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Medical search (Stevens-Johnson Syndrome • Web)


Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.HLA-B15 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.Conjunctival DiseasesCarbamazepine: An anticonvulsant used to control grand mal and psychomotor or focal seizures. Its mode of action is not fully understood, but some of its actions resemble those of PHENYTOIN; although there is little chemical resemblance between the two compounds, their three-dimensional structure is similar.Erythema Multiforme: A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic "bull's-eye" lesions usually occurring on the dorsal aspect of the hands and forearms.Chlormezanone: A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.ConjunctivitisAllopurinol: A XANTHINE OXIDASE inhibitor that decreases URIC ACID production. It also acts as an antimetabolite on some simpler organisms.Eye Diseases: Diseases affecting the eye.Anticonvulsants: Drugs used to prevent SEIZURES or reduce their severity.HLA-B Antigens: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.Oral Ulcer: A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)Dysuria: Painful URINATION. It is often associated with infections of the lower URINARY TRACT.Corneal Diseases: Diseases of the cornea.Pneumonia, Mycoplasma: Interstitial pneumonia caused by extensive infection of the lungs (LUNG) and BRONCHI, particularly the lower lobes of the lungs, by MYCOPLASMA PNEUMONIAE in humans. In SHEEP, it is caused by MYCOPLASMA OVIPNEUMONIAE. In CATTLE, it may be caused by MYCOPLASMA DISPAR.Amnion: The innermost membranous sac that surrounds and protects the developing embryo which is bathed in the AMNIOTIC FLUID. Amnion cells are secretory EPITHELIAL CELLS and contribute to the amniotic fluid.Syndrome: A characteristic symptom complex.Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.Eye Burns: Injury to any part of the eye by extreme heat, chemical agents, or ultraviolet radiation.Conjunctiva: The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

*  2017/18 ICD-10-CM Diagnosis Code L51.3: Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome

Stevens-Johnson syndrome-toxic epidermal necrolysis overlap syndrome. 2016 2017 2018 Billable/Specific Code *L51.3 is a ... Stevens-johnson syndrome - toxic epidermal necrolysis overlap. ICD-10-CM L51.3 is grouped within Diagnostic Related Group(s) ( ... Short description: Stevens-Johnson synd-tox epdrml necrolysis overlap syndrome. *The 2018 edition of ICD-10-CM L51.3 became ... Stevens johnson syndrome, toxic epidermal necrolysis overlap. * ... Stevens-Johnson syndrome (L51.1). *Stevens-Johnson syndrome- ...

*  Complex wound and skin conditions | Shriners Hospitals for Children - Galveston

Stevens-Johnson syndrome (SJS). Stevens-Johnson syndrome (erythema multiforme major) is a serious disorder affecting the skin ... This syndrome usually begins with flu-like symptoms, followed by a painful red or purplish rash that spreads and blisters, ...

*  Arava (Leflunomide): Side Effects, Interactions, Warning, Dosage & Uses

Stevens-Johnson syndrome and toxic epidermal necrolysis [see WARNINGS AND PRECAUTIONS]. *Peripheral neuropathy [see WARNINGS ... Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis, And Drug Reactions With Eosinophilia And Systemic Symptoms. Rare cases of ... Skin and Appendages: erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, vasculitis including cutaneous ... Steven Johnson Syndrome, toxic epidermal necrolysis, peripheral neuropathy, interstitial lung disease), suspected ...

*  Dr. Jeffrey Frederic, MD - Baton Rouge, LA - Dermatology | Healthgrades.com

Stevens-Johnson Syndrome. *Tinea Versicolor. *Ulcer. *Varicose Veins. *Warts. More. 9. Procedures. *Abscess or Cyst Drainage or ...

*  General Terms | Adult and Adolescent ARV | AIDSinfo

Stevens-Johnson syndrome. SSRI. selective serotonin reuptake inhibitor. STI. sexually transmitted infection. ...

*  Pravastatin Sodium (Professional Patient Advice) - Drugs.com

... including Stevens-Johnson syndrome.. Precautions. Monitor. Myopathy Monitor patient for symptoms of myopathy (muscle pain, ... An apparent hypersensitivity syndrome has been reported rarely that has included 1 or more of the following features: ... anaphylaxis; angioedema; lupus erythematous-like syndrome; polymyalgia rheumatica; vasculitis; purpura; thrombocytopenia; ...

*  Browse EE Topics - Essential Evidence Plus

Stevens-Johnson syndrome Essential Evidence Topics, 28-Mar-2017 Overall Bottom Line: If patient presents with prodromal febrile ... Stevens-Johnson syndrome should be expected. Start supportive treatment and consider transfer to a burn ... Staphylococcal scalded skin syndrome Essential Evidence Topics, 9-Jul-2017 Overall Bottom Line: Staphylococcal scalded skin ... Overall Bottom Line: A diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS) should be considered for any complaint of ...

*  Ceftin (Cefuroxime Axetil): Side Effects, Interactions, Warning, Dosage & Uses

Angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.. DRUG INTERACTIONS. Oral ...

*  Urinary tract infection with Doxycycline

Stevens-johnson Syndrome (35). Suicidal Ideation (34). Muscle Spasms (32). Confusional State (32). ... Chronic Bladder Pain Syndrome in Women: Can Doxycycline. Help? A Prospective Study Conditions: Chronic Pelvic Pain Syndrome; ... in Women With Polycystic Ovarian Syndrome Conditions: Polycystic Ovarian Syndrome (PCOS); Irregular Menstrual Cycles; Androgen ...

*  Tekturna: Indications, Side Effects, Warnings - Drugs.com

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health ...

*  Omeprazole+Syrspend SF Alka Information - Drugs.com

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health ... It is used to treat syndromes caused by lots of stomach acid. ...

*  Vigabatrin - FDA prescribing information, side effects and uses

Skin and Subcutaneous Tissue Disorders: Angioedema, maculo-papular rash, pruritus, Stevens-Johnson syndrome (SJS), toxic ... fetal anticonvulsant syndrome, hamartomas, hip dysplasia, limb malformation, limb reduction defect, low set ears, renal aplasia ...

*  Hyoscyamine, Atropine, Scopolamine, Phenobarbital Controlled-Release Tabs - Drugs.com

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health ... Irritable Bowel Syndrome dicyclomine, Amitiza, Bentyl, Metamucil, psyllium, hyoscyamine, Levsin, Librax, More... ...

*  Acyclovir Capsules - FDA prescribing information, side effects and uses

Skin: Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis ... Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), which has resulted in death, has occurred in ...

*  METOJECT PEN 25 MG SOLUTION FOR INJECTION IN PRE-FILLED PEN | Drugs.com

be signs of conditions called Stevens Johnson syndrome. or burned skin syndrome (toxic epidermal necrolysis/. Lyell's syndrome ... HIV or other immunodeficiency syndromes.. • suffer from mouth ulcers, stomach ulcer or intestinal ulcer.. • are pregnant or ...

*  Alogliptin and pioglitazone Advanced Patient Information - Drugs.com

Stevens-Johnson syndrome). These reactions can be life-threatening and require immediate medical attention. Call your doctor ...

*  Didronel IV Side Effects in Detail - Drugs.com

Frequency not reported: Angioedema, follicular eruption, macular rash, maculopapular rash, pruritus, Stevens-Johnson syndrome, ... 1. Saunders RL, Jr "Appearance of a gastric ulcer during diphosphonate therapy in a woman with CRST syndrome." South Med J 70 ( ...

*  Amoxicillin/clavulanate Side Effects in Detail - Drugs.com

Stevens-Johnson syndrome, and exfoliative dermatitis. Amoxicillin rashes occur more frequently in patients with unrecognized ... Stevens-Johnson syndrome (rarely), acute generalized exanthematous pustulosis, hypersensitivity vasculitis, exfoliative ... clavulanate-associated hepatic failure with progression to Stevens-Johnson syndrome." Ann Pharmacother 33 (1999): 560-4 ... Iravani A, Richard GA, Johnson D, Bryant A "A double-blind, multicenter, comparative study of the safety and efficacy of ...

*  Nivolumab in Eliminating Minimal Residual Disease and Preventing Relapse in Patients With Acute Myeloid Leukemia in Remission...

Stevens-Johnson syndrome, or phospholipid syndrome should be excluded; patients with vitiligo, endocrine deficiencies including ... Total bilirubin =, 1.5 x institutional upper limit of normal (ULN) (except patients with Gilbert syndrome, who can have total ... Sjögren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear ... Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective ...

*  Awareness Ribbon Color Meanings

Short Bowel Syndrome Awareness Ribbons - MARCH. Steven Johnson Syndrome Awareness Ribbons - AUGUST ...

*  How U.S. Supreme Court Just Made It Tougher to Challenge California Vaccine Law | State of Health | KQED News

Stevens-Johnson syndrome; erythema multiforme; urticaria; rash; measles-like rash; pruritis.. Local reactions including burning ... Mike Stevens "Even your own vacc supporting peeps are like "dude, just shut up, you make us look worse".". Well I'm saying " ... Mike Stevens "However, the data suggest the possibility that some of these cases. may have been caused by measles vaccines. The ... Mike Stevens I think you'll find none of "us" have ever said vaccines have no side effects.. It all boils down to a question of ...

*  Phenytoin Capsules - FDA prescribing information, side effects and uses

Other more serious forms which may be fatal have included bullous, exfoliative or purpuric dermatitis, Stevens-Johnson syndrome ... Serious and sometimes fatal dermatologic reactions, including toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome ( ...

*  Gammagard (Immune Globulin): Side Effects, Interactions, Warning, Dosage & Uses

Integumentary: bullous dermatitis, epidermolysis, erythema multiforme, Stevens- Johnson syndrome. Cardiovascular: cardiac ... Kawasaki Syndrome. For patients with Kawasaki syndrome, either a single 1 g/kg dose or a dose of 400 mg/kg for four consecutive ... Kawasaki Syndrome. In a study of patients (n=51) with Kawasaki syndrome, no hypersensitivity-type reactions (urticaria, ... associated with Kawasaki syndrome. The percentage incidence of coronary artery aneurysm in patients with Kawasaki syndrome ...

*  CMSC INforMS: New Analysis Suggests Aubagio Slows Brain Atrophy in People with Relapsing MS - Consortium of Multiple Sclerosis...

Interstitial lung disease and rare cases of Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported with ...

*  Zosyn Side Effects in Detail - Drugs.com

Postmarketing reports: Erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with ... Stevens-Johnson syndrome, purpura, vasculitis[Ref]. Other. Piperacillin therapy has been associated with an increased incidence ... Stevens-Johnson syndrome, dyspnea, hypotension, and edema) have been reported. Hypersensitivity reactions (including fever, ... Moore M, McNamara TR, Johnson J "Elevated bleeding time and epistaxis associated with piperacillin therapy." South Med J 78 ( ...

Stevens–Johnson syndromeConjunctivochalasisCarbamazepineErythema multiforme majorDrug eruptionLigneous conjunctivitis: Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva). It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia.AllopurinolNeuro-ophthalmology: Neuro-ophthalmology is an academically-oriented subspecialty that merges the fields of neurology and ophthalmology, often dealing with complex systemic diseases that have manifestations in the visual system. Neuro-ophthalmologists initially complete a residency in either neurology or ophthalmology, then do a fellowship in the complementary field.Protective index: The protective index is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity. Quantitatively, it is the ratio given by the toxic dose divided by the therapeutic dose.DysuriaBullous keratopathyMycoplasma pneumoniaSurface reconstruction: Surface reconstruction refers to the process by which atoms at the surface of a crystal assume a different structure than that of the bulk. Surface reconstructions are important in that they help in the understanding of surface chemistry for various materials, especially in the case where another material is adsorbed onto the surface.Malformative syndrome: A malformative syndrome (or malformation syndrome) is a recognizable pattern of congenital anomalies that are known or thought to be causally related (VIIth International Congress on Human Genetics).Drug allergyIdiosyncratic drug reactionChemical eye injury: Chemical eye injury or chemical burns to the eye are due to either an acidic or alkali substance getting in the eye. Alkalis are typically worse than acidic burns.Conjunctiva: The conjunctiva lines the inside of the eyelids and covers the sclera (white part of the eye). It is composed of non-keratinized, stratified columnar epithelium with goblet cells, and also stratified columnar epithelium.PhenytoinLennox–Gastaut syndrome

(1/219) Epithelial hyperproliferation and transglutaminase 1 gene expression in Stevens-Johnson syndrome conjunctiva.

In Stevens-Johnson syndrome, pathological keratinization of the ordinarily nonkeratinized corneal and conjunctival mucosal epithelia results in severe visual loss. We examined conjunctiva covering cornea in five eyes in the chronic cicatricial phase of Stevens-Johnson syndrome. Normal conjunctiva from five age-matched individuals was studied also. The number of epithelial cells in Stevens-Johnson syndrome conjunctiva that were immunoreactive with a monoclonal antibody, Ki-67, to a nuclear antigen found only in proliferating cells was greater than normal (93.8+/-19.8 cells above 100 basal cells versus 12.8+/-0.5 cells above 100 basal cells; P = 0.009). In addition, although clinical inflammation was mild, massive lymphocytic infiltration was seen in the substantia propria of conjunctiva covering cornea. In situ hybridization documented transglutaminase 1 (keratinocyte transglutaminase) mRNA in suprabasal cells of the abnormally thickened conjunctival epithelium in all Stevens-Johnson syndrome patients. In contrast, no message was detected in normal conjunctival or corneal epithelia. Transglutaminase 1 is expressed during the terminal differentiation of keratinocytes where it helps synthesize cornified cell envelopes. We speculate that in Stevens-Johnson syndrome, epithelial hyperproliferation, and transglutaminase 1 gene expression lead to the pathological keratinization of ocular surface mucosal epithelia.  (+info)

(2/219) Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors.

Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse drug reaction characterized by a massive destruction of the epidermis. Immunohistological studies of skin biopsies of TEN showed infiltrates of predominantly CD8+ T lymphocytes even though other authors reported a prominent involvement of cells of the monocyte-macrophage lineage. The aim of this study was to characterize phenotypically and functionally the cells present in the cutaneous blister fluid of four patients with TEN. We first determined that lymphocytes were predominant in blister fluid obtained early, while monocytes/macrophages later became the most important population. We then showed that this lymphocyte population, mainly CD3+CD8+, corresponded to a peculiar cell subset as they expressed cutaneous leucocyte antigen, killer inhibitory receptors KIR/KAR and failed to express CD28 molecule. Functionally, we determined that blister T lymphocytes had a cytotoxic T lymphocyte (CTL)- and NK-like cytotoxicity. The role of this cytotoxic lymphocyte population present at the site of lesions during TEN remains to be understood.  (+info)

(3/219) Nitric oxide synthase in toxic epidermal necrolysis and Stevens-Johnson syndrome.

Toxic epidermal necrolysis and Stevens-Johnson syndrome are severe cutaneous drug reactions of unknown mechanism. Nitric oxide can cause apoptosis and necrosis. The inducible form of nitric oxide synthase generates large amounts of nitric oxide and has been described in human skin. We propose that a large burst of nitric oxide in toxic epidermal necrolysis and Stevens-Johnson syndrome may cause the epidermal apoptosis and necrosis. Skin biopsies were taken from seven patients with actively progressing Stevens-Johnson syndrome or toxic epidermal necrolysis. Expression of inducible nitric oxide synthase was examined by reverse transcription-polymerase chain reaction and by immunoperoxidase staining for inducible nitric oxide synthase protein. Messenger RNA for inducible nitric oxide synthase was detected by reverse transcription-polymerase chain reaction and confirmed by the sequencing of polymerase chain reaction products. Strong staining for inducible nitric oxide synthase was observed in inflammatory cells in the lower epidermis and upper dermis. Diffuse, weaker staining was observed in keratinocytes. Expression of inducible nitric oxide synthase is consistent with the hypothesis that nitric oxide mediates the epidermal necrosis in toxic epidermal necrolysis and provides a potential target for therapeutic intervention.  (+info)

(4/219) SCORTEN: a severity-of-illness score for toxic epidermal necrolysis.

The mortality of toxic epidermal necrolysis is about 30%. Our purpose was to develop and validate a specific severity-of-illness score for cases of toxic epidermal necrolysis admitted to a specialized unit and to compare it with the Simplified Acute Physiology Score and a burn scoring system. A sample of 165 patients was used to develop the toxic epidermal necrolysis-specific severity-of-illness score and evaluate the other scores, a sample of 75 for validation. Model development used logistic regression equations that were translated into probability of hospital mortality; validation used measures of calibration and discrimination. We identified seven independent risk factors for death and constituted the toxic epidermal necrolysis-specific severity-of-illness score: age above 40 y, malignancy, tachycardia above 120 per min, initial percentage of epidermal detachment above 10%, serum urea above 10 mmol per liter, serum glucose above 14 mmol per liter, and bicarbonate below 20 mmol per liter. For each toxic epidermal necrolysis-specific severity-of-illness score point the odds ratio was 3.45 (confidence interval 2.26-5.25). Probability of death was: P(death) = elogit/1 + elogit with logit = -4.448 + 1.237 (toxic epidermal nec-rolysis-specific severity-of-illness score). Calibration demonstrated excellent agreement between expected (19. 6%) and actual (20%) mortality; discrimination was also excellent with a receiver operating characteristic area of 82%. The Simplified Acute Physiology Score and the burn score were also associated with mortality. The discriminatory powers were poorer (receiver operating characteristic area: 72 and 75%) and calibration of the Simplified Acute Physiology Score indicated a poor agreement between expected (9.1%) and actual (26.7%) mortality. This study demonstrates that the risk of death of toxic epidermal necrolysis patients can be accurately predicted by the toxic epidermal necrolysis-specific severity-of-illness score. The Simplified Acute Physiology Score and burn score appear to be less adequate.  (+info)

(5/219) Diagnosis, classification, and management of erythema multiforme and Stevens-Johnson syndrome.

BACKGROUND: In adults, erythema multiforme (EM) is thought to be mainly related to herpes infection and Stevens-Johnson syndrome (SJS) to drug reactions. AIMS: To investigate this hypothesis in children, and to review our experience in the management of these patients. METHODS: A retrospective analysis of 77 paediatric cases of EM or SJS admitted to the Children's Hospital in Bordeaux between 1974 and 1998. RESULTS: Thirty five cases, inadequately documented or misdiagnosed mostly as urticarias or non-EM drug reactions were excluded. Among the remaining 42 patients (14 girls and 28 boys), 22 had EM (11 EM minor and 11 EM major), 17 had SJS, and three had isolated mucous membrane involvement and were classified separately. Childhood EM was mostly related to herpes infection and SJS to infectious agents, especially Mycoplasma pneumoniae. Only two cases were firmly attributed to drugs (antibiotics). No patient died. EM and SJS sequelae were minor and steroids were of no overall benefit. CONCLUSION: In paediatric practice EM is frequently misdiagnosed. The proposal that SJS is drug related in adults does not apply to children, and in our recruitment EM and SJS are mostly triggered by infectious agents. The course of both diseases, even though dramatic at onset, leads to low morbidity and mortality when appropriate symptomatic treatment is given.  (+info)

(6/219) Conjunctival inflammation in the chronic phase of Stevens-Johnson syndrome.

AIMS: To understand the immunopathogenesis of the corneal conjunctivalisation in Stevens-Johnson syndrome. METHODS: Conjunctivalised corneas from five patients with Stevens-Johnson syndrome were studied immunohistochemically for several cell surface antigens and two cytokines. Chemical injury specimens were also studied. RESULTS: In all cases, immunohistochemistry revealed LFA-1, CD4, CD8, and CD68 on subepithelial infiltrating cells. Also, HLA-DR and ICAM-1 were found on the surfaces of epithelial cells, subepithelial infiltrating cells, subepithelial fibroblasts, and endothelial cells in blood vessels. IFN-gamma was found in basal epithelial cells; subepithelial cells and subepithelial extracellular matrix CD19 and IL4 were not detected. CONCLUSIONS: The infiltrating cell population in the Stevens-Johnson syndrome samples includes macrophages, CD4 positive T cells, and CD8 positive T cells. The cytokine expression pattern suggests CD4 positive T cells are Th1 cells. The infiltrating cell population is similar in Stevens-Johnson syndrome and chemical injury conjunctivalised corneas.  (+info)

(7/219) Toxic epidermal necrolysis in a monkey (Macaca fascicularis).

An adult male Macaca fascicularis monkey developed toxic epidermal necrolysis after ingestion of methylmercury. The clinical picture was characterized by the development of large cutaneous bullae with subsequent full-thickness epidermal exfoliation. Areas of sparse pelage were most affected, with the most severe exfoliation occurring on the palms, soles, face and ears. Erosions also developed within the oral mucosa and conjunctivae.  (+info)

(8/219) Patients with acute skin loss: are they best managed on a burns unit?

Patients who are critically ill and have large areas of skin loss or breakdown present a difficult management problem. They require the combination of intensive therapy facilities to support failing organs and specialized skin care, sometimes including extensive debridement and reconstruction. The expertise required for both aspects of treatment are found uniquely on a burns unit. We present five patients with large areas of cutaneous loss or damage secondary to a variety of non-burn aetiologies who were managed on a burns unit. We suggest that a burns unit may be the most appropriate place for such patients to be treated during both the acute phase of their illness and the later stages of surgical reconstruction and physical rehabilitation.  (+info)



erythema multiforme

  • Stevens-Johnson syndrome (erythema multiforme major) is a serious disorder affecting the skin and mucous membranes related to a hypersensitivity reaction that usually occurs in response to medications and sometimes infection. (shrinershospitalsforchildren.org)
  • erythema multiforme, including Stevens-Johnson syndrome. (drugs.com)

stomach

  • It is used to treat syndromes caused by lots of stomach acid. (drugs.com)

infection

  • suffer from a severe infection, such as tuberculosis, HIV or other immunodeficiency syndromes. (drugs.com)

diagnosis

  • Overall Bottom Line: A diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS) should be considered for any complaint of excessive daytime sleepiness. (essentialevidenceplus.com)

treat

  • It is used to treat irritable bowel syndrome. (drugs.com)

skin

  • This syndrome usually begins with flu-like symptoms, followed by a painful red or purplish rash that spreads and blisters, eventually causing the top layer of skin to die and shed (slough). (shrinershospitalsforchildren.org)