Origin of DNA damage in ejaculated human spermatozoa. (1/76)

The molecular basis of many forms of male infertility is poorly defined. One area of research that has been studied intensely is the integrity of the DNA in the nucleus of mature ejaculated spermatozoa. It has been shown that, in men with abnormal sperm parameters, the DNA is more likely to possess strand breaks. However, how and why this DNA damage originates in certain males and how it may influence the genetic project of a mature spermatozoon is unknown. Two theories have been proposed to describe the origin of this DNA damage in mature spermatozoa. The first arises from studies performed in animal models and is linked to the unique manner in which mammalian sperm chromatin is packaged, while the second attributes the nuclear DNA damage in mature spermatozoa to apoptosis. One of the factors implicated in sperm apoptosis is the cell surface protein, Fas. In this review, we discuss the possible origins of DNA damage in ejaculated human spermatozoa, how these spermatozoa arrive in the ejaculate of some men, and what consequences they may have if they succeed in their genetic project.  (+info)

Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation. (2/76)

The histone macroH2A1.2 has been implicated in X chromosome inactivation on the basis of its accumulation on the inactive X chromosome (Xi) of adult female mammals. We have established the timing of macroH2A1.2 association with the Xi relative to the onset of X-inactivation in differentiating murine embryonic stem (ES) cells using immuno-RNA fluorescence in situ hybridization (FISH). Before X-inactivation we observe a single macroH2A1.2-dense region in both undifferentiated XX and XY ES cells that does not colocalize with X inactive specific transcript (Xist) RNA, and thus appears not to associate with the X chromosome(s). This pattern persists through early stages of differentiation, up to day 7. Then the frequency of XY cells containing a macroH2A1.2-rich domain declines. In contrast, in XX cells there is a striking relocalization of macroH2A1.2 to the Xi. Relocalization occurs in a highly synchronized wave over a 2-d period, indicating a precisely regulated association. The timing of macroH2A1.2 accumulation on the Xi suggests it is not necessary for the initiation or propagation of random X-inactivation.  (+info)

Higher concentrations of histone macroH2A in the Barr body are correlated with higher nucleosome density. (3/76)

Histone macroH2A, which is a subtype of histone H2A, possesses a histone H2A-like portion fused to a relatively long non-histone portion. MacroH2A has been shown to associate preferentially with the inactive X chromosome [1]. To investigate the specificity of this association, the nuclear distribution of macroH2A was compared with that of regular core histones. In normal human female fibroblasts, all anti-histone antibodies that were tested (including anti-macroH2A antibody) preferentially labeled the inactive X chromosome. Moreover, when expressed as green fluorescent protein (GFP) fusions, both histone H2A and macroH2A were concentrated in the Barr body. These data clearly show the presence of a higher density of nucleosomes in the inactive X chromosome. Accordingly, the specificity of the macroH2A association with the inactive X chromosome should be reconsidered. While investigating the role of macroH2A, we found that the proximity of the non-histone region of macroH2A to a promoter could lead to a specific repression of transcription, suggesting that the incorporation of macroH2A into chromatin might help to establish the stable pattern of gene expression in differentiated cells.  (+info)

The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. (4/76)

To analyze the function of the chromosomal kinase JIL-1, we generated an allelic series of hypomorphic and null mutations. JIL-1 is an essential kinase for viability, and reduced levels of JIL-1 kinase activity lead to a global change in chromatin structure. In JIL-1 hypomorphs, euchromatic regions of polytene chromosomes are severely reduced and the chromosome arms condensed. This is correlated with decreased levels of histone H3 Ser10 phosphorylation. These levels can be restored by a JIL-1 transgene placing JIL-1 directly in the pathway mediating histone H3 phosphorylation. We propose a model where JIL-1 kinase activity is required for maintaining the structure of the more open chromatin regions that facilitate gene transcription.  (+info)

Identification of an autoimmune serum containing antibodies against the Barr body. (5/76)

Transcriptional inactivation of one X chromosome in mammalian female somatic cells leads to condensation of the inactive X chromosome into the heterochromatic sex chromatin, or Barr body. Little is known about the molecular composition and structure of the Barr body or the mechanisms leading to its formation in female nuclei. Because human sera from patients with autoimmune diseases often contain antibodies against a variety of cellular components, we reasoned that some autoimmune sera may contain antibodies against proteins associated with the Barr body. Therefore, we screened autoimmune sera by immunofluorescence of human fibroblasts and identified one serum that immunostained a distinct nuclear structure with a size and nuclear localization consistent with the Barr body. The number of these structures was consistent with the number of Barr bodies expected in diploid female fibroblasts containing two to five X chromosomes. Immunostaining with the serum followed by fluorescence in situ hybridization with a probe against XIST RNA demonstrated that the major fluorescent signal from the autoantibody colocalized with XIST RNA. Further analysis of the serum showed that it stains human metaphase chromosomes and a nuclear structure consistent with the inactive X in female mouse fibroblasts. However, it does not exhibit localization to a Barr body-like structure in female mouse embryonic stem cells or in cells from female mouse E7.5 embryos. The lack of staining of the inactive X in cells from female E7.5 embryos suggests the antigen(s) may be involved in X inactivation at a stage subsequent to initiation of X inactivation. This demonstration of an autoantibody recognizing an antigen(s) associated with the Barr body presents a strategy for identifying molecular components of the Barr body and examining the molecular basis of X inactivation.  (+info)

Micropenis associated with testicular agenesis. (6/76)

This paper describes 2 male infants who were born with sever micropenis and in whom testicular tissue could not be identified at surgery. HCG stimulation in one infant was not followed by a rise in plasma testosterone. It was decided that both cases would be best raised as females, despite their male chromosomal sex.  (+info)

A developmental study of girls with trisomy X. (7/76)

Development of 11 girls (ages 2-10 years) with 47,XXX karyotype identified in a newborn survey is compared with eight girls having a mosaic sex chromatin pattern and with the normal siblings of each group. Delay in early motor development and speech, a mild intellectual deficit, and disturbance in interpersonal relationships occurred in one-third of the index cases, a higher frequency than in the comparison groups. two-thirds were considered normal and adequately adjusted. No consistent phenotype was found.  (+info)

Human X-autosome translocations: differential inactivation of the X chromosome in a kindred with an X-9 translocation. (8/76)

A kindred with an X-autosome translocation and differential inactivation of the X chromosome is described. The phenotypically normal mother has a reciprocal translocation [46,X,rcp(X;9) (q11;q32)] while the daughter's karyotype is unbalanced [46,X,--X,+der(9),rcp(X;9) (q11;q32)mat], indicating adjacent-two type of segregation in the mother. In the mother's cells the normal X is late replicating, while in the daughter's cells almost the entire der(9) is late replicating, indicating the presence of autosomal inactivation. The daughter's abnormal phenotype can be explained by her sex chromosomal complement and the absence of effective trisomy 9. At this stage there is no simple explanation to account for all types of inactivation patterns encountered in the 14 balanced and 15 unbalanced cases of X-autosome translocations reported to date. Selection of X inactivation is not an inherent characteristic of the X chromosome per se, and it is not dependent on the direction of chromosomal exchange, as was suggested previously. Correlation of the phenotypic and cytogenetic features of these patients suggests a pattern of X and autosomal inactivation consistent with the least amount of genotypic and phenotypic imbalance in most cases. The data are most consistent with random X inactivation followed by selection of the most viable cell line.  (+info)

*Mary F. Lyon

Lyon, M. F. (1962). "Sex chromatin and gene action in the mammalian X-chromosome". American Journal of Human Genetics. 14: 135- ... In 1997 she also received the Amory Prize, for genetic discoveries relating to mammalian sex chromosomes. In 2004 she was ...

*Nuclear sexing

A minimum of 30 percent of sex chromatin indicates genetic female sex. Barr, M. L.; Bertram, E. G. (1949-04-30). "A ... Nuclear sexing is a technique for genetic sex determination in those species where XX chromosome pair is present. Nuclear ... sexing can be done by identifying Barr body, a drumstick like appendage located in the rim of the nucleus in somatic cells. ...

*Dosage compensation

Cock A.G. (1964). "Dosage compensation and sex-chromatin in non-mammals". Genet Res Camb. 5: 354-365. doi:10.1017/ ... This system of sex determination is unique, because there is no male specific chromosome, as is the case in XX/XY sex ... Across species, different sexes are often characterized by different types and numbers of sex chromosomes. In order to account ... Ohno, Susumu (1959). "Sex chromosomes and sex-linked genes". Teratology. 4: 111. doi:10.1002/tera.1420040116. Lyon, M.F. (1961 ...

*1985 Summer Universiade

The sex chromatin test was used at these games to decide on participants' gender; Spanish hurdler Maria José Martínez-Patiño ... "The Humiliating Practice of Sex-Testing Female Athletes". New York Times. Ljungqvist, A. (2008-04-15). "Gender Verification". ...

*Susumu Ohno

ISBN 0-04-575015-7. Ohno S, Kaplan WD, Kinosita R (1959). "Formation of the sex chromatin by a single X-chromosome in liver ... Ohno S (1967). Sex Chromosomes and Sex-Linked Genes. Berlin, New York: Springer-Verlag Wycoff, Mick (2008). "Art as Science ...

*X-inactivation

CS1 maint: Multiple names: authors list (link) Ohno S, Kaplan WD, Kinosita R (1959). "Formation of the sex chromatin by a ... unlike the majority of genes along the sex chromosomes. Since individuals of either sex will receive two copies of every gene ... These regions are termed pseudoautosomal regions, as individuals of either sex will receive two copies of every gene in these ... Examining normal tissues and tumors from females heterozygous for isoenzymes of the sex-linked G6PD gene demonstrated that ...

*Biomarker

Basu, P. K.; Miller, I.; Ormsby, H. L. (1960-03-01). "Sex chromatin as a biologic cell marker in the study of the fate of ...

*Maria José Martínez-Patiño

The sex chromatin test was, at the time, the first step in the gender verification process, and not intended to provide a ... she failed the sex chromatin test in 1985, and thus was ruled ineligible to participate in women's athletics. The test was ... Wiesemann, Claudia (2011). "Is there a right not to know one's sex? The ethics of 'gender verification' in women's sports ... Ruth Padawer (June 28, 2016). "The Humiliating Practice of Sex-Testing Female Athletes". New York Times. Bardin, Jon (30 July ...

*Harry Klinefelter

Eighty percent of these patients have positive sex chromatin, and their karyotypes may vary widely, and with many mosaics. The ... Although these patients have positive female sex chromatin, they are phenotypic males and should never be considered otherwise ... or were chromatin positive. A few years later, Jacobs and Strong found that these chromatin-positive patients had 47 ... Anaphase lag might result in a gamete losing a sex chromosome; a chromosome lags and is not incorporated in the new cell in the ...

*List of MeSH codes (A11)

... sex chromosomes MeSH A11.284.187.865.800 - sex chromatin MeSH A11.284.187.865.982 - x chromosome MeSH A11.284.187.865.982.500 ... sex chromatin MeSH A11.284.430.106.279.345.190.160.180.625 - nucleosomes MeSH A11.284.430.106.279.345.190.160.650 - nucleolus ... sex MeSH A11.284.180.700 - pseudopodia MeSH A11.284.183.200 - cell wall skeleton MeSH A11.284.187.167 - chromosomes, archaeal ... chromatin MeSH A11.284.430.106.279.345.190.160.180.270 - euchromatin MeSH A11.284.430.106.279.345.190.160.180.383 - ...

*List of MeSH codes (G14)

... sex chromatin MeSH G14.162.865.982 --- x chromosome MeSH G14.162.865.982.500 --- chromosomes, human, x MeSH G14.162.865.983 ... sex chromatin MeSH G14.160.180.625 --- nucleosomes MeSH G14.162.178.170 --- chromosomes, artificial, bacterial MeSH G14.162. ...

*Klinefelter syndrome

... determination of the sex chromatin, and prenatally via chorionic villus sampling or amniocentesis. A 2002 literature review of ... Nondisjunction will occur when sister chromatids on the sex chromosome, in this case an X and an X, fail to separate. (meiosis ... MACLEAN N, HARNDEN DG, COURT BROWN WM; Harnden; Court Brown (Aug 1961). "Abnormalities of sex chromosome constitution in ... Linden MG, Bender BG, Robinson A (1995). "Sex chromosome tetrasomy and pentasomy". Pediatrics. 96 (4 Pt 1): 672-682. PMID ...

*XYY syndrome

... sex chromatin bodies was not developed until 1970, a decade after the first reported sex chromosome aneuploidy. The first ... Screening for those X chromosome aneuploidies was possible by noting the presence or absence of "female" sex chromatin bodies ( ... sex chromatin bodies in the nuclei of interphase cells in buccal smears treated with quinacrine dihydrochloride, which could be ... In the wake of the establishment of the normal number of human chromosomes, 47,XYY was the last of the common sex chromosome ...

*ASXL1

1998). "The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group ... In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of ... "A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11". Gene. 306: 115-26. doi:10.1016 ... The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the ...

*Ridge (biology)

The authors reasoned this was due to the low rate of chromosomal rearrangements of sex chromosomes. Open chromatin regions are ... When the chromatin of one gene is opened, the chromatin of the adjacent genes is also until this modification meets a boundary ... Chromatin consists of the DNA strand and histones that are attached to the DNA. Regions were chromatin is very tightly packed ... Chromatin which consists of functional genes is often an open structure were the DNA is accessible. However, most of the genes ...

*HORMAD1

... a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control ... in both sexes (By similarity) GRCh38: Ensembl release 89: ENSG00000143452 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...

*M33 (gene)

1998) indicates that homozygous M33-mutant mice represent the first case in which male-to-female gonadal sex reversal results ... Polycomb genes in Drosophila mediate changes in higher-order chromatin structure to maintain the repressed state of ... Ono, Makoto; Harley, Vincent R. (2013-02-01). "Disorders of sex development: new genes, new concepts". Nature Reviews. ... "Male-to-female sex reversal in M33 mutant mice". Nature. 393 (6686): 688-692. doi:10.1038/31482. ISSN 0028-0836. PMID 9641679 ...

*Testis-determining factor

... and identifying the genes that transcription factors act on using chromatin immunoprecipitation. Y chromosome Sex-determination ... Monotremes lack SRY and some of their sex chromosomes share homology with bird sex chromosomes. SRY is a quickly evolving gene ... GeneReviews/NCBI/NIH/UW entry on 46,XX Testicular Disorder of Sex Development OMIM entries on 46,XX Testicular Disorder of Sex ... Müller J, Schwartz M, Skakkebaek NE (July 1992). "Analysis of the sex-determining region of the Y chromosome (SRY) in sex ...

*Paul Schedl

On the genomic level, his lab has uncovered the mechanisms of chromatin regulation by the Polycomb and trithorax group genes. ... he made discoveries in the regulation of alternative splicing of the sex determination gene, Sxl. At the level of translational ...

*Plasmodium carmelinoi

The sex ratio was 1 male to 2.2 females. This parasite is found in Brazil. Not known. P. carmelinoi infects the teiid lizard ( ... micrometres and stain an over-all pink colour due to the dispersed nuclear chromatin. Macrogametocytes measure 5.7 (4.4 - 5.9) ...

*Meiotic recombination checkpoint

Meiotic sex chromosome inactivation only happens in male, which may partially be the reason why only Spo11 mutant spermatocytes ... "A High Incidence of Meiotic Silencing of Unsynapsed Chromatin Is Not Associated with Substantial Pachytene Loss in Heterozygous ... Some other studies also drew sex body formation into attention, and the signaling could be either structure based or ... Under this cascade, failure to synapse will maintain the gene expression from sex chromosomes and some products may inhibit ...

*BRDT

Homozygous mutant males were sub-fertile and both sexes had a decreased number of lumbar and sacral vertebrae. BET inhibitors ... 2003). "Acetylation-Dependent Chromatin Reorganization by BRDT, a Testis-Specific Bromodomain-Containing Protein". Mol. Cell. ... such as JQ1 block the region of BRDT responsible for chromatin binding, and cause a reversible reduction of sperm production, ... could be explained by considering Brdt's functions as a driver of testis-specific gene expression and post-meiotic chromatin ...

*Genetics

2000). "Sex chromosomes and sex-linked inheritance". An Introduction to Genetic Analysis (7th ed.). New York: W. H. Freeman. ... forming a material called chromatin; in eukaryotes, chromatin is usually composed of nucleosomes, segments of DNA wound around ... In 1911, Thomas Hunt Morgan argued that genes are on chromosomes, based on observations of a sex-linked white eye mutation in ... Many species have so-called sex chromosomes that determine the gender of each organism. In humans and many other animals, the Y ...

*Dextroamphetamine

Blum K, Werner T, Carnes S, Carnes P, Bowirrat A, Giordano J, Oscar-Berman M, Gold M (March 2012). "Sex, drugs, and rock 'n' ... Renthal W, Nestler EJ (September 2009). "Chromatin regulation in drug addiction and depression". Dialogues Clin. Neurosci. 11 ( ... These sex addictions are associated with a dopamine dysregulation syndrome which occurs in some patients taking dopaminergic ... Zhou Y, Zhao M, Zhou C, Li R (July 2015). "Sex differences in drug addiction and response to exercise intervention: From human ...

*Prophase

Sex (X and Y) chromosomes do not fully synapse because only a small region of the chromosomes are homologous. The nucleolus ... Chromatin has condensed enough that chromosomes can now be resolved in microscopy. Structures called recombination nodules form ... Each chromosome is in a haploid state and consists of two sister chromatids; however, the chromatin of the sister chromatids is ... Prophase I occurs at different speeds dependent on species and sex. Many species arrest meiosis in diplotene of prophase I ...

*Transgenerational stress inheritance

Chromatin remodeling in rodent offspring and altered gene expression within the limbic brain regions that may contribute to ... Hodes GE, Walker DM, Labonté B, Nestler EJ, Russo SJ (January 2017). "Understanding the epigenetic basis of sex differences in ...
Barr and Bertram described a small body in the nuclei of normal females composed of DNA. This was subsequently shown to be an inactivated X chromosome. While largely supplanted by more sophisticated genetic tests, it occasionally may be done as a rapid screen.
Chick embryo fibroblasts infected with Rous sarcoma virus in vitro are rendered malignant for such cells produce typical Rous sarcomas when injected into susceptible chicks since the tumors produced predominantly retain the sex chromatin patterns of the donor cells when such cells are injected into a recipient of the opposite sex. However, examination of the sex chromatin of cells at the periphery of the tumor shows presence of recipient cells though the bulk of the tumor is clearly of donor cell origin. Such tumors grow and cause death of the recipient. Injection of RSV induces tumors of the sex of the recipient as also does the injection of transformed cells rendered incapable of multiplication by x-rays. Following their injection into susceptible chicks, the cells transformed in vitro by virus behave in the same manner as tumor cells obtained from tumors induced by virus in vivo and cultivated in the same conditions in vitro.. When such tumors induced by transformed cells are serially ...
A case-control study was conducted in Los Angeles County, CA, of 75 male breast cancer cases aged 20-74 yr at diagnosis to investigate the role of a number of suspected risk factors. The study involved both interviews and laboratory measurements. Factors under study included fertility and marital history, obesity, alcohol and cigarette consumption, use of drugs known or suspected of causing gynecomastia, family history of breast cancer, history of radiation exposure to the upper body, sex chromatin analysis, serum levels of prolactin, testosterone, estrone, estradiol and sex-hormone-binding globulin, as well as urinary levels of estrone, estradiol, and estriol. Two patients versus no controls tested positive for sex chromatin and were excluded from further analyses. The only statistically significant risk factor identified was greater weight of the cases at age 30; a man who weighed 80 or more kg at age 30 had twice the risk of breast cancer of a man weighing less than 60 kg at that age. Serum ...
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Several factors have combined to make the X chromosome of man an object of particular research interest recently and currently (1). The leading factor is, undoubtedly, the cytologic advances which have permitted study of the X chromosome in sex anomalies. The origin and functional significance of the Barr body ("sex chromatin") have been questions for investigation. Discovery of an X-linked blood group has provided a valuable addition to the technical armamentarium for mapping the X chromosome. An hypothesis suggested by Mary Lyon, among others, has stimulated much inquiry into certain functional aspects of the X chromosome.. How much and what ...
This test is done to get cells for chromosome or DNA analysis, most often for genetic testing. The International Olympic Committee adopted the test many years ago to help detect male imposters among female athletes. When the test is used in this way, its called the sex chromatin test. This test may also help establish the sexual identity of newborns. ...
Looking for Drum stick? Find out information about Drum stick. a stick used for playing a drum a variety of sex chromatin found in a very few neutrophilic leukocytes in females with a normal chromosome set. Explanation of Drum stick
Kim, Shinseog et al. "A Mammal-Specific Doublesex Homolog Associates With Male Sex Chromatin And Is Required For Male Meiosis.". PLoS Genet 3.4 (2007): e62. Web. Plos Genet ...
Kim, Shinseog et al. "A Mammal-Specific Doublesex Homolog Associates With Male Sex Chromatin And Is Required For Male Meiosis.". PLoS Genet 3.4 (2007): e62. Web. Plos Genet ...
Intragenomic conflict refers to the evolutionary phenomenon where genes have phenotypic effects that promote their own transmission in detriment of the transmission of other genes that reside in the same genome. The selfish gene theory postulates that natural selection will increase the frequency of those genes whose phenotypic effects cause their transmission to new organisms, and most genes achieve this by cooperating with other genes in the same genome to build an organism capable of reproducing and/or helping kin to reproduce. The assumption of the prevalence of intragenomic cooperation underlies the organism-centered concept of inclusive fitness. However, conflict among genes in the same genome may arise both in events related to reproduction (a gene may "cheat" and increase its own presence in gametes or offspring above the expected according to fair Mendelian segregation and fair gametogenesis) and altruism (genes in the same genome may disagree on how to value other organisms in the ...
Intragenomic conflicts are a fundamental driving force in evolution [1-3]. Sex and later on anisogamy are thought to have evolved as a consequence of conflicts between selfish genetic elements and their host genome [4]. In turn, sex and anisogamy have promoted other conflicts between cytoplasmic and nuclear genes based on their different modes of inheritance [1]. Cytoplasmic genes are only transmitted through females, rendering males a dead end for them. Therefore, selection at the cytoplasmic level favors any manipulation of the sex ratio increasing female production. In response, nuclear genes are selected to re-establish a balanced sex ratio by suppressing or counteracting the action of cytoplasmic elements. These nucleo-cytoplasmic conflicts can have dramatic consequences on sex-allocation and sex-determination systems [1]. One of the most striking examples of such conflicts is cytoplasmic male sterility (CMS) in hermaphroditic plants where mitochondria promote the production of females by ...
X-chromosome (Barr body) - posted in Cell Biology: Hi everybody! I want to know what specific staining procedure is used to demonstrate the X-chromosomes or Barr bodies in cells. Is there a protocol for this? If you have or hapen to know one please send me a copy, thank you very much.
Rhoades initially proposed that neocentromere activity is the key to the observed preferential transmission of Ab10 (Rhoades 1952). Further genetic analyses demonstrated that neocentromere activity is required but not sufficient for meiotic drive (Dawe and Cande 1996; Hiatt and Dawe 2003a). According to Rhoades model for meiotic drive (Figure 1B), a crossover event must first occur in the region between the centromere and knob of a heterozygous Ab10/N10 pair. This creates a heteromorphic dyad where each homologous chromosome contains one knobbed and one nonknobbed sister chromatid. As anaphase begins, the knobs on all chromosomes are activated as neocentromeres and begin their dramatic poleward movement. The speed and efficiency of neocentromere activity enable knobs to reach the spindle poles ahead of the centromeres (Yu et al. 1997), creating an outward orientation that ultimately delivers knobbed chromatids to the upper and lower cells of the linear tetrad. Since only the bottom cell develops ...
Intragenomic conflict occurs when selection acts in opposing directions on elements within a genome. This type of conflict can be a potent source of evolutionary change and innovation, with consequences for the evolution of sex, recombination, and mating systems (reviewed in [1,2]). An important cause of intragenomic conflict is selfish genetic elements (SGEs), which promote their own transmission into the next generation, and as a result can spread through a population even if they are harmful to their carriers (reviewed in [3]). In this study, we focus on a classic SGE, X-chromosome meiotic drive, which occurs when a driving X-chromosome prevents the maturation of Y-bearing sperm during male spermatogenesis [4]. A male that carries an unsuppressed driving X-chromosome will thus transmit it to all of his offspring, rather than the usual 50%, and all of his offspring will be female. This sex-ratio (SR) drive is an especially interesting SGE because a secondary effect of this biased transmission ...
Other articles where Barr body is discussed: sex chromosome: …as a small, dark-staining structure-the Barr body-in the cell nucleus.
What is a Barr body? Barr body is an inactive X-chromosome found in a female somatic cell. The phenomenon of X inactivation or dosage compensation was originally described by Mary Lyon and is also known as lyonization or Lyon law.
As you can see in the picture, lets see the normal chromosome first, I really dont know what is chromatid in that normal chromosome, does it have two chromatids? the upper one and the lower one? Then lets see the left, replicating chromosome. My teacher said the chromosome replicated and then became two chromosomeS, for an example, 46 chromomes in the nuclear, then they replicate, so now become 92? but in the picture, i think it is still one, you need to think it is as a whole though it consists of two? Are there four chromatids there? upper two and lower two? In the example i gave, so though they replicate, still 46? BTW, how the chromosome replicates? Is that like this )( , two put together, so ) is a chromosome, ( is another chromosome Or two cross to each other, like this X, so \ is a chromosome, / is another chromosome ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Is it the case that all the daughters of a females cell will have the same (ie maternal or paternal) X-chromosome inactivated as the parent cell? If not, is it random which chromosome is inactivated ...
The most comprehensive provider of epigenetic kits, antibodies, reagents, and services for DNA methylation, histone modification, and chromatin studies.
Pill with imprint barr 934 is Gray, Capsule-shape and has been identified as Claravis 10 mg. It is supplied by Teva Pharmaceuticals USA.
Has anybody ever used this? I got some bad Eco-Complete that has my Phosphate levels sky high and i am looking into using this to drop it since it...
Ok I know I did something to cause this but I dont know what or what to do about it. Heres what I did. Three days ago I decided to do a major...
Pam & James Barr wieder vorbei 1,000 Pfund Tomaten in einem dankbar, noch anstrengender Tag. Sie haben Barr Farms Besitz, eine Familie Molkerei,
✅ Answered - [One] [Two] [three] [None] are the options of mcq question A woman has a child with Klinefelters syndrome. Number of barr bodies present in the child is realted topics , Genetic basis of Inheritance, Genetic basis of Inheritance topics with 0 Attempts, 0 % Average Score, 2 Topic Tagged and 0 People Bookmarked this question which was asked on Feb 23, 2019 23:23
Chromatin immuno‐precipitation followed by sequencing (ChIP‐Seq) has provided major insights into the molecular mechanisms underlying chromatin dynamics and transcription regulation. In this study, we present Bar‐ChIP, a method derived from ChIP‐Seq that drastically accelerates its current experimental throughput without the need for robotics instrumentation. We compared the quality and precision of the data obtained using Bar‐ChIP with those generated with traditional ChIP‐Seq and assessed the multiplexing potential of the approach. Bar‐ChIP led to several findings that shed light on the interplay between H3K14 acetylation and H3K4 methylation, which we further investigated. Results of these additional studies are also reported here.. Bar‐ChIP relies on direct molecular barcoding of fragmented chromatin prior to immuno‐precipitation, an approach, which, as we demonstrated, does not impact the nucleosomal distribution obtained after chromatin fragmentation. Furthermore, this ...
In 1948, Drs. Barr and Bertram made a ground-breaking discovery when they identified a dense mass of chromatin (material containing the genetic code) present only in female nerve cells. With further research, Dr. Barr demonstrated that this phenomenon occurred in most mammalian cells. This discovery established, for the first time, a relationship between sex chromosome
Health,... WOODCLIFF LAKE N.J. Oct. 5 /- BarrPharma...The Conference Call will also be Webcast live on the Internet.Investo...Log on at least 15 minutes before the call begins to register anddown...About Barr Pharmaceuticals Inc. ...,Barr,Will,Host,Calendar,2007,Third,Quarter,Earnings,Conference,Call,on,November,8,,2007,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Ariel Silvera, an LGBTQ activist and blogger based in Ireland and the UK has written an open letter - entitled An Open Letter to Roseanne Barr, From a Feminist Sister - to Roseanne Barr, in response to transphobic tweets which the actress posted in October. In the open letter - seen…
Roseanne Barr is getting candid about her health. During a new interview, the 62-year-old actress revealed shes slowly losing her eyesight and...
Darlene Barr, MD, FACS is a specialist in Breast SurgeryGeneral Surgery who has an office at 1221 Madison Street Floor 6 in Seattle, WA and can be reached at 206-215-6400.
Visit Healthgrades for information on Dr. Ian Barr, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
iShares MSCI Frontier 100 Fund (FM) Call Transcripts � Find company conference call transcripts for iShares MSCI Frontier 100 Fund and all the companies you research at NASDAQ.com
Dr. John Biglane, a native of Natchez, MS, received a Bachelor of Science degree from Louisiana State University with a major in Biology and a minor in English.
1 Answer - Posted in: dexedrine, dexedrine spansule, dexedrine spansules - Answer: Barr is ok imo for tablets and strangely enough hit or miss with ...
Caring Medical discusses treatments for Barré-Liéou and Cervicocranial syndrome due to vertebral instability, which affects the function of the nerve cell aggregations located in the neck just in front of the vertebrae.
Roseanne barr weight loss video, Creatine supplementation enhances body composition during short-term reisstance training overreaching.
Semi-Conducting Graphite-Gel by Stephen Barr: Computer brain structured like animal brain. (Text quote, book citation included.)
Generic drugs maker Barr Laboratories yesterday revealed that it has been slapped with a patent infringement lawsuit by fellow US firm Sepracor in relation to the inhalable asthma medicine Xopenex (levalbuterol HCl). - News - PharmaTimes
Gentaur molecular products has all kinds of products like :search , QED \ Anti-Epstein Barr Virus \ 18502 for more molecular products just contact us
Connect with Dr. David Barr, Ophthalmology, Seattle, WA. Video chat, send a message, ask a text question, or make a virtual appointment on the doctors Virtual Practice on HealthTap.
National Geographic Explorer and snake wrangler Dr. Brady Barr has been bitten by a lot of creatures over the years. So this book is born from first hand - er,
Randy Barr Randy Barr has generously agreed to donate personalized songs to benefit CCA! Heres a note from Randy: Hi guys After talking with many friends about the donation process weve decided to do digital recordings of your personalized song for a donation of only $10 to the http://caninecancerawareness.org/ I will be going in the […]. [Read more →]. ...
Horse.com is the source for everything equine. From tack to horse supplies and accessories, we have what you need at the lowest prices, guaranteed ...
Index provider MSCI has published plans for handling a Greek exit of the eurozone in both orderly and disorderly scenarios, in a further sign that...
Through our Factor Investing Webinar Series, we provide our insights on recent factor performance reviews and best practices for implementation of single and multi-factor products ...
iShares Edge MSCI USA Size Factor ETF (SIZE) Latest Real-time ETF Quotes - Nasdaq offers real-time quotes & market activity data for US and global markets.
Through our Factor Investing Webinar Series, we provide our insights on recent factor performance reviews and best practices for implementation of single and multi-factor products ...
Epstein Barr - MedHelps Epstein Barr Center for Information, Symptoms, Resources, Treatments and Tools for Epstein Barr. Find Epstein Barr information, treatments for Epstein Barr and Epstein Barr symptoms.
Funeral services for Mrs. John R. BARR were held Monday afternoon, two oclock at the home of her daughter, Mrs. A. L. DENISTON, 1310 South Main street this city. Dr. S. A. STEWART, of LaPorte, Ind., and Rev. Glenn C. McGEE, pastor of the Rochester Presbyterian church, officiated and interment was made in the Barr family lot at the I.O.O.F. cemetery. Mrs. Barr, passed away in her sleep around 6 oclock Saturday morning, October 10th at her home, 306 West 9th Street. Her death was attributed to coronary thrombosis. Friday evening, Mrs. Barr called her doctor to her home but her condition at that time was not regarded as serious. The deceased who spent her entire life in Rochester and vicinity had a legion of friends throughout Fulton and adjacent counties. She was one of the founders of the First Presbyterian church, of Rochester, and prior to her sudden demise, was the oldest living member. Mrs. Barr took an active interest in the work of her church and was also an ardent worker in charitable ...
Time of birth is the only significant difference in these charts. Dalai Lama has Cancer rising, with Cancer Sun and Pluto in first house of self. Candy Barr had Gemini rising with Cancer Sun (just) in first house along with Gemini Mercury. Rising sign is said to be the lens through which an individual is seen by the world -and through which she/he sees the world. There are wide differences between Cancer rising and Gemini rising. Cancer = gentle, caring, nurturing, quiet. Gemini = social butterfly, bubbly, quick-witted, short attention span. So Candy Barr had this one astrological difference from Dalai Lama: the overlay of Gemini to modify her gentle Cancer Sun ...
AbeBooks.com: The Transformed Cell (9780399137495) by Stephen A. Rosenberg; John M. Barr and a great selection of similar New, Used and Collectible Books available now at great prices.
Kos Pharmaceuticals and Barr Pharmaceuticals say that they have signed a co-promotion, licensing and manufacturing deal, which outs the lid on a patent dispute between the two firms over the formers cholesterol-lowering drug, Niaspan (extended release niacin). - News - PharmaTimes
View the basic MSCI stock chart on Yahoo Finance. Change the date range and chart type, and compare MSCI Inc against other companies.
Here is the best resource for homework help with MSCI 531 : Stochastic Processes and Decision Making at University Of Waterloo, Waterloo. Find MSCI531 study
Copyright © 2018 The Horse Media Group LLC. All rights reserved. Reproduction in whole or in part in any form or medium without written permission of The Horse Media Group LLC is prohibited. THE HORSE, THE HORSE logo, THEHORSE.COM and THEHORSE.COM logo are trademarks of The Horse Media Group LLC.. ...
Performance charts for iShares MSCI Finland Capped ETF (EFNL* - Type ETF) including intraday, historical and comparison charts, technical analysis and trend lines.
Dr. Mark Barr welcomed the group and noted there would be a change in the agenda due to a scheduling conflict. As a result, Ms. Cornells presentation was moved up as the first agenda item before the introductions and opening remarks.
Continued from Part 1 The Brazilian real has depreciated over 10% since mid-May, and will likely just get worse The U.S. dollar is likely to strengthen into Q3 2013 for several reasons.…
Despite huge interest in the evolution of warfare, conflicts both between family members and within the warring individual have been relatively neglected. Here, we developed and analysed a model of warfare in the context of sex-biased demography. We found that the ecology of war can drive the evolution of sex-biased dispersal. Moreover, we found that these same patterns of sex-biased dispersal can modulate intrafamily and intragenomic conflicts over warfare, and accordingly parent-of-origin-specific patterns of gene expression-i.e. genomic imprinting-and concomitant mutational and epimutational pathologies in relation to intergroup violence phenotypes.. We have shown that sex-biased dispersal can be driven by sexual asymmetries in the spoils of war. In particular, insofar as warfare enables males extra opportunities to compete with non-kin for breeding positions-thus relaxing kin competition-to an extent that is greater than for females, then males are less strongly favoured to disperse as a ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Hi! when a X chromosome inactivates in a female fetus, creating a Barr body, this happens independently and random. The random selection of which of the X chromosomes( maternal and paternal) to be inactivated in each cell, results in a female mosaic, where the genes in the paternal X chromosome is expressed in some cells, and the maternal one i other cells ...
Their existence has persisted for one important reason: they protect the DNA found at ends of chromosomes from being lost by deterioration which accompanies cell division until the cells reach a "critical level" of genetic information loss. It is at this critical level that cells stop dividing and the process of aging is first seen at a cellular level. Without telomeres protecting DNA from damage and mutation, cancer can also become prevalent. Telomeres are a lot like plastic shoe lace tips that prevent the lace from fraying.. Heterochromatin is a way of describing chromatin: it is tightly coiled, and the opposite is euchromatin. Heterochromatin is usually found towards the "sides" of a cell, in the periphery. Examples of heterochromatin include the Barr body of the female X chromosome, centromeres, and more importantly to this study, telomeres. It is thought that the functionality of heterochromatin is to protect DNA from damage by not allowing it to be exposed to DNA machinery.. When a ...
Template:Talk Page}} ==10 Most Recent Papers==__NOEDITSECTION__ {{10 Most Recent}} ===Meiosis=== ,pubmed limit=10>Meiosis,/pubmed> ==2018== ===Distinct prophase arrest mechanisms in human male meiosis=== {{#pmid:29540502}} Jan SZ1, Jongejan A2, Korver CM1, van Daalen SKM1, van Pelt AMM1, Repping S1, Hamer G3. Author information Abstract To prevent chromosomal aberrations being transmitted to the offspring, strict meiotic checkpoints are in place to remove aberrant spermatocytes. However, in about 1% of males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. Here, we unravel two clearly distinct meiotic arrest mechanisms that occur during prophase of human male meiosis. Type I arrested spermatocytes display severe asynapsis of the homologous chromosomes, disturbed XY-body formation and increased expression of the Y chromosome-encoded gene ZFY and seem to activate a DNA damage pathway leading to induction of p63, possibly causing spermatocyte ...
The arrangement of compact chromatin of G0 lymphocytes was studied in three-dimensional reconstructions of the ensemble of the chromatin and of individual compact chromatin bodies. Rat spleen was seri
Vancouver, British Columbia (Canada) Mrs. Barr is the founder and former executive director for the National Center on Shaken Baby Syndrome. Mrs. Barr...
Former Congressman Bob Barr is one of the best-known third party presidential candidates this election season. Speaking with Farai Chideya, Barr explains the motivation for his candidacy and what he seeks to accomplish with his campaign.
Attorney General William P. Barr said he is not blocking special counsel Robert Mueller from testifying before the House Judiciary Committee, according to a report Thursday.
If you have a single-letter mathop it gets vertically centered unless you put it in a box. For example, I normally define the expectation operator by \newcommand{\expect}{\mathop{\mbox{$\mathbb E$}}\nolimits} Rosemary Bailey On Mon, 3 Nov 2008, Michael Barr wrote: , If you compile the file , \documentclass{article} , \newcommand\II{\mathop{I\mkern-1mu I}} , \newcommand\I{\mathop{I}} , \begin{document} , , $AB\II L$ , , $AB\I L$ , , \end{document} , , you will see (or I do anyway) that the I in the second, but not the first, , formula is going distinctly below the line. What is going on here? If , you take out the \mathop this does not happen. , , Michael Barr , , , _______________________________________________ , TeX FAQ: http://www.tex.ac.uk/faq , Mailing list archives: http://tug.org/pipermail/texhax/ , More links: http://tug.org/begin.html , , Automated subscription management: http://tug.org/mailman/listinfo/texhax , Human mailing list managers: postmaster at tug.org , ...
For sale is a two barrel Pigeon grade Belgium Browning with two 28 barrels. The first set is sktskt. Bores are .727 choke constric for sale by Jim Veta on GunsAmerica - 987962034
Performance charts for iShares MSCI Turkey ETF (ISVZ - Type ETF) including intraday, historical and comparison charts, technical analysis and trend lines.
Get Xtrackers MSCI World Industrials UCITS ETF 1C (XDWI-GB:London Stock Exchange) real-time stock quotes, news and financial information from CNBC.
Morgan Stanley Capital International Inc (MSCI) yesterday said it would lower the weighting of Taiwanese shares in two of its equity indices. The announcement sent the TAIEX plunging to 8,884.09 points, a decline of 0.31 percent.
The subfamily Tillinae Leach is represented by 12 genera in the New World. In this study, eight of these genera are revised. A diagnosis and redescription of the species of Araeodontia Barr, Barrotillus Rifkind, Bogcia ...
Were only supposed to trust the Trump Department of Justice when its Bill Barr covering up the Mueller report. YOU BETCHA, GLENN. ...
Cheers Kenny! Weve talked about that Barr method before too. I still remain very sceptical with off-day creatine intake. There are so many different opinions about this issue, ranging from 2-5g a day no matter what to 5g per on-day. And even some superloading claims of constantly ingesting more than 10g a day, which I dont see reasonable. Yet I havent really found too much research around the off-day vs. every day set-up. At the moment Im still taking 5g a day. If I want more out of it, I load for a couple of weeks with higher doses. I could try if 5g per training day will have the same effects as 5g a day ...
D. N. LeBard, B. G. Levine, P. Mertmann, S. A. Barr, A. Jusufi, S. Sanders, M. L. Klein, and A. Z. Panagiotopoulos; Soft Matter, 8, 2385-97 (2012 ...
AdamBa (Adam Barr) writes Juiced is not a great book. The writing is workmanlike but not particularly entertaining, none of the stories are more than slightly amusing, and its protagonist projects an unappealing mixture of vanity and whining. There is a bit of dirt on players, and a couple of nugge...
Introduction 273. Wolbachia diversity 274. The Wolbachia pandemic in crustaceans 274. Phylogenetic relationships among Wolbachia strains 277. Wolbachia diversity within species and individuals 277. Crustacean Wolbachia genomics 278. Feminization induction 279. Sex differentiation in crustaceans 279. Species-specificity of androgenic hormone and Wolbachia strains 280. Evolutionary consequences of Wolbachia-isopod interactions 284. Diverse sex-ratio distorters in Armadillidium vulgare 284. Theoretical predictions and intragenomic conflicts 284. Distribution in field populations and consequences 286. Wolbachia consequences in host life history traits 287. Conclusion: dynamic evolution of sex determination in Armadillidium vulgare 288. Acknowledgments 289. References 289. ...
Easy or not, we have to accept that in being born we are going to die. Our clocks may be ticking louder and faster now than we expected, and our disease is most likely going to be the cause of our death, but just like life pre-diagnosis, we just dont know. Our doctors werent given a crystal ball and I havent bothered wasting time finding one. -Barbara Barr Barbara Barr has Idiopathic Pulmonary Fibrosis (IPF) - its a disease that an estimated 5,000 to 10,000 Canadians suffer from, says Dr. Shane Shapera, respirologist at TGH. IPF is a disease of scarring in the lungs, which gets worse over time. There is no known cause. The most effective cure currently -- is a lung transplant.. Barr has been a partner in her care at TGH - and takes pride in knowing her disease inside and out. She spends her time helping others in similar situations. This week is IPF World Week and we asked Barr about her experience with IPF.. How were you diagnosed with IPF?. My mother died of lung cancer and my older ...
Browse and shop Barr Cath Kidston Fever-Tree Gardners Hiball Salter Zeus New from Ocado. Find your favourite groceries, household essentials, and our Low Price Promise at ocado.com, the online supermarket.
Barr Jr., W., & Yamashita, T. (1964). Lipoma of the duodenum causing massive melena. The American Journal Of Gastroenterology, 41(4),418-422.. ...
Visit Healthgrades for information on Dr. Nancy Barr, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Curious as to how many here have been diagnosed with CFS due to a positive Epstein Barr issue in blood work in addition to CFS symptoms. Also if anyone has any input if mental illness and CFS can coexi...
According to some sources, the Epstein Barr virus has been implicated as a causal agent of gastric carcinoma (stomach cancer). Several articles on this topic are online. Use browser search words epstein barr virus and gastric carcinoma ...
Chemical make up Alkaloid drugs In the tropane group Alkaloid drugs are defined as naturally occurring amines that are produced by a plant Many have anesthetic or analgesic effects Chemical formula C 17 H 21 NO 4
Since Jim and I are still thinking of maybe collaborating on some art toys in the future we thought wed let you see what may have been (could still be). Hed have been about six inches tall, probably molded in glow in the dark resin or something. like a giant M.U.S.C.L.E thing. And Id like to hear if you would have been interested in buying one of these Dayglo figures, whether youre a fan of the band or not ...
View the basic EWU stock chart on Yahoo Finance. Change the date range, chart type and compare iShares MSCI United Kingdom ETF against other companies.
Get iShares Edge MSCI Europe Size Factor UCITS ETF EUR (Acc) (IEFS-GB:London Stock Exchange) real-time stock quotes, news and financial information from CNBC.
Në një intervistë ekskluzive për ABC News, raportuesi per Shqipërinë, Knut Fleckenstein, deklaron se nuk ka rrugë tjetër përveçse hapjes së dritës jeshile për hapjen e negociatave të anëtarësimit të Shqipërisë në BE. Ai shpreson që shtetet anëtare do ta mbështetin këtë rekomandim dhe nxit qeverinë shqiptare për rezultate të mëtejshme në procesin e Vettingut dhe 5 prioritetet.. -Në kuadrin e tryezës së nivelit të lartë ndërparlamentar me deputetë të vendeve të Ballkanit, ju jeni takuar edhe me delegacionin shqiptar. Të gjitha forcat politike bashkohen se qytetarët e Shqipërisë e meritojnë hapjen e negociatave, por ata ndahen lidhur me forcën politike që mund të hapë negociatat dhe të mbajë barrën e tyre. Çmendoni për këtë?. Knut fleckenstein, raportues për Shqipërinë: "Unë mendoj, se vendimi për hapjen e negociatave duhet të merret sa më shpejt në Bruksel. Duhet të tregojmë, se duam të hapin negociatat e anëtarësimit. Ka një ...
Just wondered if anyone can give some advice regarding testing for Epstein Barr and other Herpes viruses. I have in the past had blood work done,...
Directed by John Whitesell. With Roseanne Barr, John Goodman, Laurie Metcalf, Michael Fishman. Roseanne is wary when Ziggy breezes back into Lanford, romancing Jackie and filling Dans head with notions of opening a bike shop.
Board certified forensic psychiatrist focusing on emotional distress, pain, undue influence, testamentary capacity and employment litigation ...
In order to increase our understanding about the pathogenic mechanism and the strategy of treatment in the subtypes of Guillain Barré syndrome, we will check the temporal changes of cytokines with different biological activities in serum and cerebrospinal fluid (CSF), check the titer of various anti-ganglioside antibodies, perform skin biopsy and correlate these data with the clinical findings such as severity and ...
Metastatic epstein Barr Virus type retropharyngeal adenocarcinoma; need for access for chemo therapy. Can I just icd-9 198.89 or 198.89 with 075 / or
Dr. Fredric M Barr, MD, rated 4.4/5 by patients. 48 reviews, Phone number & practice locations, Plastic Surgeon in West Palm Beach, FL.
To the casual celebrity gossip and 90s TV watcher, Roseanne Barr seeking the nomination of the Green Party to run for president may seem odd, but its all a perfect progression for the comedian-macadamia nut farmer-activist.
The website for the NPR Politics podcast describes it as where NPR political reporters talk to you like they talk to each other -- while assuming that conservatives arent listening. This can lead to unintentionally comedic content, at least for those conservatives who are listening and presumably cringing through the rest of it. NPR Justice Department correspondent Carrie
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Sex chromosome inactivation in male germ cells is a paradigm of epigenetic programming during sexual reproduction. Recent progress has revealed the underlying mechanisms of sex chromosome inactivation in male meiosis. The trigger of chromosome-wide silencing is activation of the DNA damage response (DDR) pathway, which is centered on the mediator of DNA damage checkpoint 1 (MDC1), a binding partner of phosphorylated histone H2AX (γH2AX). This DDR pathway shares features with the somatic DDR pathway recognizing DNA replication stress in the S phase. Additionally, it is likely to be distinct from the DDR pathway that recognizes meiosis-specific double-strand breaks. This review article extensively discusses the underlying mechanism of sex chromosome inactivation. ...
... WOODCLIFF LAKE N.J. Aug. 15 /- BarrPharm...Barr filed its ANDA containing a paragraph IV certification for agene...On August 15 2007 Warner Chilcott announced it had received aParagr...Femcon FE is indicated for the prevention of pregnancy in women whoel...,Barr,Confirms,Filing,an,Application,With,a,Paragraph,IV,Certification,for,Femcon(R),FE,Chewable,Oral,Contraceptive,Product,biological,advanced biology technology,biology laboratory technology,biology device technology,latest biology technology

Changes in Incidence of Sex Chromatin in Subcultured Cells | ScienceChanges in Incidence of Sex Chromatin in Subcultured Cells | Science

Sex chromatin counts of subcultured cells of both female human mammary tumor and female rabbit kidney show a considerable drop ... Changes in Incidence of Sex Chromatin in Subcultured Cells Message Subject. (Your Name) has forwarded a page to you from ... Cultures in which sex chromatin persists also retain the viral insensitivity of their source material. ...
more infohttp://science.sciencemag.org/content/133/3445/43

Barr Body (Sex Chromatin in Somatic Cells) | Medicalalgorithms.comBarr Body (Sex Chromatin in Somatic Cells) | Medicalalgorithms.com

Barr and Bertram described a small body in the nuclei of normal females composed of DNA. This was subsequently shown to be an inactivated X chromosome. While largely supplanted by more sophisticated genetic tests, it occasionally may be done as a rapid screen.
more infohttps://www.medicalalgorithms.com/barr-body-sex-chromatin-in-somatic-cells

Barr body | genetics | BritannicaBarr body | genetics | Britannica

... sex chromosome: …as a small, dark-staining structure-the Barr body-in the cell nucleus. ... The Barr, or sex chromatin, body is an inactive X chromosome. It appears as a dense, dark-staining spot at the periphery of the ... association with sex chromosome. * In sex chromosome. …as a small, dark-staining structure-the Barr body-in the cell nucleus. ... In human genetic disease: Abnormalities of the sex chromosomes. …physically condenses to form a Barr body, a small structure ...
more infohttps://www.britannica.com/science/Barr-body

COMPARATIVE STUDIES IN ROUS SARCOMA WITH VIRUS, TUMOR CELLS AND CHICK EMBRYO CELLS TRANSFORMED IN VITRO BY VIRUS | JEMCOMPARATIVE STUDIES IN ROUS SARCOMA WITH VIRUS, TUMOR CELLS AND CHICK EMBRYO CELLS TRANSFORMED IN VITRO BY VIRUS | JEM

However, examination of the sex chromatin of cells at the periphery of the tumor shows presence of recipient cells though the ... retain the sex chromatin patterns of the donor cells when such cells are injected into a recipient of the opposite sex. ... Injection of RSV induces tumors of the sex of the recipient as also does the injection of transformed cells rendered incapable ... When such tumors induced by transformed cells are serially transferred in recipients of the opposite sex, they gradually ...
more infohttp://jem.rupress.org/content/116/3/329

Intragenomic conflict in populations infected by Parthenogenesis Inducing Wolbachia ends with irreversible loss of sexual...Intragenomic conflict in populations infected by Parthenogenesis Inducing Wolbachia ends with irreversible loss of sexual...

... sex ratio chromosome in the parasitic wasp Trichogramma kaykai condenses the paternal chromosomes into a dense chromatin mass. ... Because of the increasingly female-biased sex ratio in the population during a spreading PI-Wolbachia infection, sex allocation ... These nucleo-cytoplasmic conflicts can have dramatic consequences on sex-allocation and sex-determination systems [1]. One of ... Hoekstra RF: The Evolution of Sexes. Experientia Supplementum (Basel), Vol 55 The Evolution of Sex and Its Consequences 403p ...
more infohttps://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-10-229

Sex Chromatin - Semantic ScholarSex Chromatin - Semantic Scholar

Each X CHROMOSOME, in excess of one, forms sex chromatin (Barr body) in the mammalian nucleus. (from King & Stansfield, A ... a condensed mass of chromatin representing an inactivated X chromosome. ... Sex Chromatin. Known as: chromatin sex, Chromatins, Sex, Barr bodies (More). In the interphase nucleus, a condensed mass of ... Moth sex chromatin probed by comparative genomic hybridization (CGH).. *Ken Sahara, Franttisek Marec, Ulrike Eickhoff, Walther ...
more infohttps://www.semanticscholar.org/topic/Sex-Chromatin/273923

Sex chromatins Synonyms, Sex chromatins Antonyms | Thesaurus.comSex chromatins Synonyms, Sex chromatins Antonyms | Thesaurus.com

Synonyms for sex chromatins at Thesaurus.com with free online thesaurus, antonyms, and definitions. Find descriptive ... sex chromatins. .css-c3577y{font-size:14px;color:#a19f9c;padding-bottom:18px;display:block;}. noun. chromosome determining sex ... sex chromatins. .css-16tby2r{color:#3c7bbe;font-size:13px;font-weight:600;position:relative;bottom:5px;}. see definition of sex ...
more infohttps://www.thesaurus.com/browse/sex%20chromatins

Sex chromatin in mental retardation | Springer for Research & DevelopmentSex chromatin in mental retardation | Springer for Research & Development

The incidence of chromatin positivity among male mental defectives was found to be 4.2 per... ... Barr, M. L. and Carr, D. H. (1960). Sex chromatin, sex chromosomes and sex anomalies.Canad. med. Ass. J. 83, 979.PubMedGoogle ... Observations on the female sex chromatin in human epidermis and on the value of skin biopsy in determining sex.J. Path. Bact. ... Gustavson, K. H., and Akeeson, H. A. (1961). Mental deficiency and aberrant sex chromatin.Ibid. 2, 724.CrossRefGoogle Scholar ...
more infohttps://rd.springer.com/article/10.1007/BF02755407

The Sex Chromatin, Or The Barr Body | Canadians for Health Research | Les Canadiens pour la recherche medicaleThe Sex Chromatin, Or The "Barr Body" | Canadians for Health Research | Les Canadiens pour la recherche medicale

The research during which the sex chromatin was discovered belongs to the category of research known as curiosity-driven ... It was therefore named the sex chromatin because of the sex difference and this discovery was the beginning of the new science ... The research during which the sex chromatin was discovered belongs to the category of research known as curiosity-driven ... The research during which the sex chromatin was discovered belongs to the category of research known as curiosity-driven ...
more infohttps://chrcrm.org/en/salute-excellence/sex-chromatin-or-barr-body

Moth sex chromatin probed by comparative genomic hybridization (CGH) : HUSCAPMoth sex chromatin probed by comparative genomic hybridization (CGH) : HUSCAP

Moth sex chromatin probed by comparative genomic hybridization (CGH). フルテキスト Genome46(2).pdf. 1.16 MB. PDF. 見る/開く. ... Moth sex chromatin probed by comparative genomic hybridization (CGH). 著者: Sahara, Ken 著作を一覧する. Marec, František 著作を一覧する. ... Our results show that CGH can be applied to obtain a first estimate of the sequence composition of sex chromosomes in species ... of differently labeled genomic DNA from females and males highlighted the W chromosomes in mitotic plates and the W chromatin ...
more infohttps://eprints.lib.hokudai.ac.jp/dspace/handle/2115/891

Anatomy Topic 01 Barr body & Sex chromatin | DREAMZ MEDICAL EDUTECHAnatomy Topic 01 Barr body & Sex chromatin | DREAMZ MEDICAL EDUTECH

120 hours revision of 500 Video Lectures Crash Course on Anatomy, Physiology, Biochemistry based on University Previous Exam Question Papers..
more infohttps://dreamz-medical-edutech.teachable.com/courses/mbbs-1st-year/lectures/10562472

Sex chromosomes, recombination, and chromatin conformation.  - PubMed - NCBISex chromosomes, recombination, and chromatin conformation. - PubMed - NCBI

Sex chromosomes, recombination, and chromatin conformation.. McKee BD1, Handel MA.. Author information. 1. Department of ... We propose that sex chromosome condensation is a meiotic adaptation to prevent the initiation of potentially damaging ... We review what is known about the transcriptional inactivation and condensation of heteromorphic sex chromosomes in contrast to ... We relate these cytological and transcriptional features to the recombination status of the sex chromosomes. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8432196?dopt=Abstract

Evaluation of sex chromatin of calfs neutrophils as a diagnostic tool for bovine freemartinism at their early lifeEvaluation of sex chromatin of calf's neutrophils as a diagnostic tool for bovine freemartinism at their early life

Evaluation of sex chromatin of calfs neutrophils as a diagnostic tool for bovine freemartinism at their early life ... Evaluation of sex chromatin of calfs neutrophils as a diagnostic tool for bovine freemartinism at their early life ...
more infohttps://www.ajas.info/journal/view.php?number=18666

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.  - PubMed - NCBIH2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. - PubMed - NCBI

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.. Fernandez-Capetillo O1, ... Moreover, other sex body proteins, including macroH2A1.2 and XMR, do not preferentially localize with the sex chromosomes in ... The molecular basis and biological function of both sex body formation and meiotic sex chromosome inactivation (MSCI) are ... Here we show that the X and Y chromosomes of histone H2AX-deficient spermatocytes fail to condense to form a sex body, do not ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/12689589?dopt=Abstract

The impact of testicular and accessory sex gland function ion sperm chromatin integrity as assessed by the sperm chromatin...The impact of testicular and accessory sex gland function ion sperm chromatin integrity as assessed by the sperm chromatin...

The impact of testicular and accessory sex gland function ion sperm chromatin integrity as assessed by the sperm chromatin ... accessory sex glands, SCSA, sperm chromatin, zine, testosterone. in Human Reproduction. volume. 17. issue. 12. pages. 3162 - ... The impact of testicular and accessory sex gland function ion sperm chromatin integrity as assessed by the sperm chromatin ... BACKGROUND: The sperm chromatin structure assay (SCSA) provides an objective assessment of sperm chromatin integrity, which is ...
more infohttps://lup.lub.lu.se/search/publication/892161

Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene...Impact of 3-dimensional genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene...

Several thousand sex-differential distal enhancers have been identified; however, their links to sex-biased genes and the ... p,Background: Sex differences in the transcriptome and epigenome are widespread in mouse liver and are associated with sex-bias ... Sex-differential chromatin interactions involving sex-biased gene promoters, enhancers, and lncRNAs were associated with sex- ... Sex-differential chromatin interactions involving sex-biased gene promoters, enhancers, and lncRNAs were associated with sex- ...
more infohttps://www.researchsquare.com/article/13958c00-199a-425d-aaa4-041eb1445c88/v1

Sex chromosome control of chromatin in the gametes - Bluma LeschSex chromosome control of chromatin in the gametes - Bluma Lesch

The sex chromosomes of mammalian germ cells must match those of the surrounding soma in order for the germ cells to ... Sex chromosome control of chromatin in the gametes Lesch, Bluma Jessica Whitehead Institute for Biomedical Research, Cambridge ... Sex chromosome control of chromatin in the gametes. Lesch, Bluma Jessica / Whitehead Institute for Biomedical Research. $59,966 ... Sex chromosome control of chromatin in the gametes. Lesch, Bluma Jessica / Whitehead Institute for Biomedical Research. ...
more infohttp://grantome.com/grant/NIH/F32-HD075591-01A1

KAKEN - Research Projects | Analysis of chromatin structure and gene function of chicken sex chromosomes (KAKENHI-PROJECT...KAKEN - Research Projects | Analysis of chromatin structure and gene function of chicken sex chromosomes (KAKENHI-PROJECT...

Analysis of chromatin structure and gene function of chicken sex chromosomes. Research Project ... Publications] Shigeki Mizuno: Sex-specific DNA sequences in Galliformes and their application to the study of sex ... Chicken / Sex Chromosome / W Chromosome / Z Chromosome / Heterochromatin / Sex Chromosome-speicific Library / Genomic Library ... Constitution of chicken sex chromosomes is ZW for female and ZZ for male. About 2/3 of the W chromosome and a terminal region ...
more infohttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05454068/

Buccal smear: MedlinePlus Medical EncyclopediaBuccal smear: MedlinePlus Medical Encyclopedia

Barr body analysis buccal smear for staining sex chromatin mass - diagnostic. In: Chernecky CC, Berger BJ, eds. Laboratory ... When the test is used in this way, its called the sex chromatin test. ...
more infohttps://medlineplus.gov/ency/article/003414.htm

Ancestral chromatin configuration constrains chromatin evolution on differentiating sex chromosomes in Drosophila | Haldanes...Ancestral chromatin configuration constrains chromatin evolution on differentiating sex chromosomes in Drosophila | Haldane's...

... dx.doi.org/10.1101/019786 Sex chromosomes evolve distinctive types of chromatin from a pair of ancestral autosomes that are ... In Drosophila, the dosage-compensated X becomes enriched for hyperactive chromatin in males (mediated by H4K16ac), while the Y ... Ancestral chromatin configuration constrains chromatin evolution on differentiating sex chromosomes in Drosophila Qi Zhou, ... Ancestral chromatin configuration constrains chromatin evolution on differentiating sex chromosomes in Drosophila. Posted on ...
more infohttps://haldanessieve.org/2015/05/26/ancestral-chromatin-configuration-constrains-chromatin-evolution-on-differentiating-sex-chromosomes-in-drosophila/

Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible...Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible...

... repeat-induced chromatin structure changes could indeed be the initial event in sex chromosome emergence. ... Our study provides for the first time evidence for the hypothesis that, at least in organisms with a ZW type of sex chromosomes ... Transcription and chromatin status of female-specific repeats are stage-specific: for those repeats that are transcribed, ... mansoni sex chromosomes. We show that 70 to 90% of S. mansoni W and Z are pseudoautosomal. No female-specific gene could be ...
more infohttps://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-2-r14

H2AFY - Core histone macro-H2A.1 - Homo sapiens (Human) - H2AFY gene & proteinH2AFY - Core histone macro-H2A.1 - Homo sapiens (Human) - H2AFY gene & protein

... which induces a hypoacetylated state of chromatin (PubMed:16428466, PubMed:16107708). ... Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a ... sex chromatin Source: BHF-UCL ,p>Traceable Author Statement,/p> ,p>Used for information from review articles where the original ... chromatin DNA binding Source: UniProtKB ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function, ...
more infohttps://www.uniprot.org/uniprot/O75367

Corpus ciliare | definition of corpus ciliare by Medical dictionaryCorpus ciliare | definition of corpus ciliare by Medical dictionary

Barr body sex chromatin.. basal body a modified centriole that occurs at the base of a flagellum or cilium. ... Howells bs (Howell-Jolly bs) smooth, round remnants of nuclear chromatin seen in erythrocytes in megaloblastic and hemolytic ...
more infohttps://medical-dictionary.thefreedictionary.com/corpus+ciliare

Body Dismorphic Diorder | definition of Body Dismorphic Diorder by Medical dictionaryBody Dismorphic Diorder | definition of Body Dismorphic Diorder by Medical dictionary

Barr body sex chromatin.. basal body a modified centriole that occurs at the base of a flagellum or cilium. ... Howells bs (Howell-Jolly bs) smooth, round remnants of nuclear chromatin seen in erythrocytes in megaloblastic and hemolytic ...
more infohttps://medical-dictionary.thefreedictionary.com/Body+Dismorphic+Diorder
  • article{7cc3097b-22b4-448a-9bce-4c18189ec61f, abstract = {BACKGROUND: The sperm chromatin structure assay (SCSA) provides an objective assessment of sperm chromatin integrity, which is essential for normal sperm function. (lu.se)
  • Moth sex chromatin probed by comparative genomic hybridization (CGH). (semanticscholar.org)
  • Results: To address these issues, we first characterized 1,847 mouse liver genomic regions showing significant sex differential occupancy by cohesin and CTCF, two key 3D nuclear organizing factors. (researchsquare.com)
  • A phosphorylated form of H2AX, a histone H2A variant implicated in DNA repair, accumulates in the sex body in a manner independent of meiotic recombination-associated double-strand breaks. (nih.gov)
  • Conclusions: These findings elucidate how 3-dimensional genome organization contributes to sex differences in gene expression in a non-reproductive tissue through both direct and indirect effects of cohesin and CTCF looping on distal enhancer interactions with sex-differentially expressed genes. (researchsquare.com)
  • Publications] Shigeki Mizuno: 'Sex-specific DNA sequences in Galliformes and their application to the study of sex differentiation' In : Manipulation of the Avian Genome (R.J.Etches and A.M.V.Gibbins, eds. (nii.ac.jp)
  • Sex-differential chromatin interactions involving sex-biased gene promoters, enhancers, and lncRNAs were associated with sex-biased binding of cohesin and/or CTCF. (researchsquare.com)
  • By setting up different chromatin states at important promoters in XX and XY germ cells, the X/Y-encoded demethylases may predispose these cells to respond differently to cues from XX or XY somatic tissue, thus enabling appropriate male or female gamete differentiation. (grantome.com)
  • CONCLUSIONS: Sex steroid production, spermatogenic function, abstinence time and seminal vesicle function appear to impact on sperm chromatin integrity and thereby on sperm fertilizing capacity. (lu.se)
  • These two pairs of X-Y histone demethylase homologs target H3K4me3 and H3K27me3, two chromatin marks that play a central role in regulating the balance between pluripotency and differentiation. (grantome.com)
  • In this model, the emergence of a locus with female fertility and male sterility and another locus with male fertility and female sterility led to the establishment of a small sex-determining region on ordinary autosomes in hermaphrodite ancestors. (biomedcentral.com)
  • BACKGROUND: The sperm chromatin structure assay (SCSA) provides an objective assessment of sperm chromatin integrity, which is essential for normal sperm function. (lu.se)
  • Levels of reproductive hormones, the length of the CAG repeat of the androgen receptor gene, sperm concentration, abstinence period and biochemical parameters of epididymal and accessory sex gland secretions were correlated to the SCSA parameters, DNA fragmentation index (DFI) and highly. (lu.se)
  • These sex-differential binding sites were largely distal to sex-biased genes, but rarely generated sex-differential TAD (topologically associating domain) or intra-TAD loop anchors. (researchsquare.com)
  • None of the female patients with mental retardation was chromatin negative. (springer.com)
  • Observations on the female sex chromatin in human epidermis and on the value of skin biopsy in determining sex. (springer.com)
  • Sex chromatin counts of subcultured cells of both female human mammary tumor and female rabbit kidney show a considerable drop from an initial high level. (sciencemag.org)
  • Publications] Noriyuki Suka: 'W-heterochromatin of chicken;its unusual DNA components,late replication,and chromatin structure' Genetica. (nii.ac.jp)
  • its unusual DNA components, late replication, and chromatin structure' Genetica. (nii.ac.jp)
  • SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes. (semanticscholar.org)