**Statistics as Topic**: The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.

**Vital Statistics**: Used for general articles concerning statistics of births, deaths, marriages, etc.

**National Center for Health Statistics (U.S.)**: A center in the PUBLIC HEALTH SERVICE which is primarily concerned with the collection, analysis, and dissemination of health statistics on vital events and health activities to reflect the health status of people, health needs, and health resources.

**Models, Statistical**: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

**Data Interpretation, Statistical**: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.

**Reproducibility of Results**: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

**Algorithms**: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

**Computer Simulation**: Computer-based representation of physical systems and phenomena such as chemical processes.

**Statistics, Nonparametric**: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

**Models, Genetic**: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

**United States**

**Death Certificates**: Official records of individual deaths including the cause of death certified by a physician, and any other required identifying information.

**Space-Time Clustering**: A statistically significant excess of cases of a disease, occurring within a limited space-time continuum.

**Observer Variation**: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).

**Software**: Sequential operating programs and data which instruct the functioning of a digital computer.

**Statistical Distributions**: The complete summaries of the frequencies of the values or categories of a measurement made on a group of items, a population, or other collection of data. The distribution tells either how many or what proportion of the group was found to have each value (or each range of values) out of all the possible values that the quantitative measure can have.

**Mortality**: All deaths reported in a given population.

**Likelihood Functions**: Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.

**Cause of Death**: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.

**Biometry**: The use of statistical and mathematical methods to analyze biological observations and phenomena.

**Statistics**

**Monte Carlo Method**: In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)

**Infant, Newborn**: An infant during the first month after birth.

**Biostatistics**: The application of STATISTICS to biological systems and organisms involving the retrieval or collection, analysis, reduction, and interpretation of qualitative and quantitative data.

**Data Collection**: Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.

**Probability**: The study of chance processes or the relative frequency characterizing a chance process.

**Sensitivity and Specificity**: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

**Questionnaires**: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.

**Age Distribution**: The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.

**Bayes Theorem**: A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.

**Sample Size**: The number of units (persons, animals, patients, specified circumstances, etc.) in a population to be studied. The sample size should be big enough to have a high likelihood of detecting a true difference between two groups. (From Wassertheil-Smoller, Biostatistics and Epidemiology, 1990, p95)

**Poisson Distribution**: A distribution function used to describe the occurrence of rare events or to describe the sampling distribution of isolated counts in a continuum of time or space.

**Cluster Analysis**: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.

**Risk Factors**: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

**Cross-Sectional Studies**: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.

**England**

**Age Factors**: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

**Time Factors**: Elements of limited time intervals, contributing to particular results or situations.

**Databases, Factual**: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.

**Incidence**: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

**Registries**: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.

**Population Surveillance**: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.

**Sex Distribution**: The number of males and females in a given population. The distribution may refer to how many men or women or what proportion of either in the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.

**Retrospective Studies**: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

**Canada**: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.

**Research Design**: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.

**Regression Analysis**: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.

**Demography**: Statistical interpretation and description of a population with reference to distribution, composition, or structure.

**Genetics, Population**: The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.

**Sex Factors**: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.

**Socioeconomic Factors**: Social and economic factors that characterize the individual or group within the social structure.

**Computational Biology**: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.

**Wounds and Injuries**: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.

**Health Surveys**: A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.

**Geographic Information Systems**: Computer systems capable of assembling, storing, manipulating, and displaying geographically referenced information, i.e. data identified according to their locations.

**Poisoning**: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.

**Birth Certificates**: Official certifications by a physician recording the individual's birth date, place of birth, parentage and other required identifying data which are filed with the local registrar of vital statistics.

**Birth Rate**: The number of births in a given population per year or other unit of time.

**Genetic Linkage**: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.

**Life Expectancy**: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.

**Nuclear Family**: A family composed of spouses and their children.

**Infant Mortality**: Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.

**Prevalence**: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

**Linkage Disequilibrium**: Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.

**International Classification of Diseases**: A system of categories to which morbid entries are assigned according to established criteria. Included is the entire range of conditions in a manageable number of categories, grouped to facilitate mortality reporting. It is produced by the World Health Organization (From ICD-10, p1). The Clinical Modifications, produced by the UNITED STATES DEPT. OF HEALTH AND HUMAN SERVICES, are larger extensions used for morbidity and general epidemiological purposes, primarily in the U.S.

**ROC Curve**: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.

**Bias (Epidemiology)**: Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.

**Nature**: The system of all phenomena in space and time; the totality of physical reality. It is both a scientific and philosophic concept appearing in all historic eras. (Webster 2d; Dr. James H. Cassedy, NLM History of Medicine Division)

**Models, Theoretical**: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

**Normal Distribution**: Continuous frequency distribution of infinite range. Its properties are as follows: 1, continuous, symmetrical distribution with both tails extending to infinity; 2, arithmetic mean, mode, and median identical; and 3, shape completely determined by the mean and standard deviation.

**Geography**: The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)

**Logistic Models**: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.

**Cohort Studies**: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

**Diffusion Tensor Imaging**: The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.

**Anisotropy**: A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.

**Wales**

**Risk Assessment**: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)

**Genome-Wide Association Study**: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.

**Predictive Value of Tests**: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

**Genetic Variation**: Genotypic differences observed among individuals in a population.

**Ethnic Groups**: A group of people with a common cultural heritage that sets them apart from others in a variety of social relationships.

**Confidence Intervals**: A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.

**Chromosome Mapping**: Any method used for determining the location of and relative distances between genes on a chromosome.

**Genetic Markers**: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.

**Models, Neurological**: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

**Epidemiologic Methods**: Research techniques that focus on study designs and data gathering methods in human and animal populations.

**Pregnancy**: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

**Internet**: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

**Stochastic Processes**: Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.

**Neoplasms**: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

**Great Britain**

**Linear Models**: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.

**Health Status Indicators**: The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.

**Small-Area Analysis**: A method of analyzing the variation in utilization of health care in small geographic or demographic areas. It often studies, for example, the usage rates for a given service or procedure in several small areas, documenting the variation among the areas. By comparing high- and low-use areas, the analysis attempts to determine whether there is a pattern to such use and to identify variables that are associated with and contribute to the variation.

**Prospective Studies**: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

**Image Processing, Computer-Assisted**: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.

**Models, Biological**: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

**Censuses**: Enumerations of populations usually recording identities of all persons in every place of residence with age or date of birth, sex, occupation, national origin, language, marital status, income, relation to head of household, information on the dwelling place, education, literacy, health-related data (e.g., permanent disability), etc. The census or "numbering of the people" is mentioned several times in the Old Testament. Among the Romans, censuses were intimately connected with the enumeration of troops before and after battle and probably a military necessity. (From Last, A Dictionary of Epidemiology, 3d ed; Garrison, An Introduction to the History of Medicine, 4th ed, p66, p119)

**Spatial Analysis**: Techniques which study entities using their topological, geometric, or geographic properties.

**Chi-Square Distribution**: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.

**Public Health Informatics**: The systematic application of information and computer sciences to public health practice, research, and learning.

**Homicide**: The killing of one person by another.

**Analysis of Variance**: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.

**Forms and Records Control**: A management function in which standards and guidelines are developed for the development, maintenance, and handling of forms and records.

**Health Status**: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.

**Mathematical Computing**: Computer-assisted interpretation and analysis of various mathematical functions related to a particular problem.

**Suicide**: The act of killing oneself.

**Genotype**: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

**Haplotypes**: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.

**Quality Control**: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)

**Pattern Recognition, Automated**: In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)

**Hospitalization**: The confinement of a patient in a hospital.

**Continental Population Groups**: Groups of individuals whose putative ancestry is from native continental populations based on similarities in physical appearance.

**Case-Control Studies**: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

**Alleles**: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.

**Image Interpretation, Computer-Assisted**: Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.

**Markov Chains**: A stochastic process such that the conditional probability distribution for a state at any future instant, given the present state, is unaffected by any additional knowledge of the past history of the system.

**Residence Characteristics**: Elements of residence that characterize a population. They are applicable in determining need for and utilization of health services.

**Gene Expression Profiling**: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

**European Continental Ancestry Group**: Individuals whose ancestral origins are in the continent of Europe.

**Genetic Diseases, Inborn**: Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.

**Brazil**

**Matched-Pair Analysis**: A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).

**Multivariate Analysis**: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.

**Severity of Illness Index**: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

**Numerical Analysis, Computer-Assisted**: Computer-assisted study of methods for obtaining useful quantitative solutions to problems that have been expressed mathematically.

**Oligonucleotide Array Sequence Analysis**: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

**Genome, Human**: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.

**Gene Frequency**: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.

**Meta-Analysis as Topic**: A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.

**Topography, Medical**: The systematic surveying, mapping, charting, and description of specific geographical sites, with reference to the physical features that were presumed to influence health and disease. Medical topography should be differentiated from EPIDEMIOLOGY in that the former emphasizes geography whereas the latter emphasizes disease outbreaks.

**Psychometrics**: Assessment of psychological variables by the application of mathematical procedures.

**Databases, Genetic**: Databases devoted to knowledge about specific genes and gene products.

**False Positive Reactions**: Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)

**Accidents**

**Nerve Fibers, Myelinated**: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.

**Spatio-Temporal Analysis**: Techniques which study entities using their topological, geometric, or geographic properties and include the dimension of time in the analysis.

**Treatment Outcome**: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

**Clinical Coding**: Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)

**Accidents, Occupational**: Unforeseen occurrences, especially injuries in the course of work-related activities.

**Health Services Accessibility**: The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.

**Health Care Surveys**: Statistical measures of utilization and other aspects of the provision of health care services including hospitalization and ambulatory care.

**Longitudinal Studies**: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.

**User-Computer Interface**: The portion of an interactive computer program that issues messages to and receives commands from a user.

**History, 20th Century**: Time period from 1901 through 2000 of the common era.

**Morbidity**: The proportion of patients with a particular disease during a given year per given unit of population.

**Sequence Analysis, DNA**: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

**Health Services**: Services for the diagnosis and treatment of disease and the maintenance of health.

**Prognosis**: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

**Medical Record Linkage**: The creation and maintenance of medical and vital records in multiple institutions in a manner that will facilitate the combined use of the records of identified individuals.

**Medical Records**: Recording of pertinent information concerning patient's illness or illnesses.

**Educational Status**: Educational attainment or level of education of individuals.

**Hospital Records**: Compilations of data on hospital activities and programs; excludes patient medical records.

**Photic Stimulation**: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.

**Periodicals as Topic**: A publication issued at stated, more or less regular, intervals.

**Quantitative Trait Loci**: Genetic loci associated with a QUANTITATIVE TRAIT.

**Interviews as Topic**: Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.

**Follow-Up Studies**: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

**Visual Perception**: The selecting and organizing of visual stimuli based on the individual's past experience.

**Risk**: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.

**Norway**

**Epidemiologic Measurements**: Statistical calculations on the occurrence of disease or other health-related conditions in defined populations.

**Coroners and Medical Examiners**: Physicians appointed to investigate all cases of sudden or violent death.

**China**: A country spanning from central Asia to the Pacific Ocean.

**Forecasting**: The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.

**Quantitative Trait, Heritable**: A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)

**Episode of Care**: An interval of care by a health care facility or provider for a specific medical problem or condition. It may be continuous or it may consist of a series of intervals marked by one or more brief separations from care, and can also identify the sequence of care (e.g., emergency, inpatient, outpatient), thus serving as one measure of health care provided.

**Software Validation**: The act of testing the software for compliance with a standard.

**Least-Squares Analysis**: A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.

**Genetic Predisposition to Disease**: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

**Accidents, Traffic**: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.

**Annual Reports as Topic**: Annual statements reviewing the status of the administrative and operational functions and accomplishments of an institution or organization.

**Government Agencies**: Administrative units of government responsible for policy making and management of governmental activities.

**Patient Discharge**: The administrative process of discharging the patient, alive or dead, from hospitals or other health facilities.

**Japan**

**Brain**: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

**Psychophysics**: The science dealing with the correlation of the physical characteristics of a stimulus, e.g., frequency or intensity, with the response to the stimulus, in order to assess the psychologic factors involved in the relationship.

**Magnetic Resonance Imaging**: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

**Population**: The total number of individuals inhabiting a particular region or area.

**Survival Analysis**: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

**Genomics**: The systematic study of the complete DNA sequences (GENOME) of organisms.

**African Americans**: Persons living in the United States having origins in any of the black groups of Africa.

**Hospitals**: Institutions with an organized medical staff which provide medical care to patients.

**Health Knowledge, Attitudes, Practice**: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).

**Odds Ratio**: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.

**Absenteeism**: Chronic absence from work or other duty.

**Patient Admission**: The process of accepting patients. The concept includes patients accepted for medical and nursing care in a hospital or other health care institution.

**Entropy**: The measure of that part of the heat or energy of a system which is not available to perform work. Entropy increases in all natural (spontaneous and irreversible) processes. (From Dorland, 28th ed)

**Image Enhancement**: Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.

**Urban Population**: The inhabitants of a city or town, including metropolitan areas and suburban areas.

**Pedigree**: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.

**Hispanic Americans**: Persons living in the United States of Mexican (MEXICAN AMERICANS), Puerto Rican, Cuban, Central or South American, or other Spanish culture or origin. The concept does not include Brazilian Americans or Portuguese Americans.

**Breast Neoplasms**: Tumors or cancer of the human BREAST.

**Computer Graphics**: The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.

**Population Growth**: Increase, over a specific period of time, in the number of individuals living in a country or region.

**Contrast Sensitivity**: The ability to detect sharp boundaries (stimuli) and to detect slight changes in luminance at regions without distinct contours. Psychophysical measurements of this visual function are used to evaluate visual acuity and to detect eye disease.

**Rural Population**: The inhabitants of rural areas or of small towns classified as rural.

**Discriminant Analysis**: A statistical analytic technique used with discrete dependent variables, concerned with separating sets of observed values and allocating new values. It is sometimes used instead of regression analysis.

**Outcome Assessment (Health Care)**: Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).

**State Medicine**: A system of medical care regulated, controlled and financed by the government, in which the government assumes responsibility for the health needs of the population.

**Evolution, Molecular**: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.

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#### **Statistics** in Category: Terrorism

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**Regularized canonical correlation analysis**: Regularized canonical correlation analysis is a way of using ridge regression to solve the singularity problem in the cross-covariance matrices of canonical correlation analysis. By converting \operatorname{cov}(X, X) and \operatorname{cov}(Y, Y) into \operatorname{cov}(X, X) + \lambda I_X and \operatorname{cov}(Y, Y) + \lambda I_Y, it ensures that the above matrices will have reliable inverses.

**Vital statistics (government records)**: Vital statistics are statistics on live births, deaths, fetal deaths, marriages and divorces. The most common way of collecting information on these events is through civil registration, an administrative system used by governments to record vital events which occur in their populations (see Box 1).

**Inverse probability weighting**: Inverse probability weighting is a statistical technique for calculating statistics standardized to a population different from that in which the data was collected. Study designs with a disparate sampling population and population of target inference (target population) are common in application.

**Generalizability theory**: Generalizability theory, or G Theory, is a statistical framework for conceptualizing, investigating, and designing reliable observations. It is used to determine the reliability (i.

**Clonal Selection Algorithm**: In artificial immune systems, Clonal selection algorithms are a class of algorithms inspired by the clonal selection theory of acquired immunity that explains how B and T lymphocytes improve their response to antigens over time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody interactions, reproduction is inspired by cell division, and variation is inspired by somatic hypermutation.

**Interval boundary element method**: Interval boundary element method is classical boundary element method with the interval parameters.

**List of Parliamentary constituencies in Kent**: The ceremonial county of Kent,

**Certificate of relief from disabilities**: A Certificate of relief from disabilities is issued by a state of the United States of America to a person who has committed a felony or misdemeanor but has subsequently shown that he or she has been rehabilitated. The closely related "Certificate of good conduct" is given to a person who has committed two or more felonies and has demonstrated rehabilitation.

**Geographical cluster**: A geographical cluster is a localised anomaly, usually an excess of something given the distribution or variation of something else. Often it is considered as an incidence rate that is unusual in that there is more of some variable than might be expected.

**Mac OS X Server 1.0**

**Mortality rate**: Mortality rate, or death rate, is a measure of the number of deaths (in general, or due to a specific cause) in a particular population, scaled to the size of that population, per unit of time. Mortality rate is typically expressed in units of deaths per 1,000 individuals per year; thus, a mortality rate of 9.

**Decoding methods**: In coding theory, decoding is the process of translating received messages into codewords of a given code. There have been many common methods of mapping messages to codewords.

**A-scan ultrasound biometry**: A-scan ultrasound biometry, commonly referred to as an A-scan, is routine type of diagnostic test used in ophthalmology. The A-scan provides data on the length of the eye, which is a major determinant in common sight disorders.

**Monte Carlo methods for option pricing**: In mathematical finance, a Monte Carlo option model uses Monte Carlo methods Although the term 'Monte Carlo method' was coined by Stanislaw Ulam in the 1940s, some trace such methods to the 18th century French naturalist Buffon, and a question he asked about the results of dropping a needle randomly on a striped floor or table. See Buffon's needle.

**Biostatistics (journal)**: Biostatistics is a peer-reviewed scientific journal covering biostatistics, that is, statistics for biological and medical research. The journals that had cited Biostatistics the most by 2008Journal Citation Reports 2008, Science Edition were Biometrics, Journal of the American Statistical Association, Biometrika, Statistics in Medicine, and Journal of the Royal Statistical Society, Series B.

**Negative probability**: The probability of the outcome of an experiment is never negative, but quasiprobability distributions can be defined that allow a negative probability for some events. These distributions may apply to unobservable events or conditional probabilities.

**Assay sensitivity**: Assay sensitivity is a property of a clinical trial defined as the ability of a trial to distinguish an effective treatment from a less effective or ineffective intervention. Without assay sensitivity, a trial is not internally valid and is not capable of comparing the efficacy of two interventions.

**Closed-ended question**: A closed-ended question is a question format that limits respondents with a list of answer choices from which they must choose to answer the question.Dillman D.

**Hyperparameter**: In Bayesian statistics, a hyperparameter is a parameter of a prior distribution; the term is used to distinguish them from parameters of the model for the underlying system under analysis.

**QRISK**: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.

**Red Moss, Greater Manchester**: Red Moss is a wetland mossland in Greater Manchester, located south of Horwich and east of Blackrod. (Grid Reference ).

**Age adjustment**: In epidemiology and demography, age adjustment, also called age standardization, is a technique used to allow populations to be compared when the age profiles of the populations are quite different.

**Temporal analysis of products**: Temporal Analysis of Products (TAP), (TAP-2), (TAP-3) is an experimental technique for studying

**Incidence (epidemiology)**: Incidence is a measure of the probability of occurrence of a given medical condition in a population within a specified period of time. Although sometimes loosely expressed simply as the number of new cases during some time period, it is better expressed as a proportion or a rate with a denominator.

**Disease registry**: Disease or patient registries are collections of secondary data related to patients with a specific diagnosis, condition, or procedure, and they play an important role in post marketing surveillance of pharmaceuticals. Registries are different from indexes in that they contain more extensive data.

**Proportional reporting ratio**: The proportional reporting ratio (PRR) is a statistic that is used to summarize the extent to which a particular adverse event is reported for individuals taking a specific drug, compared to the frequency at which the same adverse event is reported for patients taking some other drug (or who are taking any drug in a specified class of drugs). The PRR will typically be calculated using a surveillance database in which reports of adverse events from a variety of drugs are recorded.

**Canadian Organ Replacement Registry**: The Canadian Organ Replacement Registry CORR is a health organisation was started by Canadian nephrologists and kidney transplant surgeons in 1985 in order to develop the care of patients with renal failure. In the early 1990s data on liver and heart transplantation were added to the registry.

**Regression dilution**: Regression dilution, also known as regression attenuation, is the biasing of the regression slope towards zero (or the underestimation of its absolute value), caused by errors in the independent variable.

**Panmixia**: Panmixia (or panmixis) means random mating.King C and Stanfield W.

**PSI Protein Classifier**: PSI Protein Classifier is a program generalizing the results of both successive and independent iterations of the PSI-BLAST program. PSI Protein Classifier determines belonging of the found by PSI-BLAST proteins to the known families.

**National Center for Injury Prevention and Control**: The U.S.

**List of geographic information systems software**: GIS software encompasses a broad range of applications which involve the use of a combination of digital maps and georeferenced data. GIS software can be sorted into different categories.

**List of poisonings**: This is a list of poisonings in chronological order of victim. It also includes confirmed attempted and fictional poisonings.

**Genetic linkage**: Genetic linkage is the tendency of alleles that are located close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Genes whose loci are nearer to each other are less likely to be separated onto different chromatids during chromosomal crossover, and are therefore said to be genetically linked.

**List of U.S. states by life expectancy**: This article presents a list of United States states sorted by their life expectancy at birth and by race/ethnicity in every state where the population of that racial or ethnic group is sufficiently large for robust estimates. The data is taken from the Measure of America's third national human development report, The Measure of America 2013–2014 width="25%" align="center" |

**Disequilibrium (medicine)**: Disequilibrium}}

**International Statistical Classification of Diseases and Related Health Problems**: The International Statistical Classification of Diseases and Related Health Problems, usually called by the short-form name International Classification of Diseases (ICD), is the international "standard diagnostic tool for epidemiology, health management and clinical purposes". The ICD is maintained by the World Health Organization (WHO), the directing and coordinating authority for health within the United Nations System.

**Information bias (epidemiology)**: Information bias}}

**Buckhorn Island State Park**

**Von Neumann regular ring**: In mathematics, a von Neumann regular ring is a ring R such that for every a in R there exists an x in R such that . To avoid the possible confusion with the regular rings and regular local rings of commutative algebra (which are unrelated notions), von Neumann regular rings are also called absolutely flat rings, because these rings are characterized by the fact that every left module is flat.

**STO-nG basis sets**: STO-nG basis sets are minimal basis sets, where n primitive Gaussian orbitals are fitted to a single Slater-type orbital (STO). n originally took the values 2 - 6.

**Health geography**: Health geography is the application of geographical information, perspectives, and methods to the study of health, disease, and health care.

**Fluorescence anisotropy**: Fluorescence anisotropy is the phenomenon where the light emitted by a fluorophore has unequal intensities along different axes of polarization. Early pioneers in the field include Aleksander Jablonski, Gregorio Weber,Weber, G.

**North Wales Narrow Gauge Railways**

**Global Risks Report**: The Global Risks Report is an annual study published by the World Economic Forum ahead of the Forum’s Annual Meeting in Davos, Switzerland. Based on the work of the Global Risk Network, the report describes changes occurring in the global risks landscape from year to year and identifies the global risks that could play a critical role in the upcoming year.

**Population stratification**: Population stratification is the presence of a systematic difference in allele frequencies between subpopulations in a population possibly due to different ancestry, especially in the context of association studies. Population stratification is also referred to as population structure, in this context.

**Genetic variation**: right|thumb

**Chromosome regions**

**Epidemiological method**: The science of epidemiology has matured significantly from the times of Hippocrates and John Snow. The techniques for gathering and analyzing epidemiological data vary depending on the type of disease being monitored but each study will have overarching similarities.

**Prenatal nutrition**: Nutrition and weight management before and during :pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life.

**Internet organizations**: This is a list of Internet organizations, or organizations that play or played a key role in the evolution of the Internet by developing recommendations, standards, and technology; deploying infrastructure and services; and addressing other major issues.

**Doob decomposition theorem**: In the theory of stochastic processes in discrete time, a part of the mathematical theory of probability, the Doob decomposition theorem gives a unique decomposition of every adapted and integrable stochastic process as the sum of a martingale and a predictable process (or "drift") starting at zero. The theorem was proved by and is named for Joseph L.

**National Cancer Research Institute**: The National Cancer Research Institute (NCRI) is a UK-wide partnership between cancer research funders, which promotes collaboration in cancer research. Its member organizations work together to maximize the value and benefit of cancer research for the benefit of patients and the public.

**CASY cell counting technology**: CASY technology is an electric field multi-channel cell counting system. It was first marketed by Schärfe System GmbH in 1987 under the name CASY1.

**Image fusion**: In computer vision, Multisensor Image fusion is the process of combining relevant information from two or more images into a single image.Haghighat, M.

**Matrix model**: == Mathematics and physics ==