Siblings: Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)Sibling Relations: Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies.Nuclear Family: A family composed of spouses and their children.Family Health: The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.Birth Order: The sequence in which children are born into the family.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Family: A social group consisting of parents or parent substitutes and children.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Histocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Consanguinity: The magnitude of INBREEDING in humans.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Family Characteristics: Size and composition of the family.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Diseases in Twins: Disorders affecting TWINS, one or both, at any age.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Parents: Persons functioning as natural, adoptive, or substitute parents. The heading includes the concept of parenthood as well as preparation for becoming a parent.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Adoption: Voluntary acceptance of a child of other parents to be as one's own child, usually with legal confirmation.Endophenotypes: Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Twins, Monozygotic: Two off-spring from the same PREGNANCY. They are from a single fertilized OVUM that split into two EMBRYOS. Such twins are usually genetically identical and of the same sex.Twins, Dizygotic: Two offspring from the same PREGNANCY. They are from two OVA, fertilized at about the same time by two SPERMATOZOA. Such twins are genetically distinct and can be of different sexes.Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.Infant, Newborn: An infant during the first month after birth.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Bereavement: Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.Birth Intervals: The lengths of intervals between births to women in the population.Genes, Recessive: Genes that influence the PHENOTYPE only in the homozygous state.Homozygote: An individual in which both alleles at a given locus are identical.Twins: Two individuals derived from two FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother. Twins are either monozygotic (TWINS, MONOZYGOTIC) or dizygotic (TWINS, DIZYGOTIC).Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.Parent-Child Relations: The interactions between parent and child.Only Child: Child who has no siblings.Integrin-Binding Sialoprotein: A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.SwedenChromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Social Environment: The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Survivors: Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Lod Score: The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Family Relations: Behavioral, psychological, and social relations among various members of the nuclear family and the extended family.

*  My Family Found Me - Page 2 - Reece's Rainbow Down Syndrome Adoption Grant Foundation

... and Allie can be adopted as a sibling group of 3 and Vallie and Nellie can be adopted as a sibling group of 2. When asked by ... 5 siblings #1-50 Mark - Age: 6 Diagnosis: speech delays; mild cognitive delay. Ellie - Age: 10 Diagnosis: mild cognitive delays ... This sibling group was raised by their mother until her death in early 2014. At that time, they were placed in a group home due ... She has her own foster parents and siblings and received much love from them. She is growing healthy and happy. Currently Mae ...

*  Are Support Groups Helpful For Siblings? Video - ABC News

Sometimes siblings can be afraid of aggression from their sibling. They may at times have difficulties getting in a caretaking ... One common problem are when siblings are jealous about the time required, that parents need to spend with a child with an ... role, where they try to do adult-level cares for their sibling, or taking care of stressed parents. ... It's very common for siblings to have difficulties over the course of time. ...

*  SAGE Reference - Siblings of Ill Children

"Siblings of Ill Children." In Encyclopedia of Family Health, edited by Martha Craft-Rosenberg and Shelley-Rae Pehler, 959-963. ... "Siblings of Ill Children." Encyclopedia of Family Health. Eds. Martha Craft-Rosenberg and Shelley-Rae Pehler. Vol. 2. Thousand ... "Siblings of Ill Children." In Encyclopedia of Family Health, edited by Martha Craft-Rosenberg and Shelley-Rae Pehler, 959-963. ... "Siblings of Ill Children." Encyclopedia of Family Health. Eds. Martha Craft-Rosenberg and Shelley-Rae Pehler. Vol. 2. Thousand ...

*  Caring for Siblings of Seriously Ill Children

By being aware of what healthy siblings are going through and taking a few steps to make things a little easier for them, ... Caring for Siblings of Seriously Ill Children. Resources. Please Note: By clicking a link to any resource listed on this page, ...

*  siblings : NPR


*  siblings | Josh Montague | Flickr

Taken on May 27, 2011 ...

*  Tagmash: siblings, -children | LibraryThing

Tagmash: siblings, -children. Extensive automated querying has forced to us to close tagmash to users who are not signed in. ..., -children

*  Tagmash: dolls, siblings | LibraryThing

Tagmash: dolls, siblings. Nobody has made this tagmash before. Unfortunately, this means you have to wait while it's calculated ..., siblings

*  Soil siblings

My soil siblings - Perry; his paragon of a wife; my amazing, artistic, best friend of two decades who gave me free reign in her ...

*  Siblings Newsletter Archive

BellaOnline's Siblings Editor. October 2 2008 Siblings Newsletter. Here's the latest article from the Siblings site at ... Unsubscribe from the Siblings Newsletter Online Newsletter Archive for Siblings Site Master List of BellaOnline Newsletters ... Please visit for even more great content about Siblings.. To participate in free, fun online ... Nina Guilbeau, Siblings Editor One of hundreds of sites at ... 12:27:59 PM

*  Siblings Untitled 04

It's like a collection of extra scenes from 'Don't Sleep Robby', except a LOT weirder

*  Kids Talk About: Siblings (Video)

What do kids think about their brothers and sisters? Hear what they had to say.

*  Sibling Rivalry

... conflict between siblings is very common. Here's how to help your kids get along. ... Sibling Rivalry. Resources. Please Note: By clicking a link to any resource listed on this page, you will be leaving this site. ...

*  Siblings of Twins | POPSUGAR Moms

Siblings of Twins. Being the Single Sibling of Twins Can Be Doubly Difficult September 24, 2010 by babysugar ... But where does another sibling fit into the mix? The extra brother or sister to a set of twins may feel left out when it comes ... Does a brother or sister of twins have as close of a relationship with twin siblings as he or she would if the twosome had been ... Sometimes the parents don't understand why the single sibling wants to have friends over a lot, but they don't get that the ...

*  It's National Siblings Day -

April 10 is the officially recognized holiday of National Siblings Day. ... Claudia Evart, founder of the Siblings Day Foundation, wanted to make it a holiday after both of her siblings passed away. ... Happy National Siblings Day!. Today would be a good day to call a brother or a sister. ... The idea behind it is similar to Father's Day or Mother's Day, only siblings get a little more attention and appreciation. ...

*  Sibling Rivalry

... What you can do to ensure family harmony, now and for generations to come.. by Rebbetzin Feige Twerski ... We were five siblings at the time. We were temporarily housed in a hotel for refugees in Manhattan. We were objects of interest ... Problems of sibling rivalry and hatred between brothers do not suddenly appear out of nowhere in adulthood. It does not happen ... He will stop at nothing to guard and protect his territory, even at the cost of the sibling relationship. If we don't want ...

*  Michael Jackson's siblings attack estate executors - CNN

Janet Jackson and four of her siblings sent a scathing letter to the men who control Michael Jackson's estate, accusing them of ... The siblings also attacked Sanders, Katherine Jackson's manager, Lowell Henry, and adviser Trent Jackson for discouraging her ... Janet Jackson and four of her siblings sent a scathing letter to the men who control Michael Jackson's estate, accusing them of ... Siblings: "Heartless pursuit of wealth, fame and power is at the expense of our family" ...

*  Siblings FAQ and Information Archive

Bullying Between Siblings. Bullying can sometimes be a cry for help. Steps you can take when both victim and aggressor live in ...

*  Sibling Rivalry - Wikipedia

Sibling Rivalry è il dodicesimo album discografico in studio del gruppo musicale rock statunitense The Doobie Brothers, ... Sibling Rivalry, su AllMusic, All Media Network.. ...

*  Adult Siblings' Parenting Differences - Siblings

Here are six tips to keep the differences in parenting skills from adding to adult sibling rivalry. - Adult Siblings' Parenting ... Adult sibling comparisons often include children and child rearing methods. ... BellaOnline's Siblings Editor. Adult Siblings' Parenting Differences Comparing or critiquing the parenting skills of brothers ... The sibling issues that will arise from this situation will not be diet and nutrition, but trust and respect. Communication ...

*  Urban Dictionary: west virginia siblings

There aren't any definitions for west virginia siblings yet.. Can you define it?. ... virginia siblings

*  The Siblings Trouble by Eduardo Baraf - Kickstarter

Eduardo Baraf is raising funds for The Siblings Trouble on Kickstarter! Go on an epic, 30-minute adventure in this card-driven ... Keep up on The Siblings Trouble - Follow The Siblings Trouble on Facebook. - Follow Me (@ebaraf) on Twitter ... The Nerd's Table: The Siblings Trouble Review. - Back it! on DFW Nerd Night: Ed Interview. - Docking Bay 94: The Siblings ... The Siblings Trouble on - The Siblings Trouble on ...

*  Tagmash: anorexia, fiction, siblings, young adult | LibraryThing

Tagmash: anorexia, fiction, siblings, young adult. Nobody has made this tagmash before. Unfortunately, this means you have to ..., fiction, siblings, young adult

*  Special needs for special siblings - Baltimore Sun

The siblings of developmentally disabled people often have the longest relationships supporting their special needs brothers ... Some siblings feel pressure to be high achievers to balance the scale. Many yearn for the friendship of a 'normal' sibling ... As parent caregivers get older, a sibling's role takes on new importance, and underscores the value of nurturing the siblings' ... that siblings are part of the family,' said Don Meyer, director of the Seattle-based Sibling Support Project (siblingsupport. ...

I Do You: "I Do You" is a song by the American sibling group, The Jets. It was written by Stephen Bray (who is perhaps best known for his frequent collaborations with Madonna during the 1980s) and Linda Mallah.Pedigree chart: A pedigree chart is a diagram that shows the occurrence and appearance or phenotypes of a particular gene or organism and its ancestors from one generation to the next,pedigree chart Genealogy Glossary -, a part of The New York Times Company.HLA B7-DR15-DQ6Graft-versus-host diseaseBone Marrow Transplantation (journal): Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans. It is published monthly by the Nature Publishing Group.Cousin couple: A cousin couple is a pair of cousins who are involved in a romantic or sexual relationship.Genetic linkage: Genetic linkage is the tendency of alleles that are located close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction. Genes whose loci are nearer to each other are less likely to be separated onto different chromatids during chromosomal crossover, and are therefore said to be genetically linked.Phenotype microarray: The phenotype microarray approach is a technology for high-throughput phenotyping of cells.QRISK: QRISK2 (the most recent version of QRISK) is a prediction algorithm for cardiovascular disease (CVD) that uses traditional risk factors (age, systolic blood pressure, smoking status and ratio of total serum cholesterol to high-density lipoprotein cholesterol) together with body mass index, ethnicity, measures of deprivation, family history, chronic kidney disease, rheumatoid arthritis, atrial fibrillation, diabetes mellitus, and antihypertensive treatment.Hematopoietic stem cell transplantationThe Otwell Twins: The Otwell Twins are an American singing duo made up of identical twin brothers Roger and David, born August 2, 1956, in Tulia, Texas. They are best known as members of The Lawrence Welk Show from 1977-1982.Parent structure: In IUPAC nomenclature, a parent structure, parent compound, parent name or simply parent is the denotation for a compound consisting of an unbranched chain of skeletal atoms (not necessarily carbon), or consisting of an unsubstituted monocyclic or polycyclic ring system.Closed adoptionMonochorionic twinsHeritability: Heritability is a statistic used in breeding and genetics works that estimates how much variation in a phenotypic trait in a population is due to genetic variation among individuals in that population. It is calculated with the following equation (for broad-sense heritability): H^2 = VG/VP.Congenital hypoplastic anemiaHematological Cancer Research Investment and Education Act: The Hematological Cancer Research Investment and Education Act of 2001 (P.L.OpsismodysplasiaTwin reversed arterial perfusionFocus on Autism and Other Developmental Disabilities: Focus on Autism and Other Developmental Disabilities is a peer-reviewed academic journal covering the field of special education. The editors-in-chief are Alisa K.Religion and schizophrenia: == Background ==Henry Dalzell, 8th Earl of Carnwath: Henry Arthur Hew Dalzell, 8th Earl of Carnwath was born 12 April 1858 in Baden-Wurttemberg, the only child of Thomas Henry Dalzell, 7th Earl of Carnwath and Isabella Eliza Wilmot. He succeeded to his father's titles upon the latter's death in 1867.Bone sialoprotein: Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum.Climate change in Sweden: The issue of climate change has received significant public and political attention in Sweden and the mitigation of its effects has been high on the agenda of the two latest Governments of Sweden, the previous Cabinet of Göran Persson (-2006) and the current Cabinet of Fredrik Reinfeldt (2006-). Sweden aims for an energy supply system with zero net atmospheric greenhouse gas emissions by 2050.Chromosome regionsSilent mutation: Silent mutations are mutations in DNA that do not significantly alter the phenotype of the organism in which they occur. Silent mutations can occur in non-coding regions (outside of genes or within introns), or they may occur within exons.Survivor Type: "Survivor Type" is a short story by Stephen King, first published in the 1982 horror anthology Terrors, edited by Charles L. Grant, and collected in King's 1985 collection Skeleton Crew.Infinite alleles model: The infinite alleles model is a mathematical model for calculating genetic mutations. The Japanese geneticist Motoo Kimura and American geneticist James F.Nested case-control study: A nested case control (NCC) study is a variation of a case-control study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest.Fasting, Feasting: Fasting, Feasting is a novel by Indian writer Anita Desai, first published in 1999 in Great Britain by Chatto and Windus. It was shortlisted for the Booker Prize for fiction in 1999.

(1/1632) The right to be treated against her will.

... My sister's inconsistent and intermittent treatment over the past eight years is largely a result of her own indecision and the inconsistencies of her abnormal mental state. The professionals who might have taken control of the situation as her health and functioning deteriorated have not done so and I must presume that they believe they cannot do so. I do not think her case is unique. There are many more people living in the community who are severely ill and are being deprived of treatment they need.  (+info)

(2/1632) Haematopoietic stem cell transplantation for thalassaemia major in Hong Kong: prognostic factors and outcome.

From August 1992 to August 1999, 44 patients received allogeneic haematopoietic stem cell transplantation in a single institution. The donors were HLA-identical siblings except for one who was a phenotypically matched father. Thirty-eight patients received bone marrow stem cells and the others received peripheral blood stem cells or umbilical cord blood (UCB). The mean age at transplant was 10.7+/-5.1 years, ranging from 1.8 to 21 years. Patients received busulphan (16 mg/kg) and cyclophosphamide (150 to 200 mg/kg) as conditioning, and antithymocyte globulin was given to 42 patients to prevent graft rejection. All had engraftment except a patient who received a UCB transplant. Four patients died from early treatment-related mortality, and one died from interstitial pneumonitis 3 months after transplant. Two patients developed secondary graft rejection and both received a second transplant. Thirty-eight patients survived and all except one were transfusion independent. The 5-year overall and event-free survival rates were 86% and 82%, respectively. By multivariate stepwise Cox proportional hazard analyses, severe veno-occlusive disease (VOD) of liver and Pesaro class 3 features were the significant factors associated with survival. Patients aged more than 11 years were more inclined to develop VOD. In conclusion, haematopoietic stem cell transplantation should be performed early if an HLA identical sibling is available.  (+info)

(3/1632) Healthy sibling donor anxiety and pain during bone marrow or peripheral blood stem cell harvesting for allogeneic transplantation: results of a randomised study.

This study reports the first comparison of healthy donor subjective well-being during two alternative procedures of hematopoietic stem cells harvesting for allogeneic transplantation. Among the 105 donors included between September 1996 and October 1998 in the SFGM French randomised trial aiming to compare allogeneic bone marrow (BM) transplantation and blood cell (BC) transplantation, 64 donors (33 in BC and 31 in BM groups) were relevant for the analysis. They had received a set of self-administered questionnaires to complete during the collection process, aiming to measure anxiety (assessed using the Spielberger's State-Trait Anxiety Inventory) and pain induced by the procedure (evaluated using a visual analogical scale). Results showed that no harvest procedure is free from pain even if none was more painful than the other. Levels of anxiety before the collection procedure were high in both groups and significantly so for BC donors. Although BC collection induces at least similar levels of pain and anxiety as does BM collection, they were of a different kind, and the short-term impact of G-CSF stimulation on the well-being of BC donors has to be taken into account in improving quality of care in the allogeneic setting.  (+info)

(4/1632) Myocarditis in sibling boxer puppies associated with Citrobacter koseri infection.

Two sibling Boxer puppies presented with severe suppurative myocarditis in the absence of additional disseminated suppurative foci. The identification of gram-negative bacteria within areas of myocarditis in both puppies and the pure growth of large numbers of Citrobacter koseri from the myocardial lesions in one of the dogs were consistent with a bacterial etiology. The fact that C. koseri is an opportunist pathogen suggested intercurrent immunosuppression. The finding of a concomitant bacterial myocarditis in two canine siblings is novel. The case is also unusual in that syncope could be related to the myocardial injury.  (+info)

(5/1632) Familial risk of preeclampsia in Newfoundland: a population-based study.

This study sought to quantify the familial risk of preeclampsia (proteinuric hypertension) in Newfoundland and to identify characteristics in probands that predict increased familial risk. Reviewed were 5173 obstetric charts from 10 hospitals, representing 99% of deliveries on the island of Newfoundland for a 1-yr period from April 1996 to March 1997; pregnancy-induced hypertension was diagnosed according to strict criteria. Family obstetric histories were obtained from identified probands with preeclampsia, and sisters and mothers of probands were interviewed. In addition, the obstetric charts from sisters and mothers were reviewed to identify preeclampsia. The incidence of preeclampsia in the population was 5.6% (n = 292), and in primiparous women it was 7.9%. Factors independently associated with increased risk of preeclampsia included primiparous delivery, multiple gestation, pregestational and gestational diabetes, maternal age of more than 35 yr, and region of the province. Of 330 sisters identified, 217 had 445 pregnancies, with 331 charts located for review. The incidence of preeclampsia (based on chart review) in 163 primiparous sisters was 20.2%. The relative risk of preeclampsia in primiparous sisters of probands with preeclampsia compared with primiparous women in the population was 2.6 (95% confidence interval, 1.8 to 3.6). Factors in probands independently associated with a higher risk of preeclampsia in sisters included at least 2+ proteinuria and region of the province. This population-based study, which used unbiased ascertainment and strict diagnostic criteria, demonstrated a significantly higher risk of preeclampsia in sisters of probands with preeclampsia, particularly when probands were defined by severity of preeclampsia and by geographic region.  (+info)

(6/1632) Genetic heterogeneity in schizophrenia II: conditional analyses of affected schizophrenia sibling pairs provide evidence for an interaction between markers on chromosome 8p and 14q.

Information from multiple genome scans and collaborative efforts suggests that schizophrenia is a heterogeneous, complex disorder with polygenic and environmental antecedents. In a previous paper we demonstrated that stratification of families on the basis of co-segregating phenotypes (psychotic affective disorders (PAD) and schizophrenia spectrum personality disorders (SSPD) in first-degree relatives of schizophrenic probands increased linkage evidence in the chromosome 8p21 region (D8S1771) among families with co-segregating SSPD. We have now applied a method of conditional analysis of sib-pairs affected with schizophrenia, examining shared alleles identical-by-descent (IBD) at multiple loci. The method yields enhanced evidence for linkage to the chromosome 8p21 region conditioned upon increased allele sharing at a chromosome 14 region. The method produces a more refined estimate of the putative disease locus on chromosome 8p21, narrowing the region from 18 cM (95% confidence interval) in our previous genome scan, to approximately 9.6 cM. We have also shown that the affected siblings sharing two alleles IBD at the chromosome 8p21 region and one allele IBD at the chromosome 14 region differ significantly in clinical symptoms from non-sharing affected siblings. Thus the analysis of allele sharing at a putative schizophrenia susceptibility locus conditioned on allele sharing at other loci provides another important method for dealing with heterogeneity.  (+info)

(7/1632) Reciprocal bone marrow transplantation between brother and sister.

A child with AML underwent allogeneic BMT from an HLA-identical sister donor. Prompt and stable triline-age engraftment occurred and after few months he returned to a normal life. Eight years later a primary NHL of bone developed in his sister. A partial remission was obtained by means of standard NHL treatment, but 3 months later rapid disease progression occurred with complete bone marrow invasion (ALL-L3). She was treated with a leukemia relapse protocol, obtaining a second partial remission. Unpurged bone marrow harvested from the brother, transplanted for AML 8 years earlier, was infused after conditioning with TBI and thiothepa. No GVHD prophylaxis was given. Neutrophil engraftment occurred by 14 days and platelet engraftment by 20 days after BMT. No acute GVHD was observed, but unexpectedly she developed skin and liver GVHD-like symptoms 80 days after BMT. Since the liver biopsy was suggestive of liver GVHD and in the absence of any other evidence as a possible cause of the hepatic damage, the patient started mycophenolate. Two months later serum hepatitis B markers were detectable.  (+info)

(8/1632) Vitamin D receptor gene polymorphism associates with graft-versus-host disease and survival in HLA-matched sibling allogeneic bone marrow transplantation.

We investigated the role of polymorphism of the vitamin D receptor (VDR) gene in HLA-matched sibling BMT for polymorphisms previously associated with human disease pathology. In intron 8 of the VDR gene, the B and A alleles of the BsmI and ApaI RFLPs were found to associate with reduced aGVHD when present in the patient's genotype. Logistic regression analysis demonstrated that patient VDR genotype, along with previously identified IL-10(-1064) and IFN-gamma genotype to be risk factors for severe acute GVHD. The A allele also associates with increased likelihood of death when present in the donor genotype (AA vs Aa or aa, hazard ratio 2.03, P = 0.0232). In patients who received increased prophylaxis with multi-agent therapy, patients whose graft was from a donor with an AA genotype had a substantially worse survival than patients whose graft was from a donor with a non-AA genotype (hazard ratio 12.93, P < 0.0001). Analysis of VDR genotype in prospective BMT recipients could indicate patients at risk of severe aGVHD. Analysis of VDR genotype in prospective BMT donors may identify individuals who have greater transplant-related mortality, and also allow appropriately restricted use of increased immunosuppressive prophylaxis.  (+info)


  • These studies pointed the way for human marrow grafting using HLA-matched sibling donors. (
  • The patients enrolled in this study will be those who lack matched sibling donors and therefore have no other option but to undergo bone marrow transplantation using matched but unrelated bone marrow or umbilical cord blood from the national marrow donor program registry. (