*  Stephania tetrandra - Wikipedia

Stephania tetrandra is a herbaceous perennial vine of the Menispermaceae family native to China and Taiwan. It grows from a ... Stephania tetrandra is among the 50 fundamental herbs used in TCM. The standard pinyin according to the Chinese [Herbal] ... "Stephania tetrandra". Flora of China. Missouri Botanical Garden, St. Louis, MO & Harvard University Herbaria, Cambridge, MA. ... Its root is used in traditional Chinese medicine (TCM). Stephania tetrandra occurs in shrublands at village margins, open ...

*  Chinese herbology - Wikipedia

Stephania tetrandra. fáng jǐ (防己). Stephania Root. Styphnolobium japonicum (formerly Sophora japonica). huái (槐), huái shù (槐树 ...

*  HeteroCycles

New Alkaloids from the Root of Stephania tetrandra (Fen-Fang-Ji). Tatsunori Ogino,* Takao Katsuhara, Toshitsugu Sato, Hiroshi ... Four new alkaloids named fenfangjines F, G, H, and I were isolated from the root of Stephania tetrandra S. Moore, the Chinise ...

*  Preparation and characterization of tetrandrine-phospholipid complex l | IJN

Tetrandrine is an active constituent that is extracted from the root tuber of the Chinese herb Stephania tetrandra S. Moore. It ... Background: Tetrandrine is an active constituent that is extracted from the root tuber of the Chinese herb Stephania tetrandra ...

*  List of MeSH codes (B06) - Wikipedia

... stephania (wd , gwp gwe g , in it p) MeSH B06.388.100.725.750.500 --- stephania tetrandra (wd , gwp gwe g , in it p) MeSH ...

*  Fangchinoline - Wikipedia

Fangchinoline is an isolate of Stephania tetrandra that has anticancer activity. Fangchinoline Induces G1 Arrest in Breast ...

*  Aristolochic acid - Wikipedia

List of herbs with known adverse effects Stephania tetrandra Wu, Tian-Shung; et al. (2005). "Chemical constituents and ...

*  Tetrandrine - Wikipedia

It has been isolated from Stephania tetrandra S Moore, and other Chinese and Japanese herbs. It has vasodilatory properties and ...

*  Seek Natural Health Products Shop & Herbal Remedies UK

Stephania tetrandra root extract, long used in China and Korea, suppresses multiple inflammatory cytokines, especially ...

*  Stephania - Wikipedia

Stephania tetrandra, has not been shown to be toxic. Any confusion regarding the possible toxicity of Stephania tetrandra was ... Flora of China: Stephania species list Flora of Nepal: Stephania species list. ... The name Stephania comes from the Greek, "a crown". This refers to the anthers being arranged in a crown like manner. One ... "Isoquinolone and protoberberine alkaloids from Stephania rotunda". Die Pharmazie. 60 (9): 701-704. PMID 16222872. "Stephania ...

*  Menispermaceae | Article about Menispermaceae by The Free Dictionary

Root Menispermaceae (Fangji Ke [TEXT NOT REPRODUCIBLE IN ASCII]) Stephania tetrandra S.. Complexities of the herbal ... Stephania Menispermaceae Doi pata, Flower japonica Aknadi (Thunb.. A Randomized survey of medicinal plants used by folk ... The roots, bark, and fruits of many species (of the genera Tinospora, Conculus, and Stephania) contain bitter substances and ... Labiatae Stephania Menispermaceae Techamoti japonica (Thunb.. An ethnoveterinary survey of medicinal plants used to treat ...

*  Most recent papers with the keyword GRP | Read by QxMD

Tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the roots of Stephania tetrandra is a traditional Chinese medicine ...

*  Aristolochia - Wikipedia

... where Stephania tetrandra in a herbal preparation was suspected of being substituted with Aristolochia fangchi. More than 105 ... 1994) The names han fang ji (漢防己, Chinese fang ji - S. tetrandra) and guan fang ji (廣防己, Broad fang ji - A. fanchi) had ...

*  UNTHSC Scholarly Repository - Research Appreciation Day: TETRANDRINE INDUCED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF...

Tetrandrine, a bis-benzylisoquinoline alkaloid isolated from the root of Stephania tetrandra, is a calcium channel blocker used ...

*  Leukemia: A New Prevention and Treatment Paradigm | Acupuncture Integrated

These herbs studied were Dan shen (Salvia miltiorrhiza), Han fang ji (Stephania tetrandra:), Hou pou (Magnolia officianalis), E ...

*  Herbalism - Akashic Hall of Records

Stephania tetrandra) was swapped for another (Aristolochia fangchi) whose name in Chinese was extremely similar but which ...

*  Nutrient

Stephania tetrandra. Stevia Stinging nettle i. e. Bichu ghas Straw Mushroom. Strawberry ...

(1/6) Anti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra Radix in streptozotocin-diabetic mice.

Kampo medicine, Stephania tetrandra Radix (Stephania) in Boi-ogi-to increases the blood insulin level and falls the blood glucose level in streptozotocin (STZ)-diabetic ddY mice. These actions of Stephania are potentiated by Astragalus membranaceus Bunge Radix (Astragali) in Boi-ogi-to (Liu et al., J. Traditional Med., 17, 253-260, 2000). In the present study, actions of bis-benzylisoquinoline alkaloids isolated from Stephania were investigated in the hyperglycemia of STZ-diabetic mice. A main bis-benzylisoquinoline alkaloid, fangchinoline (0.3-3 mg/kg) significantly fell the blood glucose level of the diabetic mice in a dose-dependent manner. The effect of fangchinoline was 3.9-fold greater than that of water extract of Stephania. However, another main compound, tetrandrine (1-100 mg/kg) did not have any effect. The water extract of Astragali did not affect singly but potentiated the anti-hyperglycemic action of fangchinoline (0.3 mg/kg). Out of used compounds (1 mg/kg) isolated from Stephania, fangchinoline, fangchinoline 2'-N-alpha-oxide and 2'-N-norfangchinoline, which are substituted with 7-hydroxy side chain for 7-O-methyl side chain, decreased to near 50% of high blood glucose level. In addition, tetrandrine 2'-N-beta-oxide, tetrandrine 2'-N-alpha-oxide, tetrandrine 2-N-beta-oxide, fangchinoline 2'-N-alpha-oxide, which are added to 2- or 2'-N-oxide side chain, also decreased to near 50% of the high blood glucose level. In conclusion, fangchinoline but not tetrandrine from Stephania shows the anti-hyperglycemic action in the STZ-diabetic mice. The demethylation of 7-O-position and/or addition of 2- or 2'-N-oxide side chain in bis-benzylisoquinoline compounds in Stephania have a role for the induction of the anti-hyperglycemic actions.  (+info)

(2/6) Inhibitory effects of Stephania tetrandra S. Moore on free radical-induced lysis of rat red blood cells.

Crude preparations of Stephania tetrandra S. MOORE (ST), a traditional herbal medicine, have been used safely for arthritis and silicosis in China. In this study, we demonstrated that ST in vitro protects red blood cells from 2,2-azo-bis (2-amidinopropane) dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 10 to 1000 microg/ml. Moreover, tests were carried out to identify the main ingredient of ST that exerts a scavenging effect on free-radicals. Three representative alkaloids, tetrandrine, fangchinoline, and cyclanoline, isolated from ST, were found to have inhibitory activities against AAPH-induced lysis of red blood cells (RBC). Furthermore, the ingestion of 200 mg of ST extract was associated with a significant increase in free-radical scavenging effect of plasma in rats. These results suggest that ST as antioxidant inhibits AAPH-induced hemolysis of RBC both in vitro and in vivo.  (+info)

(3/6) Combined effects of fangchinoline from Stephania tetrandra Radix and formononetin and calycosin from Astragalus membranaceus Radix on hyperglycemia and hypoinsulinemia in streptozotocin-diabetic mice.

The anti-hyperglycemic action of Stephania tetrandra Radix (Stephania) is potentiated by Astragalus membranaceus BUNGE Radix (Astragali) in streptozotocin (STZ)-diabetic ddY mice (Tsutsumi et al., Biol. Pharm. Bull., 26, 313 (2003)). Fangchinoline (0.3-3 mg/kg), a main constituent of Stephania, decreased the high level of blood glucose and increased the low level of blood insulin in STZ-diabetic mice. Here, we investigated the combined effects of fangchinoline with isoflavone or isoflavonoid components (formononetin, calycosin and ononin) of Astragali on the hyperglycemia and hypoinsulinemia of STZ-diabetic mice. Formononetin, calycosin and ononin (0.03-0.1 mg/kg) alone did not affect the blood glucose or blood insulin level of the diabetic mice. Formononetin and calycosin (0.03-0.1 mg/kg) potentiated the anti-hyperglycemic action of fangchinoline (0.3 mg/kg), but ononin did not. Formononetin (0.1 mg/kg) facilitated the fangchinoline-induced insulin release, and calycosin (0.1 mg/kg) also facilitated it, though without statistical significance. In conclusion, the combined effect of fangchinoline with formononetin and calycosin on hyperglycemia in the diabetic mice accounted well for the therapeutic effect of the combination of Stephania with Astragali in Boi-ogi-to. The anti-hyperglycemic action of formononetin appeared to be due to its potentiating action on insulin release. Our strategy for studying combinations of crude drugs and their components in Kampo medicine has uncovered new potentiating effects of formononetin and calycosin on the anti-hyperglycemic action of fangchinoline in STZ-diabetic mice.  (+info)

(4/6) Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis.

Radix Stephaniae tetrandrae, which contains tetrandrine (Tet) and fangchinoline, is traditionally used as an analgesic, antirheumatic, and antihypertensive drug in China. In this study, we investigated its effect on breast cancer cell proliferation and its potential mechanism of action in vitro. Treatment of cells with fangchinoline significantly inhibited MDA-MB-231 cell proliferation in a concentration- and time-dependent manner. To define the mechanism underlying the antiproliferative effects of fangchinoline, we studied its effects on critical molecular events known to regulate the apoptotic machinery. Specifically, we addressed the potential of fangchinoline to induce apoptosis of breast cancer cells. Fangchinoline induced internucleosomal DNA fragmentation, chromatin condensation, activation of caspases-3, -8, and -9, and cleavage of poly(ADP ribose) polymerase, as well as enhanced mitochondrial cytochrome c release. Furthermore, fangchinoline increased the expression of the proapoptotic protein B cell lymphoma-2 associated X (Bax) and decreased the expression of the antiapoptotic protein B cell lymphoma-2 (Bcl-2). In addition, the proliferation-inhibitory effect of fangchinoline was associated with decreased levels of phosphorylated Akt. Our results indicate that fangchinoline can inhibit breast cancer cell proliferation by inducing apoptosis via the mitochondrial apoptotic pathway and decreasing phosphorylated Akt. Thus fangchinoline may be a novel agent that can potentially be developed clinically to target human malignancies.  (+info)

(5/6) Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.

 (+info)

(6/6) Simultaneous determination of structurally diverse compounds in different Fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MS.

 (+info)



Alkaloids

  • Stephania alkaloids have curare-like action, and can selectively inhibit T-cell-dependent immune reactions. (wikipedia.org)
  • The roots, bark, and fruits of many species (of the genera Tinospora, Conculus , and Stephania ) contain bitter substances and poisonous alkaloids, such as iatrorhyze, and are used medicinally, particularly in tropical countries. (thefreedictionary.com)

fangchinoline

  • Fangchinoline is an isolate of Stephania tetrandra that has anticancer activity. (wikipedia.org)

Root

  • Tetrandrine is an active constituent that is extracted from the root tuber of the Chinese herb Stephania tetrandra S. Moore. (dovepress.com)
  • Stephania tetrandra root extract, long used in China and Korea, suppresses multiple inflammatory cytokines, especially interleukin-6, associated with elevated C-reactive protein. (seeknatural.co.uk)
  • Root Menispermaceae (Fangji Ke [TEXT NOT REPRODUCIBLE IN ASCII]) Stephania tetrandra S. (thefreedictionary.com)
  • Tetrandrine, a bis-benzylisoquinoline alkaloid isolated from the root of Stephania tetrandra , is a calcium channel blocker used in Chinese medicine for the treatment of silicosis and arthritis. (unt.edu)

Aristolochia

  • Any confusion regarding the possible toxicity of Stephania tetrandra was entirely due to an inadvertent shipment of Aristolochia fangchi sent in its stead to a Belgian clinic in 1993. (wikipedia.org)
  • citation needed] In 1993, a series of end-stage renal disease cases was reported from Belgium associated with a weight loss treatment, where Stephania tetrandra in a herbal preparation was suspected of being substituted with Aristolochia fangchi. (wikipedia.org)

Moore

  • It has been isolated from Stephania tetrandra S Moore, and other Chinese and Japanese herbs. (wikipedia.org)

Menispermaceae

  • Stephania tetrandra is a herbaceous perennial vine of the Menispermaceae family native to China and Taiwan. (wikipedia.org)
  • Stephania is a genus of flowering plants in the family Menispermaceae, native to eastern and southern Asia and Australasia. (wikipedia.org)
  • Three acetylcholinesterase inhibitors (which have recently gained importance as potential drugs in the treatment of Alzheimer's disease) have been isolated from tubers of a Thai medicinal plant belonging to the Menispermaceae family, namely Stephania venosa. (thefreedictionary.com)
  • Labiatae Stephania Menispermaceae Techamoti japonica (Thunb. (thefreedictionary.com)
  • Stephania Menispermaceae Doi pata, Flower japonica Aknadi (Thunb. (thefreedictionary.com)

species

  • There are about 45 species in the genus Stephania, native to the Far East and Australasia. (wikipedia.org)
  • Species include: There is evidence that a few species of Stephania are toxic. (wikipedia.org)
  • However, the most commonly available species in the United States, Stephania tetrandra, has not been shown to be toxic. (wikipedia.org)

herbs

  • Stephania tetrandra is among the 50 fundamental herbs used in TCM. (wikipedia.org)