Serum Globulins
Hepatitis A
Immune Sera
Globulins
Sex Hormone-Binding Globulin
Hospital Rapid Response Team
Arkansas
Epidemiology
Centers for Disease Control and Prevention (U.S.)
Georgia
Immunization Schedule
Transport of solutes through cartilage: permeability to large molecules. (1/352)
A review of the transport of solutes through articular cartilage is given, with special reference to the effect of variations in matrix composition. Some physiological implications of our findings are discussed. Also, results of an experimental study of the permeability of articular cartilage to large globular proteins are presented. Because of the very low partition coefficients of large solutes between cartilage and an external solution new experimental techniques had to be devised, particularly for the study of diffusion. The partition coefficients of solutes were found to decrease very steeply with increase in size, up to serum albumin. There was, however, no further decrease for IGG. The diffusion coefficient of serum albumin in cartilage was relatively high (one quarter of the value in aqueous solution). These two facts taken together suggest that there may be a very small fraction of relatively large pores in cartilage through which the transport of large molecules is taking place. The permeability of cartilage to large molecules is extremely sensitive to variations in the glycosaminoglycan content: for a threefold increase in the latter there is a hundredfold decrease in the partition coefficient. For cartilage of fixed charge density around 0-19 m-equiv/g, there is no penetration at all of globular proteins of size equal to or larger than serum albumin. (+info)Decreased anion gap associated with monoclonal and pseudomonoclonal gammopathy. (2/352)
Nine patients with monoclonal and one with pseudomonoclonal gammopathy were found to have a decreased anion gap. Eight of the patients had multiple myeloma, one has plasma cell leukemia and one had chronic active hepatitis. In all of the the decreased anion gap was associated with an increased concentration of IgG greater than 5 g/dl. (+info)Fibrinolytic properties of activated FXII. (3/352)
Activated factor XII (FXIIa), the initiator of the contact activation system, has been shown to activate plasminogen in a purified system. However, the quantitative role of FXIIa as a plasminogen activator in contact activation-dependent fibrinolysis in plasma is still unclear. In this study, the plasminogen activator (PA) activity of FXIIa was examined both in a purified system and in a dextran sulfate euglobulin fraction of plasma by measuring fibrinolysis in a fibrin microtiter plate assay. FXIIa was found to have low PA activity in a purified system. Dextran sulfate potentiated the PA activity of FXIIa about sixfold, but had no effect on the PA activity of smaller fragments of FXIIa, missing the binding domain for negatively charged surfaces. The addition of small amounts of factor XII (FXII) to FXII-deficient plasma induced a large increase in contact activation-dependent PA activity, as measured in a dextran sulfate euglobulin fraction, which may be ascribed to FXII-dependent activation of plasminogen activators like prekallikrein. When more FXII was added, PA activity continued to increase but to a lesser extent. In normal plasma, the addition of FXII also resulted in an increase of contact activation-dependent PA activity. These findings suggested a significant contribution of FXIIa as a direct plasminogen activator. Indeed, at least 20% of contact activation-dependent PA activity could be extracted from a dextran sulfate euglobulin fraction prepared from normal plasma by immunodepletion of FXIIa and therefore be ascribed to direct PA activity of FXIIa. PA activity of endogenous FXIIa immunoadsorped from plasma could only be detected in the presence of dextran sulfate. From these results it is concluded that FXIIa can contribute significantly to fibrinolysis as a plasminogen activator in the presence of a potentiating surface. (+info)alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. (4/352)
Mice deficient in either or both mouse alpha2-macroglobulin (MAM) and murinoglobulin-1 (MUG1) were generated and proved phenotypically normal under standard conditions. Acute pancreatitis was induced with a diet deficient in choline and methionine, supplemented with ethionine. The mortality was less than 25% in wild-type mice, as opposed to at least 56% in knockout mice, and was highest (70%) in MAM-/- mice, with earliest onset at 2 days. Plasma amylase and lipase levels were increased, but pancreatic tissue appeared histologically variable in individual mice. The clinical symptoms were most severe in MAM-/- mice and, surprisingly, were not aggravated in the double knockout mice, suggesting that the lack of proteinase inhibition capacity was not the major problem. Therefore, we analyzed the expression of 21 different cytokines and polypeptide factors in the pancreas of all experimental groups of mice. Interleukin-1-receptor antagonist mRNA was consistently induced by the diet in the pancreas of MAM-/- mice, and transforming growth factor-beta, tumor necrosis factor-alpha, tumor necrosis factor-beta, beta-lymphotoxin, and interferon-gamma mRNA levels were also increased. The data demonstrate the important role of alpha2-macroglobulin (A2M) in acute pancreatitis as both a proteinase inhibitor and a cytokine carrier. Mice deficient in MAM and/or MUG thus offer new experimental models for defining in vivo the role of the macroglobulins in pancreatitis and in other normal and pathological processes. (+info)Association of plasma IgM with body size, histopathologic changes, and plasma chemistries in adult Pacific herring Clupea pallasi. (5/352)
Pacific herring Clupea pallasi immunoglobulin is an IgM-like molecule comprised of heavy and light chains with molecular weights of 79 and 25 to 27 kD, respectively. Purified immunoglobulin was used to generate highly specific polyclonal antibodies for development of a sandwich ELISA. The ELISA was used to quantify total plasma IgM in 602 Pacific herring captured in Prince William Sound and Sitka Sound, Alaska, USA. Plasma IgM concentrations ranged from 0.13 to 5.32 mg ml-1. Using multiple stepwise regression analysis, plasma IgM was highly correlated (p < or = 0.01) with body length, Ichthyophonus hoferi infection, plasma albumin, plasma cholesterol, liver macrophage aggregates, and focal skin reddening. I. hoferi was the only organism significantly associated with plasma IgM. Gender, site, and season (spring vs fall) did not contribute to significant differences in plasma IgM. This study contributes to the understanding of the interaction of body size, plasma chemistries, and pathological changes upon circulating immunoglobulins in fish. (+info)Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein. (6/352)
We previously demonstrated that bovine serum conglutinin has markedly greater ability to inhibit influenza A virus (IAV) infectivity than other collectins. We now show that recombinant conglutinin and a chimeric protein containing the NH(2) terminus and collagen domain of rat pulmonary surfactant protein D (rSP-D) fused to the neck region and carbohydrate recognition domain (CRD) of conglutinin (termed SP-D/Cong(neck+CRD)) have markedly greater ability to inhibit infectivity of IAV than wild-type recombinant rSP-D, confirming that the potent IAV-neutralizing activity of conglutinin resides in its neck region and CRD. Furthermore, by virtue of incorporation of the NH(2) terminus and collagen domain of SP-D, SP-D/Cong(neck+CRD) caused substantially greater aggregation of IAV particles and enhancement of neutrophil binding of, and H(2)O(2) responses to, IAV than recombinant conglutinin or recombinant rSP-D. Hence, SP-D/Cong(neck+CRD) combined favorable antiviral and opsonic properties of conglutinin and SP-D. This study demonstrates an association of specific structural domains of SP-D and conglutinin with specific functional properties and illustrates that antimicrobial activities of wild-type collectins can be enhanced through recombinant strategies. (+info)Identical or overlapping sequences in the primary structure of human alpha(2)-macroglobulin are responsible for the binding of nerve growth factor-beta, platelet-derived growth factor-BB, and transforming growth factor-beta. (7/352)
alpha(2)-Macroglobulin (alpha(2)M) functions as a proteinase inhibitor and as a carrier of diverse growth factors. In this study, we localized binding sites for platelet-derived growth factor-BB (PDGF-BB) and nerve growth factor-beta (NGF-beta) to a linear sequence in the 180-kDa human alpha(2)M subunit which includes amino acids 591-774. A glutathione S-transferase fusion protein containing amino acids 591-774 (FP3) bound PDGF-BB and NGF-beta in ligand blotting assays whereas five other fusion proteins, which collectively include amino acids 99-590 and 775-1451 did not. The K(D) values for PDGF-BB and NGF-beta binding to immobilized FP3 were 300 +/- 40 and 180 +/- 30 nM, respectively; these values were comparable with those determined using methylamine-modified alpha(2)M, suggesting that higher-order alpha(2)M structure is not necessary for PDGF-BB and NGF-beta binding. PDGF-BB and NGF-beta blocked the binding of transforming growth factor-beta1 (TGF-beta1) to FP3. Furthermore, murinoglobulin, which is the only known member of the alpha-macroglobulin family that does not bind TGF-beta, also failed to bind PDGF-BB and NGF-beta. These results support the hypothesis that either a single linear sequence in human alpha(2)M or overlapping sequences are responsible for the binding of TGF-beta, PDGF-BB, and NGF-beta, even though there is minimal sequence identity between these three growth factors. FP3 blocked the binding of PDGF-BB to a purified chimeric protein, in which the extracellular domain of the PDGF beta receptor was fused to the IgG(1) Fc domain, and to PDGF receptors on NIH 3T3 cells. Thus, FP3 may inhibit the activity of PDGF-BB. (+info)Photoaffinity glycoprobes-a new tool for the identification of lectins. (8/352)
One of the proposed functions for the carbohydrate structures on glycoconjugates is the transfer of information through interaction with specific lectin receptors. However, the number of elucidated functional lectin-carbohydrate interactions is still relatively small, largely due to the lack of adequate methods to identify lectin activity in complex biological samples. Aiming to solve this problem, we have developed a method based on the novel group of compounds we named glycoprobes. The glycoprobe consists of three vital parts: (1) glycan, (2) digoxin tag, and (3) photoreactive crosslinker. When incubated in dark, oligosaccharide part of the glycoprobe forms a complex with lectin. After illumination, covalent link between the probe and the lectin is formed resulting in a digoxin-tagged lectin. Using antibodies against digoxin, this complex can easily be identified immuno/cytochemically, or by Western blots. To demonstrate the applicability of glycoprobes we have used Man(9)-glycoprobe (containing Man(9)oligosaccharide) and YEE(ahGalNAc)(3)-glycoprobe (containing a synthetic neoglycopeptide with three terminal N-acetyl-galactosamine residues; Lee and Lee, Glycoconjugate J., 1987,4, 317) to identify lectins in bovine serum and rat liver membranes. The simplicity of the method enables its application in routine monitoring of changes in lectin activity during various developmental or pathological processes. An example of GalNAc-binding analysis in human serum is shown. (+info)Serum globulins are a group of proteins present in the liquid portion of blood, known as serum. They are produced by the immune system in response to foreign substances such as bacteria, viruses, and allergens. Serum globulins include several types of immunoglobulins (antibodies), complement components, and other proteins involved in the immune response.
The serum globulin level is often measured as part of a complete blood count (CBC) or a protein electrophoresis test. An elevated serum globulin level may indicate an ongoing infection, inflammation, or an autoimmune disorder. Conversely, a decreased level may suggest a liver or kidney disease, or a malnutrition condition. It is important to note that the interpretation of serum globulin levels should be done in conjunction with other laboratory and clinical findings.
Hepatitis A is a viral infection that specifically targets the liver, causing inflammation and impaired function. This disease is caused by the hepatitis A virus (HAV), which spreads primarily through the fecal-oral route, often due to poor sanitation and hygiene. Individuals can become infected by consuming food or water contaminated with HAV or by coming into direct contact with an infected person's stool.
The symptoms of hepatitis A may include fatigue, loss of appetite, nausea, vomiting, abdominal pain, dark urine, clay-colored bowel movements, joint pain, and jaundice (yellowing of the skin and eyes). However, in some cases, particularly in children under six years old, the infection may be asymptomatic.
While hepatitis A can be unpleasant and cause serious complications, it is rarely fatal and most people recover completely within a few months. Preventive measures include vaccination, practicing good hygiene, and avoiding potentially contaminated food and water.
'Immune sera' refers to the serum fraction of blood that contains antibodies produced in response to an antigenic stimulus, such as a vaccine or an infection. These antibodies are proteins known as immunoglobulins, which are secreted by B cells (a type of white blood cell) and can recognize and bind to specific antigens. Immune sera can be collected from an immunized individual and used as a source of passive immunity to protect against infection or disease. It is often used in research and diagnostic settings to identify or measure the presence of specific antigens or antibodies.
Globulins are a type of protein found in blood plasma, which is the clear, yellowish fluid that circulates throughout the body inside blood vessels. They are one of the three main types of proteins in blood plasma, along with albumin and fibrinogen. Globulins play important roles in the immune system, helping to defend the body against infection and disease.
Globulins can be further divided into several subcategories based on their size, electrical charge, and other properties. Some of the major types of globulins include:
* Alpha-1 globulins
* Alpha-2 globulins
* Beta globulins
* Gamma globulins
Gamma globulins are also known as immunoglobulins or antibodies, which are proteins produced by the immune system to help fight off infections and diseases. There are five main classes of immunoglobulins: IgA, IgD, IgE, IgG, and IgM. Each class of immunoglobulin has a different function in the body's defense mechanisms.
Abnormal levels of globulins can be indicative of various medical conditions, such as liver disease, kidney disease, or autoimmune disorders. Therefore, measuring the levels of different types of globulins in the blood is often used as a diagnostic tool to help identify and monitor these conditions.
Sex Hormone-Binding Globulin (SHBG) is a protein produced mainly in the liver that plays a crucial role in regulating the active forms of the sex hormones, testosterone and estradiol, in the body. SHBG binds to these hormones in the bloodstream, creating a reservoir of bound hormones. Only the unbound (or "free") fraction of testosterone and estradiol is considered biologically active and can easily enter cells to exert its effects.
By binding to sex hormones, SHBG helps control their availability and transport in the body. Factors such as age, sex, infection with certain viruses (like hepatitis or HIV), liver disease, obesity, and various medications can influence SHBG levels and, consequently, impact the amount of free testosterone and estradiol in circulation.
SHBG is an essential factor in maintaining hormonal balance and has implications for several physiological processes, including sexual development, reproduction, bone health, muscle mass, and overall well-being. Abnormal SHBG levels can contribute to various medical conditions, such as hypogonadism (low testosterone levels), polycystic ovary syndrome (PCOS), and certain types of cancer.
A Hospital Rapid Response Team (RRT) is a multidisciplinary group of healthcare professionals who quickly respond to patients in acute care settings, outside of the intensive care unit (ICU), who are experiencing or at risk of deterioration in their clinical status. The team typically includes critical care nurses, respiratory therapists, and physicians, with additional expertise available as needed. They provide immediate assessment, intervention, and stabilization to prevent further decline and potential transfer to the ICU. RRTs aim to improve patient outcomes, reduce cardiac arrests, and enhance communication and collaboration among healthcare providers.
I apologize for any confusion, but "Arkansas" is a proper noun and refers to a state in the United States. It does not have a medical definition. Arkansas is located in the southern region of the U.S. and is known for its diverse geography, which includes mountains, forests, and lowlands. The capital and largest city of Arkansas is Little Rock.
If you have any questions related to health or medicine, I would be happy to try to help answer them.
Epidemiology is the study of how often and why diseases occur in different groups of people and places. It is a key discipline in public health and informs policy decisions and evidence-based practices by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists use various study designs, including observational studies, experiments, and surveys, to collect and analyze data on the distribution and determinants of diseases in populations. They seek to understand the causes of health outcomes and develop strategies to control or prevent adverse health events. The ultimate goal of epidemiology is to improve population health and eliminate health disparities.
I'm sorry for any confusion, but "Georgia" is not a medical term or condition. It is a place name, referring to either a state in the United States or a country in Eastern Europe. If you have any questions about medical conditions or terminology, I would be happy to help with those!
An immunization schedule is a series of planned dates when a person, usually a child, should receive specific vaccines in order to be fully protected against certain preventable diseases. The schedule is developed based on scientific research and recommendations from health organizations such as the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC).
The immunization schedule outlines which vaccines are recommended, the number of doses required, the age at which each dose should be given, and the minimum amount of time that must pass between doses. The schedule may vary depending on factors such as the individual's age, health status, and travel plans.
Immunization schedules are important for ensuring that individuals receive timely protection against vaccine-preventable diseases, and for maintaining high levels of immunity in populations, which helps to prevent the spread of disease. It is important to follow the recommended immunization schedule as closely as possible to ensure optimal protection.
Advisory committees, in the context of medicine and healthcare, are groups of experts that provide guidance and recommendations to organizations or governmental bodies on medical and health-related matters. These committees typically consist of physicians, researchers, scientists, and other healthcare professionals who have expertise in a specific area.
Their roles can include:
1. Providing expert advice on clinical guidelines, treatment protocols, and diagnostic criteria.
2. Evaluating the safety and efficacy of medical products, such as drugs and devices.
3. Making recommendations on public health policies and regulations.
4. Assessing the impact of new research findings on clinical practice.
5. Providing education and training to healthcare professionals.
Advisory committees can be found at various levels, including within hospitals and medical institutions, as well as at the state and federal level. Their recommendations are intended to help inform decision-making and improve the quality of care delivered to patients. However, it's important to note that these committees do not have legislative or regulatory authority, and their recommendations are non-binding.
Cirrhosis
Walter Ruggles Campbell
Human serum albumin
Autoimmune pancreatitis
Edestin
Complement system
Humoral immunity
Globulin
Serum total protein
Alpha-1 antitrypsin deficiency
Serpin
Gamma globulin
Felix Haurowitz
Gel electrophoresis of proteins
Benign prostatic hyperplasia
Angiotensin
Anordrin
Liver disease
Management of hair loss
Jehovah's Witnesses
Cohn process
Fibrolamellar hepatocellular carcinoma
Iodine deficiency in China
Estramustine phosphate
Lymphangiectasia
Passive immunity
Medroxyprogesterone acetate
Aflatoxin B1
List of dog diseases
Hydrocortisone
Serum globulin electrophoresis: MedlinePlus Medical Encyclopedia
Rabbit antithymocyte globulin-induced serum sickness disease and human kidney graft survival
Changes in serum alpha2 globulins in reticuloses | Journal of Clinical Pathology
SERUM GLOBULIN
Serum Globulin
Thyroxine Binding Globulin, Serum - In-Common Laboratories
Anti-Human Globulin Sera for Testing Antibodies | Grifols
What is immune serum globulin used for? - Studybuff.com
Thyroxine Binding Globulin (TBG) Serum Test Price in kota
Evaluation of immune serum globulin for control of infectious hepatitis
Milk-Alkali Syndrome Workup: Approach Considerations, Serum Parathyroid Hormone, Serum Albumin and Globulin
Normal Guinea Pig Serum | JIR
Immunoperoxidase demonstration of human serum globulin binding to islet tissue - Fingerprint - Experts@Minnesota
Thyroxine-Binding Globulin Deficiency: Overview, Molecular Biology of TBG, Etiology
Human serum albumin - Wikipedia
TBG blood test: MedlinePlus Medical Encyclopedia
The Serologic Specificity of Radiation Altered Human Serum γ-Globulin | The Journal of Immunology | American Association of...
Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: A...
Serum globulin levels in predicting the extent of hepatic fibrosis in patients with recurrent post-transplant hepatitis C...
A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary...
Equine Anti-Thymocyte Globulin (ATGAM) administration in patient with previous rabbit Anti-Thymocyte Globulin (Thymoglobulin)...
Sex Hormone Binding Globulin (SHBG), Human | LeeBio.com
Leishmania infantum and Human Visceral Leishmaniasis, Argentina - Volume 18, Number 2-February 2012 - Emerging Infectious...
Vaccination Sticking Points
The LAL Assay for Pyrogen Testing Of Parenteral Products Evolution Challenges
Testosterone: Too High | GreenMedInfo | Disease | Natural Medicine
Immunoglobulin Subunits | Harvard Catalyst Profiles | Harvard Catalyst
Albumin4
- Serum calcium levels must be interpreted with regard to serum albumin levels, although use of the formula for correction of calcium for hypoalbuminemia is validated only in cirrhosis of the liver. (medscape.com)
- 95%) of THs are thyroxine-binding globulin (TBG), transthyretin (TTR, or prealbumin), and albumin. (medscape.com)
- In the current study, we have examined the association of body shape phenotypes based on allometric indices with serum levels of oestradiol and testosterone and their binding proteins (SHBG and albumin) and have explored heterogeneity by BMI, separately in men and women from the UK Biobank cohort, defining in men subgroups according to age and in women subgroups according to menopausal status and use of hormone replacement therapy (HRT). (nature.com)
- Dosage for female athletes serum to sex hormone-binding globulin (SHBG) and albumin. (sideload.com)
SHBG8
- To determine whether hyperinsulinemia can directly reduce serum sex hormone-binding globulin (SHBG) levels in obese women with the polycystic ovary syndrome, six obese women with this disorder were studied. (qxmd.com)
- Serum SHBG levels, however, did not change (18.8 +/- 2.8 nmol/L on day -56 vs. 17.8 +/- 2.6 nmol/L on day 0). (qxmd.com)
- In contrast, serum SHBG levels rose by 32% from 17.8 +/- 2.6 nmol/L on day 0 to 23.5 +/- 2.0 nmol/L on day 10 (P less than 0.003). (qxmd.com)
- Due primarily to the rise in serum SHBG levels, serum non-SHBG-bound testosterone levels fell by 43% from 19 +/- 5 pmol/L on day 0 to 11 +/- 4 pmol/L on day 10 (P = 0.05). (qxmd.com)
- These observations suggest that hyperinsulinemia directly reduces serum SHBG levels in obese women with the polycystic ovary syndrome independently of any effect on serum sex steroids. (qxmd.com)
- Lee Biosolutions sells Human Serum Sex Hormone Binding Globulin (SHBG) for research and diagnostic manufacturing purposes. (leebio.com)
- Sex-hormone binding globulin (SHBG) was associated inversely with ABSI but positively with HI and was lowest for "apple" and highest for "pear" phenotype in both sexes. (nature.com)
- Inverse associations of WHR and body mass index (BMI) with total oestradiol but positive associations with free oestradiol in pre-menopausal women, as well as positive associations with total and free testosterone and inverse associations with sex hormone binding globulin (SHBG) in all women have been reported for the UK Biobank cohort 6 . (nature.com)
Proteins8
- The serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. (medlineplus.gov)
- This test is done to look at globulin proteins in the blood. (medlineplus.gov)
- Globulin in the normal range usually implies a normal balance of carrier proteins, enzymes, and antibodies that are needed for many biological processes. (studybuff.com)
- Inherited or acquired variations in the concentration and/or affinity of these proteins may produce substantial changes in serum total TH levels measured by commercially available assays. (medscape.com)
- Serum sickness classically occurs in the setting of exposure to heterologous (non-human) serum proteins causing deposition of antigen-antibody complexes in vessels or tissues, resulting in activation of the complement cascade and recruitment of immune cells, specifically neutrophils. (clinnephrologyjournal.com)
- Electrophoresis of serum proteins showed increased levels of gamma globulins. (cdc.gov)
- The proteins account for 5% of the serum globulin fraction. (dadamo.com)
- Almost three decades ago, we postulated the same hypothesis, based on histologic analysis of aged brains, demonstrating a blood brain barrier (BBB) breakdown and leakage of serum proteins in aged (but not young) human brain ( Pappolla and Andorn, 1987 ). (alzforum.org)
Immune serum globulin3
- What is immune serum globulin used for? (studybuff.com)
- Is immune serum globulin a vaccine? (studybuff.com)
- Title : Evaluation of immune serum globulin for control of infectious hepatitis Personal Author(s) : Noble, H. Bates;Peterson, Donald R. (cdc.gov)
Thyroxine5
- A change in thyroxine-binding globulin (TBG) concentration may be of hereditary, pathophysiologic, or pharmacologic origin. (blallab.com)
- Thyroxine-binding globulin (TBG) deficiency is a benign condition that is either acquired or inherited. (medscape.com)
- Thyroxine-binding globulin (TBG) is a 395-amino acid, 54kd polypeptide that is synthesized in the liver and encoded by a single gene copy. (medscape.com)
- This protein is called thyroxine-binding globulin (TBG). (medlineplus.gov)
- Estrogen, Oral Contraceptives: Estrogens tend to increase serum thyroxine -binding globulin (TBg). (pediatriconcall.com)
Estradiol4
- Sex hormone-binding globulin is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. (leebio.com)
- Twenty-eight (28) yellow tablets each containing 90 mcg of levonorgestrel (17α)-(-)13-ethyl-17-hydroxy-18, 19-dinorpregn-4-en-20-yn-3-one, a totally synthetic progestogen, and 20 mcg of ethinyl estradiol, (17α)-19-norpregna-1,3,5(10)-trien-20-yne-3,17-diol. (rxlist.com)
- Estradiol, sex hormone binding globulin, and prolactin were measured in serum collected from subjects during the same clinic visit. (cdc.gov)
- The suppressed PRL response to TRH was not explained by changes in serum estradiol or sex hormone-binding globulin. (lu.se)
Concentrations5
- The total concentrations of α 2 globulin and two of its components, haptoglobin and caeruloplasmin, have been determined in the sera from 78 patients with primary malignant diseases of lympho-reticular tissue (reticuloses). (bmj.com)
- There was possibly some correlation between the rise in haptoglobin and caeruloplasmin concentrations and the total α 2 globulin in Hodgkin's disease but this was not statistically significant. (bmj.com)
- The measurement of TBG can be used to establish the presence of TBG deficiency or excess suggested by abnormal Total serum T4 and T3 concentrations in the presence of normal free levels of these hormones. (blallab.com)
- Thyroid function tests (TFTs) in patients with TBG deficiency show normal TSH and free T4, but low total T4 and, occasionally, low total T3 serum concentrations. (medscape.com)
- Soy product intake is inversely associated with serum androgen and estrogen concentrations in Japanese men. (greenmedinfo.com)
Antibodies8
- Gamma globulins include various types of antibodies such as immunoglobulins (Ig) M, G, and A. (medlineplus.gov)
- Two subgroups of SSD(+) and SSD(-) patients that had received ATG induction treatment were then assessed for total anti-ATG, anti-Neu5Gc, and anti-Gal antibodies using ELISA assays on sera before and after transplantation. (nih.gov)
- A group of polyspecific and monospecific anti-globulins for detecting sensitization by different types of antibodies and antibodies against different components of the complement. (grifols.com)
- A sterile solution of globulins derived from pooled human blood that contains antibodies that are normally present in the blood of adults, used as a passive immunizing agent against rubella, measles, and hepatitis A and as treatment for hypogammaglobulinemia. (studybuff.com)
- a globulin or mixture of globulins occurring in blood serum and containing most of the antibodies of the blood. (studybuff.com)
- The increase in this serum globulin coincides closely with the appearance of antibodies to malaria as detected by fluorescent antibody studies. (ajtmh.org)
- Evidence is presented that 19S β 2 M macroglobulin antibodies as well as 7S gamma globulin antibodies are formed during the course of primary malarial infections in human volunteers. (ajtmh.org)
- RESULTS: Rabies virus antibodies present in serum and cerebrospinal fluid were non-neutralizing. (cdc.gov)
Immunoglobulins2
- A strong association was found between serum immunoglobulins levels and hepatic fibrosis in non-transplanted patients with chronic HCV infection. (biu.ac.il)
- The aim of this study was to determine if serum globulin and immunoglobulins levels can predict the extent of fibrosis in patients with recurrent HCV infection. (biu.ac.il)
Electrophoresis1
- It was found to be distinct immunologically from nonirradiated or heated human serum γ-globulin by quantitative precipitin tests and possessed a slow moving component as determined by paper strip electrophoresis. (aai.org)
Thyroid-stimula1
- Serum T4 and T3 levels are low, and thyroid-stimulating hormone (TSH) level is increased. (msdmanuals.com)
Hormone3
- The hospital course of a patient with milk-alkali syndrome who, during treatment, developed symptomatic hypocalcemia with a markedly elevated serum parathyroid hormone level (PTH). (medscape.com)
- A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome. (qxmd.com)
- Caloric restriction reduces serum testosterone levels and increases serum sex hormone-binding globulin in humans. (greenmedinfo.com)
Fraction1
- The total α 2 globulin fraction was significantly raised only in Hodgkin's disease. (bmj.com)
Gamma2
- Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. (medlineplus.gov)
- Immunoglobulin (also called gamma globulin or immune globulin) is a substance made from human blood plasma. (studybuff.com)
Antithymocyte1
- Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. (nih.gov)
Vaccine3
- Immunization is coded 3E0134Z Introduction of Serum, Toxoid and Vaccine into Subcutaneous Tissue, Percutaneous Approach. (fortherecordmag.com)
- Postexposure prophylaxis (PEP) with hepatitis B immune globulin (HBIG) and/or hepatitis B vaccine series should be considered for occupational exposures after evaluation of the hepatitis B surface antigen status of the source and the vaccination and vaccine-response status of the exposed person. (cdc.gov)
- For the CPT 2024 code set, the Panel further updated this process to not only include vaccine products but also immunization products (e.g., immune globulins). (ama-assn.org)
Including serum sickness1
- However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). (nih.gov)
Hyperthyroidism1
- Hyperthyroidism can cause elevated serum calcium levels due to high bone turnover. (medscape.com)
Levels9
- High globulin levels may also indicate certain types of cancer, such as multiple myeloma, Hodgkin's disease, or malignant lymphoma. (studybuff.com)
- Conversely, patients with high TBG levels may be clinically euthyroid with high serum total T4 values. (blallab.com)
- Serum calcium levels can range from a mild elevation to a severe, life-threatening elevation of higher than 18 mg/dL. (medscape.com)
- Adrenal failure also can be associated with high serum calcium levels, although the mechanism has not been fully explained. (medscape.com)
- If serum PTH is measured after treatment has started, the levels will be unpredictable and the results will be confusing. (medscape.com)
- In conclusion, serum levels of globulin and IgG can serve as a noninvasive marker of the extent of hepatic fibrosis in patients with post-transplant recurrent HCV infection, thus avoiding the need for repeated liver biopsies. (biu.ac.il)
- While continuing leuprolide treatment, the women were administered oral diazoxide (300 mg/day) for 10 days to suppress serum insulin levels. (qxmd.com)
- They have poor antibody responses to polysaccharide antigens but elevated levels of serum immunoglobulin A (IgA) and immunoglobulin E (IgE) with low levels of immunoglobulin M (IgM). (medscape.com)
- When normal women were treated with T4 (0.5 mg daily for 6 to 10 days), their mean serum free T4 level increased to about 70% of that in the hyperthyroid patients, whereas their serum free T3 levels increased to a lesser degree. (lu.se)
Reduces serum1
- Licorice reduces serum testosterone in healthy women. (greenmedinfo.com)
Hepatitis2
- Immune globulin and antiviral agents (e.g., interferon with or without ribavirin) are not recommended for PEP of hepatitis C. For HCV postexposure management, the HCV status of the source and the exposed person should be determined, and for HCP exposed to an HCV positive source, follow-up HCV testing should be performed to determine if infection develops. (cdc.gov)
- All pregnant women in the United States should be screened for hepatitis B. If infected, the baby will need to receive specific hepatitis B immune globulin and be vaccinated at birth. (healthywomen.org)
Measurement1
- The incidence of permanent hypothyroidism after radiation therapy is high, and thyroid function (through measurement of serum TSH) should be evaluated at 6- to 12-month intervals. (msdmanuals.com)
Antibody2
- Best results are obtained with diluted normal serum from the same host as the labeled antibody, as a separate incubation step before addition of the primary antibody. (jacksonimmuno.com)
- Despite data that shows fewer rejection and better graft survival using antibody induction, serious side-effects of thymoglobulin have been reported, including cardiopulmonary decompensation, respiratory distress syndrome, hematologic disorders, and serum sickness. (clinnephrologyjournal.com)
Acute3
- The serum haptoglobin was also significantly increased in Hodgkin's disease and some other reticuloses, including acute leukaemia, lymphosarcoma, and reticulum cell sarcoma. (bmj.com)
- Herein, we present a case of a patient with a known history of thymoglobulin-induced serum sickness, who presented with evidence of acute cellular and vascular rejection at their 12-month post-operative visit. (clinnephrologyjournal.com)
- To the author's knowledge, this is the first case report of successful administration of ATGAM in a patient with a documented history of thymoglobulin induced serum sickness, demonstrating a possible treatment option for acute rejection in patients with reactions to thymoglobulin. (clinnephrologyjournal.com)
Concentration1
- Serum phosphorus concentration can be elevated in milk-alkali syndrome due to a low PTH level, although this finding is less prevalent in the present era than it was when ingestion of milk and bicarbonate caused the syndrome. (medscape.com)
Level6
- The serum level of caeruloplasmin was raised in all reticuloses. (bmj.com)
- What is a good globulin level? (studybuff.com)
- An elevated serum calcium level should initiate a workup that includes the possibility of milk-alkali syndrome. (medscape.com)
- The combination of severe renal impairment and a high serum PTH level suggests secondary or tertiary hyperparathyroidism. (medscape.com)
- On linear regression analysis, for each 0.5-g/dL increase in serum globulin level, there was a 0.22-point increase in fibrosis stage. (biu.ac.il)
- When the normal women took T3 (60-120 micrograms for 6 to 8 days), their serum free T3 increased to almost the level of the hyperthyroid patients, but the TRH stimulated PRL release remained close to the control level. (lu.se)
Vitro2
Disease2
- The significance of these results is discussed, and it is concluded that the increase in α 2 globulin which occurs in Hodgkin's disease is due to an increase in several of its components and not to a single component. (bmj.com)
- METHODS: ANA and SMA reactivity of 61 AIH sera and 72 non-alcoholic fatty liver disease controls were separately assessed on tissue sections and HEp-2 cells to compare the diagnostic value at increasing titers. (bvsalud.org)
Human1
- Deliver certainty to patients with high-quality anti-human globulin sera. (grifols.com)
Kidney1
- We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [SSD(+)] and 803 without SSD [SSD(-)]) from the Données Informatisées et Validées en Transplantation data bank. (nih.gov)
Occurs1
- The normal range of globulin is around 2.0-3.9 g/dL or 20-39 g/L. Some lab-to-lab variability occurs due to differences in equipment, techniques, and chemicals used. (studybuff.com)
Symptoms1
- What are the symptoms of high globulin? (studybuff.com)
Induce1
- Despite its frequent use and efficacy, the heterologous makeup of thymoglobulin can induce the immune system resulting in serum sickness which typically presents with rash, fever, fatigue, and poly-arthralgia in the weeks following drug exposure. (clinnephrologyjournal.com)
Sodium1
- Normal serums are lipid extracted to improve clarity, dialyzed against phosphate buffered saline (PBS) containing sodium azide, and freeze dried. (jacksonimmuno.com)
Normal3
- What is normal range for globulin? (studybuff.com)
- Normal value ranges are: Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L) IgM component: 75 to 300 milligrams per deciliter (mg/dL) or 750 to 3,000 milligrams per liter (mg/L) IgG component: 650 to 1,850 mg/dL or 6.5 to 18.50 g/L. (studybuff.com)
- Normal serum diluted to 5% (v/v) in PBS is strongly recommended as a blocking reagent to reduce background from non-specific, conserved sequence and/or Fc receptor binding. (jacksonimmuno.com)
Calcium1
- The product of serum calcium and phosphorus is an important predictor of the risk of metastatic calcification. (medscape.com)
Exposure1
- Post-exposure prophylaxis with antirabies serum immune globulin was prescribed in 9% of the cases ( n = 90). (rrh.org.au)
Fluid1
- This fluid is called serum. (medlineplus.gov)
High1
- Why is serum globulin high? (studybuff.com)
Types1
- Identifying the types of globulins can help diagnose certain medical problems. (medlineplus.gov)
Receptor1
- Autoantibody against the angiotensin II type I receptor (AT1-AA) has been found in the serum of patients with diabetes mellitus (DM). (bvsalud.org)
Plasma1
- Carprofen was detected in serum and plasma samples obtained from the dog. (avma.org)