Stomatognathic System: The mouth, teeth, jaws, pharynx, and related structures as they relate to mastication, deglutition, and speech.Stomatognathic Diseases: General or unspecified diseases of the stomatognathic system, comprising the mouth, teeth, jaws, and pharynx.Stomatognathic System Abnormalities: Congenital structural abnormalities of the mouth and jaws, including the dentition.Temporomandibular Joint Disorders: A variety of conditions affecting the anatomic and functional characteristics of the temporomandibular joint. Factors contributing to the complexity of temporomandibular diseases are its relation to dentition and mastication and the symptomatic effects in other areas which account for referred pain to the joint and the difficulties in applying traditional diagnostic procedures to temporomandibular joint pathology where tissue is rarely obtained and x-rays are often inadequate or nonspecific. Common diseases are developmental abnormalities, trauma, subluxation, luxation, arthritis, and neoplasia. (From Thoma's Oral Pathology, 6th ed, pp577-600)Dental Occlusion, Traumatic: An occlusion resulting in overstrain and injury to teeth, periodontal tissue, or other oral structures.Trigeminal Nerve Diseases: Diseases of the trigeminal nerve or its nuclei, which are located in the pons and medulla. The nerve is composed of three divisions: ophthalmic, maxillary, and mandibular, which provide sensory innervation to structures of the face, sinuses, and portions of the cranial vault. The mandibular nerve also innervates muscles of mastication. Clinical features include loss of facial and intra-oral sensation and weakness of jaw closure. Common conditions affecting the nerve include brain stem ischemia, INFRATENTORIAL NEOPLASMS, and TRIGEMINAL NEURALGIA.Masticatory Muscles: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)Facial Pain: Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.Masseter Muscle: A masticatory muscle whose action is closing the jaws.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.

*  Partial Pulpotomy on Caries Free Human Teeth - Full Text View - ClinicalTrials.gov

Dental Pulp Diseases. Tooth Diseases. Stomatognathic Diseases. ClinicalTrials.gov processed this record on September 20, 2017. ...
https://clinicaltrials.gov/ct2/show/NCT01420718

*  Mandibular Overdentures Retained by Conventional or Mini Implants - Full Text View - ClinicalTrials.gov

Mouth Diseases. Stomatognathic Diseases. Tooth Diseases. Jaw Diseases. Musculoskeletal Diseases. To Top ...
https://clinicaltrials.gov/ct2/show/NCT01411683?recr=Open&cond="Jaw"&rank=1

*  Benzydamine HCl for Postoperative Sore Throat - Full Text View - ClinicalTrials.gov

Stomatognathic Diseases. Respiratory Tract Infections. Respiratory Tract Diseases. Otorhinolaryngologic Diseases. Benzydamine. ...
https://clinicaltrials.gov/ct2/show/NCT01637883?recr=Open&cond="Pharyngitis"&rank=11

*  Using Combination of Synthetic Bone Substitutes During Extractions - Full Text View - ClinicalTrials.gov

Periodontal Diseases. Mouth Diseases. Stomatognathic Diseases. Tooth Demineralization. Tooth Diseases. Bone Resorption. Bone ... Musculoskeletal Diseases. Periodontal Atrophy. Calcium, Dietary. Bone Density Conservation Agents. Physiological Effects of ...
https://clinicaltrials.gov/ct2/show/NCT01503593?recr=Open&intr=dietary calcium&rank=15

*  A Clinical Study to Compare Two Revascularization Protocols to Treat Non-vital Teeth With Incomplete Root Formation - Full Text...

Healthy or having a mild systemic disease (ASA Physical Status 1 or 2), with no contraindications to the treatment. ...
https://clinicaltrials.gov/ct2/show/NCT01827098?recr=Open&intr=root canal&rank=20

*  Study on the Carcinogenesis of Gα12 in Oral Cancer, and the Treatment of Oral Cancer Using Ga12 Inhibitor. - Full Text View -...

Mouth Diseases. Stomatognathic Diseases. Lip Diseases. Neoplastic Processes. Pathologic Processes. ClinicalTrials.gov processed ... Genetic and Rare Diseases Information Center resources: Oral Cancer Lip and Oral Cavity Cancer ... In the case the disease recurs after the surgery, subjects need to receive the surgery again and take another blood exam before ... In the case the disease recurs after the surgery, subjects need to receive the surgery again and take another blood exam before ...
https://clinicaltrials.gov/ct2/show/NCT01919580?recr=Open&cond="Mouth Neoplasms"&rank=1

*  Furlow Palatoplasty With Tensor Tenopexy - Full Text View - ClinicalTrials.gov

Stomatognathic Diseases. Mouth Abnormalities. Mouth Diseases. Stomatognathic System Abnormalities. Congenital Abnormalities. ... Ear Diseases. Otorhinolaryngologic Diseases. Jaw Abnormalities. Jaw Diseases. Musculoskeletal Diseases. Maxillofacial ... However, the disease often returns when the plastic tube becomes blocked or falls out and a new tube needs to be placed in the ... Almost all infants and young children who were born with a cleft palate (with or without a cleft lip) have middle-ear disease ...
https://clinicaltrials.gov/ct2/show/NCT01535131?term=Alpers

*  The Children's Amalgam Trial - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. ClinicalTrials.gov processed this record on September 20, 2017. ...
https://clinicaltrials.gov/ct2/show/NCT00065988

*  S0225 Capecitabine in Treating Patients Who Have Undergone Surgery for Locally Recurrent or Persistent Head and Neck Cancer -...

Stomatognathic Diseases. Otorhinolaryngologic Diseases. Nose Diseases. Respiratory Tract Diseases. Paranasal Sinus Diseases. ... All current disease must be completely resected, including resection of recurrent primary disease and/or neck dissection, if ... Determine 2-year disease-free survival of patients treated with surgical salvage followed by adjuvant low-dose capecitabine for ... No evidence of distant disease by clinical examination and CT scan of the chest and upper abdomen (including the liver) within ...
https://clinicaltrials.gov/ct2/show/NCT00095641?cond="Nose Neoplasms"&rank=19

*  Efficacy of a Propolis-based Denture Cleanser - Full Text View - ClinicalTrials.gov

Mouth Diseases. Stomatognathic Diseases. Dental Deposits. Tooth Diseases. Pharmaceutical Solutions. Propolis. Anti-Infective ...
https://clinicaltrials.gov/show/NCT01237782

*  Radiographic Progression of Sealed and Infiltrated Caries Lesions in Vivo - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. ClinicalTrials.gov processed this record on September 21, 2017. ...
https://clinicaltrials.gov/show/NCT01417832

*  Intensity-Modulated Radiation Therapy or 3-Dimensional Conformal Radiation Therapy in Decreasing Hearing Loss in Patients Who...

... social and emotional well-being including generic functional and symptom aspects as well as disease-specific issues relevant to ... 65 Gy if macroscopic residual disease). Patients may undergo elective neck irradiation of the uninvolved lymph node areas once ... 65 Gy if macroscopic residual disease). Patients may undergo elective neck irradiation of the uninvolved lymph node areas once ...
https://clinicaltrials.gov/ct2/show/NCT01216800?recr=Open&cond="Mouth Diseases"&rank=8

*  Predicting Caries Risk in Underserved Toddlers in Primary Healthcare Settings - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. To Top. *For Patients and Families. *For Researchers ...
https://clinicaltrials.gov/ct2/show/NCT01707797?recr=Open&intr="Dental Care"&rank=11

*  Tooth Smart Healthy Start: Oral Health Advocates in Public Housing - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. ClinicalTrials.gov processed this record on September 18, 2017. ... Dental caries is the most common chronic disease of childhood and is increasing in prevalence in children 2-5 years old. Racial ... subject child has a known systemic disease associated with abnormal tooth development or abnormal oral health status such as ... Dental caries is the most common, chronic disease of childhood, is increasing in prevalence, and disproportionately affects ...
https://clinicaltrials.gov/ct2/show/NCT01205971?recr=Open&intr="Oral Health"&rank=6

*  Training and Calibration of Dental Examiners - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. Fluorides. Chlorhexidine. Chlorhexidine gluconate. Triclosan. Cariostatic Agents. ... Other disease of the hard or soft oral tissues.. *Impaired salivary function (e.g. Sjogren's syndrome or head and neck ... Moderate or advanced periodontal disease or heavy dental tartar (calculus).. *2 or more decayed untreated dental sites at ...
https://clinicaltrials.gov/ct2/show/NCT00765167

*  Ascorbic Acid Treatment in CMT1A Trial (AATIC) - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. Nervous System Malformations. Nervous System Diseases. Heredodegenerative Disorders, ... Peripheral Nervous System Diseases. Neuromuscular Diseases. Congenital Abnormalities. Genetic Diseases, Inborn. Vitamins. ... Genetic and Rare Diseases Information Center resources: Charcot-Marie-Tooth Disease Hereditary Neuropathy With Liability to ... In childhood, disease progression has been shown. In adults, there are indications for disease progression, but properly ...
https://clinicaltrials.gov/ct2/show/NCT00271635?cond="Charcot-Marie-Tooth Disease"&rank=2

*  Tooth Smart Healthy Start: Oral Health Advocates in Public Housing - Full Text View - ClinicalTrials.gov

Dental caries is the most common chronic disease of childhood and is increasing in prevalence in children 2-5 years old. Racial ... subject child has a known systemic disease associated with abnormal tooth development or abnormal oral health status such as ... Dental caries is the most common, chronic disease of childhood, is increasing in prevalence, and disproportionately affects ...
https://clinicaltrials.gov/ct2/show/NCT01205971?recr=Open&intr="Dental Care"&rank=6

*  The Effect of Ultrasound on Orthodontic Tooth Movement - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. To Top. *For Patients and Families. *For Researchers ...
https://clinicaltrials.gov/ct2/show/NCT01828164?term=orthodontic&recr=Open&rank=15

*  The Relation Between Pregnancy,Birth Outcome, Feeding , Oral Hygiene Habits and Early Childhood Caries Development. - Full Text...

Tooth Diseases. Stomatognathic Diseases. ClinicalTrials.gov processed this record on September 21, 2017. ...
https://clinicaltrials.gov/ct2/show/NCT00334087?recr=Open&cond="Dental Caries"&rank=8

*  Polarized Reflectance Spectroscopy for Oral Lesions - Full Text View - ClinicalTrials.gov

Genetic and Rare Diseases Information Center resources: Oral Cancer Lip and Oral Cavity Cancer ...
https://clinicaltrials.gov/ct2/show/NCT01604759?recr=Open&cond="Mouth Diseases"&rank=8

*  Periodontal Ligament Stress Level and Tooth Movement - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. Jaw Abnormalities. Jaw Diseases. Musculoskeletal Diseases. Mandibular Diseases. ...
https://clinicaltrials.gov/ct2/show/NCT00099814

*  Study on OsseoSpeed™ Implants Replacing 2-5 Teeth in the Posterior Upper Jaw, Restored With Provisional Teeth Attached 6-7...

Mouth Diseases. Stomatognathic Diseases. Tooth Diseases. Jaw Diseases. Musculoskeletal Diseases. To Top ... Untreated caries and/or periodontal disease of residual dentition. *History of edentulism in the area of implant placement of ... Any systemic or local disease or condition that would compromise post-operative healing and/or osseointegration ...
https://clinicaltrials.gov/ct2/show/NCT00711113

*  Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair - Full Text View - ClinicalTrials...

Stomatognathic Diseases. Mouth Abnormalities. Mouth Diseases. Stomatognathic System Abnormalities. Congenital Abnormalities. ... Jaw Diseases. Musculoskeletal Diseases. Maxillofacial Abnormalities. Craniofacial Abnormalities. Musculoskeletal Abnormalities ...
https://clinicaltrials.gov/ct2/show/NCT01500109?recr=Open&cond="Cleft Palate"&rank=3

*  Impact of the Radiographic Examination on Diagnosis and Treatment Decision of Caries Lesions in Primary Teeth - Full Text View ...

Tooth Diseases. Stomatognathic Diseases. Periodontal Diseases. Mouth Diseases. ClinicalTrials.gov processed this record on ...
https://clinicaltrials.gov/ct2/show/NCT02078453?term=dental [CONDITION] AND child [AGE-GROUP]&recr=Open&rank=16

*  Efficacy and the Safety Study of RD94 in Patients With Endodontic Care - Full Text View - ClinicalTrials.gov

Tooth Diseases. Stomatognathic Diseases. Wounds and Injuries. ClinicalTrials.gov processed this record on September 21, 2017. ... Systemic disease not stabilized within 1 month before the Inclusion Visit or judged by the investigator to be incompatible with ... Molar presenting deep carious lesion without irreversible pulpal disease, as the molar has to stay on the dental arch for at ... Molar presenting deep carious lesion without irreversible pulpal disease, as the molar has to stay on the dental arch for at ...
https://clinicaltrials.gov/ct2/show/NCT01737229

(1/58) The impact of molecular genetics on oral health paradigms.

As a result of our increased understanding of the human genome, and the functional interrelationships of gene products with each other and with the environment, it is becoming increasingly evident that many human diseases are influenced by heritable alterations in the structure or function of genes. Significant advances in research methods and newly emerging partnerships between private and public sector interests are creating new possibilities for utilization of genetic information for the diagnosis and treatment of human diseases. The availability and application of genetic information to the understanding of normal and abnormal human growth and development are fundamentally changing the way we approach the study of human diseases. As a result, the issues and principles of medical genetics are coming to bear across all disciplines of health care. In this review, we discuss some of the potential applications of human molecular genetics for the diagnosis and treatment of oral diseases. This discussion is presented in the context of the ongoing technological advances and conceptual changes that are occurring in the field of medical genetics. To realize the promise of this new molecular genetics, we must be prepared to foresee the possibilities and to incorporate these newly emergent technologies into the evolving discipline of dentistry. By using examples of human conditions, we illustrate the broad application of this emerging technology to the study of simple as well as complex genetic diseases. Throughout this paper, we will use the following terminology: Penetrance--In a population, defined as the proportion of individuals possessing a disease-causing genotype who express the disease phenotype. When this proportion is less than 100%, the disease is said to have reduced or incomplete penetrance. Polymerase chain reaction (PCR)--A technique for amplifying a large number of copies of a specific DNA sequence flanked by two oligonucleotide primers. The DNA is alternately heated and cooled in the presence of DNA polymerase and free nucleotides, so that the specified DNA segment is denatured, hybridized with primers, and extended by DNA polymerase. MIM--Mendelian Inheritance in Man catalogue number from V. McKusick's Mendelian Inheritance in man (OMIM, 1998).  (+info)

(2/58) Dental health and viridans streptococcal bacteremia in allogeneic hematopoietic stem cell transplant recipients.

Viridans streptococci were the most common cause of bacteremia in 61 consecutive myeloablative allogeneic hematopoietic stem cell transplant (HSCT) recipients, occurring in 19 of 31 bacteremic patients (61%) during the period of post-transplant neutropenia. Seven of the 19 had more than one viridans streptococcus in the same blood culture. Twenty isolates from 15 patients were Streptococcus mitis. Most viridans streptococci were resistant to norfloxacin, used routinely for prophylaxis. Comparison of the 19 patients with viridans streptococcal bacteremia with a contemporaneous group of 23 allogeneic HSCT recipients with fever and neutropenia but no identified focus of infection found that patients with viridans streptococcal bacteremia were more likely to have severe intraoral pathology while neutropenic (26% vs 0%) and slightly shorter interval between the last dental procedure and the onset of neutropenia (11 vs 14 days). Poor underlying dental health and the use of norfloxacin thus appear to predispose to viridans streptococcal bacteremia.  (+info)

(3/58) Diagnostic codes in dentistry--definition, utility and developments to date.

Diagnostic codes are computer-readable descriptors of patients' conditions contained in computerized patient records. The codes uniquely identify the diagnoses or conditions identified at initial or follow-up examinations that are otherwise written in English or French on the patient chart. Dental diagnostic codes would allow dentists to access information on the types and range of conditions they encounter in their practices, enhance patient communication, track clinical outcomes and monitor best practices. For the profession, system-wide use of the codes could provide information helpful in understanding the oral health of Canadians, demonstrate improvements in oral health, track best practices system-wide, and identify and monitor the progress of high-need groups in Canada. Different systems of diagnostic codes have been implemented by program managers in Germany, the United Kingdom and North America. In Toronto, the former North York Community Dental Services developed and implemented a system that follows the logic used by the Canadian Dental Association for its procedure codes. The American Dental Association is now preparing for the release of SNODENT codes. The addition of diagnostic codes to the service codes already contained in computerized patient records could allow easier analysis of the rich evidence available on the oral health and oral health care of Canadians, thereby enhancing our ability to continuously improve patient care.  (+info)

(4/58) Oral manifestations of Albright hereditary osteodystrophy: a case report.

Albright hereditary osteodystrophy is a hereditary metabolic disorder of dominant autosomal etiology that is commonly characterized by short stature, round face, small metacarpus and metatarsus, mental retardation, osteoporosis, subcutaneous calcification, variable hypocalcemia, and hyperphosphatemia. In this study, we report a clinical case of a 17-year-old woman with Albright hereditary osteodystrophy, and we discuss her clinical, radiographic, and laboratory test characteristics together with the oral manifestations, and we correlate them with the characteristics found in the literature. We also discuss the odontological management of treatment of related periodontal disease and planning for corrections of related malocclusions.  (+info)

(5/58) Costs of medically treated craniofacial conditions.

OBJECTIVES: Determining the magnitude of the burden of diseases and health disorders on the U.S. population is a high priority for health policy makers. Conditions such as malignant neoplasms and injuries from craniofacial trauma contribute to adverse oral health. This study estimates the number of cases of diseases and disorders relevant to oral health that are treated annually in the medical care, as opposed to the dental care, system and associated costs. Policy makers can use this cost model to compare the impact of different conditions, to target areas for reducing costs, and to allocate appropriate health resources. METHODS: Data from four national and two state data systems were used to estimate the number of cases of selected dental, oral, and craniofacial diseases and conditions treated in the medical system annually and associated medical and wage/household work loss costs. RESULTS: Per case, the most costly conditions were estimated to be malignant neoplasms at 83,080 US dollars annually (in 1999 dollars), diabetes-related oral conditions at 51,030 US dollars, endocarditis at 48,610 US dollars, and chlamydiae at 41,100 US dollars. Total estimated costs for oral conditions treated in the medical care system in 1996 were approximately 95.9 billion US dollars, including 21.4 billion US dollars in medical costs and 74.4 US dollars billion in wage/household work loss costs. CONCLUSIONS: Conditions treated outside the dental care system are major contributors to oral health costs. They should be an important focus for the National Institute of Dental and Craniofacial Research.  (+info)

(6/58) Taxonomy for competency-based dental curricula.

The objective of this article is to propose a classification of dental competencies. Interest in dental competencies has grown consistently during the last three decades. However, the dental education literature suggests that the term "competency" is understood and used differently by dental schools around the world. The taxonomic classification of dental competencies we propose follows a systematic approach starting at the highest level of complexity, i.e., the professional profile the teaching institution envisions for its graduates, and following in a decreasing degree of complexity to competency function, task, step, movement, and moment. This taxonomy has proved to be useful for more than thirty years in the Dental School of the Peruvian University Cayetano Heredia. Graduates of this school are successful practitioners, teachers, and researchers in Peru and other countries. The classification proposed here should clarify terms, facilitate curriculum design and learning assessment, stimulate further discussion on the matter, and facilitate communication among the dental education establishment.  (+info)

(7/58) A case of soft tissue myoepithelial tumor arising in masticator space.

Soft tissue myoepithelial tumors of the head and neck region are very rare, and only one case of soft tissue myoepithelial tumor occurring in the masticator space has been reported in the world literature. A case of soft tissue myoepithelial tumor with benign histomorphology, but with an invasive growth pattern, occurred in the masticator space of a 46-year- old male patient. Magnetic resonance imaging of paranasal sinus/nasopharynx revealed a well-defined, lobulated heterogeneous mass with high signal intensity and dense calcification in the masticator space between the left mandible ramus and pterygoid process. Grossly, the tumor was a well- circumscribed ovoid solid mass and consisted of yellowish gray glistening firm tissue. Histologically, the tumor showed a multinodular growth pattern and consisted of epithelioid cells in chondromyxoid stroma and of spindle-shaped to ovoid cells in the hyaline stroma. The tumor cells appeared bland, and no mitosis or necrosis was found within the tumor. The tumor focally invaded to adhered bone tissue. Immunohistochemically, the tumor cells were diffusely positive for epithelial membrane antigen, smooth muscle actin, but negative for other epithelial markers. Ultrastructurally, the cytoplasm of the tumor cells contained sparse microfilaments and subplasmalemmal densities. Attenuated desmosomes were commonly seen between the tumor cells.  (+info)

(8/58) Incontinentia pigmenti: clinical observation of 40 Korean cases.

Incontinentia pigmenti (IP) is an uncommon genodermatosis that usually occurs in female infants. It is characterized by ectodermal, mesodermal, neurological, ocular, and dental manifestations. The aim of this study was to clarify clinical symptoms, accompanying diseases, and complications of IP. Forty cases of IP have been reviewed by their medical records, laboratory data, clinical photographs, and telephone survey. Male-to-female ratio was 1 to 19 and their onsets were mostly in utero. They were usually diagnosed during the neonatal period owing to their early expression of skin manifestation. Central nervous system anomalies were found in 46.7%. Ocular disorders and dental defects were detected in 66.7% and 72.7% respectively. The most commonly diagnosed anomalies were hypodontia, retinopathy, and seizure. For better understanding of IP, long term and close cooperation between dermatologists, pediatricians, neuroscientists, genetic counselors, and even dentists is crucial.  (+info)



progression


  • Patients receive oral capecitabine once daily for 12 months in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
  • In childhood, disease progression has been shown. (clinicaltrials.gov)
  • In adults, there are indications for disease progression, but properly conducted longitudinal studies are awaited. (clinicaltrials.gov)

childhood


  • Almost all infants and young children who were born with a cleft palate (with or without a cleft lip) have middle-ear disease and this condition can last into late childhood and early adolescence. (clinicaltrials.gov)
  • Dental caries is the most common chronic disease of childhood and is increasing in prevalence in children 2-5 years old. (clinicaltrials.gov)
  • Dental caries is the most common, chronic disease of childhood, is increasing in prevalence, and disproportionately affects individuals who are financially disadvantaged and from racial and ethnic minority groups. (clinicaltrials.gov)

relevant


  • To describe and compare the impact of both IMRT and conventional radiotherapy on physical, social and emotional well-being including generic functional and symptom aspects as well as disease-specific issues relevant to audiometry. (clinicaltrials.gov)

Dental


  • Moderate or advanced periodontal disease or heavy dental tartar (calculus). (clinicaltrials.gov)

patients


  • This study compares a standard method for palate repair (the Furlow palatoplasty) with a modification of that method to determine which, if either, is more effective in reducing the duration of middle-ear disease (fluid in the ear) in cleft palate patients. (clinicaltrials.gov)
  • The type of middle-ear disease that usually occurs in cleft palate patients is not associated with pain or symptoms, but the fluid in the middle-ear causes poor hearing and sometimes problems with balance. (clinicaltrials.gov)
  • Determine patterns of disease relapse in patients treated with this drug. (clinicaltrials.gov)
  • Arm I (cochlear-sparing intensity-modulated radiotherapy [IMRT]): Patients undergo cochlear-sparing IMRT using the local planning system once daily, 5 days per week, for 6 weeks (total of 30 fractions) at a total dose of 60 Gy (65 Gy if macroscopic residual disease). (clinicaltrials.gov)
  • Cross-sectional studies show that disease severity in adults is variable: a group of CMT1A patients is asymptomatic (5-10%), whereas other patients are wheelchair dependent (5-10%), still most have the classical CMT phenotype. (clinicaltrials.gov)

often


  • However, the disease often returns when the plastic tube becomes blocked or falls out and a new tube needs to be placed in the eardrum. (clinicaltrials.gov)
  • Charcot-Marie-Tooth type 1A (CMT1A), or hereditary motor and sensory neuropathy type Ia (HMSN Ia), is an autosomal dominant disease, most often caused by a 1.5 Mb duplication of chromosome 17, giving rise to three copies of the peripheral myelin protein 22 gene (PMP22). (clinicaltrials.gov)

show


  • Past studies show that the middle-ear disease in infants and children with cleft palate is caused by their inability to open a natural tube that connects the back of the nose with the middle-ear (called the Eustachian tube). (clinicaltrials.gov)

months


  • In the case the disease recurs after the surgery, subjects need to receive the surgery again and take another blood exam before the surgery and 3 months after the surgery. (clinicaltrials.gov)

treatment


  • Healthy or having a mild systemic disease (ASA Physical Status 1 or 2), with no contraindications to the treatment. (clinicaltrials.gov)