in the 17th and 18th centuries: Galileo Galilei's rigorous experimental method, René Descartes's coordinates and analytic geometry, and Newton's laws of motion and equilibrium and calculus of infinitesimals. (wikipedia.org)
Optimization1
- The focus is on the design and the optimization of the test setup for impressing mechanical stress conditions like tensile, compressive, and shear stresses, to soft magnetic sheet materials for two-dimensional electromagnetic measurements. (jku.at)
Tension2
Significant1
- Two Reports of Investigations provide detailed findings on ground stress redistribution resulting from mining, which could ultimately lead to significant improvements in the stability of mine excavations and ensure a safer working environment for miners. (cdc.gov)